Immunogenomics papers
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- Boyd et al, Fire lab, Stanford
- sequenced IGH-locus with BIOMED2 primers
- Tomlinson 1996
- Sanger sequencing of <1000 IGH sequences
- compare germline mutations (=IMGT) versus somatic mutations
- In parts of antibody where there is little germline variation, there is lots of somatic mutations, and the inverse
- Glanville 2009, Pons lab, Pfizer
- Zemlin 2003
- CDR3 composition is very different between human and mouse
