Cryptochrome evolution
From genomewiki
Introduction to Cryptochromes
Cryptochromes are large flavoproteins with a curiously complex evolutionary history, beginning billions of years ago as repair enzymes for dna damaged by ultraviolet light. An old gene duplication followed by specializing divergence gave rise to two paralogs repairing distinct types of dna damage (cyclobutane pyrimidine dimers and 6-4 pyrimidine-pyrimidone pairs). These photolyases initially used FAD activated by visible blue light to undo the damage done by UV.
Since FAD has relatively low adsorbance, photolyases evolved a second site for an antenna chromophore with better light harvesting capabilities that could transfer its excitation to the FAD at the active site. This elusive second molecule may be FMN, folate, or a 5-deazariboflavin called Fo (once thought restrict to methanogenic archaea). In the case of the much-studied Drosophila, both the photolyases utilize Fo, making it a new vitamin for this species since the Fo biosynthetic genes are absent.
A second round of gene duplication of the 6-4 photolyase gave rise to a cryptochrome which retained the conformational change induced by FAD binding of blue light but lost dna repair capacity, instead specializing in entraining the day/night circadian rhythm cycle. A third round of gene duplication gave rise to two cryptochromes CRY1 and CRY2.
These four genes were retained in various combinations in different clades during the subsequent course of evolution, causing endless comparative genomic confusion. For example, Drosophila did not retain CRY2 unlike other insects and placental mammals lost both photolyases though marsupials retained one. Rayfinned fish had a series of further duplications within the gene family. Over all this, the fold, exon structure and FAD binding site were largely conserved, while antenna molecules and dna repair capacity were sometimes lost, even as altogether new binding properties developed giving some family members important new regulatory capacities.
(to be continued shortly)
Standard lab mouse C57BL/6J has a mutated CRY1 cryptochrome gene
Lab mouse has an odd mutation in its 10th exon where a century of inbreeding may have inadvertently fixed a very serious 54 bp tandem stutter mutation resulting in 18 additional amino acids (the NGGLMGYAPGENVPSCSGG red and blue repeats in NM_007771 reference sequence) that would very likely disrupt the C-terminal region of the protein. The repeat is preceded by the substitution of a serine (shown in magenta in the alignment below) for a strictly invariant proline (back to chondrichthyes).
Although this region lies beyond the two main domains and has a complex evolutionary history, phylogenetic comparison to the eight available rodent and lagomorph sequences implies that this change in lab mouse will have serious functional consequences. A mutation in this critical pacemaker gene could plausibly affect lifespan, metabolic disorder and tumor progression; such a change is completely unprecedented in rodents including rat and indeed in vertebrates.
All 14 available transcripts exhibit the same anomaly -- this is not limited to one strain of mouse, not a somatic mutation, not an unfortunate heterozygous allele. The affected ESTs came from C57BL/6J, C57BL/6, C57BL/6J x DBA/2J, 129 FVB/N and embryo, eye, ventricle, thymus, mammary tumor; the affected GenBank NR entries add a keratinocyte cell line Pam. The mouse genome project used C57BL/6J, the most widely used inbred strain according to the Jackson Laboratory:
"Although C57BL/6J is refractory to many tumors, it is a permissive background for maximal expression of most mutations. C57BL/6J mice are resistant to audiogenic seizures, have a relatively low bone density, and develop age related hearing loss. They are also susceptible to diet-induced obesity, type 2 diabetes, and atherosclerosis. C57BL/6J mice are used in a wide variety of research areas including cardiovascular biology, developmental biology, diabetes and obesity, genetics, immunology, neurobiology, and sensorineural research. C57BL/6J mice are also commonly used in the production of transgenic mice. Overall, C57BL/6 mice breed well, are long-lived, and have a low susceptibility to tumors. Primitive hematopoietic stem cells from C57BL/6J mice show greatly delayed senescence relative to BALB/c and DBA/2J. This is a dominant trait. Other characteristics include: 1) a high susceptibility to diet-induced obesity, type 2 diabetes, and atherosclerosis; 2) a high incidence of microphthalmia and other associated eye abnormalities; 3) resistance to audiogenic seizures; 4) low bone density; 5) hereditary hydrocephalus (early reports indicate 1 - 4 %); 6) hairloss associated with overgrooming, 7) a preference for alcohol and morphine; 8) late-onset hearing loss; and 9) increased incidence of hydrocephalus and malocclusion."
Although this distal region is not modelled in any PDB structure as of March 2012, it has been specifically addressed in 4 of the 195 articles on mouse CRY1 or CRY2.
"purified mCRY1/2CCtail proteins form stable heterodimeric complexes with two C-terminal mBMAL1 fragments. The longer mBMAL1 fragment (BMAL490) includes Lys-537, which is rhythmically acetylated by mCLOCK in vivo. mCRY1 (but not mCRY2) has a lower affinity to BMAL490 than to the shorter mBMAL1 fragment (BMAL577) and a K537Q mutant version of BMAL490. Using peptide scan analysis we identify two mBMAL1 binding epitopes within the coiled coil RLNIERMKQIYQQLSRYR and tail regions of mCRY1/2 and document the importance of positively charged mCRY1 residues for mBMAL1 binding."
"mammalian CRY1 and CRY2 are integral components of the circadian oscillator. However, the function of their C terminus remains to be resolved. Here, we show that the C-terminal extension of mCRY1 harbors a nuclear localization signal and a putative coiled-coil domain that drive nuclear localization via two independent mechanisms and shift the equilibrium of shuttling mammalian CRY1 (mCRY1)/mammalian PER2 (mPER2) complexes towards the nucleus. Importantly, deletion of the complete C terminus prevents mCRY1 from repressing CLOCK/BMAL1-mediated transcription, whereas a plant photolyase gains this key clock function upon fusion to the last 100 amino acids of the mCRY1 core and its C terminus. Thus, the acquirement of different (species-specific) C termini during evolution not only functionally separated cryptochromes from photolyase but also caused diversity within the cryptochrome family."
"The mCRY1 and mCRY2 genes are located on chromosome 10C and 2E, respectively, and are expressed in all mouse organs examined. We raised antibodies specific against each gene product using its C-terminal sequence, which differs completely between the genes. Immunofluorescent staining of cultured mouse cells revealed that mCRY1 is localized in mitochondria whereas mCRY2 was found mainly in the nucleus. The subcellular distribution of CRY proteins was confirmed by immunoblot analysis of fractionated mouse liver cell extracts. Using green fluorescent protein fused peptides we showed that the C-terminal region of the mouse CRY2 protein contains a unique nuclear localization signal, which is absent in the CRY1 protein. The N-terminal region of CRY1 was shown to contain the mitochondrial transport signal. Recombinant as well as native CRY1 proteins from mouse and human cells showed a tight binding activity to DNA Sepharose, while CRY2 protein did not"
"genetic screening assay for mutant circadian clock proteins that is based on real-time circadian rhythm monitoring in cultured fibroblasts. By using this assay, we identified a domain in the extreme C terminus of BMAL1 that plays an essential role in the rhythmic control of E-box-mediated circadian transcription. Remarkably, the last 43 aa of BMAL1 are required for transcriptional activation, as well as for association with the circadian transcriptional repressor CRY1"
507 517 527 537 547 557 567 577 587 597
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CRY1_musMus GLLASVPSNSNGNGGLMGYAPGENVPSCSSSGNGGLMGYAPGENVPSCSGG NCSQGSGILHYAHGDSQQTHSLKQ GRSSAGTGLSSGKRPSQEEDAQSVGPKVQRQSSN*
CRY1_ratNor GLLASVPSNPNGNGGLMGYAPGENVPSGGSGG------------------G NCSQGSGILHYAHGDSQQTNPLKQ GRSSMGTGLSSGKRPSQEEDAQSVGPKVQRQSSN*
CRY1_criGri GLLASVPSNPNGNGGLMGYTTGENLPSCSGGG------------------- SCSQGSGILHYAHGDSQQAHLLKQ GRSSMGTSLSSGKRPSQEEETRSVDPKVQRQSSN*
CRY1_spaJud GLLASVPSNPNGNGGLMGYTPGENIPNCSSSG------------------- SCSQGSGILHYAHGDSQQAHLLKQ GSSSMGHGLSNGKRPSQEEDTQSIGPKVQRQSTN*
CRY1_dipOrd GLLASVPSNPNGNGGLMGYAAGDNLPGSSSSG------------------- SCSQGSGILHYAHGDSQQMHLLKQ GRSSMGTGLSSGKRPSQEEDSQSIGPKVQRQSTN*
CRY1_hetGla GLLASVPSNPNGNGGLMGYAPGESIPGSSGSG------------------- SCAHGSGILPCAHTDGQQAHLLKP GRNCVGPVLSSGKRPSQEEDAQSIGPKLQRQSTD*
CRY1_cavPor GLLASVPSNPNGNGGLLGYAPGESTPGSGGG-------------------- SCVPGSSSAGVSHCAQGEAPQAPP GRDPAGPGLGGGKRPSQEEDAQSTGHKIQRQSPD*
CRY1_speTri GLLASVPSNPNGNGGLMAYAPGENIPGCSSSG------------------- SCTQGSSILHNAHGDSQQTHLLKQ GRSSMGTGLSSGKRPSQEEDTQSIGPKVQRQSTN*
CRY1_oryCun GLLASVPSNPNGNGGLMGYSPGENIPGCSSSG------------------- SCSQGSGILHYAQGDTQQTQLLKQ GRSSMGTGLSSGKRPSQEEDTQSIGPKVQRQSTN*
CRY1_musMus GLLASVPSNSNGNGGLMGYAPGENVPSCSSSGNGGLMGYAPGENVPSCSGG NCSQGSGILHYAHGDSQQTHSLKQ GRSSAGTGLSSGKRPSQEEDAQSVGPKVQRQSSN*
CRY1_ratNor .........P.................GG.G.------------------. ...................NP... ....M.............................
CRY1_criGri .........P.........TT...L....GG.------------------- S.................A.L... ....M..S...........ETR..D.........
CRY1_spaJud .........P.........T....I.N.....------------------- S.................A.L... .S..M.H...N.........T..I........T.
CRY1_dipOrd .........P..........A.D.L.GS....------------------- S.................M.L.... ...M...............S..I........T.
CRY1_hetGla .........P.............SI.GS.G..------------------- S.AH.....PC..T.G..A.L..P. .NCV.PV...............I...L....TD
CRY1_cavPor .........P......L......ST.GSGGG-------------------- S.VP..SSAGVS.CAQGEAPQAPP. .DP..P..GG............T.H.I....PD
CRY1_speTri .........P.......A......I.G.....------------------- S.T...S...N.........L.... ...M...............T..I........T.
CRY1_oryCun .........P.........S....I.G.....------------------- S...........Q..T...QL.... ...M...............T..I........T.
COILs coiled coil prediction for mouse CRY1 480-493 RLNIERMKQIYQQLSRYR
478 R e 0.644
479 L f 0.644
480 N g 0.806
481 I a 0.806
482 E b 0.806
483 R c 0.806
484 M d 0.806
485 K e 0.806
486 Q f 0.806
487 I g 0.806
488 Y a 0.806
489 Q b 0.806
490 Q c 0.806
491 L d 0.806
492 S e 0.806
493 R f 0.806
494 Y d 0.375
495 R e 0.375
>CRY1_musMus Mus musculus (mouse) NM_007771 all transcripts support longer exon 10 lost splice donor
1 RYLPVLRGFPAKYIYDPWNAPEGIQKVAKCLIGVNYPKPMVNHAEASRLNIERMKQIYQQLSRYRYRGL 1
2 GLLASVPSSNGNGGLMGYAPGENVPSCSSSGNGGLMGYAPGENVPSCSGG 1
2 NCSQGSGILHYAHGDSQQTHSLKQ 1
2 GRSSAGTGLSSGKRPSQEEDAQSVGPKVQRQSSN* 0
>CRY1_ratNor Rattus norvegicus (rat) NM_198750
1 RYLPVLRGFPAKYIYDPWNAPEGIQKVAKCLIGVNYPKPMVNHAEASRLNIERMKQIYQQLSRYRGL 1
2 GLLASVPSNPNGNGGLMGYAPGENVPSGGSGGG 1
2 NCSQGSGILHYAHGDSQQTNPLKQ 1
2 GRSSMGTGLSSGKRPSQEEDAQSVGPKVQRQSSN* 0
>CRY1_criGri Cricetulus griseus (hamster) XM_003505292
1 RYLPVLRGFPAKYIYDPWNAPEGIQKVAKCLIGVNYPKPMVNHAEASRLNIERMKQIYQQLSRYRGL 1
2 GLLASVPSNPNGNGGLMGYTTGENLPSCSGGG 1
2 SCSQGSGILHYAHGDSQQAHLLKQ 1
2 GRSSMGTSLSSGKRPSQEEETRSVDPKVQRQSSN* 0
>CRY1_spaJud Spalax judaei (blind_mole_rat) AJ606298
1 RYLPVLRGFPAKYIYDPWNAPEGIQKVAKCLIGVNYPKPMVNHAEASRLNIERMKQIYQQLSRYRGL 1
2 GLLASVPSNPNGNGGLMGYTPGENIPNCSSSG 1
2 SCSQGSGILHYAHGDSQQAHLLKQ 1
2 GSSSMGHGLSNGKRPSQEEDTQSIGPKVQRQSTN* 0
>CRY1_dipOrd Dipodomys ordii (kangaroo_rat) ABRO01202522 ABRO01202521
1 RYLPVLRGFPAKYIYDPWNAPEGIQKVAKCLIGVNYPKPMVNHAEASRLNIERMKQIYQQLSRYRGL 1
2 GLLASVPSNPNGNGGLMGYAAGDNLPGSSSSG 1
2 SCSQGSGILHYAHGDSQQMHLLKQ 1
2 GRSSMGTGLSSGKRPSQEEDSQSIGPKVQRQSTN* 0
>CRY1_hetGla Heterocephalus glaber (blind_mole-rat)
1 RYLPVLRGFPAKYIYDPWNAPEGIQKVAKCLIGVNYPKPMVNHAEASRLNIERMKQIYQQLSRYRGL 1
2 GLLASVPSNPNGNGGLMGYAPGESIPGSSGSG 1
2 SCAHGSGILPCAHTDGQQAHLLKP 1
2 GRNCVGPVLSSGKRPSQEEDAQSIGPKLQRQSTD* 0
>CRY1_cavPor Cavia porcellus (guinea_pig) last two exons diverged
1 RYLPVLRGFPAKYIYDPWNAPEGIQKVAKCLIGVNYPKPMVHHAEASRLNIERMKQIYQQLSRYRGL 1
2 GLLASVPSNPNGNGGLLGYAPGESTPGSGGG 1
2 SCVPGSSSAGVSHCAQGEAPQAPP 1
2 GRDPAGPGLGGGKRPSQEEDAQSTGHKIQRQSPD* 0
>CRY1_speTri Spermophilus tridecemlineatus (squirrel) Ictidomys
1 RYLPVLRGFPAKYIYDPWNAPEGIQKVAKCLIGVNYPKPMVNHEASLNIERMKQIYQQLSRYRGL 1
2 GLLASVPSNPNGNGGLMAyAPGENIPGCSSSG 1
2 SCTQGSSILHNAHGDSQQTHLLKQ 1
2 GRSSMGTGLSSGKRPSQEEDTQSIGPKVQRQSTN* 0
>CRY1_oryCun Oryctolagus cuniculus (rabbit)
1 RYLPVLRGFPAKYIYDPWNAPEGIQKVAKCLIGINYPKPMVNHAEASRLNIERMKQIYQQLSRYRGL 1
2 GLLASVPSNPNGNGGLMGYSPGENIPGCSSSG 1
2 SCSQGSGILHYAQGDTQQTQLLKQ 1
2 GRSSMGTGLSSGKRPSQEEDTQSIGPKVQRQSTN* 0
>CRY1_ochPri Ochotona princeps (pika)
1 1
2 1
2 GCPQGSGILHCGHGDSQQTHLLKQ 1
2 GRGSPDTGISSGKRPSQEEDTQSIGPKVQRQSTN* 0
Vertebrate CRY1 reference sequences
>CRY1_homSap Homo sapiens (human) 0 MGVNAVHWFRKGLRLHDNPALKECIQGADTIRCVYILDPWFAGSSNVGINRWR 2 1 FLLQCLEDLDANLRKLNSRLFVIRGQPADVFPRLFK 0 0 EWNITKLSIEYDSEPFGKERDAAIKKLATEAGVEVIVRISHTLYDLDK 2 1 IIELNGGQPPLTYKRFQTLISKMEPLEIPVETITSEVIEKCTTPLSDDHDEKYGVPSLEEL 1 2 GFDTDGLSSAVWPGGETEALTRLERHLERK 0 0 AWVANFERPRMNANSLLASPTGLSPYLRFGCLSCRLFYFKLTDLYKK 0 0 VKKNSSPPLSLYGQLLWREFFYTAATNNPRFDKMEGNPICVQIPWDKNPEALAKWAEGRTGFPWIDAIMTQLRQEGWIHHLARHAVACFLTRGDLWISWEEGMK 0 0 VFEELLLDADWSINAGSWMWLSCSSFFQQFFHCYCPVGFGRRTDPNGDYIR 2 1 RYLPVLRGFPAKYIYDPWNAPEGIQKVAKCLIGVNYPKPMVNHAEASRLNIERMKQIYQQLSRYRGL 1 2 GLLASVPSNPNGNGGFMGYSAENIPGCSSSG 1 2 SCSQGSGILHYAHGDSQQTHLLKQ 1 2 GRSSMGTGLSGGKRPSQEEDTQSIGPKVQRQSTN* 0 >CRY1_panTro Pan troglodytes (chimpanzee) XM_509339 0 MGVNAVHWFRKGLRLHDNPALKECIQGADTIRCVYILDPWFAGSSNVGINRWR 2 1 FLLQCLEDLDANLRKLNSRLFVIRGQPADVFPRLFK 0 0 EWNITKLSIEYDSEPFGKERDAAIKKLATEAGVEVIVRISHTLYDLDK 2 1 IIELNGGQPPLTYKRFQTLISKMEPLEIPVETITSEVIEKCTTPLSDDHDEKYGVPSLEEL 1 2 GFDTDGLSSAVWPGGETEALTRLERHLERK 0 0 AWVANFERPRMNANSLLASPTGLSPYLRFGCLSCRLFYFKLTDLYKK 0 0 VKKNSSPPLSLYGQLLWREFFYTAATNNPRFDKMEGNPICVQIPWDKNPEALAKWAEGRTGFPWIDAIMTQLRQEGWIHHLARHAVACFLTRGDLWISWEEGMK 0 0 VFEELLLDADWSINAGSWMWLSCSSFFQQFFHCYCPVGFGRRTDPNGDYIR 2 1 RYLPVLRGFPAKYIYDPWNAPEGIQKVAKCLIGVNYPKPMVNHAEASRLNIERMKQIYQQLSRYRGL 1 2 GLLASVPSNPNGNGGFMGYSAENIPGCSSSG 1 2 SCSQGSGILHYAHGDSQQTHLLKQ 1 2 GRSSVGTGLSGGKRPSQEEDTQSIGPKVQRQSTN* 0 >CRY1_ponAbe Pongo abelii (orangutan) XM_002823690 0 MGVNAVHWFRKGLRLHDNPALKECIQGADTIRCVYILDPWFAGSSNVGINRWR 2 1 FLLQCLEDLDASLRKLNSRLFVIRGQPADVFPRLFK 0 0 EWNITKLSIEYDSEPFGKERDAAIKKLATEAGVEVIVRISHTLYDLDK 2 1 IIELNGGQPPLTYKRFQTLISKMEPLEIPVETITSEVIEKCTTPLSDDHDEKYGVPSLEEL 1 2 GFDTDGLSSAVWPGGETEALTRLERHLERK 0 0 AWVANFERPRMNANSLLASPTGLSPYLRFGCLSCRLFYFKLTDLYKK 0 0 VKKNSSPPLSLYGQLLWREFFYTAATNNPRFDKMEGNPICVQIPWDKNPEALAKWAEGRTGFPWIDAIMTQLRQEGWIHHLARHAVACFLTRGDLWISWEEGMK 0 0 VFEELLLDADWSINAGSWMWLSCSSFFQQFFHCYCPVGFGRRTDPNGDYIR 2 1 RYLPVLRGFPAKYIYDPWNAPEGIQKVAKCLIGVNYPKPMVNHAEASRLNIERMKQIYQQLSRYRGL 1 2 GLLASVPSNPNGNGGFMGYSAENVPGCSSSG 1 2 SCSQGSGILHYAHGDSQQTHLLKQ 1 2 GRSSMGTGLSGGKRASQEEDTQSIGPKVQRQSTN* 0 >CRY1_nomLeu Nomascus leucogenys (gibbon) XM_003269977 0 MGVNAVHWFRKGLRLHDNPALKECIQGADTIRCVYILDPWFAGSSNVGINRWR 2 1 FLLQCLEDLDANLRKLNSRLFVIRGQPADVFPRLFK 0 0 EWNITKLSIEYDSEPFGKERDAAIKKLATEAGVEVIVRISHTLYDLDK 2 1 IIELNGGQPPLTYKRFQTLISKMEPLEIPVETITSEVIEKCTTPLSDDHDEKYGVPSLEEL 1 2 GFDTDGLSSAVWPGGETEALTRLERHLERK 0 0 AWVANFERPRMNANSLLASPTGLSPYLRFGCLSCRLFYFKLTDLYKK 0 0 VKKNSSPPLSLYGQLLWREFFYTAATNNPRFDKMEGNPICVQIPWDKNPEALAKWAEGRTGFPWIDAIMTQLRQEGWIHHLARHAVACFLTRGDLWISWEEGMK 0 0 VFEELLLDADWSINAGSWMWLSCSSFFQQFFHCYCPVGFGRRTDPNGDYIR 2 1 RYLPVLRGFPAKYIYDPWNAPEGIQKVAKCLIGVNYPKPMVNHAEASRLNIERMKQIYQQLSRYRGL 1 2 GLLASVPSNPNGNGGFMGYSAENIPGCSSSG 1 2 SCSQGSGILHYAHGDSQQTHLLKQ 1 2 GRSSMGTGLSGGKRPSQEEDTQSIGPKVQRQSTN* 0 >CRY1_macMul Macaca mulatta (rhesus) NM_001194159 0 MGVNAVHWFRKGLRLHDNPALKECIQGADTIRCVYILDPWFAGSSNVGINRWR 2 1 FLLQCLEDLDANLRKLNSRLFVIRGQPADVFPRLFK 0 0 EWNITKLSIEYDSEPFGKERDAAIKKLATEAGVEVIVRISHTLYDLDK 2 1 IIELNGGQPPLTYKRFQTLISKMEPLEIPVETITSEVIEKCTTPLSDDHDEKYGVPSLEEL 1 2 GFDTDGLSSAVWPGGETEALTRLERHLERK 0 0 AWVANFERPRMNANSLLASPTGLSPYLRFGCLSCRLFYFKLTDLYKK 0 0 VKKNSSPPLSLYGQLLWREFFYTAATNNPRFDKMEGNPICVQIPWDKNPEALAKWAEGRTGFPWIDAIMTQLRQEGWIHHLARHAVACFLTRGDLWISWEEGMK 0 0 VFEELLLDADWSINAGSWMWLSCSSFFQQFFHCYCPVGFGRRTDPNGDYIR 2 1 RYLPVLRGFPAKYIYDPWNAPEGIQKVAKCLIGINYPKPMVNHAEASRLNIERMKQIYQQLSRYRGL 1 2 GLLASVPSNPNGNGGFMGYSTENIPGCSSSGS 1 2 CSQGSGILHYTHGDSQQTHLLKQ 1 2 GRSSMGTGLSGGKRPSQEEDTQSIGPKVQRQSTN* 0 >CRY1_calJac Callithrix jacchus (marmoset) XM_002752946 0 MGVNAVHWFRKGLRLHDNPALKECIQGADTIRCVYILDPWFAGSSNVGINRWR 2 1 FLLQCLEDLDANLRKLNSRLFVIRGQPADVFPRLFK 0 0 EWNITKLSIEYDSEPFGKERDAAIKKLATEAGVEVIVRISHTLYDLDK 2 1 IIELNGGQPPLTYKRFQTLISKMEPLEIPVETITSEVIEKCTTPLSDDHDEKYGVPSLEEL 1 2 GFDTDGLSSAVWPGGETEALTRLERHLERK 0 0 AWVANFERPRMNANSLLASPTGLSPYLRFGCLSCRLFYFKLTDLYKK 0 0 VKKNSSPPLSLYGQLLWREFFYTAATNNPRFDKMEGNPICVQIPWDKNPEALAKWAEGRTGFPWIDAIMTQLRQEGWIHHLARHAVACFLTRGDLWISWEEGMK 0 0 VFEELLLDADWSINAGSWMWLSCSSFFQQFFHCYCPVGFGRRTDPNGDYIR 2 1 RYLPVLRGFPAKYIYDPWNAPEGIQKVAKCLIGVNYPKPMVNHAEASRLNIERMKQIYQQLSRYRGL 1 2 GLLASVPSNPNGNGGFMGYSAENIPGCTSSG 1 2 SCSQGSGILHCAHGDSQQTHLLKQ 1 2 GRSSMSTGISGGKRPSQEEDTQSIGPKVQRQSTN* 0 >CRY1_saiBol Saimiri boliviensis (squirrel_monkey) nearly identical to marmoset 0 MGVNAVHWFRKGLRLHDNPALKECIQGADTIRCVYILDPWFAGSSNVGINRWR 2 1 FLLQCLEDLDANLRKLNSRLFVIRGQPADVFPRLFK 0 0 EWNITKLSIEYDSEPFGKERDAAIKKLATEAGVEVIVRISHTLYDLDK 2 1 IIELNGGQPPLTYKRFQTLISKMEPLEIPVETITSEVIEKCTTPLSDDHDEKYGVPSLEEL 1 2 GFDTDGLSSAVWPGGETEALTRLERHLERK 0 0 AWVANFERPRMNANSLLASPTGLSPYLRFGCLSCRLFYFKLTDLYKK 0 0 VKKNSSPPLSLYGQLLWREFFYTAATNNPRFDKMEGNPICVQIPWDKNPEALAKWAEGRTGFPWIDAIMTQLRQEGWIHHLARHAVACFLTRGDLWISWEEGMK 0 0 VFEELLLDADWSINAGSWMWLSCSSFFQQFFHCYCPVGFGRRTDPNGDYIR 2 1 RYLPVLRGFPAKYIYDPWNAPEGIQKVAKCLIGVNYPKPMVNHAEASRLNIERMKQIYQQLSRYRGL 1 2 GLLASVPSNPNGNGGFMGYSAENIPGCTSSG 1 2 SCSQGSGILHCAHGDSQQTHLLKQ 1 2 GRSSMSTGLGGGKRPSQEEDTQSIGPKVQRQSTN* 0 >CRY1_tarSyr Tarsius syrichta (tarsier) ABRT010205577 unsure if exon 2 is CRY1 or CRY2 0 2 1 FLLQSLEDLDTSLRKLNSRLFVVRGQPADVFPRLFK 0 0 EWNIAKLSIEYDSEPFGKERDAAIKKLATEAGVEVIVRISHTLYDLDK 0 0 IIELNGGQPPLTYKRFQTLISKMEPLEIPVETITSEVIEKCTTPLSDDHDEKYGVPSLEEL 1 2 GFDTDGLSSAVWPGGETEALTRLERHLERK 0 0 AWVANFERPRMNANSLLASPTGLSPYLRFGCLSCRLFYFKLTDLYKK 0 0 VKKNSSPPLSLYGQLLWREFFYTAATNNPRFDKMEGNPICVQIPWDKNPEALAKWAEGRTGFPWIDAIMTQLRQEGWIHHLARHAVACFLTRGDLWISWEEGMK 0 0 VFEELLLDADWSINAGSWMWLSCSSFFQQFFHCYCPVGFGRRTDPNGDYIR 2 1 RYLPVLRGFPAKYIYDPWNAPEGIQKVAKCLIGVNYPKPMVNHAEASRLNIERMKQIYQQLSRYRGL 1 2 GLLASVPSNPNGNGGFMGYSPAENTPGCSSSG 1 2 SCSQGSGILHYAHGDSQQTHLLKQ 1 2 GRSSVGTGLSGGKRPSQEEDPQSIGPKVQRQSTN* 0 >CRY1_micMur Microcebus murinus (mouse_lemur) 0 MGVNAVHWFRKGLRLHDNPALKECIQGADTIRCVYILDPWFAGSSNVGINRWR 2 1 FLLQCLEDLDANLRKLNSRLFVIRGQPADVFPRLFK 0 0 IIELNGGQPPLTYKRFQTLISK SEVIEKCTTPLSDD 1 2 GFDTDGLSSAVWPGGETEALTRLERHLERK 0 0 AWVANFERPRMNANSLLASPTGLSPYLRFGCLSCRLFYFKLTDLYKK 0 0 VKSSPPLSLYGRYLPVLRGFPAKYIYDPWNAPEGIQKVAKCLIGVNYPKPMVNHAEASRLNIERMKQIYQQLSRYRGL 1 1 RYLPVLRGFPAKYIYDPWNAPEGIQKVAKCLIGVNYPKPMVNHAEASRLNIERMKQIYQQLSRYRGL 1 2 GLLASVPSNPNGNGGFMEYSPAENIPGCSSSG 1 2 NCSQGSGILHYAHGDSQQTHLLKQ 1 2 GRSSMGTGFSGGKRPSQEEDTQSIGSKVQRQSTN* 0 >CRY1_otoGar Otolemur garnettii (bushbaby) AAQR03016495 0 MGVNAVHWFRKGLRLHDNPALKECIQGADTIRCVYILDPWFAGSSNVGINRWR 2 1 FLLQCLEDLDANLRKLNSRLFVIRGQPADVFPRLFK 0 0 EWNITRLSIEYDSEPFGKERDAAIKKLATEAGVEVIVRISHTLYDLDK 0 0 IIELNGGQPPLTYKRFQTLISKMEPLEIPVETITSEIIEKCTTPLFDDHDEKYGVPSLEEL 1 2 AWVANFERPRMNANSLLASPTGLSPYLRFGCLSCRLFYFKLTDLYKK 0 0 VKKNSSPPLSLYGQLLWREFFYTAATNNPRFDKMEGNPICVQIPWDKNPEALAKWAEGRTGFPWIDAIMTQLRQEGWIHHLARHAVACFLTRGDLWISWEEGMK 0 0 VFEELLLDADWSINAGSWMWLSCSSFFQQFFHCYCPASFGRRTDPNGDYIR 2 1 RYLPVLRGFPAKYIYDPWNAPEGIQKVAKCLIGINYPKPMVNHAEASRLNIERMKQIYQQLSRYRGL 1 2 GLLASVPSNPNGNGSFMEYSPPENIPGCSSSG 1 2 NCSQGSGILHYAPGDGQQPHLLKQ 1 2 GRSSMGTGLSGGKRPSQEEDMQSVGPKVQRQSTN* 0 >CRY1_tupBel Tupaia belangeri (treeshrew) 0 2 1 FLLQCLEDLDANLRKLNSRLFVIRGQPADVFPRLFK 0 0 EWNITKLSIEYDSEPFGKERDAAIKKLATEAGVEVIVRISHTLYDLDK 0 0 IIELNGGQPPLTYKRFQTLISKMEPLEIPVETITSEVIEKCTTPLSDDHDEKFGVPSLEEL 1 2 GFDTDGLSSAVWPGGETEALTRLERHLERK 0 0 AWVANFERPRVNSNSLLASPTGL 0 VFEELLLDADWSINAGSWMWLSCSSFFQQFFHCYCPVGFGRRTDPNGDYIR 2 1 RYLSSSGSCSQGSGILHYAHGDSQQTHLLKQGRSSMGP 1 2 1 2 GCSQGSGILHYAHGDSQQTHLLKQ 1 2 GLSSGKRPSQEEDTQSIGPKVQRQSTN* 0 >CRY1_musMus Mus musculus (mouse) NM_007771 all transcripts support longer exon 10 lost splice donor 0 MGVNAVHWFRKGLRLHDNPALKECIQGADTIRCVYILDPWFAGSSNVGINRWR 2 1 FLLQCLEDLDANLRKLNSRLFVIRGQPADVFPRLFK 0 0 EWNITKLSIEYDSEPFGKERDAAIKKLATEAGVEVIVRISHTLYDLDK 2 1 IIELNGGQPPLTYKRFQTLVSKMEPLEMPADTITSDVIGKCMTPLSDDHDEKYGVPSLEEL 1 2 GFDTDGLSSAVWPGGETEALTRLERHLER 0 0 KAWVANFERPRMNANSLLASPTGLSPYLRFGCLSCRLFYFKLTDLYKK 0 0 VKKNSSPPLSLYGQLLWREFFYTAATNNPRFDKMEGNPICVQIPWDKNPEALAKWAEGRTGFPWIDAIMTQLRQEGWIHHLARHAVACFLTRGDLWISWEEGMK 0 0 VFEELLLDADWSINAGSWMWLSCSSFFQQFFHCYCPVGFGRRTDPNGDYIR 2 1 RYLPVLRGFPAKYIYDPWNAPEGIQKVAKCLIGVNYPKPMVNHAEASRLNIERMKQIYQQLSRYRGL 1 2 GLLASVPSNSNGNGGLMGYAPGENVPSCSSSGNGGLMGYAPGENVPSCSGG 1 2 NCSQGSGILHYAHGDSQQTHSLKQ 1 2 GRSSAGTGLSSGKRPSQEEDAQSVGPKVQRQSSN* 0 >CRY1_ratNor Rattus norvegicus (rat) NM_198750 0 MGVNAVHWFRKGLRLHDNPALKECIQGADTIRCVYILDPWFAGSSNVGINRWR 2 1 FLLQCLEDLDANLRKLNSRLFVIRGQPADVFPRLFK 0 0 EWNITKLSIEYDSEPFGKERDAAIKKLATEAGVEVIVRISHTLYDLDK 2 1 IIELNGGQPPLTYKRFQTLVSKMEPLEMPADTITSDVIGKCTTPLSDDHDEKYGVPSLEEL 1 2 GFDTDGLSSAVWPGGETEALTRLERHLERK 0 0 AWVANFERPRMNANSLLASPTGLSPYLRFGCLSCRLFYFKLTDLYKK 0 0 VKKNSSPPLSLYGQLLWREFFYTAATNNPRFDKMEGNPICVQIPWDKNPEALAKWAEGRTGFPWIDAIMTQLRQEGWIHHLARHAVACFLTRGDLWISWEEGMK 0 0 VFEELLLDADWSINAGSWMWLSCSSFFQQFFHCYCPVGFGRRTDPNGDYIR 2 1 RYLPVLRGFPAKYIYDPWNAPEGIQKVAKCLIGVNYPKPMVNHAEASRLNIERMKQIYQQLSRYRGL 1 2 GLLASVPSNPNGNGGLMGYAPGENVPSGGSGGG 1 2 NCSQGSGILHYAHGDSQQTNPLKQ 1 2 GRSSMGTGLSSGKRPSQEEDAQSVGPKVQRQSSN* 0 >CRY1_criGri Cricetulus griseus (hamster) XM_003505292 0 MGVNAVHWFRKglrlhDNPALKECIQGADTIRCVYILDPWFAGSSNVGINRWR 2 1 FLLQCLEDLDSNLRKLNSRLFVIRGQPADVFPRLFK 0 0 EWNITKLSIEYDSEPFGKERDAAIKKLATEAGVEVIVRISHTLYDLDK 2 1 IIELNGGQPPLTYKRFQTLVSKMEPLEMPAETITSDVIGKCMTPLSDDHDEKYGVPSLEEL 1 2 GFDTDGLSSAVWPGGETEALTRLERHLER 0 0 KAWVANFERPRMNANSLLASPTGLSPYLRFGCLSCRLFYFKLTDLYKK 0 0 VKKNSSPPLSLYGQLLWREFFYTAATNNPRFDKMEGNPICVQIPWDKNPEALAKWAEGRTGFPWIDAIMTQLRQEGWIHHLARHAVACFLTRGDLWISWEEGMK 0 0 VFEELLLDADWSINAGSWMWLSCSSFFQQFFHCYCPVGFGRRTDPNGDYIR 2 1 RYLPVLRGFPAKYIYDPWNAPEGIQKVAKCLIGVNYPKPMVNHAEASRLNIERMKQIYQQLSRYRGL 1 2 GLLASVPSNPNGNGGLMGYTTGENLPSCSGGG 1 2 SCSQGSGILHYAHGDSQQAHLLKQ 1 2 GRSSMGTSLSSGKRPSQEEETRSVDPKVQRQSSN* 0 >CRY1_spaJud Spalax judaei (blind_mole_rat) AJ606298 0 MGVNAVHWFRKGLRLHDNPALKECIQGADTIRCVYILDPWFAGSSNVGINRW 2 1 RFLLQCLEDLDANLRKLNSRLLVIRGQPADVFPRLFKEWNITKLSIEYDSEPFGKERDAAIKKLATEAGVEVIVRISHTLYDLDK 2 1 IIELNGGQPPLTYKRFQTLISKMEPLEIPVETITSEVIEKCTTPLSDDHDEKYGVPSLEEL 1 2 GFDTDGLSSAVWPGGETEALTRLERHLERR 0 0 AWVANFERPRMNANSLLASPTGLSPYLRFGCLSCRLFYFKLTDLYKK 0 0 VKKNSSPPLSLYGQLLWREFFYTAATNNPRFDKMEGNPICVQIPWDKNPEALAKWAEGRTGFPWIDAIMTQLRQEGWIHHLARHAVACFLTGSDLWISWEEGMK 0 0 VFEELLLDADWSINAGSWMWLSCSSFFQQFFHCYCPVGFGRRTDPNGDYIR 2 1 RYLPVLRGFPAKYIYDPWNAPEGIQKVAKCLIGVNYPKPMVNHAEASRLNIERMKQIYQQLSRYRGL 1 2 GLLASVPSNPNGNGGLMGYTPGENIPNCSSSG 1 2 SCSQGSGILHYAHGDSQQAHLLKQ 1 2 GSSSMGHGLSNGKRPSQEEDTQSIGPKVQRQSTN* 0 >CRY1_dipOrd Dipodomys ordii (kangaroo_rat) ABRO01202522 ABRO01202521 0 MGVNAVHWFRKGLRLHDNPALKECIQGADTIRCVYILDPWFAGSSNVGINRW 2 1 RFLLQCLEDLDANLRKLNSRLFVIRGQPADVFPRLFK 0 0 EWNITKLSIEYDSEPFGKERDAAIKKLATEAGVEVIVRISHTLYDLDK 2 1 IIELNGGQPPLTYKRFQTLISKMEPLEIPVETITSEVIEKCTTPLSDDHDEKYGVPSLEEL 1 2 GFDTDGLSSAVWPGGETEALTRLERHLERK 0 0 AWVANFERPRMNANSLLASPTGLSPYLRFGCLSCRLFYFKLTDLYKK 0 0 VKKNSSPPLSLYGQLLWREFFYTAATNNPRFDKMEGNPICVQIPWDKNPEALAKWAEGRTGFPWIDAIMTQLRQEGWIHHLARHAVACFLTRGDLWISWEEGMK 0 0 VFEELLLDADWSINAGSWMWLSCSSFFQQFFHCYCSVGFGRRTDPNGDYIR 2 1 RYLPVLRGFPAKYIYDPWNAPEGIQKVAKCLIGVNYPKPMVNHAEASRLNIERMKQIYQQLSRYRGL 1 2 GLLASVPSNPNGNGGLMGYAAGDNLPGSSSSG 1 2 SCSQGSGILHYAHGDSQQMHLLKQ 1 2 GRSSMGTGLSSGKRPSQEEDSQSIGPKVQRQSTN* 0 >CRY1_hetGla Heterocephalus glaber (mole-rat) stop codon in place of conserved W8, last two exons very diverged 0 MAMNAVH*FRKGLRLHDNPALKECTRGADTIRCVYILDPWFAGSSNVGINRWR 2 1 FLLQCLEDLDANLRKLNSRLFVIRGQPADVFPRLFK 0 0 EWNITKLSIEYDSEPFGKERDAAIKKLATEAGVEVIVRISHTLYDLDK 2 1 IIELNGGQPPLTYKRFQTLISKMEPLEIPVETITSEVIEKCVTPLSDDHDEKYGVPSLEEL 1 2 GFDTDGLPSAVWPGGETEALTRLERHLERK 0 0 AWVANFERPRMNANSLLASPTGLSPYLRFGCLSCRLFYFKLTDLYKK 0 0 VKKNSSPPLSLYGQLLWREFFYTAATNNPRFDKMEGNPICVQIPWDKNPEALAKWAEGRTGFPWIDAIMTQLRQEGWIHHLARHAVACFLTRGDLWVSWEEGMK 0 0 VFEELLLDADWSINAGSWMWLSCSSFFQQFFHCYCPVGFGRRTDPNGDYIR 2 1 RYLPVLRGFPAKYIYDPWNAPEGIQKVAKCLIGVNYPKPMVNHAEASRLNIERMKQIYQQLSRYRGL 1 2 GLLASVPSNPNGNGGLMGYAPGESIPGSSGSG 1 2 SCAHGSGILPCAHTDGQQAHLLKP 1 2 GRNCVGPVLSSGKRPSQEEDAQSIGPKLQRQSTD* 0 >CRY1_cavPor Cavia porcellus (guinea pig) last two exons diverged 69 bp separation 0 MGVNAVHWFRKGLRLHDNPALKECIRGADTIRCVYILDPWFAGSSNVGINRWR 2 1 FLLQCLEDLDANLRKLNSRLFVIRGQPADVFPRLFK 0 0 EWNITKLSIEYDSEPFGKERDAAIKKLASEAGVEVIVRISHTLYDLDK 2 1 IIELNGGQPPLTYKRFQTLISKMEPLEIPVETITSEVVEKCVTPLSDDHDEKYGVPSLEEL 1 2 GFDTDGLPSAVWPGGETEALTRLERHLERK 0 0 AWVANFERPRMNANSLLASPTGLSPYLRFGCLSCRLFYFKLTDLYKK 0 0 VKKNSSPPLSLYGQLLWREFFYTAATNNPRFDKMEGNPICVQIPWDRNPEALAKWAEGRTGFPWIDAIMTQLRQEGWIHHLARHAVACFLTRGDLWVSWEEGMK 0 0 VFEELLLDADWSINAGSWMWLSCSSFFQQFFHCYCPVGFGRRTDPNGDYIR 2 1 RYLPVLRGFPAKYIYDPWNAPEGIQKVAKCLIGVNYPKPMVHHAEASRLNIERMKQIYQQLSRYRGL 1 2 GLLASVPSNPNGNGGLLGYAPGESTPGSGGG 1 2 SCVPGSSSAGVSHCAQGEAPQAPP 1 2 GRDPAGPGLGGGKRPSQEEDAQSTGHKIQRQSPD* 0 >CRY1_speTri Spermophilus tridecemlineatus (squirrel) Ictidomys 0 2 1 0 RDAAIKKLATEAGVEVIVRISHTLYDLDK 2 1 IIELNGGQPPLTYKRFQTLISKMEPLEIPVETITSEVIEKCTTPLSDDHDEKYGVPSLEEL 1 2 GFDTDGLSSAVWPGGETEALTRLERHLERK 0 0 AWVANFERPRMNANSLLASPTGLSPYLRFGCLSCRLFYFKLTDLYKK 0 0 VKKNSSPPLSLYGQLLWREFFYTAATNNPRFDKMEGNPICVQIPWDKNPEALAKWAEGRTGFPWIDAIMTQLRQEGWIHHLARHAVACFLTRGDLWISWEEGMK 0 0 VFEELLLDADWSINAGSWMWLSCSSFFQQFFHCYCPVGFGRRTDPNGDYIR 2 1 RYLPVLRGFPAKYIYDPWNAPEGIQKVAKCLIGVNYPKPMVNHEASLNIERMKQIYQQLSRYRGL 1 2 GLLASVPSNPNGNGGLMAyAPGENIPGCSSSG 1 2 SCTQGSSILHNAHGDSQQTHLLKQ 1 2 GRSSMGTGLSSGKRPSQEEDTQSIGPKVQRQSTN* 0 >CRY1_oryCun Oryctolagus cuniculus (rabbit) 0 MGVNAVHWFRKGLRLHDNPALKECIQGADTIRCVYILDPWFAGSSNVGINRW 2 1 RFLLQCLEDLDANLRKLNSRLFVIRGQPADVFPRLFK 0 0 EWNITRLSIEYDSEPFGKERDAAIKKLASEAGVEVIVRISHTLYDLDK 2 1 IIELNGGQPPLTYKRFQTLISKMEPLEIPVETITSDVIEKCTTPVSDDHDEKYGVPSLEEL 1 2 GFDTDGLSSAVWPGGETEALTRLERHLERK 0 0 AWVANFERPRMNANSLLASPTGLSPYLRFGCLSCRLFYFKLTDLYKK 0 0 VKKNSSPPLSLYGQLLWREFFYTAATNNPRFDKMEGNPICVQIPWDKNPEALAKWAEGQTGFPWIDAIMTQLRQEGWIHHLARHAVACFLTRGDLWISWEEGMK 0 0 VFEELLLDADWSINAGSWMWLSCSSFFQQFFHCYCPVGFGRRTDPNGDYIR 2 1 RYLPVLRGFPAKYIYDPWNAPEGIQKVAKCLIGINYPKPMVNHAEASRLNIERMKQIYQQLSRYRGL 1 2 GLLASVPSNPNGNGGLMGYSPGENIPGCSSSG 1 2 SCSQGSGILHYAQGDTQQTQLLKQ 1 2 GRSSMGTGLSSGKRPSQEEDTQSIGPKVQRQSTN* 0 >CRY1_oviAri Ovis aries (sheep) NM_001129735 19341811 19150926 0 MGVNAVHWFRKGLRLHDNPALKECIQGADTIRCVYILDPWFAGSSNVGINRWR 2 1 FLLQCLEDLDANLRKLNSRLFVIRGQPADVFPRLFK 0 0 EWNITKLSIEYDSEPFGKERDAAIKKLATEAGVEVIIRISHTLYDLDK 2 1 IIELNGGQPPLTYKRFQTLISKMEPLEIPVETITSEVMEKCTTPLSDDHDEKYGVPSLEEL 1 2 GFDTDGLPSAVWPGGETEALTRLERHLERK 0 0 AWVANFERPRMNANSLLASPTGLSPYLRFGCLSCRLFYFKLTDLYKK 0 0 VKKNSSPPLSLYGQLLWREFFYTAATNNPRFDKMEGNPICVQIPWDKNPEALAKWAEGRTGFPWIDAIMTQLRQEGWIHHLARHAVACFLTRGDLWISWEEGMK 0 0 VFEELLLDADWSINAGSWMWLSCSSFFQQFFHCYCPVGFGRRTDPNGDYIR 2 1 RYLPVLRGFPAKYIYDPWNAPEGIQKVAKCLIGVNYPKPMVNHAEASRLNIERMKQIYQQLSRYRG 1 2 GLLASVPSNPNGNGGLMGYSPGENIPGCSSSA 1 2 SCTQGSGILHYAHGDSQQTHLLKQ 1 2 GRSSTAAGLGSGKRPSQEEDTQSVGPKVQRQSTN* 0 >CRY1_bosTau Bos taurus (cow) NM_001105415 XM_616063 0 MGVNAVHWFRKGLRLHDNPALKECIQGADTIRCVYILDPWFAGSSNVGINRWR 2 1 FLLQCLEDLDANLRKLNSRLFVIRGQPADVFPRLFK 0 0 EWNITKLSIEYDSEPFGKERDAAIKKLATEAGVEVIVRISHTLYDLDK 2 1 IIELNGGQPPLTYKRFQTLISKMEPLEIPVETITSEVIEKCTTPLSDDHDEKYGVPSLEEL 1 2 GFDTDGLPSAVWPGGETEALTRLERHLERK 0 0 AWVANFERPRMNANSLLASPTGLSPYLRFGCLSCRLFYFKLTDLYKK 0 0 VKKNSSPPLSLYGQLLWREFFYTAATNNPRFDKMEGNPICVQIPWDKNPEALAKWAEGRTGFPWIDAIMTQLRQEGWIHHLARHAVACFLTRGDLWISWEEGMK 0 0 VFEELLLDADWSINAGSWMWLSCSSFFQQFFHCYCPVGFGRRTDPNGDYIR 2 1 RYLPVLRGFPAKYIYDPWNAPEGIQKVAKCLIGVNYPKPMVNHAEASRLNIERMKQIYQQLSRYRGL 1 2 GLLASVPSNPNGNGGLMGYSPGENIPGCSSNA 1 2 SCTQGSGILHYAHGDSQQTHLLKQ 1 2 GRSSTGAGLGSGKRPSQEEDTQSIGPKVQRQSTN* 0 + >CRY1_susScr Sus scrofa (pig) XM_003126079 0 MGVNAVHWFRKGLRLHDNPALKECIQGADTIRCVYILDPWFAGSSNVGINRWR 2 1 FLLQCLEDLDANLRKLNSRLFVIRGQPADVFPRLFK 0 0 EWNITKLSIEYDSEPFGKERDAAIKKLATEAGVEVIVRISHTLYDLDK 2 1 IIELNGGQPPLTYKRFQTLISKMEPLEIPVETITSEVIEKCTTPLSDDHDEKYGVPSLEEL 1 2 GFDTDGLPSAVWPGGETEALTRLERHLERK 0 0 AWVANFERPRMNANSLLASPTGLSPYLRFGCLSCRLFYFKLTDLYKK 0 0 VKKNSSPPLSLYGQLLWREFFYTAATNNPRFDKMEGNPICVQIPWDKNPEALAKWAEGRTGFPWIDAIMTQLRQEGWIHHLARHAVACFLTRGDLWISWEEGMK 0 0 VFEELLLDADWSINAGSWMWLSCSSFFQQFFHCYCPVGFGRRTDPNGDYIR 2 1 RYLPVLRGFPAKYIYDPWNAPEGIQKVAKCLIGVNYPKPMVNHAEASRLNIERMKQIYQQLSRYRGL 1 2 GLLASVPSNPNGNGGLMGYSPGENIPGCSSSG 1 2 SCPQGSGILHYAHGESQQNHLLKQ 1 2 GRSSTGSGLSSAKRPSQEEDTQSIIGPKVQRQSTN* 0 >CRY1_ailMel Ailuropoda melanoleuca (panda) XM_002927658 0 MGVNAVHWFRKGLRLHDNPALKECIQGADTIRCVYILDPWFAGSSNVGINRWR 2 1 FLLQCLEDLDANLRKLNSRLFVIRGQPADVFPRLFK 0 0 EWNITKLSIEYDSEPFGKERDAAIKKLATEAGVEVIVRISHTLYDLDK 2 1 IIELNGGQPPLTYKRFQTLISKMEPLEIPVETITSEVIEKCTTPLSDDHDEKYGVPSLEEL 1 2 GFDTDGLPSAVWPGGETEALTRLERHLERK 0 0 AWVANFERPRMNANSLLASPTGLSPYLRFGCLSCRLFYFKLTDLYKK 0 0 VKKNSSPPLSLYGQLLWREFFYTAATNNPRFDKMEGNPICVQIPWDKNPEALAKWAEGRTGFPWIDAIMTQLRQEGWIHHLARHAVACFLTRGDLWISWEEGMK 0 0 VFEELLLDADWSINAGSWMWLSCSSFFQQFFHCYCPVGFGRRTDPNGDYIR 2 1 RYLPVLRGFPAKYIYDPWNAPEGIQKVAKCLIGVNYPKPMVNHAEASRLNIERMKQIYQQLSRYRGL 1 2 GLLASVPANPNGNGGLMGYSPGENIPGCSSSG 1 2 SCSQGSGILHYAHGDSQQTHLLKQ 1 2 GRSSMGSGLSSGKRPSEEEDTQSIGPKVQRQSTN* 0 >CRY1_loxAfr Loxodonta africana (elephant) XM_003405313 0 MGVNAVHWFRKGLRLHDNPALKECIQGADTIRCVYILDPWFAGSSNVGINRWR 2 1 FLLQCLEDLDANLRKLNSRLFVIRGQPADVFPRLFK 0 0 EWDITKLSIEYDSEPFGKERDAAIKKLATEAGVEVIVRISHTLYDLDK 2 1 IIELNGGQPPLTYKRFQTLISKMEPLEIPVETITSEVIGKCTTPLSDDHDEKYGVPSLEEL 1 2 GFDTDGLPSAVWPGGETEALTRLERHLERK 0 0 AWVANFERPRMNANSLLASPTGLSPYLRFGCLSCRLFYFKLTDLYKK 0 0 VKKNSSPPLSLYGQLLWREFFYTAATNNPRFDKMEGNPICVQIPWDKNPEALAKWAEGRTGFPWIDAIMTQLRQEGWIHHLARHAVACFLTRGDLWISWEEGMK 0 0 VFEELLLDADWSINAGSWMWLSCSSFFQQFFHCYCPVGFGRRTDPNGDYIR 2 1 RYLPVLRGFPAKYIYDPWNAPEGIQKVAKCLIGVNYPKPMVNHAEASRLNIERMKQIYQQLSRYRGL 1 2 GLLASVPSNPNGNGGLMGYSPGENTPGCNSSG 1 2 SCSQGSGILHYVHGDSLLKQ 1 2 GRSPTGTGVSSGKRPSQDEETQTLGPKVQRQSTN* 0 >CRY1_monDom Monodelphis domestica (opossum) XM_003341966 0 MGVNAGHWFRKRLRLPHNPALKGCIQGADTVCCVYIRDPWFGGSSNFGANEWK 2 1 FLLQCLEDLDANLRKLNSRLFVIRGQPADVFPRLFK 0 0 EWNIAKLSIEYDSEPFGKERDAAIKKLASEAGVEVIVRISHTLYDLDK 0 0 IIELNGGQPPLTYKRFQTLISKMEPLATPVETITPEVMHKCVTPLSDEHDEKYGVPSLEEL 1 2 GFDTDGLPSAVWPGGETEALTRLERHLERK 0 0 AWVANFERPRMNANSLLASPTGLSPYLRFGCLSCRLFYFKLTDLYKK 0 0 VKKNSSPPLSLYGQLLWREFFYTAATNNPRFDKMEGNPICVQIPWDRNPEALAKWAEGRTGFPWIDAIMTQLRQEGWIHHLARHAVACFLTRGDLWISWEEGMK 0 0 VFEELLLDADWSINAGSWMWLSCSSFFQQFFHCYCPVGFGRRTDPNGDYIR 2 1 RYLPVLRGFPAKYIYDPWNAPEGIQKVAKCLIGVNYPKPMVNHAEASRLNIERMKQIYQQLSRYRGL 1 2 GLLASVPSNPNGNGSLMAYTPGENIPGCSSGG 1 2 GYSQGSGISHYSHEDSQQAYMLKQ 1 2 GRSSLGVGGGKRPRQEEETQSINPKVQRQSTN* 0 >CRY1_macEug Macropus eugenii (wallaby) assembly frameshift 0 MGVNAVHWFRKGLRLHDNPALKECIEGADTVRCVYILDPWFAGSSNVGINRWR 2 1 FLLQCLEDLDANLRKLNSRLFVIRGQPADVFPRLFK 0 0 EWNITKLSIEYDSEPLGRNAMQLLKNWASEAGVEVIVRISHTLYDLDK 2 1 1 2 gFDTDGLPSAVWPGGETEALTRLERHLERK 0 0 AWVANFERPRMNANSLLASPTGLSPYLRFGCLSCRLFYFKLTDLYKK 0 0 VKKNSSPPLSLYGQLLWREFFYTAATNNPRFDKMEGNPICVQIPWDRNPEALAKWAEGRTGFPWIDAIMTQLRQEGWIHHLARHAVACFLTRGDLWISWEEGMK 0 0 VFEELLLDADWSINAGSWMWLSCSSFFQQFFHCYCPVGFGRRTDPNGDYIR 2 1 RYLPVLRGFPAKYIYDPWNAPEGVQKVAKCLIGVNYPKPMVNHAEASRLNIERMKQIYQQLSRYRGL 1 2 GLLASVPSNPNGNGSLMGYTTGENIPTCSSSGG 1 2 GYSQGSGISHYSHEDSQQAYVLKQ 1 2 GRNSLGGGKRHRQEEETQSIGSKMQRQSVN* 0 >CRY1_sarHar Sarcophilus harrisii (tasmanian_devil) nearly identical to oppossum 0 2 1 FLLQCLEDLDANLRKLNSRLFVIRGQPADVFPRLFK 0 0 EWNIAKLSIEYDSEPFGKERDAAIKKLASEAGVEVIVRISHTLYDLDK 0 0 1 2 GFDTDGLPSAVWPGGETEALTRLERHLERK 0 0 AWVANFERPRMNANSLLASPTGLSPYLRFGCLSCRLFYFKLTDLYKK 0 0 VKKNSSPPLSLYGQLLWREFFYTAATNNPRFDKMEGNPICVQIPWDRNPEALAKWAEGRTGFPWIDAIMTQLRQEGWIHHLARHAVACFLTRGDLWISWEEGMK 0 0 VFEELLLDADWSINAGSWMWLSCSSFFQQFFHCYCPVGFGRRTDPNGDYIR 2 1 RYLPVLRGFPAKYIYDPWNAPEGIQKVAKCLIGVNYPKPMVNHAEASRLNIERMKQIYQQLSRYRGL 1 2 GLLASVPSNPNGNGGLMGYTSGENGPACNSGG 1 2 GYSQGSGISHYSHEDSQQAYILKQ 1 2 GRSSLSGGKRPRQEEETQSVGPKVQRQSVN* 0 >CRY1_ornAna Ornithorhynchus anatinus (platypus) XM_001508563 = rubbish, genomic frameshift, continuing exon 12 0 MGVNAVHWFRKGLRLHDNPALRDCVRGADTVRCVYILDPWFAGSSNVGINRWR 2 1 FLLQCLEDLDANLRKLNSRLFVIRGQPADVFPRLFK 0 0 EWNIAKLSIEYDSEPFGKERDAAIKKLASEAGVEVIVRISHTLYELDK 2 1 IIELNGGQPPLTYKRFQTLISRMDPLAMPVETITAEVMGKCMTPLSDDHDEKYGVPSLEEL 1 2 GFDTDGLPSAVWPGGETEALTRLERHLERK 0 0 AWVANFERPRMNANSLLASPTGLSPYLRFGCLSCRLFYFKLTDLYKK 0 0 VKKNSSPPLSLYGQLLWREFFYTAATSNPRFDKMEGNPICVQIPWDRNPEALAKWAEGRTGFPWIDAIMTQLRQEGWIHHLARHAVACFLTRGDLWISWEEGMK 0 0 VFEELLLDADWSVNAGSWMWLSCSSFFQQFFHCYCPVGFGRRTDPNGDYIR 2 1 RYLPVLRGFPAKYIYDPWNAPEGIQKAAKCIIGVNYPKPMVNHAEASRLNIERMKQIYQQLSRYRGL 1 2 GLLASVPSNPNANGSGGLMAYSPGENIPGCSSGGG 1 2 GVQMGASESH LLQTCVLGESHLGPSGIQQQ 1 2 GYCQGSGVLYYANGESHLTQ 1 2 GRSSLTPGLSGGKRPCQEEESQSIGPKVQRQSTD* 0 >CRY1_tacAcu Tachyglossus aculeatus (echidna) SRR000649.130490 short read transcripts corrected for frameshifts, skipped penultimate exon 0 2 1 0 0 2 1 ETITAEVMGKCVTPLSDDHDEKYGVPSLEEL 1 2 GFDTDGLPSAVWPGGEAEALTRLERHLERK 0 0 AWVANFERPRMNANSLLASPTGLTPYLRFGCLSCRLFYFKLTDLYKK 0 0 VKKNSSPPLSLYGQLLWREFFYTAATSNPRFDKMEGNPICVQIPWDRNPEALAKWAEGRTGFPWIDAImtqlrqeGWIHHLARHAVACFLTRGDLWISWEEGMK 0 0 VFEELLLDADWSVNAGSWMWLSCSSFFQQFFHCYCPVGFGRRTDPNGDYIR 2 1 RYLPVLRGFPAKYIYDPWNAPEGIQKAAKCIIGVNYPKPMVNHAEASRLNIERMKQIYQQLSRYRGL 1 2 GLLASVPSNPNANGSGGLMAYSPGENIPGCSSGG 1 2 GAQIGASESHLLQTCVLGESHLGPSGIQQQ 1 2 1 2 GRSSLTPGLSGGKRHCQEEESQSIGPKVQRQSTD* 0 >CRY1_galGal Gallus gallus (chicken) 11684328 17324421 15459395 0 MGVNAVHWFRKGLRLHDNPALRECIRGADTVRCVYILDPWFAGSSNVGINRWR 2 1 FLLQCLEDLDANLRKLNSRLFVIRGQPADVFPRLFK 0 0 EWSIAKLSIEYDSEPFGKERDAAIKKLASEAGVEVIVRISHTLYDLDK 2 1 IIELNGGQPPLTYKRFQTLISRMEPLEMPVETITPEVMQKCTTPVSDDHDEKYGVPSLEEL 1 2 GFDTDGLPSAVWPGGETEALTRLERH 0 0 LERKAWVANFERPRMNANSLLASPTGLSPYLRFGCLSCRLFYFKLTDLYKK 0 0 VKKNSSPPLSLYGQLLWREFFYTAATNNPRFDKMEGNPICVQIPWDKNPEALAKWAEGRTGFPWIDAIMTQLRQEGWIHHLARHAVACFLTRGDLWISWEEGMK 0 0 VFEELLLDADWSVNAGSWMWLSCSSFFQQFFHCYCPVGFGRRTDPNGDYIR 2 1 RYLPVLRGFPAKYIYDPWNAPESVQKAAKCVIGVNYPKPMVNHAEASRLNIERMKQIYQQLSRYRGL 1 2 GLLATVPSNPNGNGNGGLMSFSPGESISGCSSAG 1 2 GAQLGTGDGQTVGVQTCALADSHTGGSGVQQQ 1 2 GYCQASSILRYAHGDNQQSHLMQP 1 2 GRASLGTGISAGKRPNPEEETQSVGPKVQRQSTN* 0 >CRY1_melGal Meleagris gallopavo (turkey) XM_003202363 0 2 1 FLLQCLEDLDANLRKLNSRLFVIRGQPADVFPRLFK 0 0 EWSIAKLSIEYDSEPFGKERDAAIKKLASEAGVEVIVRISHTLYDLDK 2 1 IIELNGGQPPLTYKRFQTLISRMEPLEMPVETITPEVMQKCTTPVSDDHDEKYGVPSLEEL 1 2 GFDTDGLPSAVWPGGETEALTRLERH 0 0 LERKAWVANFERPRMNANSLLASPTGLSPYLRFGCLSCRLFYFKLTDLYKK 0 0 VKKNSSPPLSLYGQLLWREFFYTAATNNPRFDKMEGNPICVQIPWDKNPEALAKWAEGRTGFPWIDAIMTQLRQEGWIHHLARHAVACFLTRGDLWISWEEGMK 0 0 VFEELLLDADWSVNAGSWMWLSCSSFFQQFFHCYCPVGFGRRTDPNGDYIR 2 1 RYLPVLRGFPAKYIYDPWNAPESVQKAAKCVIGVNYPKPMVNHAEASRLNIERMKQIYQQLSRYRGL 1 2 GLLATVPSNPNGNGNGGLMSFSPGESISGCSSAG 1 2 GAQLGTGDGQTVGVQSCALGDSHTGGNGVQQQ 1 2 GYCQASSILRYAHGDNQQPHLMQP 1 2 GRASLGTGISAGKRPNPEEETQSVGPKVQRQSTN* 0 >CRY1_eriRub Erithacus rubecula (robin) AY585716 0 MGVNAVHWFRKGLRLHDNPALRECIRGADTVRCVYILDPWFAGSSNVGINRWR 2 1 FLLQCLEDLDANLRKLNSRLFVIRGQPADVFPRLFK 0 0 EWNIAKLSIEYDSEPFGKERDAAIKKLASEAGVEVIVRISHTLYDLDK 2 1 IIELNGGQPPLTYKRFQTLISRMEPLEMPVETITPEVMKKCTTPVFDDHDEKYGVPSLEEL 1 2 GFDTDGLPSAVWPGGETEALTRLERHLERK 0 0 ASVANFERPRMNANSLLASPTGLSPYLRFGCLSCRLFYFKLTDLYKK 0 0 VKKNSSPPLSLYGQLLWREFFYTAATNNPRFDKMEGNPICVQIPWDKNPEALAKWAEGRTGFPWIDAIMTQLRQEGWIHHLARHAVACFLTRGDLWISWEEGMK 0 0 VFEELLLDADWSVNAGSWMWLSCSSFFQQFFHCYCPVGFGRRTDPNGDYIR 2 1 RYLPVLRGFPAKYIYDPWNAPESIQKAAKCIIGVNYPKPMVNHAEASRLNIERMKQIYQQLSRYRGL 1 2 GLLATVPSNPNGNGNGGLMGYSPGESISGCGSTG 1 2 GAQLGTGDGHTVVQSCTLGDSHSGTSGIQQQ 1 2 GYCQASSILHYAHGDNQQSHLLQA 1 2 GRTALGTGISAGKRPNPEEETQSVGPKVQRQSTN* 0 >CRY1_sylBor Sylvia borin (warbler) AJ632120 15381765 0 MGVNAVHWFRKGLRLHDNPALRECIQGADTVRCVYILDPWFAGSSNVGINRWR 2 1 FLLQCLEDLDANLRKLNSRLFVIRGQPADVFPRLFK 0 0 EWNIAKLSIEYDSEPFGKERDAAIKKLASEAGVEVIVRISHTLYDLDK 2 1 IIELNGGQPPLTYKRFQTLISRMEPLEMPVETITPEVMKKCTTPVSDDHDEKYGVPSLEEL 1 2 GFDTDGLPSAVWPGGETEALTRLERHLERK 0 0 AWVANFERPRMNANSLLASPTGLSPYLRFGCLSCRLFYFKLTDLYKK 0 0 VKKNSSPPLSLYGQLLWREFFYTAATNNPRFDKMEGNPICVQIPWDKNPEALAKWAEGRTGFPWIDAIMTQLRQEGWIHHLARHAVACFLTRGDLWISWEE 0 0 VFEELLLDADWSVNAGSWMWLSCSSFFQQFFHCYCPVGFGRRTDPNGDYIR 2 1 RYLPVLRGFPAKYIYDPWNAPESIQKAAKCIIGVNYPKPMVNHAEASRLNIERMKQIYQQLSRYRGL 1 2 GLLATVPSNPNGNGNGGLMGYSPGESISGCGSTG 1 2 GAQLGAGDGHSVVQSCALGDSHTGTSGVQQQ 1 3 GYCQASSILHYAHGDNQQSHLLQA 1 2 GRTALGTGISAGKRPNPEEETQSVGPKVQRQSTN* 0 >CRY1_taeGut Taeniopygia guttata (finch) XM_002196518 0 2 1 FLLQCLEDLDANLRKLNSRLFVIRGQPADVFPRLFK 0 0 EWNIAKLSIEYDSEPFGKERDAAIKKLASEAGVEVIVRISHTLYDLDK 0 0 IIELNGGQPPLTYKRFQTLISRMEPLEMPVETITPEVMKKCTTPVSDDHDEKYGVPSLEEL 1 2 GFDTDGLPSAVWPGGETEALTRLERHLERK 0 0 AWVANFERPRMNANSLLASPTGLSPYLRFGCLSCRLFYFKLTDLYKK 0 0 VKKNSSPPLSLYGQLLWREFFYTAATNNPRFDKMEGNPICVQIPWDKNPEALAKWAEGRTGFPWIDAIMTQLRQEGWIHHLARHAVACFLTRGDLWISWEEGMK 0 0 GMKVFEELLLDADWSVNAGSWMWLSCSSFFQQFFHCYCPVGFGRRTDPNGDYIR 2 1 RYLPVLRGFPAKYIYDPWNAPESIQKAAKCIIGVNYPKPMVNHAEASRLNIERMKQIYQQLSRYRGL 1 2 GLLATVPSNPNGNGNGGLMGYSPGESISGCGSTG 1 2 GAQLGTGDGHSVVQSCALGDSHTGTSGIQQQ 1 2 GYCQASSILHYAHGDNQQSHLLQA 1 2 GRTALGTGISAGKRPNPEEETQSVGPKVQRQSTN* 0 >CRY1_melUnd Melopsittacus undulatus (budgerigar) AGAI01062111 1 RYLPVLRGFPAKYIYDPWNAPESIQKAAKCIIGVNYPKPMVNHAEASRLNIERMKQIYQQLSRYRGL GLLATVPSNPNGNGNGGLMGYSPGESISGCSSAGG GAQLGTGDGHTVVQPCALGDSHTAGASGIQQQ GYCQASSILHYAHGDNQQSHLLQAG VGTGISAGKRPNPEEETQSVGPKVQRQSTN* 0 >CRY1_allMis Alligator mississippiensis (alligator) genome/blat 0 MGVNAVHWFRKGLRLHDNPALRECIQGADTVRCVYILDPWFAGSSNVGINRWR 2 1 FLLQCLEDLDANLRKLNSRLFVIRGQPADVFPRLFK 0 0 EWNITKLSIEYDSEPFGKERDAAIKKLASEAGVEVIVRISHTLYDLDK 2 1 IIELNGGQPPLTYKRFQTLISRMEPLEMPVETITAEVMKKCTTPVSDDHDEKYGVPSLEEL 1 2 GFDTDGLPSAVWPGGETEALTRLERHLERK 0 0 AWVANFERPRMNANSLLASPTGLSPYLRFGCLSCRLFYFKLTDLYKK 0 0 VKKNSSPPLSLYGQLLWREFFYTAATNNPRFDKMEGNPICVQIPWDKNPEALAKWAEGRTGFPWIDAIMTQLRQEGWIHHLARHAVACFLTRGDLWISWEEGMK 0 0 VFEELLLDADWSVNAGSWMWLSCSSFFQQFFHCYCPVGFGRRTDPNGDYIR 2 1 RYLPVLRGFPAKYIYDPWNAPEGVQKAAKCIIGVNYPKPMVNHAEASRLNIERMKQIYQQLSRYRGL 1 2 GLLATVPSNPNGNGNGGLMGYSPGENVSGCGSTG 1 2 GAQMGSSDGHTVSVQPCALGESHGGSNGIQQQ 1 3 GYFQASSILHFPHGDDQQSHLLQQ 1 2 GRTSLSSGISAGKRPNPEEETQSIGPKVQRQSTN* >CRY1_anoCar Anolis carolinensis (lizard) XM_003220923 0 MGVNAVHWFRKGLRLHDNPALREVIQGADTVRCVYILDPWFAGSSNVGINRWR 2 1 FLLQCLEDLDANLRKLNSRLFVIRGQPADVFPRLFK 0 0 EWNITKLSIEYDSEPFGKERDAAIKKLASEAGVEVIVRISHTLYELDK 2 1 IIELNGGQPPLTYKRFQTLISRMEPLEIPVETITAEVMSKCTTPVSDDHDEKYGVPSLEEL 1 2 GFDTDGLPSAVWPGGETEALTRLERHLERK 0 0 AWVANFERPRMNANSLLASPTGLSPYLRFGCLSCRLFYFKLTDLYKK 0 0 VKKNSSPPLSLYGQLLWREFFYTAATNNPRFDKMEGNPICVQIPWDRNPEALAKWAEGRTGFPWIDAIMTQLRQEGWIHHLARHAVACFLTRGDLWISWEEGMK 0 0 VFEELLLDADWSVNAGSWMWLSCSSFFQQFFHCYCPVGFGRRTDPNGDYIR 2 1 RYLPVLRGFPAKYIYDPWNAPDGVQKAAKCIIGVNYPKPMVNHAEASRLNIERMKQMYQQLSRYRGL 1 2 GLLASVPSNGNGNGNGGLMGYSTGENIPGCTNTN 1 2 GSQMGMNEGHIGNVQACTMGESHTGTSGIQQQ 1 2 GYSQGSGILLYSHGDNQKTHSAQKGRISLGT 1 2 GVCTGKRPSPEVETQSVGPKVQRQSSN* 0 >CRY1_podSic Podarcis siculus (wall_lizard) DQ376040 16809482 0 MGVNAVHWVRQGLRLPDNRALREVIQGADTARCVYILDPSFAGSSNVGINRWR 2 1 FLLQCLEDLDANLRKLNSRLFVIRGQPADVFPRLFK 0 0 EWNITKLSIEYDSEPFGKERDAAIKKLASEAGVEVIVRISHTLYDLDK 2 1 IIELNGGQPPLTYKRFQTLISRMEPLEMPVETITAEVMSKCTTPVSDDHDEKCGVPSLEEL 1 2 GFDTGGLPSAVWPGGETEALTRLERHLERK 0 0 AWVANFERPRMNANSLLASPTGLSPYLRFGCLSCRLFYFKLTDLYKK 0 0 VKKNSSPPLSLYGQLLWREFFYTAATNNPRFDKMEGNPICVQIPWDRNPEALAKWAEGRTGFPWIDAIMTQLRQEGWIHHLARRAVACFLTRGDLWISWEEGMK 0 0 VFEELLLDADWSVNAGSWMWLSCSSFFQQFFHCYCPVGFGRRTDPNGDYIR 2 1 RYLPVLRGFPAKYIYDPWNAPEGVQKVAKCVIGVNYPKPMVNHTEASRLNIERMKQIYQQLSRYRGL 1 2 GLLASVPLMEWNVIVLMGYHQGTLLVYHAS 1 2 GSQMGTNEAHTGSVQTCTLGESHTGTSGIQQQ 1 2 GYPQGSDILHYAHGEGQKTHLIQQGRASLVA 1 2 GVCTGKRPNPEEETQSIGPKVQRQSSK* 0 >CRY1_pytMol Python molurus (python) AEQU010547455 0 MGVNSVHWFRKGLRLHDNPALREVIQGADTVRCVYILDPWFAGSSNVGINRWR 2 1 FLLQCLEDLDANLRKLNSRLFVIRGQPADVFPRLFk 0 0 EWNISKLSIEYDSEPFGKERDAAIKKLATEAGLEVIVRISHTLYDLDK 2 1 IIELNGGQPPLTYKRFQTLISRMEPLEMPVETITAEVMSKCTTPVSDDHDEKYGVPSLEEL 1 2 GFDTDGLPSAVWPGGETEALTRLERHLER 0 0 AWVANFERPRMNANSLLASPTGLSPYLRFGCLSCRLFYFKLTDLYKK 0 0 VKKNSSPPLSLYGQLLWREFFYTAATNNPRFDKMEGNPICVQIPWDKNPEALAKWAEGRTGFPWIDAIMTQLRQEGWIHHLARHAVACFLTRGDLWISWEEGMK 0 2 VFEELLLDADWSVNAGSWMWLSCSSFFQQFFHCYCPVGFGRRTDPNGDYIR 2 1 RYLPILRGFPAKYIYDPWNAPEGVQKAAKCIIGINYPKPMVNHAEASRLNIERMKQIYQQLSRYRGL 2 1 2 GAQMGTSEGHTGNVQACTLGETHTGTSGIQQQ 1 2 GYSQGNSGILHYAHGDSQKTLLMQ 1 2 GRTSLSVGVCTGKRPNPEEGIQSIGPKVQRQSSN* 0 >CRY1_chrPic Chrysemys picta (turtle) AHGY01469963 AHGY01469969 0 MGVNAVHWFRKGLRLHDNPALRECIQGADSVRCVYILDPWFAGSSNVGINRWR 2 1 FLLQCLEDLDANLRKLNSRLFVIRGQPADVFPRLFK 0 0 EWNIAKLSIEYDSEPFGKERDAAIKKLASEAGVEVIVRISHTLYDLDK 2 1 IIELNGGQPPLTYKRFQTLISRMEPLEMPVETITAEVMEKCTTPVSDDHDEKYGVPSLEEL 1 2 GFDTDGLPSAVWPGGETEALTRLERHLERK 0 0 AWVANFERPRMNANSLLASPTGLSPYLRFGCLSCRLFYFKLTDLYKK 0 0 VKKNRSPPLSLYGQLLWREFFYTAATNNPRFDKMEGNPICVQIPWDRNPEALAKWAEGRTGFPWIDAIMTQLRQEGWIHHLARHAVACFLTRGDLWISWEEGMK 0 0 VFEELLLDADWSVNAGSWMWLSCSSFFQQFFHCYCPVSFGRRTDPNGDYIR 2 1 RYLPILRGFPAKYIYDPWNAPESIQKAAKCVIGVHYPKPMVNHAEASRLNIERMKQIYQQLSRYRGL 1 2 GLLATVPSNP NGNGGLMGYSPGENISGCSSAS 1 2 GAQMGSNDGHTVGVQTCSLEDSHAGSSGIQQH 1 2 GYSQGNSIVHYAQGDHQQSHLLQQG 1 2 GRTVSTGISTGKRPNPEKETQSIGPKVQRQSTN* 0 >CRY1_xenTro Xenopus tropicalis (frog) NM_001087660 11533577 final four exons confirmed by many ESTs 0 MGVNAVHWFRKGLRLHDNPALRECIQGADTVRCVYILDPWFAGSSNVGINRWR 2 1 FLLQCLEDLDANLRKLNSRLFVIRGQPADVFPRLFK 0 0 EWKITKLSIEYDSEPFGKERDAAIKKLASEAGVEVIVRISHTLYDLDK 2 1 IIELNGGQPPLTYKRFQTLISKMDPLEIPVETITAEVMEKCTTPVSDDHDEKYGVPSLEEL 1 2 GFDTEGLPSAVWPGGETEALTRLERHLERK 0 0 AWVANFERPRMNANSLLASTTGLSPYLRFGCLSCRLFYFKLTDLYKK 0 0 VKKNSSPPLSLYGQLLWREFFYTAATNNPRFDKMDGNPICVQIPWDRNPEALAKWAEGRTGFPWIDAIMTQLRQEGWIHHLARHAVACFLTRGDLWISWEEGMK 0 0 VFEELLLDADWSVNAGSWMWLSCSSFFQQFFHCYCPVGFGKRTDPNGDYIR 2 1 RYLPILKGFPPKYIYDPWNAPETVQKAAKCIIGVNYPKPMVNHAEASRLNIERMKQIYQQLSRYRGL 1 2 GLLASVPSNPNGNGNGGLMSYSPGESMSGCSNNG 1 2 GGQMGVNEGSSASNPNANKGEVHPGTSGLQ 1 2 GYWQGSSILHYSHSDSQQSYLMQ 1 2 ARNPLHSVVSSGKRPNPEEETQSIGPKVQRQSSH* 0 >CRY1_latCha Latimeria chalumnae (coelocanth) 0 MGVNAIHWFRKGLRLHDNPALREAIQGGDCIRCVYILDPWFAGSSNVGINRWR 2 1 FLLQCLEDLDANLRKLNSRLFVIRGQPADVFPRLFK 0 0 EWNISRLSFEYDSEPFGKERDAAIKKLASEAGVEVIVRITHTLYDLDR 2 1 IIELNGGQPPLTYKRFQTLISRMEPLDLPVETINSEVMGNCSTPVSDDHDEKYGVPSLEEL 1 2 GFDTEGLPSAVWPGGETEALTRLERHLERK 0 0 AWVANFERPRMNANSLLASPTGLSPYLRFGCLSCRLFYFKLTDLYKK 0 0 VKKNSSPPLSLYGQLLWREFFYTAATNNPRFDKMEGNPICVQIPWDKNPEALAKWAEGKTGFPWIDAIMTQLRQEGWIHHLARHAVACFLTRGDLWISWEEGMK 0 0 VFEELLLDADWSVNAGSWMWLSCSSFFQQFFHCYCPVGFGRRTDPNGDYIR 2 1 RYLPVLRGFPAKYIYDPWNAPEGVQKAAKCIIGVNYPKPMVNHAEASRLNIERMKQIYQQLSRYRGM 1 2 GLLASVPSNPNGNGGLGCSLAENIPVCNSAA 1 2 GAQMGGDDGHKVSVLAYTQGDSRAGEIEMQQQ gcyi* 1 2 1 2 * 0 >CRY1_danRer Danio rerio (zebrafish) NM_001077297 0 MVVNTVHWFRKGLRLHDNPSLRDSILGAHSVRCVYILDPWFAGSSNVGISRWR 2 1 FLLQCLEDLDASLRKLNSRLFVIRGQPTDVFPRLFK 0 EWNINRLSYEYDSEPFGKERDAAIKKLANEAGVEVIVRISHTLYDLDK 2 0 IIELNGGQSPLTYKRFQTLISRMEAVETPAETITAEVMGPCTTPLSDDHDEKFGVPSLEEL 1 2 GFDTEGLSSAVWPGGETEALTRLERHLERK 0 0 AWVANFERPRMNANSLLASPTGLSPYLRFGCLSCRLFYFKLTDLYRK 0 0 VKKNSSPPLSLYGQLLWREFFYTAATNNPRFDKMEGNPICVQIPWDKNPEALAKWAEGRTGFPWIDAIMTQLRQEGWIHHLARHAVACFLTRGDLWISWEEGMK 0 0 VFEELLLDADWSVNAGSWMWLSCSSFFQQFFHCYCPVSFGRRTDPNGDYIR 2 1 RYLPVLRGFPAKYIYDPWNAPESVQKAAKCIIGVHYPMPMVHHAEASRLNIERMKQIYQQLSCYRGL 1 2 GLLAMVPSNPNGNGENSTSLMGFQTGDMTKEVTTPS 1 2 GYQMPPTSQGEWHGRTMVYSQGDQQTSSIMTSQ 1 2 GFGNNGSTMCYRQDAQQIT 1 2 GRGLHSSIIQTSGKRHSEESGPTTVSKVQRQCSS* 0 >CRY1_petMar Petromyzon marinus (lamprey) Contig24766 0 2 1 FLLQSLEDLDASLHKLNSRLFVIRGQPADVFPRLFK 0 0 EWNISRLTFEYDSEPFGKERDAAIKKLASEAGVEVLVRISHTLYNLDR 2 1 IIELNEGQAPLTYKRFQALVSRMEPPERPVGTITSEVMGPCRTPLWEDHDERYGVPSLEEL 1 2 GFDTDGLTTAVWQGGESEALTRLDRHLERK 0 0 AWVANFERPRMNANSLLASPTGLSPYLRFGCLSCRLFHYKLTELYKK 0 0 VKKNSSPPLSLYGQLLWREFFYTAATNNPKFDRMEGNPICVQIPWDRNPEALAKWAEGRTGYPWIDAIMTQLRQEGWIHHLARHAVACFLTRGDLWVSWEEGMK 0 0 VFEELLLDADWSVNAGSWMWLSCSSFFQQFFHCYCPVGFGRRTDPNGDYIR 2 2 RYIPLLRAFPAKYIYDPWNAPESVQKTARCIIGVDYPKPMANHAEASRLNIERMKQIYQHLSRYRGL 1 2 CLLASVPSCLEDLSSPMVEASLGQAGAVSGP 1 2 * 0 >CRY1_braFlo Branchiostoma floridae (amphioxus) XM_002609455 end uncertain 0 MKSTIHWFRKGLRLHDNPSLRDALQMLQPGDVWRCVYVLDPWFAGSSNVGVNRWR 2 1 FLLQCLEDLDASLRKLNSRLYVIRGQPTDVFPRLFK 0 0 EWKVSCLSFEEDSEPFGRERDMAVMKLAKEAGVKVILRTSHTLYKLQD 2 1 IIDVNGGQPPLTYKRFQAILSKMDPPDQPVDSITASTVDNLTTPIRDDHDEKFGVPSLEEL 1 2 GFDTDNLNPVVWPGGETEALTRLERHLERK 0 0 AWVASFERPKMTASSLLASPTGLSPYLRFGCLSPRLFYKKLTELYKK 0 0 VKRSNHPPLSLYGQLLWREFFYTAATNNPNFDKMVNNTICVQIPWDKNPEALAKWAE 00 GQTGFPWIDAIMAQLQQEGWIHHLARHAVACFLTRGDLWISWEEGMK 0 0 VFEELLLDADWSVNAGSWMWLSCSSFFQQFFHVYCPVNFGRRTDPNGDFIR 2 1 KYLPKLRGFPAKYIYDPWNSPESVQKAAKCII 12 GKDYPLPMVNHAETSRINVERMKQVYQQLSRYRGA 1 2 GLLATIPYPDGGNGNPTGHKKHAIVQGMERQHAERREHGQPAHVSRQHI * 0 >CRY1_strPur Strongylocentrotus purpuratus (urchin) XM_001194752 same split exons as braFlo, end of gene uncertain, partial duplicate elsewhere 0 MPKRKHRSSRRDREEKPGCLVHWFRKGLRLHDNPALKEGLKSASGFRCIYILDPWFAGSCSKGVNRWR 2 1 FLLECLEDLDSSLRKLNSRLFLIRGQPADVLPRLFK 0 0 EWKVTQLSFEEDSEPFGRTRDKAISTLAQEAGVKVISKVSHTLYDPQE 2 1 ILALNNNEPPLTYKRFQDIISLMGIPIYPAEALEAEDVEGLDTFIDPNHEDKYGIPTLEEL 1 2 GFDPEDVPPPMWIGGETEAKQRLDRHLERK 0 0 AWVANFERPRMSPASLMASPAGLSPYLRFGCLSPRTFYWKLTELYQK 0 0 VRKTTNTPLSLHGQLLWREFFFTVACNNRQFDHMVDNPICIQIPWDKNTALLNKWAN 00 GETGYPWIDAIMTQLRLEGWIHPLARHAVACFLTRGDLWISWEEGMK 0 0 VFDEYLLDADWSVNAGNWIWLSCSSFYQQFFHCYCPVKFGRRTDPNGDYVR 2 1 KYLPFLKNFPSKYIFEPWTAPIEVQEKAKCII 12 GKDYPLPIVDHAEASHRNIERMRKVYNNLSRRGGP 1 2 GILGSVPSSQAASAPPQLGKFNMSSKHGQLLCITVYYCVLLCITV* 0 >CRY1_aphVas Aphrocallistes vastus (sponge) AJ437143 PubMed:14499587 MESLSITEFSPSAPSPISSSSSPDEETDRDIVAKDIEQDVEPQGKVLLHIFNNRHLRLKDNTALYQAMAQNPDKFYAVYIFDGFDSKPVAPVRWQFLIDCLE DLKEQLNGFGLELYCFRGETIDVLATLVQAWKVKLLSINMDPDVNFTFFNEKIVKMCTINAVQLYNDMDSHRLLYLPPKYKSAIPMSKFRVLLAEAITAKQNNLESEAKIQDITPP LNPEQLSDLGNKPRLDSPLPSEIPKLNALFTEEEIAKLNFIFQGGERRTEDYLNEYREARLRDVSGDEDASPIAAKAMGISPHLRFGCITPRHLFNFLVKTIKDANYSRIKINKVL AGIMARDFALQVSQLQTIPERIISLNKICLPIPWDKNNNEIVEKLTDAQTGFPFFDAAITQLKTEGYVINEVSEALATFVTNSLLWVSWEEGQNFFSQHLICFDLAMSTHSWLEAS GSTMVTGRQKSYQDPLLFVSKKLDPNGEYIKRYLPKFINFPIEFIHKPGNASLEAQQAANCVIDIDYPKPLFEYECRNGICCKRLRVFMEVVDSAAKATKLPHVIENCSGKFP* 0
Vertebrate CRY2 reference sequences
These are pre-curated provisional sequences, taken from the UCSC 46-way genomic alignment relative to human. That results in omission of insertions in other species and missing exons in the situation where they are too diverged or lie in isolated small contigs. The final exons, being quite variable, are best determined from transcripts when available and then extended by blastx homology to species within the same clade lacking transcripts. After these corrections, the sequences are aligned and further anomalies are confirmed or discarded on a case-by-base basis.
>CRY2_homSap Homo sapiens (human) 11 exons 0 MAATVATAAAVAPAPAPGTDSASSVHWFRKGLRLHDNPALLAAVRGARCVRCVYILDPWFAASSSVGINRWR 2 1 FLLQSLEDLDTSLRKLNSRLFVVRGQPADVFPRLFK 0 0 EWGVTRLTFEYDSEPFGKERDAAIMKMAKEAGVEVVTENSHTLYDLDR 2 1 IIELNGQKPPLTYKRFQAIISRMELPKKPVGLVTSQQMESCRAEIQENHDETYGVPSLEEL 1 2 GFPTEGLGPAVWQGGETEALARLDKHLERK 0 0 AWVANYERPRMNANSLLASPTGLSPYLRFGCLSCRLFYYRLWDLYKK 0 0 VKRNSTPPLSLFGQLLWREFFYTAATNNPRFDRMEGNPICIQIPWDRNPEALAKWAEGKTGFPWIDAIMTQLRQEGWIHHLARHAVACFLTRGDLWVSWESGVR 0 0 VFDELLLDADFSVNAGSWMWLSCSAFFQQFFHCYCPVGFGRRTDPSGDYIR 2 1 RYLPKLKAFPSRYIYEPWNAPESIQKAAKCIIGVDYPRPIVNHAETSRLNIERMKQIYQQLSRYRGL 1 2 CLLASVPSCVEDLSHPVAEPSSSQAGSMSSA 1 2 GPRPLPSGPASPKRKLEAAEEPPGEELSKRARVAELPTPELPSKDA* 0 >CRY2_panTro Pan troglodytes (chimp) 0 MAATVATAAAVAPAPAPGTDGASSVHWFRKGLRLHDNPALLAAVRGARCVRCVYILDPWFAASSSVGINRWR 2 1 FLLQSLEDLDTSLRKLNSRLFVVRGQPADVFPRLFK 0 0 EWGVTRLTFEYDSEPFGKERDAAIMKMAKEAGVEVVTENSHTLYDLDR 2 1 IIELNGQKPPLTYKRFQAIISRMELPKKPVGSVTSQQMESCRAEIQENHDETYGVPSLEEL 1 2 GFPTEGLGPAVWQGGETEALARLDKHLERK 0 0 AWVANYERPRMNANSLLASPTGLSPYLRFGCLSCRLFYYRLWDLYKK 0 0 VKRNSTPPLSLFGQLLWREFFYTAATNNPRFDRMEGNPICIQIPWDRNPEALAKWAEGKTGFPWIDAIMTQLRQEGWIHHLARHAVACFLTRGDLWVSWESGVR 0 0 VFDELLLDADFSVNAGSWMWLSCSAFFQQFFHCYCPVGFGRRTDPSGDYIR 2 2 RYLPKLKAFPSRYIYEPWNAPESIQKAAKCIIGVDYPRPIVNHAETSRLNIERMKQIYQQLSRYRGL 1 2 CLLASVPSCVEDLSHPVAEPSSSQAGSMSSA 1 2 GPRPLPSGPASPKRKLEAAEEPPGEELSKRARVAELPTPELPSKDA* 0 >CRY2_gorGor Gorilla gorilla (gorilla) 0 MAATVATAAAVAPAPAPGTDGASSVHWFRKGLRLHDNPALLAAVRGARCVRCVYILDPWFAASSSVGINRWR 2 1 FLLQSLEDLDTSLRKLNSRLFVVRGQPADVFPRLFK 0 0 ------------------------------------------------ 2 1 IIELNGQKPPLTYKRFQAIISRMELPKKPVGSVTSQQMESCRAEIQENHDETYGVPSLEEL 1 2 GFPTEGLGPAVWQGGETEALARLDKHLERK 0 0 AWVANYERPRMNANSLLASPTGLSPYLRFGCLSCRLFYYRLWDLYKK 0 0 VKRNSTPPLSLFGQLLWREFFYTAATNNPRFDRMEGNPICIQIPWDRNPEALAKWAEGKTGFPWIDAIMTQLRQEGWIHHLARHAVACFLTRGDLWVSWESGVR 0 0 VFDELLLDADFSVNAGSWMWLSCSAFFQQFFHCYCPVGFGRRTDPSGDYIR 2 2 RYLPKLKAFPSRYIYEPWNAPESIQKAAKCIIGVDYPRPIVNHAETSRLNIERMKQIYQQLSRYRGL 1 2 CLLASVPSCVEDLSHPVAEPSSSQAGSVSSA 1 2 GPRPLPSGPASPKRKLEAAEEPPGEELSKRARVAELPTPELPSKDA* 0 >CRY2_ponAbe Pongo pygmaeus (orangutan) 0 MAATVATAAAVAPAPAPGTDGASSVHWFRKGLRLHDNPALLAAVRGARCVRCVYILDPWFAASSSVGINRWR 2 1 FLLQSLEDLDTSLRKLNSRLFVVRGQPADVFPRLFK 0 0 EWGVTRLTFEYDSEPFGKERDAAIMKMAKEAGVEVVTENSHTLYDLDR 2 1 IIELNGQKPPLTYKRFQAIISRMELPKKPVGSVTSQQMESCRAEIQENHDETYGVPSLEEL 1 2 GFPTEGLGPAVWQGGETEALARLDKHLERK 0 0 AWVANYERPRMNANSLLASPTGLSPYLRFGCLSCRLFYYRLWDLYKK 0 0 VKRNSTPPLSLFGQLLWREFFYTAATNNPRFDRMEGNPICIQIPWDRNPEALAKWAEGKTGFPWIDAIMTQLRQEGWIHHLARHAVACFLTRGDLWVSWESGVR 0 0 VFDELLLDADFSVNAGSWMWLSCSAFFQQFFHCYCPVGFGRRTDPSGDYIR 2 2 RYLPKLKAFPSRYIYEPWNAPESIQKAAKCIIGVDYPRPIVNHAETSRLNIERMKQIYQQLSRYRGL 1 2 CLLASVPSCVEDLSHPVAEPSSSQAGSVSSA 1 2 GPRPLPSGPASPKRKLEAAEEPPGEELSKRARVAELPTPELPSKDA* 0 >CRY2_rheMac Macaca mulatta (rhesus) CJ488220 testis 0 MAATVATAAAVAPAPAPGTDGASSVHWFRKGLRLHDNPALLAAVRGARCVRCVYILDPWFAASSSVGINRWR 2 1 FLLQSLEDLDTSLRKLNSRLFVVRGQPADVFPRLFK 0 0 EWGVTRLTFEYDSEPFGKERDAAIMKMAKEAGVEVVTENSHTLYDLER 2 1 IIELNGQKPPLTYKRFQAIISRMELPKKPVGSVTSQQMESCRAEIQENHDETYGVPSLEEL 1 2 GFPTEGLGPAVWQGGETEALARLDKHLERK 0 0 AWVANYERPRMNANSLLASPTGLSPYLRFGCLSCRLFYYRLWDLYKK 0 0 VKRNSTPPLSLFGQLLWREFFYTAATNNPRFDRMEGNPICIQIPWDRNPEALAKWAEGKTGFPWIDAIMTQLRQEGWIHHLARHAVACFLTRGDLWVSWESGVR 0 0 VFDELLLDADFSVNAGSWMWLSCSAFFQQFFHCYCPVGFGRRTDPSGDYIR 2 2 RYLPKLKGFPSRYIYEPWNAPESIQKAAKCIIGVDYPRPIVNHAETSRLNIERMKQIYQQLSRYRGL 1 2 CLLASVPSCVEDLSHPVAEPSSSQAGSVNSA 1 2 GPRPLPSGPASPKRKLEAAEEPPGEELSKRAKVAELPTPELPSKDA* 0 >CRY2_papHam Papio hamadryas (baboon) 0 MAATVATAAAVAPAPAPGTDGASSVHWFRKGLRLHDNPALLAAVRGARCVRCVYILDPWFAASSSVGINRWR 2 1 FLLQSLEDLDTSLRKLNSRLFVVRGQPADVFPRLFK 0 0 EWGVTRLTFEYDSEPFGKERDAAIMKMAKEAGVEVVTENSHTLYDLER 2 1 IIELNGQKPPLTYKRFQAIISRMELPKKPVGSVTSQQMESCRAEIQENHDETYGVPSLEEL 1 2 GFPTEGLGPAVWQGGETEALARLDKHLERK 0 0 AWVANYERPRMNANSLLASPTGLSPYLRFGCLSCRLFYYRLWDLYKK 0 0 VKRNSTPPLSLFGQLLWREFFYTAATNNPRFDRMEGNPICIQIPWDRNPEALAKWAEGKTGFPWIDAIMTQLRQEGWIHHLARHAVACFLTRGDLWVSWESGVR 0 0 VFDELLLDADFSVNAGSWMWLSCSAFFQQFFHCYCPVGFGRRTDPSGDYIR 2 2 RYLPKLKGFPSRYIYEPWNAPESIQKAAKCIIGVDYPRPIVNHAETSRLNIERMKQIYQQLSRYRGL 1 2 CLLASVPSCVEDLSHPVAEPSSSQAGSVNSA 1 2 GPRPLPSGPASPKRKLEAAEEPPGEELSKRAKVAELPTPELPSKDA* 0 >CRY2_calJac Callithrix jacchus (marmoset) 0 MAATVATAAAAVPAPAPGTDGASSVHWFRKGLRLHDNPALLAAVRGARCVRCVYILDPWFAASSSVGINRWR 2 1 FLLQSLEDLDTSLRKLNSRLFVVRGQPADVFPRLFK 0 0 EWGVTRLTFEYDSEPFGKERDAAIMKMAKEAGVEVVTENSHTLYDLDR 2 1 IIELNGQKPPLTYKRFQAIISRMELPKKPVGSVTSQQMESCRAEIQENHDETYGVPSLEEL 1 2 GFPTEGLGPAVWQGGETEALARLDKHLERK 0 0 AWVANYERPRMNANSLLASPTGLSPYLRFGCLSCRLFYYRLWDLYKK 0 0 VKRNSTPPLSLFGQLLWREFFYTAATNNPRFDRMEGNPICIQIPWDRNPEALAKWAEGKTGFPWIDAIMTQLRQEGWIHHLARHAVACFLTRGDLWVSWESGVR 0 0 VFDELLLDADFSVNAGSWMWLSCSAFFQQFFHCYCPVGFGRRTDPSGDYIR 2 2 RYLPKLKGFPSRYIYEPWNAPESIQKAAKCIIGVDYPRPIVNHAETSRLNIERMKQIYQQLSRYRGL 1 2 CLLASVPSCVEDLSHPVAEPSSSQAGSMSSA 1 2 GPRPLPSGPASPKRKLEAAEEPPGEELSKRARVAELPTPELPSKDV* 0 >CRY2_tarSyr Tarsius syrichta (tarsier) 0 ------------------------------------------------------------------------ 2 1 FLLQSLEDLDTSLRKLNSRLFVVRGQPADVFPRLFK 0 0 EWGVTRLTFEYDSEPFGKERDAAIMKMAKEAGVEVVTENSHTLYDLD- 2 2 -----------------------------------------RSEIQEKHGETYGEPSLDEL 1 2 GFPTEGLGPAVWQGGETEALARLDKHLERK 0 0 ----------------------------------------------- 0 0 VKRNSTPPLSLFGQLLWREFFYAAATNNPRFDRMEGNPICIQIPWDRNPEALAKWAEGKTGFPWIDAIMTQLRQEGWIHHLARHAVACFLTRGDLWVSWESGVR 0 0 VFDELLLDADFSVNAGSWMWLSCSAFFQQFFHCYCPVGFGRRTDPSGDYVR 2 2 RYLPRLKGFPSRYIYEPWNAPESVQKAAKCIIGVDYPRPIVNHAETSRLNIERMKQIYQQLSRYRGL 1 2 CLLASVPSCVEDLSHPVAEPSSSQAGSMSST 1 2 GPRPLPSGPASPKRKLEAAEEPPGEELSKRARVAELPTPELPSRDV* 0 >CRY2_micMur Microcebus murinus (mouse_lemur) 0 MATAVA-TAAAAPTPASSTDGASSVHWFRKGLRLHDNPALLAAVRGARCVRCVYILDPWFAASSSVGINRW- 2 2 ------------------------------------ 0 0 EWGVTRLTFEYDSEPFGKERDAAIMKMAKEAGVEVVTENSHTLYDLDR 2 1 IIELNGQKPPLTYKRFQAIISRMELPKKPVGSVTSQQMESCRAEIQENHDETYGVPSLEEL 1 2 GFPTEGLGPAVWQGGETEALARLDKHLERK 0 0 AWVANYERPRMNANSLLASPTGLSPYLRFGCLSCRLFYYRLWDLYKK 0 0 VKRNSTPPLSLFGQLLWREFFYTAATNNPRFDRMEGNPICIQIPWDRNPEALAKWAEGKTGFPWIDAIMTQLRQEGWIHHLARHAVACFLTRGDLWVSWESGVR 0 0 VFDELLLDADFSVNSGSWMWLSCSAFFQQFFHCYCPVGFGRRTDPSGDYIR 2 2 RYLPKLKGFPSRYIYEPWNAPESIQKAAKCIIGVDYPRPIVNHAETSRLNIERMKQIYQQLSRYRGL 1 2 CLLASVPSCVEDLSHPVAEPSSSQAGSMSST 1 2 GPRPLPSGPASPKRKLEAAEEPPGEELSKRARVTELPTPELPSKDA* 0 >CRY2_otoGar Otolemur garnettii (bushbaby) 0 MAAAVA---TAAQGPATSADGASSVHWFRKGLRLHDNPALLAAVRGARCVRCVYILDPWFAASSSVGINRWR 2 1 FLLQSLEDLDTSLRKLNSRLFVVRGQPADVFPRLFK 0 0 EWGVTRLTFEYDSEPFGKERDAAIMKMAKEAGVEVVTEN--------- 2 1 IIELNGQKPPLTYKRFQAIISRMELPKKPVGSVTSQQMESCRAEIQENHDETYGVPSLEEL 1 1 ------------------------------ 0 0 AWVANYERPRMNANSLLASPTGLSPYLRFGCLSCRLFYYRLWDLYKK 0 0 VKRNSTPPLSLFGQLLWREFFYTAATNNPRFDRMEGNPICIQIPWDRNPEALAKWAEGKTGFPWIDAIMTQLRQEGWIHHLARHAVACFLTRGDLWVSWESGVR 0 0 VFDELLLDADFSVNSGSWMWLSCSAFFQQFFHCYCPVGFGRRTDPSGDYIR 2 2 RYLPKLKGFPSRYIYEPWNAPESIQKAAKCIIGVDYPRPIVNHAETSRLNIERMKQIYQQLSRYRGL 1 2 CLLASVPSCMEDLSHPVAEPCSSQAGSINNT 1 2 GPRPLLSGSASPKRKLEAAEEPPGEELSKRARVTELPTPELPSKDA* 0 >CRY2_musMus Mus musculus (mouse) CF898022 0 MAAAAV-VAATVPAQSMGADGASSVHWFRKGLRLHDNPALLAAVRGARCVRCVYILDPWFAASSSVGINRWR 2 1 FLLQSLEDLDTSLRKLNSRLFVVRGQPADVFPRLFK 0 0 EWGVTRLTFEYDSEPFGKERDAAIMKMAKEAGVEVVTENSHTLYDLDR 2 1 IIELNGQKPPLTYKRFQALISRMELPKKPAVAVSSQQMESCRAEIQENHDDTYGVPSLEEL 1 2 GFPTEGLGPAVWQGGETEALARLDKHLERK 0 0 AWVANYERPRMNANSLLASPTGLSPYLRFGCLSCRLFYYRLWDLYKK 0 0 VKRNSTPPLSLFGQLLWREFFYTAATNNPRFDRMEGNPICIQIPWDRNPEALAKWAEGKTGFPWIDAIMTQLRQEGWIHHLARHAVACFLTRGDLWVSWESGVR 0 0 VFDELLLDADFSVNAGSWMWLSCSAFFQQFFHCYCPVGFGRRTDPSGDYIR 2 2 RYLPKLKGFPSRYIYEPWNAPESVQKAAKCIIGVDYPRPIVNHAETSRLNIERMKQIYQQLSRYRGL 1 2 CLLASVPSCVEDLSHPVAEPGSSQAGSISNT 1 2 GPRALSSGPASPKRKLEAAEEPPGEELTKRARVTEMPTQEPASKDS* 0 >CRY2_ratNor Rattus norvegicus (rat) DN948283 prostate 0 MAAAAVVAATVPAQSMGADGASSVHWFRKGLRLHDNPALLAAVRGARCVRCVYILDPWFAASSSVGINRWR 2 1 FLLQSLEDLDTSLRKLNSRLFVVRGQPADVFPRLFK 0 0 EWGVTRLTFEYDSEPFGKERDAAIMKMAKEAGVEVVTENSHTLYDLDR 2 1 IIELNGQKPPLTYKRFQALISRMELPKKPVGAVSSQHMENCRAEIQENHDDTYGVPSLEEL 1 2 GFPTEGLGPAVWQGGETEALARLDKHLERK 0 0 AWVANYERPRMNANSLLASPTGLSPYLRFGCLSCRLFYYRLWDLYRK 1 0 VKRNSTPPLSLFGQLLWREFFYTAATNNPRFDRMEGNPICIQIPWDRNPEALAKWAEGKTGFPWIDAIMTQLRQEGWIHHLARHAVACFLTRGDLWVSWESGVR 0 0 VFDELLLDADFSVNAGSWMWLSCSAFFQQFFHCYCPVGFGRRTDPSGDYIR 2 2 RYLPKLKGFPSRYIYEPWNAPESVQKAAKCIIGVDYPRPIVNHAETSRLNIERMKQIYQQLSRYRGL 1 2 CLLASVPSCVEDLSHPVAEPGSSQAGSISNT 1 2 GPRPLSSGPASPKRKLEAAEEPPGEELSKRARVTEMPAQEPPSKDS* 0 >CRY2_criGri Cricetulus griseus (hamster) XR_135830 0 MAAAAVVAGAPRGARVPALTMGADGASSVHWFRKGLRLHDNPALLAAVRGARCVRCVYILDPWFAASSSVGINRWR 2 1 FLLQSLEDLDTSLRKLNSRLFVVRGQPADVFPRLFK 0 0 EWGVTRLTFEYDSEPFGKERDAAIMKMAKEAGVEVVTENSHTLYDLDR 2 1 IIELNGQKPPLTYKRFQAIISRMELPKKPVGAVTSQQMENCRAEIQENHDDTYGVPSLEEL 1 2 GFPTEGLGPAVWQGGETEALARLDKHLERK 0 0 AWVANYERPRMNANSLLASPTGLSPYLRFGCLSCRLFYYRLWDLYKK 1 0 VKRNSTPPLSLFGQLLWREFFYTAATNNPRFDRMEGNPICIQIPWDRNPEALAKWAEGKTGFPWIDAIMTQLRQEGWIHHLARHAVACFLTRGDLWVSWESGVR 0 0 VFDELLLDADFSVNAGSWMWLSCSAFFQQFFHCYCPVGFGRRTDPSGDYIR 2 2 RYLPKLKGFPSRYIYEPWNAPESVQKAAKCIIGVDYPRPIVNHAETSRLNIERMKQIYQQLSRYRGL 1 2 CLLASVPSCVEDLSHPVAEPSSSQAGSISNT 1 2 GSRPLSSGPASPKRKLEAAEEPPGEELSKRARVTEMPAQEPQTKDA* 0 >CRY2_spaJud Spalax judaei (blind_mole_rat) AJ606300 0 MAAASVVVATSAAPAMAVDGGSSVHWFRKGLRLHDNPSLLAAVRGARCVRCVYILDPWFAASSSVGINRWR 2 1 FLLQSLEDLDTSLRKLNSRLFVVRGQPADVFPRLFK 0 0 EWGVTRLTFEYDSEPFGKERDAAIMKMAKEAGVEVVTENSHTLYDLDR 2 1 IIDLNGQKPPLTYKRFQAIISRMELPKKPVVAVTSQQMESCRAEIQDNHDDTYGVPSLEEL 1 2 GFPTEGLGPAVWQGGETEALARLDKHLERK 0 0 AWVANYERPRMNANSLLASPTGLSPYLRFGCLSCRLFYYRLWDLYKK 1 0 VKRNSTPPLSLFGQLLWREFFYTAATNNPRFDRMEGNPICIQIPWDRNPEALAKWAEGKTGFPWIDAIMTQLRQEGWIHHLARHAVACFPTRGDLWVSWESGVR 0 0 VFDELLLDADFSVNAGSWMWLSCSAFFQQFFHCYCPVGFGRRTDPSGDYIR 2 2 RYLPKLKGFPSRYIYEPWNAPESIQKAARCIIGVDYPRPMVNHAETSRLNIERMKQIYQQLSRYRGL 1 2 CLLASVPSCVEDLSHPVAEPSSSQPGSITNT 1 2 GPRPLSTGPASPKRKLEAAEEPPGEELSKRARVTELPAPEPASKDA* 0 >CRY2_dipOrd Dipodomys ordii (kangaroo_rat) 0 MAAAMVTAAVAVPAPPSGADGASSVHWFRKGLRLHDNPALLAAVRGARCVRCVYILDPWFAASSSVGINRWR 2 1 FLLQSLEDLDTSLRKLNSRLFVVRGQPADVFPRLFK 0 0 EWGVTRLTFEYDSEPFGKERDAAIMKMAKEAGVEVVTENSHTLYDLDR 2 1 IIELNGQKPPLTYKRFQAIISRMELPKKPVGSVTSQQMESCRAEIQENHDDTYGVPSLEEL 1 2 GFPTEGLGPAVWQGGETEALARLDKHLERK 0 0 AWVANYERPRMNANSLLASPTGLSPYLRFGCLSCRLFYYRLWDLYKK 0 0 VKRNSTPPLSLFGQLLWREFFYTAATNNPRFDRMEGNPICIQIPWDRNPEALAKWAEGKTGFPWIDAIMTQL-QEGWIHHLARHAVTCFLTRGDLWVSW----- 0 --------------------------------------------------- 2 2 RYLPRLKGFPSRYIYEPWNAPESIQKAAKCIIGVDYPRPIVNHAETSRLNIERMKQIYQQLSRYRGL 1 2 CLLASVPSCVEDLSHPVAEPSSSQAGSISST 1 2 GPRPLSSGPASPKRKLEAAEEPPGEELSKRARVTEMPAQEPPSKDS* 0 >CRY2_cavPor Cavia porcellus (guinea_pig) 0 MAAAVGTGTAAAPTPVTGAEGACSVHWFRKGLRLHDNPALLAAVRGARCVRCVYILDPWFAASSSVGINRWR 2 1 FLLQSLEDLDTSLRKLNSRLFVVRGQPADVFPRLFK 0 0 EWGVTRLTFEYDSEPFGKERDAAIMKMAKEAGVEVVTENSHTLYDLDR 2 1 IIELNGQKPPLTYKRFQAIISRMELPKKPVGAVSSQQMESCRAEIQENHDDTYGVPSLEEL 1 2 GFPTEGLGPAVWQGGETEALARLDKHLERK 0 0 AWVANYERPRMNANSLLASPTGLSPYLRFGCLSCRLFYYRLWDLYKK 0 0 VKRNSTPPLSLFGQLLWREFFYTAATNNPRFDRMEGNPICIQIPWDRNPEALAKWAEGKTGFPWIDAIMTQLRQEGWIHHLARHAVACFLTRGDLWVSWESGVR 0 0 VFDELLLDADFSVNAGSWMWLSCSAFFQQFFHCYCPVGFGRRTDPSGDYIR 2 2 RYLPKLKGFPSRYIYEPWNAPESIQKAAKCIIGVDYPRPIVNHAETSRLNIERMKQIYQQLSRYRGL 1 2 CLLASVPSCVEDLSHPVAEPSLSQAGSSTST 1 2 GPRPLPGGPASPKRKLEAAEEPPGEELSKRARVAELPTPEPPSKDA* 0 >CRY2_hetGla Heterocephalus glaber (blind_mole_rat) EHA99865 0 MAAAVGTGTGAAPTPATGAEGACSVHWFRKGLRLHDNPALLAAVRGARCVRCVYILDPWFAASSSVGINRW 2 1 RFLLQSLEDLDTSLRKLNSRLFVVRGQPADVFPRLFK 0 0 EWGVTRLTFEYDSEPFGKERDAAIMKMAKEAGVEVVTENSHTLYDLDR 2 1 IIELNGQKPPLTYKRFQAIISRMELPKKPVGAVSSQQMKSCRAEIQENHDDTYGVPSLEEL 1 2 GFPTEGLGPAVWQGGETEALARLDKHLERK 0 0 AWVANYERPRMNANSLLASPTGLSPYLRFGCLSCRLFYYRLWDLYKK 0 0 VKRNSTPPLSLFGQLLWREFFYTAATNNPRFDRMEGNPICIQIPWDRNPEALAKWAEGKTGFPWIDAIMTQLRQEGWIHHLARHAVACFLTRGDLWVSWESGVR 0 0 VFDELLLDADFSVNAGSWMWLSCSAFFQQFFHCYCPVGFGRRTDPSGDYIR 2 1 RYLPKLKGFPSRYIYEPWNAPESVQKAAKCIIGVDYPRPIVNHAETSRLNIERMKQIYQQLSRYRGL 2 CLLASVPSCVEDLSHPVAEPTLSQAGSSSSTG 1 2 PRSLPDGPASPKRKLEAAEEPPGEELSKRARVAELPAPEPTSKDA* 0 >CRY2_speTri Spermophilus tridecemlineatus (squirrel) 0 MSASVVTTSATLLTP-TSADV-SSVHWFRKGLRL-DNPALLAAVRGARCVRCVYILDPWFAASSSVGINRWR 2 1 FLLQSLEDLDTSLRKLNSRLFVVRGQPADVFPRLFK 0 0 EWGVTRLTFEYDSEPFGKERDAAIMKMAKEAGVEVVTENSHT------ 2 1 IIELNGQKPPLTYKRFQAIISRMELPKKPVGAVSSQQMESCKAEIQEDHDDTYGVPSLEEL 1 2 GFPTEGLGPAVWQGGETEALARLDKHLERK 0 0 AWVANYERPRMNANSLLASPTGLSPYLRFGCLSCRLFYYRLWDLYKK 0 0 VKKNSTPPLSLFGQLLWREFFYTAATNNPRFDRMEGNPICIQIPWDRNPEALAKWAEGKTGFPWIDAIMTQLRQEGWIHHLARHAVACFLTRGDLWVSWESGVR 0 0 VFDELLLDADFSVNAGSWMWLSCSAFFQQFFHCYCPVGFGRRTDPSGDYIR 2 2 RYLPKLKGFPSRYIYEPWNAPESIQKAAKCIIGVDYPRPIVNHAETSRLNIERMKQIYQQLSRYRGL 1 2 CLLASVPSCVEDLSHPVAEPGSSQAGSISST 1 2 GPRPLSSGQASPKRKLEAAEEPPGEELSKRARVAELPTPELPSKDA* 0 >CRY2_oryCun Oryctolagus cuniculus (rabbit) 0 MAAAAAAAAAAVPAPAASANGASSVHWFRKGLRLHDNPALLAAVRGARCVRCVYILDPWFAASSSVGINRWR 2 1 FLLQSLEDLDTSLRKLNSRLFVVRGQPTDVFPRLFK 0 0 EWGVTRLTFEYDSEPFGKERDAAIMKMAKEAGVEVVTENSHTLYDLDR 2 1 IIELNGQKPPLTYKRFQAIISRMELPKKPAGSVTSQQLEGCRAEIQDNHDETYGVPSLEEL 1 2 GFPTEGLSPAVWQGGETEALARLDKHLERK 0 0 AWVANYERPRMNANSLLASPTGLSPYLRFGCLSCRLFYYRLWDLYKK 0 0 VKRNSTPPLSLFGQLLWREFFYTAATNNPRFDRMEGNPICIQIPWDRNPEALAKWAEGKTGFPWIDAIMTQLRQEGWIHHLARHAVACFLTRGDLWVSWESGVR 0 0 VFDELLLDADFSVNAGSWMWLSCSAFFQQFFHCYCPVGFGRRTDPSGDYVR 2 2 RYLPKLKGFPSRYIYEPWNAPESVQKAAKCIIGVDYPRPIVNHAETSRLNIERMKQIYQQLSRYRGL 1 2 CLLASVPSCVEDLSHPVAEPSSSQAGSVSGA 1 2 APRPLPSGPASPKRKLEAAEEPPGEELSKRARVAEVPTPELPSKAV* 0 >CRY2_ochPri Ochotona princeps (pika) 0 MMAATAA--AAVPAAAA---GASSVHWFRKGLRLHDNPALLAAVRGARCVRCVYILDPWFAASSSVGINRW- 2 2 ------------------------------------ 0 0 EWGVTRLTFEYDSEPFGKERDAAIMKMAREAGVEVVTENSHTLYDLDR 2 1 IIELNGQKPPLTYKRFQAIISRMELPRKPVGSVTSEQMESCRAEIQDNHDESYGVPSLEEL 1 1 ------------------------------ 0 0 ----------MNANSLLASPTGLSPYLRFGCLSCRLFYYRLWDLYKK 0 0 VKKNSSPPLSLYGQLLWREFFYTAATNNPRFDKMEGNPICVQIPWDKNPEALAKWAEGRTGFPWIDAIMTQLRQEGWIHHLARHAVACFLTRGDLWISWEEGMK 0 ---------DFSVNAGSWMWLSCSAFFQQFFHCYCPVGFGRRTDPSGDYIR 2 2 RYLPKLKGFPSRYIYEPWNAPESVQKAAKCIIGIDYPRPIVNHAETSRLNIERMKQIYQQLSRYRGL 1 2 CLLASVPSCVEDLSHPVAEPSSSQAGNVSST 1 2 GPRPLSSGPASPKRKLEAAEEPPGEELSKRARVAVVPAPELPSKAV* 0 >CRY2_vicPac Vicugna paca (vicugna) 0 MATAVATAAAAAPAPAAGAEGATSVHWFRKGLRLHDNPALLAAVRGAHCVRCVYILDPWFAASSSVGINRWR 2 1 FLLQSLEDLDTSLRKLNSRLFVVRGQPADVFPRLFK 0 0 EWGVTRLTFEYDSEPFGKERDAAIMKMAKEAGVEVVTENSHTLYDLDR 2 1 IIELNGQKPPLTYKRFQAIISRMELPKKPVGSVTSQQMESCRAEIQENHDETFGVPSLEEL 1 1 ------------------------------ 0 0 ----------------------------------------------- 0 0 VKRNSTPPLSLFGQLLWREFFYTAATNNPRFDRMEGNPICIQIPWDRNPEALAKWAEGKTGFPWIDAIMTQLRQEGWIHHLARHAVACFLTRGDLWVSWESGVR 0 0 VFDELLLDADFSVNAGSWMWLSCSAFFQQFFHCYCPVGFGRRTDPSGDYIR 2 2 RYLPKLKGFPSRYIYEPWNAPESVQKAAKCIIGVDYPRPMVNHAETSRLNIERMKQIYQQLSRYRGL 1 2 CLLASVPSCVEDLSNPVAEPSSSQAGSMSSA 1 2 GPRPLPGGPASPKRKLEAAEEPPGEELSKRARVAELPSTELPGRDV* 0 >CRY2_turTru Tursiops truncatus (dolphin) 0 MAAAVATSAVAAPAPAARAEGASSVHWFRKGLRLHDNPALQAAVRGAHCVRCVYILDPWFAASSSVGINRWR 2 1 FLLQSLEDLDTSLRKLNSRLFVVRGQPADVFPRLFK 0 0 EWGVTRLTFEYDSEPFGKERDAAIMKMAKEAGVEVVTENSHTLYDLDK 2 1 IIELNGQKPPLTYKRFQAIISRMELPKKPVGSVTSQQMEGCRAEIQENHDETYGVPSLEEL 1 2 GFPTEGLGPAVWQGGETEALARLDKHLERK 0 0 AWVANYERPRMNANSLLASPTGLSPYLRFGCLSCRLFYYRLWDLYKK 0 0 VKRSSTPPLSLFGQLLWREFFYTAATNNPRFDRMEGNPICIQIPWDRNPEALAKWAEGKTGFPWIDAIMTQLRQEGWIHHLARHAVACFLTRGDLWVSWESGVR 0 0 VFDELLLDADFSVNAGSWMWLSCSAFFQQFFHCYCPVGFGRRTDPSGDYIR 2 2 RYLPKLKGFPSRYIYEPWNAPESIQKAAKCIIGVDYPRPIVNHAETSRLNIERMKQIYQQLSRYRGL 1 2 CLLASVPSCMEDLSNPVAEPSSSQAGGMSSA 1 2 GPRPLPSGPASPKRKLGAAEEPPGEELSKRARVAGLPPSELLSKDV* 0 >CRY2_bosTau Bos taurus (cow) EG706191 lens 0 MAAA----AAATQAPAARGDGASSVHWFRKGLRLHDNPALLAAVRGAHCVRCVYILDPWFAASSSVGINRWr 2 2 ------------------------------------ 0 0 EWGVTRLTFEYDSEPFGKERDTAIMKMAKEAGVEVVTENSHTLYDLDK 2 1 IIELNGQKPPLTYKRFQAIISRMELPRKPVGSVTSQQMEGCRAEIQESHDETYGVPSLEEL 1 2 GFPTEGLGPAVWQGGETEALARLDKHLERK 0 0 AWVANYERPRMNANSLLASPTGLSPYLRFGCLSCRLFYYRLWDLYKK 0 0 VKRNSTPPLSLFGQLLWREFFYTAATNNPRFDRMEGNPICIQIPWDRNPEALAKWAEGKTGFPWIDAIMTQLRQEGWIHHLARHAVACFLTRGDLWVSWESGVR 0 0 VFDELLLDADFSVNAGSWMWLSCSAFFQQFFHCYCPVGFGRRTDPSGDYIR 2 2 RYLPKLKGFPSRYIYEPWNAPESIQKAAKCVIGVDYPRPIVNHAEASRLNIERMKQVYQQLSRYRGL 1 2 CLLASVPSCVEDLSNPVAEPSSIQAGSSSSV 1 2 GPRPLPGGPASPKRKLEAAEEPPGGELSKRARVAESLPSELPSRGV* 0 >CRY2_susScr Sus scrofa (pig) XM_003122835 0 MAAAVATAAASSPAPAAGAEGASSVHWFRKGLRLHDNPALLAAVRGAHCVRCVYILDPWFAASSSVGINRWR 2 1 FLLQSLEDLDTSLRKLNSRLFVVRGQPADVFPALFQ 0 0 EWGVTRLTFEYDSEPFGKERDAAIMKMAKEAGVEVVTENSHTLYDLDK 2 1 IIELNGQKPPLTYKRFQALISRMELPKKPVGSVTSQQMESCRAEIQENHDETYGVPSLEEL 1 2 GFPTEGLGPAVWQGGETEALARLDKHLERK 0 0 AWVANYERPRMNANSLLASPTGLSPYLRFGCLSCRLFYYRLWDLYKK 0 0 VKRNSTPPLSLFGQLLWREFFYTAATNNPRFDRMEGNPICIQIPWDRNPEALAKWAEGKTGFPWIDAIMTQLRQEGWIHHLARHAVACFLTRGDLWVSWESGVR 0 0 VFDELLLDADFSVNAGSWMWLSCSAFFQQFFHCYCPVGFGRRTDPSGDYIR 2 2 RYLPKLKGFPSRYIYEPWNAPESVQKAAKCIIGVDYPRPIVNHAETSRLNIERMKQIYQQLSRYRGL 1 2 CLLASVPSCVEDLSNPVAEPSSSQAGSVSAA 1 2 GPRPLPSGPASPKRKLEAAEEPPGEELSKRARVAELPPTELPGRDV* 0 >CRY2_equCab Equus caballus (horse) 0 ---------------------------------------------GGRGGCFLSLPGPGS-PPFWVGKKRGK 2 1 FLLQSLEDLDTSLRKLNSRLFVVRGQPADVFPRLFK 0 0 EWGVTRLTFEYDSEPFGKERDAAIMKMAKEAGVEVVTENSHTLYDLDR 2 1 IIELNGQKPPLTYKRFQAIISRMELPRKPVGSVTSQQMESCRADIQENHDETYGVPSLEEL 1 2 GFPTEGLGPAVWQGGETEALARLDKHLERK 0 0 AWVANYERPRMNAASLLASPTGLSPYLRFGCLSCRLFYYRLWDLYRK 0 0 VKRNSTPPLSLFGQLLWREFFYTAATNNPRFDRMEGNPICIQIPWDRNPEALAKWAEAKTGFPWIDAIMTQLRQEGWIHHLARHAVACFLTRGDLWVSWESGVR 0 0 VFDELLLDADFSVNAGSWMWLSCSAFFQQFFHCYCPVGFGRRTDPSGDYIR 2 2 RYLPKLKAFPSRYIYEPWNAPEAVQKAAKCIIGVDYPRPIVNHAETSRLNIERMKQIYQQLSRYRGL 1 2 CLLASVPSCVEDLSNPVAEPSSSQAGSVSSA 1 2 GPRPPPSGPASPKRKLEAAEEPPGEELSKRARV------EPPSRAV * 0 >CRY2_felCat Felis catus (cat) 0 ----------AAPAPAAGADGASSVHWFRKGLRLHDNPALLAAVRGARCVRCVYILDPWFAASSSVGINRWR 2 1 FLLQSLEDLDTSLRKLNSRLFVVRGQPADVFPRLFK 0 0 EWGVTRLTFEYDSEPFGKERDAAIMKMAKEAGVEVVTENSHTLYDLDR 2 1 IIDLNGQKPPLTYKRFQAIISRMELPKKPVGSVTSQQMESCRAEIQENHDEAYGVPSLEEL 1 2 GFPTEGLGPAVWQGGETEALARLDKHLERK 0 0 ----------------------------------------------- 0 0 VKRNSTPPLSLFGQLLWREFFYTAATNNPRFDRMEGNPICIQIPWDRNPEALAKWAEGKTGFPWIDAIMTQLRQEGWIHHLARHAVACFLTRGDLWVSWESGVR 0 0 VFDELLLDADFSVNAGSWMWLSCSAFFQQFFHCYCPVGFGRRTDPSGDYIR 2 2 RYLPMLKGFPSRYIYEPWNAPESIQKAAKCIIGVDYPRPIVNHAETSRLNIERMKQIYQQLSRYRGL 1 2 CLLASVPSCVEDLSNPVAEPSSSQTGNVSSA 1 2 ----------------------------------------------- * 0 >CRY2_canFam Canis familiaris (dog) 0 MAAAVVAAAAAAPVPTAGVDGASSVHWFRKGLRLHDNPALLAAVRGARCVRCVYILDPWFAASSSVGINRWR 2 1 FLLQSLEDLDTSLRKLNSRLFVVRGQPADVFPRLFK 0 0 EWGVTRLTFEYDSEPFGKERDAAIMKMAKEAGVEVVTENSHTLYDLDK 2 1 IIELNGQKPPLTYKRFQAIISRMELPKKPVGSVTSQQMESCRADIQDNHDDTYGVPSLEEL 1 2 GFPTEGLGPAVWQGGETEALARLDKHLERK 0 0 AWVANYERPRMNANSLLASPTGLSPYLRFGCLSCRLFYYRLWDLYKK 0 0 VKRNSTPPLSLFGQLLWREFFYTAATNNPRFDRMEGNPICIQIPWDRNPEALAKWAEGKTGFPWIDAIMTQLRQEGWIHHLARHAVACFLTRGDLWVSWESGVR 0 0 VFDELLLDADFSVNAGSWMWLSCSAFFQQFFHCYCPVGFGRRTDPSGDYIR 2 2 RYLPILKGFPSRYIYEPWNAPESIQKAAKCIIGVDYPRPIVNHAETSRLNIERMKQIYQQLSRYRGL 1 2 CLLASVPSCVEDLSNPVAEPSSSQTGSMSSA 1 2 GPRPLPSGPASPKRKLEAAEEPPGEELSKRARVAELPTPELPCRDV* 0 >CRY2_ailMel Ailuropoda melanoleuca (panda) XM_002922310 0 PAPAAGVDGASSVHWFRKGLRLHDNPALLAAVRGARCVRCVYILDPWFAASSSVGINRWR 2 1 FLLQSLEDLDTSLRKLNSRLFVVRGQPTDVFPRLFK 0 0 EWGVTRLTFEYDSEPFGKERDAAIMKMAKEAGVEVVTENSHTLYDLDK 2 1 IIELNGQKPPLTYKRFQAIISRMELPKKPVGSVTSQQMESCRADIQESHDDTYGVPSLEEL 1 2 GFPTEGLGPAVWQGGETEALARLDKHLERK 0 0 AWVANYERPRMNANSLLASPTGLSPYLRFGCLSCRLFYYRLWDLYKK 0 0 VKRNSTPPLSLFGQLLWREFFYTAATNNPRFDRMEGNPICIQIPWDRNPEALAKWAEGKTGFPWIDAIMTQLRQEGWIHHLARHAVACFLTRGDLWVSWESGVR 0 0 VFDELLLDADFSVNAGSWMWLSCSAFFQQFFHCYCPVGFGRRTDPSGDYIR 2 2 RYLPILKGFPSRYIYEPWNAPESIQKAAKCIIGVDYPRPIVNHAETSRLNIERMKQIYQQLSRYRGL 1 2 CLLASVPSCVEDLSNPVAEPSSSQTGSMSSA 1 2 GPRPLPSGPASPKRKLEAAEEPPGEELSKRARVAELPAPEPPSRDV* 0 >CRY2_myoLuc Myotis lucifugus (microbat) 0 MAANAVTAAAAAPAPAAGTDGASSVYWFRKGLRLHDNPALLAAVRGARCVLCVYILDPWFAASSSVGINRWR 2 1 FLLQSLEDLDTSLRKLNSRLFVVRGQPADVFPRLFK 0 0 EWGVTRLTFEYDSEPFGKERDAAIMKMAKEAGVEVVTENSHTLYDLDR 2 1 IIELNGQKPPLTYKRFQAIISRMELPKKPVASVTRHQMESCPAEIQENHDETYGVPSLEEL 1 2 GFPTEGLGPAVWQGGETEALARLDKHLERK 0 0 AWVANYERPRMNANSLLASPTGLSPYLRFGCLSCRLFYYRLWDLYKK 0 0 VKRNSSPPLSLFGQLLWREFFYTAATNNPRFDRMEGNPICIQIPWDRNPEALAKWAEGKTGFPWIDAIMTQLRQEGWIHHLARHAVACFLTRGDLWVSWESGFR 0 VFDELLLDADFSVNAGSWMWLSCSAFFQQFFHCYCPVGFGRRTDPSGDYIR 2 2 RYLPKLKGFPSRYIYEPWNAPESIQKAAKCIIGVDYPRPIVNHAETSRLNIERMKQIYQQLSRYRGL 1 2 CLLASVPSCMEDLSNPVAEPSLSQTGSMSSA 1 2 GPKPLPSGPASPKRKLEAAEEPPGEELSKRARVAELPATELPSRDV* 0 >CRY2_pteVam Pteropus vampyrus (macrobat) 0 MAATVGTAAAAASAPAAGTDGASSVHWFRKGLRLHDNPALLAAVRGARCVRCVYILDPWFAASSSVGINRWR 2 1 FLLQSLEDLDTSLRKLNSRLFVVRGQPTDVFPRLFK 0 0 EWGVTRLTFEYDSEPFGKERDAAIMKMAKEAGVEVVTENSHTLYDLDR 2 1 IIELNGQKPPLTYKRFQAIISRMELPKKPVGSVTSQHMESCTAEIQENHDETYGVPSLEEL 1 2 GFPTEGLGPAVWQGGETEALARLDKHLERK 0 0 AWVANYERPRMNANSLLASPTGLSPYLRFGCLSCRLFYYRLWDLYKK 0 0 VKRNSTPPLSLFGQLLWREFFYTAATNNPRFDRMEGNPICIQIPWDRNPEALAKWAEGKTGFPWIDAIMTQLRQEGWIHHLARHAVACFLTRGDLWVSWESGVR 0 0 VFDELLLDADFSVNAGSWMWLSCSAFFQQFFHCYCPVGFGRRTDPSGDYIR 2 2 RYLPKLKGFPSRYIYEPWNAPESIQKAAKCIIGVDYPRPIVNHAETSRLNIERMKQIYQQLSRYRGL 1 2 CLLASVPSCVEDLNNPVAEPSSSQTGSMNNA 1 2 GPRPLPSGPASPKRKLEAAEEPPGEELSKRARVAELPAPELPSRDV* 0 >CRY2_eriEur Erinaceus europaeus (hedgehog) 0 MAAVAVTAAAAAAGPGPVADGASSVHWFRKGLRLHDNPALLAAVRGARSVRCVYILDPWFAASSSVGINRW- 2 2 ------------------------------------ 0 0 EWGVTRLTFEYDSEPFGKERDTAIMKMAKEAGVEVVTENSHTLYDLDR 2 1 IIELNGQKPPLTYKRFQAIISRMELPRKPVGSVTSQQMESCRAEIQENHDETYGVPSLEEL 1 2 GFPTEGLGPAVWQGGETEALARLDKHLERK 0 0 AWVANYERPRMNANSLLASPTGLSPYLRFGCLSCRLFYYRLWDLYKK 0 0 VKRNSTPPLSLFGQLLWREFFYTAATNNPRFDRMEGNPICIQIPWDRNPEALAKWAEGKTGFPWIDAIMTQLRQEGWIHHLARHAVACFLTRGDLWVSWESGVR 0 0 VFDELLLDADFSVNAGSWMWLSCSAFFQQFFHCYCPVGFGRRTDPSGDYIR 2 2 RYLPKLKGFPSRYIYEPWNAPESVQKAAKCIIGVDYPRPIVNHAETSRLNIERMKQIYQQLSRYRGL 1 2 CLLASVPSCVEDLSNPMAEPSSSQAGSASSA 1 2 GPRSLTSGPASPKRKPKTAEEPP------------------------ * 0 >CRY2_sorAra Sorex araneus (shrew) 0 MATAAAAAAAAAPAPAARAEGACSVHWFRKGLRLHDNPALLAAVRGARCVRCVYILDPWFAASSSVGINRWR 2 1 FLLQSLEDLDTSLRKLNSRLFVVRGQPADVFPRLFK 0 0 ------------------------------------------------ 2 1 IIELNGQKPPLTYKRFQAIIGRMELPMKPVGSVSRQQMESCRAEIQENHDETYGVPSLEGL 1 2 GFPTEGLGPAVWQGGETEALARLDKHLERK 0 0 ----------------------------------------------- 0 0 VKRSHTPPLSLFGKLPWRE-LYTSATNHPRSDRM-ENPICIPDPWDRNPEALAKWAEGKTGFPWIDAIMTQLRQEGWIHHLARHAVACFLTRGDLWVSWESGVR 0 0 VFDELLLDADFSVNAGSWMWLSCSAFFQQFFHCYCPVGFGRRTDPSGDYIR 2 2 RYLPKLKGFPSRYIYEPWNAPEAVQKAAKCVIGVDYPRPMVNHAETNRLTIERMKQIYQKLSSYWGH 1 2 CLLASVPSCVEELSNPMAEPSGSQAG--SSA 1 2 ----------------------------------------------- * 0 >CRY2_loxAfr Loxodonta africana (elephant) 0 MAAAVVTAGAAALVPIPSMDGASSVHWFRKGLRLHDNPALLAAVRGARCVRCVYILDPWFAASSSVGINRWR 2 1 FLLQSLEDLDTSLRKLNSRLFVVRGQPADVFPRLFK 0 0 EWGVTRLTFEYDSEPFGKERDAAIMKMAKEAGVEVVTENSHTLYDLDR 2 1 IIELNGQKPPLTYKRFQAIISRMELPKKPVGSVTSQQMESCRAEIQENHDETYGVPSLEEL 1 2 GFPTEGLGPAVWQGGETEALARLDKHLERK 0 0 AWVANYERPRMNANSLLASPTGLSPYLRFGCLSCRLFYYRLWELYKK 0 0 VKRNSTPPLSLFGQLLWREFFYTAATNNPRFDRMEGNPICIQIPWDRNPEALAKWAEGKTGFPWIDAIMTQLRQEGWIHHLARHAVACFLTRGDLWVSWESGVR 0 0 VFDELLLDADFSVNAGSWMWLSCSAFFQQFFHCYCPVGFGRRTDPSGDYIR 2 2 RYLPKLKGFPSRYIYEPWNAPESIQKAAKCIIGVDYPRPIVNHAETSRLNIERMKQIYQQLSRYRGL 1 2 CLLASVPSCVEDLSSPVAEPSSSQAGSSNSA 1 2 GPRPLPSGPTSPKRKLEAAEEPPGEELSKRARVAKLPGPELPSKDV * 0 >CRY2_proCap Procavia capensis (hyrax) 0 MAATAATAVAAALAPAPTADGVSSVHWFRKGLRLHDNPALLAAVRGARCVRCVYILDPWFAASSSVGINRWR 2 1 FLLQSLEDLDTSLRKLNSRLFVVRGQPADVFPRLFK 0 0 -----------------------------EAG-RVVTENSHTLYDLDR 2 1 IIELNGQKPPLTYKRFQAIVSRMELPRKPVGSVTSQQMESCRAEMQENHEEIYGVPSLEEL 1 2 GFPTEGLGPAVWQGGETEALARLDKHLERK 0 0 ----------------------------------------------- 0 0 VKRNSTPPLSLFGQLLWREFFYTAATNNPRFDRMEGNPICIQIPWDRNPEALAKWAEGKTGFPWIDAIMTQLRQEGWIHHLARHAVACFLTRGDLWVSWESGVR 0 0 VFDELLLDADFSVNAGSWMWLSCSAFFQQFFHCYCPVGFGRRTDPSGDYIR 2 2 RYLPKLKGFPSRYIYEPWNAPESIQKAAKCIIGVDYPRPIVNHAETSRLNIERMKQIYQQLSRYRGL 1 2 CLLASVPSCVEDLSNPVAEPSSSPAGHMSSA 1 2 GLRPLPSGPASPKRKLEAAEEPPGEELSKRARVAKLPGPELPSTDA* 0 >CRY2_echTel Echinops telfairi (tenrec) 0 MAAAVGTAALAATAPAPNKDGASSVHWFRKGLRLHDNPALLAAVRGARCVRCVYILDPWFAASSSVGINRWR 2 1 FLLQSLADLDARLRTLHSRLFVVRGQPADVFPRLFK 0 0 EWGVTRLTFEYDSEPFGKERDAAIMKLAKEAGVEVVTENSHTLYDLDR 2 1 IIELNGQKPPLTYKRFQAIISRMELPRKPAGAPTGLQMESCQAEIPENHAETYGVPSLEEL 1 2 GFPTEGLGPAVWQGGETEALARLDKHLERK 0 0 AWVASYERPRMNANSLLASPTGLSPYLRFGCLSCRLFYYRLWDLYKK 0 0 VKRNSTPPLSLFGQLLWREFFYTAATTNPRFDRMEGNPICIQIPWDRNPEALAKWAEGKTGFPWIDAIMTQLRQEGWIHHLARHAVACFLTRGDLWVSWESGVR 0 0 VFDELLLDADFSVNAGSWMWLSCSAFFQQFFHCYCPVGFGRRTDPSGDYI- 2 2 ------------------------------------------------------------------- 1 1 ------------------------------- 1 2 -----------------------------------------------* 0 >CRY2_choHof Choloepus hoffmanni (sloth) 0 MAATAVMAGSAAPAPASGTEGASSVHWFRKGL*LHDNPALLAAVRGARCVRCVYILDPWFAASSSVGINRWR 2 1 FLLQSLEDLDTSLRKLNSRLFVVRGQPADVFPRLFK 0 0 EWGVTRLTFEYDSEPFGKERDAAIMKMAKEAGVEVVTENSHTLYDLDR 2 1 IIELNGQKPPLTYKRFQAIISRMELPKKPVGSVTSQQMESCRAEIQENHDETYGVP----- 1 1 -FPTEGLGPAVWQGGEAEALARLDKHLERK 0 0 AWVANFERPQMNANSLLASPTGLSPYLQFGCLSCQLFYFKLTDLYKK 0 0 VKRNSTPPLSLFGQLLWREFFYTAATNNPRFDRMEGNPICIQIPWDRNPEALAKWAEGKTGFPWIDAIMTQLRQEGWIHHLARHAVACFLTRGDLWVSWESGVR 0 0 VFDELLLDADFSVNSGSWMWLSCSAFFQQFFHCYCPVGFGRRTDPSGDYIR 2 2 RYLPKLKGFPSRYIYEPWNAPESIQKAAKCIIGVDYPRPIVNHAETSRLNIERMKQIYQQLSRYRGL 1 2 CLLASVPSCVEDLSNPVAEPSSSQAGSMSSA 1 2 GPRPVPSGPASPKRKLEAAEEPPGEELSKRARVTELPTPELPSKDV* 0 >CRY2_macEug Macropus eugenii (wallaby) FY652314 testis 0 ------------------------------------------------------------------------ 2 1 FLLQSLEDLDISLRKLNSRLFVVRGQPTDVFPRLFK 0 0 EWGVTRLTFEYDSEPFGKERDAAIVKMAKEAGVEVVTENSHTLYDLDR 2 1 IIELNGQKPPLTYKRFQAIISRMELPKKPVSCVTSQQMEQCQAEIQENHDDTYGVPSLEEL 1 2 GFPTDGLGPAVWQGGEMEALARLDKHLERK 0 0 AWVANYERPRMNATSLLASPTGLSPYLRFGCLSCRLFYYRLWELYKK 0 0 VKRNNTPPLSLYGQLLWREFFYTAATNNPKFDRMEGNPICIQIPWDRNPEALAKWAEGKTGFPWIDAIMTQLRQEGWIHHLARHAVACFLTRGDLWVSWESGVR 0 0 VFDELLLDADFSVNAGSWMWLSCSAFFQQFFHCYCPVGFGRRTDPSGDYVR 2 2 RYLPQLKGFPSRYIYEPWNAPESVQKAAKCIIGVDYPKPIVNHAETSRLNIERMKQIYQQLSRYRGL 1 2 CLLASVPSCMEDLSSPMAETSMGQAGSVSST 1 2 GPKPLPCSPASPKRK LEATEEASREEHSKRARMAALPVPELAS----* 0 >CRY2_monDom Monodelphis domestica (opossum) 0 MAAAVVTMTAAAPAPAPSPEGASSVHWFRKGLRLHDNPALQAALRGARCVRCVYILDPWFAASSSVGINRWR 2 1 FLLQSLEDLDISLRKLNSRLFVVRGQPTDVFPRLFK 0 0 EWGVTRLTFEYDSEPFGKERDAAIVKMAKEAGVEVVTENSHTLYDLDR 2 1 IIELNGQKPPLTYKRFQAIISRMELPRKPVNSVTSQQMERCQAEIQENHDDAYGVPSLEEL 1 2 GFPTDGLGPAVWQGGETEALARLDKHLERK 0 0 AWVANYERPRMNAASLLASPTGLSPYLRFGCLSCRLFYYRLWELYKK 0 0 VKRNNTPPLSLYGQLLWREFFYTAATNNPKFDRMEGNPICIQIPWDRNPEALAKWAEGKTGFPWIDAIMTQLRQEGWIHHLARHAVACFLTRGDLWVSWESGVR 0 0 VFDELLLDADFSVNSGSWMWLSCSAFFQQFFHCYCP-GFGRRTDPSGDYVR 2 2 RYLPQLKGFPARYIYEPWNAPEPVQKAAKCIIGVDYPRPIVNHAETSRLNIERMKQIYQQLSRYRGL 1 2 CLLASVPSCLEDLSSPMVEASLGQAGAVSGP 1 2 GLKPLPCSPASPKRKLEATEEAPGEEHSKRARVARLPGSELAGKDV* 0 >CRY2_ornAna Ornithorhynchus anatinus (platypus) 0 ---------------------------------LHDNPALQAALRGARSVRCVYILDPWFAASSSVGINRWR 2 1 FLLQSLEDLDTSLRKLNSRLFVVRGQPTDVFPRLFK 0 0 EWGVTRLTFEYDSEPFGKERDAAIVKMAKEAGVEVVTENSHTLYDLDR 2 1 IIELNGQKPPLTYKRFQAIISRMELPKKPVSCVTSQQMEGCKAEIQDNHDDTYGVPSLEEL 1 2 GFPTDGLGPAVWQGGETEALARLDKHLERK 0 0 AWVANYERPRMNANSLLASPTGLSPYLRFGCLSCRLFYYRLWDLYKK 0 0 VKRNSTPPLSLYGQLLWREFFYTAATNNPRFDRMEGNPICIQIPWDRNPEALAKWAEGKTGFPWIDAIMTQLRQEGWIHHLARHAVACFLTRGDLWVSWESGVR 0 0 VFDELLLDADFSVNAGSWMWLSCSAFFQQFFHCYCPVGFGRRTDPSGDFIR 2 2 RYLPKLKAFPSRYIYEPWNAPESVQKAAKCVIGVDYPRPIVNHAETSRLNIERMKQIYQQLSRYRGL 1 2 CLLASVPSCVEDLSSAAAESGLGQASGSNIST 1 2 APRPPPPPYGPASPKRKLEAAEGLPGEELCKRPKVAGRPGPEPPGEDA* 0 >CRY2_galGal Gallus gallus (chicken) AJ396745 bursa 19456395 15459395 0 MAAAASPPRGFCRSVHWFRRGLRLHDNPALQAALRGAASLRCIYILDPWFAASSAVGINRWR 2 1 FLLQSLEDLDNSLRKLNSRLFVVRGQPTDVFPRLFK 0 0 EWGVTRLTFEYDSEPFGKERDAAIIKLAKEAGVEVVIENSHTLYDLDR 2 1 IIELNGNKPPLTYKRFQAIISRMELPKKPVSSIVSQQMETCKVDIQENHDDVYGVPSLEEL 1 2 GFPTDGLAPAVWQGGETEALARLDKHLERK 0 0 AWVANYERPRMNANSLLASPTGLSPYLRFGCLSCRLFYYRLWELYKK 0 0 VKRNSTPPLSLYGQLLWREFFYTAATNNPKFDRMEGNPICIQIPWDKNPEALAKWAEGKTGFPWIDAIMTQLRQEGWIHHLARHAVACFLTRGDLWISWESGVR 0 0 VFDELLLDADFSVNAGSWMWLSCSAFFQQFFHCYCPVGFGRRTDPSGDYVK 2 2 RYLPKLKGFPSRYIYEPWNAPESVQKAAKCIIGVDYPKPMVNHAETSRLNIERMKQIYQQLSRYRGL 1 2 CLLASVPSCVEDLSGPVTDSAPGQGSSTST 1 2 AVRLPQSDQASPKRKHEGAEELCTEELYKRAKVTGLPAPEIPGKSS* 0 >CRY2_taeGut Taeniopygia guttata (finch) FE716439 brain 0 --------------------------------------------IYILDPWFAATSAVGINRWR 2 1 FLLQSLEDLDNSLRKLNSRLFVVRGQPTDVFPRLFK 0 0 EWGVTRLTFEYDSEPFGKERDAAIVKLAKEAGVEVVIENSHTLYDLDR 2 1 IIELNGHKPPLTYKRFQAIISRMELPKKPVSTVISQQMETCKVDIQENHDDVYGVPSLEEL 1 2 GFPTDGLAPAVWQGGETEALARLDKHLERK 0 0 AWVANYERPRMNANSLLASPTGLSPYLRFGCLSCRLFYYRLWELYKK 0 0 VKRNSTPPLSLYGQLLWREFFYTAATNNPKFDRMEGNPICIQIPWDRNPEALAKWAEGKTGFPWIDAIMTQLRQEGWIHHLARHAVACFLTRGDLWISWESGVR 0 0 VFDELLLDADFSVNAGSWMWLSCSAFFQQFFHCYCPVGFGRRTDPSGDYVK 2 2 RYLPKLKGFPSRYIYEPWNAPESVQKAAKCIIGVDYPKPMVNHAETSRLNIERMKQIYQQLSRYRGL 1 2 CLLASVPSCVEDISGPVPDSASGQGCSTST 1 2 AVRLSQAEQASPKRKHEGAEEPCSEELYKRAKVTGLPTSEISGKSL* 0 >CRY2_allMis Alligator mississippiensis (alligator) genome/blat 0 MAASRSFPSSVPARAGPCRAVHWFRRGLRMHDNPALQAALRDAASVRCIYILDPWFAASSAVGINRWR 2 1 FLLQSLEDLDNSLRKLNSRLFVVRGQPTDVFPRLFK 0 0 EWGVTRLTFEYDSEPFGKERDAAIIKLAKEAGVEVVIENSHTLYDLDR 2 1 IIELNGNKPPLTYKRFQAIISRMELPKKPVSSITSQQMEKCKAEIQENHDDVYGVPSLEEL 1 2 GFPMDGLAAAVWQGGEMEALARLDKHLERK 0 0 AWVANYERPRMNANSLLASPTGLSPYLRFGCLSCRLFYYRLWELYKK 0 0 VKRNSTPPLSLYGQLLWREFFYTAATNNPKFDRMEGNPICIQIPWDRNPEALAKWAEGKTGFPWIDAIMTQLRQEGWIHHLARHAVACFLTRGDLWISWECGVR 0 0 VFDELLLDADFSVNAGSWMWLSCSAFFQQFFHCYCPVGFGRRTDPSGDYVK 2 2 RYLPKLKGFPSRYIYEPWNAPESVQKAAKCIIGVDYPKPMVNHAETSRLNIERMKQIYQQLSRYRGL 1 2 GLLASVPSCAEDLSGPVTDPASVQGCSTST 1 2 ALKPSQSGQASPKRKHEGIEEMCTEDLYKRAKVTGLHGPEIPSKSL* 0 >CRY2_anoCar Anolis carolinensis (lizard) XM_003214641 0 MAALPGPLGRCSVHWFRRGLRLHDNPALQAAIRDGGPVRCIYILDPWFAASSSVGINRWR 2 1 FLLQSLEDLDNSLRKLGSRLFVVRGQPTDVFPRLFK 0 0 EWRVTRLTFEYDSEPFGKERDAAIVKLAKEAGVEVITENSHTLYDLDR 2 1 IIELNGHKPPLTYKRFQTIISRMDLPKKPVASITHQQMEMCKTEIQDNHDETYGVPSLEEL 1 2 GFPTESLAPAVWLGGETEALTRLDKHLERK 0 0 AWVANYERPRMNANSLLASPTGLSPYLRFGCLSCRLFYYRLWELYKK 0 0 VKRNSTPPLSLYGQLLWREFFYTAATNNPKFDRMEGNPICIQIPWDRNPEALAKWAEGKTGFPWIDAIMTQLRQEGWIHHLARHAVACFLTRGDLWISWESGVR 0 0 VFDELLLDADFSVNSGSWMWLSCSAFFQQFFHCYCPVGFGRRTDPSGDYVR 2 2 RYLPKLKGFPSRYIYEPWNAPESVQKAAKCIIGVDYPKPMVNHAETSRLNIERMKQIYQQLSRYRGL 1 2 CLLASVPSCMEDLSNPVADTSSSHGNCIGT 1 2 ASRQTHCGQTSPKRKHDVVQEYKEELYKRAKVVASQFAENPRQELVHHEMGN* 0 >CRY2_xenTro Xenopus tropicalis (frog) NM_001088670 AY049035 CX389867 11533577 discrepancies 0 MEGKPSVSSVHWFRKGLRLHDNPALLSALRGANSVRCVYILDPWFAASSSGGVNRWR 2 1 FLLQSLEDLDTSLRKLNSRLFVVRGQPADVFPRLFK 0 0 EWGVSRLTFEYDSEPFGKERDAVIMKLAKEaGVEVVVENSHTLYDLDR 2 2 VIELNGHSPPLTYKRFQAIISRMELPRRPAPSVTRQQMEACRAEIKRNHDETYGVPSLEEL 1 1 GFHsEiKGpsIWPGGETEALARLDRHLERK 0 0 AWVANYERPRMNANSLLASPTGLSPYLRFGCLSCRLFYYRLKELYKK 0 0 VKKNSPPPLSLYGQLLWREFFYTAATNNPKFDQMEGNPICVQIPWDKNPKALAKWAEGKTGFPWIDAIMTQLRQEGWIHHLARHAVACFLTRGDLWNSWECGVK 0 0 VFDELLLDADFSVNAGSWMWLSCSAFFQQFFHCYCPVGFGRRTDPSGDYVR 2 2 RYLPVLKAFPSRYIYEPWSAPESVQKEAKCIIGIDYPKPIVNHAEASRMNIERMKQTYQQLSRYRGL 1 1 CILASVPSCMEDLGGPMADSSQNISE 1 2 AGKMAPPSHTSGESVLAAQYTAGI* 0 >CRY2_ranCat Rana catesbeiana (bullfrog) GO458565 AY256684 0 MEGPAVSSVHWFRKGLRLHDNPALLAALRGARCVRCVYILDPWFAASSSSSGGVNRWR 2 1 FLLQSLEDLDSSLRKLGSRLFVGRGQPADVFPRLFK 0 0 EWGVTRLTFQYYSEPFGKERDAAIMKLAKEAGVEVIVESSHTLYDLDK 2 2 IIELNGNSPPLTYKRFQAIVSRMELPRRPVPSITRQQMEKCRAEIKSTHDDTYGVPSLEEL 1 1 GFPRDNPGAAVWPGGETEALARLDRHLERK 0 0 AWVAHYERPRMNANSLLASPTGLSPYLRFGCLSCRLFYYRLRELYQKVKK 0 0 VKKNSPPPLSLFGQLLWREFFYTAATNNPKFDQMEGNPICVQIPWDKNPEALAKWTEGKTGFPWIDAIMTQLRQEGWIHHLARHAVACFLTRGDLWNSWECGVK 0 0 VFDELLLDADFSVNAGSWMWLSCSAFFQQFFHCYCPVGFGRRTDPSGDYVR 2 2 RYLPVLKGYPSRYIYEPWNAPESVQKEAKCIVGVDYPKPVVNHAEASRLNIERMKQTYQQLSRYRGL 1 1 CILASVPSSVEDLSGPMADPASSQQGSS 1 2 DPAPRLCAVDSPKRKHEDLDGELCKKARLQCVQEMERAAKDFL* 0
Cryptochrome CRY4 sequences
(more shortly)
>CRY4_galGal Gallus gallus (chicken) NP_001034685 CRY4 PumMed:19663499 synteny: ADIPOR1 UBE2T CRY4 LRIF1 DRAM2 CEPT1 0 MRHRTIHLFRKGLRLHDNPALLAALQSSEVVYPVYILDRAFMTSSMHIGALRWHFLLQSLEDLRSSLRQLGSCLLVIQGEYESVVRDHVQKWNITQVTLDAEMEPFYKEMEANIRGLGEELGFQVLSLMGHSLYNTQR 2 1 ILELNGGTPPLTYKRFLRILSLLGDPEVPVRNPTAEDFQ 2 1 RCSPPELGLAECYGVPLPTDLKIPPESISPWRGGESEGLQRLEQHLADQ 0 0 GWVASFTKPKTVPNSLLPSTTGLSPYFSTGCLSVRSFFYRLSNIYAQ 0 0 AKHHSLPPVSLQGQLLWREFFYTVASATPNFTKMAGNPICLQIRWYEDAERLHKWKT 0 0 AQTGFPWIDAIMTQLRQEGWIHHLARHAAACFLTRGDLWISWEEGMK 0 0 VFEELLLDADYSINAGNWMWLSASAFFHHYTRIFCPVRFGRRTDPEGQYIR 2 1 KYLPILKNFPSKYIYEPWTASEEEQKQAGCII 1 2 GRDYPFPMVDHKEASDHNLQLMKQAREEQHRIAQLTR 1 2 DDADDPMEMKLKRDHSEESFTKTKAARMTEQT* 0 >CRY4_taeGut Taeniopygia guttata (finch) XM_002198497 0 MLHRTIHLFRKELRLHDNPVLLAALESSEALYPVYILDRAFLTSSMHIGALRWNFLLQSLEDLHKNLGQLGSCLLVIQGEYEIVLRDHIQKWNITQVTLDAEMEPFYKEMEANIQRLGAELGFEVLSLVSHSLYNTQR 2 1 ILDLNGGSPPLTYKRFLHILSLLGDPELPVRNLTAEDFQ 2 1 RCRAPEPGLAECYRVPLPVDLKISPESLSPWRGGETEGLRRLEQHLIDQ 0 0 GWVTSFAKPRTSPNSLLPSTTGLSPYFSMGCLSVRTFFYRLSNIYAQ 0 0 AKHHSLPPVSLQGQLLWREFFYTVASATPNFTQMAGNPICLQISWYKDAERLHKWKT 0 0 AKTGFPWIDAIMTQLRQEGWIHHLARHAVACFLTRGDLWISWEEGMK 0 0 VFEELLLDADYSINAGNWMWLSASAFFHQYTRIFCPVRFGKRTDPQGNYIR 2 1 KYLPILKNFPSKYIYEPWTASEEEQKLAGCII 1 2 GQDYPFPMVNHKEASDHNLQLMKQVREEQHRTVQLTR 1 2 DDADDPMEIRVKRDHSEENISKGKVARTTE* 0 >CRY4_melGal Meleagris gallopavo (turkey) XM_003212851 0 MRHRTIHLFRKGLRLHDNPALLAALQSSEVVYPVYILDRAFMTSSMHIGALRWHFLLQSLEDLRSSLCQLGSCLLVIQGEYDAVVRDHVQKWNITQVTLDAEMEPFYKEMEANIRALGEELGFEVLSLMGHSLYNTQR 2 1 ILELNGGTPPLTYKRFLHILSLLGDPEMPIRNLTAEDFQ 2 1 RCSPPELCLAECYRVPLPTDLKIPPESISPWRGGESEGLQRLEQHLADRS 0 0 GWVASFTKPKTVPNSLLPSTTGLSPYFSMGCLSVRSFFYRLSNIYAQ 0 0 AKHHSLPPVSLQGQLLWREFFYTVASATPNFTKMAGNPICLQIRWYEDAERLHRWKT 0 0 AQTGFPWIDAIMTQLRQEGWIHHLARHAAACFLTRGDLWISWEEGMK 0 0 VFEELLLDADYSINAGNWMWLSASAFFHHYTRIFCPVRFGRRTDPEGQYIR 2 1 KYLPILKNFPSKYIYEPWTASEEEQKQAGCII 1 2 GRDYPFPMVDHKEASDHNLQLMKQVREEQYRTAQLTR 1 2 DDADDPMEMKLKRDHSEENLTKTKAARMTKQT* 0 >CRY4_pasDom Passer domesticus (sparrow) AY494987 16687285 fragment 0 KGLRLHDNPVLLAALESSEALYPVYILDRAFLTSSMHIGALRWNFLLQSLEDLHKNLGQLGSCLLVIQGEYEIVLRDHIQKWNITQVTLDAEMEPFYKEMEANIQRLGVELGFEVFSLVSHSLYNTQR 2 1 ILDLNGGSPPLTYKRFLHILSLLGDPEVPVRNVTAEDFQ 2 1 RCRAPDPGLAECYRVPLPVDLKISPESLSPWRGGETEGLQRLERHLTDQ 0 0 GWVTSFTKPRTVPNSLLPSTTGLSPYFSMGCLSVRTFFYRLSNIYAQ 0 0 AKHHSLPPVSLQGQLLWREFFYTVASATPNFTQMAGNPICLQICWYKDAERLHKWKT 0 0 AQTGFPWIDAIMTQLRQEGWIHHLARHAVACFLTRGDLW 0 0 2 1 1 2 1 2 * 0 >CRY4_anoCar Anolis carolinensis (lizard) synteny: UBE2T CRY4 LRIF1 DRAM2 0 2 1 IVELNRGTPPLTYKRFLQILTTLGDPEMPVEDLTAENSQ 2 1 KLCPLPEEDLDECYRVPLPEDLGISKEHLSPWRGGETTGLQRLEEHMKNQV 0 0 GWIAKFTKPRTIPNSLLPSTTGLSPYFSLGCLSVRMFFYRLSKIYAQ 0 0 SKNHSLPPVSLQGQLLWREFFYTVASATPNFTKMVGNPICLQIEWYEDAEKLHKWKT 0 AQTGFPWIDAIMTQLRQEGWIHHLARHAVACFLTRGDLWISWEEGMK 0 0 VFEELLLDSDYSINAGNWMWLSASAFFHQYSRIFCPVRFGKRTDPEGHYIR 2 1 KYLPVLKNFPSKYIYEPWTAPAEAQREAGCII 1 2 GKEYPFPMVNHKEVSDNNLQLMKQVREEQYKTAQLTR 1 2 DDVDDPMEMGLKHRHSEEVTPKGKHARKAEEL* 0 >CRY4_xenTro Xenopus tropicalis (frog) NP_001123706 0 MPHRTIHIFRKGLRLHDNPTLVTALETSDVVYPVYILDRNFMTSSSVIGSKRWNFFLQSIEDLHCNLQKLNSCLFVIQGDYERVLREHVEKWNITQVTFDLEIEPYYKGLDERIRAMGQELGFEVVSMVAHTLYDIKK 1 ILALNCGKPPLTYKNFLRVLSMLGNPDKPARQITSEDFIK 2 1 CITPTKLAAEEYYRIPKPEDLGISKDCPTNWIGGESEALSRLEQHLEKQ 0 GWVANFKKPQTIPNSLLPSTTGLSPYFSLGCLSVRVFFHRLSNIYAQ 0 0 SKNHSLPPVSLQGQLLWREFFYTVASSTPNFTHMVGNPICLQIDWYKNEEQLQKWKE 0 0 AKTGFPWIDAIMTQLHNEGWIHHLARHAVACFLTRGDLWISWEEGMK 0 0 VFEEFLLDADYCINAGNWMWLSASAFFHHYTRIFCPVRFGKRSDPEGNYIR 2 1 KYLPVLKNFPAKYIYEPWTAPEEIQKQAGCLI 1 2 GKDYPLPMVDHKTASEHNLQLMRQVREEQQKTAQLTK 1 2 DIADDPMELNLKHPFKNDKECGLENNKVKRRCLEEMTAEDGTRQSDLVQSLDPCEVKVC* 0 >CRY4_braFlo Branchiostoma floridae (amphioxus) XM_002595028 64% CRY4_danRer MANKVQHSTIHWFRKGLRFHDNPSLLHALRTSRHVYPVYVVDQNWMKEHDIRYGANWWRFVIQCLEELDTRLRKYGLRLFVVRGSAEDFFKEHFRKWKVTQL THDVDTEPFYRIRDVAVRKIASDMGVEVVTHVAHTLYDIDRTVERNGGTPPLTYRKFLKVYNEMGKPPKEKETATTEHFANCTLPPEALQDKKFDMVTLEELGMRCDFPAKFVGGE TEALRRLEKSLEDKDWVLKFEKPKTSPNSLLPSTTVLSPYITVGCLSARLFYHQLDKIYSKAKNHSQPPVSLHGQLIWREFFYTAAAHTPNFNQMEGNRVCLQIPWNKNDEHLTRW RNAQTGFPWIDAAMTQLRKEGWIHHLARHAVACFLTRGDLWISWEEGMKVFEELLLDADWSLNAGNWMWLSASAFFHQYFRVYSPIVFGKKTDPKGTFIRHYLPVLKNFPKEYIYE PWKAPRNVQEKAGCIVGKDYPRPIVDHKEASQRNLDIMRDVRKDQKETASFQIWRTV* 0 >CRY4_nemVec Nematostella vectensis (sea_anemone) XP_001636303 MASKKTHQTVHWFRNGLRLHDNPALKEAFETSQTVRPLYVLDPDVLKNGNIGVVRWRFILESLADLDNNLKKLNSRLFVVRGRPSEVFPKLFKEWKISKL TFEVDTTEPARKQDAEVLKIANKLGVDIEQRVSHTLYDLDRIVNKNGGTAPLTYKKFQSIVSSLGPPAAPLPAIDKKMVAGCNTPTTANHDKIYGVPTLE EIGQEVPEESREVLYPGGETEALERLEVYMKKEDWVCKFEKPNTAPNSIEPSTTVLSPYMTYGCLSARLFYTRLAEIYAKKKKHSQPPVSLHGQLLWREF FTTAAYKTPNFNKMVGNSLCLQVPWDQNDEYLAAWAEARTGYPYIDAIMTQLRREGWVHHLARHSVACFLTRGDLWISWEEGLKVFERLLIDHDWNLNAG NWMWLSASSFFHAYFRVYSPVAFGKKTDPNGDYIRKYIPKLSRYPPKYIYEPWNAPLAVQEKAGCVIGRDYPCPIVDHNKVVTRNMSRMKEARSLKYGKT DMGVDKPEASFLCISLGWSSRGKDTSAMGRKFV* 0
DASH cryptochrome CRY3 sequences
DASH is yet another member of the cryptochrome and photolyase family. It was identified only recently as active only on ssDNA repair, reportedly because of a barrier to flipping the damaged cyclobutane pyrimidine dimer dinucleotide out of dsDNA into its active repair site unless it is in a loop. In the species investigated to date, this enzyme uses folate (MTHF) and FAD, activated by blue light.
Its name is a peculiar acronym of Drosophila, Arabidopsis, Synechocystis and Homo. The gene has been lost in Drosophila or Homo. In Arabidopsis, it is denoted CRY3. The many genome projects available today allow a quick determination of its very unusual phylogenetic distribution.
Although originally studied in plants and cyanobacteria, the DASH photolyase surprisingly extends into fish, frogs, salamanders, turtle, lizard, and birds (duck, finch and budgerigar but not chicken or turkey). It's not clear however if the protein function has stayed the same in all these taxa or drifted in new roles like CRY1 and CRY2 or has acquired multiple functions in single species.
Using blastx on the syntenic region in gallinaceaous birds (chicken and turkey) establishes that they have a fairly degenerate multi-exonic pseudogene at the expected location and orientation. It is not currently possible to date this more precisely nor determine whether pseudogenization occurred in a common ancestor or independently on account of domestication.
DASH is also missing from alligator and crocodile assemblies, the lobe-finned coelocanth assembly, and chondrichthyes genomes and transcripts. These probably represent additional, independent gene losses rather than just poor assemblies -- the overall conservation of DASH is much less stringent suggesting loosened constraints or even a measure of functional redundancy.
Platypus does not have any pseudogene debris at the expected location but the assembly has a break here. Marsupials and placentals again appear never to have had this enzyme as it had been lost in the earliest mammals.
The phylogenetic loss pattern of DASH parallels the [Opsin_evolution:_trichromatic_ancestral_mammal|massive loss of opsins] that also occured early in mammalian evolution -- which GT Walls in 1942 [attributed] to mammals experiencing a sustained period of deep nocturnality where these systems did not need to function (no UV damage) and indeed could not function (insufficient blue light even with antenna) and so were lost, implying they were not sustained by a Piatigorskyian secondary functionality such as circadian rhythm or magnetosensing.
The great oxygenation event gave rise to a stratospheric ozone protective layer at 2.4 gyr but reached an even higher lever during the early Cambrian (based indirectly on oxygen levels). This may have favored independent but simultaneous gene loss events in various clades.
However the first land plants and animals risked greatly increased levels of UV damage that may correlate with DASH retention. Here it must be clarified whether repairable damage can arise from direct oxidative damage in addition to ultraviolet light which could not plausibly be an issue for benthic marine organisms that still retain this enzyme.
The amniote proteins can easily be modeled structurally using nearly 50% matches in Arabidopsis (cryptochrome 3: 2IJG) and or equally suitable cyanobacterium Synechocystis (1NP7). The 14 exons share only one match with vertebrate CRY1 and CRY2 which is more likely coincidental than indicative of a common ancestor subsequent to the era of eukaryotic intronation onset.
>DASH_taeGut Taeniopygia guttata (finch) ABQF01044665 ABQF01044669 ABQF01044671 synteny: ACAA1 DASH MYD66 OXSR1 0 MSGTAGTAICLLRCDLRAHDNQ 0 0 QVLHWAQHNADFVIPLYCFDPRHYLGTHCYRLPKTGPHRLRFLLESVKDLRETLKKKGS 2 1 TLVVRKGKPEDVVCDLITQLGSVTAVVFHEE 0 0 ATQEELDVEKGLCQVCRQHGVKIQTFWGSTLYHRDDLPFRPIDR 2 1 LPDVYTHFPKGLESGAKVRPTLRMADQLKPLAPGLEEGSIPTMEDFGQK 1 2 DPVADPRTAFPCSGGETQALMRLQYYFWDT 0 0 NLVASYKETRNGLVGMDYSTKFAPW 2 1 LALGCISPRYIYEQIQKYERERTANESTYW 2 1 VLFELLWRDYFRFVALKYGRRIFSLR 1 2 GLQSKDIPWKKDLQLFSCWQ 0 0 EGKTGVPFVDANMRELSATGFMSNRGRQNVASFLTKDLGLDWRMGAEWFEYLL 0 0 VDYDVCSNYGNWLYSAGIGNDPRDNRKFNMIKQGLDYDGN 0 0 GDYVRLWVPELQGIKGADIHTPWALSSAALSQAGVTLGETYPQPVVTAPEWSRHIHRRP 0 0 GGSPHPRGRRGPAQRKDRGIDFYFSRKKDAC* 0 >DASH_anaPla Anas platyrhynchos (duck) scaffold1769 0 0 0 QVLHWAASNADYLIPLYCFDPRHYAGTHCYGFPKTGPHRLRFLLESVKDLRETLKKKGS 2 1 TLVVRKGKPEDVVRDLITQLGCVGVVAFHEE 0 0 ATQEELDVEKELCQVCEQHGVKVQPFWAATLYHRDDLPFGPIAR 2 1 LPDVYTQFRKAVEAEAKVRPALQLPDQLKPLAPGVEEGCIPTMEDLGQK 1 2 DPGTDPRTAFPCCGGETQALARLQYYFWDT 0 0 NLVASYKETRNGLIGMDYSTKFAPW 2 1 LALGCISPRYIYEQLRKYEKERGANDSTYW 2 1 VLFELLWRDYFRFVALKHGRRIFSVR 1 2 GLQSKEVPWKKDLQLFDCWK 0 0 EGKTGVPFVDANMRELAATGFMSNRGRQNVASFLTKDLGLDWRMGAEWFEHLL 0 0 VDYDVCSNYGNWLYSAGVGNDPRDKRKFNVIKQGLDYDGN 0 0 GDFVRLWLPELQGIAGADAHAPWALSSTALRQAGIILGQTYPQPLVRAPEWSRHINQRL 0 0 GRSPHPRGRRGPADAPAQRKDRGIDFYFSRKKDE* 0 >DASH_melUnd Melopsittacus undulatus (budgerigar) AGAI01061648 0 msgtSARTAICLLRCDLRAHDNQ 0 0 QVLHWAQSNAEFVVPLYCFDPRHYLRTHWYGFPKTGPYRLRFLLESVKDLRETLKKKGS 2 1 TLVVRKGKPEDVVRDLITQLGSVSAVVFHEE 0 0 ATQEELDVENELCQVCSQHGVKVYTFWASTLYHRDDLPFRPIAR 2 1 LPDVYTHFRKAVESEAKVRPTLRMADQLQPLAPGVEEGCIPTMEDFGQK 1 2 DPDTDPRTAFPGSGGETQALMRLQYIYFWDT 0 0 NLVASYKEVRNGLVGMDYSTKFAPW 2 1 LALGCISPRYIYEQIKKYERERTANQSTYW 2 1 VLFELLWRDYFRFVALKYGRRIFSLR 1 2 GLQSKEVPWKKDLQLFNCWK 0 0 EGKTGVPFVDANMRELAATGFMSNRGRQNVASFLTKDLGLDWRMGAEWFEYLL 0 0 VDYDVCSNYGNWLYSAGVGNDPRDNRKFNMVKQGLDYDGN 0 0 GDYVRLWVPELQGIKGADIHTPWALSSAALSQAGVTLGETYPQPIVTAVEWSRHISQRP 0 0 GRSLHPRGSRRPAHSPVQHKDRGIDFYFSRKKDA* 0 >DASH_galGal Gallus gallus (chicken) syntentic pseudogene, numerous indels, frameshifts, internal stops 0 0 0 2 1 MVVRKGKLEDMVHDVITSLGCVGVVAFHEE 0 0 2 1 IQPDVYTNF*KAVESEVKTWPALQRADQLKPLAGG&^EEGCIPTTEDLGQK 1 2 DPGTDPQTAF-LGFNETAAL 0 0 LLFASYNETWSGLIGVD*STKFAPW 2 1 LVLGCLSP*YIFSQIGKYVKERAANHST*W 2 1 AVFELLWWDCF*FVALKYGRRILSLK 1 2 0 0 LGLDWRMGAEWFEYLL 0 0 VDYNVFSN*STWLYSAGIGNHPKDNRKFNVIKQGPDYDGN 0 0 GDCIQLRVTELQGMKEADIHSPWALNSATLSQVGVTLGKTYPQVQSDSP^EWSRQIRQRA 0 0 GRSPHPKGRRGPAHSPLQHKERGTDCFSLKK* 0 >DASH_melGal Meleagris gallopavo (turkey) ADDD01036185 syntenic pseudogene 0 0 0 2 1 0 0 2 1 DVYTNL*KAVESEVKVWPALQRADQLKPLA-GSGRKMYPYNKGFG 1 2 0 0 LFASYKEIWSGLTGADNSTKFAPW 2 1 LVLDCLSP*CIFSQVQKYIKERAANQSTFW 2 1 VFELLWWDCF*FVPLKYGRRIFSL 1 2 0 0 LKVDYNVPNN*VT*LYSADIGNHPKENRKFNMIKEGPNDDG 0 0 VPELQGIKGPDIHSPWALNSASVFQVGGTLVETYPQPAV 0 0 * 0 >DASH_anoCar Anolis carolinensis (lizard) XM_003221869 14 exons 0 MASSLPRTALCLLRNDLRCHDNE 0 0 VLHWAQSHADRIVPLYCFDPRHYAQTYHYNFPKTGPFRLRFLLESVKDLRETLKKKGS 2 1 NLVVRKGKPEDVVRDLIIQLGSVASVSFHEE 0 0 ATKEELDVEKALIRVCTEHGVEVQTFWGSTLYHRQDLPFKHISQ 2 1 LPDVYTQFRKAVESQARVRPVLKMEGQMKSLPPEIEEGNIPSLEDFGMT 1 2 EPLRDPRSAFLCSGGETQALMRLQHYFWET 0 0 NLVASYKETRNGLIGLDYSTKFAPW 2 1 LALGCISPRYIYDQIQKYEKERTANQSTYW 2 1 VLFELAWRDYFRFVALKYGRKIFFPR 1 2 GLQDKDISWKKDPKLFDAWK 0 0 EGRTGVPFVDANMRELATTGFMSNRGRQNVASFLTKDLGLDWRMGAEWFESLL 0 0 VDYDVCSNYGNWLYSAGIGNDPRENRKFNMIKQALDYDGN 0 0 GDYARLWVPELQCIRGGDVHTPWALSNGALSQAGVSLGSSYPVPIIKAPEWGRHINQKPVSM 0 0 SNQGPKGRKGPSHTPKQHKNRGVDFYFSHKKDLS* 0 >DASH_chrPic Chrysemys picta (turtle) AHGY01416294 first exon off contig 0 0 0 VLRWAQNNADYVIPLYCFDPRQYLRTYYYGFPKTGPHRLKFLLESVKDLRQTLKKKGS 2 1 NLVVRKGNPEDVVHDLITQLGSVTAVAFHEE 0 0 ATKEELDVEKALQRVCVQHGVKIQTFWASTLYHRDDLPFRHISR 2 1 LPDVYTQFRKAVEAQAKVRPTVQMPDQLKPLAPGVEDGCIPVPEEFGQK 1 2 DPLTDPRTAFPCCGGETQALMRLQHYFWDT 0 0 NLVASYKETRNGLIGIDYSTKFAPW 2 1 LALGCISPRYIYEQIRKYEKERTANQSTYW 2 1 VIFELLWRDYFRFVALKYGTRIFLLK 1 2 GLQDKEVPWKKDPKLFDAWK 0 0 EGRTGVPFVDANMRELAATGFMSNRGRQNVASFLTKDLGLDWRMGAEWFEYLL 0 0 VDYDVCSNYGNWLYSAGIGNDPRENRKFNMIKQGLDYDSN 0 0 GDYVRLWVPEIQCVKGGEIHTLWALSNAALSQAGIALGETYPLPVVLAREWSRHINQKP 0 0 RDHPPRGRKDPSDTPRQHKDRGMDFYFSRNKDLS* 0 >DASH_xenTro Xenopus tropicalis (frog) XM_002938001 PubMed:15147276 synteny: ACAA1 DASH MYD66 transcripts AL790297 CR419606 etc 0 MAARARVIICLLRNDLRLHDNE 0 0 VLHWAHRNADQIVPLYCFDPRHYGGTHYFNFPKTGPHRLKFLLESVQDLRNTLKERGS 2 1 NLLLRRGKPEEIIAGLVKQLGNVSAVTLHEE 0 0 ATKEETDVESAVRRVCTQLGVRYQTFWGSTLYHREDLPFRHISS 2 1 LPDVYTQFRKAAETQGKVRSTFQMPDRLKPLPSGLEEGSVPTHQDFDQQ 1 2 DPLTDPRSAFPCCGGETQALQRLHHYFWET 0 0 NLVASYKDTRNGLIGIDYSTKFAPW 2 1 LALGCISPRYIYEQIRKYEKERTANQSTYW 2 1 VIFELLWRDYFRFVALKYGRRIFFLR 1 2 GLQDKDVPWKKDPKLFDAWK 0 0 EGRTGVPFVDANMRELAMTGFMSNRGRQNVASFLTKDLXIDWRLGAEWFEYLL 0 0 VDYDVCSNYGNWLYSAGIGNDPRENRKFNMIKQGLDYDAG 0 0 GDYIRLWVPELQQIKGGDAHTPWALSTASLAHSNVSLGETYPYPIVMAPEWSRHINQKPSGS 0 0 WETSARRGKGPSHTPKQHRNRGIDFYFSRNKNV* 0 >DASH_hymCut Hymenochirus curtipes (frog) 1 QMPKLKPLPDGLEEGKVPTYEEFDQE 1 2 DPLTDPRTAFPCSGGETQALQRLHHYFWDT 0 0 NLVPPYKDTRNGLIGLDYSTKLAPW 2 1 LALGCVSPRFIYEQIKKYEQERTANQSTYW 0 0 VIFELLWRDYFRFVALKYGRRIFFLR 1 2 GLAHTNV >DASH_ambMex Ambystoma mexicanum (axolotl) CO785483 0 MSVQARTIICLLRNDLRFHDNE 0 0 VLLWALKNAERIVPLYCFDPRHYVGTHNYNFPKTGPHRLKFLLESVKDLRETLKKKGS 2 1 NLLVRKGKPEDVIQELLKQLGSVSAVAFHNE 0 0 VTKEELDVEAAVKQVCvqhgGKIQTFWGSTLYHRDDLPFRHISR 2 1 LPDVYTQFRKGVESQGTSAATLQMPQKVPPLPSGLE >DASH_oreNil Oreochromis niloticus (tilapa) XM_003439198 0 MSSSRTVICLLRNDLRLHDNE 0 0 LFHWAQRNAEHIVPLYCFDPTHYVGTYNYSLPKTGPFRLRFLLEGIRDLRNTLINKGS 2 1 NLVVRRGKPEEVVADLIRQLGSVSSVAFHEE 0 0 VTSEELNVEKRVKDVCAQMKVKVHTCWGSTLYHRDDLPFPHMSR 2 1 LPDVYTQFRKAVESEGRVRPVFSTPEKLNPLPPGLEEGAIPTAEDLQQT 1 2 EPVTDPRSAFPCGGGESQALARLKHYFWDT 0 0 DAVATYKETRNGLIGVDYSTKFSPW 2 1 LAMGCISPRYIYHQIKQYEKERTANQSTYW 2 1 VIFELLWRDYFRFVSVKYGNRIFQVK 1 2 GLQDKSVPWKKDMKLFDAWK 0 0 EGRTGVPFVDANMRELAATGFMSNRGRQNVASFLTKDLGLDWRMGAEWFESLL 0 0 IDHDVCSNYGNWLYSAGIGNDPRENRKFNMIKQGLDYDNN 0 0 GDYVRGWVPELQNIRGGDVHTPWALSTAVLAHAHVTLGDTYPAPIVTAPEWSRHVNKKAGGT 0 0 GPSPRGKKGPSHTPKQHRDRGIDFYFSRSKNL* 0 >DASH_danRer Danio rerio (zebrafish) NM_205686 0 MSASRTVICLLRNDLRLHDNE 0 0 VFHWAQRNAEHIIPLYCFDPRHYQGTYHYNFPKTGPFRLRFLLDSVKDLRALLKKHGS 2 1 TLLVRQGKPEDVVCELIKQLGSVSTVAFHEE 0 0 VASEEKSVEEKLKEICCQNKVRVQTFWGSTLYHRDDLPFSHIGG 2 1 LPDVYTQFRKAVEAQGRVRPVLSTPEQVKSPPSGLEEGPIPTFDSLGQT 1 2 EPLDDCRSAFPCRGGETEALARLKHYFWDT 0 0 NAVATYKETRNGMIGVDFSTKFSPW 2 1 LALGCISPRYIYEQIKKYEVERTANQSTYW 2 1 VIFELLWRDYFKFVALKYGNRIFYMN 1 2 GLQDKHVPWKTDMKMFDAWK 0 0 EGRTGVPFVDANMRELALTGFMSNRGRQNVASFLTKDLGLDWRLGAEWFEYLL 0 0 VDHDVCSNYGNWLYSAGIGNDPRENRKFNMIKQGLDYDNN 0 0 GDYVRQWVPELRGIKGGDVHTPWTLSNSALSHAQVSLNQTYPCPIITAPEWSRHVNNKS 0 0 SGPSSSKGRKGSSYTARQHKDRGIDFYFSKNKHF* 0 >DASH_patPec Patiria pectinifera (starfish) HP101597 0 MAGRMKIIICLLRNDLRYRDNE 0 0 VLHWAHQNADILPLYCLDPRHYHGTWHFSFPKTGPHRLKFLLESLRDLKETLRQVGS 2 1 NLVISRGKPETVIQDLIRQLGQDNVKAVALQQE 0 0 ATREELDVEAAIEKSCQVPVHKFWGSTLYHKDDIPFRIRD 2 1 LPNVFTEFRKKTENQSDVRPTLPMPSKLKPLPPGIDPGHAPSVEEMGMK 1 2 DPASDERTAFPYSGGEKQALARIQHYFWDY 0 0 DYVSSYKETRNGLIGGDYSTKFSSW 2 1 LALGCLSPRKIYEEIRKYEKERRANQSTYW 2 1 VVFELLWRDYFKFVALKFGDRLFYLS 1 2 GLLGNHREWRENKALFDAWR 0 0 EGRTGVPFVDANMRELAATGFMSNRGRQNVASFLTKDLKLDWRLGAEWFEHLL 0 0 IDHDVCSNYGNWLYCAGVGNDPRQDRKFNMIKQGLDYDAQ 0 0 GDYVRLWVPELQGIKGGAVHTPWILSSSMLIQANVRLGHTYPLPVVKAPEWNKHMRP 0 0 QERGKSGKGPGQRQQTRGIDFYFSSGKQGKFKK* 0 >DASH_strPur Strongylocentrotus purpuratus (urchin) 0 MAGRMKIIICLLRNDLRYRDNE 0 0 VLFWAHKNATNVIPLYCFDPRHYKGTHQFGFPKTGPHRLKFLLESVRDLRTTLQSVGS 2 1 GLVVRSGNPEDVVPQLIQQFGEGEVAAVALQEE 0 0 ATREELDVEAGLHQSCSKLGVNVKKFWGSTLYHREDVPFSPG 2 1 VPNVYTEFRKKVENRSHVRPPINMPKPLKGLPEGVEEGDIPVFSSFGLK 1 2 DPGSDSRTAFPFQGGETTGLARIEDYFWKS 0 0 DCIAKYKETRNGLIGSEYSTKFAAW 2 1 LAHGCVSPRQIHAEVKRYEKERTENQSTYW 2 1 VIFELIWRDYFKFVALKFGDKMFYLS 1 2 GLLGVHKPWNKNKQWFDAWC 0 0 KGQTGVPFVDANIREMAATGFMSNRGRQNVASFLTKDLVLDWRLGAEWFEQML 0 0 VDHDVTSNYGNWLYSAGVGNDPRQDRKFNMIKQGLDYDPN 0 0 GDYIRLWVPELSGIKGGSIHMPWTLSSAQLNQAGVSLGETYPSPIVTAPEWSRHSKRP 0 0 qsgrggaggsqgggsqgGGRNQSGKGQRRNQGPPRGQQRGLDFYFSNPSQK* 0 >DASH_nemVec Nematostella vectensis (sea_anemone) XP_001623243 ABAV01026885 0 MATSKTQKTVICLLRNDLRYHDNEALLWAHKNADFVLPLYCFDPDHYKTTWRFSLPKTAQYRAKFLLESVTDLRSTLQIHGSNLIIRQCQPLEAVTKLTE LLKPVAPVTSIVFQQEVTYEELNVEKALVEFCKKSGIHMHTIWGSTLFHKDDIPYKAKTVPDTYTQFRKGVENQSTVRNLIDMPKNLKPLPPVKGELGTI PDLKSLLNDSEIKEVDQRSAFPFMGGEQEALSRLGSYLWGTDSVAKYKETRNGLLGENYSTKLSPWLANGSLSPRMVYHRIKQYEEERVANHSTYWVLFE LIWRDYFKFVCLKYGDRVFYRSGIMGKSLPWKHDKMTFKLWCEGKTGVPFVDANMRELKETGWMSNRGRQNVASFLIK 0 0 DLGLDWRYGAEWFESLLLDHDVCSNYGNWNYAAGIGNDPREGRKFNMVKQGLDYDPDGDYIKTWVPELAKIPGAKVHVPWTLKPGELR 2 1 SSGVELGVTYPNPIVIAPEWARHTSKTISGKKPSNFNPRQKGVDFYFKSANNGPSGSR* 0 >DASH_monBre Monosiga brevicollis (choanoflagellate) XP_001745157 ABFJ01000402 0 MAKAGNPRPVVVWFRNDLRVHDNEVLLQAAK 0 0 ASHNHVVPVYCFDIRQ 1 2 YSLVITHRSRRCGQFPKCGRPRARFLIESVDDLRTRLQELGSGLVVRTGLPEEEVARVAAQVGATQVFAHQEVCSEEVAAEHRLKRQLEVPLSLHWGAVTLCHLDDLDFGPRCKHLPSVFTQFRKRVEADMHVRPVVAAPARLAPLPSDLELGSIPTVEDLCPGQH 0 0 EPDERAVLPFKGGETAARARLQYYLWESNLLAS 2 1 YKDTRNGLVGGDYSSKFSPWLAHGNLTARWIYHE 0 0 VKRYEQERTENTSTYWLIFELLWRDYFRFVALQHGTAIFKP 1 2 GGVQHKDVPWRHSPADFEAWQNGQTGFPFIDANMRELAKTGFMSNRGRQNVASFLTK 0 0 DLQIDWRLGAEWFETLLLDHDPCSNY 1 2 GNWNYAAGVGNDPRQGRHFNVIKQ 1 2 AKTYDPTAEYVHLWVPELRGLDAPQAHVPFK 0 0 LSSEELAQANIQLGSTYPRPVVDRLDGGRLPLKVRDETAYGPHVQLPQQGLIKMILFDTLFTGLSW* 0
Cryptochrome 6-4 photolyases
>CRY64_anoCar Anolis carolinensis (lizard) XM_003225714 6-4 photolyase synteny: DCPS TIRAP CRY64 SRPR FOXRED1 0 MAHVSIHWFRKGLRLHDNPALLAAMKNSAEIYPIFILDPWFPKNMQVSINRWRFLIESLKDLDESLKKLNSR 2 1 LFVVRGRPAEVFPELFTKWKVTRLAFEVDTEPYARRDAEVVRLAAEHGVQVIQKVSHTLYDTER 2 1 IIVENSGKAPLTYTRLQTLVASLGPPKQPVPAPKLEDMK 1 2 DCCTPVKEDHDLEYGTPSYEELGQDPKTAGPHLYPGGETEALARLDLHMKRT 0 0 SWVCNFKKPETHPNSLTPSTTVLSPYVKFGCLSVRMFWWKLAEVYQG 0 0 RKHSDPPVSLHGQLLWREFFYTAGAGIPNFDRMENNPVCVQVDWDNNQEYLRAWRE 0 0 GQTGYPFIDAIMTQLRTEGWIHHLARHAVACFLTRGDLWISWEEGQ 0 0 VFEELLLDADWSLNAANWQWLSASAFFHQFFRVYSPVTFGKKTDKNGEYIK 2 1 KYLPFLRKFSNDYIYEPWKAPRSLQERAGCIIGQDYPKPIVEHEKVYKRNLERMKAAYARRSPNLVIQAKDKVSQKKGV 1 2 NRKRPEAPTKAKVQAKKVKTKSS* 0 >CRY64_chrPic Chrysemys picta (turtle) AHGY01135270 AHGY01135271 no synteny 0 MKHVSIHWFRKGLRLHDNPALLAATTDCRKLYPIFVLDPWFPKNMRVSVNRWRFLVESLRDLDESLQKLNSR 2 1 LFVVRGRPTEIFPVLFKEWKVTRLTFEVDTEPYSRQRDSEVASLAAEHGVQVIQKVSNTLYDTDR 2 1 VIAENNGKVPLTYVRLQTLLATLGPPKRPVPAPTLENLK 1 2 DCCTPCKDNHDAEYGIPTLEELGQDPEQAGLRLYPGGESEALCRLDLHMNRT 0 0 AWVCNFQKPQTEPNSLNPSTTVLSPYIKFGCLSVRTFWWRLAEVYQG 0 0 KHSNPPVSLHGQLLWREFFYTAGAGIPNFNKMEGNPVCVQVDWDNNPEHLRAWSE 0 0 GRTGYPFIDAIMAQLRTEGWIHHLARHAVACFLTRGDLWISWEQGQ 0 0 VFEELLLDADWSLNAGNWQWLSASAFFHQFFRVYSPIAFGKKTDKSGEYIK 2 1 KYLPFLRKFPAEYIYEPWKAPRSMQEQAGCVIGRDYPKPIVVHEVVSKRNVERMKAAYARRSSSTTAQLEGGGGKKGIN 1 2 GAKRRTPAGPSVAELLTKKPKT * 0 >CRY64_allMis Alligator mississippiensis (alligator) 0 MKHSCIHWFRKGLRLHDNPALLAAMKDCSELYPIFILDPWFPKNMQVSVNRWRFLVESLKDLDESLKKLNSR 2 1 LFVVRGHPAEVFPGLFKAWKVTRLTFEVDTEPYSKQRDAEVVRLAAAHGVQVIQKVSHTLYDTDR 2 1 VIAENNGKVPLTYRQLQAVLAGLGPPKQPVLAPTLETLK 1 2 DCCTPGRDNRDPKYEIPTLEELGQDPKEAGPCLYPGGESEALSRLAFHMKRM 0 0 TWVCNFKKPDTEPNTLSPSTTVLSPYVKFGCLSVRTFWWKLAEIYRG 0 0 KKHSSPPVSLHGQLLWREFFYTAGAGIPNFNRMEGNPICVQVDWDDNPEYVKAWKE 0 0 GRTGYPFIDAIMTQLRTEGWIHHLARHAVACFLTRGDLWVSWEEGQ 0 0 VFEELLLDADWSLNAGNWQWLSASAFFHQFFRVYSPVAFGKKTDKSGAYIK 2 1 KYLPILRKFPAEYIYEPWKAPRSMQEQAGCIIGRDYPKPIVEHEALSKRNIMRMKAAYAQRSHSKAAQVEKESTKKGN 1 2 GGKRKLPAGPSVVELLTKKPKAKSS* 0 >CRY64_croPor Crocodylus porosus (crocodile) blat/genome 0 MKHSCIHWFRKGLRLHDNPALLAAMKDCSDLYPIFILDPWFPKNMQVSVNRWRFLIESLKDLDESLKKLNSR 2 1 LFVVRGHPAEVFPGLFKAWKVTRLTFEVDTEPYSKLRDAEVVRLAAAHGVQVIQKVSHTLYDTDR 2 1 IIAENNGKVPLTYRQLQAVLAGLGSPKQPMLAPTLETLK 1 2 DCCTPARDNHDPKYEIPTLEELGQDPKEAGPRLYPGGESEALSRLDFHMKRM 0 0 TWVCNFKKPDTEPNTLSPSTTVLSPYIKFGCLSVRTFWWKLAEIYRG 0 0 KKHSSPPVSLHGQLLWREFFYTAGAGIPNFNRMEGNPICVQVDWDDNLEYVKAWKE 0 0 GRTGYPFIDAIMTQLRTEGWIHHLARHAVACFLTRGDLWVSWEEGQ 0 0 VFEELLLDADWSLNAGNWQWLSASAFFHQFFRVYSPVAFGKKTDKSGAYIK 2 1 KYLPILRKFPAEYIYEPWKAPRSMQEQAGCIIGRDYPRPIVEHEAVSKRNIMRMKAAYAQRSRSHSKSAQVEKEGTKKGN 1 2 GGKRKLPAGPSVVELLTKKPKAKSS* 0 >CRY64_xenTro Xenopus tropicalis (frog) synteny: STS1 RPL27A CRY64 FOXRED1 SRPR 0 MKHNSIHWFRKGLRLHDNPALLAAMKDCAELYPIFILDPWFPRNMKVSVNRWRFLIEALKDLDENLKKINSR 2 1 LFVVRGKPTEVFPLLFKKWKVTRLTFEVDTEPYSRQRDADVEKLAAEHNVQVIQKVSNTLYAIDR 2 1 IIAENNGKPPLTYVRFQTVLALLGPPKRPVQVPTQENMK 1 2 DCCTLWKSSYNEKYGVPTLEELGQDSLKLGPRLYPGGESEALSRLELHMKRT 0 0 TWVCNFKKPETEPNSLTPSTTVLSPYVKFGCLSARTFWWRIADIYQG 0 0 KKHSDPPVSLHGQLLWREFFYTAGVGIPNFNKMEGNTVCVQVDWGNNKEHLQAWSE 0 0 GRTGYPFIDAIMTQLRTEGWIHHLARHAVACFLTRGDLWISWEEGQK 0 0 VFEELLLDADWSLNAGNWQWLSASTFFHQFFRVYSPVAFGKKTDKNGDYIK 2 1 KYLPILKKFPAEYIYEPWKAPRSLQERAGCIIGKDYPKPIVEHDVASKQNIQRMKAAYARRSGSTAEVDKDSGQSNKN 1 2 GAKRKVAGGPSVAELFKKNKSKKD* 0 >CRY64_xenTro Xenopus laevis (frog) PubMed:19715341 19345672 9016626 0 MRHNSIHWFRKGLRLHDNPALLAAMKDCAELHPIFILDPWFPKNMQVSVNRWRFLIDALKDLDENLKKINSR 2 1 LFVVRGKPAEVFPLLFKKWKVTRLTFEVDIEPYSRQRDAEVEKLAAEHDVQVIQKVSNTLYDIDR 2 1 IIAENNGKPPLTYVRFQTVLAPLGPPKRPIKAPTLENMK 1 2 DCHTPWKSSYDEKYGVPTLEELGQDPMKLGPHLYPGGESEALSRLDLHMKRT 0 0 SWVCNFKKPETEPNSLTPSTTVLSPYVKFGCLSARTFWWKIADIYQG 0 0 KKHSDPPVSLHGQLLWREFYYTTGAGIPNFNKMEGNPVCVQVDWDNNKEHLEAWSE 0 0 GRTGYPFIDAIMTQLRTEGWIHHLARHAVACFLTRGDLWISWEEGQK 0 0 VFEELLLDADWSLNAGNWLWLSASAFFHQFFRVYSPVAFGKKTDKNGDYIK 2 1 KYLPILKKFPAEYIYEPWKSPRSLQERAGCIIGKDYPKPIVEHNVVSKQNIQRMKAAYARRSGSTEGVDKDSGQNNK 1 2 KGvKRKVAAGpSVAELFKKK* 0 >CRY64_strPur Strongylocentrotus purpuratus (urchin) XM_001189626 extra 1st exon unwarranted MCGAPRSYVEIRDSEEHSRRHVARLQFQFQSDLP 12 K 0 MPHNSTIHWFRKGLRIHDNPALLTAIQGTKVFRPIFILDPHFIESEKVGINRWRFLLETLQDLDYSFRALGTR 2 1 LFVVRGNPTTVFPEIFKKWNVTRLTFEVDTEPYARRRDQEVIELAKKNDVEVITKVSHTLYDTER 2 1 TIKANKYKPPMTYQRMVGLLSEIGAPAIPELPPLMANFT 1 2 GVATPVKPDHDNEYGVPSLEDLGLDLEGLGPRLYPGGETEGLQRMDLHLARK 0 0 WVCGFEKPKTSPNSLEPSTTVLSPYLKWGCLSPRKFYYAIKEVYAQQ 0 0 TNCTKPPVSLMGQLIWREFFYTVAAGTPNFHQMEENPICIQVPWDENPEFLAAWKE 0 0 GRTGYPYIDAIMTQLRTEGWIHHLARHSAACFLTRGDLWQSWVKGQE 0 0 VFDEWLLDADYSLNAANWMWLSSSAFFHQYYRVYSPVVFGKKTDKTGEYIR 2 1 KYIPALNKLPAEYIYEPWTAPRSVQEAAGCIIGRDYPRPIVDHSIVSKRNIGRMKDARACQPGKKA 1 2 EKRPAEPSKQDNNGKKVRKITSMLKKK* 0 >CRY64_droMel Drosophila melanogaster (fruitfly) 6-4 photolyase 3CVW CG2488 uses 5-deazariboflavin 0 MDSQRSTLVHWFRKGLRLHDNPALSHIFTAANAAPGKYFVRPIFILDPGILDWMQVGANRWRFLQQTLEDLDNQLRKLNSRLFVVRGKPAEVFPRIFKSWRVEMLTFETDIEPYSVTRDA AVQKLAKAEGVRVETHCSHTIYNPELVIAKNLGKAPITYQKFLGIVEQLKVPKVLGVPEKLKNMPTPPKDEVEQKDSAAYDCPTMKQLVKRPEELGPNKFPG 1 2 GETEALRRMEESLKDEIW VARFEKPNTAPNSLEPSTTVLSPYLKFGCLSARLFNQKLKEIIKRQPKHSQPPVSLIGQLMWREFYYTVAAAEPNFDRMLGNVYCMQIPWQEHPDHLEAWTHGRTGYPFIDAIMRQLRQE GWIHHLARHAVACFLTRGDLWISWEEGQRVFEQLLLDQDWALNAGNWMWLSASAFFHQYFRVYSPVAFGKKTDPQGHYIRKYVPELSKYPAGCIYEPWKASLVDQRAYGCVLGTDYPHRI VKHEVVHKENIKRMGAAYKVNREVRTGKEEESSFEEKSETSTSGKRKVRRATGSAPKRKR* 0 >CRY64_danPle Danaus plexippus (butterfly) EF117813 PubMed:17244599 MTKVASVIHWFRLDLRLHDNLALRNAINEAENRKQILRPIYVIDPDIKNRVGCNRLRFLFQSLKNLDTSLRKINTRLYVIKGKAIECLPKLFDEWHVKFLTL QVDIDADLVKQDEVIEEFCEANNIFVVKRMQHTVYDFNSVVKKNNGSIPLTYQKFLSLVSDVQVKDIIQISKGVSDECKASDYDSQGYDIPSLEEFGVNESELSECKYPGGESEGL KRLDVYMAKKQWVCNFEKPKSSPNSIEPSTTVLSPYISHGCLSAKLFYHKLKQVENGSKHTLPPVSLMGQLMWREFYYTAGSGTENFDKMVGNSVCTQIPWKKNDAHLKAWAEGKT GYPFVDAIMRQLKQEGWIHHLARHMVACFLTRGDLWISWEEGAKVFEDFLLDYDWSLNAGNWMWLSASAFFYKYYRVYSPVAFGKKTDKDGLYIRKYVPELKKYPSEFIYEPWKAP KGVQKTAGCIIGEGYPNRIVDHDKVHKDNIQKMNAAYKVNKEKKAMKRPRQ* 0
Cryptochrome CPD photolyases
This dna repair enzyme was studied in marsupials during the pre-genomic era (1994), with two groups concluding even that that no ortholog existed in placentals. That is still the case today despite several dozen complete placental mammal genomes. Further, no pseudogene debris exist in the partly conserved syntenic location. This strongly suggests that the gene was lost once in stem placental rather than many times in later subclades (as happened with encephalopsin). The gene remains very strongly conserved in species such as opossum in which it is still present today.
This is somewhat peculiar since CPD is a very ancient (pre-metazoan) member of the photolyase family, with highly conserved orthologs readily recoverable in other commonly studied marsupials, monotremes, birds, alligators, turtle, lizard, snakes, frog, fish, agnathan, amphioxus and sea urchin. However it also appears to be lost in tunicates -- indeed Ciona has lost all its photolyases leaving it a bit mysterious how it repairs these types of dna damage.
It is very unlikely that placentals evolved something better. More likely, they lost CPD along with most other photoproteins during a dark phase of their evolution when UV damage to their dna was a non-issue. Coming back out into the light millions of years later, they evidently use a less efficient excision repair that somewhat overlaps photolyase functionality.
The CPD gene product is very diverged from other photolyases though still retaining weak homology along its photolyase and FAD bindng domains. The antenna moiety is usually reported as MTHF folate. The best available structres are from rice (3UMV: 53% identity) and an archael methanogen (Methanosarcina mazei 2XRZ) which likely uses 5-deazariboflavin Fo as antenna (which it can synthesize de novo). The latter enzyme repairs cyclobutane pyrimidine dimers in duplex DNA using blue or near-UV light.
>CPD_monDom Monodelphis domestica (opossum) NP_001028149:wrong OPC1 PubMed:7937136 synteny: TNK1 MUC4 CPD KIAA0226 FYTTD1 0 MAPKKRSLGDGDEQEKTETQENKTKRKPLQKHQFSKSNVVQKEEENKREGEKKGGAEGLQEVVMQSRLQTASSVLEFRFNKQRVRLISQDCHLQDHSQAFVYWMSRDQRVQ 1 2 DNWAFLYAQRLALKQKLPLHVCFCLAPCFLGATIRHYDFMLRGLEEVAE 0 0 ECEKLHIPFHLLLGLPKDVLPAFVQAHSIGGIVTDFSPLLHHTQWVKDVQDGLPKQVPFVQ 0 0 VDAHNIVPCWIASDKQEYGARTIRHKIHDRLPHFLTEFPPVICHPYPSNIQAE 0 0 PVDWNACRAGLQVDRSVKEVSWAKPGTASGLTMLQSFISQRLPYFGSDRNNPNKDALSNLSPWFHF 1 2 GQVSVQRAILEVQKHRSRYPDSVANFVEEAVVRRELADNFCFYNKNYDKLE 1 2 GAYDWAQTTLRLHAKDKRPHLYSLEQLESGKTHDPLWNAAQ 0 0 MQMVQEGKMHGFLRMYWAKKILEWTRSPEEALEFAIYLNDRFQLDGRDPNGYV 1 2 GCMWSICGIHDQGWAEREIFGKIRYMNYAGCKRKFDVAEFERKYSPAD* 0 >CPD_sarHar Sarcophilus harrisii (tasmanian_devil) AEFK01107967 0 MAPKKRSHGTGSEPEKTDSQESKAKRKPLQKHPSSKNNVVQPEREDKKEGQKRAGAEGLQEAVRQARLRTAPSVLEFRFNKQRVRLISQDCHLQDHSQAFVYWMARDQRVQ 1 2 DNWAFLYAQRLALKQKLPLHVCFCLAPCFLGATLRHYDFMLRGLEEVAE 0 0 ECEKLCIPFHLLLGLPKDVLPPFVQKHSIGGIVTDFSPLVHHTQWVKDVQDALPRQVPFVQ 0 0 VDAHNIVPCWVASDKQEYGARTIRHKIHDRLPHFLTEFPPIICHPYPSSIQAE 0 0 PVDWNACRAGLQVDRSVKEVSWAKPGTAFGLTMLQSFIAERLPYFGSDRNNPNKDVLSNLSPWFHF 1 2 GQVSVQRAILEVQKHRGRYPDSVANFVEEAVVRRELADNFCFYNKNYDKLE 1 2 GAYDWAQTTLRLHAKDKRPHLYSLEQLESGKTHDPLWNAAQ 0 0 MQMVKEGKMHGFLRMYWAKKILEWTHSPEEALEFAIYLNDRFQLDGRDPNGYVG 1 2 GCMWSICGIHDQGWAEREIFGKIRYMNYAGCKRKFDVAEFERKYSPVD* 0 >CPD_potTri Potorous tridactylus (rat kangaroo) D26020 PubMed:7813451 0 MDSKKRSHSTGGEAENMESQESKAKRKPLQKHQFSKSNVVQKEEKDKTEGEEKGAEGLQEVVRQSRLRTAPSVLEFRFNKQRVRLISQDCHLQDQSQAFVYWMSRDQRVQ 1 2 DNWAFLYAQRLALKQKLPLHVCFCLAPCFLGATIRHYDFMLRGLEEVAE 0 0 ECEKLCIPFHLLLGLPKDVLPAFVQTHGIGGIVTDFSPLLHHTQWVKDVQDALPRQVPFVQ 0 0 VDAHNIVPCWVASDKQEYGARTIRHKIHDRLPHFLTEFPPVICHPYTSNVQAE 0 0 PVDWNGCRAGLQVDRSVKEVSWAKPGTASGLTMLQSFIAERLPYFGSDRNNPNKDALSNLSPWFHF 1 2 GQVSVQRAILEVQKHRSRYPDSVTNFVEEAVVRRELADNFCFYNKNYDKLE 1 2 GAYDWAQTTLRLHAKDKRPHLYSLEQLESGKTHDPLWNAAQ 0 0 MQTVKEGKMHGFLRMYWAKKILEWTRSPEEALEFAIYLNDRFQLDGWDPNGYV 1 2 GCMWSICGIHDQGWAEREIFGKIRYMNYAGCKRKFDVAEFERKISPAD* 0 >CPD_ornAna Ornithorhynchus anatinus (platypus) 0 1 2 0 0 ECEKLCIPFHLLLGLPKDVLPAFVQTHGIGGIVTDFSPLLHHTQWVKDVQDALPRQVPFVQ 0 0 VADNWAFLYAQRLALQRKLPLHVCFCLVPSFLGATIRHFGFMLGGLKEVAK 0 0 1 2 GQVSVQRAILEVRKQRHRYPDSVASFVEEAMVRRELADNFCFYNENYDKVE 1 2 DTLWNAAQ 0 0 LQMVQEGKMHGFLRMYWAKKILEWTRSPEEALEFAIHLNDRFQLDGRDPNGYV 1 2 GCMWSICGIHDQGWAEREVFGKIRYMNYAGCKRKFDVAQFEHKYSPRE* 0 >CPD_taeGut Taeniopygia guttata (finch) XM_002190577 0 1 2 DNWAFLYAQRLALKQELPLHVCFCLVPKFLGATIRHYRFMLRGLQEVAE 0 0 ECAELNIPFHLLLGYAKDVLPTFVVEHGVGGLVTDFSPLRLPRQWVEDVKERLPEDVPFAQ 0 0 VDAHNIVPCWVASPKQEYSARTIRGKIHAQLPEFLTEFPPVVPHPHLPSCPAE 0 0 PIAWEACYSSLQVDHTVKEVEWATPGTAAGMAVLKSFIAERLKSFSTHRNDPNKAALSNLSPWLHF 1 2 GQVSTQRAILEVQKQRRNYKDSVDAFVEEAVVRRELAENFCYYNENYDSVQ 1 2 GAYDWAQTTLKLHAKDKRPYLYSLQELEQGTTHDPLWNAAQ 0 0 LQMVQEGKMHGFLRMYWAKKILEWTRSPEEALQFAIYLNDRYELDGRDPNGYV 1 2 GCLWSICGIHDQGWAERPIFGKIRYMNYAGCKRKFDVDQFERRYTPTHSQ* 0 >CPD_melUnd Melopsittacus undulatus (budgerigar) AGAI01046895 0 MLRRQRKRKASAPEEIPRVSRKRTEQEEELHEARRRAAPSVREFKFNKKRVRLISQASDLKDGGRCILYWMSRDQRLQ 1 2 DNWAFLYAQRLALKQELPLCVCFCLVPKFLEATIRHYGFMLRGLQEVAE 0 0 ECAELNIAFHLLRGYAKDVLPAFVEEHGVGGLVTDFSPLRLPWQWVQDVREWLPEDVPFAQ 0 0 VDAHNIVPCWVASPKQEYSAYTIRRKIQAQLPEFLTEFPPVVRHPYSPSCPAE 0 0 PIAWEACYSSLEVDRTVKEVEWATPGTAAGLAVLQSFIRERLKYFGSHRNDPNKAALSNLSPWFHF 1 2 GQVSTQRAILEVQKHQHKYKESVDMFVEEAIVRRELAENFCYYNENYDSVQ 1 2 GAYPWAQTTLKLHAKDERPFLYKLQELEQGTTHDPLWNAAQ 0 0 LQMVREGKMHGFLRMYWAKKILEWTHSPEEALQFAIYLNDRYELDGMDPNGYV 1 2 GCLWSICGIHDHGWTERAVFGKIRYMNYAGCKRKFDVRQFERRYAPCTLSQ* 0 >CPD_galGal Gallus gallus (chicken) XM_422729 0 MPRGNGKGRKERDAGREEEEAVGTLEAAVREARRRTAPSVRDFRYNKQRARLVSRGSELKEGAECILYWMCRDQRVQ 1 2 DNWAFLYAQRLALKQELPLRVCFCLVPAFLDATIRHYGFMLRGLREVAK 0 0 ECAELDIPFHVLLGCPKDVLPSFVVEHGVGGLVTDFCPLRVPRQWVEEVKERLPEDVPFAQ 0 0 VDAHNIVPCWVASPKQEYSARTIRAKIHSQLPEFLTEFPPVIRHPHPPPNPPE 0 0 PIAWDACYSSLQVDRTVTEVAWATPGTAAGLAMLQSFITERLKSFGSQRNDPNKAALSNLSPWFHF 1 2 GQVSTQRAILEVQKHRRVYKESVDAFVEEAVVRRELAENFCYYNENYDSVR 1 2 GAYDWAQSTLKLHAKDKRPFLYKLPQLEQATTHDPLWNAAQ 0 0 LQMVREGKMHGFLRMYWAKKILEWTRSPEEALQFAIYLNDRYELDGMDPNGYV 1 2 GCLWSICGIHDQGWKERDVFGKIRYMNYAGCKRKFDVDQFERRYAHCK* 0 >CPD_melGal Meleagris gallopavo (turkey) XM_003209143 0 MPRGSGKGRKERDAGREKEEAEAGAVGSLEAAVREARSRAAPSVRDFRYNKQRARLVSRGSELKEGAECILYWMCRDQRVQ 1 2 DNWAFLYAQRLALKQELPLRVCFCLVPTFLDATIRHYGFMLRGLREVAE 0 0 ECAELDIPFHLLLGCPKDVLPSFVVEHSVGGLVTDFCPLRVPRQWVEEVKERLPEDVPFAQ 0 0 VDAHNIVPCWVTSPKQEYSARTIRAKIHSKLPEFLTEFPPVIRHPHPPPNPPE 0 0 PIAWDACYSSLQVDHTVTEVAWATPGTAAGLAMLQSFITKRLKSFGSQRNDPNKAALSNLSPWFHF 1 2 GQVSTQRAILEVQKHRCAYKESVDAFVEEAVVRRELAENFCYYNENYDSVR 1 2 GAYDWAQSTLKLHAKDKRPFLYELPQLEQATTHDPLWNAAQ 0 0 LQMVQEGKMHGFLRMYWAKKILEWTRSPEEALQFAIYLNDRYELDGMDPNGYV 1 2 GCLWSICGIHDQGWKERDVFGKIRYMNYAGCKRKFDVDQFESRYTHCK* 0 >CPD_allMis Alligator mississippiensis (alligator) genome/blat 0 MFPKKQRQAAGADTEPSGSRKRGRQDAEVVPGAESLAEAVKQARRRAALSVREFKFNKKRVRLLSQESHLQDGALGILYWMSRDQRVQ 1 2 DNWAFLYAQRLALKQQLPLHVCFCLVPKFLDATIRHFGFLLKGLQEVAE 0 0 ECGELGIPFHLLQGYAKDVLPAFVTRHGIGGVVTDFSPLRVPLQWVEDVKERLPQGVPLVQ 0 0 VDAHNIVPCWVASNKQEYGARTIRPKIHAQLPEFLTEFPPIIQHPFPAAAPAQ 0 0 PIDWDACYAGLEVDRTVPEVKWATPGTAAGLAVLQAFVTRRLPGYSEYRNNPNKAALSNLSPWFHF 1 2 GQVSVQRAVLEVQKSRDRHRESVNSFVEEAVIRRELADNFCFYNKSYDQLE 1 2 GAHDWARDTLILHARDKREYLYDLHQLEQGKTHDQLWNAAQ 0 0 IQMVREGKMHGFLRMYWAKKILEWTRSPEDALRFAIYLNDRFELDGRDPNGYV 1 2 GCMWSICGTHDQGWAERNVFGKIRYMNYAGCKRKFNVGQFEHKYRP* 0 >CPD_chrPic Chrysemys picta (turtle) AHGY01112360 incomplete 0 MSQKSRNRQARGGEEISGDAARPGAAAAPRGQLKGKRKVLAEPGGAEVLTVEKRRKEGEAAEGGGAGSLGEAVRQARLQVAPSVQDFKYNKKRVRLVSQGSDLKDAAQGVVYWMSRDQRVQ 1 2 DNWAFLYAQRLALKQQLPLHVCFCLVPKFLEATIRHFGFMLKGLQEVAE 0 0 ECQELDIPFHLLIGFAKDVLPAFVTGRGLGGVVTDFSPLRVPMQWVEDVKERLPGDVPFVQ 0 0 VDAHNIVPCWVASDKQEYGARTIRRKIHDQLSEFLTEFPPLIKHPYPSTAPAE 0 0 PIDWNACRASLQVDCSVKEVTWATPGTAAGLAVLESFIGERLKSFGTDRNNPNR------------ 1 2 ---------------------SVDGFIEEAVIRRELADNFCYYNRNYDKVEG 1 2 GAYDWAKTSLKLHAQDKRSHLYELKQLEEGKTHDPLWNAAQ 0 0 LQMVHEGKMHGFLRMYWAKKILEWTRSPEEALEFTIYLNDRYELDGRDPSGYV 1 2 GCMWSICGIHDQGWAERAVFGKIRYMNYAGCKRKFDVGQFERRY-------* 0 >CPD_anoCar Anolis carolinensis (lizard) XM_003226963 0 MPQKRKKRKEPASGDCENQVEGDGGTSFGSESGDKKTEGKPEEKKPKKTAAVAKGPPLTEAVKASRLKMAPSIAEFHFNKKRVRMISENSDLKEGAQGILYWMSRDQRVQ 1 2 DNWAFLYAQRLALKQNLPLHVAFCLVPKFLEATIRQFGFMLKGLKEVAE 0 0 ECQELSIPFHLLIGFAKDTLPPFVAKHNIAGVVTDFAPLRVPMQWVQEVQERLPPDVPFVQ 0 0 VDAHNVVPCWVASEKQEYGARTIRRKIHDRLCEFLTGFPPVIQHPHQAASQAE 0 0 PIDWDACSASLEVDRSVPEVEWAKPGSAAGLLVLGEFVQERLKFFSSDRNNPNRAALSNLSPWFHF 1 2 GQVSVQRAILEVRKHRTRCRESVEAFIEEALIRRELADNFCFYNPNYDKVE 1 2 GAYEWAKTTLKLHATDKRPHLYTLKQLEEGKTHDQLWNAAQ 0 0 LQMVHEGKMHGFLRMYWAKKILEWTNSPEEALKFSIYLNDRYELDGRDPNGYV 1 2 GCMWSVCGIHDQGWAERAVFGKIRYMNYAGCTKKFDVGQFERKYNPRKIAY* 0 >CPD_pytMol Python molurus (python) 0 YNKKRVRLVSQAPELKEGAQGILYWMSRDQRVQ 1 2 DNWAFLYAQRLALKQRLPLHVCFCLVPKFLDATIRHFGFMLRGLEEVAE 0 0 ECRTLDIPFHLLIGYAKDTLPPFVAQRGIGGVVTDFSPLRLPMKWIQEVLEQLPSDVPFAQ 0 0 VDAHNIVPCWVASDKQEYGARTIRRKIHDQLAEFLTEFPPVIKHPFPVGLQEE 0 0 PISWDACYSSLQVDCSVKEVDWAKPGAASGLKVLEEFVKERLKHFASGRNNPNQAALSNLSPWFRF 1 2 GQVAVQRAILEVYKHRTRYKESVEGFIEEAVVRRELADNFCFYNPNYDKIE 1 2 GAYDWAKTTLKIHAKDKRPHLYTLKQLEEGKTHDPLWNAAQ 0 0 LQMVQDGKMHGFLRMYWAKKILEWTRSPEEALQFSIYLNDRYELDGRDPNGYV 1 2 GCMWSICGIHDQGWAERAVFGKIRYMNYAGCKRKFDVGQFERKYGAHSFTQ* 0 >CPD_xenTro Xenopus tropicalis (frog) 0 MSHKGKVSKSKDEESGSEKSDGTLTKGMRMDTKAKSKTITKSPGKRKTPGKVLSETSSGESSDVDAKKKKKMVEQTEEKGVGGAVKISRVEAAPSVSEFKFNKKRVRLvSTEADLKDDAQGIVYWMSRDQRVQ 1 2 DNWAFLYAQRLALKQKLPLHVTFCLVPKFLDATIRHYGFMVKGLQEVAE 0 0 ECKELNIPFHLLIGYAKDILPNFVKKHAIGGVVTDFSPLRVPLQWVEDVSKRLPKDVPLVQ 0 0 VDAHNIVPCWVASNKQEYGARTIRKKIHDQLSQFLTEFPPVIKHPYEPKLEAE 0 0 PVDWDNCYNSLEVDRTIGEVEWAKPGTNAGFNVLQSFISERLRHFNSDRNNPNQNALSNLSPWFHF 1 2 GQLSVQRAILEVQKYRSKCKDSVDSFVEEAVVRRELADNFCFYNKNYDKIE 1 2 GAYDWAKNTLKDHAKDKRTHLYTLEKLEAGKTHDPLWNAAQ 0 0 LQMVHEGKMHGFLRMYWAKKILEWTSSPEEALHFSLYLNDRYELDGRDPNGYV 1 2 GCMWSICGIHDQGWAERAVFGKIRYMNYQGCKRKFDVAQFERRYHPKKFSQ* 0 >CPD_danRer Danio rerio (zebrafish) NM_201064 0 MSANKNNLKRQMKSTISAGGKQPKLTGEKGKESGWLLKEVAELRRAAQGCEFNKKRLRYLSDTQKVKQSSQGVLYWMSRDQRIQ 1 2 DNWALIYSQQLALAEKLPLHICFCLVPKFLDATYRQYAFMLKGLQEVVK 0 0 ECKSLDIEFHLLSGEPVHNLPAFVKSWNIGAVVTDFNPLRISLQWIDTVKKHLPSDIPFIQ 0 0 VDAHNVVPCWEASTKLEYGARTIRGKITKHLQEFLTDMPLVDTHPYCASRAAK 0 0 IIDWEEVLSSLEVDHNVCEVEWAQPGTTGGMFMLESFIDQRLHIFATHRNNPNSDAVSHLSPWIHA 1 2 GQLSAQRVVMQVKRKKNASESVASFIEEIVVRRELADNFCFYNQNYDNIS 1 2 GAYDWAKKTLQEHAKDRRQYLYTKKELESAETHDQLWNAAQ 0 0 RQLLLEGKMHGFLRMYWAKKILEWTASPEEALSIAIYLNDRLSLDGCDPNGYV 1 2 GCMWSICGIHDQGWAERPIFGKIRYMNYAGCKRKFDVEQFERKYAAIKKNPNLNAKISV* 0 >CPD_petMar Petromyzon marinus (lamprey) rough but revised sequence 0 MCLSRLTIVFKLSSWLVNVVGSGNFEEQISKTRAALASSVLEFRFNKKRVRAVSNADDMAANASGILYWMSRDQRVQ 1 2 DNWALLYAQRLALKQRLPLYVCFCLVPKFMDATIRHFGFMLRGLQEVEK 0 0 EFRSLDISFHLLKGYAKDVLPPFVNEKNIGAVVTDFLPLRVPRQWVKDLKKALPKNVPLAQ 0 0 VDAHNVVPCWVTSDKLEYGARTIRRKIHDKLPQFFTEFPPAIKHTYPAKSLPE 0 0 ETDWEAAWQSLEVDRSVGEVAWAQPGTSAGLEMLNSFINERLKLFSTDRNNPTAMHSATSSPVIHF 1 2 1 2 GAYDWAKRSLDAHTQDNREYIYSLQQLEEAKTHDPLWNAAQ 0 0 LQMVVEGKMHGFMRMYWAKKILEWTSSPEEALRIAIYLNDRYQLDGSDPNGYV 1 2 GCMWSICGTHDQGWAERAVFGKIRYMNYAGCKRKFDVGAYESRYSSK* 0 >CPD_braFlo Branchiostoma floridae (amphioxus) XP_002586934 FE570347 0 MSSGDKRKSSGSGDSPAKKAKVETGRSSAQDGAGSEDFLDQIAERRQNVCESVAGFKFNKKRCRQMSDVGDLKQNCGGIMYWMSRDQRVQ 1 2 DNWALLFAQRLAMKHKVPLYVCFCLVPKFLDANIRHYGFMLKGLEEVEK 0 0 FPSPDWLCCGFLPGFVDEKNIGGVVTDFSPLRTPLKWVHDLAGKLPSDVPFVQ 0 0 VDAHNIVPCWEASPKQEYGARTIRGKIHNQLSSYLTEFPPVSQHPHPPKDKPE 0 0 PTDWAAARASLKVDMTVAEVTWATPGTTGGLRMLESFCKQRLKNFGTDRNNPNKRALSNLSPWIHF 1 2 GQISVQRCILTVKKYRSKYKESVDAYIEEAIIRRELSDNFCFYNHDKYDSIK 1 2 GASAWAQKTLKDHAGDKREYLYSREQLEQAKTHDDLWNAAQ 0 0 DKYSLDGRDPNGYV 1 2 GCMWSICGIHDQGWAERPVFGKIRFMNYNGCKRKFDVAQFVTKYKAKGYLKK* 0 >CPD_strPur Strongylocentrotus purpuratus (urchin) JT122393 JT102939 FJ812411 0 MITFSVQGLKLGHHCQCWKVVFLSRFISSRSYSSIMGKDGQTAKRSSEGQDNGETSAAKKVKKEEDGAEVQDLQTKVASLRNASGSSILNFKFNKKRVKILSDTMDIAEDNRGIVYWMSRDQRVQ 1 2 DNWALLFAQRLAMKQEVPLHVCFCLVPKFLEGTIRHFNFVLEGLKEVSQ 0 0 ECKELNIPFHLLIGYAKDILPNFVKKHAIGGVVTDFSPLRVPLQWVEDVSKRLPKDVPLVQ 0 0 VDAHNVVPCWEASNKLEYGARTIRPKITKQLSTYLTEFPPVICHPQKAKAKAE 0 0 PIDWEGAYASLEVDQTVKPVDWAKPGTSEGMKMLDSFVKERLRYFSSARNDPTKSVCSNLSPWIHF 1 2 GQLSSQRAALIVRLYRSRFSESVAAFIEESIIRRELSDNFCFYNDKYDSIE 1 2 GTNDWAKKTLKDHAKDKRDYVYSRETLERAKTYDQLWNSAQ 0 0 KQMVREGKMHGFLRMYWAKKILEWTTSPEEALEIAIYLNDRYSLDGRDPNGYV 1 2 GCMWSICGIHDQGWGERPVFGKIRFMNYKGCKRKFDVDTFVNRYKKYNL* 0 >CPD_droMel Drosophila melanogaster (fruitfly) thymidine dimer photolyase CG11205 uses 5-deazariboflavin 0 MFTLASYWRESFKI 0 0 VLPLQAMKRTKAQKAGPSKKAAKNEKASSEPKSDQESSDEEASTSKALLVSKPDYQNFEQFLTHLEHQRVCTAANIQEFSFRKKRVRVLSKTEDVKESSL GGVVYWMSRDGRVQDNWALLFAQRLALKLELPLTVVFCLVPKFLNATIRHYKFMMGGLQEVEQQCRALDIPFHLLMGSAVEKLPQFVKSKDIGAVVCDFA PLRLPRQWVEDVGKALPKSVPLVQVDAHNVVPLWVASDKQEYAARTIRNKINSKLGEYLSEFPPVVRHPHGTGCKNVNTVDWSAAYASLQCDMEVDEVQW AKPGYKAACQQLYEFCSRRLRHFNDKRNDPTADALSGLSPWLHFGHISAQRCALEVQRFRGQHKASADAFCEEAIVRRELADNFCFYNEHYDSLKGLSSWAYQTLDAHRKDKRDPCYSLEELEK 0 0 SLTYDDLWNSAQLQLVREGKMHGFLRMYWAKKILEWTATPEHALEYAILLNDKYSLDGRDPNGYVGCMWSIGGVHDMGWKERAIFGKVRYMNYQGCRRKFDVNAFVMRYGGKVHKKK* 0
Fish cryptochrome sets
The situation in ray-finned fish is quite complicated because of gene duplication with retention. The full set of cryptochromes in some model species have been determined and those are predominantly what is provided here, using that nomenclature for the moment. These entries have not yet been curated.
>CRY1A_danRer Danio rerio (zebrafish) BC134838 MVVNTVHWFRKGLRLHDNPSLRDSILGAHSVRCVYILDPWFAGSSNVGISRWRFLLQCLEDLDASLRKLNSRLFVIRGQPTDVFPRLFKEWNINRLSYEYDS EPFGKERDAAIKKLANEAGVEVIVRISHTLYDLDKIIELNGGQSPLTYKRFQTLISRMEAVETPAETITAEVMGPCTTPLSDDHDEKFGVPSLEELGFDTEGLSSAVWPGGETEAL TRLERHLERKAWVANFERPRMNANSLLASPTGLSPYLRFGCLSCRLFYFKLTDLYRKVKKNSSPPLSLYGQLLWREFFYTAATNNPRFDKMEGNPICVQIPWDKNPEALAKWAEGR TGFPWIDAIMTQLRQEGWIHHLARHAVACFLTRGDLWISWEEGMKVFEELLLDADWSVNAGSWMWLSCSSFFQQFFHCYCPVSFGRRTDPNGDYIRRYLPVLRGFPAKYIYDPWNA PESVQKAAKCIIGVHYPMPMVHHAEASRLNIERMKQIYQQLSCYRGLGLLAMVPSNPNGNGENSTSLMGFKTGDMTKEVTTPSGYQMPPTSQGEWHGRTMVYSQGDQQTSSIMTSQ GFGNNGSTMCYRQDAQQITGRGLHSSIIQTSGKRHSEESGPTTVSKVQRQCSS >CRY1B_danRer Danio rerio (zebrafish) BC044558 MVVNTVHWFRKGLRLHDNPSLRDSIKGADNLRCVYILDPWFAGSSNVGISRWRFLLQCLEDLDASLRKLNSRLFVIRGQPTDVFPRLFKEWKISRLSYEYDS EPFGKDRDAAIRKLATEAGVEVFVRISHTLYDLDKIIEFNGGQSPLTYKRFQTLISRMDPVEMPAETITAEIMGKCSTPVSDDHDDKFGVPSLEELGFETEGLSTAVWPGGETEAL TRLERHLERKAWVANFERPRMNANSLLASPTGLSPYLRFGCLSCRLFYFKLTDLYRKVKKNSTPSLSLYGQLLWREFFYTAATNNPHFDKMEFNPICVQIPWDRNPEALAKWAEGQ TGFPWIDAIMTQLRQEGWIHHLARHAVACFLTRGDLWISWEEGMKVFEELLLDADWSVNAGSWMWLSCSSFFQQFFHCYCPVGFGRRTDPNGDYIRRYLPILRGFPAKFIYDPWNA PESVQKVAKCIIGVHYPKPMVNHAEASRINIERMKQIYQQLSCYRGLGLLATIPSNTANNEDSNGAGPSSGDTQESTHITVHTLPASSQSEFPAFAVSCGQQLVNSVQPQPGYSGA GMVGQAHKQTQRVRGMTAFKRHGEDRTTDFPSKIQRNDGI >CRY1C_danRer Danio rerio (zebrafish) BC095305 aka CRY2A MAPNSIHWFRKGLRLHDNPALQEAVRGADTVRCVYFLDPWFAGSSNLGVNRWRFLLQCLDDLDSNLRKLNSRLFVVRGQPANVFPRLFKEWKISRLTFEYDS EPFGKERDAAIKKLAMEAGVEVIVKTSHTLYNLDKIIELNGGQPPLTYKRFQTLISRMDPPEMPVETLSNSIMGCCVTPVSEDHGDKYGVPSLEELGFDIEGLPSAVWPGGETEAL TRIERHLERKAWVANFERPRMNANSLLASPTGLSPYLRFGCLSCRLFYFKLTDLYRKVKKTSTPPLSLYGQLLWREFFYTAATTNPRFDKMEGNPICVRIPWDKNPEALAKWAEAK TGFPWIDAIMTQLRQEGWIHHLARHAVACFLTRGDLWISWEEGMKVFEELLLDADWSVNAGSWMWLSCSSFFQQFFHCYCPVGFGRRTDPNGDFIRRYLPILRGFPAKYIYDPWNA PDSVQAAAKCIIGVHYPKPMVNHAEASRLNIERMKQIYQQLSRYRGLGLLASVPSTHNGNGNGMAYSPGEQQSGTNTPAPAVSSGSVASGNRSGSILLNFDSEEHQGPSGIQQQHQ QQQQQQQQQQLGYHHMPDSGHNSRFYKSNVSHDMAGHLLHKGGSVTGKRERESERDLDGEDESLSTSHKLQRQIAEVTSVYASSGNQSSMRS >CRY1D_danRer Danio rerio (zebrafish) BC164795 aka CRY2B MSVNSVHWFRKGLRLHDNPALLEALNGADTLRCVYFLDPWFAGASNLGVNRWRFLLQSLEDLDASLRKLNSCLFVIRGQPADIFPRLFKEWKVSRLTFEFDS EPFGKERDAAIKKLACEAGVEVIVKISHTLYDLDRIIELNGGQSPLTYKRFQTLVSSMEPPDPPLSSPDRGMMGKCVTPISENHRDKYGVPLLEELGFDTEGLAPAVWPGGESEAL KRMERHLGPDSTVAWQENFERPKMNASPLMASPLGLSPYLRFGCLSCRLFYCKLTQLYKKVKKNMNPSISLYDKILWREFFYTAATNNPRFDRMEGNPICIRIPWDRNAEALAKWA EAKTGFPWIDAIMMQLRQEGWIHHLARHAVACFLTRGDLWISWEEGMKVFEELLLDADWSVNAGSWLCHSCSSFFQQFFHCYCPVGFGRRIDPNGDFIRRYLPVLRDFPAKYIYDP WNAPHDVQLAAKCVIGVDYPKPMVNHAEASRLNIERMRQIYQQLSRYRGLSLLATVPSNHIEDAAANVNRGAMAPPTRRKTRNDASSYTGVRREQPGPSGAKHRHRHSLSHRPSPY ATQSELTDHNHEFAVPQQPGRVSWPNVGGTGKKEGEAEHNCCRGDNGPSSSALKAQQQDNERREDAEGVAFST >CRY2_danRer Danio rerio (zebrafish) aka CRY3 MVVNSVHWFRKGLRLHDNPALQEALNGADTVRCVYILDPWFAGSANVGVNRWRFLLESLEDLDTSLRKLNSRLFVVRGQPTDVFPRLFKEWNVTRLTFEYDS EPYGKERDAAIIKMAQEYGVETVVRNTHTLYNPDRIIEMNNHSPPLTFKRFQAIVNRLELPRKPLPTITQEQMARCRTQISDNHDEHYGVPSLEELGFRTQGDSLHVWKGGETEAL ERLNKHLDRKAWVANFERPRISGQSLFPSPTGLSPYLRFGCLSCRVFYYNLRDLFMKLRRRSSPPLSLFGQLLWREFFYTAGTNNPNFDHMEGNPICVQIPWDHNPEALAKWAEGR TGFPWIDAIMTQLRQEGWIHHLARHAVACFLTRGDLWISWESGMKVFEELLLDADWSVNAGSWMWLSCSAFFQQFFHCYCPVGFGRRTDPSGDYIRRYIPKLKDYPNRYIYEPWNA PESVQKAANCIVGVDYPKPMINHAESSRLNIERMKQVYQQLSHYRGLSLLASVPTIQEEAEPPMSDDSQASSSSTGQASSPPHLSITAPSTPPLSESSSPNSSPTASTSVPHTQRK RVRPSETPSKQKTKVKHTSQARGLELKMDDKQ >CRY4_danRer Danio rerio (zebrafish) BC164413 MSHRTIHLFRKGLRLHDNPSLLGALASSSTLYPVYVLDRVFLQGAMHMGALRWRFLLQSLEDLDTRLRAIGSRLFVLCGSTANILRELVAQWGITQISYDTE VEPYYTRMDKDIQTVAQENGLQTYTCISHTLYDVKRIVKANGGSPPLTYKKFLHVLSVLGEPEKPARDVSIEDFQRCVTPVDVDRVYAVPSLADLGLQVEAEVLWPGGESHALQRL EKHFQSQGWVANFSKPRTIPNSLLPSTTGLSPYLSLGCLSVRTFYHRLNSIYAQSKNHSLPPVSLQGQVLWREFFYTVASATPNFTKMEGNSICLQIDWYHDPERLEKWRTAQTGF PWIDAIMTQLRQEGWIHHLARHAVACFLTRGDLWITWEEGMKVFEEFLLDADYSVNAGNWMWLSASAFFHKYTRIFCPVRFGRRTDPQGEYLRKYLPVLKNFPSQYIYEPWKAPED VQLSAGCIIGKDYPRPIVSHIEASQRNLALMRQVRTEQQTTAELTRDVADDPMEAGLKRELREEEGLLEEAESQCTSKRFSGSSDHKSRPCSWTPETLQLSELSGEVM >CRY64_danRer Danio rerio (zebrafish) BC044204 6-4 photolyase aka CRY5 MSHNTIHWFRKGLRLHDNPALIAALKDCRHIYPLFLLDPWFPKNTRIGINRWRFLIEALKDLDSSLKKLNSRLFVVRGSPTEVLPKLFKQWKITRLTFEVDTEPYSQSRDKEVMKLAKEYGVEVTPKISHTLYNIDRIIDENNGKTPMTYIR LQSVVKAMGHPKKPIPAPTNEDMRGVSTPLSDDHEEKFGIPTLEDLGLDTSSLGPHLFPGGEQEALRRLDEHMERTNWVCKFEKPKTSPNSLIPSTTV LSPYVRFGCLSARIFWWRLADVYRGKTHSDPPVSLHGQLLWREFFYTTAVGIPNFNKMEGNSACVQVDWDNNPEHLAAWREARTGFPFIDAIMTQLRQEGWIHHLARHAVACFLTR GDLWISWEEGQKVFEELLLDSDWSLNAGNWQWLSASTFFHQYFRVYSPIAFGKKTDKHGDYIKKYLPVLKKFPTEYIYEPWKAPRSVQERAGCIVGKDYPRPIVDHEVVHKKNILRMKAAYAKRSPEDKTINKGEKRKASPSIKELVQKKAKR >CPD_danRer Danio rerio (zebrafish) NM_201064 MSANKNNLKRQMKSTISAGGKQPKLTGEKGKESGWLLKEVAELRRAAQGCEFNKKRLRYLSDTQKVKQSSQGVLYWMSRDQRIQDNWALIYSQQLALAEKLP LHICFCLVPKFLDATYRQYAFMLKGLQEVVKECKSLDIEFHLLSGEPVHNLPAFVKSWNIGAVVTDFNPLRISLQWIDTVKKHLPSDIPFIQVDAHNVVPCWEASTKLEYGARTIR GKITKHLQEFLTDMPLVDTHPYCASRAAKIIDWEEVLSSLEVDHNVCEVEWAQPGTTGGMFMLESFIDQRLHIFATHRNNPNSDAVSHLSPWIHAGQLSAQRVVMQVKRKKNASES VASFIEEIVVRRELADNFCFYNQNYDNISGAYDWAKKTLQEHAKDRRQYLYTKKELESAETHDQLWNAAQRQLLLEGKMHGFLRMYWAKKILEWTASPEEALSIAIYLNDRLSLDG CDPNGYVGCMWSICGIHDQGWAERPIFGKIRYMNYAGCKRKFDVEQFERKYAAIKKNPNLNAKISV
>CRY1A_phrAnd Phreatichthys andruzzii (cavefish) GQ404476 21909239
MVVNTVHWFRKGLRLHDNPSLRDSIQGAHTVRCVYILDPWFAGSSNVGISRWR
FLLQCLEDLDASLRKLNSRLFVIRGQPTDVFPRLFK
EWNITRLSYEYDSEPFGKERDAAIKKLANEAGVEVIVRISHTLYDLDK
IIELNGGQSPLTYKRFQTLISRMEAVETPAETITAEVMGTCTTPVSDDHDEKFGVPSLEEL
GFDTEGLSSAVWPGGETEALTRLERHLERK
AWVANFERPRMNANSLLASPTGLSPYLRFGCLSCQLFYFKLTDLYRK
VKKNSSPPLSLYGQLLWREFFYTTATNNPRFDKMEGNPICVQIPWDKNPEALAKWAEGRTGFPWIDAIMTQLRQEGWIHHLARHAVACFLTRGDLWISWEEGMK
VFEELLLDADWSVNAGSWMWLSCSSFFQQFFHCYCPVSFGRRTDPNGDYIR
RYLPVLRGFPAKYIYDPWTAPESVQKAAKCIIGVHYPKPMVHHAEASRLNIERMKQIYQQLSCYCGLGLLATVPSNPN
GNGENSTTLKGFQTGDVTKEFTAPSGYQMPPTSQGEWHGRTMGYSQGDHQTNMPPQGFANSSTTMCYRQDSQQISGPAVQPGRGLHCSTIQTYGKRHSEESGPATGSKVQRQSIS
>CRY2B_phrAnd Phreatichthys andruzzii (cavefish) GQ404479
EGNPICIRIPWDRNPEALAKWAEAKTGFPWIDAIMTQLRQEGWIHYLARNAVTCFLTRGDLWINWEEGMKIFEELLLDADWSVNAGSWLCHSCSSFFQQFFH
CYCPVGFGRRIDPNGDFIRCYLPVLRDFPAKFIYDPWNAPDDVQRAAKCVIGMDYPKPMVNHAEASRLNIERMRQIYQ
>CRY3_phrAnd Phreatichthys andruzzii (cavefish) GQ404480
EALNGADTVRCVYILDPWFAGSANVGVNRWR
FLLDSLEDLDTSLRKLNSRLFVVRGQPTDVFPRLFK
EWNVTRLTFEYDSEPYGKERDAAIIKMAQEYGVQTVVRNTHTLYNPDR
IIEMNNHSPPLTFKRFQAIVNRLELPRKPLPTITQEQMARCRTQISDNHDEHYGVPSLEEL
GFKTQRDSSHVWKGGETEAMERLNKHLDRK
GWVANFERPRIITAQSLFASPTGLSPYLRFGCLSCRVFYYNLRELFMK
LRRRSSPPLSLFGQLLWREFFYTAGTNNPNFDRMEGNPICVQIPWDHNPEALAKWAEGRTGFPWIDAIMTQLRQEGWIHHLARHAVACFLTRGDLWISWESGMK
VFEELLLDADWSVNAGSWMWLSCSAFFQQFFHCYCPVGFGRRTDPSGDYIR
RYIPKLKDYPNCYIYEPWNAPESVQKAANCIVGVDYPKPMINHAESSRLNIERMKQVYQQLSHYRG
>CRY4_phrAnd Phreatichthys andruzzii (cavefish) GQ404481
LHVLTVLGEPEKPVRDVSAEDFLRCMTPAEADHEKTYAVPSLADLGLEVEFDVLWPGGETHALQRLDKHFQSQGWVTSFSKTRTVPNSLLPSSTGLSPYLSL
GCLSVRTFYHQLSSVYAQSKNHSLPPLSLQGQVLWREFFYTVASSTPNFTKMEGNPICLQIQWYHDPEALEKWRTAQTGFPWIDAIMTQLRQEGWIHHLARHAVACFLTRGDLWIS
WEEGMKVFEELLLDADYSINAGNWMWLSASAFFHKYTRIFCPVRFGRRTDPQGQYL
>CRY5_phrAnd Phreatichthys andruzzii (cavefish) GQ404482 6-4 photolyase
MSHNSIHWFRKGLRLHDNPALLAALKDCRHIYPL
FLLDPWYPNNTHIGINRWRFLIEALKDLDSSLKKLNSRLFVVSGPPAEVLPKLFEKWKITRLTFEVDT
EPYSQSRDKEVMKLAEENGVEVIPKISHTLYNIDRIIEENNGKPPMTYVRFLSVVNAIGSPKKPVPAPTKEDMKGVSTPFFEDHEEEFRIPTLEDLGLDTSSLGPNLFPGGEQEAL
RRLDEHMERTTWVCKFEKPQTSPNSIIPSTTVLSPYIRFGCLSARTFWWRLADVYRGKQHSEPPVSLHGQLLWREFFYTTAVGIPNFNRMEGNRHCVQVDWDNNPEHLAAWREART
GFPFIDAIMTQLCQEGWIHHLARHAVACFLTRGDLWISWEEGQKVFEELLLDADWSLNAGNWQWLSASAFFHQFFRV
>CRY2_tetNig Tetraodon nigroviridis (pufferfish) 0 LTA-EVSGAD--RARVM--DRGSSVHWFRKGLRLHDNPALQEALSGADSLRCVYVLDPWFAGAANVGINRWR 2 1 FLLEALEDLDCSLKKLNSRLFVVRGQPTDVFPRLLK 0 0 EWKVTRLTFEYDPEPYGKERDGAIIKMAQQFGVETIVRNSHTLYNLDR 2 2 IVEMNNNSPPLTFKRFQTIVSRLELPRRPLPSVTQQQMDKCGTPVADNHDQLYSIPSLEEL 1 1 GFRTGGLAPAVWRGGESEALERLRKHLEKK 0 0 VWVSHLEHSRANTCSLYASPAGLSPYLRFGCLSCRVFYYNLREHYIR 0 0 LCKGCSPPLSLFGQLLWREFFYTAATNNPNFDRMAGNPICVQIPWDQNPEALAKWAEGRTGFPWIDAIMTQLRQEGWIHH-ARRAVACFLTRGDLWISWEC--- 0 VFEELLLDADWSVNAGSWMWLSCSAFFQQFFKCYCPVGFGRRTDPSGDYIR 2 2 RYIPILKDYPNRYIYEPWNAPEAVQKAANCVVGVDYPRPMINHAEGSRLNIERMKQVYQQLSHYRAL 1 1 -LRAPVPS-VEGCSRPPPESPLSQAGGESQA 1 2 ----------------------------------------------- * 0 >CRY2_gasAcu Gasterosteus aculeatus (stickleback) 0 -------------------VTN---HWFRKGLRLHDNPSLADSLLGADTVRCVYILDPWFAGSSNVGIHRWR 2 1 FLLQSLQDLDSSLRKHHSRLFVIRGQPTDVFPRLFK 0 0 EWNTSRLSYEYDSEPFGKERDAAIRKLACEAGVEVTVRVSHTLYDPDR 2 1 IIELNGGQSPLTYKRFQTLIGRMESPRSP-ADDV---MGKCRTPMEDHDDK--GVPSLEEL 1 1 GFDTEGLSSAVWPGGETEALARLERHLERK 0 0 AWVANFERPRMNANSLLASPTGLSPYLRFGCLSCRLFYFKLTDLYMK 0 0 VKKNSSPPLSLYGQLLWREFFYTAATNNPRFDKMESNPICVQIPWDRDPEALAKWAEGRTGFPWIDAIMTQLRREGWIHHLARHAVACFLTRGDLWIGWEE--- 0 VFEELLLDADWSVNAGSWMWLSCSSFFQQFFHCYCPVGFGRRADPNGDYIR 2 2 RYLPILRGFPAEYIYDPWNAPESVQKAAECVIGVHYPKPMVNHAHASRLNIERMKQIYQQLSCCRGF 1 1 ------------------------------- 1 2 ----------------------------------------------- * 0 >CRY2_oryLat Oryzias latipes (medaka) 0 -----------------------SVHWFRKGLRLHDNPALQEALNGADTVRCVYILDPWFAGAANVGINRWR 2 1 FLLEALEDLDCSLKKLNSRLFVVRGQPTDVFPRLFK 0 0 EWNVTRLTFEYDPEPYGKERDGAIIKMAQEFGVETVVRNSHTLYNLDR 2 1 IIELNNNSPPLTFKRFQTIVSRLELPRRPLPAITQQQMDSCQRQIGDNHDQLYSIPSLEEL 1 1 GFRTERLPPAVWRGGESEALDRLSKHLDKK 0 0 VWVASVEHTRVNKCSLYASPTGLSPYLRFGCLSCRVLYYNLRELYMK 0 0 LRKRCSPPLSLFGQLLWREFFYTAATNNPNFDRMEGNPI--QIPWDQNPEALAKWAEGRTGFPWIDAIMTQLRQEGWIHHLARHAVACFLTRGDLWISWVSGMK 0 VFEELLLDAGWSVNAGSWMWLSCSAFFQQFFHCYCPVGFGRRTDPSGDYIR 2 2 RYIPILKDFPNRYIYEPWNAPESVQKAANCVVGVDYPKPMVNHAESSRLNIERMKQVYQQLSHYRGL 1 1 ------------------------------- 1 2 ----------------------------------------------- * 0
