Immunogenomics papers: Difference between revisions

Latest revision as of 01:32, 23 August 2011

Boyd 2010 J of Immunol, Collins lab, Stanford
- sequenced IGH with BIOMED2 primers of 12 people
- describe variation
Boyd et al, Fire lab, Stanford
- sequenced IGH-locus with BIOMED2 primers
Bioinformatics 2011, Collins lab, Stanford
- Benchmark of IGH-identifiers
Tomlinson 1996
- Sanger sequencing of <1000 IGH sequences
- compare germline mutations (=IMGT) versus somatic mutations
- In parts of antibody where there is little germline variation, there is lots of somatic mutations, and the inverse
Glanville 2009, Pons lab, Pfizer
Zemlin 2003
- CDR3 composition is very different between human and mouse

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+* [http://www.jimmunol.org/content/184/12/6986.long Boyd 2010 J of Immunol, Collins lab, Stanford]
+** sequenced IGH with BIOMED2 primers of 12 people
+** describe variation
 * [http://stm.sciencemag.org/content/1/12/12ra23 Boyd et al, Fire lab, Stanford]
 ** sequenced IGH-locus with BIOMED2 primers
+* [http://bioinformatics.oxfordjournals.org/content/26/24/3129.full, Bioinformatics 2011, Collins lab, Stanford]
+** Benchmark of IGH-identifiers
 * [http://www.ncbi.nlm.nih.gov/pubmed/8601832 Tomlinson 1996]
 ** Sanger sequencing of <1000 IGH sequences
 ** compare germline mutations (=IMGT) versus somatic mutations
-** Where there is a little germline variation, they see many somatic mutations and the inverse
+** In parts of antibody where there is little germline variation, there is lots of somatic mutations, and the inverse
 * [http://www.pnas.org/content/106/48/20216 Glanville 2009, Pons lab, Pfizer]
 * [http://www.ncbi.nlm.nih.gov/pubmed/14636599 Zemlin 2003]