Description

Summary: Lists of constrained elements.
For each 12-mer in the human genome a measure of constraint was scored using SiPhy (see reference below), both as a rate-based score (omega), and a measure that includes biased substitution patterns (pi). Those falling in annotated Ancestral Repeats were used as a background. An empirical cutoff score was set corresponding to 10% FDR, and all 12-mers above this score were considered significant. Overlapping significant 12-mers were clustered to yield larger elements.

Detail

There are four tracks in this set:

Credits

Data provided by Or Zuk at broad.mit.edu and Manuel Garber at broadinstitute.org

References

Garber, M. et al. Identifying novel constrained elements by exploiting biased substitution patterns Bioinformatics 25, i54-62, doi:btp190 [pii] 10.1093/bioinformatics/btp190 (2009)