Cryptochrome evolution: Difference between revisions

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[[IMAGE:CyrDASH.jpg|left]]
[[IMAGE:CyrDASH.jpg|left]]


Although originally found in plants, surprisingly it extends into fish, frogs, salamanders, turtle, lizard, finch, duck, and budgerigar. Using blastx on the syntenic region in gallinaceaous birds (chicken and turkey) establishes that they have highly degenerate pseudogenes at the expected location. It is not possible to date this more precisely nor determine whether pseudogenization occurred in a common ancestor or independently on account of domestication.
Although originally found in plants, surprisingly the DASH photolyase extends into fish, frogs, salamanders, turtle, lizard, finch, duck, and budgerigar. Using blastx on the syntenic region in gallinaceaous birds (chicken and turkey) establishes that they have a highly degenerate multi-exonic pseudogene at the expected location and orientation. It is not possible to date this more precisely nor determine whether pseudogenization occurred in a common ancestor or independently on account of domestication.  
 
Platypus does not have any pseudogene debris at the expected location but the assembly has a break here. Marsupials and placentals again appear never to have had this enzyme. The loss of this photoenzyme is very similar to the [Opsin_evolution:_trichromatic_ancestral_mammal|massive loss of opsins] that occured early in mammalian evolution -- which GT Walls in 1942 [[http://www.crsltd.com/research-topics/walls/index.html attributed]] to mammals experiencing a sustained period of deep nocturnality where these systems did not need to function (no UV damage) and indeed could not function (insufficient blue light) and so were lost.


Platypus does not have any pseudogene debris at the expected location but the assembly has a break here. Marsupials and placentals again appear never to have had this enzyme. The loss of this photoenzyme is very similar to the [Opsin_evolution:_trichromatic_ancestral_mammal|massive loss of opsins] that occured early in mammalian evolution -- which GT Walls in 1942 [[http://www.crsltd.com/research-topics/walls/index.html attributed]] to mammals experiencing a sustained period of deep nocturnality where these systems did not need to function (no UV damage) and indeed could not function (insufficient blue light) and so were lost (ie did not give rise to a non-catalytic cryptochrome of altered functionality). An analogous event may have occurred after the [http://en.wikipedia.org/wiki/Great_Oxygenation_Event great oxygenation event] gave rise to a stratospheric ozone protective layer at 2.4 byr but reached an even higher lever during the early Cambrian (based indirectly on oxygen levels). The first land plants and animals would have experienced greatly increased levels of UV damage however and that too may correlate with evolutionary events.
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  >DASH_taeGut Taeniopygia guttata (finch) ABQF01044665 ABQF01044669 ABQF01044671 synteny: ACAA1 DASH MYD66 OXSR1
  >DASH_taeGut Taeniopygia guttata (finch) ABQF01044665 ABQF01044669 ABQF01044671 synteny: ACAA1 DASH MYD66 OXSR1

Revision as of 15:01, 2 March 2012

Introduction to Cryptochromes

Cryptochromes are large flavoproteins with a curiously complex evolutionary history, beginning billions of years ago as repair enzymes for dna damaged by ultraviolet light. An old gene duplication followed by specializing divergence gave rise to two paralogs repairing distinct types of dna damage (cyclobutane pyrimidine dimers and 6-4 pyrimidine-pyrimidone pairs). These photolyases initially used FAD activated by visible blue light to undo the damage done by UV.

Since FAD has relatively low adsorbance, photolyases evolved a second site for an antenna chromophore with better light harvesting capabilities that could transfer its excitation to the FAD at the active site. This elusive second molecule may be FMN, folate, or a deazaflavin called Fo (once thought restrict to methanogenic archaea). In the case of the much-studied Drosophila, both the photolyases utilize Fo, making it a new vitamin for this species since the Fo biosynthetic genes are absent.

A second round of gene duplication of the 6-4 photolyase gave rise to a cryptochrome which retained the conformational change induced by FAD binding of blue light but lost dna repair capacity, instead specializing in entraining the day/night circadian rhythm cycle. A third round of gene duplication gave rise to two cryptochromes CRY1 and CRY2.

These four genes were retained in various combinations in different clades during the subsequent course of evolution, causing endless comparative genomic confusion. For example, Drosophila did not retain CRY2 unlike other insects and placental mammals lost both photolyases though marsupials retained one. Rayfinned fish had a series of further duplications within the gene family. Over all this, the fold, exon structure and FAD binding site were largely conserved, while antenna molecules and dna repair capacity were sometimes lost, even as altogether new binding properties developed giving some family members important new regulatory capacities.

(to be continued shortly)

Lab mouse has a mutated CRY1 gene

Lab mouse has an odd mutation in its 10th exon where a century of inbreeding may have inadvertently fixed a very serious 54 bp tandem stutter mutation resulting in 18 additional amino acids (the NGGLMGYAPGENVPSCSGG red and blue repeats in NM_007771 reference sequence) that would very likely disrupt the C-terminal region of the protein. The repeat is preceded by the substitution of a serine (shown in magenta in the alignment below) for a strictly invariant proline (back to chondrichthyes).

CRY1dotplot.png

Although this region lies beyond the two main domains and has a complex evolutionary history, phylogenetic comparison to the eight available rodent and lagomorph sequences implies that this change in lab mouse will have serious functional consequences. A mutation in this critical pacemaker gene could plausibly affect lifespan, metabolic disorder and tumor progression; such a change is completely unprecedented in rodents including rat and indeed in vertebrates.

All 14 available transcripts exhibit the same anomaly -- this is limited to one strain of mouse, nor a somatic mutation, nor an unfortunate heterozygous allele. The affected ESTs came from C57BL/6J, C57BL/6, C57BL/6J x DBA/2J, 129 FVB/N and embryo, eye, ventricle, thymus, mammary tumor; the affected GenBank NR entries add a keratinocyte cell line Pam. The mouse genome project used C57BL/6J, the most widely used inbred strain according to the Jackson Laboratory:

"Although C57BL/6J is refractory to many tumors, it is a permissive background for maximal expression of most mutations. C57BL/6J mice are resistant to audiogenic seizures, have a relatively low bone density, and develop age related hearing loss. They are also susceptible to diet-induced obesity, type 2 diabetes, and atherosclerosis. C57BL/6J mice are used in a wide variety of research areas including cardiovascular biology, developmental biology, diabetes and obesity, genetics, immunology, neurobiology, and sensorineural research. C57BL/6J mice are also commonly used in the production of transgenic mice. Overall, C57BL/6 mice breed well, are long-lived, and have a low susceptibility to tumors. Primitive hematopoietic stem cells from C57BL/6J mice show greatly delayed senescence relative to BALB/c and DBA/2J. This is a dominant trait. Other characteristics include: 1) a high susceptibility to diet-induced obesity, type 2 diabetes, and atherosclerosis; 2) a high incidence of microphthalmia and other associated eye abnormalities; 3) resistance to audiogenic seizures; 4) low bone density; 5) hereditary hydrocephalus (early reports indicate 1 - 4 %); 6) hairloss associated with overgrooming, 7) a preference for alcohol and morphine; 8) late-onset hearing loss; and 9) increased incidence of hydrocephalus and malocclusion."

Although this distal region is not modelled in any PDB structure as of March 2012, it has been specifically addressed in 4 of the 195 articles on mouse CRY1 or CRY2.

"purified mCRY1/2CCtail proteins form stable heterodimeric complexes with two C-terminal mBMAL1 fragments. The longer mBMAL1 fragment (BMAL490) includes Lys-537, which is rhythmically acetylated by mCLOCK in vivo. mCRY1 (but not mCRY2) has a lower affinity to BMAL490 than to the shorter mBMAL1 fragment (BMAL577) and a K537Q mutant version of BMAL490. Using peptide scan analysis we identify two mBMAL1 binding epitopes within the coiled coil RLNIERMKQIYQQLSRYR and tail regions of mCRY1/2 and document the importance of positively charged mCRY1 residues for mBMAL1 binding."

CRY1BMAL1.png

"mammalian CRY1 and CRY2 are integral components of the circadian oscillator. However, the function of their C terminus remains to be resolved. Here, we show that the C-terminal extension of mCRY1 harbors a nuclear localization signal and a putative coiled-coil domain that drive nuclear localization via two independent mechanisms and shift the equilibrium of shuttling mammalian CRY1 (mCRY1)/mammalian PER2 (mPER2) complexes towards the nucleus. Importantly, deletion of the complete C terminus prevents mCRY1 from repressing CLOCK/BMAL1-mediated transcription, whereas a plant photolyase gains this key clock function upon fusion to the last 100 amino acids of the mCRY1 core and its C terminus. Thus, the acquirement of different (species-specific) C termini during evolution not only functionally separated cryptochromes from photolyase but also caused diversity within the cryptochrome family."

"The mCRY1 and mCRY2 genes are located on chromosome 10C and 2E, respectively, and are expressed in all mouse organs examined. We raised antibodies specific against each gene product using its C-terminal sequence, which differs completely between the genes. Immunofluorescent staining of cultured mouse cells revealed that mCRY1 is localized in mitochondria whereas mCRY2 was found mainly in the nucleus. The subcellular distribution of CRY proteins was confirmed by immunoblot analysis of fractionated mouse liver cell extracts. Using green fluorescent protein fused peptides we showed that the C-terminal region of the mouse CRY2 protein contains a unique nuclear localization signal, which is absent in the CRY1 protein. The N-terminal region of CRY1 was shown to contain the mitochondrial transport signal. Recombinant as well as native CRY1 proteins from mouse and human cells showed a tight binding activity to DNA Sepharose, while CRY2 protein did not"

"genetic screening assay for mutant circadian clock proteins that is based on real-time circadian rhythm monitoring in cultured fibroblasts. By using this assay, we identified a domain in the extreme C terminus of BMAL1 that plays an essential role in the rhythmic control of E-box-mediated circadian transcription. Remarkably, the last 43 aa of BMAL1 are required for transcriptional activation, as well as for association with the circadian transcriptional repressor CRY1"

                     507       517       527       537       547        557       567        577       587       597
                       |         |         |         |         |          |         |          |         |         |
CRY1_musMus   GLLASVPSNSNGNGGLMGYAPGENVPSCSSSGNGGLMGYAPGENVPSCSGG NCSQGSGILHYAHGDSQQTHSLKQ GRSSAGTGLSSGKRPSQEEDAQSVGPKVQRQSSN*
CRY1_ratNor   GLLASVPSNPNGNGGLMGYAPGENVPSGGSGG------------------G NCSQGSGILHYAHGDSQQTNPLKQ GRSSMGTGLSSGKRPSQEEDAQSVGPKVQRQSSN*
CRY1_criGri   GLLASVPSNPNGNGGLMGYTTGENLPSCSGGG------------------- SCSQGSGILHYAHGDSQQAHLLKQ GRSSMGTSLSSGKRPSQEEETRSVDPKVQRQSSN*
CRY1_spaJud   GLLASVPSNPNGNGGLMGYTPGENIPNCSSSG------------------- SCSQGSGILHYAHGDSQQAHLLKQ GSSSMGHGLSNGKRPSQEEDTQSIGPKVQRQSTN*
CRY1_dipOrd   GLLASVPSNPNGNGGLMGYAAGDNLPGSSSSG------------------- SCSQGSGILHYAHGDSQQMHLLKQ GRSSMGTGLSSGKRPSQEEDSQSIGPKVQRQSTN*
CRY1_hetGla   GLLASVPSNPNGNGGLMGYAPGESIPGSSGSG------------------- SCAHGSGILPCAHTDGQQAHLLKP GRNCVGPVLSSGKRPSQEEDAQSIGPKLQRQSTD*
CRY1_cavPor   GLLASVPSNPNGNGGLLGYAPGESTPGSGGG-------------------- SCVPGSSSAGVSHCAQGEAPQAPP GRDPAGPGLGGGKRPSQEEDAQSTGHKIQRQSPD*
CRY1_speTri   GLLASVPSNPNGNGGLMAYAPGENIPGCSSSG------------------- SCTQGSSILHNAHGDSQQTHLLKQ GRSSMGTGLSSGKRPSQEEDTQSIGPKVQRQSTN*
CRY1_oryCun   GLLASVPSNPNGNGGLMGYSPGENIPGCSSSG------------------- SCSQGSGILHYAQGDTQQTQLLKQ GRSSMGTGLSSGKRPSQEEDTQSIGPKVQRQSTN*

CRY1_musMus   GLLASVPSNSNGNGGLMGYAPGENVPSCSSSGNGGLMGYAPGENVPSCSGG NCSQGSGILHYAHGDSQQTHSLKQ GRSSAGTGLSSGKRPSQEEDAQSVGPKVQRQSSN*
CRY1_ratNor   .........P.................GG.G.------------------. ...................NP... ....M.............................
CRY1_criGri   .........P.........TT...L....GG.------------------- S.................A.L... ....M..S...........ETR..D.........
CRY1_spaJud   .........P.........T....I.N.....------------------- S.................A.L... .S..M.H...N.........T..I........T.
CRY1_dipOrd   .........P..........A.D.L.GS....------------------- S.................M.L.... ...M...............S..I........T.
CRY1_hetGla   .........P.............SI.GS.G..------------------- S.AH.....PC..T.G..A.L..P. .NCV.PV...............I...L....TD
CRY1_cavPor   .........P......L......ST.GSGGG-------------------- S.VP..SSAGVS.CAQGEAPQAPP. .DP..P..GG............T.H.I....PD
CRY1_speTri   .........P.......A......I.G.....------------------- S.T...S...N.........L.... ...M...............T..I........T.
CRY1_oryCun   .........P.........S....I.G.....------------------- S...........Q..T...QL.... ...M...............T..I........T.

COILs coiled coil prediction for mouse CRY1 480-493 RLNIERMKQIYQQLSRYR
478 R	e 0.644
479 L	f 0.644 
480 N	g 0.806
481 I	a 0.806
482 E	b 0.806
483 R	c 0.806
484 M	d 0.806
485 K	e 0.806
486 Q	f 0.806 
487 I	g 0.806
488 Y	a 0.806
489 Q	b 0.806
490 Q	c 0.806
491 L	d 0.806
492 S	e 0.806
493 R	f 0.806 
494 Y	d 0.375
495 R	e 0.375 

>CRY1_musMus Mus musculus (mouse) NM_007771 all transcripts support longer exon 10 lost splice donor
1 RYLPVLRGFPAKYIYDPWNAPEGIQKVAKCLIGVNYPKPMVNHAEASRLNIERMKQIYQQLSRYRYRGL 1
2 GLLASVPSSNGNGGLMGYAPGENVPSCSSSGNGGLMGYAPGENVPSCSGG 1
2 NCSQGSGILHYAHGDSQQTHSLKQ 1
2 GRSSAGTGLSSGKRPSQEEDAQSVGPKVQRQSSN* 0

>CRY1_ratNor Rattus norvegicus (rat) NM_198750
1 RYLPVLRGFPAKYIYDPWNAPEGIQKVAKCLIGVNYPKPMVNHAEASRLNIERMKQIYQQLSRYRGL 1
2 GLLASVPSNPNGNGGLMGYAPGENVPSGGSGGG 1
2 NCSQGSGILHYAHGDSQQTNPLKQ 1
2 GRSSMGTGLSSGKRPSQEEDAQSVGPKVQRQSSN* 0

>CRY1_criGri Cricetulus griseus (hamster) XM_003505292
1 RYLPVLRGFPAKYIYDPWNAPEGIQKVAKCLIGVNYPKPMVNHAEASRLNIERMKQIYQQLSRYRGL 1
2 GLLASVPSNPNGNGGLMGYTTGENLPSCSGGG 1
2 SCSQGSGILHYAHGDSQQAHLLKQ 1
2 GRSSMGTSLSSGKRPSQEEETRSVDPKVQRQSSN* 0

>CRY1_spaJud Spalax judaei (blind mole rat) AJ606298
1 RYLPVLRGFPAKYIYDPWNAPEGIQKVAKCLIGVNYPKPMVNHAEASRLNIERMKQIYQQLSRYRGL 1
2 GLLASVPSNPNGNGGLMGYTPGENIPNCSSSG 1
2 SCSQGSGILHYAHGDSQQAHLLKQ 1
2 GSSSMGHGLSNGKRPSQEEDTQSIGPKVQRQSTN* 0

>CRY1_dipOrd Dipodomys ordii (kangaroo rat) ABRO01202522 ABRO01202521
1 RYLPVLRGFPAKYIYDPWNAPEGIQKVAKCLIGVNYPKPMVNHAEASRLNIERMKQIYQQLSRYRGL 1
2 GLLASVPSNPNGNGGLMGYAAGDNLPGSSSSG 1
2 SCSQGSGILHYAHGDSQQMHLLKQ 1
2 GRSSMGTGLSSGKRPSQEEDSQSIGPKVQRQSTN* 0

>CRY1_hetGla Heterocephalus glaber (mole-rat)
1 RYLPVLRGFPAKYIYDPWNAPEGIQKVAKCLIGVNYPKPMVNHAEASRLNIERMKQIYQQLSRYRGL 1
2 GLLASVPSNPNGNGGLMGYAPGESIPGSSGSG 1
2 SCAHGSGILPCAHTDGQQAHLLKP 1
2 GRNCVGPVLSSGKRPSQEEDAQSIGPKLQRQSTD* 0

>CRY1_cavPor Cavia porcellus (guinea pig) last two exons diverged
1 RYLPVLRGFPAKYIYDPWNAPEGIQKVAKCLIGVNYPKPMVHHAEASRLNIERMKQIYQQLSRYRGL 1
2 GLLASVPSNPNGNGGLLGYAPGESTPGSGGG 1
2 SCVPGSSSAGVSHCAQGEAPQAPP 1
2 GRDPAGPGLGGGKRPSQEEDAQSTGHKIQRQSPD* 0

>CRY1_speTri Spermophilus tridecemlineatus (squirrel) Ictidomys
1 RYLPVLRGFPAKYIYDPWNAPEGIQKVAKCLIGVNYPKPMVNHEASLNIERMKQIYQQLSRYRGL 1
2 GLLASVPSNPNGNGGLMAyAPGENIPGCSSSG 1
2 SCTQGSSILHNAHGDSQQTHLLKQ 1
2 GRSSMGTGLSSGKRPSQEEDTQSIGPKVQRQSTN* 0

>CRY1_oryCun Oryctolagus cuniculus (rabbit)
1 RYLPVLRGFPAKYIYDPWNAPEGIQKVAKCLIGINYPKPMVNHAEASRLNIERMKQIYQQLSRYRGL 1
2 GLLASVPSNPNGNGGLMGYSPGENIPGCSSSG 1
2 SCSQGSGILHYAQGDTQQTQLLKQ 1
2 GRSSMGTGLSSGKRPSQEEDTQSIGPKVQRQSTN* 0

>CRY1_ochPri Ochotona princeps (pika)
1  1
2  1
2 GCPQGSGILHCGHGDSQQTHLLKQ 1
2 GRGSPDTGISSGKRPSQEEDTQSIGPKVQRQSTN* 0

Vertebrate CRY1 reference sequences

>CRY1_homSap Homo sapiens (human)
0 MGVNAVHWFRKGLRLHDNPALKECIQGADTIRCVYILDPWFAGSSNVGINRWR 2
1 FLLQCLEDLDANLRKLNSRLFVIRGQPADVFPRLFK 0
0 EWNITKLSIEYDSEPFGKERDAAIKKLATEAGVEVIVRISHTLYDLDK 2
1 IIELNGGQPPLTYKRFQTLISKMEPLEIPVETITSEVIEKCTTPLSDDHDEKYGVPSLEEL 1
2 GFDTDGLSSAVWPGGETEALTRLERHLERK 0
0 AWVANFERPRMNANSLLASPTGLSPYLRFGCLSCRLFYFKLTDLYKK 0
0 VKKNSSPPLSLYGQLLWREFFYTAATNNPRFDKMEGNPICVQIPWDKNPEALAKWAEGRTGFPWIDAIMTQLRQEGWIHHLARHAVACFLTRGDLWISWEEGMK 0
0 VFEELLLDADWSINAGSWMWLSCSSFFQQFFHCYCPVGFGRRTDPNGDYIR 2
1 RYLPVLRGFPAKYIYDPWNAPEGIQKVAKCLIGVNYPKPMVNHAEASRLNIERMKQIYQQLSRYRGL 1
2 GLLASVPSNPNGNGGFMGYSAENIPGCSSSG 1
2 SCSQGSGILHYAHGDSQQTHLLKQ 1
2 GRSSMGTGLSGGKRPSQEEDTQSIGPKVQRQSTN* 0

>CRY1_panTro Pan troglodytes (chimpanzee) XM_509339
0 MGVNAVHWFRKGLRLHDNPALKECIQGADTIRCVYILDPWFAGSSNVGINRWR 2
1 FLLQCLEDLDANLRKLNSRLFVIRGQPADVFPRLFK 0
0 EWNITKLSIEYDSEPFGKERDAAIKKLATEAGVEVIVRISHTLYDLDK 2
1 IIELNGGQPPLTYKRFQTLISKMEPLEIPVETITSEVIEKCTTPLSDDHDEKYGVPSLEEL 1
2 GFDTDGLSSAVWPGGETEALTRLERHLERK 0
0 AWVANFERPRMNANSLLASPTGLSPYLRFGCLSCRLFYFKLTDLYKK 0
0 VKKNSSPPLSLYGQLLWREFFYTAATNNPRFDKMEGNPICVQIPWDKNPEALAKWAEGRTGFPWIDAIMTQLRQEGWIHHLARHAVACFLTRGDLWISWEEGMK 0
0 VFEELLLDADWSINAGSWMWLSCSSFFQQFFHCYCPVGFGRRTDPNGDYIR 2
1 RYLPVLRGFPAKYIYDPWNAPEGIQKVAKCLIGVNYPKPMVNHAEASRLNIERMKQIYQQLSRYRGL 1
2 GLLASVPSNPNGNGGFMGYSAENIPGCSSSG 1
2 SCSQGSGILHYAHGDSQQTHLLKQ 1
2 GRSSVGTGLSGGKRPSQEEDTQSIGPKVQRQSTN* 0

>CRY1_ponAbe Pongo abelii (Sumatran orangutan) XM_002823690
0 MGVNAVHWFRKGLRLHDNPALKECIQGADTIRCVYILDPWFAGSSNVGINRWR 2
1 FLLQCLEDLDASLRKLNSRLFVIRGQPADVFPRLFK 0
0 EWNITKLSIEYDSEPFGKERDAAIKKLATEAGVEVIVRISHTLYDLDK 2
1 IIELNGGQPPLTYKRFQTLISKMEPLEIPVETITSEVIEKCTTPLSDDHDEKYGVPSLEEL 1
2 GFDTDGLSSAVWPGGETEALTRLERHLERK 0
0 AWVANFERPRMNANSLLASPTGLSPYLRFGCLSCRLFYFKLTDLYKK 0
0 VKKNSSPPLSLYGQLLWREFFYTAATNNPRFDKMEGNPICVQIPWDKNPEALAKWAEGRTGFPWIDAIMTQLRQEGWIHHLARHAVACFLTRGDLWISWEEGMK 0
0 VFEELLLDADWSINAGSWMWLSCSSFFQQFFHCYCPVGFGRRTDPNGDYIR 2
1 RYLPVLRGFPAKYIYDPWNAPEGIQKVAKCLIGVNYPKPMVNHAEASRLNIERMKQIYQQLSRYRGL 1
2 GLLASVPSNPNGNGGFMGYSAENVPGCSSSG 1
2 SCSQGSGILHYAHGDSQQTHLLKQ 1
2 GRSSMGTGLSGGKRASQEEDTQSIGPKVQRQSTN* 0

>CRY1_nomLeu Nomascus leucogenys (gibbon) XM_003269977
0 MGVNAVHWFRKGLRLHDNPALKECIQGADTIRCVYILDPWFAGSSNVGINRWR 2
1 FLLQCLEDLDANLRKLNSRLFVIRGQPADVFPRLFK 0
0 EWNITKLSIEYDSEPFGKERDAAIKKLATEAGVEVIVRISHTLYDLDK 2
1 IIELNGGQPPLTYKRFQTLISKMEPLEIPVETITSEVIEKCTTPLSDDHDEKYGVPSLEEL 1
2 GFDTDGLSSAVWPGGETEALTRLERHLERK 0
0 AWVANFERPRMNANSLLASPTGLSPYLRFGCLSCRLFYFKLTDLYKK 0
0 VKKNSSPPLSLYGQLLWREFFYTAATNNPRFDKMEGNPICVQIPWDKNPEALAKWAEGRTGFPWIDAIMTQLRQEGWIHHLARHAVACFLTRGDLWISWEEGMK 0
0 VFEELLLDADWSINAGSWMWLSCSSFFQQFFHCYCPVGFGRRTDPNGDYIR 2
1 RYLPVLRGFPAKYIYDPWNAPEGIQKVAKCLIGVNYPKPMVNHAEASRLNIERMKQIYQQLSRYRGL 1
2 GLLASVPSNPNGNGGFMGYSAENIPGCSSSG 1
2 SCSQGSGILHYAHGDSQQTHLLKQ 1
2 GRSSMGTGLSGGKRPSQEEDTQSIGPKVQRQSTN* 0

>CRY1_macMul Macaca mulatta (rhesus) NM_001194159
0 MGVNAVHWFRKGLRLHDNPALKECIQGADTIRCVYILDPWFAGSSNVGINRWR 2
1 FLLQCLEDLDANLRKLNSRLFVIRGQPADVFPRLFK 0
0 EWNITKLSIEYDSEPFGKERDAAIKKLATEAGVEVIVRISHTLYDLDK 2
1 IIELNGGQPPLTYKRFQTLISKMEPLEIPVETITSEVIEKCTTPLSDDHDEKYGVPSLEEL 1
2 GFDTDGLSSAVWPGGETEALTRLERHLERK 0
0 AWVANFERPRMNANSLLASPTGLSPYLRFGCLSCRLFYFKLTDLYKK 0
0 VKKNSSPPLSLYGQLLWREFFYTAATNNPRFDKMEGNPICVQIPWDKNPEALAKWAEGRTGFPWIDAIMTQLRQEGWIHHLARHAVACFLTRGDLWISWEEGMK 0
0 VFEELLLDADWSINAGSWMWLSCSSFFQQFFHCYCPVGFGRRTDPNGDYIR 2
1 RYLPVLRGFPAKYIYDPWNAPEGIQKVAKCLIGINYPKPMVNHAEASRLNIERMKQIYQQLSRYRGL 1
2 GLLASVPSNPNGNGGFMGYSTENIPGCSSSGS 1
2 CSQGSGILHYTHGDSQQTHLLKQ 1
2 GRSSMGTGLSGGKRPSQEEDTQSIGPKVQRQSTN* 0

>CRY1_calJac Callithrix jacchus (marmoset) XM_002752946
0 MGVNAVHWFRKGLRLHDNPALKECIQGADTIRCVYILDPWFAGSSNVGINRWR 2
1 FLLQCLEDLDANLRKLNSRLFVIRGQPADVFPRLFK 0
0 EWNITKLSIEYDSEPFGKERDAAIKKLATEAGVEVIVRISHTLYDLDK 2
1 IIELNGGQPPLTYKRFQTLISKMEPLEIPVETITSEVIEKCTTPLSDDHDEKYGVPSLEEL 1
2 GFDTDGLSSAVWPGGETEALTRLERHLERK 0
0 AWVANFERPRMNANSLLASPTGLSPYLRFGCLSCRLFYFKLTDLYKK 0
0 VKKNSSPPLSLYGQLLWREFFYTAATNNPRFDKMEGNPICVQIPWDKNPEALAKWAEGRTGFPWIDAIMTQLRQEGWIHHLARHAVACFLTRGDLWISWEEGMK 0
0 VFEELLLDADWSINAGSWMWLSCSSFFQQFFHCYCPVGFGRRTDPNGDYIR 2
1 RYLPVLRGFPAKYIYDPWNAPEGIQKVAKCLIGVNYPKPMVNHAEASRLNIERMKQIYQQLSRYRGL 1
2 GLLASVPSNPNGNGGFMGYSAENIPGCTSSG 1
2 SCSQGSGILHCAHGDSQQTHLLKQ 1
2 GRSSMSTGISGGKRPSQEEDTQSIGPKVQRQSTN* 0

>CRY1_saiBol Saimiri boliviensis (squirrel monkey) nearly identical to marmoset
0 MGVNAVHWFRKGLRLHDNPALKECIQGADTIRCVYILDPWFAGSSNVGINRWR 2
1 FLLQCLEDLDANLRKLNSRLFVIRGQPADVFPRLFK 0
0 EWNITKLSIEYDSEPFGKERDAAIKKLATEAGVEVIVRISHTLYDLDK 2
1 IIELNGGQPPLTYKRFQTLISKMEPLEIPVETITSEVIEKCTTPLSDDHDEKYGVPSLEEL 1
2 GFDTDGLSSAVWPGGETEALTRLERHLERK 0
0 AWVANFERPRMNANSLLASPTGLSPYLRFGCLSCRLFYFKLTDLYKK 0
0 VKKNSSPPLSLYGQLLWREFFYTAATNNPRFDKMEGNPICVQIPWDKNPEALAKWAEGRTGFPWIDAIMTQLRQEGWIHHLARHAVACFLTRGDLWISWEEGMK 0
0 VFEELLLDADWSINAGSWMWLSCSSFFQQFFHCYCPVGFGRRTDPNGDYIR 2
1 RYLPVLRGFPAKYIYDPWNAPEGIQKVAKCLIGVNYPKPMVNHAEASRLNIERMKQIYQQLSRYRGL 1
2 GLLASVPSNPNGNGGFMGYSAENIPGCTSSG 1
2 SCSQGSGILHCAHGDSQQTHLLKQ 1
2 GRSSMSTGLGGGKRPSQEEDTQSIGPKVQRQSTN* 0

>CRY1_tarSyr Tarsius syrichta (tarsier) ABRT010205577 unsure if exon 2 is CRY1 or CRY2
0 2
1 FLLQSLEDLDTSLRKLNSRLFVVRGQPADVFPRLFK 0
0 EWNIAKLSIEYDSEPFGKERDAAIKKLATEAGVEVIVRISHTLYDLDK 0
0 IIELNGGQPPLTYKRFQTLISKMEPLEIPVETITSEVIEKCTTPLSDDHDEKYGVPSLEEL 1
2 GFDTDGLSSAVWPGGETEALTRLERHLERK 0
0 AWVANFERPRMNANSLLASPTGLSPYLRFGCLSCRLFYFKLTDLYKK 0
0 VKKNSSPPLSLYGQLLWREFFYTAATNNPRFDKMEGNPICVQIPWDKNPEALAKWAEGRTGFPWIDAIMTQLRQEGWIHHLARHAVACFLTRGDLWISWEEGMK 0
0 VFEELLLDADWSINAGSWMWLSCSSFFQQFFHCYCPVGFGRRTDPNGDYIR 2
1 RYLPVLRGFPAKYIYDPWNAPEGIQKVAKCLIGVNYPKPMVNHAEASRLNIERMKQIYQQLSRYRGL 1
2 GLLASVPSNPNGNGGFMGYSPAENTPGCSSSG 1
2 SCSQGSGILHYAHGDSQQTHLLKQ 1
2 GRSSVGTGLSGGKRPSQEEDPQSIGPKVQRQSTN* 0

>CRY1_micMur Microcebus murinus (mouse lemur) 
0 MGVNAVHWFRKGLRLHDNPALKECIQGADTIRCVYILDPWFAGSSNVGINRWR 2
1 FLLQCLEDLDANLRKLNSRLFVIRGQPADVFPRLFK 0
0 IIELNGGQPPLTYKRFQTLISK SEVIEKCTTPLSDD    1
2 GFDTDGLSSAVWPGGETEALTRLERHLERK 0
0 AWVANFERPRMNANSLLASPTGLSPYLRFGCLSCRLFYFKLTDLYKK 0
0 VKSSPPLSLYGRYLPVLRGFPAKYIYDPWNAPEGIQKVAKCLIGVNYPKPMVNHAEASRLNIERMKQIYQQLSRYRGL 1
1 RYLPVLRGFPAKYIYDPWNAPEGIQKVAKCLIGVNYPKPMVNHAEASRLNIERMKQIYQQLSRYRGL 1
2 GLLASVPSNPNGNGGFMEYSPAENIPGCSSSG 1
2 NCSQGSGILHYAHGDSQQTHLLKQ 1
2 GRSSMGTGFSGGKRPSQEEDTQSIGSKVQRQSTN* 0

>CRY1_otoGar Otolemur garnettii (bushbaby) AAQR03016495
0 MGVNAVHWFRKGLRLHDNPALKECIQGADTIRCVYILDPWFAGSSNVGINRWR 2
1 FLLQCLEDLDANLRKLNSRLFVIRGQPADVFPRLFK 0
0 EWNITRLSIEYDSEPFGKERDAAIKKLATEAGVEVIVRISHTLYDLDK 0
0 IIELNGGQPPLTYKRFQTLISKMEPLEIPVETITSEIIEKCTTPLFDDHDEKYGVPSLEEL 1
2 AWVANFERPRMNANSLLASPTGLSPYLRFGCLSCRLFYFKLTDLYKK 0
0 VKKNSSPPLSLYGQLLWREFFYTAATNNPRFDKMEGNPICVQIPWDKNPEALAKWAEGRTGFPWIDAIMTQLRQEGWIHHLARHAVACFLTRGDLWISWEEGMK 0
0 VFEELLLDADWSINAGSWMWLSCSSFFQQFFHCYCPASFGRRTDPNGDYIR 2
1 RYLPVLRGFPAKYIYDPWNAPEGIQKVAKCLIGINYPKPMVNHAEASRLNIERMKQIYQQLSRYRGL 1
2 GLLASVPSNPNGNGSFMEYSPPENIPGCSSSG 1
2 NCSQGSGILHYAPGDGQQPHLLKQ 1
2 GRSSMGTGLSGGKRPSQEEDMQSVGPKVQRQSTN* 0

>CRY1_tupBel Tupaia belangeri (treeshrew)
0 2
1 FLLQCLEDLDANLRKLNSRLFVIRGQPADVFPRLFK 0
0 EWNITKLSIEYDSEPFGKERDAAIKKLATEAGVEVIVRISHTLYDLDK 0
0 IIELNGGQPPLTYKRFQTLISKMEPLEIPVETITSEVIEKCTTPLSDDHDEKFGVPSLEEL 1
2 GFDTDGLSSAVWPGGETEALTRLERHLERK 0
0 AWVANFERPRVNSNSLLASPTGL
0 VFEELLLDADWSINAGSWMWLSCSSFFQQFFHCYCPVGFGRRTDPNGDYIR 2
1 RYLSSSGSCSQGSGILHYAHGDSQQTHLLKQGRSSMGP      1
2  1
2 GCSQGSGILHYAHGDSQQTHLLKQ  1
2 GLSSGKRPSQEEDTQSIGPKVQRQSTN* 0


>CRY1_musMus Mus musculus (mouse) NM_007771 all transcripts support longer exon 10 lost splice donor
0 MGVNAVHWFRKGLRLHDNPALKECIQGADTIRCVYILDPWFAGSSNVGINRWR 2
1 FLLQCLEDLDANLRKLNSRLFVIRGQPADVFPRLFK 0
0 EWNITKLSIEYDSEPFGKERDAAIKKLATEAGVEVIVRISHTLYDLDK 2
1 IIELNGGQPPLTYKRFQTLVSKMEPLEMPADTITSDVIGKCMTPLSDDHDEKYGVPSLEEL 1
2 GFDTDGLSSAVWPGGETEALTRLERHLER 0
0 KAWVANFERPRMNANSLLASPTGLSPYLRFGCLSCRLFYFKLTDLYKK 0
0 VKKNSSPPLSLYGQLLWREFFYTAATNNPRFDKMEGNPICVQIPWDKNPEALAKWAEGRTGFPWIDAIMTQLRQEGWIHHLARHAVACFLTRGDLWISWEEGMK 0
0 VFEELLLDADWSINAGSWMWLSCSSFFQQFFHCYCPVGFGRRTDPNGDYIR 2
1 RYLPVLRGFPAKYIYDPWNAPEGIQKVAKCLIGVNYPKPMVNHAEASRLNIERMKQIYQQLSRYRGL 1
2 GLLASVPSNSNGNGGLMGYAPGENVPSCSSSGNGGLMGYAPGENVPSCSGG 1
2 NCSQGSGILHYAHGDSQQTHSLKQ 1
2 GRSSAGTGLSSGKRPSQEEDAQSVGPKVQRQSSN* 0

>CRY1_ratNor Rattus norvegicus (rat) NM_198750
0 MGVNAVHWFRKGLRLHDNPALKECIQGADTIRCVYILDPWFAGSSNVGINRWR 2
1 FLLQCLEDLDANLRKLNSRLFVIRGQPADVFPRLFK 0
0 EWNITKLSIEYDSEPFGKERDAAIKKLATEAGVEVIVRISHTLYDLDK 2
1 IIELNGGQPPLTYKRFQTLVSKMEPLEMPADTITSDVIGKCTTPLSDDHDEKYGVPSLEEL 1
2 GFDTDGLSSAVWPGGETEALTRLERHLERK 0
0 AWVANFERPRMNANSLLASPTGLSPYLRFGCLSCRLFYFKLTDLYKK 0
0 VKKNSSPPLSLYGQLLWREFFYTAATNNPRFDKMEGNPICVQIPWDKNPEALAKWAEGRTGFPWIDAIMTQLRQEGWIHHLARHAVACFLTRGDLWISWEEGMK 0
0 VFEELLLDADWSINAGSWMWLSCSSFFQQFFHCYCPVGFGRRTDPNGDYIR 2
1 RYLPVLRGFPAKYIYDPWNAPEGIQKVAKCLIGVNYPKPMVNHAEASRLNIERMKQIYQQLSRYRGL 1
2 GLLASVPSNPNGNGGLMGYAPGENVPSGGSGGG 1
2 NCSQGSGILHYAHGDSQQTNPLKQ 1
2 GRSSMGTGLSSGKRPSQEEDAQSVGPKVQRQSSN* 0

>CRY1_criGri Cricetulus griseus (hamster) XM_003505292
0 MGVNAVHWFRKglrlhDNPALKECIQGADTIRCVYILDPWFAGSSNVGINRWR 2
1 FLLQCLEDLDSNLRKLNSRLFVIRGQPADVFPRLFK 0
0 EWNITKLSIEYDSEPFGKERDAAIKKLATEAGVEVIVRISHTLYDLDK 2
1 IIELNGGQPPLTYKRFQTLVSKMEPLEMPAETITSDVIGKCMTPLSDDHDEKYGVPSLEEL 1
2 GFDTDGLSSAVWPGGETEALTRLERHLER 0
0 KAWVANFERPRMNANSLLASPTGLSPYLRFGCLSCRLFYFKLTDLYKK 0
0 VKKNSSPPLSLYGQLLWREFFYTAATNNPRFDKMEGNPICVQIPWDKNPEALAKWAEGRTGFPWIDAIMTQLRQEGWIHHLARHAVACFLTRGDLWISWEEGMK 0
0 VFEELLLDADWSINAGSWMWLSCSSFFQQFFHCYCPVGFGRRTDPNGDYIR 2
1 RYLPVLRGFPAKYIYDPWNAPEGIQKVAKCLIGVNYPKPMVNHAEASRLNIERMKQIYQQLSRYRGL 1
2 GLLASVPSNPNGNGGLMGYTTGENLPSCSGGG 1
2 SCSQGSGILHYAHGDSQQAHLLKQ 1
2 GRSSMGTSLSSGKRPSQEEETRSVDPKVQRQSSN* 0

>CRY1_spaJud Spalax judaei (blind mole rat) AJ606298
0 MGVNAVHWFRKGLRLHDNPALKECIQGADTIRCVYILDPWFAGSSNVGINRW 2
1 RFLLQCLEDLDANLRKLNSRLLVIRGQPADVFPRLFKEWNITKLSIEYDSEPFGKERDAAIKKLATEAGVEVIVRISHTLYDLDK 2
1 IIELNGGQPPLTYKRFQTLISKMEPLEIPVETITSEVIEKCTTPLSDDHDEKYGVPSLEEL 1
2 GFDTDGLSSAVWPGGETEALTRLERHLERR 0
0 AWVANFERPRMNANSLLASPTGLSPYLRFGCLSCRLFYFKLTDLYKK 0
0 VKKNSSPPLSLYGQLLWREFFYTAATNNPRFDKMEGNPICVQIPWDKNPEALAKWAEGRTGFPWIDAIMTQLRQEGWIHHLARHAVACFLTGSDLWISWEEGMK 0
0 VFEELLLDADWSINAGSWMWLSCSSFFQQFFHCYCPVGFGRRTDPNGDYIR 2
1 RYLPVLRGFPAKYIYDPWNAPEGIQKVAKCLIGVNYPKPMVNHAEASRLNIERMKQIYQQLSRYRGL 1
2 GLLASVPSNPNGNGGLMGYTPGENIPNCSSSG 1
2 SCSQGSGILHYAHGDSQQAHLLKQ 1
2 GSSSMGHGLSNGKRPSQEEDTQSIGPKVQRQSTN* 0

>CRY1_dipOrd Dipodomys ordii (kangaroo rat) ABRO01202522 ABRO01202521
0 MGVNAVHWFRKGLRLHDNPALKECIQGADTIRCVYILDPWFAGSSNVGINRW 2
1 RFLLQCLEDLDANLRKLNSRLFVIRGQPADVFPRLFK 0
0 EWNITKLSIEYDSEPFGKERDAAIKKLATEAGVEVIVRISHTLYDLDK 2
1 IIELNGGQPPLTYKRFQTLISKMEPLEIPVETITSEVIEKCTTPLSDDHDEKYGVPSLEEL 1
2 GFDTDGLSSAVWPGGETEALTRLERHLERK 0
0 AWVANFERPRMNANSLLASPTGLSPYLRFGCLSCRLFYFKLTDLYKK 0
0 VKKNSSPPLSLYGQLLWREFFYTAATNNPRFDKMEGNPICVQIPWDKNPEALAKWAEGRTGFPWIDAIMTQLRQEGWIHHLARHAVACFLTRGDLWISWEEGMK 0
0 VFEELLLDADWSINAGSWMWLSCSSFFQQFFHCYCSVGFGRRTDPNGDYIR 2
1 RYLPVLRGFPAKYIYDPWNAPEGIQKVAKCLIGVNYPKPMVNHAEASRLNIERMKQIYQQLSRYRGL 1
2 GLLASVPSNPNGNGGLMGYAAGDNLPGSSSSG 1
2 SCSQGSGILHYAHGDSQQMHLLKQ 1
2 GRSSMGTGLSSGKRPSQEEDSQSIGPKVQRQSTN* 0

>CRY1_speTri Spermophilus tridecemlineatus (squirrel) Ictidomys
0  2
1  
0    RDAAIKKLATEAGVEVIVRISHTLYDLDK 2
1 IIELNGGQPPLTYKRFQTLISKMEPLEIPVETITSEVIEKCTTPLSDDHDEKYGVPSLEEL 1
2 GFDTDGLSSAVWPGGETEALTRLERHLERK 0
0 AWVANFERPRMNANSLLASPTGLSPYLRFGCLSCRLFYFKLTDLYKK 0
0 VKKNSSPPLSLYGQLLWREFFYTAATNNPRFDKMEGNPICVQIPWDKNPEALAKWAEGRTGFPWIDAIMTQLRQEGWIHHLARHAVACFLTRGDLWISWEEGMK 0
0 VFEELLLDADWSINAGSWMWLSCSSFFQQFFHCYCPVGFGRRTDPNGDYIR 2
1 RYLPVLRGFPAKYIYDPWNAPEGIQKVAKCLIGVNYPKPMVNHEASLNIERMKQIYQQLSRYRGL 1
2 GLLASVPSNPNGNGGLMAyAPGENIPGCSSSG 1
2 SCTQGSSILHNAHGDSQQTHLLKQ 1
2 GRSSMGTGLSSGKRPSQEEDTQSIGPKVQRQSTN* 0

>CRY1_oryCun Oryctolagus cuniculus (rabbit)
0 MGVNAVHWFRKGLRLHDNPALKECIQGADTIRCVYILDPWFAGSSNVGINRW 2
1 RFLLQCLEDLDANLRKLNSRLFVIRGQPADVFPRLFK 0
0 EWNITRLSIEYDSEPFGKERDAAIKKLASEAGVEVIVRISHTLYDLDK 2
1 IIELNGGQPPLTYKRFQTLISKMEPLEIPVETITSDVIEKCTTPVSDDHDEKYGVPSLEEL 1
2 GFDTDGLSSAVWPGGETEALTRLERHLERK 0
0 AWVANFERPRMNANSLLASPTGLSPYLRFGCLSCRLFYFKLTDLYKK 0
0 VKKNSSPPLSLYGQLLWREFFYTAATNNPRFDKMEGNPICVQIPWDKNPEALAKWAEGQTGFPWIDAIMTQLRQEGWIHHLARHAVACFLTRGDLWISWEEGMK 0
0 VFEELLLDADWSINAGSWMWLSCSSFFQQFFHCYCPVGFGRRTDPNGDYIR 2
1 RYLPVLRGFPAKYIYDPWNAPEGIQKVAKCLIGINYPKPMVNHAEASRLNIERMKQIYQQLSRYRGL 1
2 GLLASVPSNPNGNGGLMGYSPGENIPGCSSSG 1
2 SCSQGSGILHYAQGDTQQTQLLKQ 1
2 GRSSMGTGLSSGKRPSQEEDTQSIGPKVQRQSTN* 0

>CRY1_ochPri Ochotona princeps (pika)
0  2
1  0
0 EWNITKLSIEYDSEPFGKERDAAIKKLATEAGVEVIVRISHTLYDLDK 2
1  1
2 GFDTDGLSSAVWPGGETEALTRLERHLERK 0
0 AWVANFERPRMNANSLLASPTGLSPYLRFGCLSCRLFYFKLTDLYKK 0
0 VKKNSSPPLSLYGQLLWREFFYTAATNNPRFDKMEGNPICVQIPWDKNPEALAKWAEGRTGFPWIDAIMTQLRQEGWIHHLARHAVACFLTRGDLWISWEEGMK 0
0  2
1  1
2  1
2 GCPQGSGILHCGHGDSQQTHLLKQ 1
2 GRGSPDTGISSGKRPSQEEDTQSIGPKVQRQSTN* 0


>CRY1_oviAri Ovis aries (sheep) NM_001129735 19341811 19150926
0 MGVNAVHWFRKGLRLHDNPALKECIQGADTIRCVYILDPWFAGSSNVGINRWR 2
1 FLLQCLEDLDANLRKLNSRLFVIRGQPADVFPRLFK 0
0 EWNITKLSIEYDSEPFGKERDAAIKKLATEAGVEVIIRISHTLYDLDK 2
1 IIELNGGQPPLTYKRFQTLISKMEPLEIPVETITSEVMEKCTTPLSDDHDEKYGVPSLEEL 1
2 GFDTDGLPSAVWPGGETEALTRLERHLERK 0
0 AWVANFERPRMNANSLLASPTGLSPYLRFGCLSCRLFYFKLTDLYKK 0
0 VKKNSSPPLSLYGQLLWREFFYTAATNNPRFDKMEGNPICVQIPWDKNPEALAKWAEGRTGFPWIDAIMTQLRQEGWIHHLARHAVACFLTRGDLWISWEEGMK 0
0 VFEELLLDADWSINAGSWMWLSCSSFFQQFFHCYCPVGFGRRTDPNGDYIR 2
1 RYLPVLRGFPAKYIYDPWNAPEGIQKVAKCLIGVNYPKPMVNHAEASRLNIERMKQIYQQLSRYRG 1
2 GLLASVPSNPNGNGGLMGYSPGENIPGCSSSA 1
2 SCTQGSGILHYAHGDSQQTHLLKQ 1
2 GRSSTAAGLGSGKRPSQEEDTQSVGPKVQRQSTN* 0

>CRY1_bosTau Bos taurus (cattle) NM_001105415 XM_616063
0 MGVNAVHWFRKGLRLHDNPALKECIQGADTIRCVYILDPWFAGSSNVGINRWR 2
1 FLLQCLEDLDANLRKLNSRLFVIRGQPADVFPRLFK 0
0 EWNITKLSIEYDSEPFGKERDAAIKKLATEAGVEVIVRISHTLYDLDK 2
1 IIELNGGQPPLTYKRFQTLISKMEPLEIPVETITSEVIEKCTTPLSDDHDEKYGVPSLEEL 1
2 GFDTDGLPSAVWPGGETEALTRLERHLERK 0
0 AWVANFERPRMNANSLLASPTGLSPYLRFGCLSCRLFYFKLTDLYKK 0
0 VKKNSSPPLSLYGQLLWREFFYTAATNNPRFDKMEGNPICVQIPWDKNPEALAKWAEGRTGFPWIDAIMTQLRQEGWIHHLARHAVACFLTRGDLWISWEEGMK 0
0 VFEELLLDADWSINAGSWMWLSCSSFFQQFFHCYCPVGFGRRTDPNGDYIR 2
1 RYLPVLRGFPAKYIYDPWNAPEGIQKVAKCLIGVNYPKPMVNHAEASRLNIERMKQIYQQLSRYRGL 1
2 GLLASVPSNPNGNGGLMGYSPGENIPGCSSNA 1
2 SCTQGSGILHYAHGDSQQTHLLKQ 1
2 GRSSTGAGLGSGKRPSQEEDTQSIGPKVQRQSTN* 0
+
>CRY1_susScr Sus scrofa (pig) XM_003126079
0 MGVNAVHWFRKGLRLHDNPALKECIQGADTIRCVYILDPWFAGSSNVGINRWR 2
1 FLLQCLEDLDANLRKLNSRLFVIRGQPADVFPRLFK 0
0 EWNITKLSIEYDSEPFGKERDAAIKKLATEAGVEVIVRISHTLYDLDK 2
1 IIELNGGQPPLTYKRFQTLISKMEPLEIPVETITSEVIEKCTTPLSDDHDEKYGVPSLEEL 1
2 GFDTDGLPSAVWPGGETEALTRLERHLERK 0
0 AWVANFERPRMNANSLLASPTGLSPYLRFGCLSCRLFYFKLTDLYKK 0
0 VKKNSSPPLSLYGQLLWREFFYTAATNNPRFDKMEGNPICVQIPWDKNPEALAKWAEGRTGFPWIDAIMTQLRQEGWIHHLARHAVACFLTRGDLWISWEEGMK 0
0 VFEELLLDADWSINAGSWMWLSCSSFFQQFFHCYCPVGFGRRTDPNGDYIR 2
1 RYLPVLRGFPAKYIYDPWNAPEGIQKVAKCLIGVNYPKPMVNHAEASRLNIERMKQIYQQLSRYRGL 1
2 GLLASVPSNPNGNGGLMGYSPGENIPGCSSSG 1
2 SCPQGSGILHYAHGESQQNHLLKQ 1
2 GRSSTGSGLSSAKRPSQEEDTQSIIGPKVQRQSTN* 0

>CRY1_ailMel Ailuropoda melanoleuca (panda) XM_002927658
0 MGVNAVHWFRKGLRLHDNPALKECIQGADTIRCVYILDPWFAGSSNVGINRWR 2
1 FLLQCLEDLDANLRKLNSRLFVIRGQPADVFPRLFK 0
0 EWNITKLSIEYDSEPFGKERDAAIKKLATEAGVEVIVRISHTLYDLDK 2
1 IIELNGGQPPLTYKRFQTLISKMEPLEIPVETITSEVIEKCTTPLSDDHDEKYGVPSLEEL 1
2 GFDTDGLPSAVWPGGETEALTRLERHLERK 0
0 AWVANFERPRMNANSLLASPTGLSPYLRFGCLSCRLFYFKLTDLYKK 0
0 VKKNSSPPLSLYGQLLWREFFYTAATNNPRFDKMEGNPICVQIPWDKNPEALAKWAEGRTGFPWIDAIMTQLRQEGWIHHLARHAVACFLTRGDLWISWEEGMK 0
0 VFEELLLDADWSINAGSWMWLSCSSFFQQFFHCYCPVGFGRRTDPNGDYIR 2
1 RYLPVLRGFPAKYIYDPWNAPEGIQKVAKCLIGVNYPKPMVNHAEASRLNIERMKQIYQQLSRYRGL 1
2 GLLASVPANPNGNGGLMGYSPGENIPGCSSSG 1
2 SCSQGSGILHYAHGDSQQTHLLKQ 1
2 GRSSMGSGLSSGKRPSEEEDTQSIGPKVQRQSTN* 0


>CRY1_loxAfr Loxodonta africana (elephant) XM_003405313
0 MGVNAVHWFRKGLRLHDNPALKECIQGADTIRCVYILDPWFAGSSNVGINRWR 2
1 FLLQCLEDLDANLRKLNSRLFVIRGQPADVFPRLFK 0
0 EWDITKLSIEYDSEPFGKERDAAIKKLATEAGVEVIVRISHTLYDLDK 2
1 IIELNGGQPPLTYKRFQTLISKMEPLEIPVETITSEVIGKCTTPLSDDHDEKYGVPSLEEL 1
2 GFDTDGLPSAVWPGGETEALTRLERHLERK 0
0 AWVANFERPRMNANSLLASPTGLSPYLRFGCLSCRLFYFKLTDLYKK 0
0 VKKNSSPPLSLYGQLLWREFFYTAATNNPRFDKMEGNPICVQIPWDKNPEALAKWAEGRTGFPWIDAIMTQLRQEGWIHHLARHAVACFLTRGDLWISWEEGMK 0
0 VFEELLLDADWSINAGSWMWLSCSSFFQQFFHCYCPVGFGRRTDPNGDYIR 2
1 RYLPVLRGFPAKYIYDPWNAPEGIQKVAKCLIGVNYPKPMVNHAEASRLNIERMKQIYQQLSRYRGL 1
2 GLLASVPSNPNGNGGLMGYSPGENTPGCNSSG 1
2 SCSQGSGILHYVHGDSLLKQ 1
2 GRSPTGTGVSSGKRPSQDEETQTLGPKVQRQSTN* 0

>CRY1_monDom Monodelphis domestica (opossum) XM_003341966
0 MGVNAGHWFRKRLRLPHNPALKGCIQGADTVCCVYIRDPWFGGSSNFGANEWK 2
1 FLLQCLEDLDANLRKLNSRLFVIRGQPADVFPRLFK 0
0 EWNIAKLSIEYDSEPFGKERDAAIKKLASEAGVEVIVRISHTLYDLDK 0
0 IIELNGGQPPLTYKRFQTLISKMEPLATPVETITPEVMHKCVTPLSDEHDEKYGVPSLEEL 1
2 GFDTDGLPSAVWPGGETEALTRLERHLERK 0
0 AWVANFERPRMNANSLLASPTGLSPYLRFGCLSCRLFYFKLTDLYKK 0
0 VKKNSSPPLSLYGQLLWREFFYTAATNNPRFDKMEGNPICVQIPWDRNPEALAKWAEGRTGFPWIDAIMTQLRQEGWIHHLARHAVACFLTRGDLWISWEEGMK 0
0 VFEELLLDADWSINAGSWMWLSCSSFFQQFFHCYCPVGFGRRTDPNGDYIR 2
1 RYLPVLRGFPAKYIYDPWNAPEGIQKVAKCLIGVNYPKPMVNHAEASRLNIERMKQIYQQLSRYRGL 1
2 GLLASVPSNPNGNGSLMAYTPGENIPGCSSGG 1
2 GYSQGSGISHYSHEDSQQAYMLKQ 1
2 GRSSLGVGGGKRPRQEEETQSINPKVQRQSTN* 0

>CRY1_macEug Macropus eugenii (wallaby) assembly frameshift
0 MGVNAVHWFRKGLRLHDNPALKECIEGADTVRCVYILDPWFAGSSNVGINRWR 2
1 FLLQCLEDLDANLRKLNSRLFVIRGQPADVFPRLFK 0
0 EWNITKLSIEYDSEPLGRNAMQLLKNWASEAGVEVIVRISHTLYDLDK 2
1  1
2 gFDTDGLPSAVWPGGETEALTRLERHLERK 0
0 AWVANFERPRMNANSLLASPTGLSPYLRFGCLSCRLFYFKLTDLYKK 0
0 VKKNSSPPLSLYGQLLWREFFYTAATNNPRFDKMEGNPICVQIPWDRNPEALAKWAEGRTGFPWIDAIMTQLRQEGWIHHLARHAVACFLTRGDLWISWEEGMK 0
0 VFEELLLDADWSINAGSWMWLSCSSFFQQFFHCYCPVGFGRRTDPNGDYIR 2
1 RYLPVLRGFPAKYIYDPWNAPEGVQKVAKCLIGVNYPKPMVNHAEASRLNIERMKQIYQQLSRYRGL 1
2 GLLASVPSNPNGNGSLMGYTTGENIPTCSSSGG 1
2 GYSQGSGISHYSHEDSQQAYVLKQ 1
2 GRNSLGGGKRHRQEEETQSIGSKMQRQSVN* 0

>CRY1_sarHar Sarcophilus harrisii (tasmanian devil) nearly identical to oppossum
0 2
1 FLLQCLEDLDANLRKLNSRLFVIRGQPADVFPRLFK 0
0 EWNIAKLSIEYDSEPFGKERDAAIKKLASEAGVEVIVRISHTLYDLDK 0
0 1
2 GFDTDGLPSAVWPGGETEALTRLERHLERK 0
0 AWVANFERPRMNANSLLASPTGLSPYLRFGCLSCRLFYFKLTDLYKK 0
0 VKKNSSPPLSLYGQLLWREFFYTAATNNPRFDKMEGNPICVQIPWDRNPEALAKWAEGRTGFPWIDAIMTQLRQEGWIHHLARHAVACFLTRGDLWISWEEGMK 0
0 VFEELLLDADWSINAGSWMWLSCSSFFQQFFHCYCPVGFGRRTDPNGDYIR 2
1 RYLPVLRGFPAKYIYDPWNAPEGIQKVAKCLIGVNYPKPMVNHAEASRLNIERMKQIYQQLSRYRGL 1
2 GLLASVPSNPNGNGGLMGYTSGENGPACNSGG 1
2 GYSQGSGISHYSHEDSQQAYILKQ 1
2 GRSSLSGGKRPRQEEETQSVGPKVQRQSVN* 0


>CRY1_ornAna Ornithorhynchus anatinus (platypus) XM_001508563 = rubbish, genomic frameshift, continuing exon 12
0 MGVNAVHWFRKGLRLHDNPALRDCVRGADTVRCVYILDPWFAGSSNVGINRWR 2
1 FLLQCLEDLDANLRKLNSRLFVIRGQPADVFPRLFK 0
0 EWNIAKLSIEYDSEPFGKERDAAIKKLASEAGVEVIVRISHTLYELDK 2
1 IIELNGGQPPLTYKRFQTLISRMDPLAMPVETITAEVMGKCMTPLSDDHDEKYGVPSLEEL 1
2 GFDTDGLPSAVWPGGETEALTRLERHLERK 0
0 AWVANFERPRMNANSLLASPTGLSPYLRFGCLSCRLFYFKLTDLYKK 0
0 VKKNSSPPLSLYGQLLWREFFYTAATSNPRFDKMEGNPICVQIPWDRNPEALAKWAEGRTGFPWIDAIMTQLRQEGWIHHLARHAVACFLTRGDLWISWEEGMK 0
0 VFEELLLDADWSVNAGSWMWLSCSSFFQQFFHCYCPVGFGRRTDPNGDYIR 2
1 RYLPVLRGFPAKYIYDPWNAPEGIQKAAKCIIGVNYPKPMVNHAEASRLNIERMKQIYQQLSRYRGL 1
2 GLLASVPSNPNANGSGGLMAYSPGENIPGCSSGGG 1
2 GVQMGASESH LLQTCVLGESHLGPSGIQQQ 1
2 GYCQGSGVLYYANGESHLTQ 1
2 GRSSLTPGLSGGKRPCQEEESQSIGPKVQRQSTD* 0

>CRY1_tacAcu Tachyglossus aculeatus (echidna) SRR000649.130490 short read transcripts corrected for frameshifts, skipped penultimate exon
0  2
1  0
0  2
1    ETITAEVMGKCVTPLSDDHDEKYGVPSLEEL 1
2 GFDTDGLPSAVWPGGEAEALTRLERHLERK 0
0 AWVANFERPRMNANSLLASPTGLTPYLRFGCLSCRLFYFKLTDLYKK 0
0 VKKNSSPPLSLYGQLLWREFFYTAATSNPRFDKMEGNPICVQIPWDRNPEALAKWAEGRTGFPWIDAImtqlrqeGWIHHLARHAVACFLTRGDLWISWEEGMK 0
0 VFEELLLDADWSVNAGSWMWLSCSSFFQQFFHCYCPVGFGRRTDPNGDYIR 2
1 RYLPVLRGFPAKYIYDPWNAPEGIQKAAKCIIGVNYPKPMVNHAEASRLNIERMKQIYQQLSRYRGL 1
2 GLLASVPSNPNANGSGGLMAYSPGENIPGCSSGG 1
2 GAQIGASESHLLQTCVLGESHLGPSGIQQQ 1
2  1
2 GRSSLTPGLSGGKRHCQEEESQSIGPKVQRQSTD* 0


>CRY1_allMis Alligator mississippiensis (alligator) scaffold-103537
0 MGVNAVHWFRKGLRLHDNPALRECIQGADTVRCVYILDPWFAGSSNVGINRWR 2
1 FLLQCLEDLDANLRKLNSRLFVIRGQPADVFPRLFK 0
0 EWNITKLSIEYDSEPFGKERDAAIKKLASEAGVEVIVRISHTLYDLDK 2
1 IIELNGGQPPLTYKRFQTLISRMEPLEMPVETITAEVMEKCTTPVSDDHDEKYGVPSLEEL 1
2 GFDTDGLPSAVWPGGETEALTRLERHLERK 0
0 AWVANFERPRMNANSLLASPTGLSPYLRFGCLSCRLFYFKLTDLYKK 0
0 VKKNSSPPLSLYGQLLWREFFYTAATSNPRFDKMEGNPICVQIPWDKNPEALAKWAEGRTGFPWIDAIMTQLRQEGWIHHLARHAVACFLTRGDLWISWEEGMK 0
0 VFEELLLDADWSVNAGSWMWLSCSSFFQQFFHCYCPVGFGRRTDPNGDYIR 2
1 RYLPVLRGFPAKYIYDPWNAPEGVQKAAKCMIGINYPKPMVNHAEASRLNIERMKQIYQQLSRYRGL 1
2 GLLATVPSNPNGNGNGGLMGYSPGENVSGCSRA 1
2 GAQMGSSDGHTVSVQPCALGESHGGSNGIQQQ 1
2 GYFQASSILHFPHGDDQQSHLLQQ 1
2 GRTSLSSGISAGKRPNPEEETQSIGPKVQRQSTN* 0

>CRY1_galGal Gallus gallus (chicken) 11684328 17324421 15459395
0 MGVNAVHWFRKGLRLHDNPALRECIRGADTVRCVYILDPWFAGSSNVGINRWR 2
1 FLLQCLEDLDANLRKLNSRLFVIRGQPADVFPRLFK 0
0 EWSIAKLSIEYDSEPFGKERDAAIKKLASEAGVEVIVRISHTLYDLDK 2
1 IIELNGGQPPLTYKRFQTLISRMEPLEMPVETITPEVMQKCTTPVSDDHDEKYGVPSLEEL 1
2 GFDTDGLPSAVWPGGETEALTRLERH 0
0 LERKAWVANFERPRMNANSLLASPTGLSPYLRFGCLSCRLFYFKLTDLYKK 0
0 VKKNSSPPLSLYGQLLWREFFYTAATNNPRFDKMEGNPICVQIPWDKNPEALAKWAEGRTGFPWIDAIMTQLRQEGWIHHLARHAVACFLTRGDLWISWEEGMK 0
0 VFEELLLDADWSVNAGSWMWLSCSSFFQQFFHCYCPVGFGRRTDPNGDYIR 2
1 RYLPVLRGFPAKYIYDPWNAPESVQKAAKCVIGVNYPKPMVNHAEASRLNIERMKQIYQQLSRYRGL 1
2 GLLATVPSNPNGNGNGGLMSFSPGESISGCSSAG 1
2 GAQLGTGDGQTVGVQTCALADSHTGGSGVQQQ 1
2 GYCQASSILRYAHGDNQQSHLMQP 1
2 GRASLGTGISAGKRPNPEEETQSVGPKVQRQSTN* 0

>CRY1_melGal Meleagris gallopavo (turkey) XM_003202363
0  2
1 FLLQCLEDLDANLRKLNSRLFVIRGQPADVFPRLFK 0
0 EWSIAKLSIEYDSEPFGKERDAAIKKLASEAGVEVIVRISHTLYDLDK 2
1 IIELNGGQPPLTYKRFQTLISRMEPLEMPVETITPEVMQKCTTPVSDDHDEKYGVPSLEEL 1
2 GFDTDGLPSAVWPGGETEALTRLERH 0
0 LERKAWVANFERPRMNANSLLASPTGLSPYLRFGCLSCRLFYFKLTDLYKK 0
0 VKKNSSPPLSLYGQLLWREFFYTAATNNPRFDKMEGNPICVQIPWDKNPEALAKWAEGRTGFPWIDAIMTQLRQEGWIHHLARHAVACFLTRGDLWISWEEGMK 0
0 VFEELLLDADWSVNAGSWMWLSCSSFFQQFFHCYCPVGFGRRTDPNGDYIR 2
1 RYLPVLRGFPAKYIYDPWNAPESVQKAAKCVIGVNYPKPMVNHAEASRLNIERMKQIYQQLSRYRGL 1
2 GLLATVPSNPNGNGNGGLMSFSPGESISGCSSAG 1
2 GAQLGTGDGQTVGVQSCALGDSHTGGNGVQQQ 1
2 GYCQASSILRYAHGDNQQPHLMQP 1
2 GRASLGTGISAGKRPNPEEETQSVGPKVQRQSTN* 0

>CRY1_eriRub Erithacus rubecula (robin) AY585716
0 MGVNAVHWFRKGLRLHDNPALRECIRGADTVRCVYILDPWFAGSSNVGINRWR 2
1 FLLQCLEDLDANLRKLNSRLFVIRGQPADVFPRLFK 0
0 EWNIAKLSIEYDSEPFGKERDAAIKKLASEAGVEVIVRISHTLYDLDK 2
1 IIELNGGQPPLTYKRFQTLISRMEPLEMPVETITPEVMKKCTTPVFDDHDEKYGVPSLEEL 1
2 GFDTDGLPSAVWPGGETEALTRLERHLERK 0
0 ASVANFERPRMNANSLLASPTGLSPYLRFGCLSCRLFYFKLTDLYKK 0
0 VKKNSSPPLSLYGQLLWREFFYTAATNNPRFDKMEGNPICVQIPWDKNPEALAKWAEGRTGFPWIDAIMTQLRQEGWIHHLARHAVACFLTRGDLWISWEEGMK 0
0 VFEELLLDADWSVNAGSWMWLSCSSFFQQFFHCYCPVGFGRRTDPNGDYIR 2
1 RYLPVLRGFPAKYIYDPWNAPESIQKAAKCIIGVNYPKPMVNHAEASRLNIERMKQIYQQLSRYRGL 1
2 GLLATVPSNPNGNGNGGLMGYSPGESISGCGSTG 1
2 GAQLGTGDGHTVVQSCTLGDSHSGTSGIQQQ 1
2 GYCQASSILHYAHGDNQQSHLLQA 1
2 GRTALGTGISAGKRPNPEEETQSVGPKVQRQSTN* 0

>CRY1_sylBor Sylvia borin (warbler) AJ632120 15381765
0 MGVNAVHWFRKGLRLHDNPALRECIQGADTVRCVYILDPWFAGSSNVGINRWR 2
1 FLLQCLEDLDANLRKLNSRLFVIRGQPADVFPRLFK 0
0 EWNIAKLSIEYDSEPFGKERDAAIKKLASEAGVEVIVRISHTLYDLDK 2
1 IIELNGGQPPLTYKRFQTLISRMEPLEMPVETITPEVMKKCTTPVSDDHDEKYGVPSLEEL 1
2 GFDTDGLPSAVWPGGETEALTRLERHLERK 0
0 AWVANFERPRMNANSLLASPTGLSPYLRFGCLSCRLFYFKLTDLYKK 0
0 VKKNSSPPLSLYGQLLWREFFYTAATNNPRFDKMEGNPICVQIPWDKNPEALAKWAEGRTGFPWIDAIMTQLRQEGWIHHLARHAVACFLTRGDLWISWEE 0
0 VFEELLLDADWSVNAGSWMWLSCSSFFQQFFHCYCPVGFGRRTDPNGDYIR 2
1 RYLPVLRGFPAKYIYDPWNAPESIQKAAKCIIGVNYPKPMVNHAEASRLNIERMKQIYQQLSRYRGL 1
2 GLLATVPSNPNGNGNGGLMGYSPGESISGCGSTG 1
2 GAQLGAGDGHSVVQSCALGDSHTGTSGVQQQ 1
3 GYCQASSILHYAHGDNQQSHLLQA 1
2 GRTALGTGISAGKRPNPEEETQSVGPKVQRQSTN* 0

>CRY1_taeGut Taeniopygia guttata (finch) XM_002196518
0 2
1 FLLQCLEDLDANLRKLNSRLFVIRGQPADVFPRLFK 0
0 EWNIAKLSIEYDSEPFGKERDAAIKKLASEAGVEVIVRISHTLYDLDK 0
0 IIELNGGQPPLTYKRFQTLISRMEPLEMPVETITPEVMKKCTTPVSDDHDEKYGVPSLEEL 1
2 GFDTDGLPSAVWPGGETEALTRLERHLERK 0
0 AWVANFERPRMNANSLLASPTGLSPYLRFGCLSCRLFYFKLTDLYKK 0
0 VKKNSSPPLSLYGQLLWREFFYTAATNNPRFDKMEGNPICVQIPWDKNPEALAKWAEGRTGFPWIDAIMTQLRQEGWIHHLARHAVACFLTRGDLWISWEEGMK 0
0 GMKVFEELLLDADWSVNAGSWMWLSCSSFFQQFFHCYCPVGFGRRTDPNGDYIR 2
1 RYLPVLRGFPAKYIYDPWNAPESIQKAAKCIIGVNYPKPMVNHAEASRLNIERMKQIYQQLSRYRGL 1
2 GLLATVPSNPNGNGNGGLMGYSPGESISGCGSTG 1
2 GAQLGTGDGHSVVQSCALGDSHTGTSGIQQQ 1
2 GYCQASSILHYAHGDNQQSHLLQA 1
2 GRTALGTGISAGKRPNPEEETQSVGPKVQRQSTN* 0

>CRY1_melUnd Melopsittacus undulatus (budgerigar) AGAI01062111
1 RYLPVLRGFPAKYIYDPWNAPESIQKAAKCIIGVNYPKPMVNHAEASRLNIERMKQIYQQLSRYRGL
GLLATVPSNPNGNGNGGLMGYSPGESISGCSSAGG
GAQLGTGDGHTVVQPCALGDSHTAGASGIQQQ
GYCQASSILHYAHGDNQQSHLLQAG
VGTGISAGKRPNPEEETQSVGPKVQRQSTN* 0

>CRY1_anoCar Anolis carolinensis (lizard) XM_003220923
0 MGVNAVHWFRKGLRLHDNPALREVIQGADTVRCVYILDPWFAGSSNVGINRWR 2
1 FLLQCLEDLDANLRKLNSRLFVIRGQPADVFPRLFK 0
0 EWNITKLSIEYDSEPFGKERDAAIKKLASEAGVEVIVRISHTLYELDK 2
1 IIELNGGQPPLTYKRFQTLISRMEPLEIPVETITAEVMSKCTTPVSDDHDEKYGVPSLEEL 1
2 GFDTDGLPSAVWPGGETEALTRLERHLERK 0
0 AWVANFERPRMNANSLLASPTGLSPYLRFGCLSCRLFYFKLTDLYKK 0
0 VKKNSSPPLSLYGQLLWREFFYTAATNNPRFDKMEGNPICVQIPWDRNPEALAKWAEGRTGFPWIDAIMTQLRQEGWIHHLARHAVACFLTRGDLWISWEEGMK 0
0 VFEELLLDADWSVNAGSWMWLSCSSFFQQFFHCYCPVGFGRRTDPNGDYIR 2
1 RYLPVLRGFPAKYIYDPWNAPDGVQKAAKCIIGVNYPKPMVNHAEASRLNIERMKQMYQQLSRYRGL 1
2 GLLASVPSNGNGNGNGGLMGYSTGENIPGCTNTN 1
2 GSQMGMNEGHIGNVQACTMGESHTGTSGIQQQ 1
2 GYSQGSGILLYSHGDNQKTHSAQKGRISLGT 1
2 GVCTGKRPSPEVETQSVGPKVQRQSSN* 0

>CRY1_podSic Podarcis siculus (wall lizard) DQ376040 16809482
0 MGVNAVHWVRQGLRLPDNRALREVIQGADTARCVYILDPSFAGSSNVGINRWR 2
1 FLLQCLEDLDANLRKLNSRLFVIRGQPADVFPRLFK 0
0 EWNITKLSIEYDSEPFGKERDAAIKKLASEAGVEVIVRISHTLYDLDK 2
1 IIELNGGQPPLTYKRFQTLISRMEPLEMPVETITAEVMSKCTTPVSDDHDEKCGVPSLEEL 1
2 GFDTGGLPSAVWPGGETEALTRLERHLERK 0
0 AWVANFERPRMNANSLLASPTGLSPYLRFGCLSCRLFYFKLTDLYKK 0
0 VKKNSSPPLSLYGQLLWREFFYTAATNNPRFDKMEGNPICVQIPWDRNPEALAKWAEGRTGFPWIDAIMTQLRQEGWIHHLARRAVACFLTRGDLWISWEEGMK 0
0 VFEELLLDADWSVNAGSWMWLSCSSFFQQFFHCYCPVGFGRRTDPNGDYIR 2
1 RYLPVLRGFPAKYIYDPWNAPEGVQKVAKCVIGVNYPKPMVNHTEASRLNIERMKQIYQQLSRYRGL 1
2 GLLASVPLMEWNVIVLMGYHQGTLLVYHAS 1
2 GSQMGTNEAHTGSVQTCTLGESHTGTSGIQQQ 1
2 GYPQGSDILHYAHGEGQKTHLIQQGRASLVA 1
2 GVCTGKRPNPEEETQSIGPKVQRQSSK* 0

>CRY1_pytMol Python molurus (python) AEQU010547455 
0 MGVNSVHWFRKGLRLHDNPALREVIQGADTVRCVYILDPWFAGSSNVGINRWR 2
1 FLLQCLEDLDANLRKLNSRLFVIRGQPADVFPRLFk 0
0 EWNISKLSIEYDSEPFGKERDAAIKKLATEAGLEVIVRISHTLYDLDK 2
1 IIELNGGQPPLTYKRFQTLISRMEPLEMPVETITAEVMSKCTTPVSDDHDEKYGVPSLEEL 1
2 GFDTDGLPSAVWPGGETEALTRLERHLER 0
0 AWVANFERPRMNANSLLASPTGLSPYLRFGCLSCRLFYFKLTDLYKK 0
0 VKKNSSPPLSLYGQLLWREFFYTAATNNPRFDKMEGNPICVQIPWDKNPEALAKWAEGRTGFPWIDAIMTQLRQEGWIHHLARHAVACFLTRGDLWISWEEGMK 0 
2 VFEELLLDADWSVNAGSWMWLSCSSFFQQFFHCYCPVGFGRRTDPNGDYIR 2
1 RYLPILRGFPAKYIYDPWNAPEGVQKAAKCIIGINYPKPMVNHAEASRLNIERMKQIYQQLSRYRGL
2  1
2 GAQMGTSEGHTGNVQACTLGETHTGTSGIQQQ 1
2 GYSQGNSGILHYAHGDSQKTLLMQ 1
2 GRTSLSVGVCTGKRPNPEEGIQSIGPKVQRQSSN* 0

>CRY1_chrPic Chrysemys picta (turtle) AHGY01469963 AHGY01469969
0 MGVNAVHWFRKGLRLHDNPALRECIQGADSVRCVYILDPWFAGSSNVGINRWR 2
1 FLLQCLEDLDANLRKLNSRLFVIRGQPADVFPRLFK 0
0 EWNIAKLSIEYDSEPFGKERDAAIKKLASEAGVEVIVRISHTLYDLDK 2
1 IIELNGGQPPLTYKRFQTLISRMEPLEMPVETITAEVMEKCTTPVSDDHDEKYGVPSLEEL 1
2 GFDTDGLPSAVWPGGETEALTRLERHLERK 0
0 AWVANFERPRMNANSLLASPTGLSPYLRFGCLSCRLFYFKLTDLYKK 0
0 VKKNRSPPLSLYGQLLWREFFYTAATNNPRFDKMEGNPICVQIPWDRNPEALAKWAEGRTGFPWIDAIMTQLRQEGWIHHLARHAVACFLTRGDLWISWEEGMK 0
0 VFEELLLDADWSVNAGSWMWLSCSSFFQQFFHCYCPVSFGRRTDPNGDYIR 2
1 RYLPILRGFPAKYIYDPWNAPESIQKAAKCVIGVHYPKPMVNHAEASRLNIERMKQIYQQLSRYRGL 1
2 GLLATVPSNP  NGNGGLMGYSPGENISGCSSAS 1
2 GAQMGSNDGHTVGVQTCSLEDSHAGSSGIQQH 1
2 GYSQGNSIVHYAQGDHQQSHLLQQG 1
2 GRTVSTGISTGKRPNPEKETQSIGPKVQRQSTN* 0  


>CRY1_xenTro Xenopus tropicalis (frog) NM_001087660 11533577 final four exons confirmed by many ESTs
0 MGVNAVHWFRKGLRLHDNPALRECIQGADTVRCVYILDPWFAGSSNVGINRWR 2
1 FLLQCLEDLDANLRKLNSRLFVIRGQPADVFPRLFK 0
0 EWKITKLSIEYDSEPFGKERDAAIKKLASEAGVEVIVRISHTLYDLDK 2
1 IIELNGGQPPLTYKRFQTLISKMDPLEIPVETITAEVMEKCTTPVSDDHDEKYGVPSLEEL 1
2 GFDTEGLPSAVWPGGETEALTRLERHLERK 0
0 AWVANFERPRMNANSLLASTTGLSPYLRFGCLSCRLFYFKLTDLYKK  0
0 VKKNSSPPLSLYGQLLWREFFYTAATNNPRFDKMDGNPICVQIPWDRNPEALAKWAEGRTGFPWIDAIMTQLRQEGWIHHLARHAVACFLTRGDLWISWEEGMK 0
0 VFEELLLDADWSVNAGSWMWLSCSSFFQQFFHCYCPVGFGKRTDPNGDYIR 2
1 RYLPILKGFPPKYIYDPWNAPETVQKAAKCIIGVNYPKPMVNHAEASRLNIERMKQIYQQLSRYRGL 1
2 GLLASVPSNPNGNGNGGLMSYSPGESMSGCSNNG 1
2 GGQMGVNEGSSASNPNANKGEVHPGTSGLQ 1
2 GYWQGSSILHYSHSDSQQSYLMQ 1
2 ARNPLHSVVSSGKRPNPEEETQSIGPKVQRQSSH* 0

>CRY1_latCha Latimeria chalumnae (coelocanth) 
0 MGVNAIHWFRKGLRLHDNPALREAIQGGDCIRCVYILDPWFAGSSNVGINRWR 2
1 FLLQCLEDLDANLRKLNSRLFVIRGQPADVFPRLFK 0
0 EWNISRLSFEYDSEPFGKERDAAIKKLASEAGVEVIVRITHTLYDLDR 2
1 IIELNGGQPPLTYKRFQTLISRMEPLDLPVETINSEVMGNCSTPVSDDHDEKYGVPSLEEL 1
2 GFDTEGLPSAVWPGGETEALTRLERHLERK 0
0 AWVANFERPRMNANSLLASPTGLSPYLRFGCLSCRLFYFKLTDLYKK 0
0 VKKNSSPPLSLYGQLLWREFFYTAATNNPRFDKMEGNPICVQIPWDKNPEALAKWAEGKTGFPWIDAIMTQLRQEGWIHHLARHAVACFLTRGDLWISWEEGMK 0
0 VFEELLLDADWSVNAGSWMWLSCSSFFQQFFHCYCPVGFGRRTDPNGDYIR 2
1 RYLPVLRGFPAKYIYDPWNAPEGVQKAAKCIIGVNYPKPMVNHAEASRLNIERMKQIYQQLSRYRGM 1
2 GLLASVPSNPNGNGGLGCSLAENIPVCNSAA 1
2 GAQMGGDDGHKVSVLAYTQGDSRAGEIEMQQQ gcyi* 1
2  1
2  * 0

>CRY1_danRer Danio rerio (zebrafish) NM_001077297
0 MVVNTVHWFRKGLRLHDNPSLRDSILGAHSVRCVYILDPWFAGSSNVGISRWR 2
1 FLLQCLEDLDASLRKLNSRLFVIRGQPTDVFPRLFK
0 EWNINRLSYEYDSEPFGKERDAAIKKLANEAGVEVIVRISHTLYDLDK 2
0 IIELNGGQSPLTYKRFQTLISRMEAVETPAETITAEVMGPCTTPLSDDHDEKFGVPSLEEL 1
2 GFDTEGLSSAVWPGGETEALTRLERHLERK 0
0 AWVANFERPRMNANSLLASPTGLSPYLRFGCLSCRLFYFKLTDLYRK 0
0 VKKNSSPPLSLYGQLLWREFFYTAATNNPRFDKMEGNPICVQIPWDKNPEALAKWAEGRTGFPWIDAIMTQLRQEGWIHHLARHAVACFLTRGDLWISWEEGMK 0
0 VFEELLLDADWSVNAGSWMWLSCSSFFQQFFHCYCPVSFGRRTDPNGDYIR 2
1 RYLPVLRGFPAKYIYDPWNAPESVQKAAKCIIGVHYPMPMVHHAEASRLNIERMKQIYQQLSCYRGL 1
2 GLLAMVPSNPNGNGENSTSLMGFQTGDMTKEVTTPS 1
2 GYQMPPTSQGEWHGRTMVYSQGDQQTSSIMTSQ 1
2 GFGNNGSTMCYRQDAQQIT 1
2 GRGLHSSIIQTSGKRHSEESGPTTVSKVQRQCSS* 0

Vertebrate CRY2 reference sequences

These are pre-curated provisional sequences, taken from the UCSC 46-way genomic alignment relative to human. That results in omission of insertions in other species and missing exons in the situation where they are too diverged or lie in isolated small contigs. The final exons, being quite variable, are best determined from transcripts when available and then extended by blastx homology to species within the same clade lacking transcripts. After these corrections, the sequences are aligned and further anomalies are confirmed or discarded on a case-by-base basis.

>CRY2_homSap Homo sapiens (human) 11 exons
0 MAATVATAAAVAPAPAPGTDSASSVHWFRKGLRLHDNPALLAAVRGARCVRCVYILDPWFAASSSVGINRWR 2
1 FLLQSLEDLDTSLRKLNSRLFVVRGQPADVFPRLFK 0
0 EWGVTRLTFEYDSEPFGKERDAAIMKMAKEAGVEVVTENSHTLYDLDR 2
1 IIELNGQKPPLTYKRFQAIISRMELPKKPVGLVTSQQMESCRAEIQENHDETYGVPSLEEL 1
2 GFPTEGLGPAVWQGGETEALARLDKHLERK 0
0 AWVANYERPRMNANSLLASPTGLSPYLRFGCLSCRLFYYRLWDLYKK 0
0 VKRNSTPPLSLFGQLLWREFFYTAATNNPRFDRMEGNPICIQIPWDRNPEALAKWAEGKTGFPWIDAIMTQLRQEGWIHHLARHAVACFLTRGDLWVSWESGVR 0
0 VFDELLLDADFSVNAGSWMWLSCSAFFQQFFHCYCPVGFGRRTDPSGDYIR 2
1 RYLPKLKAFPSRYIYEPWNAPESIQKAAKCIIGVDYPRPIVNHAETSRLNIERMKQIYQQLSRYRGL 1
2 CLLASVPSCVEDLSHPVAEPSSSQAGSMSSA 1
2 GPRPLPSGPASPKRKLEAAEEPPGEELSKRARVAELPTPELPSKDA* 0

>CRY2_panTro Pan troglodytes (chimp)
0 MAATVATAAAVAPAPAPGTDGASSVHWFRKGLRLHDNPALLAAVRGARCVRCVYILDPWFAASSSVGINRWR 2
1 FLLQSLEDLDTSLRKLNSRLFVVRGQPADVFPRLFK 0
0 EWGVTRLTFEYDSEPFGKERDAAIMKMAKEAGVEVVTENSHTLYDLDR 2
1 IIELNGQKPPLTYKRFQAIISRMELPKKPVGSVTSQQMESCRAEIQENHDETYGVPSLEEL 1
2 GFPTEGLGPAVWQGGETEALARLDKHLERK 0
0 AWVANYERPRMNANSLLASPTGLSPYLRFGCLSCRLFYYRLWDLYKK 0
0 VKRNSTPPLSLFGQLLWREFFYTAATNNPRFDRMEGNPICIQIPWDRNPEALAKWAEGKTGFPWIDAIMTQLRQEGWIHHLARHAVACFLTRGDLWVSWESGVR 0
0 VFDELLLDADFSVNAGSWMWLSCSAFFQQFFHCYCPVGFGRRTDPSGDYIR 2
2 RYLPKLKAFPSRYIYEPWNAPESIQKAAKCIIGVDYPRPIVNHAETSRLNIERMKQIYQQLSRYRGL 1
2 CLLASVPSCVEDLSHPVAEPSSSQAGSMSSA 1
2 GPRPLPSGPASPKRKLEAAEEPPGEELSKRARVAELPTPELPSKDA* 0

>CRY2_gorGor Gorilla gorilla (gorilla)
0 MAATVATAAAVAPAPAPGTDGASSVHWFRKGLRLHDNPALLAAVRGARCVRCVYILDPWFAASSSVGINRWR 2
1 FLLQSLEDLDTSLRKLNSRLFVVRGQPADVFPRLFK 0
0 ------------------------------------------------ 2
1 IIELNGQKPPLTYKRFQAIISRMELPKKPVGSVTSQQMESCRAEIQENHDETYGVPSLEEL 1
2 GFPTEGLGPAVWQGGETEALARLDKHLERK 0
0 AWVANYERPRMNANSLLASPTGLSPYLRFGCLSCRLFYYRLWDLYKK 0
0 VKRNSTPPLSLFGQLLWREFFYTAATNNPRFDRMEGNPICIQIPWDRNPEALAKWAEGKTGFPWIDAIMTQLRQEGWIHHLARHAVACFLTRGDLWVSWESGVR 0
0 VFDELLLDADFSVNAGSWMWLSCSAFFQQFFHCYCPVGFGRRTDPSGDYIR 2
2 RYLPKLKAFPSRYIYEPWNAPESIQKAAKCIIGVDYPRPIVNHAETSRLNIERMKQIYQQLSRYRGL 1
2 CLLASVPSCVEDLSHPVAEPSSSQAGSVSSA 1
2 GPRPLPSGPASPKRKLEAAEEPPGEELSKRARVAELPTPELPSKDA* 0

>CRY2_ponAbe Pongo pygmaeus (orang_sumatran)
0 MAATVATAAAVAPAPAPGTDGASSVHWFRKGLRLHDNPALLAAVRGARCVRCVYILDPWFAASSSVGINRWR 2
1 FLLQSLEDLDTSLRKLNSRLFVVRGQPADVFPRLFK 0
0 EWGVTRLTFEYDSEPFGKERDAAIMKMAKEAGVEVVTENSHTLYDLDR 2
1 IIELNGQKPPLTYKRFQAIISRMELPKKPVGSVTSQQMESCRAEIQENHDETYGVPSLEEL 1
2 GFPTEGLGPAVWQGGETEALARLDKHLERK 0
0 AWVANYERPRMNANSLLASPTGLSPYLRFGCLSCRLFYYRLWDLYKK 0
0 VKRNSTPPLSLFGQLLWREFFYTAATNNPRFDRMEGNPICIQIPWDRNPEALAKWAEGKTGFPWIDAIMTQLRQEGWIHHLARHAVACFLTRGDLWVSWESGVR 0
0 VFDELLLDADFSVNAGSWMWLSCSAFFQQFFHCYCPVGFGRRTDPSGDYIR 2
2 RYLPKLKAFPSRYIYEPWNAPESIQKAAKCIIGVDYPRPIVNHAETSRLNIERMKQIYQQLSRYRGL 1
2 CLLASVPSCVEDLSHPVAEPSSSQAGSVSSA 1
2 GPRPLPSGPASPKRKLEAAEEPPGEELSKRARVAELPTPELPSKDA* 0

>CRY2_rheMac Macaca mulatta (rhesus) CJ488220 testis
0 MAATVATAAAVAPAPAPGTDGASSVHWFRKGLRLHDNPALLAAVRGARCVRCVYILDPWFAASSSVGINRWR 2
1 FLLQSLEDLDTSLRKLNSRLFVVRGQPADVFPRLFK 0
0 EWGVTRLTFEYDSEPFGKERDAAIMKMAKEAGVEVVTENSHTLYDLER 2
1 IIELNGQKPPLTYKRFQAIISRMELPKKPVGSVTSQQMESCRAEIQENHDETYGVPSLEEL 1
2 GFPTEGLGPAVWQGGETEALARLDKHLERK 0
0 AWVANYERPRMNANSLLASPTGLSPYLRFGCLSCRLFYYRLWDLYKK 0
0 VKRNSTPPLSLFGQLLWREFFYTAATNNPRFDRMEGNPICIQIPWDRNPEALAKWAEGKTGFPWIDAIMTQLRQEGWIHHLARHAVACFLTRGDLWVSWESGVR 0
0 VFDELLLDADFSVNAGSWMWLSCSAFFQQFFHCYCPVGFGRRTDPSGDYIR 2
2 RYLPKLKGFPSRYIYEPWNAPESIQKAAKCIIGVDYPRPIVNHAETSRLNIERMKQIYQQLSRYRGL 1
2 CLLASVPSCVEDLSHPVAEPSSSQAGSVNSA 1
2 GPRPLPSGPASPKRKLEAAEEPPGEELSKRAKVAELPTPELPSKDA* 0

>CRY2_papHam Papio hamadryas (baboon)
0 MAATVATAAAVAPAPAPGTDGASSVHWFRKGLRLHDNPALLAAVRGARCVRCVYILDPWFAASSSVGINRWR 2
1 FLLQSLEDLDTSLRKLNSRLFVVRGQPADVFPRLFK 0
0 EWGVTRLTFEYDSEPFGKERDAAIMKMAKEAGVEVVTENSHTLYDLER 2
1 IIELNGQKPPLTYKRFQAIISRMELPKKPVGSVTSQQMESCRAEIQENHDETYGVPSLEEL 1
2 GFPTEGLGPAVWQGGETEALARLDKHLERK 0
0 AWVANYERPRMNANSLLASPTGLSPYLRFGCLSCRLFYYRLWDLYKK 0
0 VKRNSTPPLSLFGQLLWREFFYTAATNNPRFDRMEGNPICIQIPWDRNPEALAKWAEGKTGFPWIDAIMTQLRQEGWIHHLARHAVACFLTRGDLWVSWESGVR 0
0 VFDELLLDADFSVNAGSWMWLSCSAFFQQFFHCYCPVGFGRRTDPSGDYIR 2
2 RYLPKLKGFPSRYIYEPWNAPESIQKAAKCIIGVDYPRPIVNHAETSRLNIERMKQIYQQLSRYRGL 1
2 CLLASVPSCVEDLSHPVAEPSSSQAGSVNSA 1
2 GPRPLPSGPASPKRKLEAAEEPPGEELSKRAKVAELPTPELPSKDA* 0

>CRY2_calJac Callithrix jacchus (marmoset)
0 MAATVATAAAAVPAPAPGTDGASSVHWFRKGLRLHDNPALLAAVRGARCVRCVYILDPWFAASSSVGINRWR 2
1 FLLQSLEDLDTSLRKLNSRLFVVRGQPADVFPRLFK 0
0 EWGVTRLTFEYDSEPFGKERDAAIMKMAKEAGVEVVTENSHTLYDLDR 2
1 IIELNGQKPPLTYKRFQAIISRMELPKKPVGSVTSQQMESCRAEIQENHDETYGVPSLEEL 1
2 GFPTEGLGPAVWQGGETEALARLDKHLERK 0
0 AWVANYERPRMNANSLLASPTGLSPYLRFGCLSCRLFYYRLWDLYKK 0
0 VKRNSTPPLSLFGQLLWREFFYTAATNNPRFDRMEGNPICIQIPWDRNPEALAKWAEGKTGFPWIDAIMTQLRQEGWIHHLARHAVACFLTRGDLWVSWESGVR 0
0 VFDELLLDADFSVNAGSWMWLSCSAFFQQFFHCYCPVGFGRRTDPSGDYIR 2
2 RYLPKLKGFPSRYIYEPWNAPESIQKAAKCIIGVDYPRPIVNHAETSRLNIERMKQIYQQLSRYRGL 1
2 CLLASVPSCVEDLSHPVAEPSSSQAGSMSSA 1
2 GPRPLPSGPASPKRKLEAAEEPPGEELSKRARVAELPTPELPSKDV* 0

>CRY2_tarSyr Tarsius syrichta (tarsier)
0 ------------------------------------------------------------------------ 2
1 FLLQSLEDLDTSLRKLNSRLFVVRGQPADVFPRLFK 0
0 EWGVTRLTFEYDSEPFGKERDAAIMKMAKEAGVEVVTENSHTLYDLD- 2
2 -----------------------------------------RSEIQEKHGETYGEPSLDEL 1
2 GFPTEGLGPAVWQGGETEALARLDKHLERK 0
0 ----------------------------------------------- 0
0 VKRNSTPPLSLFGQLLWREFFYAAATNNPRFDRMEGNPICIQIPWDRNPEALAKWAEGKTGFPWIDAIMTQLRQEGWIHHLARHAVACFLTRGDLWVSWESGVR 0
0 VFDELLLDADFSVNAGSWMWLSCSAFFQQFFHCYCPVGFGRRTDPSGDYVR 2
2 RYLPRLKGFPSRYIYEPWNAPESVQKAAKCIIGVDYPRPIVNHAETSRLNIERMKQIYQQLSRYRGL 1
2 CLLASVPSCVEDLSHPVAEPSSSQAGSMSST 1
2 GPRPLPSGPASPKRKLEAAEEPPGEELSKRARVAELPTPELPSRDV* 0

>CRY2_micMur Microcebus murinus (mouse_lemur)
0 MATAVA-TAAAAPTPASSTDGASSVHWFRKGLRLHDNPALLAAVRGARCVRCVYILDPWFAASSSVGINRW- 2
2 ------------------------------------ 0
0 EWGVTRLTFEYDSEPFGKERDAAIMKMAKEAGVEVVTENSHTLYDLDR 2
1 IIELNGQKPPLTYKRFQAIISRMELPKKPVGSVTSQQMESCRAEIQENHDETYGVPSLEEL 1
2 GFPTEGLGPAVWQGGETEALARLDKHLERK 0
0 AWVANYERPRMNANSLLASPTGLSPYLRFGCLSCRLFYYRLWDLYKK 0
0 VKRNSTPPLSLFGQLLWREFFYTAATNNPRFDRMEGNPICIQIPWDRNPEALAKWAEGKTGFPWIDAIMTQLRQEGWIHHLARHAVACFLTRGDLWVSWESGVR 0
0 VFDELLLDADFSVNSGSWMWLSCSAFFQQFFHCYCPVGFGRRTDPSGDYIR 2
2 RYLPKLKGFPSRYIYEPWNAPESIQKAAKCIIGVDYPRPIVNHAETSRLNIERMKQIYQQLSRYRGL 1
2 CLLASVPSCVEDLSHPVAEPSSSQAGSMSST 1
2 GPRPLPSGPASPKRKLEAAEEPPGEELSKRARVTELPTPELPSKDA* 0

>CRY2_otoGar Otolemur garnettii (bushbaby)
0 MAAAVA---TAAQGPATSADGASSVHWFRKGLRLHDNPALLAAVRGARCVRCVYILDPWFAASSSVGINRWR 2
1 FLLQSLEDLDTSLRKLNSRLFVVRGQPADVFPRLFK 0
0 EWGVTRLTFEYDSEPFGKERDAAIMKMAKEAGVEVVTEN--------- 2
1 IIELNGQKPPLTYKRFQAIISRMELPKKPVGSVTSQQMESCRAEIQENHDETYGVPSLEEL 1
1 ------------------------------ 0
0 AWVANYERPRMNANSLLASPTGLSPYLRFGCLSCRLFYYRLWDLYKK 0
0 VKRNSTPPLSLFGQLLWREFFYTAATNNPRFDRMEGNPICIQIPWDRNPEALAKWAEGKTGFPWIDAIMTQLRQEGWIHHLARHAVACFLTRGDLWVSWESGVR 0
0 VFDELLLDADFSVNSGSWMWLSCSAFFQQFFHCYCPVGFGRRTDPSGDYIR 2
2 RYLPKLKGFPSRYIYEPWNAPESIQKAAKCIIGVDYPRPIVNHAETSRLNIERMKQIYQQLSRYRGL 1
2 CLLASVPSCMEDLSHPVAEPCSSQAGSINNT 1
2 GPRPLLSGSASPKRKLEAAEEPPGEELSKRARVTELPTPELPSKDA* 0

>CRY2_musMus Mus musculus (mouse) CF898022
0 MAAAAV-VAATVPAQSMGADGASSVHWFRKGLRLHDNPALLAAVRGARCVRCVYILDPWFAASSSVGINRWR 2
1 FLLQSLEDLDTSLRKLNSRLFVVRGQPADVFPRLFK 0
0 EWGVTRLTFEYDSEPFGKERDAAIMKMAKEAGVEVVTENSHTLYDLDR 2
1 IIELNGQKPPLTYKRFQALISRMELPKKPAVAVSSQQMESCRAEIQENHDDTYGVPSLEEL 1
2 GFPTEGLGPAVWQGGETEALARLDKHLERK 0
0 AWVANYERPRMNANSLLASPTGLSPYLRFGCLSCRLFYYRLWDLYKK 0
0 VKRNSTPPLSLFGQLLWREFFYTAATNNPRFDRMEGNPICIQIPWDRNPEALAKWAEGKTGFPWIDAIMTQLRQEGWIHHLARHAVACFLTRGDLWVSWESGVR 0
0 VFDELLLDADFSVNAGSWMWLSCSAFFQQFFHCYCPVGFGRRTDPSGDYIR 2
2 RYLPKLKGFPSRYIYEPWNAPESVQKAAKCIIGVDYPRPIVNHAETSRLNIERMKQIYQQLSRYRGL 1
2 CLLASVPSCVEDLSHPVAEPGSSQAGSISNT 1
2 GPRALSSGPASPKRKLEAAEEPPGEELTKRARVTEMPTQEPASKDS* 0
   
>CRY2_ratNor Rattus norvegicus (rat) DN948283 prostate
0 MAAAAVVAATVPAQSMGADGASSVHWFRKGLRLHDNPALLAAVRGARCVRCVYILDPWFAASSSVGINRWR 2
1 FLLQSLEDLDTSLRKLNSRLFVVRGQPADVFPRLFK 0
0 EWGVTRLTFEYDSEPFGKERDAAIMKMAKEAGVEVVTENSHTLYDLDR 2
1 IIELNGQKPPLTYKRFQALISRMELPKKPVGAVSSQHMENCRAEIQENHDDTYGVPSLEEL 1
2 GFPTEGLGPAVWQGGETEALARLDKHLERK 0
0 AWVANYERPRMNANSLLASPTGLSPYLRFGCLSCRLFYYRLWDLYRK 1
0 VKRNSTPPLSLFGQLLWREFFYTAATNNPRFDRMEGNPICIQIPWDRNPEALAKWAEGKTGFPWIDAIMTQLRQEGWIHHLARHAVACFLTRGDLWVSWESGVR 0
0 VFDELLLDADFSVNAGSWMWLSCSAFFQQFFHCYCPVGFGRRTDPSGDYIR 2
2 RYLPKLKGFPSRYIYEPWNAPESVQKAAKCIIGVDYPRPIVNHAETSRLNIERMKQIYQQLSRYRGL 1
2 CLLASVPSCVEDLSHPVAEPGSSQAGSISNT 1
2 GPRPLSSGPASPKRKLEAAEEPPGEELSKRARVTEMPAQEPPSKDS* 0

>CRY2_criGri Cricetulus griseus (Chinese hamster) XR_135830
0 MAAAAVVAGAPRGARVPALTMGADGASSVHWFRKGLRLHDNPALLAAVRGARCVRCVYILDPWFAASSSVGINRWR 2
1 FLLQSLEDLDTSLRKLNSRLFVVRGQPADVFPRLFK 0
0 EWGVTRLTFEYDSEPFGKERDAAIMKMAKEAGVEVVTENSHTLYDLDR 2
1 IIELNGQKPPLTYKRFQAIISRMELPKKPVGAVTSQQMENCRAEIQENHDDTYGVPSLEEL 1
2 GFPTEGLGPAVWQGGETEALARLDKHLERK 0
0 AWVANYERPRMNANSLLASPTGLSPYLRFGCLSCRLFYYRLWDLYKK 1
0 VKRNSTPPLSLFGQLLWREFFYTAATNNPRFDRMEGNPICIQIPWDRNPEALAKWAEGKTGFPWIDAIMTQLRQEGWIHHLARHAVACFLTRGDLWVSWESGVR 0
0 VFDELLLDADFSVNAGSWMWLSCSAFFQQFFHCYCPVGFGRRTDPSGDYIR 2
2 RYLPKLKGFPSRYIYEPWNAPESVQKAAKCIIGVDYPRPIVNHAETSRLNIERMKQIYQQLSRYRGL 1
2 CLLASVPSCVEDLSHPVAEPSSSQAGSISNT 1
2 GSRPLSSGPASPKRKLEAAEEPPGEELSKRARVTEMPAQEPQTKDA* 0

>CRY2_spaJud palax judaei (blind mole rat) AJ606300
0 MAAASVVVATSAAPAMAVDGGSSVHWFRKGLRLHDNPSLLAAVRGARCVRCVYILDPWFAASSSVGINRWR 2
1 FLLQSLEDLDTSLRKLNSRLFVVRGQPADVFPRLFK 0
0 EWGVTRLTFEYDSEPFGKERDAAIMKMAKEAGVEVVTENSHTLYDLDR 2
1 IIDLNGQKPPLTYKRFQAIISRMELPKKPVVAVTSQQMESCRAEIQDNHDDTYGVPSLEEL 1
2 GFPTEGLGPAVWQGGETEALARLDKHLERK 0
0 AWVANYERPRMNANSLLASPTGLSPYLRFGCLSCRLFYYRLWDLYKK 1
0 VKRNSTPPLSLFGQLLWREFFYTAATNNPRFDRMEGNPICIQIPWDRNPEALAKWAEGKTGFPWIDAIMTQLRQEGWIHHLARHAVACFPTRGDLWVSWESGVR 0
0 VFDELLLDADFSVNAGSWMWLSCSAFFQQFFHCYCPVGFGRRTDPSGDYIR 2
2 RYLPKLKGFPSRYIYEPWNAPESIQKAARCIIGVDYPRPMVNHAETSRLNIERMKQIYQQLSRYRGL 1
2 CLLASVPSCVEDLSHPVAEPSSSQPGSITNT 1
2 GPRPLSTGPASPKRKLEAAEEPPGEELSKRARVTELPAPEPASKDA* 0

>CRY2_dipOrd Dipodomys ordii (kangaroo_rat)
0 MAAAMVTAAVAVPAPPSGADGASSVHWFRKGLRLHDNPALLAAVRGARCVRCVYILDPWFAASSSVGINRWR 2
1 FLLQSLEDLDTSLRKLNSRLFVVRGQPADVFPRLFK 0
0 EWGVTRLTFEYDSEPFGKERDAAIMKMAKEAGVEVVTENSHTLYDLDR 2
1 IIELNGQKPPLTYKRFQAIISRMELPKKPVGSVTSQQMESCRAEIQENHDDTYGVPSLEEL 1
2 GFPTEGLGPAVWQGGETEALARLDKHLERK 0
0 AWVANYERPRMNANSLLASPTGLSPYLRFGCLSCRLFYYRLWDLYKK 0
0 VKRNSTPPLSLFGQLLWREFFYTAATNNPRFDRMEGNPICIQIPWDRNPEALAKWAEGKTGFPWIDAIMTQL-QEGWIHHLARHAVTCFLTRGDLWVSW-----
0 --------------------------------------------------- 2
2 RYLPRLKGFPSRYIYEPWNAPESIQKAAKCIIGVDYPRPIVNHAETSRLNIERMKQIYQQLSRYRGL 1
2 CLLASVPSCVEDLSHPVAEPSSSQAGSISST 1
2 GPRPLSSGPASPKRKLEAAEEPPGEELSKRARVTEMPAQEPPSKDS* 0

>CRY2_cavPor Cavia porcellus (guinea_pig)
0 MAAAVGTGTAAAPTPVTGAEGACSVHWFRKGLRLHDNPALLAAVRGARCVRCVYILDPWFAASSSVGINRWR 2
1 FLLQSLEDLDTSLRKLNSRLFVVRGQPADVFPRLFK 0
0 EWGVTRLTFEYDSEPFGKERDAAIMKMAKEAGVEVVTENSHTLYDLDR 2
1 IIELNGQKPPLTYKRFQAIISRMELPKKPVGAVSSQQMESCRAEIQENHDDTYGVPSLEEL 1
2 GFPTEGLGPAVWQGGETEALARLDKHLERK 0
0 AWVANYERPRMNANSLLASPTGLSPYLRFGCLSCRLFYYRLWDLYKK 0
0 VKRNSTPPLSLFGQLLWREFFYTAATNNPRFDRMEGNPICIQIPWDRNPEALAKWAEGKTGFPWIDAIMTQLRQEGWIHHLARHAVACFLTRGDLWVSWESGVR 0
0 VFDELLLDADFSVNAGSWMWLSCSAFFQQFFHCYCPVGFGRRTDPSGDYIR 2
2 RYLPKLKGFPSRYIYEPWNAPESIQKAAKCIIGVDYPRPIVNHAETSRLNIERMKQIYQQLSRYRGL 1
2 CLLASVPSCVEDLSHPVAEPSLSQAGSSTST 1
2 GPRPLPGGPASPKRKLEAAEEPPGEELSKRARVAELPTPEPPSKDA* 0

>CRY2_hetGla Heterocephalus glaber (mole-rat) EHA99865
0 MAAAVGTGTGAAPTPATGAEGACSVHWFRKGLRLHDNPALLAAVRGARCVRCVYILDPWFAASSSVGINRW 2
1 RFLLQSLEDLDTSLRKLNSRLFVVRGQPADVFPRLFK 0
0 EWGVTRLTFEYDSEPFGKERDAAIMKMAKEAGVEVVTENSHTLYDLDR 2
1 IIELNGQKPPLTYKRFQAIISRMELPKKPVGAVSSQQMKSCRAEIQENHDDTYGVPSLEEL 1
2 GFPTEGLGPAVWQGGETEALARLDKHLERK 0
0 AWVANYERPRMNANSLLASPTGLSPYLRFGCLSCRLFYYRLWDLYKK 0
0 VKRNSTPPLSLFGQLLWREFFYTAATNNPRFDRMEGNPICIQIPWDRNPEALAKWAEGKTGFPWIDAIMTQLRQEGWIHHLARHAVACFLTRGDLWVSWESGVR 0
0 VFDELLLDADFSVNAGSWMWLSCSAFFQQFFHCYCPVGFGRRTDPSGDYIR 2
1 RYLPKLKGFPSRYIYEPWNAPESVQKAAKCIIGVDYPRPIVNHAETSRLNIERMKQIYQQLSRYRGL
2 CLLASVPSCVEDLSHPVAEPTLSQAGSSSSTG 1
2 PRSLPDGPASPKRKLEAAEEPPGEELSKRARVAELPAPEPTSKDA* 0

>CRY2_speTri Spermophilus tridecemlineatus (squirrel)
0 MSASVVTTSATLLTP-TSADV-SSVHWFRKGLRL-DNPALLAAVRGARCVRCVYILDPWFAASSSVGINRWR 2
1 FLLQSLEDLDTSLRKLNSRLFVVRGQPADVFPRLFK 0
0 EWGVTRLTFEYDSEPFGKERDAAIMKMAKEAGVEVVTENSHT------ 2
1 IIELNGQKPPLTYKRFQAIISRMELPKKPVGAVSSQQMESCKAEIQEDHDDTYGVPSLEEL 1
2 GFPTEGLGPAVWQGGETEALARLDKHLERK 0
0 AWVANYERPRMNANSLLASPTGLSPYLRFGCLSCRLFYYRLWDLYKK 0
0 VKKNSTPPLSLFGQLLWREFFYTAATNNPRFDRMEGNPICIQIPWDRNPEALAKWAEGKTGFPWIDAIMTQLRQEGWIHHLARHAVACFLTRGDLWVSWESGVR 0
0 VFDELLLDADFSVNAGSWMWLSCSAFFQQFFHCYCPVGFGRRTDPSGDYIR 2
2 RYLPKLKGFPSRYIYEPWNAPESIQKAAKCIIGVDYPRPIVNHAETSRLNIERMKQIYQQLSRYRGL 1
2 CLLASVPSCVEDLSHPVAEPGSSQAGSISST 1
2 GPRPLSSGQASPKRKLEAAEEPPGEELSKRARVAELPTPELPSKDA* 0

>CRY2_oryCun Oryctolagus cuniculus (rabbit)
0 MAAAAAAAAAAVPAPAASANGASSVHWFRKGLRLHDNPALLAAVRGARCVRCVYILDPWFAASSSVGINRWR 2
1 FLLQSLEDLDTSLRKLNSRLFVVRGQPTDVFPRLFK 0
0 EWGVTRLTFEYDSEPFGKERDAAIMKMAKEAGVEVVTENSHTLYDLDR 2
1 IIELNGQKPPLTYKRFQAIISRMELPKKPAGSVTSQQLEGCRAEIQDNHDETYGVPSLEEL 1
2 GFPTEGLSPAVWQGGETEALARLDKHLERK 0
0 AWVANYERPRMNANSLLASPTGLSPYLRFGCLSCRLFYYRLWDLYKK 0
0 VKRNSTPPLSLFGQLLWREFFYTAATNNPRFDRMEGNPICIQIPWDRNPEALAKWAEGKTGFPWIDAIMTQLRQEGWIHHLARHAVACFLTRGDLWVSWESGVR 0
0 VFDELLLDADFSVNAGSWMWLSCSAFFQQFFHCYCPVGFGRRTDPSGDYVR 2
2 RYLPKLKGFPSRYIYEPWNAPESVQKAAKCIIGVDYPRPIVNHAETSRLNIERMKQIYQQLSRYRGL 1
2 CLLASVPSCVEDLSHPVAEPSSSQAGSVSGA 1
2 APRPLPSGPASPKRKLEAAEEPPGEELSKRARVAEVPTPELPSKAV* 0

>CRY2_ochPri Ochotona princeps (pika)
0 MMAATAA--AAVPAAAA---GASSVHWFRKGLRLHDNPALLAAVRGARCVRCVYILDPWFAASSSVGINRW- 2
2 ------------------------------------ 0
0 EWGVTRLTFEYDSEPFGKERDAAIMKMAREAGVEVVTENSHTLYDLDR 2
1 IIELNGQKPPLTYKRFQAIISRMELPRKPVGSVTSEQMESCRAEIQDNHDESYGVPSLEEL 1
1 ------------------------------ 0
0 ----------MNANSLLASPTGLSPYLRFGCLSCRLFYYRLWDLYKK 0
0 VKKNSSPPLSLYGQLLWREFFYTAATNNPRFDKMEGNPICVQIPWDKNPEALAKWAEGRTGFPWIDAIMTQLRQEGWIHHLARHAVACFLTRGDLWISWEEGMK
0 ---------DFSVNAGSWMWLSCSAFFQQFFHCYCPVGFGRRTDPSGDYIR 2
2 RYLPKLKGFPSRYIYEPWNAPESVQKAAKCIIGIDYPRPIVNHAETSRLNIERMKQIYQQLSRYRGL 1
2 CLLASVPSCVEDLSHPVAEPSSSQAGNVSST 1
2 GPRPLSSGPASPKRKLEAAEEPPGEELSKRARVAVVPAPELPSKAV* 0

>CRY2_vicPac Vicugna paca (vicugna)
0 MATAVATAAAAAPAPAAGAEGATSVHWFRKGLRLHDNPALLAAVRGAHCVRCVYILDPWFAASSSVGINRWR 2
1 FLLQSLEDLDTSLRKLNSRLFVVRGQPADVFPRLFK 0
0 EWGVTRLTFEYDSEPFGKERDAAIMKMAKEAGVEVVTENSHTLYDLDR 2
1 IIELNGQKPPLTYKRFQAIISRMELPKKPVGSVTSQQMESCRAEIQENHDETFGVPSLEEL 1
1 ------------------------------ 0
0 ----------------------------------------------- 0
0 VKRNSTPPLSLFGQLLWREFFYTAATNNPRFDRMEGNPICIQIPWDRNPEALAKWAEGKTGFPWIDAIMTQLRQEGWIHHLARHAVACFLTRGDLWVSWESGVR 0
0 VFDELLLDADFSVNAGSWMWLSCSAFFQQFFHCYCPVGFGRRTDPSGDYIR 2
2 RYLPKLKGFPSRYIYEPWNAPESVQKAAKCIIGVDYPRPMVNHAETSRLNIERMKQIYQQLSRYRGL 1
2 CLLASVPSCVEDLSNPVAEPSSSQAGSMSSA 1
2 GPRPLPGGPASPKRKLEAAEEPPGEELSKRARVAELPSTELPGRDV* 0

>CRY2_turTru Tursiops truncatus (dolphin)
0 MAAAVATSAVAAPAPAARAEGASSVHWFRKGLRLHDNPALQAAVRGAHCVRCVYILDPWFAASSSVGINRWR 2
1 FLLQSLEDLDTSLRKLNSRLFVVRGQPADVFPRLFK 0
0 EWGVTRLTFEYDSEPFGKERDAAIMKMAKEAGVEVVTENSHTLYDLDK 2
1 IIELNGQKPPLTYKRFQAIISRMELPKKPVGSVTSQQMEGCRAEIQENHDETYGVPSLEEL 1
2 GFPTEGLGPAVWQGGETEALARLDKHLERK 0
0 AWVANYERPRMNANSLLASPTGLSPYLRFGCLSCRLFYYRLWDLYKK 0
0 VKRSSTPPLSLFGQLLWREFFYTAATNNPRFDRMEGNPICIQIPWDRNPEALAKWAEGKTGFPWIDAIMTQLRQEGWIHHLARHAVACFLTRGDLWVSWESGVR 0
0 VFDELLLDADFSVNAGSWMWLSCSAFFQQFFHCYCPVGFGRRTDPSGDYIR 2
2 RYLPKLKGFPSRYIYEPWNAPESIQKAAKCIIGVDYPRPIVNHAETSRLNIERMKQIYQQLSRYRGL 1
2 CLLASVPSCMEDLSNPVAEPSSSQAGGMSSA 1
2 GPRPLPSGPASPKRKLGAAEEPPGEELSKRARVAGLPPSELLSKDV* 0

>CRY2_bosTau Bos taurus (cow) EG706191 lens
0 MAAA----AAATQAPAARGDGASSVHWFRKGLRLHDNPALLAAVRGAHCVRCVYILDPWFAASSSVGINRWr 2
2 ------------------------------------ 0
0 EWGVTRLTFEYDSEPFGKERDTAIMKMAKEAGVEVVTENSHTLYDLDK 2
1 IIELNGQKPPLTYKRFQAIISRMELPRKPVGSVTSQQMEGCRAEIQESHDETYGVPSLEEL 1
2 GFPTEGLGPAVWQGGETEALARLDKHLERK 0
0 AWVANYERPRMNANSLLASPTGLSPYLRFGCLSCRLFYYRLWDLYKK 0
0 VKRNSTPPLSLFGQLLWREFFYTAATNNPRFDRMEGNPICIQIPWDRNPEALAKWAEGKTGFPWIDAIMTQLRQEGWIHHLARHAVACFLTRGDLWVSWESGVR 0
0 VFDELLLDADFSVNAGSWMWLSCSAFFQQFFHCYCPVGFGRRTDPSGDYIR 2
2 RYLPKLKGFPSRYIYEPWNAPESIQKAAKCVIGVDYPRPIVNHAEASRLNIERMKQVYQQLSRYRGL 1
2 CLLASVPSCVEDLSNPVAEPSSIQAGSSSSV 1
2 GPRPLPGGPASPKRKLEAAEEPPGGELSKRARVAESLPSELPSRGV* 0

>CRY2_susScr Sus scrofa (pig) XM_003122835
0 MAAAVATAAASSPAPAAGAEGASSVHWFRKGLRLHDNPALLAAVRGAHCVRCVYILDPWFAASSSVGINRWR 2
1 FLLQSLEDLDTSLRKLNSRLFVVRGQPADVFPALFQ 0
0 EWGVTRLTFEYDSEPFGKERDAAIMKMAKEAGVEVVTENSHTLYDLDK 2
1 IIELNGQKPPLTYKRFQALISRMELPKKPVGSVTSQQMESCRAEIQENHDETYGVPSLEEL 1
2 GFPTEGLGPAVWQGGETEALARLDKHLERK 0
0 AWVANYERPRMNANSLLASPTGLSPYLRFGCLSCRLFYYRLWDLYKK 0
0 VKRNSTPPLSLFGQLLWREFFYTAATNNPRFDRMEGNPICIQIPWDRNPEALAKWAEGKTGFPWIDAIMTQLRQEGWIHHLARHAVACFLTRGDLWVSWESGVR 0
0 VFDELLLDADFSVNAGSWMWLSCSAFFQQFFHCYCPVGFGRRTDPSGDYIR 2
2 RYLPKLKGFPSRYIYEPWNAPESVQKAAKCIIGVDYPRPIVNHAETSRLNIERMKQIYQQLSRYRGL 1
2 CLLASVPSCVEDLSNPVAEPSSSQAGSVSAA 1
2 GPRPLPSGPASPKRKLEAAEEPPGEELSKRARVAELPPTELPGRDV* 0

>CRY2_equCab Equus caballus (horse)
0 ---------------------------------------------GGRGGCFLSLPGPGS-PPFWVGKKRGK 2
1 FLLQSLEDLDTSLRKLNSRLFVVRGQPADVFPRLFK 0
0 EWGVTRLTFEYDSEPFGKERDAAIMKMAKEAGVEVVTENSHTLYDLDR 2
1 IIELNGQKPPLTYKRFQAIISRMELPRKPVGSVTSQQMESCRADIQENHDETYGVPSLEEL 1
2 GFPTEGLGPAVWQGGETEALARLDKHLERK 0
0 AWVANYERPRMNAASLLASPTGLSPYLRFGCLSCRLFYYRLWDLYRK 0
0 VKRNSTPPLSLFGQLLWREFFYTAATNNPRFDRMEGNPICIQIPWDRNPEALAKWAEAKTGFPWIDAIMTQLRQEGWIHHLARHAVACFLTRGDLWVSWESGVR 0
0 VFDELLLDADFSVNAGSWMWLSCSAFFQQFFHCYCPVGFGRRTDPSGDYIR 2
2 RYLPKLKAFPSRYIYEPWNAPEAVQKAAKCIIGVDYPRPIVNHAETSRLNIERMKQIYQQLSRYRGL 1
2 CLLASVPSCVEDLSNPVAEPSSSQAGSVSSA 1
2 GPRPPPSGPASPKRKLEAAEEPPGEELSKRARV------EPPSRAV * 0

>CRY2_felCat Felis catus (cat)
0 ----------AAPAPAAGADGASSVHWFRKGLRLHDNPALLAAVRGARCVRCVYILDPWFAASSSVGINRWR 2
1 FLLQSLEDLDTSLRKLNSRLFVVRGQPADVFPRLFK 0
0 EWGVTRLTFEYDSEPFGKERDAAIMKMAKEAGVEVVTENSHTLYDLDR 2
1 IIDLNGQKPPLTYKRFQAIISRMELPKKPVGSVTSQQMESCRAEIQENHDEAYGVPSLEEL 1
2 GFPTEGLGPAVWQGGETEALARLDKHLERK 0
0 ----------------------------------------------- 0
0 VKRNSTPPLSLFGQLLWREFFYTAATNNPRFDRMEGNPICIQIPWDRNPEALAKWAEGKTGFPWIDAIMTQLRQEGWIHHLARHAVACFLTRGDLWVSWESGVR 0
0 VFDELLLDADFSVNAGSWMWLSCSAFFQQFFHCYCPVGFGRRTDPSGDYIR 2
2 RYLPMLKGFPSRYIYEPWNAPESIQKAAKCIIGVDYPRPIVNHAETSRLNIERMKQIYQQLSRYRGL 1
2 CLLASVPSCVEDLSNPVAEPSSSQTGNVSSA 1
2 ----------------------------------------------- * 0

>CRY2_canFam Canis familiaris (dog)
0 MAAAVVAAAAAAPVPTAGVDGASSVHWFRKGLRLHDNPALLAAVRGARCVRCVYILDPWFAASSSVGINRWR 2
1 FLLQSLEDLDTSLRKLNSRLFVVRGQPADVFPRLFK 0
0 EWGVTRLTFEYDSEPFGKERDAAIMKMAKEAGVEVVTENSHTLYDLDK 2
1 IIELNGQKPPLTYKRFQAIISRMELPKKPVGSVTSQQMESCRADIQDNHDDTYGVPSLEEL 1
2 GFPTEGLGPAVWQGGETEALARLDKHLERK 0
0 AWVANYERPRMNANSLLASPTGLSPYLRFGCLSCRLFYYRLWDLYKK 0
0 VKRNSTPPLSLFGQLLWREFFYTAATNNPRFDRMEGNPICIQIPWDRNPEALAKWAEGKTGFPWIDAIMTQLRQEGWIHHLARHAVACFLTRGDLWVSWESGVR 0
0 VFDELLLDADFSVNAGSWMWLSCSAFFQQFFHCYCPVGFGRRTDPSGDYIR 2
2 RYLPILKGFPSRYIYEPWNAPESIQKAAKCIIGVDYPRPIVNHAETSRLNIERMKQIYQQLSRYRGL 1
2 CLLASVPSCVEDLSNPVAEPSSSQTGSMSSA 1
2 GPRPLPSGPASPKRKLEAAEEPPGEELSKRARVAELPTPELPCRDV* 0

>CRY2_ailMel Ailuropoda melanoleuca (giant panda) XM_002922310
0            PAPAAGVDGASSVHWFRKGLRLHDNPALLAAVRGARCVRCVYILDPWFAASSSVGINRWR 2
1 FLLQSLEDLDTSLRKLNSRLFVVRGQPTDVFPRLFK 0
0 EWGVTRLTFEYDSEPFGKERDAAIMKMAKEAGVEVVTENSHTLYDLDK 2
1 IIELNGQKPPLTYKRFQAIISRMELPKKPVGSVTSQQMESCRADIQESHDDTYGVPSLEEL 1
2 GFPTEGLGPAVWQGGETEALARLDKHLERK 0
0 AWVANYERPRMNANSLLASPTGLSPYLRFGCLSCRLFYYRLWDLYKK 0
0 VKRNSTPPLSLFGQLLWREFFYTAATNNPRFDRMEGNPICIQIPWDRNPEALAKWAEGKTGFPWIDAIMTQLRQEGWIHHLARHAVACFLTRGDLWVSWESGVR 0
0 VFDELLLDADFSVNAGSWMWLSCSAFFQQFFHCYCPVGFGRRTDPSGDYIR 2
2 RYLPILKGFPSRYIYEPWNAPESIQKAAKCIIGVDYPRPIVNHAETSRLNIERMKQIYQQLSRYRGL 1
2 CLLASVPSCVEDLSNPVAEPSSSQTGSMSSA 1
2 GPRPLPSGPASPKRKLEAAEEPPGEELSKRARVAELPAPEPPSRDV* 0

>CRY2_myoLuc Myotis lucifugus (microbat)
0 MAANAVTAAAAAPAPAAGTDGASSVYWFRKGLRLHDNPALLAAVRGARCVLCVYILDPWFAASSSVGINRWR 2
1 FLLQSLEDLDTSLRKLNSRLFVVRGQPADVFPRLFK 0
0 EWGVTRLTFEYDSEPFGKERDAAIMKMAKEAGVEVVTENSHTLYDLDR 2
1 IIELNGQKPPLTYKRFQAIISRMELPKKPVASVTRHQMESCPAEIQENHDETYGVPSLEEL 1
2 GFPTEGLGPAVWQGGETEALARLDKHLERK 0
0 AWVANYERPRMNANSLLASPTGLSPYLRFGCLSCRLFYYRLWDLYKK 0
0 VKRNSSPPLSLFGQLLWREFFYTAATNNPRFDRMEGNPICIQIPWDRNPEALAKWAEGKTGFPWIDAIMTQLRQEGWIHHLARHAVACFLTRGDLWVSWESGFR
0 VFDELLLDADFSVNAGSWMWLSCSAFFQQFFHCYCPVGFGRRTDPSGDYIR 2
2 RYLPKLKGFPSRYIYEPWNAPESIQKAAKCIIGVDYPRPIVNHAETSRLNIERMKQIYQQLSRYRGL 1
2 CLLASVPSCMEDLSNPVAEPSLSQTGSMSSA 1
2 GPKPLPSGPASPKRKLEAAEEPPGEELSKRARVAELPATELPSRDV* 0

>CRY2_pteVam Pteropus vampyrus (macrobat)
0 MAATVGTAAAAASAPAAGTDGASSVHWFRKGLRLHDNPALLAAVRGARCVRCVYILDPWFAASSSVGINRWR 2
1 FLLQSLEDLDTSLRKLNSRLFVVRGQPTDVFPRLFK 0
0 EWGVTRLTFEYDSEPFGKERDAAIMKMAKEAGVEVVTENSHTLYDLDR 2
1 IIELNGQKPPLTYKRFQAIISRMELPKKPVGSVTSQHMESCTAEIQENHDETYGVPSLEEL 1
2 GFPTEGLGPAVWQGGETEALARLDKHLERK 0
0 AWVANYERPRMNANSLLASPTGLSPYLRFGCLSCRLFYYRLWDLYKK 0
0 VKRNSTPPLSLFGQLLWREFFYTAATNNPRFDRMEGNPICIQIPWDRNPEALAKWAEGKTGFPWIDAIMTQLRQEGWIHHLARHAVACFLTRGDLWVSWESGVR 0
0 VFDELLLDADFSVNAGSWMWLSCSAFFQQFFHCYCPVGFGRRTDPSGDYIR 2
2 RYLPKLKGFPSRYIYEPWNAPESIQKAAKCIIGVDYPRPIVNHAETSRLNIERMKQIYQQLSRYRGL 1
2 CLLASVPSCVEDLNNPVAEPSSSQTGSMNNA 1
2 GPRPLPSGPASPKRKLEAAEEPPGEELSKRARVAELPAPELPSRDV* 0

>CRY2_eriEur Erinaceus europaeus (hedgehog)
0 MAAVAVTAAAAAAGPGPVADGASSVHWFRKGLRLHDNPALLAAVRGARSVRCVYILDPWFAASSSVGINRW- 2
2 ------------------------------------ 0
0 EWGVTRLTFEYDSEPFGKERDTAIMKMAKEAGVEVVTENSHTLYDLDR 2
1 IIELNGQKPPLTYKRFQAIISRMELPRKPVGSVTSQQMESCRAEIQENHDETYGVPSLEEL 1
2 GFPTEGLGPAVWQGGETEALARLDKHLERK 0
0 AWVANYERPRMNANSLLASPTGLSPYLRFGCLSCRLFYYRLWDLYKK 0
0 VKRNSTPPLSLFGQLLWREFFYTAATNNPRFDRMEGNPICIQIPWDRNPEALAKWAEGKTGFPWIDAIMTQLRQEGWIHHLARHAVACFLTRGDLWVSWESGVR 0
0 VFDELLLDADFSVNAGSWMWLSCSAFFQQFFHCYCPVGFGRRTDPSGDYIR 2
2 RYLPKLKGFPSRYIYEPWNAPESVQKAAKCIIGVDYPRPIVNHAETSRLNIERMKQIYQQLSRYRGL 1
2 CLLASVPSCVEDLSNPMAEPSSSQAGSASSA 1
2 GPRSLTSGPASPKRKPKTAEEPP------------------------ * 0

>CRY2_sorAra Sorex araneus (shrew)
0 MATAAAAAAAAAPAPAARAEGACSVHWFRKGLRLHDNPALLAAVRGARCVRCVYILDPWFAASSSVGINRWR 2
1 FLLQSLEDLDTSLRKLNSRLFVVRGQPADVFPRLFK 0
0 ------------------------------------------------ 2
1 IIELNGQKPPLTYKRFQAIIGRMELPMKPVGSVSRQQMESCRAEIQENHDETYGVPSLEGL 1
2 GFPTEGLGPAVWQGGETEALARLDKHLERK 0
0 ----------------------------------------------- 0
0 VKRSHTPPLSLFGKLPWRE-LYTSATNHPRSDRM-ENPICIPDPWDRNPEALAKWAEGKTGFPWIDAIMTQLRQEGWIHHLARHAVACFLTRGDLWVSWESGVR 0
0 VFDELLLDADFSVNAGSWMWLSCSAFFQQFFHCYCPVGFGRRTDPSGDYIR 2
2 RYLPKLKGFPSRYIYEPWNAPEAVQKAAKCVIGVDYPRPMVNHAETNRLTIERMKQIYQKLSSYWGH 1
2 CLLASVPSCVEELSNPMAEPSGSQAG--SSA 1
2 ----------------------------------------------- * 0

>CRY2_loxAfr Loxodonta africana (elephant)
0 MAAAVVTAGAAALVPIPSMDGASSVHWFRKGLRLHDNPALLAAVRGARCVRCVYILDPWFAASSSVGINRWR 2
1 FLLQSLEDLDTSLRKLNSRLFVVRGQPADVFPRLFK 0
0 EWGVTRLTFEYDSEPFGKERDAAIMKMAKEAGVEVVTENSHTLYDLDR 2
1 IIELNGQKPPLTYKRFQAIISRMELPKKPVGSVTSQQMESCRAEIQENHDETYGVPSLEEL 1
2 GFPTEGLGPAVWQGGETEALARLDKHLERK 0
0 AWVANYERPRMNANSLLASPTGLSPYLRFGCLSCRLFYYRLWELYKK 0
0 VKRNSTPPLSLFGQLLWREFFYTAATNNPRFDRMEGNPICIQIPWDRNPEALAKWAEGKTGFPWIDAIMTQLRQEGWIHHLARHAVACFLTRGDLWVSWESGVR 0
0 VFDELLLDADFSVNAGSWMWLSCSAFFQQFFHCYCPVGFGRRTDPSGDYIR 2
2 RYLPKLKGFPSRYIYEPWNAPESIQKAAKCIIGVDYPRPIVNHAETSRLNIERMKQIYQQLSRYRGL 1
2 CLLASVPSCVEDLSSPVAEPSSSQAGSSNSA 1
2 GPRPLPSGPTSPKRKLEAAEEPPGEELSKRARVAKLPGPELPSKDV * 0

>CRY2_proCap Procavia capensis (hyrax)
0 MAATAATAVAAALAPAPTADGVSSVHWFRKGLRLHDNPALLAAVRGARCVRCVYILDPWFAASSSVGINRWR 2
1 FLLQSLEDLDTSLRKLNSRLFVVRGQPADVFPRLFK 0
0 -----------------------------EAG-RVVTENSHTLYDLDR 2
1 IIELNGQKPPLTYKRFQAIVSRMELPRKPVGSVTSQQMESCRAEMQENHEEIYGVPSLEEL 1
2 GFPTEGLGPAVWQGGETEALARLDKHLERK 0
0 ----------------------------------------------- 0
0 VKRNSTPPLSLFGQLLWREFFYTAATNNPRFDRMEGNPICIQIPWDRNPEALAKWAEGKTGFPWIDAIMTQLRQEGWIHHLARHAVACFLTRGDLWVSWESGVR 0
0 VFDELLLDADFSVNAGSWMWLSCSAFFQQFFHCYCPVGFGRRTDPSGDYIR 2
2 RYLPKLKGFPSRYIYEPWNAPESIQKAAKCIIGVDYPRPIVNHAETSRLNIERMKQIYQQLSRYRGL 1
2 CLLASVPSCVEDLSNPVAEPSSSPAGHMSSA 1
2 GLRPLPSGPASPKRKLEAAEEPPGEELSKRARVAKLPGPELPSTDA* 0

>CRY2_echTel Echinops telfairi (tenrec)
0 MAAAVGTAALAATAPAPNKDGASSVHWFRKGLRLHDNPALLAAVRGARCVRCVYILDPWFAASSSVGINRWR 2
1 FLLQSLADLDARLRTLHSRLFVVRGQPADVFPRLFK 0
0 EWGVTRLTFEYDSEPFGKERDAAIMKLAKEAGVEVVTENSHTLYDLDR 2
1 IIELNGQKPPLTYKRFQAIISRMELPRKPAGAPTGLQMESCQAEIPENHAETYGVPSLEEL 1
2 GFPTEGLGPAVWQGGETEALARLDKHLERK 0
0 AWVASYERPRMNANSLLASPTGLSPYLRFGCLSCRLFYYRLWDLYKK 0
0 VKRNSTPPLSLFGQLLWREFFYTAATTNPRFDRMEGNPICIQIPWDRNPEALAKWAEGKTGFPWIDAIMTQLRQEGWIHHLARHAVACFLTRGDLWVSWESGVR 0
0 VFDELLLDADFSVNAGSWMWLSCSAFFQQFFHCYCPVGFGRRTDPSGDYI- 2
2 ------------------------------------------------------------------- 1
1 ------------------------------- 1
2 -----------------------------------------------* 0

>CRY2_choHof Choloepus hoffmanni (sloth)
0 MAATAVMAGSAAPAPASGTEGASSVHWFRKGL*LHDNPALLAAVRGARCVRCVYILDPWFAASSSVGINRWR 2
1 FLLQSLEDLDTSLRKLNSRLFVVRGQPADVFPRLFK 0
0 EWGVTRLTFEYDSEPFGKERDAAIMKMAKEAGVEVVTENSHTLYDLDR 2
1 IIELNGQKPPLTYKRFQAIISRMELPKKPVGSVTSQQMESCRAEIQENHDETYGVP----- 1
1 -FPTEGLGPAVWQGGEAEALARLDKHLERK 0
0 AWVANFERPQMNANSLLASPTGLSPYLQFGCLSCQLFYFKLTDLYKK 0
0 VKRNSTPPLSLFGQLLWREFFYTAATNNPRFDRMEGNPICIQIPWDRNPEALAKWAEGKTGFPWIDAIMTQLRQEGWIHHLARHAVACFLTRGDLWVSWESGVR 0
0 VFDELLLDADFSVNSGSWMWLSCSAFFQQFFHCYCPVGFGRRTDPSGDYIR 2
2 RYLPKLKGFPSRYIYEPWNAPESIQKAAKCIIGVDYPRPIVNHAETSRLNIERMKQIYQQLSRYRGL 1
2 CLLASVPSCVEDLSNPVAEPSSSQAGSMSSA 1
2 GPRPVPSGPASPKRKLEAAEEPPGEELSKRARVTELPTPELPSKDV* 0

>CRY2_macEug Macropus eugenii (wallaby) FY652314 testis
0 ------------------------------------------------------------------------ 2
1 FLLQSLEDLDISLRKLNSRLFVVRGQPTDVFPRLFK 0
0 EWGVTRLTFEYDSEPFGKERDAAIVKMAKEAGVEVVTENSHTLYDLDR 2
1 IIELNGQKPPLTYKRFQAIISRMELPKKPVSCVTSQQMEQCQAEIQENHDDTYGVPSLEEL 1
2 GFPTDGLGPAVWQGGEMEALARLDKHLERK 0
0 AWVANYERPRMNATSLLASPTGLSPYLRFGCLSCRLFYYRLWELYKK 0
0 VKRNNTPPLSLYGQLLWREFFYTAATNNPKFDRMEGNPICIQIPWDRNPEALAKWAEGKTGFPWIDAIMTQLRQEGWIHHLARHAVACFLTRGDLWVSWESGVR 0
0 VFDELLLDADFSVNAGSWMWLSCSAFFQQFFHCYCPVGFGRRTDPSGDYVR 2
2 RYLPQLKGFPSRYIYEPWNAPESVQKAAKCIIGVDYPKPIVNHAETSRLNIERMKQIYQQLSRYRGL 1
2 CLLASVPSCMEDLSSPMAETSMGQAGSVSST 1
2 GPKPLPCSPASPKRK LEATEEASREEHSKRARMAALPVPELAS----* 0

>CRY2_monDom Monodelphis domestica (opossum)
0 MAAAVVTMTAAAPAPAPSPEGASSVHWFRKGLRLHDNPALQAALRGARCVRCVYILDPWFAASSSVGINRWR 2
1 FLLQSLEDLDISLRKLNSRLFVVRGQPTDVFPRLFK 0
0 EWGVTRLTFEYDSEPFGKERDAAIVKMAKEAGVEVVTENSHTLYDLDR 2
1 IIELNGQKPPLTYKRFQAIISRMELPRKPVNSVTSQQMERCQAEIQENHDDAYGVPSLEEL 1
2 GFPTDGLGPAVWQGGETEALARLDKHLERK 0
0 AWVANYERPRMNAASLLASPTGLSPYLRFGCLSCRLFYYRLWELYKK 0
0 VKRNNTPPLSLYGQLLWREFFYTAATNNPKFDRMEGNPICIQIPWDRNPEALAKWAEGKTGFPWIDAIMTQLRQEGWIHHLARHAVACFLTRGDLWVSWESGVR 0
0 VFDELLLDADFSVNSGSWMWLSCSAFFQQFFHCYCP-GFGRRTDPSGDYVR 2
2 RYLPQLKGFPARYIYEPWNAPEPVQKAAKCIIGVDYPRPIVNHAETSRLNIERMKQIYQQLSRYRGL 1
2 CLLASVPSCLEDLSSPMVEASLGQAGAVSGP 1
2 GLKPLPCSPASPKRKLEATEEAPGEEHSKRARVARLPGSELAGKDV* 0

>CRY2_ornAna Ornithorhynchus anatinus (platypus)
0 ---------------------------------LHDNPALQAALRGARSVRCVYILDPWFAASSSVGINRWR 2
1 FLLQSLEDLDTSLRKLNSRLFVVRGQPTDVFPRLFK 0
0 EWGVTRLTFEYDSEPFGKERDAAIVKMAKEAGVEVVTENSHTLYDLDR 2
1 IIELNGQKPPLTYKRFQAIISRMELPKKPVSCVTSQQMEGCKAEIQDNHDDTYGVPSLEEL 1
2 GFPTDGLGPAVWQGGETEALARLDKHLERK 0
0 AWVANYERPRMNANSLLASPTGLSPYLRFGCLSCRLFYYRLWDLYKK 0
0 VKRNSTPPLSLYGQLLWREFFYTAATNNPRFDRMEGNPICIQIPWDRNPEALAKWAEGKTGFPWIDAIMTQLRQEGWIHHLARHAVACFLTRGDLWVSWESGVR 0
0 VFDELLLDADFSVNAGSWMWLSCSAFFQQFFHCYCPVGFGRRTDPSGDFIR 2
2 RYLPKLKAFPSRYIYEPWNAPESVQKAAKCVIGVDYPRPIVNHAETSRLNIERMKQIYQQLSRYRGL 1
2 CLLASVPSCVEDLSSAAAESGLGQASGSNIST 1
2 APRPPPPPYGPASPKRKLEAAEGLPGEELCKRPKVAGRPGPEPPGEDA* 0

>CRY2_galGal Gallus gallus (chicken) AJ396745 bursa 19456395 15459395
0 MAAAASPPRGFCRSVHWFRRGLRLHDNPALQAALRGAASLRCIYILDPWFAASSAVGINRWR 2
1 FLLQSLEDLDNSLRKLNSRLFVVRGQPTDVFPRLFK 0
0 EWGVTRLTFEYDSEPFGKERDAAIIKLAKEAGVEVVIENSHTLYDLDR 2
1 IIELNGNKPPLTYKRFQAIISRMELPKKPVSSIVSQQMETCKVDIQENHDDVYGVPSLEEL 1
2 GFPTDGLAPAVWQGGETEALARLDKHLERK 0
0 AWVANYERPRMNANSLLASPTGLSPYLRFGCLSCRLFYYRLWELYKK 0
0 VKRNSTPPLSLYGQLLWREFFYTAATNNPKFDRMEGNPICIQIPWDKNPEALAKWAEGKTGFPWIDAIMTQLRQEGWIHHLARHAVACFLTRGDLWISWESGVR 0
0 VFDELLLDADFSVNAGSWMWLSCSAFFQQFFHCYCPVGFGRRTDPSGDYVK 2
2 RYLPKLKGFPSRYIYEPWNAPESVQKAAKCIIGVDYPKPMVNHAETSRLNIERMKQIYQQLSRYRGL 1
2 CLLASVPSCVEDLSGPVTDSAPGQGSSTST 1
2 AVRLPQSDQASPKRKHEGAEELCTEELYKRAKVTGLPAPEIPGKSS* 0

>CRY2_taeGut Taeniopygia guttata (finch) FE716439 brain
0 --------------------------------------------IYILDPWFAATSAVGINRWR 2
1 FLLQSLEDLDNSLRKLNSRLFVVRGQPTDVFPRLFK 0
0 EWGVTRLTFEYDSEPFGKERDAAIVKLAKEAGVEVVIENSHTLYDLDR 2
1 IIELNGHKPPLTYKRFQAIISRMELPKKPVSTVISQQMETCKVDIQENHDDVYGVPSLEEL 1
2 GFPTDGLAPAVWQGGETEALARLDKHLERK 0
0 AWVANYERPRMNANSLLASPTGLSPYLRFGCLSCRLFYYRLWELYKK 0
0 VKRNSTPPLSLYGQLLWREFFYTAATNNPKFDRMEGNPICIQIPWDRNPEALAKWAEGKTGFPWIDAIMTQLRQEGWIHHLARHAVACFLTRGDLWISWESGVR 0
0 VFDELLLDADFSVNAGSWMWLSCSAFFQQFFHCYCPVGFGRRTDPSGDYVK 2
2 RYLPKLKGFPSRYIYEPWNAPESVQKAAKCIIGVDYPKPMVNHAETSRLNIERMKQIYQQLSRYRGL 1
2 CLLASVPSCVEDISGPVPDSASGQGCSTST 1
2 AVRLSQAEQASPKRKHEGAEEPCSEELYKRAKVTGLPTSEISGKSL* 0

>CRY2_anoCar Anolis carolinensis (lizard) XM_003214641
0 MAALPGPLGRCSVHWFRRGLRLHDNPALQAAIRDGGPVRCIYILDPWFAASSSVGINRWR 2
1 FLLQSLEDLDNSLRKLGSRLFVVRGQPTDVFPRLFK 0
0 EWRVTRLTFEYDSEPFGKERDAAIVKLAKEAGVEVITENSHTLYDLDR 2
1 IIELNGHKPPLTYKRFQTIISRMDLPKKPVASITHQQMEMCKTEIQDNHDETYGVPSLEEL 1
2 GFPTESLAPAVWLGGETEALTRLDKHLERK 0
0 AWVANYERPRMNANSLLASPTGLSPYLRFGCLSCRLFYYRLWELYKK 0
0 VKRNSTPPLSLYGQLLWREFFYTAATNNPKFDRMEGNPICIQIPWDRNPEALAKWAEGKTGFPWIDAIMTQLRQEGWIHHLARHAVACFLTRGDLWISWESGVR 0
0 VFDELLLDADFSVNSGSWMWLSCSAFFQQFFHCYCPVGFGRRTDPSGDYVR 2
2 RYLPKLKGFPSRYIYEPWNAPESVQKAAKCIIGVDYPKPMVNHAETSRLNIERMKQIYQQLSRYRGL 1
2 CLLASVPSCMEDLSNPVADTSSSHGNCIGT 1
2 ASRQTHCGQTSPKRKHDVVQEYKEELYKRAKVVASQFAENPRQELVHHEMGN* 0

>CRY2_xenTro Xenopus tropicalis (frog) NM_001088670 AY049035 CX389867 11533577 discrepancies
0 MEGKPSVSSVHWFRKGLRLHDNPALLSALRGANSVRCVYILDPWFAASSSGGVNRWR 2
1 FLLQSLEDLDTSLRKLNSRLFVVRGQPADVFPRLFK 0
0 EWGVSRLTFEYDSEPFGKERDAVIMKLAKEaGVEVVVENSHTLYDLDR 2
2 VIELNGHSPPLTYKRFQAIISRMELPRRPAPSVTRQQMEACRAEIKRNHDETYGVPSLEEL 1
1 GFHsEiKGpsIWPGGETEALARLDRHLERK 0
0 AWVANYERPRMNANSLLASPTGLSPYLRFGCLSCRLFYYRLKELYKK 0
0 VKKNSPPPLSLYGQLLWREFFYTAATNNPKFDQMEGNPICVQIPWDKNPKALAKWAEGKTGFPWIDAIMTQLRQEGWIHHLARHAVACFLTRGDLWNSWECGVK 0
0 VFDELLLDADFSVNAGSWMWLSCSAFFQQFFHCYCPVGFGRRTDPSGDYVR 2
2 RYLPVLKAFPSRYIYEPWSAPESVQKEAKCIIGIDYPKPIVNHAEASRMNIERMKQTYQQLSRYRGL 1
1 CILASVPSCMEDLGGPMADSSQNISE 1
2 AGKMAPPSHTSGESVLAAQYTAGI* 0

>CRY2_ranCat Rana catesbeiana (bullfrog) GO458565 AY256684
0 MEGPAVSSVHWFRKGLRLHDNPALLAALRGARCVRCVYILDPWFAASSSSSGGVNRWR 2
1 FLLQSLEDLDSSLRKLGSRLFVGRGQPADVFPRLFK 0
0 EWGVTRLTFQYYSEPFGKERDAAIMKLAKEAGVEVIVESSHTLYDLDK 2
2 IIELNGNSPPLTYKRFQAIVSRMELPRRPVPSITRQQMEKCRAEIKSTHDDTYGVPSLEEL 1
1 GFPRDNPGAAVWPGGETEALARLDRHLERK 0
0 AWVAHYERPRMNANSLLASPTGLSPYLRFGCLSCRLFYYRLRELYQKVKK 0
0 VKKNSPPPLSLFGQLLWREFFYTAATNNPKFDQMEGNPICVQIPWDKNPEALAKWTEGKTGFPWIDAIMTQLRQEGWIHHLARHAVACFLTRGDLWNSWECGVK 0
0 VFDELLLDADFSVNAGSWMWLSCSAFFQQFFHCYCPVGFGRRTDPSGDYVR 2
2 RYLPVLKGYPSRYIYEPWNAPESVQKEAKCIVGVDYPKPVVNHAEASRLNIERMKQTYQQLSRYRGL 1
1 CILASVPSSVEDLSGPMADPASSQQGSS 1
2 DPAPRLCAVDSPKRKHEDLDGELCKKARLQCVQEMERAAKDFL* 0

DASH cryptochrome-related sequences

DASH is a weakly related homologous protein in the same family as the photolyases and cryptochromes. It was identified only recently as active only on ssDNA repair, reportedly because of a barrier to flipping the damaged cyclobutane pyrimidine dimer dinucleotide out of dsDNA into its active repair site unless it is in a loop. This enzyme uses MTHF folate and FAD, activated by blue light.

CyrDASH.jpg

Although originally found in plants, surprisingly the DASH photolyase extends into fish, frogs, salamanders, turtle, lizard, finch, duck, and budgerigar. Using blastx on the syntenic region in gallinaceaous birds (chicken and turkey) establishes that they have a highly degenerate multi-exonic pseudogene at the expected location and orientation. It is not possible to date this more precisely nor determine whether pseudogenization occurred in a common ancestor or independently on account of domestication.

Platypus does not have any pseudogene debris at the expected location but the assembly has a break here. Marsupials and placentals again appear never to have had this enzyme. The loss of this photoenzyme is very similar to the [Opsin_evolution:_trichromatic_ancestral_mammal|massive loss of opsins] that occured early in mammalian evolution -- which GT Walls in 1942 [attributed] to mammals experiencing a sustained period of deep nocturnality where these systems did not need to function (no UV damage) and indeed could not function (insufficient blue light) and so were lost (ie did not give rise to a non-catalytic cryptochrome of altered functionality). An analogous event may have occurred after the great oxygenation event gave rise to a stratospheric ozone protective layer at 2.4 byr but reached an even higher lever during the early Cambrian (based indirectly on oxygen levels). The first land plants and animals would have experienced greatly increased levels of UV damage however and that too may correlate with evolutionary events.

>DASH_taeGut Taeniopygia guttata (finch) ABQF01044665 ABQF01044669 ABQF01044671 synteny: ACAA1 DASH MYD66 OXSR1
0 MSGTAGTAICLLRCDLRAHDNQ 0
0 QVLHWAQHNADFVIPLYCFDPRHYLGTHCYRLPKTGPHRLRFLLESVKDLRETLKKKGS 2
1 TLVVRKGKPEDVVCDLITQLGSVTAVVFHEE 0
0 ATQEELDVEKGLCQVCRQHGVKIQTFWGSTLYHRDDLPFRPIDR 2
1 LPDVYTHFPKGLESGAKVRPTLRMADQLKPLAPGLEEGSIPTMEDFGQK 1
2 DPVADPRTAFPCSGGETQALMRLQYYFWDT 0
0 NLVASYKETRNGLVGMDYSTKFAPW 2
1 LALGCISPRYIYEQIQKYERERTANESTYW 2
1 VLFELLWRDYFRFVALKYGRRIFSLR 1
2 EGKTGVPFVDANMRELSATGFMSNRGRQNVASFLTKDLGLDWRMGAEWFEYLL 0
0 VDYDVCSNYGNWLYSAGIGNDPRDNRKFNMIKQGLDYDGN 0
0 GDYVRLWVPELQGIKGADIHTPWALSSAALSQAGVTLGETYPQPVVTAPEWSRHIHRRP 0
0 GGSPHPRGRRGPAQRKDRGIDFYFSRKKDAC* 0

>DASH_anaPla Anas platyrhynchos (duck) scaffold1769
0  0
0 QVLHWAASNADYLIPLYCFDPRHYAGTHCYGFPKTGPHRLRFLLESVKDLRETLKKKGS 2
1 TLVVRKGKPEDVVRDLITQLGCVGVVAFHEE 0
0 ATQEELDVEKELCQVCEQHGVKVQPFWAATLYHRDDLPFGPIAR 2
1 LPDVYTQFRKAVEAEAKVRPALQLPDQLKPLAPGVEEGCIPTMEDLGQK 1
2 DPGTDPRTAFPCCGGETQALARLQYYFWDT 0
0 NLVASYKETRNGLIGMDYSTKFAPW 2
1 LALGCISPRYIYEQLRKYEKERGANDSTYW 2
1 VLFELLWRDYFRFVALKHGRRIFSVR 1
2 EGKTGVPFVDANMRELAATGFMSNRGRQNVASFLTKDLGLDWRMGAEWFEHLL 0
0 VDYDVCSNYGNWLYSAGVGNDPRDKRKFNVIKQGLDYDGN 0
0 GDFVRLWLPELQGIAGADAHAPWALSSTALRQAGIILGQTYPQPLVRAPEWSRHINQRL 0
0 GRSPHPRGRRGPADAPAQRKDRGIDFYFSRKKDE* 0

>DASH_melGal Meleagris gallopavo (turkey) ADDD01036185 syntenic pseudogene
0  0
0  2
1  0
0  2
1  DVYTNL*KAVESEVKVWPALQRADQLKPLA-GSGRKMYPYNKGFG   1
2  0
0  LFASYKEIWSGLTGADNSTKFAPW 2
1 LVLDCLSP*CIFSQVQKYIKERAANQSTFW 2
1 VFELLWWDCF*FVPLKYGRRIFSL 1
2  0
0 LKVDYNVPNN*VT*LYSADIGNHPKENRKFNMIKEGPNDDG 0
0 VPELQGIKGPDIHSPWALNSASVFQVGGTLVETYPQPAV 0
0 * 0

>DASH_galGal Gallus gallus (chicken) syntentic pseudogene, numerous indels, frameshifts, internal stops
0  0
0  2
1 MVVRKGKLEDMVHDVITSLGCVGVVAFHEE 0
0  2
1 IQPDVYTNF*KAVESEVKTWPALQRADQLKPLAGG&^EEGCIPTTEDLGQK 1
2 DPGTDPQTAF-LGFNETAAL          0
0 LLFASYNETWSGLIGVD*STKFAPW 2
1 LVLGCLSP*YIFSQIGKYVKERAANHST*W 2
1 AVFELLWWDCF*FVALKYGRRILSLK 1
2                                    LGLDWRMGAEWFEYLL 0
0 VDYNVFSN*STWLYSAGIGNHPKDNRKFNVIKQGPDYDGN 0
0 GDCIQLRVTELQGMKEADIHSPWALNSATLSQVGVTLGKTYPQVQSDSP^EWSRQIRQRA 0
0 GRSPHPKGRRGPAHSPLQHKERGTDCFSLKK* 0

>DASH_melUnd Melopsittacus undulatus (budgerigar) AGAI01061648 
0 msgtSARTAICLLRCDLRAHDNQ 0
0 QVLHWAQSNAEFVVPLYCFDPRHYLRTHWYGFPKTGPYRLRFLLESVKDLRETLKKKGS 2
1 TLVVRKGKPEDVVRDLITQLGSVSAVVFHEE 0
0 ATQEELDVENELCQVCSQHGVKVYTFWASTLYHRDDLPFRPIAR 2
1 LPDVYTHFRKAVESEAKVRPTLRMADQLQPLAPGVEEGCIPTMEDFGQK 1
2 DPDTDPRTAFPGSGGETQALMRLQYIYFWDT 0
0 NLVASYKEVRNGLVGMDYSTKFAPW 2
1 LALGCISPRYIYEQIKKYERERTANQSTYW 2
1 VLFELLWRDYFRFVALKYGRRIFSLR 1
2 EGKTGVPFVDANMRELAATGFMSNRGRQNVASFLTKDLGLDWRMGAEWFEYLL 0
0 VDYDVCSNYGNWLYSAGVGNDPRDNRKFNMVKQGLDYDGN 0
0 GDYVRLWVPELQGIKGADIHTPWALSSAALSQAGVTLGETYPQPIVTAVEWSRHISQRP 0
0 GRSLHPRGSRRPAHSPVQHKDRGIDFYFSRKKDA* 0

>DASH_anoCar Anolis carolinensis (green anole) XM_003221869 14 exons
0 MASSLPRTALCLLRNDLRCHDNE 0
0 VLHWAQSHADRIVPLYCFDPRHYAQTYHYNFPKTGPFRLRFLLESVKDLRETLKKKGS 2
1 NLVVRKGKPEDVVRDLIIQLGSVASVSFHEE 0
0 ATKEELDVEKALIRVCTEHGVEVQTFWGSTLYHRQDLPFKHISQ 2
1 LPDVYTQFRKAVESQARVRPVLKMEGQMKSLPPEIEEGNIPSLEDFGMT 1
2 EPLRDPRSAFLCSGGETQALMRLQHYFWET 0
0 NLVASYKETRNGLIGLDYSTKFAPW 2
1 LALGCISPRYIYDQIQKYEKERTANQSTYW 2
1 VLFELAWRDYFRFVALKYGRKIFFPR 1
2 GLQDKDISWKKDPKLFDAWK 0
0 EGRTGVPFVDANMRELATTGFMSNRGRQNVASFLTKDLGLDWRMGAEWFESLL 0
0 VDYDVCSNYGNWLYSAGIGNDPRENRKFNMIKQALDYDGN 0
0 GDYARLWVPELQCIRGGDVHTPWALSNGALSQAGVSLGSSYPVPIIKAPEWGRHINQKPVSM 0
0 SNQGPKGRKGPSHTPKQHKNRGVDFYFSHKKDLS* 0

>DASH_chrPic Chrysemys picta (turtle) AHGY01416294 first exon off contig
0  0
0 VLRWAQNNADYVIPLYCFDPRQYLRTYYYGFPKTGPHRLKFLLESVKDLRQTLKKKGS 2
1 NLVVRKGNPEDVVHDLITQLGSVTAVAFHEE 0
0 ATKEELDVEKALQRVCVQHGVKIQTFWASTLYHRDDLPFRHISR 2
1 LPDVYTQFRKAVEAQAKVRPTVQMPDQLKPLAPGVEDGCIPVPEEFGQK 1
2 DPLTDPRTAFPCCGGETQALMRLQHYFWDT 0
0 NLVASYKETRNGLIGIDYSTKFAPW 2
1 LALGCISPRYIYEQIRKYEKERTANQSTYW 2
1 VIFELLWRDYFRFVALKYGTRIFLLK 1
2 GLQDKEVPWKKDPKLFDAWK 0
0 EGRTGVPFVDANMRELAATGFMSNRGRQNVASFLTKDLGLDWRMGAEWFEYLL 0
0 VDYDVCSNYGNWLYSAGIGNDPRENRKFNMIKQGLDYDSN 0
0 GDYVRLWVPEIQCVKGGEIHTLWALSNAALSQAGIALGETYPLPVVLAREWSRHINQKP 0
0 RDHPPRGRKDPSDTPRQHKDRGMDFYFSRNKDLS* 0

>DASH1_xenTro Xenopus tropicalis (frog) AAMC01075730 NM_001090969 15147276
0 MCVPSRVIICLLRNDLRLHDNE 0
0 VLHWAHRNADQIVPLYCFDPRHYVGTHYFNFPKTGPHRLKFLLESVRDLRITLKKKGS 2
1 NLLLRRGKPEEVIEDLVKQLGNVSAVTLHEE 0
0 ATKEETDVESAVKQACTRLGIKYQTFWGSTLYHREDLPFRHISS 2
1 LPDVYTQFRKAVETQGKVRPTFQMPDKLKPLPSGLEEGSVPSHEDFDQQ 1
2 DPLTDPRTAFPCSGGESQALQRLEHYFWET 0
0 NLVASYKDTRNGLIGLDYSTKFAPW 2
1 LALGCVSPRYIYEQIGKYEKERTANQSTYW 2
1 VIFELLWRDYFRFVALKYGRRIFFLR 1
2 GLQDKDIPWKRDPKLFDAWK 0
0 EGRTGVPFVDANMRELAMTGFMSNRGRQNVASFLTKDLGIDWRMGAEWFEYLL 0
0 VDYDVCSNYGNWLYSAGIGNDPRENRKFNMIKQGLDYDSG 0
0 GDYIRLWVPELQQIKGGDAHTPWALSNASLAHANLSLGETYPYPIVMAPEWSRHINQKPAGS 0
0 WEKSARRGKGPSHTPKQHKNRGIDFYFSRNKDV* 0

>DASH2_xenTro Xenopus tropicalis (frog) XM_002938001
0 MAARARVIICLLRNDLRLHDNE 0
0 VLHWAHRNADQIVPLYCFDPRHYGGTHYFNFPKTGPHRLKFLLESVQDLRNTLKERGS 2
1 NLLLRRGKPEEIIAGLVKQLGNVSAVTLHEE 0
0 ATKEETDVESAVRRVCTQLGVRYQTFWGSTLYHREDLPFRHISS 2
1 LPDVYTQFRKAAETQGKVRSTFQMPDRLKPLPSGLEEGSVPTHQDFDQQ 1
2 DPLTDPRSAFPCCGGETQALQRLHHYFWET 0
0 NLVASYKDTRNGLIGIDYSTKFAPW 2
1 LALGCISPRYIYEQIRKYEKERTANQSTYW 2
1 VIFELLWRDYFRFVALKYGRRIFFLR 1
2 GLQDKDVPWKKDPKLFDAWK 0
0 EGRTGVPFVDANMRELAMTGFMSNRGRQNVASFLTKDLXIDWRLGAEWFEYLL 0
0 VDYDVCSNYGNWLYSAGIGNDPRENRKFNMIKQGLDYDAG 0
0 GDYIRLWVPELQQIKGGDAHTPWALSTASLAHSNVSLGETYPYPIVMAPEWSRHINQKPSGS 0
0 WETSARRGKGPSHTPKQHRNRGIDFYFSRNKNV* 0

>DASH_hymCut Hymenochirus curtipes (frog)
1  QMPKLKPLPDGLEEGKVPTYEEFDQE 1
2 DPLTDPRTAFPCSGGETQALQRLHHYFWDT 0
0 NLVPPYKDTRNGLIGLDYSTKLAPW 2
1 LALGCVSPRFIYEQIKKYEQERTANQSTYW 0
0 VIFELLWRDYFRFVALKYGRRIFFLR 1
2 GLAHTNV

>DASH_ambMex Ambystoma mexicanum (axolotl) CO785483
0 MSVQARTIICLLRNDLRFHDNE 0
0 VLLWALKNAERIVPLYCFDPRHYVGTHNYNFPKTGPHRLKFLLESVKDLRETLKKKGS 2
1 NLLVRKGKPEDVIQELLKQLGSVSAVAFHNE 0
0 VTKEELDVEAAVKQVCvqhgGKIQTFWGSTLYHRDDLPFRHISR 2
1 LPDVYTQFRKGVESQGTSAATLQMPQKVPPLPSGLE 

>DASH_oreNil Oreochromis niloticus XM_003439198
0 MSSSRTVICLLRNDLRLHDNE 0
0 LFHWAQRNAEHIVPLYCFDPTHYVGTYNYSLPKTGPFRLRFLLEGIRDLRNTLINKGS 2
1 NLVVRRGKPEEVVADLIRQLGSVSSVAFHEE 0
0 VTSEELNVEKRVKDVCAQMKVKVHTCWGSTLYHRDDLPFPHMSR 2
1 LPDVYTQFRKAVESEGRVRPVFSTPEKLNPLPPGLEEGAIPTAEDLQQT 1
2 EPVTDPRSAFPCGGGESQALARLKHYFWDT 0
0 DAVATYKETRNGLIGVDYSTKFSPW 2
1 LAMGCISPRYIYHQIKQYEKERTANQSTYW 2
1 VIFELLWRDYFRFVSVKYGNRIFQVK 1
2 GLQDKSVPWKKDMKLFDAWK 0
0 EGRTGVPFVDANMRELAATGFMSNRGRQNVASFLTKDLGLDWRMGAEWFESLL 0
0 IDHDVCSNYGNWLYSAGIGNDPRENRKFNMIKQGLDYDNN 0
0 GDYVRGWVPELQNIRGGDVHTPWALSTAVLAHAHVTLGDTYPAPIVTAPEWSRHVNKKAGGT 0
0 GPSPRGKKGPSHTPKQHRDRGIDFYFSRSKNL* 0

>DASH_danRer Danio rerio (zebrafish) NM_205686
0 MSASRTVICLLRNDLRLHDNE 0
0 VFHWAQRNAEHIIPLYCFDPRHYQGTYHYNFPKTGPFRLRFLLDSVKDLRALLKKHGS 2
1 TLLVRQGKPEDVVCELIKQLGSVSTVAFHEE 0
0 VASEEKSVEEKLKEICCQNKVRVQTFWGSTLYHRDDLPFSHIGG 2
1 LPDVYTQFRKAVEAQGRVRPVLSTPEQVKSPPSGLEEGPIPTFDSLGQT 1
2 EPLDDCRSAFPCRGGETEALARLKHYFWDT 0
0 NAVATYKETRNGMIGVDFSTKFSPW 2
1 LALGCISPRYIYEQIKKYEVERTANQSTYW 2
1 VIFELLWRDYFKFVALKYGNRIFYMN 1
2 GLQDKHVPWKTDMKMFDAWK 0
0 EGRTGVPFVDANMRELALTGFMSNRGRQNVASFLTKDLGLDWRLGAEWFEYLL 0
0 VDHDVCSNYGNWLYSAGIGNDPRENRKFNMIKQGLDYDNN 0
0 GDYVRQWVPELRGIKGGDVHTPWTLSNSALSHAQVSLNQTYPCPIITAPEWSRHVNNKS 0
0 SGPSSSKGRKGSSYTARQHKDRGIDFYFSKNKHF* 0

Fish cryptochrome sets

The situation in ray-finned fish is quite complicated because of gene duplication with retention. The full set of cryptochromes in some model species have been determined and those are predominantly what is provided here, using that nomenclature for the moment.


>CRY1A_danRer Danio rerio (zebrafish) BC134838
MVVNTVHWFRKGLRLHDNPSLRDSILGAHSVRCVYILDPWFAGS
SNVGISRWRFLLQCLEDLDASLRKLNSRLFVIRGQPTDVFPRLFKEWNINRLSYEYDS
EPFGKERDAAIKKLANEAGVEVIVRISHTLYDLDKIIELNGGQSPLTYKRFQTLISRM
EAVETPAETITAEVMGPCTTPLSDDHDEKFGVPSLEELGFDTEGLSSAVWPGGETEAL
TRLERHLERKAWVANFERPRMNANSLLASPTGLSPYLRFGCLSCRLFYFKLTDLYRKV
KKNSSPPLSLYGQLLWREFFYTAATNNPRFDKMEGNPICVQIPWDKNPEALAKWAEGR
TGFPWIDAIMTQLRQEGWIHHLARHAVACFLTRGDLWISWEEGMKVFEELLLDADWSV
NAGSWMWLSCSSFFQQFFHCYCPVSFGRRTDPNGDYIRRYLPVLRGFPAKYIYDPWNA
PESVQKAAKCIIGVHYPMPMVHHAEASRLNIERMKQIYQQLSCYRGLGLLAMVPSNPN
GNGENSTSLMGFKTGDMTKEVTTPSGYQMPPTSQGEWHGRTMVYSQGDQQTSSIMTSQ
GFGNNGSTMCYRQDAQQITGRGLHSSIIQTSGKRHSEESGPTTVSKVQRQCSS

>CRY1B_danRer Danio rerio (zebrafish) BC044558
MVVNTVHWFRKGLRLHDNPSLRDSIKGADNLRCVYILDPWFAGS
SNVGISRWRFLLQCLEDLDASLRKLNSRLFVIRGQPTDVFPRLFKEWKISRLSYEYDS
EPFGKDRDAAIRKLATEAGVEVFVRISHTLYDLDKIIEFNGGQSPLTYKRFQTLISRM
DPVEMPAETITAEIMGKCSTPVSDDHDDKFGVPSLEELGFETEGLSTAVWPGGETEAL
TRLERHLERKAWVANFERPRMNANSLLASPTGLSPYLRFGCLSCRLFYFKLTDLYRKV
KKNSTPSLSLYGQLLWREFFYTAATNNPHFDKMEFNPICVQIPWDRNPEALAKWAEGQ
TGFPWIDAIMTQLRQEGWIHHLARHAVACFLTRGDLWISWEEGMKVFEELLLDADWSV
NAGSWMWLSCSSFFQQFFHCYCPVGFGRRTDPNGDYIRRYLPILRGFPAKFIYDPWNA
PESVQKVAKCIIGVHYPKPMVNHAEASRINIERMKQIYQQLSCYRGLGLLATIPSNTA
NNEDSNGAGPSSGDTQESTHITVHTLPASSQSEFPAFAVSCGQQLVNSVQPQPGYSGA
GMVGQAHKQTQRVRGMTAFKRHGEDRTTDFPSKIQRNDGI

>CRY2B_danRer Danio rerio (zebrafish) BC164795
MSVNSVHWFRKGLRLHDNPALLEALNGADTLRCVYFLDPWFAGA
SNLGVNRWRFLLQSLEDLDASLRKLNSCLFVIRGQPADIFPRLFKEWKVSRLTFEFDS
EPFGKERDAAIKKLACEAGVEVIVKISHTLYDLDRIIELNGGQSPLTYKRFQTLVSSM
EPPDPPLSSPDRGMMGKCVTPISENHRDKYGVPLLEELGFDTEGLAPAVWPGGESEAL
KRMERHLGPDSTVAWQENFERPKMNASPLMASPLGLSPYLRFGCLSCRLFYCKLTQLY
KKVKKNMNPSISLYDKILWREFFYTAATNNPRFDRMEGNPICIRIPWDRNAEALAKWA
EAKTGFPWIDAIMMQLRQEGWIHHLARHAVACFLTRGDLWISWEEGMKVFEELLLDAD
WSVNAGSWLCHSCSSFFQQFFHCYCPVGFGRRIDPNGDFIRRYLPVLRDFPAKYIYDP
WNAPHDVQLAAKCVIGVDYPKPMVNHAEASRLNIERMRQIYQQLSRYRGLSLLATVPS
NHIEDAAANVNRGAMAPPTRRKTRNDASSYTGVRREQPGPSGAKHRHRHSLSHRPSPY
ATQSELTDHNHEFAVPQQPGRVSWPNVGGTGKKEGEAEHNCCRGDNGPSSSALKAQQQ
DNERREDAEGVAFST


>CRY2A_danRer Danio rerio (zebrafish) BC095305
MAPNSIHWFRKGLRLHDNPALQEAVRGADTVRCVYFLDPWFAGS
SNLGVNRWRFLLQCLDDLDSNLRKLNSRLFVVRGQPANVFPRLFKEWKISRLTFEYDS
EPFGKERDAAIKKLAMEAGVEVIVKTSHTLYNLDKIIELNGGQPPLTYKRFQTLISRM
DPPEMPVETLSNSIMGCCVTPVSEDHGDKYGVPSLEELGFDIEGLPSAVWPGGETEAL
TRIERHLERKAWVANFERPRMNANSLLASPTGLSPYLRFGCLSCRLFYFKLTDLYRKV
KKTSTPPLSLYGQLLWREFFYTAATTNPRFDKMEGNPICVRIPWDKNPEALAKWAEAK
TGFPWIDAIMTQLRQEGWIHHLARHAVACFLTRGDLWISWEEGMKVFEELLLDADWSV
NAGSWMWLSCSSFFQQFFHCYCPVGFGRRTDPNGDFIRRYLPILRGFPAKYIYDPWNA
PDSVQAAAKCIIGVHYPKPMVNHAEASRLNIERMKQIYQQLSRYRGLGLLASVPSTHN
GNGNGMAYSPGEQQSGTNTPAPAVSSGSVASGNRSGSILLNFDSEEHQGPSGIQQQHQ
QQQQQQQQQQLGYHHMPDSGHNSRFYKSNVSHDMAGHLLHKGGSVTGKRERESERDLD
GEDESLSTSHKLQRQIAEVTSVYASSGNQSSMRS


>CRY3_danRer Danio rerio (zebrafish) 
MVVNSVHWFRKGLRLHDNPALQEALNGADTVRCVYILDPWFAGS
ANVGVNRWRFLLESLEDLDTSLRKLNSRLFVVRGQPTDVFPRLFKEWNVTRLTFEYDS
EPYGKERDAAIIKMAQEYGVETVVRNTHTLYNPDRIIEMNNHSPPLTFKRFQAIVNRL
ELPRKPLPTITQEQMARCRTQISDNHDEHYGVPSLEELGFRTQGDSLHVWKGGETEAL
ERLNKHLDRKAWVANFERPRISGQSLFPSPTGLSPYLRFGCLSCRVFYYNLRDLFMKL
RRRSSPPLSLFGQLLWREFFYTAGTNNPNFDHMEGNPICVQIPWDHNPEALAKWAEGR
TGFPWIDAIMTQLRQEGWIHHLARHAVACFLTRGDLWISWESGMKVFEELLLDADWSV
NAGSWMWLSCSAFFQQFFHCYCPVGFGRRTDPSGDYIRRYIPKLKDYPNRYIYEPWNA
PESVQKAANCIVGVDYPKPMINHAESSRLNIERMKQVYQQLSHYRGLSLLASVPTIQE
EAEPPMSDDSQASSSSTGQASSPPHLSITAPSTPPLSESSSPNSSPTASTSVPHTQRK
RVRPSETPSKQKTKVKHTSQARGLELKMDDKQ

>CRY4_danRer Danio rerio (zebrafish) BC164413
MSHRTIHLFRKGLRLHDNPSLLGALASSSTLYPVYVLDRVFLQG
AMHMGALRWRFLLQSLEDLDTRLRAIGSRLFVLCGSTANILRELVAQWGITQISYDTE
VEPYYTRMDKDIQTVAQENGLQTYTCISHTLYDVKRIVKANGGSPPLTYKKFLHVLSV
LGEPEKPARDVSIEDFQRCVTPVDVDRVYAVPSLADLGLQVEAEVLWPGGESHALQRL
EKHFQSQGWVANFSKPRTIPNSLLPSTTGLSPYLSLGCLSVRTFYHRLNSIYAQSKNH
SLPPVSLQGQVLWREFFYTVASATPNFTKMEGNSICLQIDWYHDPERLEKWRTAQTGF
PWIDAIMTQLRQEGWIHHLARHAVACFLTRGDLWITWEEGMKVFEEFLLDADYSVNAG
NWMWLSASAFFHKYTRIFCPVRFGRRTDPQGEYLRKYLPVLKNFPSQYIYEPWKAPED
VQLSAGCIIGKDYPRPIVSHIEASQRNLALMRQVRTEQQTTAELTRDVADDPMEAGLK
RELREEEGLLEEAESQCTSKRFSGSSDHKSRPCSWTPETLQLSELSGEVM

>CRY5_danRer Danio rerio (zebrafish) BC044204
SCYKTQSRAHVIRRLCGGLHSPKATTMSHNTIHWFRKGLRLHDN
PALIAALKDCRHIYPLFLLDPWFPKNTRIGINRWRFLIEALKDLDSSLKKLNSRLFVV
RGSPTEVLPKLFKQWKITRLTFEVDTEPYSQSRDKEVMKLAKEYGVEVTPKISHTLYN
IDRIIDENNGKTPMTYIRLQSVVKAMGHPKKPIPAPTNEDMRGVSTPLSDDHEEKFGI
PTLEDLGLDTSSLGPHLFPGGEQEALRRLDEHMERTNWVCKFEKPKTSPNSLIPSTTV
LSPYVRFGCLSARIFWWRLADVYRGKTHSDPPVSLHGQLLWREFFYTTAVGIPNFNKM
EGNSACVQVDWDNNPEHLAAWREARTGFPFIDAIMTQLRQEGWIHHLARHAVACFLTR
GDLWISWEEGQKVFEELLLDSDWSLNAGNWQWLSASTFFHQYFRVYSPIAFGKKTDKH
GDYIKKYLPVLKKFPTEYIYEPWKAPRSVQERAGCIVGKDYPRPIVDHEVVHKKNILR
MKAAYAKRSPEDKTINKGEKRKASPSIKELVQKKAKR

>CRYDASH_danRer Danio rerio (zebrafish) BC098514
MSHRTIHLFRKGLRLHDNPSLLGALASSSALYPVYVLDRVFLQG
AMHMGALRWRFLLQSLEDLDTRLQAIGSRLFVLCGSTANILRELVAQWGITQISYDTE
VEPYYTRMDKDIQTVAQENGLQTYTCVSHTLYDVKRIVKANGGSPPLTYKKFLHVLSV
LGEPEKPARDVSIEDFQRCVTPVDVDRVYAVPSLAHLGLQVEAEVLWPGGESHALQRL
EKHFQSQGWVANFSKPRTIPNSLLPSTTGLSPYLSLGCLSVRTFYHKYTRIFCPVRFG
RRTDPQGEYLRKYLPVLKNFPSQYIYEPWKAPEDVQLSAGCIIGKDYPRPIVSHIEAS
QRNLALMRQVRTEQQTTAELTRDVADDPMEAGLKRELREEEGLLEEAESQCTSKRFSG
SSDHKSRPCSWTPETLQLSELSGEVM

>CRY1A_phrAnd Phreatichthys andruzzii (Somalian cavefish) GQ404476 21909239
                  MVVNTVHWFRKGLRLHDNPSLRDSIQGAHTVRCVYILDPWFAGSSNVGISRWR
FLLQCLEDLDASLRKLNSRLFVIRGQPTDVFPRLFK
EWNITRLSYEYDSEPFGKERDAAIKKLANEAGVEVIVRISHTLYDLDK
IIELNGGQSPLTYKRFQTLISRMEAVETPAETITAEVMGTCTTPVSDDHDEKFGVPSLEEL
GFDTEGLSSAVWPGGETEALTRLERHLERK
AWVANFERPRMNANSLLASPTGLSPYLRFGCLSCQLFYFKLTDLYRK
VKKNSSPPLSLYGQLLWREFFYTTATNNPRFDKMEGNPICVQIPWDKNPEALAKWAEGRTGFPWIDAIMTQLRQEGWIHHLARHAVACFLTRGDLWISWEEGMK
VFEELLLDADWSVNAGSWMWLSCSSFFQQFFHCYCPVSFGRRTDPNGDYIR
RYLPVLRGFPAKYIYDPWTAPESVQKAAKCIIGVHYPKPMVHHAEASRLNIERMKQIYQQLSCYCGLGLLATVPSNPN
GNGENSTTLKGFQTGDVTKEFTAPSGYQMPPTSQGEWHGRTMGYSQGDHQTNMPPQGFANSSTTMCYRQDSQQISGPAVQPGRGLHCSTIQTYGKRHSEESGPATGSKVQRQSIS

>CRY2B_phrAnd Phreatichthys andruzzii (Somalian cavefish) GQ404479
EGNPICIRIPWDRNPEALAKWAEAKTGFPWIDAIMTQLRQEGWIHYLARNAVTCFLTRGDLWINWEEGMKIFEELLLDADWSVNAGSWLCHSCSSFFQQFFH
CYCPVGFGRRIDPNGDFIRCYLPVLRDFPAKFIYDPWNAPDDVQRAAKCVIGMDYPKPMVNHAEASRLNIERMRQIYQ

>CRY3_phrAnd Phreatichthys andruzzii (Somalian cavefish) GQ404480
                                  EALNGADTVRCVYILDPWFAGSANVGVNRWR
FLLDSLEDLDTSLRKLNSRLFVVRGQPTDVFPRLFK
EWNVTRLTFEYDSEPYGKERDAAIIKMAQEYGVQTVVRNTHTLYNPDR
IIEMNNHSPPLTFKRFQAIVNRLELPRKPLPTITQEQMARCRTQISDNHDEHYGVPSLEEL
GFKTQRDSSHVWKGGETEAMERLNKHLDRK
GWVANFERPRIITAQSLFASPTGLSPYLRFGCLSCRVFYYNLRELFMK
LRRRSSPPLSLFGQLLWREFFYTAGTNNPNFDRMEGNPICVQIPWDHNPEALAKWAEGRTGFPWIDAIMTQLRQEGWIHHLARHAVACFLTRGDLWISWESGMK
VFEELLLDADWSVNAGSWMWLSCSAFFQQFFHCYCPVGFGRRTDPSGDYIR
RYIPKLKDYPNCYIYEPWNAPESVQKAANCIVGVDYPKPMINHAESSRLNIERMKQVYQQLSHYRG

>CRY4_phrAnd Phreatichthys andruzzii (Somalian cavefish) GQ404481
LHVLTVLGEPEKPVRDVSAEDFLRCMTPAEADHEKTYAVPSLADLGLEVEFDVLWPGGETHALQRLDKHFQSQGWVTSFSKTRTVPNSLLPSSTGLSPYLSL
GCLSVRTFYHQLSSVYAQSKNHSLPPLSLQGQVLWREFFYTVASSTPNFTKMEGNPICLQIQWYHDPEALEKWRTAQTGFPWIDAIMTQLRQEGWIHHLARHAVACFLTRGDLWIS
WEEGMKVFEELLLDADYSINAGNWMWLSASAFFHKYTRIFCPVRFGRRTDPQGQYL

>CRY5_phrAnd Phreatichthys andruzzii (Somalian cavefish) GQ404482
            MSHNSIHWFRKGLRLHDNPALLAALKDCRHIYPL
FLLDPWYPNNTHIGINRWRFLIEALKDLDSSLKKLNSRLFVVSGPPAEVLPKLFEKWKITRLTFEVDT
EPYSQSRDKEVMKLAEENGVEVIPKISHTLYNIDRIIEENNGKPPMTYVRFLSVVNAIGSPKKPVPAPTKEDMKGVSTPFFEDHEEEFRIPTLEDLGLDTSSLGPNLFPGGEQEAL
RRLDEHMERTTWVCKFEKPQTSPNSIIPSTTVLSPYIRFGCLSARTFWWRLADVYRGKQHSEPPVSLHGQLLWREFFYTTAVGIPNFNRMEGNRHCVQVDWDNNPEHLAAWREART
GFPFIDAIMTQLCQEGWIHHLARHAVACFLTRGDLWISWEEGQKVFEELLLDADWSLNAGNWQWLSASAFFHQFFRV
>CRY2_tetNig Tetraodon nigroviridis (pufferfish)
0 LTA-EVSGAD--RARVM--DRGSSVHWFRKGLRLHDNPALQEALSGADSLRCVYVLDPWFAGAANVGINRWR 2
1 FLLEALEDLDCSLKKLNSRLFVVRGQPTDVFPRLLK 0
0 EWKVTRLTFEYDPEPYGKERDGAIIKMAQQFGVETIVRNSHTLYNLDR 2
2 IVEMNNNSPPLTFKRFQTIVSRLELPRRPLPSVTQQQMDKCGTPVADNHDQLYSIPSLEEL 1
1 GFRTGGLAPAVWRGGESEALERLRKHLEKK 0
0 VWVSHLEHSRANTCSLYASPAGLSPYLRFGCLSCRVFYYNLREHYIR 0
0 LCKGCSPPLSLFGQLLWREFFYTAATNNPNFDRMAGNPICVQIPWDQNPEALAKWAEGRTGFPWIDAIMTQLRQEGWIHH-ARRAVACFLTRGDLWISWEC---
0 VFEELLLDADWSVNAGSWMWLSCSAFFQQFFKCYCPVGFGRRTDPSGDYIR 2
2 RYIPILKDYPNRYIYEPWNAPEAVQKAANCVVGVDYPRPMINHAEGSRLNIERMKQVYQQLSHYRAL 1
1 -LRAPVPS-VEGCSRPPPESPLSQAGGESQA 1
2 ----------------------------------------------- * 0

>CRY2_gasAcu Gasterosteus aculeatus (stickleback)
0 -------------------VTN---HWFRKGLRLHDNPSLADSLLGADTVRCVYILDPWFAGSSNVGIHRWR 2
1 FLLQSLQDLDSSLRKHHSRLFVIRGQPTDVFPRLFK 0
0 EWNTSRLSYEYDSEPFGKERDAAIRKLACEAGVEVTVRVSHTLYDPDR 2
1 IIELNGGQSPLTYKRFQTLIGRMESPRSP-ADDV---MGKCRTPMEDHDDK--GVPSLEEL 1
1 GFDTEGLSSAVWPGGETEALARLERHLERK 0
0 AWVANFERPRMNANSLLASPTGLSPYLRFGCLSCRLFYFKLTDLYMK 0
0 VKKNSSPPLSLYGQLLWREFFYTAATNNPRFDKMESNPICVQIPWDRDPEALAKWAEGRTGFPWIDAIMTQLRREGWIHHLARHAVACFLTRGDLWIGWEE---
0 VFEELLLDADWSVNAGSWMWLSCSSFFQQFFHCYCPVGFGRRADPNGDYIR 2
2 RYLPILRGFPAEYIYDPWNAPESVQKAAECVIGVHYPKPMVNHAHASRLNIERMKQIYQQLSCCRGF 1
1 ------------------------------- 1
2 ----------------------------------------------- * 0

>CRY2_oryLat Oryzias latipes (medaka)
0 -----------------------SVHWFRKGLRLHDNPALQEALNGADTVRCVYILDPWFAGAANVGINRWR 2
1 FLLEALEDLDCSLKKLNSRLFVVRGQPTDVFPRLFK 0
0 EWNVTRLTFEYDPEPYGKERDGAIIKMAQEFGVETVVRNSHTLYNLDR 2
1 IIELNNNSPPLTFKRFQTIVSRLELPRRPLPAITQQQMDSCQRQIGDNHDQLYSIPSLEEL 1
1 GFRTERLPPAVWRGGESEALDRLSKHLDKK 0
0 VWVASVEHTRVNKCSLYASPTGLSPYLRFGCLSCRVLYYNLRELYMK 0
0 LRKRCSPPLSLFGQLLWREFFYTAATNNPNFDRMEGNPI--QIPWDQNPEALAKWAEGRTGFPWIDAIMTQLRQEGWIHHLARHAVACFLTRGDLWISWVSGMK
0 VFEELLLDAGWSVNAGSWMWLSCSAFFQQFFHCYCPVGFGRRTDPSGDYIR 2
2 RYIPILKDFPNRYIYEPWNAPESVQKAANCVVGVDYPKPMVNHAESSRLNIERMKQVYQQLSHYRGL 1
1 ------------------------------- 1
2 ----------------------------------------------- * 0

>CRY2_danRer Danio rerio (zebrafish) BM859709 zcry-dash cryptochrome DASH NM_205686 
0 -----------------------SVHWFRKGLRLHDNPALQEALNGADTVRCVYILDPWFAGSANVGVNRWR 2
1 FLLESLEDLDTSLRKLNSRLFVVRGQPTDVFPRLFK 0
0 EWNVTRLTFEYDSEPYGKERDAAIIKMAQEYGVETVVRNTHTLYNPDR 2
1 IIEMNNHSPPLTFKRFQAIVNRLELPRKPLPTITQEQMARCRTQISDNHDEHYGVPSLEEL 1
1 GFDTEGLSSAVWPGGETEALTRLERHLERK 0
0 AWVANFERPRISGQSLFPSPTGLSPYLRFGCLSCRVFYYNLRDLFMK 0
0 LRRRSSPPLSLFGQLLWREFFYTAGTNNPNFDHMEGNPICVQIPWDHNPEALAKWAEGRTGFPWIDAIMTQLRQEGWIHHLARHAVACFLTRGDLWISWESGMK
0 VFEELLLDADWSVNAGSWMWLSCSAFFQQFFHCYCPVGFGRRTDPSGDYIR 2
2 RYIPKLKDYPNRYIYEPWNAPESVQKAANCIVGVDYPKPMINHAESSRLNIERMKQVYQQLSHYRGL 1
1 SLLASVPTIQEEAEPPMSDDSQASSSSTGQASSPPHLSITAPSTPPL* 0

>CRY2_petMar Petromyzon marinus (lamprey)
0 ------------------------------------------------------------------------ 2
1 FLLQSLEDLDASLHKLNSRLFVIRGQPADVFPRLFK 0
0 EWNISRLTFEYDSEPFGKERDAAIKKLASEAGVEVLVRISHTLYNLDR 2
1 IIELNEGQAPLTYKRFQALVSRMEPPERPVGTITSEVMGPCRTPLWEDHDERYGVPSLEEL 1
1 GFDTDGLTTAVWQGGESEALTRLDRHLERK 0
0 AWVANFERPRMNANSLLASPTGLSPYLRFGCLSCRLFHYKLTELYKK 0
0 VKKNSSPPLSLYGQLLWREFFYTAATNNPKFDRMEGNPICVQIPWDRNPEALAKWAEGRTGYPWIDAIMTQLRQEGWIHHLARHAVACFLTRGDLWVSWEEGMK
0 VFEELLLDADWSVNAGSWMWLSCSSFFQQFFHCYCPVGFGRRTDPNGDYIR 2
2 RYIPLLRAFPAKYIYDPWNAPESVQKTARCIIGVDYPKPMANHAEASRLNIERMKQIYQHLSRYRGL 1
1 ------------------------------- 1
2 ----------------------------------------------- * 0

Insect photolyases and cryptochromes

>CRY1_droMel Drosophila melanogaster (fruit fly) cryptochrome 3TVS CG3772
mATRGANVIWFRHGLRLHDNPALLAALADKDQGIALIPVFIFDGESAGTKNVGYNRMRFLLDSLQDIDDQLQAATDGRGRL
LVFEGEPAYIFRRLHEQVRLHRICIEQDCEPIWNERDESIRSLCRELNIDFVEKVSHTLWDPQLVIETNGGIPPLTYQMF
LHTVQIIGLPPRPTADARLEDATFVELDPEFCRSLKLFEQLPTPEHFNVYGDNMGFLAKINWRGGETQALLLLDERLKVE
QHAFERGFYLPNQALPNIHDSPKSMSAHLRFGCLSVRRFYWSVHDLFKNVQLRACVRGVQMTGGAHITGQLIWREYFYTM
SVNNPNYDRMEGNDICLSIPWAKPNENLLQSWRLGQTGFPLIDGAMRQLLAEGWLHHTLRNTVATFLTRGGLWQSWEHGL
QHFLKYLLDADWSVCAGNWMWVSSSAFERLLDSSLVTCPVALAKRLDPDGTYIKQYVPELMNVPKEFVHEPWRMSAEQQE
QYECLIGVHYPERIIDLSMAVKRNMLAMKSLRNSLITPPPHCRPSNEEEVRQFFWLADvvv

>CRY64_droMel Drosophila melanogaster (fruit fly) 6-4 photolyase 3CVW CG2488-RA (phr6-4) length=540
MDSQRSTLVHWFRKGLRLHDNPALSHIFTAANAAPGKYFVRPIFILDPGILDWMQVGANRWRFLQQTLEDLDNQLRKLNSRLFVVRGKPAEVFPRIFKSWRVEMLTFETDIEPYSVTRDA 
AVQKLAKAEGVRVETHCSHTIYNPELVIAKNLGKAPITYQKFLGIVEQLKVPKVLGVPEKLKNMPTPPKDEVEQKDSAAYDCPTMKQLVKRPEELGPNKFPGGETEALRRMEESLKDEIW 
VARFEKPNTAPNSLEPSTTVLSPYLKFGCLSARLFNQKLKEIIKRQPKHSQPPVSLIGQLMWREFYYTVAAAEPNFDRMLGNVYCMQIPWQEHPDHLEAWTHGRTGYPFIDAIMRQLRQE
GWIHHLARHAVACFLTRGDLWISWEEGQRVFEQLLLDQDWALNAGNWMWLSASAFFHQYFRVYSPVAFGKKTDPQGHYIRKYVPELSKYPAGCIYEPWKASLVDQRAYGCVLGTDYPHRI
VKHEVVHKENIKRMGAAYKVNREVRTGKEEESSFEEKSETSTSGKRKVRRATGSAPKRKR

>CPD_droMel Drosophila melanogaster (fruit fly) thymidine dimer photolyase
MHEDDLKSQLTIARNEINNLRQQVRNLQHVQRKDIETITRLLQDFRCEGCANNNKSAKDKVAGEKQEHQHQQQTQLIESPYRYTVMFTLASYWRESFKIV
LPLQAMKRTKAQKAGPSKKAAKNEKASSEPKSDQESSDEEASTSKALLVSKPDYQNFEQFLTHLEHQRVCTAANIQEFSFRKKRVRVLSKTEDVKESSLG
GVVYWMSRDGRVQDNWALLFAQRLALKLELPLTVVFCLVPKFLNATIRHYKFMMGGLQEVEQQCRALDIPFHLLMGSAVEKLPQFVKSKDIGAVVCDFAP
LRLPRQWVEDVGKALPKSVPLVQVDAHNVVPLWVASDKQEYAARTIRNKINSKLGEYLSEFPPVVRHPHGTGCKNVNTVDWSAAYASLQCDMEVDEVQWA
KPGYKAACQQLYEFCSRRLRHFNDKRNDPTADALSGLSPWLHFGHISAQRCALEVQRFRGQHKASADAFCEEAIVRRELADNFCFYNEHYDSLKGLSSWA
YQTLDAHRKDKRDPCYSLEELEKSLTYDDLWNSAQLQLVREGKMHGFLRMYWAKKILEWTATPEHALEYAILLNDKYSLDGRDPNGYVGCMWSIGGVHDM
GWKERAIFGKVRYMNYQGCRRKFDVNAFVMRYGGKVHKKK