T-cell epitope databases and algorithms

The most difficult problem in the study of T-Cells is to figure out

1. which peptides are displayed by the cell and
2. which T-Cell receptor binds to which peptide

Databases of peptides:

• HSPV: Big list of peptides derived from RefSeq and dbSNP, not annotated at all
• Ludwig CancerImmunomeDB: database of cDNA clones, some which annotated to react to serum

Algorithms to predict which peptides are displayed:

• SYFPEITHI - proprietory
• NetMHC - downloadable