Opsin evolution: Difference between revisions

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This is a set of hand-curated opsins that serves as a gene family classifier ... just blast unknown sequence against the database below and look for the top hits ...
'''See also:''' [[Opsin_evolution:_LWS_PhyloSNPs|LWS]] | [[Opsin_evolution:_Encephalopsin_gene_loss|Encephalopsins]] | [[Opsin_evolution:_Melanopsin_gene_loss|Melanopsins]] | [[Opsin_evolution:_Neuropsin_phyloSNPs|Neuropsin]] | [[Opsin_evolution:_Peropsin_phyloSNPs|Peropsin]] | [[Opsin_evolution:_RGR_phyloSNPs|RGR phyloSNPs]] | [[Opsin_evolution:_update_blog|Update Blog]]


== Introduction to Opsin Evolution ==


>RHO1_homSap rhodopsin ciliary all GT-AG chr3:130,730,172 3q22.1 + 6706 5  12 21 00 00
=== The Curated Set of Metazoan Opsins ===
0 MNGTEGPNFYVPFSNATGVVRSPFEYPQYYLAEPWQFSMLAAYMFLLIVLGFPINFLTLYVTVQHKKLRTPLNYILLNLAVADLFMVLGGFTSTLYTSLHGYFVFGPTGCNLEGFFATLG 1
2 GEIALWSLVVLAIERYVVVCKPMSNFRFGENHAIMGVAFTWVMALACAAPPLAGWSR 2
1 YIPEGLQCSCGIDYYTLKPEVNNESFVIYMFVVHFTIPMIIIFFCYGQLVFTVKE 0
0 AAAQQQESATTQKAEKEVTRMVIIMVIAFLICWVPYASVAFYIFTHQGSNFGPIFMTIPAFFAKSAAIYNPVIYIMMNKQ 0
0 FRNCMLTTICCGKNPLGDDEASATVSKTETSQVAPA* 0


>RHO1_monDom Monodelphis opossum 349
Below is the largest set of phylogenetically dispersed hand-curated opsin sequences ever assembled. The sequences are organized into true orthology classes using coding indels, intron location and phase, synteny of flanking genes, diagnostic residues, blast clustering, and experimental characterization when available. The reference set of opsin sequences includes selected GenBank entries but mostly new opsins extracted from dozens of newly completed genome projects.
0 MNGTEGPNFYVPFSNKTGTVRSPFEEPQYYLADPWQFSCLAAYMFMLIVLGFPINFLTLYVTIQHKKLRTPLNYILLNLAIADLFMVFGGFTMTLYTSLHGYFVFGPTGCNLEGFFATLG 1
2 GEIALWSLVVLAIERYVVVCKPMSNFRFGENHAIIGVAFTWVMALACAFPPLIGWSR 2
1 YIPEGMQCSCGIDYYTLKPEVNNESFVIYMFVVHFTIPLIVIFFCYGQLVFTVKE 0
0 AAAQQQESATTQKAEKEVTRMVIIMVIAFLICWLPYAGVAFYIFTHQGSNFGPIFMTIPAFFAKSSSVYNPVIYIMMNKQ 0
0 FRTCMITTLCCGKNPLGDDEASATASKTETSQVAPA* 0


>RHO1_ornAna rhodopsin rod pigment Ultra20:114,479-118,391
The set serves as a gene family classifier ... just [http://www.proweb.org/proweb/Tools/WU-blast.html uBlast] an unknown candidate opsin against the full database below and look for consistent labeling of the top hits from the <span style="color: #990099;">Opsin Classifier</span>. Then validate the apparent orthology class using three independent classes of rare genomic events (indels, introns, signature residues) by including the new sequence in a full-width [http://bioinfo.genopole-toulouse.prd.fr/multalin/multalin.html multalignment], being sure to include a couple dozen non-opsin GPCRs as controls. Then check for residual bilateral flanking gene adjacency when a genome assembly is available. The whole process takes only 15 seconds per query!
0 MNGTEGQDFYIPMSNKTGVVRSPFEYPQYYLAEPWQYSVLAAYMFMLIMLGFPINFLTLYVTIQHKKLRTPLNYILLNLAFANHFMVLGGFTTTLYTSLHGYFVFGPTGCNIEGFFATLG 1
2 GEIALWSLVVLAIERYIVVCKPMSNFRFGENHAIMGVAFTWIMALACALPPLVGWSR 2
1 YIPEGMQCSCGIDYYTLRPEVNNESFVIYMFVVHFTIPMTIIFFCYGRLVFTVKE 0
0 AAAQQQESATTQKAEKEVTRMVIIMVIAFLICWVPYASVAFYIFTHQGSNFGPIFMTVPAFFAKSSAIYNPVIYIMMNKQ 0
0 FRNCMLTTICCGKNPLGDDEASATASKTEQSSVSTSQVSPA* 0


>RHO1_galGal RH1 RDP1 rhodopsin rod galGal+ ornAna+ homSap+
The set of reference sequences is deliberately not exhaustive -- that seriously over-samples in popular experimental clades such as vertebrates and insects. When a given clade has many similar sequences available, those in species with genome assemblies are chosen to represent the group, for example anole is preferred to gecko, and (rightly or wrongly) any experimental results from gecko transfered over. This avoids the uninformative clutter of near-identical sequences. However if a clade reflects a very deep divergence especially important to opsin evolution (such as lamprey or amphioxus), all available sequences are needed to maximally break up long branches.
0 MNGTEGQDFYVPMSNKTGVVRSPFEYPQYYLAEPWKFSALAAYMFMLILLGFPVNFLTLYVTIQHKKLRTPLNYILLNLVVADLFMVFGGFTTTMYTSMNGYFVFGVTGCYIEGFFATLG 1
2 GEIALWSLVVLAVERYVVVCKPMSNFRFGENHAIMGVAFSWIMAMACAAPPLFGWSR 2
1 YIPEGMQCSCGIDYYTLKPEINNESFVIYMFVVHFMIPLAVIFFCYGNLVCTVKE 0
0 AAAQQQESATTQKAEKEVTRMVIIMVIAFLICWVPYASVAFYIFTNQGSDFGPIFMTIPAFFAKSSAIYNPVIYIVMNKQ 0
0 FRNCMITTLCCGKNPLGDEDTSAGKTETSSVSTSQVSPA* 0


>RHO1_anoCar Anolis lizard
Sequences not available from GenBank were culled from trace archives, tiled contigs, and genome assemblies, typically by uBlastx against the growing set of reference sequences, as described in the [[Opsin_evolution:_annotation_tricks|annotation section]]. The level of error in the curated sequences is very low, declines with time as anomalies are revisited and repaired, but never reaches zero because of problems inherent to experimental data, imperfect sequencing reads, less-than-complete assemblies, and sequence manipulation.
0 MNGTEGQNFYVPMSNKTGVVRNPFEYPQYYLADPWQFSALAAYMFLLILLGFPINFLTLFVTIQHKKLRTPLNYILLNLAVANLFMVLMGFTTTMYTSMNGYFIFGTVGR 2
2 GEMGLWSLVVLAVERYVVICKPMSNFRFGETHALIGVSCTWIMALACAGPPLLGWSR 2
1 YIPEGMQCSCGVDYYTPTPEVHNESFVIYMFLVHFVTPLTIIFFCYGRLVCTVKA 0
0 AAAQQQESATTQKAEREVTRMVVIMVISFLVCWVPYASVAFYIFTHQGSDFGPVFMTIPAFFAKSSAIYNPVIYILMNKQ 0
0 FRNCMIMTLCCGKNPLGDEDTSAGTKTETSTVSTSQVSPA* 0


>RHO1_xenTro frog 354
[http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=17984227,17975064 Rare genomic changes] can supplement (and even displace) traditional maximal likelihood and bayesian inference in resolving polytomic divergence nodes in gene and species tree topologies. Rare genomic changes applicable to opsins include coding indels (deletions and insertions), intron placement (position and phase comparison), synteny (gene order along the chromosome), and gene copy number change (gene gain from retropositional, tandem, segmental, and whole genome duplications; gene loss from pseudogenization or deletion). Results from these methods must be evaluated for their susceptibility to homoplasy (misleading recurrent independent events that mimic a single event) and incomplete penetration in the population level at the time of speciation (lineage sorting).
0 MNGTEGPNFYIPMSNKTGVVRSPFDYPQYYLAEPWKYSALAAYMFLLILLGFPINFMTLYVTIQHKKLRTPLNYILLNLVFANHFMVLCGFTVTMYTSMHGYFIFGQTGCYIEGFFATLG 1
2 GEMALWSLVVLAIERYVVVCKPMANFRFGENHAIMGVVFTWIMALSCAAPPLFGWSR 2
1 YIPEGMQCSCGVDYYTLKPEVNNESFVVYMFIVHFTIPLCVIFFCYGRLLCTVKE 0
0 AAAQQQESATTQKAEKEVTRMVVMMVIFFLICWVPYAYVAFYIFTHQGSDFGPVFMTVPAFFAKSSAIYNPVIYIVLNKQ 0
0 FRNCLITTLCCGKNPFGDEEGSSAASSKTEASSVSSSQVSPA* 0


>RHO1_Protopterus lungfish partial
Opsins are more informatively stored as proteins since nucleotide sequences are far too diverged at metazoan evolutionary distances and do not explicitly manifest residue properties that experience selection. These protein sequences are parsed into constituent exons using genomic information when available -- fortunately splicing mechanisms are exceeding well conserved across animal phyla. When not directly available (eg the opsin originated as a cDNA in a species lacking a genome project), exon breaks have been inferred from the phylogenetically closest neighbors via heterologous alignment (but not in insects where intron turnover is too high). As an example, lamprey opsins from Geotria australis and Lethenteron japonicum can work as blastn queries to locate orthologs within the Petromyzon maritimus genome project (which consists solely of 19 million traces as of mid-December 2007).Numbers flanking exons, namely 0 1 2, show the [[Opsin_evolution:_annotation_tricks|phasing]] of each intron, eg 12 means an overhang of 1 bp at the 3' end of an exon with fragmentary codon completed by a 2 bp overhang at the beginning of the next exon.
0                               LAEPWKYSALAAYMFFLILVGFPINFMTLYVTIQHKKLRTPLNYILLNLAIGGLFMVFGGFTTTMYTSMNGYFVFGVTGCNIEGFFATFG 1
2 GILGLWSLVVLAIERYIVVCKPMSNFRFGENHAIMGIVFTWIMTLACAAPPLFGWSR 2
1 YIPEGMQCSCGIDYYTLKPEVNNESFVIYMFVVHFLIPLIIIFFCYGRLVCTVKE 0
0 AAAQQQESATTQKAEKEVTRMVYIMVISFLVCWLPYAFVAFYIFTHKGSDFGPVFMTAPAFFAKTAAFYNPVIYIFMNKQ 0
0 FRNCM                                    *0


>RHO1_danRer Danio zebrafish
Intron position and phasing are conserved over vast evolutionary distances -- human to sponge and beyond -- with the exception of certain rogue lineages (that unfortunately includes two major model organisms). Informative conservation is still available long after protein percent identity has slid into the twilight zone of uncertainty (critical in opsins because they are readily confused with generic GPCR receptors). For example, no variation whatsoever in intron pattern has occurred in any vertebrate opsin class since lamprey divergence, no events in many billions of years of branch length. Prior to that, rare events are observed, for example LWS opsins gained an extra intron of phase 12. In a protein having 333 locations with 3 possible phases at each location, convergent evolution (homoplasy) is uncommon, that is, [[Opsin_evolution:_ancestral_introns|close examination]] establishes opsin introns are still highly informative even when sequences have greatly diverged.
0 MNGTEGPAFYVPMSNATGVVRSPYEYPQYYLVAPWAYGFVAAYMFFLIITCNIEGFFATLG 1
2 GEMGLWSLVVLAVERYVVICKPMSNFRFGETHALIGVSCTWIMALACAGPPLLGWSGFPVNFLTLYVTIEHKKLRTPLNYILLNLAIADLFMVFGGFTTTMYTSLHGYFVFGRLGCNLEGFFATLG 1
2 GEMGLKSLVVLAIERWMVVCKPVSNFRFGENHAIMGVAFTWVMACSCAVPPLVGWSR 2
1 YIPEGMQCSCGVDYYTRTPGVNNESFVIYMFIVHFFIPLIVIFFCYGRLVCTVKE 0
0 AARQQQESETTQRAEREVTRMVIIMVIAFLICWLPYAGVAWYIFTHQGSEFGPVFMTLPAFFAKTSAVYNPCIYICMNKQ 0
0 FRHCMITTLCCGKNPFEEEEGASTTASKTEASSVSSSSVSPA* 0


>RHO1_Raja erinacea rod opsin intronated using RHO1_Callorhinchus fragment
Insertions and deletions ([[Opsin_evolution:_informative_indels|coding indels]]) are sufficiently uncommon in opsins that they are a potentially phylogenetically informative class of rare genomic events. We'll harvest these from a [[Opsin_evolution:_alignment|massive opsin alignment]] and stratify by location and phylogenetic depth. Indels are more subject to homoplasy than intron gain or loss but the risk of that varies greatly by region. Indels are less affected by lineage-specific rates than other event classes.
0 MNGTEGENFYVPMSNKTGVVRSPFDYPQYYLGEPWMFSALAAYMFFLILTGLPVNFLTLFVTIQHKKLRQPLNYILLNLAVSDLFMVFGGFTTTIITSMNGYFIFGPAGCNFEGFFATLG 1
2 GEVGLWCLVVLAIERYMVVCKPMANFRFGSQHAIIGVVFTWIMALSCAGPPLVGWSR 2
1 YIPEGLQCSCGVDYYTMKPEVNNESFVIYMFVVHFTIPLIVIFFCYGRLVCTVKE 0
0 AAAQQQESESTQRAEREVTRMVIIMVVAFLICWVPYASVAFYIFINQGCDFTPFFMTVPAFFAKSSAVYNPLIYILMNKQ 0
0 FRNCMITTICLGKNPFEEEESTSASASKTEASSVSSSQVAPA* 0


>RHO1_lamprey1 petMar Petromyzon marinus
Syntentic relationships can have great value in determining orthology relationships, though gene order is not often conserved over great evolutionary timescales due to chromosomal rearrangements. As with introns, certain rogue lineages lose almost all this information. Tracking synteny is nomenclaturally confused because many genes are unnamed and simply numbered by annotation pipeline procedures in each genome without homological consistency. Here, HUGO-convention names are used for two genes flanking each side of a given human opsin. Strand orientation is noted relative to a fixed convention of plus strand for the human opsin. Then each genome assembly is visited to determine the extent of conservation of these flanking genes and orientation. In the event humans lack the gene, synteny is defined by the nearest diverging species, typically platypus or chicken, that has the gene. Sometimes the original synteny is only partly retained (left or right half-synteny). For deeply diverging species such as amphioxus, flanking genes can be are pushed forward into 'nearby' species. This can also be done without an assembly in species with sufficiently large contigs containing the opsin. Blast clustering can be uncertain because of diminishing percent identity or even loss of these flanking genes; common chromosomal displacements such as inversions eventually disrupt most syntentic arrangements.
0 MNGTEGENFYIPFSNKTGLARSPFEYPQYYLAEPWKYSVLAAYMFFLILVGFPVNFLTLFVTVQHKKLRTPLNYILLNLAVANLFMVLFGFTLTMYSSMNGYFVFGPTMCNFEGFFATLG 1
2 GEMSLWSLVVLAIERYIVICKPMGNFRFGSTHAYMGVAFTWFMALSCAAPPLVGWSR 2
1 YLPEGMQCSCGPDYYTLNPNFNNESFVIYMFLVHFIIPFIVIFFCYGRLLCTVKE 0
0 AAAAQQESASTQKAEKEVTRMVVLMVIGFLVCWVPYASVAFYIFTHQGSDFGATFMTVPAFFAKTSALYNPIIYILMNKQ 0
0 FRNCMITTLCCGKNPLGDEDSGASTSKTEVSSVSTSQVSPA* 0


>RHO1_lamprey2 Geotria australis rodRhA
The fasta header of each sequence serves as a miniature database that conveniently collects this and other basic information, with fields showing the opsin type, genus, species and common name, accession number, best PubMed citation, indels, intron pattern, sequence length, lambda max adsorption, flanking synteny, and G protein type with which it interacts (all subject to availability and work-in-progress). These fasta headers by themselves provide a quick over view the opsin reference set collection -- simply paste into a blank document and pull lines containing '>'.
0 MNGTEGQNFYIPFSNKTDVARSPFEYPQYYLAEPWKFSALAAYMFFLILVGFPVNFLTLFVTVQHKKLRTPLNYILLNLAVSNLFMILFGFTTTMYTSMNGYFVFGPTMCSIEGFFATLG 1
2 GEVSLWSLVVLAIERYIVICKPMGNFRFGNTHAIMGVALTWVMALSCAAPPLLGWSR 2
1 YLPEGMQCSCGPDYYTMNPTYNNESFVIYMFIVHFTIPFVIIFFSYGRLLCTVKE 0
0 AAAAQQESASTQKAEKEVTRMVVLMVVGFLVCWVPYASVAFYIFTNQGSDFGATFMTLPAFFAKSSALYNPVIYILMNKQ 0
0 FRNCMITTLCCGKNPLGDDDSGASTSKTEVSSVSTSQVAPA* 0


>RHO1_lamprey3 Lethenteron japonicum
Thus the usual querying at GenBank does not remotely compare to the <span style="color: #990099;">Opsin Classifier</span>. Those sequences -- often mis-annotated by an unattended pipeline or well-intentioned individual with no qualifications in comparative genomics -- are spread out over separate databases not accessible by any single method, with difficult-to-interpret edge creep of genomic blast matches, uncorrected frameshifts, missing stop codons and erroneous amino terminals.
0 MNGTEGDNFYVPFSNKTGLARSPYEYPQYYLAEPWKYSALAAYMFFLILVGFPVNFLTLFVTVQHKKLRTPLNYILLNLAMANLFMVLFGFTVTMYTSMNGYFVFGPTMCSIEGFFATLG 1
2 GEVALWSLVVLAIERYIVICKPMGNFRFGNTHAIMGVAFTWIMALACAAPPLVGWSR 2
1 YIPEGMQCSCGPDYYTLNPNFNNESYVVYMFVVHFLVPFVIIFFCYGRLLCTVKE 0
0 AAAAQQESASTQKAEKEVTRMVVLMVIGFLVCWVPYASVAFYIFTHQGSDFGATFMTLPAFFAKSSALYNPVIYILMNKQ 0
0 FRNCMITTLCCGKNPLGDDESGASTSKTEVSSVSTSQVSPA* 0


>RHO2_galGal rhodopsin-like cone galGal+ ornAna- homSap-
As worst-case scenario, half-baked annotation of the sea urchin genome by pipelines and casual procedures has left a awful legacy of bogus opsin gene structures at GenBank, journal alignments, and genome browsers -- often mis-classified because of an inadequate set of reference sequences and non-opsin GPCR controls, chimeric confusion in tandem duplicates, and non-consideration of intron structure, indels, and synteny. These errors may ripple downstream to errors by subsequent scientists trusting GenBank nr as classifier and lead to a whole subculture taken up with non-existent "virtual" opsins and attendant vacuous speculation on echinoderm photoreception.
0 MNGTEGINFYVPMSNKTGVVRSPFEYPQYYLAEPWKYRLVCCYIFFLISTGLPINLLTLLVTFKHKKLRQPLNYILVNLAVADLFMACFGFTVTFYTAWNGYFVFGPVGCAVEGFFATLG 1
2 GQVALWSLVVLAIERYIVVCKPMGNFRFSATHAMMGIAFTWVMAFSCAAPPLFGWSR 2
1 YMPEGMQCSCGPDYYTHNPDYHNESYVLYMFVIHFIIPVVVIFFSYGRLICKVRE 0
0 AAAQQQESATTQKAEKEVTRMVILMVLGFMLAWTPYAVVAFWIFTNKGADFTATLMAVPAFFSKSSSLYNPIIYVLMNKQ 0
0 FRNCMITTICCGKNPFGDEDVSSTVSQSKTEVSSVSSSQVSPA* 0


>RHO2_anoCar rhodopsin-like cone anoCar+ HMGA1 GRM4 RHO2 MLN LEMD2 IHPK3
Melanopsins, the unexpected rhabdomeric-class Gq-coupled opsin recently found in upper deuterostomes, illustrate some of the difficulties of accurate annotation. They can be confused homologically due to various expansions and contractions. Mammals, human through platypus, have a single melanopsin. However a common ancestor to chicken, lizard, frog, teleost fish, and possibly cartilaginous fish had a multi-gene segmental duplication with both resulting melanopsins retained (though substantially diverged). In ray-finned fish, a processed retrogene arose that may be functional in zebrafish though lost in fugu and stickleback. After whole genome duplication, zebrafish also retained two copies of the original melanopsin. Chondrichthyes also have a second copy of the primary melanopsin but synteny -- which is essential for analysis since intron placement is uninformative in duplications and sequence alignment too dependent on unknown rates -- is not available in the current contig-level assembly.
0 MNGTEGINFYVPLSNKTGLVRSPFEYPQYYLAEPWKYKVVCCYIFFLIFTGLPINILTLLVTFKHKKLRQPLNYILVNLAVADLFMACFGFTVTFYTAWNGYFIFGPIGCAIEGFFATLG 1
2 GQVALWSLVVLAIERYIVVCKPMGNFRFSATHALMGISFTWFMSFSCAAPPLLGWSR 2
1 YIPEGMQCSCGPDYYTLNPDYHNESYVLYMFGVHFVIPVVVIFFSYGRLICKVRE 0
0 AAAQQQESASTQKAEREVTRMVILMVLGFLLAWTPYAMVAFWIFTNKGVDFSATLMSVPAFFSKSSSLYNPIIYVLMNKQ 0
0 FRNCMITTICCGKNPFGDEDVSSSVSQSKTEVSSVSSSQVSPA* 0


>RHO2_Gekko gekko 467 Cone visual pigments are present in gecko rod cells
Amphioxus contains two melanopsins from an apparently independent duplication. Flanking gene order today bears no relation to any vertebrate gene order. The lamprey situation awaits assembly of its traces or targeted transcript studies. At this time, only a four-exon fragmentary melanopsin can be recovered (however with high percent identity, 80%). Possibly orthologs of this melanopsin locus could be tracked into the highly derived tunicates, acorn worm, and sea urchins. The distinctive intron pattern may even allow melanopsin antecedents to be identified in Cnidaria and Protostomia. At this point, the best blastp match to insects stands at 37% with no evident syntenic or intronic support.
0 MNGTEGINFYVPLSNKTGLVRSPFEYPQYYLADPWKFKVLSFYMFFLIAAGMPLNGLTLFVTFQHKKLRQPLNYILVNLAAANLVTVCCGFTVTFYASWYAYFVFGPIGCAIEGFFATIG 1
2 GQVALWSLVVLAIERYIVICKPMGNFRFSATHAIMGIAFTWFMALACAGPPLFGWSR 2
1 FIPEGMQCSCGPDYYTLNPDFHNESYVIYMFIVHFTVPMVVIFFSYGRLVCKVRE 0
0 AAAQQQESATTQKAEKEVTRMVILMVLGFLLAWTPYAATAIWIFTNRGAAFSVTFMTIPAFFSKSSSIYNPIIYVLLNKQ 0
0 FRNCMVTTICCGKNPFGDEDVSSSVSQSKTEVSSVSSSQVAPA* 0


>RHO2_Latimeria chalumnae (coelacanth) RH2 opsin
While clade-specific proliferations of melanopsins -- and implied role subfunctionalizations -- confounds the situation for chordates, it has little impact on the opsin classifier described here. Unknown sequences readily find their place because of the extensive phylogenetic representation of reference sequence orthology classes and the inherent distance of melanopsins from the ciliary sub-collection. At that level of alignment, the melanopsins serve as outgroup to ciliary opsins and so help define motifs specific to Gt-coupled signaling and other structure/function issues.
0 MNGTEGMNFYVPLSNRTGLVRSPFEYTQYYLAEPWKFSVLCAYMFLLIILGFPINFLTLLVTFKHKKLRQPLNYILVNLAVASLFMVVFGFTVTFYSSLNGYFVLGPMGCAMEGFFATLG 1
2 GQVALWSLVVLAIERYIVVCKPMGNFRFASSHAIMGIAFTWIMALACAAPPLVGWSR 2
1 YIPEGLQCSCGPDYYTLNPDFHNESYVMYLFLVHFLLPIIIIFFTYGRLICKVKE 0
0 AAAQQQESASTQKAEKEVTRMVILMVIGFLTAWVPYASAAFWIFCNRGAEFTATLMTVPAFFSKSSCLFNPIIYVLLNKQ 0
0 FRNCMITTLCCGKNPLGDDDTSSAVSQSKTDVSSVSSSQVSPA* 0


>RHO2_Geotria australis lamprey rod RhB  lamprey
It appears however that far too much 'lumping' has taken place in nearly all non-imaging opsins, for example encephalopsins, melanopsins, and peropsins. The taxonomic counterpart  is too much lumping of species outside of mammal. In all likelihood, additional opsin orthology classes need definition and distinctive naming. These opsins were belatedly discovered through whole-genome homology searches; they may differ one from another just as much as cone and rod opsins. However, it is currently difficult to disentangle phylogenetically short-lived expansions within known families from deep-rooted parallel-evolving subfamilies concentrated (superficially) within 'secondary' photoreception systems. Genome sampling density and completion efforts are overwhelmingly concentrated in a few model species and near human.
0 MNGTEGANFYIPFHNRTGVVRSPYEYPQYYLADPWMYSAISAYVFTLILIGFPVNFMTLFVTFKLKKLRQPLNFILVNLCVADLLMIMFGFTTTFYTAMNGYFVFGPTGCNIEGFFATLG 1
2 GEVSLWSLVMLAIERYIVVCKPMGNFRFATTHAALGVVFTWVMASACAVPPLVGWSR 2
1 YIPEGMQCSCGPDYYTLNPKYYNESYVIYLFLVHFLLPVTIIFFTYGRLICTVKE 0
0 AAAQQQESASTQKAEREVTRMVIIMVVGFLVCWVPYASFAFYLFMNKGILFSATAMTVPAFFSKSSVLYNPIIYVLLNKQ 0
0 FRTCMVTTLFCGKNPFGEDDSSMVSTSKTEVSSVSSSQVSPS* 0


>SWS1_homSap  5 exons all GT-AG Blue opsin chr7:128,199,783-128,203,087 7q32.1 - 3305 5 348 (tritanopia) [MIM:190900].
We should not be too hasty to write off peropsins as mere auxiliary retinal isomerases that replenish cis-retinal for 'real' opsins. This reaction is not a simple isomerization (like glucose isomerase) but photoisomerization with an evolutionarily tuned and conserved visual light action spectrum. There is no reason that trans-retinal cannot be the signaling agonist with conversion to all-cis retinal the waste product. Pairing two opposing types of opsins in a single cell or nearby cells then completes a full visual cycle with interesting opportunities for sensory capabilities. Of all the so-called retinal isomerases, peropsins retain more of the diagnostic residues of ciliary opsins; possibly they function similarly but in balance with another opsin class co-expressed in the same cell. Melanopsin, surprisingly, is fully capable of self-replenishment, so perhaps the first-studied ciliary opsins are the true anomaly with their need for an auxiliary replenishment cycle in the retinal epithelium.
0 MRKMSEEEFYLFKNISSVGPWDGPQYHIAPVWAFYLQAAFMGTVFLIGFPLNAMVLVATLRYKKLRQPLNYILVNVSFGGFLLCIFSVFPVFVASCNGYFVFGRHVCALEGFLGTVA 1
2 GLVTGWSLAFLAFERYIVICKPFGNFRFSSKHALTVVLATWTIGIGVSIPPFFGWSR 2
1 FIPEGLQCSCGPDWYTVGTKYRSESYTWFLFIFCFIVPLSLICFSYTQLLRALKA 0
0 VAAQQQESATTQKAEREVSRMVVVMVGSFCVCYVPYAAFAMYMVNNRNHGLDLRLVTIPSFFSKSACIYNPIIYCFMNKQ 0
0 FQACIMKMVCGKAMTDESDTCSSQKTEVSTVSSTQVGPN* 0


>SWS1_macDom Monodelphis
It's abundantly clear from distinct ancestral introns and alignment clustering that peropsins together with neuropsins and RGR opsins comprise a distinctive subclade within the overall opsin gene tree. The comparative genomics of RGR illustrates the danger of phylogenetic under-sampling: with much deeper sampling, we can observe that the E/DRY motif -- conserved across all classes of opsins (indeed GPCR) and critical to maintaining non-signaling conformation -- has become GRY in all boreoeutheran mammals (it's ERY in afrotheres, lost without residual debris in marsupials, and DRY from platypus through shark and even tunicate, and DRY in neuropsins and peropsins).
0 MSGDEEFYLFKNISSVGPWDGPQYHIAPAWAFHFQTVFMGFVFCAGTPLNAVVLVATLRYKKLRQPLNYILVNVSLCGFIFCIFAVFTVFISSSQGYFIFGRHVCAMEAFLGSVA 1
2 GLVTGWSLAFLAFERFIVICKPFGNFRFNSKHAMMVVLATWVIGIGVSIPPFFGWSR 2
1 FIPEGLQCSCGPDWYTVGTKYRSEYYTWFLFIFCFIMPLFLICFSYSQLLRALRA 0
0 VAAQQQESATTQKAEREVSRMVVMMVGSFCLCYVPYAALAMYMVNNQNHGLDLRLVTIPAFFSKSACVYNPIIYCFMNKQ 0
0 FHACIMEMVCRKPMTDDSDVSSSQKTEVSAVSSSQVGPT* 0


>SWS1_galGal violet cone pigment
In other words, after several trillion years of branch length conservation as charged amino acid, a radical amino acid substitution has taken hold -- to glycine with its tiny non-interactive side chain. Yet this subclade of placental mammals, this glycine has been conserved without exception for over two billion years of branch length. Given the importance of this motif for maintaining the non-signaling state, this suggests a major change in functional properties of RGR opsins within boreoeutheres, a change that does not tolerate a reduced alphabet at this site. That change might be breakdown to non-signaling isomerase within that clade. It remains unclear how marsupials cope without the gene at all or how Afrothera and Xenarthra visual cycles differ from other placental mammals.
0 MSSDDDFYLFTNGSVPGPWDGPQYHIAPPWAFYLQTAFMGIVFAVGTPLNAVVLWVTVRYKRLRQPLNYILVNISASGFVSCVLSVFVVFVASARGYFVFGKRVCELEAFVGTHG 1
2 GLVTGWSLAFLAFERYIVICKPFGNFRFSSRHALLVVVATWLIGVGVGLPPFFGWSR 2
1 YMPEGLQCSCGPDWYTVGTKYRSEYYTWFLFIFCFIVPLSLIIFSYSQLLSALRA 0
0 VAAQQQESATTQKAEREVSRMVVVMVGSFCLCYVPYAALAMYMVNNRDHGLDLRLVTIPAFFSKSACVYNPIIYCFMNKQ 0
0 FRACIMETVCGKPLTDDSDASTSAQRTEVSSVSSSQVGPT* 0


>SWS1_Taeniopygia guttata
Comparative Genomics of DRY motifs in exon 3 of RGR Opsins:
0 MDEEEFYLFKNQSSVGPWDGPQYHIAPMWAFYLQTIFMGLVFVAGTPLNAIVLIVTIKYKKLRQPLNYILVNISVSGLMCCVFCIFTVFIASSQGYFVFGKHMCAFEGFAGATG 1
1 RWPYGSDGCQAHGFQGFVTALASICSSAAIAW<font  color="magenta">G</font>RYHHYCT 1 human
2 GLVTGWSLAFLAFERYIVICKPFGNFRFNSRHALLVVAATWIIGVGVAIPPFFGWSR 2
1 RWPYGSDGCQAHGFQGFVTALASICSSAAIAW<font  color="magenta">G</font>RYHHYCT 1 macaque
1 YIPEGLQCSCGPDWYTVGTKYKSEYYTWFLFIFCFIVPLSLIIFSYSQLLSALRA 0
1 RWPYGSGGCQAHGFQGFTTALASICGSAAIAW<font  color="magenta">G</font>RYHHYCT 1 lemur
0 VAAQQQESATTQKAEREVSRMVVVMVGSFCMCYVPYAALAMYMVNNREHGIDLRLVTIPAFFSKSSCVYNPIIYCFMNKQ 0
1 RWPYGSDGCKVHGFQGFATALASISGSAAIAW<font  color="magenta">G</font>RYHQYCT 1 treeshrew
0 FRACIMETVCGRPMTDDSEVSSSAQRTEVSSVSSSQVGPS* 0
1 RWPHGSEGCQVHGFQGFATALASICGSAAVAW<font  color="magenta">G</font>RYHHYCT 1 mouse
1 RWPYGSDGCQAHGFQGFATALASICGSAAIAW<font  color="magenta">G</font>RYHHYCT 1 rabbit
1 RWPYGSDGCQAHGFQGFATALASICGSAAIAW<font  color="magenta">G</font>RYHHYCT 1 pika
1 RWPYGSEGCQAHGFQGFVTALASICSSAAVAW<font  color="magenta">G</font>RYHHFCT 1 cow
1 RWPYGSDGCQAHGFQGFVTALASICSSAAIAW<font  color="magenta">G</font>RYHHYCT 1 horse
1 RWPYGSNGCQAHGFQGFVTALASICSSAAIAW<font  color="magenta">G</font>RYHHYCS 1 cat
1 RWPYGPDGCQAHGFQGFATALASICSSAALAW<font  color="magenta">G</font>RYHHYCT 1 dog
1 RWPYGSGGCQAHGFQGFAAALASICGSAAVAW<font  color="magenta">G</font>RYHHYCT 1 bat
1 RWPFGPDGCQAHGFQGFATALASICSSAAIAW<font  color="magenta">G</font>RYHHYCT 1 shrew
1 RWPYGSDGCQAHGFQGFVTALASICSCAAIAW<font  color="blue">E</font>RYHHYCT 1 elephant
1 RWPYGSDGCQAHGFQGFVMALTSICSCAAIAW<font  color="blue">E</font>RYHHYCT 1 hyrax
1 HWPYGSGGCQAHGFQGFTVALASICSCAAIAW<font  color="blue">E</font>RYHHYCT 1 tenrec
1 RWPHGSDSCQAHSFQGFATALASISSSAAIAW<font  color="blue">E</font>RYRHHCT 1 sloth
1 RWPYGSGGCQAHGFQGFVTALASISSSAAIAW<font  color="blue">E</font>RCHRHCI 1 armadillo
1 HWPYGAEGCRLHGFQGFATALASISLSAAIGW<font  color="#00CC66">D</font>RYLRHCS 1 platypus
1 YWPYGSDGCQIHGFHGFLTALTSISSAAAVAW<font  color="#00CC66">D</font>RHHQYCT 1 lizard
1 YWPYGSEGCQIHGFQGFLTALASISSSAAVAW<font  color="#00CC66">D</font>RYHHYCT 1 chicken
1 YWPYGSEGCQIHGFQGFVAALSSIGSCAAIAW<font  color="#00CC66">D</font>RYHQYCT 1 frog
1 YWPYGSDGCQTHGFQGFVTALASIHFIAAIAW<font  color="#00CC66">D</font>RYHQYCT 1 stickleback
1 YWPYGSDGCQTHGFQGFMTALASIHFIAAIAW<font  color="#00CC66">D</font>RYHQYCT 1 zfish1
1 HWPFGSEGCQLHAFQGMVSILAAISFLGAVAW<font  color="#00CC66">D</font>RYHQYCT 1 zfish2
1 YWPYGSEGCQTHGFQGFVTALASIHFVAAIAW<font  color="#00CC66">D</font>RYHQYCT 1 tetraodon
1 YWPYGSDGCQTHGFQGFVTALASIHFVAAIAW<font  color="#00CC66">D</font>RYHQYCT 1 fugu
1 YWPYGSEGCQTHGFHGFLTALASIHFIAAIAW<font  color="#00CC66">D</font>RYHQYCT 1 medaka
1 YWPYGSDGCQTHGFQGFMTALASIHFIAAIAW<font  color="#00CC66">D</font>RYHQYCT 1 pimephales
1 YWPYGSDGCQTHGFQGFMTALASIHFVAAIAW<font  color="#00CC66">D</font>RYHQYCT 1 osmerus
1 YWPYGSEGCQTHGFHGFLMALASINACAAIAW<font  color="#00CC66">D</font>RYHQNCS 1 elephantshark
1 EWPFGSIGCQLDAFIGMAPTFISIAGAALVAK<font  color="#00CC66">D</font>KYYRICK 1 tunicate 1
1 RWLFGKFGCYFHGFAGMLFGLGSIGNLTVISI<font  color="#00CC66">D</font>RYIITCK 1 tunicate 2
1 QWPFGDLGCQVDAFIGMAPTFISIAGAALIAK<font  color="#00CC66">D</font>KYYRFCK 1 tunicate 2


>SWS1_Gekko gecko
Excellent recent publications have greatly added to our understanding of the evolutionary origin of light reception capabilities, yet only with the advent of genomic sequencing have we begun to get a full grip on opsins and a few other evo-devo photoreceptor components such as PAX6. Yet critical early-diverging metazoan genomes that might retain information on ancestral characters are greatly under-represented given the branch lengths involved. No purpose is served by elaborate gene tree computations that include a single token peropsin or parietopsin among hundreds of cone opsins; if opsins are central to the endeavor yet so haphazardly annotated, what is the status of dozens of lesser but still critical photoreceptor gene families?
0 MSGEEDFYLYANISSVGPFDGPQYHIAPMWAFYFQTAFMGFVFFVGTPLNAIILFAIVKYKKLRQPLNYILVNISAAGFLFCVVAVFTVFISSSQGYFIFGKHICALEAFLGSLA 1
2 GLVTGWSLAFLALERYIVICKPFGNFRFSAKHASLVVAATWFIGIGVSIPPYFGWSR 2
1 FIPEGLQCSCGPDWYTVGTKYYSEYYTWFLFVLCFIVPLSIIVFSYSQLLSALRA 0
0 VAAQQQESATTQKAEREVSRMVVVMVGSFCLCYVPYAALAMYMVNNRNHGIDLRMVTIPAFFSKSSCVYNPIIYCFMNKQ 0
0 FRGCILEMVCGKTMAEESEVSSASQKTEVSSVSSSQVGPS* 0


>SWS1_Uta stansburiana
The question of how many times eyes independently arose is ill-posed. We can only wonder how people with no grasp whatsoever of the underlying molecular biology of photoreception could pontificate so boldly on its evolution prior to even sequencing of the first opsin in 1980. First collect comprehensive comparative genomic data sets on all the components in all the relevant clades; then ask what it could mean to homologenize two contemporary systems comprised of partially overlapping sets of heterogeneous paralogs from assorted ancient gene families having long complex histories of clade-specific expansion and contraction cycles. If four arrestins serve a thousand GPCR, if even specialized photoreceptor cells express dozens of barely related 7TM signaling molecules, it's difficult to imagine what a cognate arrestin or ectopic evo-devo cassette might be. It's difficult enough to reconstruct an ancestral gene or two; reconstructing ancestral systems biology interactions lies in the future.
0 MSGEEDFYLFENISSVGPWDGPQYHIAPMWAFYFQTAFMGFVFFAGTPLNAIILIVTVKYKKLRQPLNYILVNISFAGFLFCVFSVFTVFLASSQGYFFFGRHICALEAFLGSVA 1
2 GLVTGWSLAFLAFERYIVICKPFGNFRFNSKHALLVVAATWFIGIGVSIPPFFGWSR 2
1 FIPEGLQCSCGPDWYTVGTKYKSEYYTWFLFIFCFIVPLTLIIFSYSQLLGALRA 0
0 VAAQQQESATTQKAEREVSRMVVVMVGSFCLCYVPYAALAMYMVNNRDHGIDLRLVTIPAFFSKSACVYNPIIYCFMNKQ 0
0 FRACIMETVCGKPMTDESDVSSSAQKTEVSSVSSSQVSPS* 0


>SWS1_Xenopus laevis
After reviewing topics such as ciliary opsin in protostomes, rhabdomeric opsins in deuterostomes,the rich opsin repertoires in cnidarians and probable opsins in sponges, we will consider special topics such as the origin of image-forming eyes between amphioxus and lamprey divergences, noting throughout that our notion of 'eye' is much more nuanced than earlier. The reconstruction of Ur-bilateran and Urmetazoan eyes awaits additional cnidarian genomes but no new ones are currently underway. However the plethora of new arthropod and lophotrochozoan genome assemblies has opened up new avenues of research as the realization grows that fly and nematode model species are exceedingly derived, with better ancestral characters retained in other lineages.
0 MLEEEDFYLFKNVSNVSPFDGPQYHIAPKWAFTLQAIFMGMVFLIGTPLNFIVLLVTIKYKKLRQPLNYILVNITVGGFLMCIFSIFPVFVSSSQGYFFFGRIACSIDAFVGTLT 1
2 GLVTGWSLAFLAFERYIVICKPMGNFNFSSSHALAVVICTWIIGIVVSVPPFLGWSR 2
1 YMPEGLQCSCGPDWYTVGTKYRSEYYTWFIFIFCFVIPLSLICFSYGRLLGALRA 0
0 VAAQQQESASTQKAEREVSRMVIFMVGSFCLCYVPYAAMAMYMVTNRNHGLDLRLVTIPAFFSKSSCVYNPIIYSFMNKQ 0
0 FRGCIMETVCGRPMSDDSSVSSTSQRTEVSTVSSSQVSPA* 0


>SWS1_Danio rerio
Numerous conflicting gene trees have been published for ciliary opsins. Some methodologies have bordered on the preposterous -- thin phylogenetic coverage, dimly related outgroups such as adrenergic receptors, and naive underlying mutational models assumed for maximal likelihood despite great diversity of species and many billions of years of branch length. Nonetheless the resultant trees have only moderate conflict, suggesting that a definitive opsin gene tree is not far off. We'll do this using the multiple types of evidence discussed above.
0 MDAWAVQFGNASKVSPFEGEQYHIAPKWAFYLQAAFMGFVFIVGTPMNGIVLFVTMKYKKLRQPLNYILVNISLAGFIFDTFSVSQVSVCAARGYYSLGYTLCSMEAAMGSIA 1
2 GLVTGWSLAVLAFERYVVICKPFGSFKFGQGQAVGAVVFTWIIGTACATPPFFGWSR 2
1 YIPEGLGTACGPDWYTKSEEYNSESYTYFLLITCFMMPMTIIIFSYSQLLGALRA 0
0 VAAQQAESESTQKAEREVSRMVVVMVGSFVLCYAPYAVTAMYFANSDEPNKDYRLVAIPAFFSKSSSVYNPLIYAFMNKQ 0
0 FNACIMETVFGKKIDESSEVSSKTETSSVSA* 0


>SWS1_Oryzias latipes
The first point to be understood in deuterostome ciliary opsin evolution is jawless fish such as lamprey already exhibit a full-blown set of modern rod and cone opsins whereas earlier diverging clades as represented by hemichordate, echinoderm, amphioxus and tunicate genomes totally lack them and indeed lack imaging eyes altogether, while using their rhabdomeric opsins in a very distinct signaling system for their own photoreception systems. Despite 7 sequenced opsin mRNAs in the amphioxus Branchiostoma belcheri and an initial assembly in Branchiostoma floridae providing counterparts there, no rod/cone opsin can be located there or in earlier diverging deuterostomes with genome projects (3 tunicates, 2 urchins, 1 acorn worm). These species may have larval eye spots, ocelli, pigment cells, and related photoreceptors but lack imaging eyes.
0 MGKYFYLYENISKVGPYDGPQYYLAPTWAFYLQAAFMGFVFFVGTPLNFVVLLATAKYKKLRVPLNYILVNITFAGFIFVTFSVSQVFLASVRGYYFFGQTLCALEAAVGAVA 1
2 GLVTSWSLAVLSFERYLVICKPFGAFKFGSNHALAAVIFTWFMGVGCACPPFFGWSR 2
1 YIPEGLGCSCGPDWYTNCEEFSCASYSKFLLVTCFICPITIIIFSYSQLLGALRA 0
0 VAAQQAESASTQKAEKEVSRMIIVMVASFVTCYGPYALTAQYYAYSQDENKDYRLVTIPAFFSKSSCVYNPLIYAFMNKQ 0
0 FNGCIMEMVFGKKMEEASEVSSKTEVSTDS*0


>SWS1_Geotria australis lamprey UV-sensitive retinal pigment lamprey
Characters in extant (living) species should never be confused with ancestral characters present at the time of divergence nodes (last common ancestors); conceivably these early diverging deuterostomes have lost opsin genes, perhaps due to a habitat shift to deep water, burrowing habitat, or nocturnal lifestyle. However the molecular evidence is quite clear that full-blown pentachromatic color vision and most other modern ciliary opsin classes first appeared during the evolutionary stem preceding lamprey divergence. These are demonstrably not 'new' genes but derived from gene duplication and divergence of still older opsins of ciliary class..
0 MSGDEEFYLFKNISKVGPWDGPQFHIAPKWAFYLQAAFMGFVFICGTPLNAIVLVVTIKYKKLRQPLNYILVNISAAGLVFCLFSISTVFVASMQGYFFLGPTICALEAFFGSLA 1
2 GLVTGWSLAFLAAERYIVICKPFGNFRFGSKHALVAVGLTWMLGLSVALPPFFGWSR 2
1 YIPEGLQCSCGPDWYTVGTKYKSEYYTYFLFVFCFVVPLSIIIFSYGSLLGTLRA 0
0 VAAQQQESASTQKAEREVSRMVIMMVASFCTCYVPYAALAVYMVTNRDHNIDLRFVTVPAFFSKASCVYNPLIYSFMNKQ 0
0 FRACILETVCGKPITDESETSSSRTEVSSVSTTQMIPG* 0


>SWS2_ornAna blue cone bp 2 gene tandem -FLNB--+MECP2 with MWS1 5 usual exons
The fossil record is unsatisfactory: less than 1 bilateran in 10,000 in Chengjiang and Burgess Shale fossils is even a candidate for deuterostomy. Low numbers of specimens and poor preservation conspire with career pressures and impact-seeking journals in egregiously misinterpreted data in the view of Hou, discoverer of the Chinese lagerstaette. Myllokunmingia is the best situation with 500 specimens; however Haikouichthys as supposed stem deuterostome, Metaspreggina as supposed post-Ediacaran, and Yunnanozoan generally are problematic, valid only in the eye of some beholder.
0 MHKTHRNLQNELPEDFFIPLPLDTDNITSLSPFLVPQTHLGGSGIFMSLAAFMFLLITLGFPINLLTVICTIKYKKLRSHLNYILVNLAVSNMLVVCVGSATAFYSFAHMYFVLGPTACKIEGFAATLG 1
2 GMVSLWSLAVIAFERFLVICKPLGNLSFRGTHAIFGCAATWVFGLAASLPPLFGWSR 2
1 YIPEGLQCSCGPDWYTTNNKWNNESYVIFLFSFCFGVPLSIIIFSYGRLLLTLRA 0
0 VAKQQEQSATTQKAEREVTKMVIVMVLGFLVCWLPYASFSLWVVTNRGQVFDLRMASIPSVFSKASTIYNPIIYVFMNKQ 0
0 FRSCMLKLVFCGKSPFGDEDEISGSSQATQVSSVSSSQVSPA* 0


>SWS2_galGal blue cone pigment galGal- ornAna+ homSap+
While signs of bilaterally disposed eyes are sometimes documentable, it does not follow these were image-forming eyes. Indeed contemporary Branchiostoma and tunicate larva have an eye-spot (ocellus); the genomes contain ciliary opsins but only clustering to ENCEPH and PPIN -- still a long ways from any imaging opsin. Echinoderms and hemichordates genomes also have opsins but even further diverged. Sea urchin genome encodes at least six opsins, four of these cluster classify to rhabdomeric, ciliary and Go-type. Tube feet are apparently the photosensory organ in adult urchins.
0 MHPPRPTTDLPEDFYIPMALDAPNITALSPFLVPQTHLGSPGLFRAMAAFMFLLIALGVPINTLTIFCTARFRKLRSHLNYILVNLALANLLVILVGSTTACYSFSQMYFALGPTACKIEGFAATLG 1
2 GMVSLWSLAVVAFERFLVICKPLGNFTFRGSHAVLGCVATWVLGFVASAPPLFGWSR 2
1 YIPEGLQCSCGPDWYTTDNKWHNESYVLFLFTFCFGVPLAIIVFSYGRLLITLRA 0
0 VARQQEQSATTQKADREVTKMVVVMVLGFLVCWAPYTAFALWVVTHRGRSFEVGLASIPSVFSKSSTVYNPVIYVLMNKQ 0
0 FRSCMLKLLFCGRSPFGDDEDVSGSSQATQVSSVSSSHVAPA* 0


>SWS2_Taeniopygia
The oldest known fossil lamprey, Priscomyzon, dates at 360 myr to the Devonian. Molecular clocks place lamprey appearance at approximately 430 myr, some 100 million years after Chengjiang and Burgess Shales fossil Lagerstaette formed. Like most soft tissues, eyes seldom leave a good fossil record, though bilateral placement might be reflected in bone orbits. Hagfish, sister group to lamprey, have imaging eyes but have not been studied; their opsins situation may be derived due to deepwater marine habitat (similarly deepwater coelacanth opsins are adapted to less scattered wavelengths, centered at420 nm).
0 MPKPREMRDELPEDFYIPMSLETPNLTALSPFLVPQTHLGSPGIFKAMAAFMFLLVLLGVPINALTVLCTAKYKKLRSHLNYILVNLAVANLLVVCVGSTTAFYSFSQMYFALGPLACKIEGFTATLG 1
2 GMVSLWSLAVVAFERFLVICKPLGNFTFRGSHAVLGCAITWIFGLIASLPPLFGWSR 2
1 YIPEGLQCSCGPDWYTTDNKWNNESYVIFLFCFCFGFPLTVIVFSYGRLLLTLRA 0
0 VAKQQEQSASTQKAEREVTKMVVVMVLGFLVCWLPYCSFALWVVTHRGHPFDLGLASIPSVFSKASTVYNPIIYVFMNKQ 0
0 FRSCMLKLVFCGRSPFGDEDDVSGSSQATQVSSVSSSQVSPA* 0


>SWS2_utaSta
The next-diverging chondrichthyes have inadequate data at GenBank -- only a few rhodopsin genes from skates and dogfish. This makes even fragmentary opsins from the partially sequenced elephantfish Callorhyncus milii quite valuable. Those 9 fragments and 3 from the lamprey genome are provided in the data section -- the opsin classifier tool can reliably type a fragment from a single mid-sized exon. Full length genes are preferable but these fragments serve to prove existence of various gene class at the time of a given divergence node. Further, they can validate certain rare genomic events provided the fragment happens to overlap the region of interest.
0 MHNSRPHSRDDLPEDFFIPMPLDVANITTLSPFLVPQTHLGSPALFMGMAAFMFLLIILGVPINVLTIFCTFKYKKLRSHLNYILVNLAVSNLLVVCIGSTTAFYSFAQMYFSLGPTACKIEGFAATLG 1
2 GMVSLWSLAVVAFERFLVICKPLGNFSFRGTHAIIGCIITWVFGLVASLPPLFGWSR 2
1 YIPEGLQCSCGPDWYTTNNKWNNESYVLFLFSFCFGVPLSVIIFSYGRLLLTLRA 0
0 VAKQQEQSATTQKAEREVTKMVVVMVMGFLVCWLPYASFALWVVTHRGEPFDVRLATIPSVFSKASSVYNPVIYVFMNKQ 0
0 FRSCMLKLVFCGKSPFGDEDDVSGSSQTTQVSSVSSSQVSPA* 0


>SWS2_Xenopus
On the other hand, thousands of high-quality Cambrian arthropod fossils unmistakably show stalked paired eyes. Fossil trilobite eyes have been much studied; these are better preserved due to calcite as lens crystalin. Imaging eyes of contemporary arthropods and lophotrochozoa are rhabdomeric, utilizing depolarizing Gq-type receptor, phospholipase C, phosphoinositol, diacylglycerol, and transient receptor potential TRP and TRPL channel signaling. However their genomes can also contain ciliary opsins, using hyperpolarizing Gt-type transducins and phosphodiesterase cGMP second-messaging (as well as Go-type gustducin ciliary opsins in other types of photoreceptors).
0 MSKGRPDLRMEMPDEFYVPIPLETTNISSLSPFLVPQTHLGTPGIFMSISAFMLFTIIFGFPLNLLTIICTVKYKKLRSHLNYILVNLAVANLIVICFGSTTAFYSFSQMYFSLGTLACKIEGFTATLG 1
2 GIIGLWSLAVVAFERFLVICKPMGNFTFRESHAVLGCILTWVIGLVAAIPPLLGWSR 2
1 YIPEGLQCSCGPDWYTVNNKWNNESYVLFLFCFCFGFPLAIIVFSYGRLLLALHA 0
0 VAKQQEQSATTQKAEREVTRMVIVMVVGFLVCWLPYASFALWAVTHRGELFDLRMSSVPSVFSKASTVYNPFIYIFMNRQ 0
0 FRSCMMKMIFCGKNPLGDDEETSVSGSTQVSSVSSSQIAPS* 0


>SWS2_danRer
Vertebrates are just the opposite, having crossed over to a near-exclusively ciliary opsin-based imaging system, while retaining rhabdomeric signaling in retinal ganglion cells and elsewhere. (A very recent report demonstrates very rare human and mouse [http://www.iovs.org/cgi/content/full/47/4/1636 cone cells expressing exclusively melanopsin;] however melanopsin cannot have given rise to ciliary cone opsins.)
0 MKQQQQTPELFEDFHMPITLDVSNISAYSPFLVPQDHLGHSGVFMGMSAFMLFLFIAGTAINVLTIVCTIQYKKLRSHLNYILVNLAISNLWVSVFGSSVAFYAFYKKYFVFGPIGCKIEGFTSTIG 1
2 GMVSLWSLAVVALERWLVICKPLGNFTFKTPHAIAGCILPWCMALAAGLPPLLGWSR 2
1 YIPEGLQCSCGPDWYTTNNKFNNESYVMFLFCFCFAVPFSTIVFCYGQLLITLKL 0
0 AAKAQADSASTQKAEREVTKMVVVMVFGFLICWGPYAIFAIWVVSNRGAPFDLRLATIPSCLCKASTVYNPVIYVLMNKQ 0
0 FRSCMMKMVFNKNIEEDEASSSSQVTQVSSVAPEK* 0


>SWS2_Takifugu
It must not be thought that bilaterans invented imaging eyes because much earlier diverging cubomedusan jellyfish such as Carybdea marsupialis has [[Opsin_evolution:_key_critters#Cubozoa:_Carybdea_marsupialis_.28jellyfish.29_.._0_opsins|4 eyestalks each with 6 photoreceptors of 4 types: simple eyespots, pigment cups, complex pigment cups with lenses, and camera-type eyes with a cornea, lens, and retina.]] This jellyfish chases, captures, and eats 'more advanced' teleost fish. This wing of cnidarians very much needs a genome project.
0 MRGVRQHEFQEDFYIPIPLDVDNITALSPFLVPQDHLGSPAVFYGMSAFMFFLFVAGTGINVLTIACTIQYKKLRSHLNYILVNLAFSNLLVTTVGSFTCFCCFFVRYMIVGPLGCKIEGFAATLG 1
2 GMVSLWSLAVVAFERWLVVCKPLGNFIFKPDHAIVCCIFTWFFALIISAPPLFGWSR 2
1 YIPEGFQCSCGPDWYTTGNKYNNESYVWFIFGFGFAVPLFVIVFCYSQLLVMLKS 0
0 AKAQAESASTQKAEREVTRMVVVMILGFLVCWLPYASFALWVVNNRGTPFDLRLATIPACFSKASTVYNPIIYVVLNKQ 0
0 FRSCMKKMLGMSGGDDEESSSQSVTEVSKVSPS* 0


>SWS2_Geotria australis lamprey blue-sensitive retinal pigment lamprey
Cnidarian opsins are becoming available from Hydra and Nematostella genomes and targeted hybridization experiments. Hydra may express a ciliary-type opsin in ectodermal sensory nerve cells whereas Nematostella has opsins classifying between melanopsin and encephalopsin. These distant opsin are very difficult to distinguish bioinformatically from non-opsins in the rhodopsin superfamily within GPCR, so it is exceedingly important to include controls because a somewhat unspecialized photoreceptor cell may also express other sensory system signaling non-opsins that are nonetheless genetically homologous.
0 MYQGKSTQVDDLPEDFYIPIALNVKNMSELSPFLVPQVHLGDSFIFYGMSAFMLFLVLAGFPLNFLTVFVTIKYKKLRSHLNYILVNLAIANLIVVCCGSTLAFYSFMHKYFILGPLFCKMEGFTATLG 1
2 GMLSLWSLAVLAFERCLVICKPFGNIAFRGTHALIRCGFAWAAAIAASTPPLFGWSR 2
1 YIPEGLQCSCGPDWYTTNNKYNNESYVMFLFIFCFGTPFTIIIVSYSKLILTLRA 0
0 AAAQQQESASTQKAEKEVSRMVVIMVGGFLVCWLPYASLALWIVFNRGSPFDLRLATIPSVFSKASTVYNPVIYIFLNKQ 0
0 FRSCMMKTIFCGKNPLGDDEDATSTTTQVSSVSTSQVAPA* 0


>LWS_ornAna LWS green cone -Ultra401:228,567-238,486
In summary, there is no evidence whatsoever -- and every reason to doubt from genomic analysis -- that deuterostomes had imaging eyes during the Cambrian. Despite this, a BBC series "Walking With Monsters" portrayed a school of 25 mm Haikouichthys attacking and wounding an Anomalocaris twenty times their size. It is easy to guess at a scientific advisory panel that envisions deuterostomes triumphing over protostomes. This recurrent anthropocentric fantasy is echoed in museum imagery of early mammals nimbly predating on dinosaur nests -- dioramas quietly dismantled after Yucatan meteorite discovery.
0 MTPAWNSGVYAARRRFEDEEDTTRTSVFVYTNSNNTR 1
2 DPFEGPNYHIAPRWAYNVTSLWMIFVVIASVFTNGLVLVATMKFKKLRHPLNWILVNLAVADLGETLIASTISVINQIFGYFILGHPMCVLEGYTVSLC 1
2 GITGLWSLSIISWERWIVVCKPFGNVKFDAKLAMVGIVFSWVWAAVWTAPPIFGWSR 2
1 YWPHGLKTSCGPDVFSGSSDPGVQSYMIVLMSTCCILPLSIIVLCYLQVWLAIRA 0
0 VAKQQKESESTQKAEKEVSRMVVVMILAYCFCWGPYTIFACFAAANPGYAFHPLAAALPAYFAKSATIYNPIIYVFMNRQ 0
0 FRNCIMQLFGKKVDDGSELSSTSRTEVSSVSSVSPA* 0


>LWS_galGal green iodopsin red cone long-wave-sensitive missing in assembly
Imaging eyes are not essential to survival; even today subterranean mammals such as blind mole rat flourish without them. Discounting ray-finned fish numbers, a very substantial proportion of all extant animal species lack imaging eyes 525 myr after the Cambrian. Of 33 animal phyla, one-third have no specialized organ for detecting light, one-third have light-sensitive organs, and the remaining 6 have imaging eyes (Cnidaria, Mollusca, Annelida, Onychophora, Arthropoda, and Chordata). Thus 82% of animal phyla have survived well over 500 myr without imaging eyes despite the supposedly unrelenting competition/predation from animals having them.
0 MAAWEAAFAARRRHEEEDTTRDSVFTYTNSNNTR 1
2 GPFEGPNYHIAPRWVYNLTSLWMIFVVAASVFTNGLVLVATWKFKKLRHPLNWILVNLAVADLGETVIASTISVINQISGYFILGHPMCVVEGYTVSAC 1
2 GITALWSLAIISWERWFVVCKPFGNIKFDGKLAVAGILFSWLWSCAWTAPPIFGWSR 2
1 YWPHGLKTSCGPDVFSGSSDPGVQSYMVVLMVTCCFFPLAIIILCYLQVSLAIRA 0
0 VAAQQKESESTQKAEKEVSRMVVVMIVAYCFCWGPYTFFACFAAANPGYAFHPLAAALPAYFAKSATIYNPIIYVFMNRQ 0
0 FRNCILQLFGKKVDDGSEVSTSRTEVSSVSNSSVSPA* 0


>LWS_anoCar Anolis
<br clear="all" />
0 MAGTVTEAWDVAVFAARRRNDEDDTTRDSLFTYTNSNNTR 1
2 GPFEGPNYHIAPRWVYNITSVWMIFVVIASIFTNGLVLVATAKFKKLRHPLNWILVNLAIADLGETVIASTISVINQISGYFILGHPMCVLEGYTVSTC 1
2 GISALWSLAVISWERWVVVCKPFGNVKFDAKLAVAGIVFSWVWSAVWTAPPVFGWSR 2
1 YWPHGLKTSCGPDVFSGSDDPGVLSYMIVLMITCCFIPLAVILLCYLQVWLAIRA 0
0 VAAQQKESESTQKAEKEVSRMVVVMIIAYCFCWGPYTVFACFAAANPGYAFHPLAAALPAYFAKSATIYNPIIYVFMNRQ 0
0 FRNCIMQLFGKKVDDGSELSSTSRTEVSSVSNSSVSPA* 0


>LWS_Lithochromis sp
=== Opsin Gene and Species Trees ===
0 MAEEWGKQSFAARRYHEDSTRGSAFAYTNSNNTR 1
2 DPFEGPNYHIAPRWIYNLATLWMFVVVVLSVFTNGLVLVATMKFKKLRHPLNWILVNLAIADLGETVFASTISVCNQFFGYFILGHPMCIFEGYVVSVC 1
2 GIAALWSLTIISWERWIVVCKPFGNVKFDAKWATAGIVFSWVWAAVWCAPPIFGWSR 2
1 YWPHGLKTSCGPDVFSGSEDPGVQSYMIVLMLTCCIFPLAIIILCYLAVWMAIRA 0
0 VAMQQKESESTQKAEREVSRMVVVMIVAYCVCWGPYTFFACFAAANPGYAFHPLAAAMPAYFAKSATIYNPIIYVFMNRQ 0
0 FRTCIMQLFGKQVDDGSEVSTSKTEVSSVAPA* 0


>LWS_Gasterosteus aculeatus
The phylogenetic tree below shows the presence or absence of various opsin genes in clade-representative species, as reflected in the collected reference sequences. The purpose is timing appearance (or disappearance) of a given class of opsin gene. For example, cone and rod opsins first appeared before lamprey divergence; otherwise they are absent from urochordates, cephalochordates, and earlier deuterostomes. Note however a given gene might appear absent because of a genome project gap, lack of experimental effort, insufficient or outdated bioinformatics, or species choice (ie present in a different representative of that clade). In other cases (eg platypus SWS1) pseudogene remnants or a syntenically proven deletion establish a gene as definitely absent.
0 MAEEWGKQAFAARRYNEDTTRGSMFVYTNSNNTK 1
2 DPFEGPNYHIAPRWVYNLSTLWMFIVVALSVFTNGLVLVATAKFKKLQHPLNWILVNLAIADLGETVFASTISVCNQFFGYFILGHPMCVFEGYVVSVC 1
2 GITALWSLTIISWERWIVVCKPFGNVKFDAKWATAGIVFSWIWSAVWCAPPIFGWSR 2
1 YWPHGLKTSCGPDVFSGSEDPGVQSYMIVLMITCCLIPLAIIILCYLAVWLAIRA 0
0 VAMQQKESESTQKAERDVSRMVVVMIVAYIVCWGPYTTFACFAAANPGYAFHPLAAAMPAYFAKSATIYNPVIYVFMNRQ 0
0 FRSCIMQLFGKEVDDGSEVSTsKTEVSSVAPA* 0


>LWS_Petromyzon maritimus lamprey traces key to intron 3 position and gapping
[[Image:TMTsurvivors.png]]
0 MTASWQGAMFAARRRQDDEDTTMESLFRYTNENNTK 1
<br clear="all" />
2 DPFEGPNYHIAPRWVFNLTSVWMIIVVVLSLFSNGLVLVATVKFKKLRHPLNWIIVNLAIADILETIFASTISVCNQVYGYFILGHPMCVFEGYVVSTC 1
      Opsin retention at 18 genetic loci over 540 million years (Jan 2009 update)
2 GIAGLWSLAIISWERWMVVCKPFGNIKFDGKIATILIVFSWVWPASWCSLPIFGWSR 2
 
1 YWPHGLKTSCGPDVFSGSTDPGVQSYMVVLMITCCFLPLSIIILCYLQVWLAIHS 0
  1 RHO1  petMar calMil takRub xenTro galGal anoCar ornAna monDom bosTau homSap RHO1
0 VAQQQKESETTQKAERDVSRMVVVMILAYVFCWGPYTFFACFAAANPGYSFHPIAAALPAYFAKGATIYNPIIYVFMNRQ 0
  2 RHO2  geoAus calMil danRer ...... galGal anoCar ...... ...... ...... ...... RHO2
0 FRNCILQLFGKKVDDGSEVSSSSRTEVSSVSNSSVSPA* 0
  3 SWS1  geoAus ...... danRer xenLae galGal anoCar :::::: monDom bosTau homSap SWS1
  4 SWS2  geoAus ...... gasAcu xenTro galGal anoCar ornAna ...... ...... ...... SWS2
  5 LWS    petMar calMil danRer xenTro galGal anoCar ornAna monDom bosTau homSap LWS
  6 VAOP  petMar calMil danRer xenTro galGal anoCar ...... ...... ...... ...... VAOP
  7 PIN    ------ calMil ...... xenTro galGal utaSta...... ...... ...... ...... PIN
  8 PPIN  petMar calMil danRer xenTro ...... anoCar ...... ...... ...... ...... PPIN
  9 PARIE  petMar ------ danRer xenTro ...... anoCar ...... ...... ...... ...... PARIE
10 ENCEPH petMar calMil danRer xenTro galGal anoCar ...... monDom :::::: homSap ENCEPH
11 TMT    ------ calMil danRer xenTro galGal anoCar ornAna monDom ...... ...... TMT
12 MEL1  petMar calMil danRer xenTro galGal anoCar ornAna monDom bosTau homSap MEL1
13 MEL2  ------ calMil danRer xenLae galGal anoCar ...... ...... ...... ...... MEL2
14 NEUR1  petMar calMil danRer xenTro galGal anoCar ornAna monDom bosTau homSap NEUR1
15 NEUR2  ------ calMil danRer xenTro galGal anoCar ...... ...... ...... ...... NEUR2
16 NEUR3  petMar calMil danRer xenTro galGal anoCar ...... ...... ...... ...... NEUR3
17 PER    ------ calMil danRer xenTro galGal anoCar ornAna monDom bosTau homSap PER
18 RGR    petMar calMil danRer xenTro galGal anoCar ornAna ...... bosTau homSap RGR
          1 3    15    17    17    16    18    7      8      7    8
 
  Notes: in low coverage genomes, missing data was sought in closely related species.
  Absence of data (---) is distinguished from strong evidence of absence (...).
  In rare cases, pseudogene debris is still detectable at syntenic location (:::)
  Gene loss is a mixture of deep stem loss (mammals) and recent lineage-specific loss.


>LWS_lamprey Lethenteron japonicum
The opsin gene trees below illustrate only a few of the myriad possibilities, even beginning with commonsense ordering (blast nearest neighbors). Because these gene families originated long ago and are only known from remotely related representatives in extant species with wildly differently mutational mechanisms and histories, the true tree cannot be reliably inferred from maximal likelihood. Indeed no two such attempts have ever come up with the same gene tree! Instead, we'll keep this set of gene trees in view until analysis of rare genomic events is completed
0 MTASWHGAVFAARRRNDDEDTTKDSIFRYTNENNTR 1
2 DPFEGPNYHIAPRWMFNLTSVWMIIVVVLSLFTNGLVLVATMKFKKLRHPLNWILVNLAIADILETIFASTISVCNQVFGYFILGHPMCVFEGYVVSTC 1
2 GIAGLWSLAIISWERWMVVCKPFGNIKFDGKIAIILIVFSWVWPACWCSLPIFGWSR 2
1 YWPHGLKTSCGPDVFSGSSDPGVQSYMVVLMVTCCFLPLSVIILCYLQVWLAIHS 0
0 VAQQQKESETTQKAERDVSRMVVVMILAYIFCWGPYTFFACYAAANPGYAFHPLTAALPAYFAKSATIYNPVIYVFMNRQ 0
0 FRNCIMQLFGKKVDDGSEVSSASRTEVSSVSNSSISPA*


>LWS_Geotria australis lamprey red-sensitive retinal pigment
[[Image:opsin_gene_trees.png|{left}|]]
0 MAQSWERAMFAARRRQDEDTTKGDLFRYTNENNTR 1
2 DPFEGPNYHIAPRWMYNLTSFWMIIVVILSLFTNGLVLVATLKFKKLRHPLNWILVNLAIADIGETIFASTVSVVNQIFGYFILGHPLCVFEGFTVSVC 1
2 GITALWSLAIISFERWMVVCKPFGNLKFDGKVAIVLIIFSWAWSAGWCAPPIFGWSR 2
1 YWPHGLKTSCGPDVFSGSTDPGVQSYMVVLMITCCFIPLALIIICYLQVWLAIHT 0
0 VAQQQKESETTQKAERDVSRMVVVMIFAYIFCWGPYTFFACFAAANPGYAFHPLAAALPAYFAKSATIYNPIIYVFMNRQ 0
0 FRNCIMQLFGKKVDDGSEVSSSARTEVSSVSNSSVSPA* 0


>PIN_galGal pinopsin pineal pigment non-visual homSap- RPH3AL DOC2B PIN TEX14 RAD51C
<br clear="all" />
0 MSSNSSQAPPNGTPGPFDGPQWPYQAPQSTYVGVAVLMGTVVACASVVNGLVIVVSICYKKLRSPLNYILVNLAVADLLVTLCGSSVSLSNNINGFFVFGRRMCELEGFMVSLT 1
2 GIVGLWSLAILALERYVVVCRPLGDFQFQRRHAVSGCAFTWGWALLWSTPPLLGWSSYVPE 1
2 GLRTSCGPNWYTGGSNNNSYILSLFVTCFVLPLSLILFSYTNLLLTLRA 0
0 AAAQQKEADTTQRAEREVTRMVIVMVMAFLLCWLPYSTFALVVATHKGIIIQPVLASLPSYFSKTATVYNPIIYVFMNKQ 0
0 FQSCLLEMLCCGYQPQRTGKASPGTPGPHADVTAAGLRNKVMPAHPV* 0


>PIN_Uta stansburiana pinopsin missing in Anole genome
=== Using the Opsin Classifier ===
0 MVNEWSNATPGPFDGPQWPYLAPRSIYTSVAVLMGLVVVSAAFVNGLVIVVSIQYKKLRSPLNYILVNLAIADLLVTSFGSTLSFANNIYGFFVLGQTACEFEGFMVSLT 1
2 GIVGLWSLAILAFERYLVICKPVGDFRFQQRHAVFGCVFTWMWSLVWTLPPLFGWSSYVPE 1
2 GLRTSCGPNWYTGGSGNNSYIMALFVTCFALPLGMIIFSYASLLLTLRA 0
0 VATQQKEVETTQQAEKEVTRRVIAMVMAFLVCWLPYASFAMVVATNKDLVIQPALASLPSYFSKTATVYNPIIYVFMNKQ 0
0 FRSCLLSTMSCGHRPRGAQETTPAMISIPQGPTSALQGSRNKVTPSASEGSGNEAIPS* 0


>PIN_Phelsuma madagascariensis gekko
Below is the primary collection of opsin protein sequences. Here "fields" in the fasta header show gene name, genus, species, common name, heterotrimeric G protein alpha subunit used in signaling, intron structure, synteny (2 flanking genes on each side of the opsin), indel status, sequence length, lambda max, and comment field. The 230-odd sequences are now organized into deuterostomes, lophotrochozoans, and ecdysozoan divisions, further broken refined into ciliary, rhabdomeric, or neither. Even with the full set copied into the [http://www.proweb.org/proweb/Tools/WU-blast.html uBlast], a novel opsin candidate can be classified in 6 seconds over just a conventional DSL internet connection.
0 MHVQMANASQASLKNGTLSPFDGPQWPHRASRRVYTSLAALMGVVVLSASLANGLVIAVSVRFKRLRSPLNYILVNLATADLLVTFFGSIISFVNNAVGFFVFGKTACRFEGFMVSLT 1
2 GIVGLWSLAILAFERYLVICKPVGDFQFQRRHAVIGCLYTWGWSLIWTVPPLFGWSSYVPE 1
2 GLGTSCGPNWYMGGTNNNSYIVALFVTCFALPLSMILFSYANLLLTLRA 0
0 VAAQQKEQETTQRAEKEVTRMVITMVMAFLVCWLPYATFAMVVATTKDLSIQPGLASLPSYFSKTATVYNPIIYVFMNKQ 0
0 FRSCLLNTVSCGRIPQTMPGTPATTAVRGGFVLTSEGRGNKVASTELHS* 0


>PIN_Podarcis sicula pinopsin mRNA ruin lizard
On 26 Nov 07, I added 41 new sequences, mostly arthropod rhabdomeric imaging opsins, extracting them from a 2007 [http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed&pubmedid=17684563 pancrustacean opsin] paper, using the much-studied accessions in their Table 1, as ordered phylogenetically according to their Fig.3, with subsampling to avoid too-close sequences and narrow lineage-specific expansions. This involved replacing a few defective accessions and partial sequences with comparable complete ones, favoring sequences with completed or planned genome projects which can be directly intronated and their synteny determined. Lambda max values were helpfully compiled for all these opsins by the original authors.
0 MQASNASWVEVRNRTPGPFEGPQWPYLAPQSTYISVAVLMGLVVISATLVNGLVIVVSVQFKKLRSPLNYVLVNLAVADLLVTFFGSTISFVNNAQGFFIFGQATCEFEGFMVSLT 1
2 GIVGLWSLAILAFERYLVICKPVGDFRFPARHAVLGCAFTWGWSFVWTVPPLLGWSSYVPE 1
2 GLRTSCGPNWYSGGSSNNSYIMTLFVTCFAMPLSTILFSYANLLMTLRT 0
0 VAAQQKEQETTQRAEREVTRMVVAMVAAFLVCWLPYASFAMVVATHKDLAIRPALASLPSYFSKTATVYNPIIYVFMNKQ 0
0 FRSCLLYKMSCGHRALSSQDTTPAGISLPGRLTTSASKGSRNQVSPS* 0


>PIN_xenTro
This significantly upgrades the resolving power of the Opsin Classifier vis-a-vis these new classes of protostome opsins. It raises thorny nomenclature issues because of short-sighted historic uses such as rhodopsin or LWS for both fruitfly and human genes. These are indeed vaguely homologous in the distant pre-Bilateran GPCR past but are certainly not orthologous as implied by the same common name. The <span style="color: #990099;">definition of orthology requires genes under comparison in extant species to descend from a single parent gene in their last common ancestor.</span> If this LCA requirement is relaxed, the entire set of a thousand GPCR all become orthologous.
0 MRAGNMSAYEAPGPYDGPQWPHLAPRSTFLTVAAVMCMVVILAFFVNGLVIVVTLKYKKLRSPLNYILVNLAIANLLVTIFGSSVSFSNNVVGYFFMGKTMCEFEGFMVSLT 1
2 GIVGLWSLAILAFERYLVICKPMGDFRFQQKHAILGCSFTWVWSFIWTSPPLFGWCSYVPE 1
Additional ecdysozoan and lophotrochozoan opsins are needed, whatever new that can be extracted from invertebrate genome projects; some of these will prove ciliary and conversely some deuterostome opsins rhabdomeric. Melanopsin/encephalopsin appear at the heart of the Big Switchover that took place in chordates -- their imaging opsins did not arise from gene duplication and divergence of anything we see among contemporary protostomal imaging opsins or any reconstructed ancestor.
2 GLRTSCGPNWYTGGTNNNSYIMALFLTCFIMPLSTIIFSYSNLLMALRA 0
0 VAAQQKDSETTQRAEKEVTRMVIAMVLAFLICWLPYASFAVVVAVNKDVVIEPTVASLPSYFSKTATVYNPIIYVFMNKQ 0
0 FRNCLMTLLCCGRSFGDDETSSASGRTDVTSVSEAGGNKVTPA* 0


>PIN_Bufo japonicus toad classifies somewhat oddly
In fact, none of the opsin genes in Ur-bilatera destined to become rhabdomeric imaging opsins in living arthropods (even all of protostomia) seems to have descended directly to any deuterostome. It may turn out that none of the opsin genes in Ur-Bilatera destined to become ciliary imaging opsins in living vertebrates (even all of Deuterostomia) survived in any protostome. The pool of GPCR genes was already large and signaling diversified across gene copies. However lophotrochozoa and basal ecdysozoan ciliary opsins are still largely unexplored. A similarly 'bad' Venn diagram could hold in Ur-eumetazoa. Here the only two cnidarians with sequence data (Hydra and Nematostella) were not the best choices for studying opsin evolution. We may have to wait for genome sequencing of a full-featured cubomedusan.
0 MHSANMSALETPGPFEGPQWPHVAPRSTYLTVAVLMGMVVFLAFFVNGMVIVVSLKYKKLRSPLNYILVNLAVADILVTMFGSTVSFHNNIFGFFTLGKLVCELEGFVVSLT 1
2 GIVGLWSLAILAFERYIVICKPMGDFRFQQRHAVMGCAFTWIWAFLWTSPPLIGWCSYVPE 1
2 GLGTSCGPNWYTGGTNNNSYILALFTTCFMMPLTTIIFSYSNLLLALRA 0
0 VAAQQKESETTQRAEREVTRMVIAMVLAFLICWLPYAVFAIVMASNKNVVIDPTLASMPSYFSKTATVYNPVIYVFMNKQ 0
0 FRDCLTKLLCCGRNPFGEDETSTTSGRTDVTSVSEGGGNKVTPA* 0


>VAOP_galGal Gallus gallus exon 1 genbank error + too short + frameshift INPP5A NKX6 VAOP ALDH18A stubbed in terminal finch
Please do not add text or edit sequences at this time, even though genomeWiki encourages participation; consider starting a fresh page to hold your contributions. After finishing the first round of articles, everything will be revisited and reorganized at a second pass.
0 MDVFRALGNESLLSNSSGPARWDPFHHPLDSIQPWHFRLVAAVMFVVTSLSLAENLAVILVTFKFKQLRQPVNYVIVNLSVADFLVSLTGGTISFLANLKGYFYMGHWACVLEGFAVTFF 1
2 GIVALWSLALLAFERYIVICRPVGNMRLRGKHAAQGIAFVWTFSFIWTIPPTMGWSSYTTSKIGTTCEPNW 2
1 YSGAYNDRSYIIAFFTTCFIVPLLVILVSYGKLLQKLRK 0
0 VSNTQGRLRTARKPERQVTRMVVVMIIAFLICWMPYAVFSILATAYPSIELDPHLAAIPAFFSKTATVYNPIIYVFMNKQ 0
0 FRMCLIQMFKCSAIETAESNMNPTSERATLTQDKRDSQLSVMAVRSTILKRKTGDEHRADDLWLFRQLQKPKCVPCRAGDGS* 0


>VAOP_anoCar Anole INPP5A NKX6 VAOP new
=== Curated opsin reference sequences ===
0 MAGLRREAENDSWLFDPSSSSAPFDPFLQPLDIIEPWNFHLISALMFVVTLFSLSENFTVILVTIKFKQLRQPLNYVIVNLSVADFLVSLIGGTISFSTNLKGYFYMGHWACVLEGFAVTFF 1
2 GIVALWSLALLAFERYVVICRPLGNMRLNGKHAALGVAFVWIFSFIWTVPPTMGWSSYTTSKIGTTCEPNW 2
1 YSGDYNDHTFIITFFTTCFILPLLVILVSYGKLMRKLRK 0
0 VSDTQGRLGTTRKPERQVTGMVVIMILAFLICWSPYAAFSILVTACPSIELDPRLAAIPAFFSKTATVYNPVIYVFMNNQ 0
0 FRKCLVQLFQCSSQETMDANVNPISEKDTLTHTKHCGEMSTVAAHVIVFNPRSEDEQGSCQSFAQLAISENKVYPL* 0


>VAOP_xenTro frog new lost synteny GSTO1 VAOP C10ORF92
The 460 manually curated opsin sequences below provides an optimal set for phylogenetic research in opsin evolution. These sequences have been collected from over 75 metazoan genome projects in addition to those extracted comprehensively from GenBank. Errors in genome assembly, flawed or missing annotation and mistakes in gene models have largely been corrected by advanced bioinformatic methods. (GenBank data cannot be used as it stands.) An opsin sequences is included only if it provides more information than clutter -- gene expansions limited to narrow clades and over-sampled loci are restricted to proxy representatives.
0 MPTNVSLLATPENSTVWNPFTGPLKTIEAWNFHLLAALMFVVTSLSIAENFIVILVTAKFKQLRQPLNYIIVNLSVADFLVSVIGGTISIATNSRGYFYLGSWACVLEGFAVTFF 1
2 GIVALWSLSVLAFERYIVICRPLGNLRLQGKHSALAIIFVWVFSFVWTIPPTMGWSSYTTSKIGTTCEPNW 2
1 YSGEMRDHTYIITFLTTCFVFPLLVIFMSYGKLMRKLRK 0
0 VSDTQGRLGSTRKPEKEVTRMVVIMILAFLICWTPYAAFSILITAHPTIDLDPRLAAIPAFFAKTASMYNPIIYVYMNKQ 0
0 FRRCLYQMFNINDPEAKESNLNPTSERGVLTRNNNGGEMLAIATHITSSAVTNREEEKSSSNSFAHIPVSDNKVCPM*


>VAOP_Danio rerio vertebrate ancient long opsin assembly missing exon 3 no synteny
However eight opsin genetic loci -- some new -- have greatly expanded reference sequence collections within separate articles. These explore more fine-grained opsin evolution restricted to the 48 vertebrate genomes available on 10 Jan 2010. Data from complete genomes offers four advantages over transcripts, namely it can provide regulatory regions, introns, flanking gene synteny, and exhaustive opsin paralog sets present in the organism.
0 MEASSAAVNAVSPAEDPFSAPLSSIAPWNYSVLAALMFVVTALSLSENFTVMLVTFRFQQLRQPLNYIIVNLSLADFLVSLTGGSISFLTNYHGYFFLGKWACVLEGFAVTFF 1
2 GIVALWSLAVLAFERFFVICRPLGNIRLRGKHAALGLVFVWSFSFIWTVPPVLGWSSYTVSRIGTTCEPNW 2
* [[Opsin_evolution:_LWS_PhyloSNPs|LWS reference sequences from 95 species]]
1 YSGNFHDHTFIITLFSTCFIFPLGVIIVCYCKLIRKLRK 0
* [[Opsin_evolution:_Encephalopsin_gene_loss|Encephalopsin and TMT: yet more opsins lost in mammals]]
0 VSNTHGRLGNARKPERQVTRMVVVMIVAFMVAWTPYAAFSIIITAHPSMHVDPRLAAIPAFVAKTAAVYNPIIYVFMNKQ 0
* [[Opsin_evolution:_RGR_phyloSNPs|RGR opsin: abrupt change in DRY motif in boreoeutheres]]
0 FRKCLVQLLSCSKVTVVEGNNNQTTERAGMTSGSNTGEMSAIAARVSVPKTEENPGDRSTFSHIPIPENKVCPM*
* [[Opsin_evolution:_Peropsin_phyloSNPs|Peropsin: phyloSNPs in peropsin evolution]]
* [[Opsin_evolution:_Neuropsin_phyloSNPs|Neuropsin (OPN5): comparative genomics of 52 deuterostome genes and three new paralogs NEUR2, NEUR3, NEUR4]]


>VAOP_Rutilus rutilus (roach minnow) vertebrate ancient opsin
The fasta header lines below are structured as a flatfile database. Fields are separated by spaces rather than tabs (which display poorly). The first field (all that will be retained by most web alignment tools) gives the gene name together with a 3+3 genus-species latin name code.
0 MELFPVAVNGVSHAEDPFSGPLTFIAPWNYKVLATLMFVVTAASLSENFAVMLVTFRFTQLRKPLNYIIVNLSLADFLVSLTGGTISFLTNYHGYFFLGKWACVLEGFAVTYF 1
2 GIVALWSLAVLAFERFFVICRPLGNIRLRGKHAALGLLFVWTFSFIWTIPPVLGWSSYTVSKIGTTCEPNW 2
1 YSGNFHDHTFIIAFFITCFILPLGVIVVCYCKLIKKLRK 0
0 VSNTHGRLGNARKPERQVTRMVVVMIVAFMVAWTPYAAFSIVVTAHPSIHLDPRLAAAPAFFSKTAAVYNPVIYVFMNKQ 0
0 FRKCLVQLLRCRDVTIIEGNINQTSERQGMTNESHTGEMSTIASRIPKDGSIPEKTQEHPGERRSLAHIPIPENKVCPM* 0


>VAOP_Petromyzon marinus 5 exons validated #123 in traces  pineal gland-specific opsin AH006524
These gene names mostly comply with international conventions and historic first-use but do not perpetuate poor terminology (use of already-assigned gene names, obtuse acronyms, greek letters, roman numerals, hyphens, subscripts, calling everything rhodopsin and so forth). Paralog subfamilies are numbered sequentially; recent gene duplicates (limited in phylogenetic distribution) are distinguished by lower case letters with different letters denoting those demonstrably arising from whole genome duplications. The nomenclature closely follows the opsin gene tree, indeed implicitly provides it (other than deep branching).
0 MDALQESPPSHHSLPSALPSATGGNGTVATMHNPFERPLEGIAPWNFTMLAALMGTITALSLGENFAVIVVTARFRQLRQPLNYVLVNLAAADLLVSAIGGSVSFFTNIKGYFFLGVHACVLEGFAVTYF 1
2 GVVALWSLALLAFERYFVICRPLGNFRLQSKHAVLGLAVVWVFSLACTLPPVLGWSSYRPSMIGTTCEPNW 2
1 YSGELHDHTFILMFFSTCFIFPLAVIFFSYGKLIQKLKK 0
0 ASETQRGLESTRRAEQQVTRMVVVMILAFLVCWMPYATFSIVVTACPTIHLDPLLAAVPAFFSKTATVYNPVIYIFMNKQ 0
0 FRDCFVQVLPCKGLKKVSATQTAGAQDTEHTASVNTQSPGNRHNIALAAGSLRFTGAVAPSPATGVVEPTMSAAGSMGAPPNKSTAPCQQQGQQQQQQGTPIPAITHVQPLLTHSESVSKICPV* 0


>PPIN_anaCar Anoles parapinopsin new ACTR8 SELK PPIN CACNA2D3 PPIN syntenic region deleted in chicken VL 00 FNQVAKVGLAQRGSTT too many
Each major branch of the metazoan opsin gene tree is assigned a distinct short gene name that evokes its common name without need for explanatory table. Some names require periodic revision as more information emerges on their phylogenetic origin. While a later field of the fasta header does supply synonomy, should any confusion over sequence nomenclature ever arise, it is best resolved by text query of a sequence snippet using web browser search capability.
0 MDSLDTNTLSPNASTVRVVLMPRIGYTIIAIIMATSCTLSVILNTAVIAITIKYRQLRQPINYSLVNLAIADLGAALLGGSLNVETNAVGYYNLGRVGCVTEGFAMAFF 1
2 GIVALCTIAVIAVDRAIVIAKPMGTITFTTRKAMIGVAVSWIWSLVWNTPPLFGWGGYQMEGVMTSCAPDWANSDPINVSYIICYFLFCFTIPFITILASYGYLIWT 0
0 VAKVGLAQRGSTTKAEAQVSRMVIVMVMAFLICWLPYATFALVVVGNPQIYINPIIATIPMYMAKSSTFYNPIIYIFMNKQ 0
0 FRDCLVRCLLCGRNPCASEQTDEDDLEVSTIAPAPSSRRGKVAPV* 0


>PPIN_Xenopus tropicalis bistable UV pigment lamprey pineal broken contigs ACTR8 SELK PPIN CACNA2D3 genome only last 2
The next three fields provide the full genus and species names (per GenBank taxonomy) and then a one-word common name. The latter can provide helpful orientation when the genus/species is unfamiliar. Next comes a field providing three units of higher order taxonomic nomenclature that allow phylogenetic subsetting of the database. For example chicken receives Deut.Saur.Arch as a deuterostome, sauropod like lizard, but archeosaur like finch but unlike lizard. This field implicitly places all the sequences on a phylogenetic tree. It assumes, unlike GenBank, that ecdysozoa and lophotrochozoa are the correct partition of protostomes.
0 MADEALLPPMMNVTNEEMHPGKVLMPRIGYTILALIMAVFCAAALFLNVTVIVVTFKYRQLRHPINYSLVNLAIADLGVTVLGGALTVETNAVGYFNLGRVGCVIEGFAVAFF 1
2 GIAALCTIAVIALDRVFVVCKPMGTLTFTPKQALAGIAASWIWSLIWNTPPLFGWGSYELEGVMTSCAPNWYSADPVNMSYIVCYFSFCFAIPFLIIVGSYGYLMWT 0
0 LRQVAKLGVAEGGTTSKAEVQVSRMVIVMILAFLVCWLPYAAFAMTVVANPGMHIDPIIATVPMYLTKTSTVYNPIIYIFMNKQ 0
0 FQECVIPFLFCGRNPWAAEKSSSMETSISVTSGTPTKRGQVAPA* 0


>PPIN_Ictalurus punctatus (channel catfish) parapinopsin index sequence
The next two fields provide a GenBank accession and PubMed identifier if any exist. The reference sequences here do not follow GenBank when it errs (as it often does, eg by retaining introns, omitting exons, extending the 'first' exon to a false initiating methionine, extending the 'final' exon to a false stop codon, leapfrogging across tandem genes to form chimeric genes). Many uncurated gene models are poor quality. However even these entries can provide historic credits and supplement the protein entries below with underlying dna.
0 MASIILINFSETDTLHLGSVNDHIMPRIGYTILSIIMALSSTFGIILNMVVIIVTVRYKQLRQPLNYALVNLAVADLGCPVFGGLLTAVTNAMGYFSLGRVGCVLEGFAVAFF 1
2 GIAGLCSVAVIAVDRYMVVCRPLGAVMFQTKHALAGVVFSWVWSFIWNTPPLFGWGSYQLEGVMTSCAPNWYRRDPVNVSYILCYFMLCFALPFATIIFSYMHLLHT 0
0 LWQVAKLQVADSGSTAKVEVQVARMVVIMVMAFLLTWLPYAAFALTVIIDSNIYINPVIGTIPAYLAKSSTVFNPIIYIFMNRQ 0
0 FRDYALPCLLCGKNPWAAKEGRDSDTNTLTTTVSKNTSVSPL* 0


>PPIN_Danio rerio parapinopsin [not checked wgd or synteny]
The PubMed identifier links to a recent journal article with substantive experimental data specifically relevant to the opsin sequence at hand. Such papers review earlier literature and most hubs also provide subsequent papers citing the initial paper. This allows rapid collection of all work pertaining to a given opsin gene. Papers are not cited that simply sequenced tens of thousands of transcripts without characterization or comment on fortuitously included opsins.
0 MESETSTAASGSIAEVMPRMGYTILAVIIGVFSVCGVILNVTVITVTLKYKQLRQPLNFALVNLAVADLGCAVFGGLPTVVTNAMGYFSLGRVGCVLEGFAVAFF 1
<br clear="all">
2 GIAALCSVAVIALERCMVVCRPVGSISFQTRHAVFGVAVSWLWSFIWNTPPLFGWGRLQLEGVRTSCAPDWYSRDLANVSFIVCYFLLCFALPFSVIVYSYTRLLWT 0
0 LRQVSRLQVCEGGSAARAEAQVSCMVVVMILAFLLTWLPYASFALCVILIPELYIDPVIATVPMYLTKSSTVFNPIIYIFMNRQ 0
0 FRDRALPFLLCGRNPWAAEAEEEEEETTVSSVSRSTSVSPA* 0


>PPIN_Oncorhynchus mykiss
The next field provides a measure of sequence completeness. About 1 sequence in 7 is fragmentary (but often not affecting the 7-transmembrane core). While important in proving that a given orthology class exists in a given clade (as are recent pseudogenes) and helpful in defining conserved residues in local alignments, these sequences cannot currently be completed. Reasons include too-rapid divergence of non-membrane regions, gaps in assembly coverage of individual exons, uncertainty in exon boundaries, and incomplete transcripts.
0 MDHQQLLPNLHGNISSSPGSVSEALLSRTGFTILAVIIGVFSVSGVCMNVLVIMVTMRHRKLRQPLNYALVNLAVADLGCALFGGLPTMVTNAMGYFSMGRLGCVLEGFAVAFF 1
2 GIAGLCSVAVIAVDRYVVVCRPMGAVMFQTRHAVGGVVLSWVWSFLWNTPPLFGWGSFELEGVRTSCSPNWYSREPGNMSYIILYFLLCFAIPFSIIMVSYARILFT 0
0 LHQVSKLKVLEGNSTTRVEIQVVRMVVVMVMAFLLSWLPYAAFALSVILDPSLHINPLIATVPMYLAKSSTVYNPIIYVFMNRQ 0
0 FRDCAVPFLLCGLNPWASEPVGSEADTALSSVSKNPRVSPQ*


>PPIN_Lethenteron japonicum lamprey bistable pineal UV/green aligns perfectly
[[Image:GabgComplexity.jpg|left]]
0 MENLTSLDLLPNGEVPLMPRYGFTILAVIMAVFTIASLVLNSTVVIVTLRHRQLRHPLNFSLVNLAVADLGVTVFGASLVVETNAVGYFNLGRVGCVIEGFAVAFF 1
2 GIAALCTIAVIAVDRFVVVCKPLGTLMFTRRHALLGIAWAWLWSFVWNTPPLFGWGSYELEGVRTSCAPDWYSRDPANVSYITSYFAFCFAIPFLVIVVAYGRLMWT 0
0 LHQVAKLGMGESGSTAKAEAQVSRMVVVMVVAFLVCWLPYALFAMIVVTKPDVYIDPVIATLPMYLTKTSTVYNPIIYIFMNRQ 0
0 FRDCAVPFLLCGRNPWAEPSSESATAASTSATSVTLASAPGQVSPS* 0


>PPINa_Ciona intestinalis parapinopsin 8 mostly odd exons 88  +- 200671 202490 1820 opsin1 larval ocellus
The following field suggests a Galpha signaling partner for each opsin, important to understanding both structure and function. This is more wish-list than established fact because the rare cases known from direct experimental work have merely been extended below using homology to not-too-divergent orthologs in fairly closely related species -- even though the reliability of this procedure remains untested.
0 MNQWLETIMNERKFEIVNSSLQG 2
1 LLKPDSLGMDHDVTPTVDLTDGVPQCKDLNPYVLKGDGWVPQHISRANRSTYSFLCVYMTFVFLLSCSLNILVIVATLKNK 0
0 VLRQPLNYIIVNLAVVDLLSGFVGGFISIAANGAGYFFWGKTMCQIEGYFVSNFGVTGLL 0
0 SIAVMAFERYFVICKPFGPVRFEEKHSIFGIV 0
0 ITWVWSMFWNTPPLIFWDGYDTEGLGTSCAPNWFVKEKRERLFIILYFVFCFVIPLAVIMICYGKLILTLRQ 0
0 IAKESSLSGGTSPEGEVTKMVVVMVTAFVFCWLPYAAFAMYNVVNPEAQ 0
0 IDYALGAAPAFFAKTATIYNPLIYIGLNRQ 0
0 FRDCVVRMIFNGRNPWVDELVGSQVSSTGSQLTAVSSNKVAPA* 0


>PPINb_Ciona intestinalis 137 +- 67340 71147 3808 new 61% classifies perhaps as PIN jgi gene model wrong both ends
Indeed, the opsin literature is confused over what this classification should even mean, the options being (1) the specific Galpha gene product(s) physically docking to the cytoplasmic face of the opsin, (2) merely a gene tree subclade (eg Gs) of interacting Galpha protein whatever that might mean within a [[Opsin_evolution:_transducins|complicated gene duplication tree]] itself scarcely comparable over metazoa and already inadequate to resolve rod and cone GNAT transducins, (3) the small molecule produced that does the actual signaling (eg cyclic nucleotide or phosphoinositol), or (4) the character of downstream signaling ultimately produced (eg inhibitory).
0 MTTAETTTECYEKNPYIRNEMGWVPKHILIAERHIYTILAVYMTFIFLLAVSLNGFVIIATMKNK 0
0 KLRQPLNYIIINLSIADFLSGLVGGFIGMISNSAGYFYFGKTVCILEGYIVSVA 1
2 GVCGLMSISVMAFERYFVVCKPYGPFTLTNTHAAL 1
2 GIGFTWTWSVLWSTPGLIWLDGYVPEGLGTSCAPNWFSKNK 2
1 SERIFIFVYFVFCFFIPLLVIIICYGKIVLFLKQVSLY 0
0 ATRQSSASSNRQADNKVTKMVLVMISAFLICWTPYGVLSLYNAINPDKQ 0
0 LDYGLGAVPVFFAKTANIYNPLIYIGLNKQ 0
0 FRDGVIKMVFRGRNPWAEEMSTQQRQRSTEAGQPIVSNEV* 0


>PPIN2_Ciona savignyi new
Here the issue revolves around what is experimentally measurable -- opsins are not tested in a biochemically defined reconstituted system against individual Galpha proteins purified from the cognate species but rather signaling is characterized indirectly via the effect of some inhibitor or output of small molecule. While it appears that all opsin loci retain the universal features of GPCR signaling, it hasn't actually been established that all do in fact signal (rather than just serve as non-signaling photoisomerases in intermediary metabolism of retinoids).
46 IPQNYSNGNPYATTDSGWVPEHIEIANRSTYSGLCVFMSFVFVLAVPLNLLVIVATYKNKV 104
106 LRRPINYIIVNLAVADLTCSVVGGLLGVLNNGAGYYFLGKSVCIFEGYVMSVTG 162
149 KISSFKKISLGVCGILSITVMAFERYFVVCKPFGQTNLKWSHAITG 194
187 ENVNAMFSLGIVFTWTWSVIWHTPGLFFWNGYEPEGFGTSCAPNWFSQQKR 235
236 ERIFIFAYFAFCFLTPLTIIFACYLKLILFIRKVS 270
269 VSKKSMVNEADRRDFEVTRMVFVMIAAFLICWLPYGCLSMYNAIHPD 315
317 QLSYGIGSVPAFFAKTATIYNPIIYMGLNKKVIRMYILN 358
348 FRDGVIRMLFKGRNPWLDGRNTTSSTSTRAQ 378


>PARIE_Uta stansburiana lizard some minor problems shift in counterion
The next fields provide syntenic gene order (when known and relevant to a research issue), alternative gene names, tissues of expression, percent identity to nearest neighbor, and unstructured miscellaneous comments. Lambda-max peak adsorption could be added though it has been measured by a mix of techniques  and is not necessarily reliably calculated from classical tuning residues in less-familiar opsin classes. Length in amino acids is no longer provided because it does not satisfactorily explain fragmentary entries nor the run-on amino and carboxy termini in some opsin classes.
0 MENDSSLATELAEGAIVKPTIFPKAGYGVLAFLMFLNALFSIFNNSLVIAVTLKNPQLRNPINIFILNLSFSDLMMSLCGTTIVIATNYYGYFYLGRKFCIFQGFAVNYF 1
2 GIVSLWSLTILAYERYNVVCQPLGTLQMSTKRGYQLLGFIWVFCLFWAVVPLFGWSSYGPEGVQTSCSIGWEERSWSNYSYLIVYFLSCFFIPVLIIGFSYGNVIRSLHG 0
Adherence to rigid database format drops off after the early fields because the information is just not available or predictable for many entries. However the structure still suffices for routine queries such as 'how many opsins do tunicates have' or 'which protostomes have ciliary opsins'. Note the fasta header lines are easily isolated by pasting the entire database (including sequence lines) into a spreadsheet and sorting to collect lines beginning with '>'. The fields can be separated cleanly into columns by replacing spaces with tabs.
0 LNKKVEQLGGKSSPEEEFRAVIMVLVMVVAFLICWLPYTVFALIVVFNPALNISPLAATIPTYLSKTSPVYNPIIYIFLNKQ 0
0 FRDCAVEFITCGQVVLTSPEEDISTSAIPVEGKGPCKINQVTPV* 0


>PARIE_Anole carolinensis KERA DCN BTG1 PARIE EEA1 NUDT4
The protein sequences themselves are broken into their constituent exons. The numbering indicates [[Opsin_evolution:_ancestral_introns|phase]] (ie basepair overhang), a deeply conserved invariant useful in distinguishing orthology classes and gene tree divisions. All opsins in all species use standard GT-AG splice junctions. Alternate splicing within the core protein may occur but never produces functional protein. The exon structures in genomic species have been determined individually by tblastn and those of non-genomic species predicted by homology.
0 MENESSLVLEGAEGYIVRPTIFPRAGYGVLAFLMFINALFSLFNNFLVIAVTLKNPQLRNPINIFILNLSFSDLMMSICGTTIVIATNYHGYFYLGRRFCIFQGFAVNYF 1
2 GIVSLWSLTILAYERYNVVCQPLGTLQMSTQRAYQLLGFIWVFCLFWAVVPLFGWSSYGPEGVQTSCSIGWEERSWNNYSYLIVYFLSCFFIPVLIIGFSYGNVIRSLHG 0
0 LNKKVEQLGGKSNPEEEFRAVIMVLVMVVAFLICWLPYTLFALTVVFNPALNISPLAATIPTYLSKTSPVYNPIIYIFLNKE 0
0 FRECAVEFITCGKVVLTSPEEDISTSAISDEGIAPCKINQVTPV* 0


>PARIE_Xenopus tropicalis parietopsin
Full length genes beginning with an initial methionine and ending with a stop codon are the most useful. However the initial methionine cannot always be disambiguated, a problem not restricted to opsins. In run-on genes lacking 3' transcripts, the stop codon is taken as the first encountered in extending the last homologically reliable exon; however the true stop codon could lie in a different reading frame (ie in a cryptic terminal exon).
0 MDGNSTTPGIAVNLTVMPTIFPRSGYSILSFLMFLNAVFSICNNAIVILVTLKHPQLRNPINIFILNLSFSDLMMALCGTTIVVSTNYHGYFYLGKQFCIFQGFAVNYF 1
2 GIVSLWSLTLLAYERYNVVCEPIGALKLSTKRGYQGLVFIWLFCLFWAIAPLFGWSSYGPEGVQTSCSIGWEERSWSNYSYIISYFLTCFIIPVGIIGFSYGSILRSLHQ 0
0 LNRKIEQQGGKTNPREEKRVVIMVLFMVLAFLICWLPYTVFALIVVINPQLYISPLAATLPTYFAKTSPVYNPIIYIFLNKQ 0
0 FRTYAVQCLTCGHINLDSLEEDTESVSAQAENMLTPKTNQVAPA* 0


>ENCEPH_braBel Branchiostoma belcheri Amphiop5 early dup of ENCEPH extra Nfrag in mrna
Fragmentary genes are included if the species occupies a critical position in the phylogenetic tree (eg lamprey) and the fragment is long enough to reliably classify it. Fragmentary data often takes the form of entire exons missing from genomic coverage (rather than incomplete exons). When these exons lie in unconnected contigs, their combination into a single gene is not entirely reliable.
0 MLGIYNVVNATEYGNNTTFAAWDFKRNGTGGEEEVEFFGYDAVAGVIAIIGVVGFVSNGAVVVLFLKFPQLRTPFNLLLLNMAVADLLVSVCGNTLSFASAVRHRWLWGRPGCVWYGFANHLF 1
2 GLVSLISLAVISFLRYRMVVKPKGPGSSYLTYTKVGLAILFIYLYCLLWTTLPIAGWSSYQLEGPKIGCSVAWEEHSWSNTSYIVVLFITCLFAPLLIIVYSYYRLWHKVKQ 0
0 GSRNLPAAMRKSSQKEQKIAMMVIVMITCFMVCWLPYGAMALVVTFGGERLISHTAAVVPSLLAKSSTCYNPVVYFAMNSQ 0
0 FRRYFQDLLCCGRRLFDVSQSVVTGNTAMPRNNSQGFRKDDSDQKQDNGLPKQSEGPMCDHSSNESQMEGSRHNTAASQQWIEMQTIAVVVKAVEVDTSAANEP* 0


>ENCEPH_homSap encephalopsin OPN3 panopsin encephalopsin 1q43 - 47250 4 chr1:239,823,075-239,870,324 402 cone opsin with intron loss
For example the Callorhinchus genome project, currently with 0.6 exon coverage, still suffices to establish that many gene duplications important to vertebrate photoreceptive diversity had already occurred by the chondrichthyian divergence node. However without transcripts, a lineage-specific duplication in LWS might have result in a single chimeric gene assembled from scattered individual LWS exons.
0 MYSGNRSGGHGYWDGGGAAGAEGPAPAGTLSPAPLFSPGTYERLALLLGSIGLLGVGNNLLVLVLYYKFQRLRTPTHLLLVNISLSDLLVSLFGVTFTFVSCLRNGWVWDTVGCVWDGFSGSLF 1
2 GIVSIATLTVLAYERYIRVVHARVINFSWAWRAITYIWLYSLAWAGAPLLGWNRYILDVHGLGCTVDWKSKDANDSSFVLFLFLGCLVVPLGVIAHCYGHILYSIRM 0
0 LRCVEDLQTIQVIKILKYEKKLAKMCFLMIFTFLVCWMPYIVICFLVVNGHGHLVTPTISIVSYLFAKSNTVYNPVIYVFMIRK 0
0 FRRSLLQLLCLRLLRCQRPAKDLPAAGSEMQIRPIVMSQKDGDRPKKKVTFNSSSIIFIITSDESLSVDDSDKTNGSKVDVIQVRPL* 0


>ENCEPH_monDom encephalopsin_Monodelphis domestica 82% funny business with extra intron, alt splicing
Fragmentary genes for isolated fast-evolving invertebrates are difficult to distinguish from non-opsin GPCR which share many motifs such as DRY. To balance the need for maximal phylogenetic coverage against the imperative of not contaminating the opsin reference collection with non-opsin GPCR, partial genes are required to contain the K296 Schiff base and other diagnostic residues and motifs specific to opsins.
0 MYSDNSSDDGGGGYWGSGRAGGASGTGVTGEPGPEGSPRQAPLFSPGTYELLALLIATIGLLGLCNNLLVLVLYYKFQRLRTPTHLFLVNISFNDLLVSLFGVTFTFVSCLRSGWVWDSVGCAWDGFSNTLF 1
<font color ="blue">>RHO1_bosTau Bos taurus (cow) Deut.Euth.Laur NM_001014890 2145276 full Gt RH1 RHO rhodopsin rod opsin syn(-MBD4 +IFT122 +H1FOO -PLXND1)
2 GIVSIMTLTVLAYERYNRIVHAKVINFSWAWRAITYIWLYSLVWTGAPLLGWNRYTLEIHGLGCSVDWKSKDPNDSSFVIFLFFGCLMLPVGVMAYCYGHILYAIRM
0 MNGTEGPNFYVPFSNKTGVVRSPFEAPQYYLAEPWQFSMLAAYMFLLIMLGFPINFLTLYVTVQHKKLRTPLNYILLNLAVADLFMVFGGFTTTLYTSLHGYFVFGPTGCNLEGFFATLG 1
0 LRCVEELQTIQVIKILRYEKKVAKMCFLMIAIFLFCWMPYAVICLLVANGYGSLVTPTVAIIASLFAKSSTAYNPIIYIFMSRK 0
2 GEIALWSLVVLAIERYVVVCKPMSNFRFGENHAIMGVAFTWVMALACAAPPLVGWSR 2
0 FRRCLLQLLCFRLLKFQQPKKDRPVIRTEKQIRPIVMSQKVGDRPKKKVTFSSSSIIFIITSDETQMIDENDKNSGTKVNVIQVRPL* 0
1 YIPEGMQCSCGIDYYTPHEETNNESFVIYMFVVHFIIPLIVIFFCYGQLVFTVKE 0
 
0 AAAQQQESATTQKAEKEVTRMVIIMVIAFLICWLPYAGVAFYIFTHQGSDFGPIFMTIPAFFAKTSAVYNPVIYIMMNKQ 0
>ENCEPH_galGal new
0 FRNCMVTTLCCGKNPLGDDEASTTVSKTETSQVAPA* 0
0 MHSGNGTGATSRPQLAAAGHEVPGERPLFSAGTYELLALLIATIGTLGVCNNLLVLVLYYKFKRLRTPTNLFLVNISLSDLLVSVCGVSLTFMSCLRSRWVWDAAGCVWDGFSNSLF 1
2 GIVSIMTLTVLAYERYIRVVHAKVIDFSWSWRAITYIWLYSLAWTGAPLLGWNRYTLEIHGLGCSMDWKSKDPNDTSFVLLFFLGCLVAPVVIMAYCYGHILYAVRM 0
>RHO1_homSap Homo sapiens (human) Deut.Euth.Euar NM_000539 16565402 full Gt RH1 RHO rhodopsin rod opsin syn(-MBD4 +IFT122 +H1FOO -PLXND1)
0 LRCVEDFQTSQVIKLLKYEKKVAKMCFLMISTFLICWMPYAVVSLLVTYGYSNLVTPTVAIIPSFFAKSSTAYNPVIYIFMSRK 0
0 MNGTEGPNFYVPFSNATGVVRSPFEYPQYYLAEPWQFSMLAAYMFLLIVLGFPINFLTLYVTVQHKKLRTPLNYILLNLAVADLFMVLGGFTSTLYTSLHGYFVFGPTGCNLEGFFATLG 1
0 FRQCLLQLLCFRLMRFQRIMKEPSGAGNVKPIRPIVMSQKVGDRPKKKVTFSSSSIIFIIASDDTQQIDDNSKHNGTKVNVIQVKPL* 0
2 GEIALWSLVVLAIERYVVVCKPMSNFRFGENHAIMGVAFTWVMALACAAPPLAGWSR 2
 
1 YIPEGLQCSCGIDYYTLKPEVNNESFVIYMFVVHFTIPMIIIFFCYGQLVFTVKE 0
>ENCEPH_anoCar new
0 AAAQQQESATTQKAEKEVTRMVIIMVIAFLICWVPYASVAFYIFTHQGSNFGPIFMTIPAFFAKSAAIYNPVIYIMMNKQ 0
0 MFSANGTRSGAGSDLEPGPGQQQQQREASEEEERGAGLSPFSAGTYELLALLVAAIGLLGLCNNLLVLVLYAKFKRLRTPTHLFLVNISLSDLLVSLFGVSFTFGSCLRHRWVWDAAGCVWDGFSNSLF 1
0 FRNCMLTTICCGKNPLGDDEASATVSKTETSQVAPA* 0
2 GIVSIMTLTVLAYERYIRVVHARVIDFSWSWRAITYIWLYSLAWTGAPLLGWNHYTLEIHGLGCSVDWQSKEPSDSSFVLFFFLGCLAAPVGIMAYCYGHILHAIRM 0
0 LRCVEDLQSIQVIKILRYEKKVAKMCFLMVTTFLICWMPYAVVSLLIAYGYGHLITPTVAIIPSFFAKSSTAYNPVIYIFMSRK 0
>RHO1_monDom Monodelphis domesticus (opossum) Deut.Meta.Dide genomic full Gt RH1 RHO rhodopsin rod opsin syn(-MBD4 +IFT122 +H1FOO -PLXND1)
0 FRRCLVQLFCVQFLRFKRTLKEQPAIESNKPIRPIVMSQKVGDRPKKKVTFSSSSIIFIITSDDTEQIDVSTKCSDTKINVIQVKPL* 0
0 MNGTEGPNFYVPFSNKTGTVRSPFEEPQYYLADPWQFSCLAAYMFMLIVLGFPINFLTLYVTIQHKKLRTPLNYILLNLAIADLFMVFGGFTMTLYTSLHGYFVFGPTGCNLEGFFATLG 1
 
2 GEIALWSLVVLAIERYVVVCKPMSNFRFGENHAIIGVAFTWVMALACAFPPLIGWSR 2
>ENCEPH_xenTro new called TMT opsin in fish
1 YIPEGMQCSCGIDYYTLKPEVNNESFVIYMFVVHFTIPLIVIFFCYGQLVFTVKE 0
0 MPVTNGSHNNSISWLHSKDMFTEDTYHFLALIVATVGFLGLVNNLLVLILYCKFKRLQTPTNLLFFNTSLCHFVFSLLAITFTFMSCVRGSWAFSVEMCVFHGFSKNLL 1
0 AAAQQQESATTQKAEKEVTRMVIIMVIAFLICWLPYAGVAFYIFTHQGSNFGPIFMTIPAFFAKSSSVYNPVIYIMMNKQ 0
2 GIVSFGTLTVVAYERYARVVYGKYVNSSWSKRSITFVWVYSLAWTGFPLIGWNLYTFETHKLDCSFEWTATDPKDTAFVLLFFLACITLPLSIMAYCYGYILYEIQK 0
0 FRTCMITTLCCGKNPLGDDEASATASKTETSQVAPA* 0
0 LRSVKNIQNFQEITILDYEIKMAKMCLLMMLTFLIGWMPYTILSLLVTSGYSKFITPTITVMPSLLAIASAAYNPVIHIFTIKK 0
0 FRQCLVQLLPPINFHPPINPPINNFWRLLKNLNGRLAMKKVKPVLGKGRSHNRPEKKVPPINFSSSDFFTRTTSDTGTHGITESTKGKRTNVRLIQVHPL* 0
>RHO1_ornAna Ornithorhynchus anatinus (platypus) Deut.Prot.Mono ABN43074 17339011 full Gt RH1 RHO rhodopsin rod opsin syn(+IFT122 - -PLXND1)
 
0 MNGTEGQDFYIPMSNKTGVVRSPFEYPQYYLAEPWQYSVLAAYMFMLIMLGFPINFLTLYVTIQHKKLRTPLNYILLNLAFANHFMVLGGFTTTLYTSLHGYFVFGPTGCNIEGFFATLG 1
>ENCEPH_braBel Branchiostoma belcheri Amphiop4 pinopsin encephalopsin introns from braFlo 83%
2 GEIALWSLVVLAIERYIVVCKPMSNFRFGENHAIMGVAFTWIMALACALPPLVGWSR 2
0 MPLYNTSSGPTQGLPWDTPYSQDPIWNDSSPSNSSEDAVVDQGRGELQDFSDAGYTAIATGLALI 12 GLVGSMNNFVVILLIGCHRQLRTPFNLLLLNVSVADLLVSVCGNTLSFASAVQHRWLWGRPGCVWYGFANSLF 1
1 YIPEGMQCSCGIDYYTLRPEVNNESFVIYMFVVHFTIPMTIIFFCYGRLVFTVKE 0
2 GIVSLVTLSALAFERYCVVVRSSEMLTYKSSLGMIAFIWMYSLLWTSLPLLGWSSYQFEGHS 00 VGCSVNWVKHNVNNVSYIITLMVTCFFVPMVVVCWSYACIWRTVRM 0
0 AAAQQQESATTQKAEKEVTRMVIIMVIAFLICWVPYASVAFYIFTHQGSNFGPIFMTVPAFFAKSSAIYNPVIYIMMNKQ 0
0 SAEMKSEFGNPQNTGRLVTTMVVVMIVCFLVCWTPYTVMALIVTFGADHLVTPTASVIPSLVAKSSTAYNPIIYVLMNNQ 0
0 FRNCMLTTICCGKNPLGDDEASATASKTEQSSVSTSQVSPA* 0
0 FREFLLARLRTFCCRQPRMLRVTPMDDNAHARLVGEGPSHAQQVIPSEENGENVEMRKVQGNQLKADSLSTISE* 0
 
>RHO1_galGal Gallus gallus (chicken) Deut.Saur.Arch NM_205490 1385866 full Gt RH1 RHO rhodopsin rod syn(--MBD4 syn(+IFT122 +H1FOO -PLXND1)
>ENCEPH_braFlo blat from Amphiop4 Un - 207841137 207851157  10021 new exon12 and 34 + perfect fit 43% galGal 41% homSap
0 MNGTEGQDFYVPMSNKTGVVRSPFEYPQYYLAEPWKFSALAAYMFMLILLGFPVNFLTLYVTIQHKKLRTPLNYILLNLVVADLFMVFGGFTTTMYTSMNGYFVFGVTGCYIEGFFATLG 1
0 MALYNNTSSPSQDLLWDAPYSQGHIWDNSSASNSSEDVMDQGKVELQDFSDAGYTAIATCLALI 12 GFVGFTNNFVVILLIGCHRQLRTPFNLLLLNMSVADLLVSVCGNTLSFASAVRHRWLWGRPGCVWYGFANSLF 1
2 GEIALWSLVVLAVERYVVVCKPMSNFRFGENHAIMGVAFSWIMAMACAAPPLFGWSR 2
2 GIVSLVTLSALAFERYCVVVRSSDMLTYKSSLVVITFIWLYSLLWTSLPLLGWSSYQFEGHN 00 VGCSVNWVQHNPDNVSYIVTLMVTCFFVPMVVVCWSYAWIWRTVRM 0
1 YIPEGMQCSCGIDYYTLKPEINNESFVIYMFVVHFMIPLAVIFFCYGNLVCTVKE 0
0 SSEAKPECGNSQNAGRLVTTMVVVMIICFLVCWTPYAVMALIVTFGADHLVTPTASVIPSLVAKSSTAYNPIIYVLMNNQ 0
0 AAAQQQESATTQKAEKEVTRMVIIMVIAFLICWVPYASVAFYIFTNQGSDFGPIFMTIPAFFAKSSAIYNPVIYIVMNKQ 0
0 FREFLLARLQRVCCRQQAVPRVTPMDDNVHVRLGGEGPSQSQQFLPAGENVENVDMLEYVQENCKPKADSLSTISE* 0
0 FRNCMITTLCCGKNPLGDEDTSAGKTETSSVSTSQVSPA* 0
 
>ENCEPH2_Apis melifera length=321
>RHO1_anoCar Anolis carolinensis (lizard) Deut.Saur.Lepi genomic full Gt RH1 RHO rhodopsin rod opsin syn(-MBD4 +IFT122 - -PLXND1)
0 MEHVIYEDQVSPVMYIGAAIALGFIGFFGFTANLLVAIVIVKDAQILWTPVNVILFNLV 0
0 MNGTEGQNFYVPMSNKTGVVRNPFEYPQYYLADPWQFSALAAYMFLLILLGFPINFLTLFVTIQHKKLRTPLNYILLNLAVANLFMVLMGFTTTMYTSMNGYFIFGTVGCNIEGFFATLG 1
0 FGDFLVSIFGNPVAMVSAATGGWYWGYKMCLW 2
2 GEMGLWSLVVLAVERYVVICKPMSNFRFGETHALIGVSCTWIMALACAGPPLLGWSR 2
1 YAWFMSTLGFASIGNLTVMAVERWLLVARPMQALSIR 2
1 YIPEGMQCSCGVDYYTPTPEVHNESFVIYMFLVHFVTPLTIIFFCYGRLVCTVKA 0
1 HAVILASFVWIYALSLSLPPLFGWGSYGPEAGNVSCSVSWEVHDPVTNSDTYIGFLFVLGLIVPVFTIVSSYAAIVLTLKKVRKRA 1
0 AAAQQQESATTQKAEREVTRMVVIMVISFLVCWVPYASVAFYIFTHQGSDFGPVFMTIPAFFAKSSAIYNPVIYILMNKQ 0
2 GASGRREAKITKMVALMITAFLLAWSPYAALAIAAQYFN 0
0 FRNCMIMTLCCGKNPLGDEDTSAGTKTETSTVSTSQVSPA* 0
0 AKPSATVAVLPALLAKSSICYNPIIYAGLNNQFSRFLKKIFDARGSRTAVPDSQHTALTALNRQEQRK* 0
 
>RHO1_xenTro Xenopus tropicalis (frog) Deut.Amph.Anur genomic full Gt RH1 RHO rhodopsin rod opsin syn(-MBD4 +IFT122 - -PLXND1)
>ENCEPH1_Anopheles gambiae XM_312503 GPROP11 adjacent head-to-head tandem GPROP12
0 MNGTEGPNFYIPMSNKTGVVRSPFDYPQYYLAEPWKYSALAAYMFLLILLGFPINFMTLYVTIQHKKLRTPLNYILLNLVFANHFMVLCGFTVTMYTSMHGYFIFGQTGCYIEGFFATLG 1
0 MYDVTDAAAINSDHQELMAPWAYNGAAVTLFFIGFFGFFLNIFVIALMYKDVQ 0
2 GEMALWSLVVLAIERYVVVCKPMANFRFGENHAIMGVVFTWIMALSCAAPPLFGWSR 2
0 LWTPMNIILFNLVCSDFSVSIIGNPLTLTSAISHRWLYGKSICVAYGFFMSLL 1
1 YIPEGMQCSCGVDYYTLKPEVNNESFVVYMFIVHFTIPLCVIFFCYGRLLCTVKE 0
2 GIASITTLTVLSYERFCLISRPFAAQNRSKQGACLAVLFIWSYSFALTSPPLFGWGAYVNEAANI 1
0 AAAQQQESATTQKAEKEVTRMVVMMVIFFLICWVPYAYVAFYIFTHQGSDFGPVFMTVPAFFAKSSAIYNPVIYIVLNKQ 0
2 SCSVNWESQTANATSYIIFLFIFGLILPLAVIIYSYINIVLEMRK 0
0 FRNCLITTLCCGKNPFGDEEGSSAASSKTEASSVSSSQVSPA* 0
0 NSARVGRVNRAERRVTSMVAVMIVAFMVAWTPYAIFALIEQFGPPELIGPGLAVLPALVAKSSICYNPIIYVGMNTQ FRAAFWRIRRSNGVAGQPDSNNTNNSNRDKESARHTAKEGL
ECSLDFCHWTVRGTRVSISSAERNVPAPAARERSGGHSVTGSREESRDRHVTLKTMLSVGPRSPSSVAPVAADCSTTDVPTSGDGSVRIVRQDSELSVIHDGGGGGGGSSSRVLVIKSQKPRSNML* 0
>RHO1_neoFor Neoceratodus forsteri (lungfish) Deut.Sarc.Dipn EF526299 17961206 full Gt RH1 RHO rhodopsin rod opsin
 
0 MNGTEGPNFYVPMTNKTGVVRSPFEYPQYYLADPWKYSALAAYMFFLILTGFPINFLTLYVTVQHKKLRTPLNYILLNLAVADLFMVFGGFTTTMYTAMNGYFVFGVVGCNLEGFFATFG 1
>ENCEPH2_Anopheles gambiae XM_312502 GPROP12
2 GIIALWCLVVLAIERYIVVCKPISNFRFGENHAIMGVVFTWIMALACAGPPLFGWSR 2
0 MNDAPNDVAASAVDYEDLMAPWAYNASAVTLFFIGFFGFFLNLFVIALMCKDMQ 0
1 YIPEGMQCSCGIDYYTLKPEVNNESFVIYMFIVHFTIPLIIIFFCYGRLMCTVKE 0
0 LWTPMNIILFNLVCSDFSVSIIGNPLTLTSAISHRWIFGRTLCVAYGFFMSLL 1
0 AAAQQQESATTQKAEKEVTRMVYIMVISYLVCWLPYASVSFYIFTHQGSDFGPVFMTVPAFFAKTASVYNPVIYILMNKQ 0
2 GITSITTLTVLSYERYCLISRPFSSRNLTRRGAFLAIFFIWGYSFALTSPPLFGWGAYVQEAANI 1
0 FRNCMITTLCCGKNPFGDEETTSAGTSKTEASSVSSSQVSPA* 0
2 SCSVNWESQTKNATTYIIFLFVFGLVVPLIVIVYSYTNIIVNMRE 0
0 NSARVGRINRAEQRVTSMVAVMIVAFMVAWTPYAIFALIEQFGPPELIGPGLAVLPALVAKSSICYNPIIYVGMNTQ FRAAFSRVRNKGQQAAADQNTTTMQRELTKSSRDMVECSF
>RHO1_latCha Latimeria chalumnae (coelacanth) Deut.Sarc.Coel AAD30519 10339578 full Gt RH1 RHO rhodopsin rod opsin
DFCRKKSRFKISLVKPTAPLAVVDVSSTSHRDKGTSRSPLDQTVLNETNEDVGRERSGGGGGGGAYAGTRFVRPDFELSVINSGKSILIKSKNFRSNLL* 0
0 MNGTEGPNFYVPMSNKTGVVRNPFEYPQYYLADPWKYSALAAYMFFLILVGFPINFLTLFVTIQHKKLRTPLNYILLDLAVADLCMVFGGFFVTMYSSMNGYFVLGPTGCNIEGFFATLG 1
 
2 GQVALWALVVLAIERYVVVCKPMSNFRFGENHAIMGVIFTWIMALSCAVPPLFGWSR 2
>CILL2_Platynereis dumerilii emb|CT030681 htgs 171779 bp new CILL1 ENCEPH PARIE 44% e-65 393 5 exons 1 missing
1 YIPEGMQSSCGVDYYTLKPEVNNESFVIYMFVVHFTIPLIVIFFCYGRLVCTVKD 0
0 MDDLGFLGNSSVNYTVPLLQEDPLLLRILYFGPTSYVITAIYLCIVGVIGTLSNGVIMYLYFKDKSLRSPMNLLFVNLAMSDFTVAFFGAMFQFGLTCTRKYMSPGMALCDFYGFITFLG 1
0 AAAQQQESATTQKAEKEVTRMVIVMVISFLVCWVPYASVAAYIFFNQGSEFGPVFMTAPSFFAKSASFYNPVIYILLNKQ 0
2 GLASEMNLFIISVERYLAVVRPFDVGNLTNRRVIAGG 1
  0 FRNCMITTLCCGKNPFGDEDATSAAGSSKTEASSVSSSSVSPA* 0
2 VFVWLYSLVFAGGPLVGWSSYRPEGLGTWCSISWQDRSMNTMSYVTAVFLGCYFFPVSIIIFCYFNVWRKVKE 0
0 AADAQGAGTAGKAEKSIFRMSVIMVTCYLTAWTPYAIVCLIASYGPPNGLPIYAEVLPSLFAKSSQVYNPIIYVLMNKP 0
>RHO1_angAng Anguilla anguilla (european_eel) Deut.Acti.Elop L78008 full Gt RH1 RHO rhodopsin rod opsin
0 0* 0
0 MNGTEGPNFYIPMSNITGVVRSPFEYPQYYLAEPWAYTILAAYMFTLILLGFPVNFLTLYVTIEHKKLRTPLNYILLNLAVANLFMVFGGFTTTVYTSMHGYFVFGETGCNLEGYFATLG 1
 
2 GEISLWSLVVLAIERWVVVCKPMSNFRFGENHAIMGLAFTWIMANSCAMPPLFGWSR 2
>CILL1_Platynereis dumerilii lophotrochozoa ciliary opsin mRNA polychaeta unavailable genomically
1 YIPEGMQCSCGVDYYTLKPEVNNESFVIYMFIVHFSVPLTIISFCYGRLVCTVKE 0
0 MDGENLTIPNPVTELMDTPINSTYFQNLNAETDGGNHYIYNAFTATDYNICAAYLFFIACLGVSLNVLVLVLFIKDRKLRSPNNFLYVSLALGDLLVAVFGTAFKFIITARKTLLREEDGFCKWYGFITYLG 1
0 AAAQQQESETTQRAEREVTRMVVIMVIAFLVCWVPYASVAWYIFTHQGSTFGPVFMTVPSFFAKSSAIYNPLIYICLNSQ 0
2 GLAALMTLSVIAFVRCLAVLRLGSFTGLTTRMGVAAMA 1
0 FRNCMITTLFCGKNPFQEEEGASTTASKTEASSVSSVSPA* 0
2 FIWIYSLAFTLAPLLGWNHYIPEGLATWCSIDWLSDETSDKSYVFAIFIFCFLVPVLIIVVSYGLIYDKVRK 0
0 VAKTGGSVAKAEREVLRMTLLMVSLFMLAWSPYAVICMLASFGPKDLLHPVATVIPAMFAKSSTMYNPLIYVFMNKQ 0
>RHO1_conMyr Conger myriaster (conger_eel) Deut.Acti.Elop AB043817 full Gt RH1 RHO rhodopsin rod opsin
0 FRRSLKVLLGMGVEDLNSESERATGGTATNQVAAT*
0 MNGTEGPNFYIPMSNATGVVRSPFEYPQYYLAEPWAFSALSAYMFFLIIAGFPINFLTLYVTIEHKKLRTPLNYILLNLAVADLFMVFGGFTTTMYTSMHGYFVFGPTGCNIEGFFATLG 1
 
2 GEIALWCLVVLAIERWMVVCKPVTNFRFGESHAIMGVMVTWTMALACALPPLFGWSR 2
 
1 YIPEGLQCSCGIDYYTRAPGINNESFVIYMFTCHFSIPLAVISFCYGRLVCTVKE 0
>RGR_homSap 10q23.1 + 14136 7 chr10:85,994,789-86,008,924 295 exons distinct retinal pigment epithelium and Mueller cells
0 AAAQQQESETTQRAEREVTRMVVIMVISFLVCWVPYASVAWYIFTHQGSTFGPIFMTIPSFFAKSSALYNPMIYICMNKQ 0
0 MAETSALPTGFGELEVLAVGMVLLVE 1
0 FRHCMITTLCCGKNPFEEEDGASATSSKTEASSVSSSSVSPA* 0
2 ALSGLSLNTLTIFSFCKTPELRTPCHLLVLSLALADSGISLNALVAATSSLLR 2
1 VSHRRWPYGSDGCQAHGFQGFVTALASICSSAAIAWGRYHHYCT 1
>RHO1_danRer Danio rerio (zebrafish) Deut.Acti.Otoc NM_131212 18597743 full Gt RH1 RHO rhodopsin rod opsin extra-ocular rhodopsin
2 RSQLAWNSAVSLVLFVWLSSAFWAALPLLGWGHYDYEPLGTCCTLDYSKGDR 2
0 MNGTEGPNFYVPMSNRTGLVRSPFEEPQYYLAEPWQFSLLAAYMLFLILGSFPINALTLYVTVQHKKLRTPLNYILLNLAVADLFMVLGGFTVTLYTALHGYFLLGVTGCNIEGFFATLG 1
1 NFTSFLFTMSFFNFAMPLFITITSYSLMEQKLGKSGHLQ 0
2 GEIALWSLVVLAIERYIVVCKPMSTFRFGEKHAIIGVGFTWVMALTCAVPPLLGWSR 2
0 VNTTLPARTLLLGWGPYAILYLYAVIADVTSISPKLQM 0
1 YIPEGMQCSCGIDYYTPKPEVHNTSFVIYMFILHFSIPLLIIFFCYSRLLCTVRA 0
0 VPALIAKMVPTINAINYALGNEMVCRGIWQCLSPQKREKDRTK* 0
0 AAAQQQESETTQRAEREVTRMVVVMVIAFLVCWVPYASVAWYIFANQGAEFGPVFMTVPAFFAKSAALYNPVIYIMLNRQ 0
 
0 FRNCMLSTVCCGKNPLAEDESSSAVSSKTQSSVVSSAQVSPA* 0
>PER_homSap peropsin RRH 4q25 7 chr4:110,968,599-110,985,310 337 + 16712 retinal photoisomerase Retinal pigment epithelium
0 MLRNNLGNSSDSKNEDGSVFSQTEHNIVATYLIMA 1
>RHO1_tetNig Tetraodon nigroviridis (pufferfish) Deut.Acti.Perc genomic full G? RH1 RHO rhodopsin rod opsin
2 GMISIISNIIVLGIFIKYKELRTPTNAIIINLAVTDIGVSSIGYPMSAASDLYGSWKFGYAGCQ 0
0 MNGTEGPNFYVPMSNKTGVVRSPFEYPQYYLAEPWKYSLVAAYMLFLIVTAFPVNFLTLFVTVKHKKLRTPLNYVLLNLAVADLFMVIGGFTVTLYTALHAYFVLGVTGCNIEGFFATLG 1
0 VYAGLNIFFGMASIGLLTVVAVDRYLTICLPDV 1
2 GEIALWSLVVLAIERYIVVCKPVTNFRFGEKHAIAGLAFTWIMALSCAVPPLLGWSR 2
2 GRRMTTNTYIGLILGAWINGLFWALMPIIGWASYAPDPTGATCTINWRKNDR 2
1 YIPEGMQCSCGIDYYTPKPEIHNTSFVIYMFVLHFCIPLAIIFFCYSRLLCTVRA 0
1 SFVSYTMTVIAINFIVPLTVMFYCYYHVTLSIKHHTTSDCTESLNRDWSDQIDVTK 0
0 AAALQQESETTQRAEKEVTRMVIVMVISFLVCWVPYASVAWYIFANQGTEFGPVFMTAPAFFAKSAALYNPVIYILLNRQ 0
0 MSVIMICMFLVAWSPYSIVCLWASFGDPKKIPPPMAIIAPLFAKSSTFYNPCIYVVANKK 2
0 FRNCMITTVCCGKNPFGDDDATTSVSKTQSSSVSTSQVAPA* 0
1 FRRAMLAMFKCQTHQTMPVTSILPMDVSQNPLASGRI* 0
 
>RHO1_takRub Takifugu rubripes (fugu) Deut.Acti.Perc AF201472 10692583 full Gt RH1 RHO rhodopsin rod opsin syn(-MBD4 +IFT122 - -PLXND1)
>PERa_Branchiostoma belcheri Amphiop3 peropsin
0 MNGTEGPNFYIPMSNKTGVVRSPFEYPQYYLAEPWKYSLVAAYMLFLIITAFPVNFLTLFVTVKHKKLRTPLNYVLLNLAVADLFMVIGGFTVTLYTALHAYFVLGVTGCNIEGFFATLG 1
MDIPTETPYGAEEDIGESAGWRWTETDKNGFHKYDHLIVGLYLFVIGIIGTIENGITLATFSKFRSLRSPTTMLLVHLAI
2 GEIALWSLVVLAVERYIVVCKPMTNFRFGEKHAIAGLVFTWIMALTCATPPLLGWSR 2
ADLGICIFGYPFSGASSLRSHWLFGGVGCQWYGFNGMFFGMANIGLLTCVAVDRYLVICRHDLVDKVNYNTYGVMAALGW
1 YIPEGMQCSCGIDYYTPKPEINNTSFVIYMFILHFSIPLAIIFFCYSRLLCTVRA 0
LFAAFWAALPLVGWAEYALEPSGTACTINFQKNDSLYISYVTSCFVLGFVVPLAVMAFCYWQASCFVSKVLKGDIAGDLT
0 AAALQQESETTQRAEKEVTRMVIVMVISFLVCWVPYASVAWYIFANQGTEFGPVFMTAPAFFAKSAALYNPVIYILLNRQ 0
FPVAANVDWEYQNHFSKMCLAMVAAFVVAWTPYSVLFLFAAFWNPADIPAWLTLLPPLIAKSSALYNPIIYIIANRR FRNAICSMMKGQDPDVEDDEHADEHRVRSIEDNDKEIISMVNLNMTV*
0 FRNCMITTVCCGKNPFGDDDAATTVSKTQSSSVSSSQVAPA* 0
 
>PERb_Branchiostoma belcheri Amphiop2 peropsin RRH
>RHO1_gasAcu Gasterosteus aculeatus (stickleback) Deut.Acti.Perc BT028623 full Gt RH1 RHO rhodopsin rod opsin
MIPTNNNTENNDLEWGLEKEHGVSATIMGVYLTIVGLVATVGNATVVLMFIMKWRQLCRKAPNLLVINLAAANLCITIFG
0 MNGTEGPYFYVPMMNTTGIVRSPYEYPQYYLVNPAAYAALGAYMFLLILVGFPVNFLTLYVTLEHKKLRTPLNYILLNLAVANLFMVLGGFTTTMYTSMHGYFVLGRLGCNVEGFFATLG 1
YPFSASSGYAHQWLFPDAICTLYGFSCFLLSMVSMHTLCLISAHRYITICRPEHASKLTMNRTVLAVIGTWLYAIAVAVP
2 GEIALWSLVVLAVERWVVVCKLIANFRFGEDHAIMGLALTWVMASACAVPPLVGWSR 2
PLFNIARYTYEPSGLSCTIDFRVTTVADLVYLGSLIVLCYVIHVAVMATCYFKIIRKFSRHRFRQVRDIRTSHQRSFEMG
1 YIPEGMQCSCGVDYYTRAEGFNNESFVIYMFVCHFMIPMIIIFFCYGRLLCAVKEA 0
VTMRCILMTLFYLLSWTPYTAVCIWTMVGPPPPVVVSMAAALIAKTHCAFNPILYAFMSEVYRKLVFRTMCPCCFNRISC
0 AAAQQESETTQRAEREVSRMVVIMVIAFLVCWVPYASVAWFIFCNQGSEFGPVFMTIPAFFAKSSSVYNPLIYICMNKQ 0
KFVGTPTGGSKVSANPDIFTVDYNSRDQAVQINKAPSRRFCFVMETSEDLGSDDTGLTGHSGLWRSGAEVEGLGGLQVTQ
0 FRHCMITTLCCGKNPFEEEEGASSTKTEASSVSTSSVSPA* 0
SPSVSGSELSLSLLDFLPPKPSGRAVSAKLPSPPALNSERATCPESSQQPSDRPATGLRQYQKGDTTRSSVGDLILTEDD
VTNLPPASETWGRKKSENPLSYRQTTRRTFGRSRKHSYIVD*
>RHO1_oryLat Oryzias latipes (medaka) Deut.Acti.Perc AB180742 15964232 full Gt RH1 RHO rhodopsin rod opsin
 
  0 MNGTEGPYFYVPMVNTTGIVRSPYEYPQYYLVNPAAYAALGAYMFFLILVGFPINFLTLYVTLEHKKLRTPLNYILLNLAVADLFMVFGGFTTTMYTSMHGYFVLGRLGCNLEGFFATLG 1
>PERc_Branchiostoma belcheri Amphiop1 peropsin RRH
2 GEIGLWSLVVLAIERWVVVCKPISNFRFGENHAIMGLVFTWIMAASCAVPPLVGWSR 2
MNASPSSWLSSGEFFTDSPENSSEWPWTDGPTDTTWRHHQSVDSVSYEGYLASAIYITLTGLIAFFGNVITITVFLTEKE
1 YIPEGMQCSCGVDYYTRAEGFNNESFVVYMFVCHFLIPLIVVFFCYGRLLCAVKEA 0
FRKKQQNGFVLNLAIADLSVCVFAYPSSAIAGYAGRWVLGDVGCTIYGFLCFTFALVSMVTLCVISIYRYILICKPQYAH
0 AAAQQESETTQRAEREVTRMVVIMVIGFLVCWLPYASVAWYIFTNQGSEFGPLFMTIPAFFAKSSSIYNPAIYICMNKQ 0
LLTHRRTVYVIIGTWLYALVFTVPPLVGVKRYTYEPMQITCSLDWNVQHPGEKAYIAAVLVIVYVLQVLIMCFCYFNIIF
0 FRNCMITTLCCGKNPFEEEEGASTTASKTEASSVSSSSVSPA* 0
KSANLKFAALASEKTKMAAKKDTWKTSVMCLTMVVSFLIAWTPYAVSSTWDILSAEDLPIIATILPSLFAKSSCMMNPII
YACCNTK FRQAAVKSFRKLCGMCKQKVPLSTPQVVLAMQRNTEFTSTVEPTGQAFPMRVLPSISATHTAL*
>RHO1_leuEri Leucoraja erinacea (skate) Deut.Chon.Elas U81514 9256070 full Gt RH1 RHO rhodopsin rod opsin
 
0 MNGTEGENFYVPMSNKTGVVRSPFDYPQYYLGEPWMFSALAAYMFFLILTGLPVNFLTLFVTIQHKKLRQPLNYILLNLAVSDLFMVFGGFTTTIITSMNGYFIFGPAGCNFEGFFATLG 1
>NEUR_homSap neuropsin 6p12.3 chr6:47,857,757-47,902,075 7 354
2 GEVGLWCLVVLAIERYMVVCKPMANFRFGSQHAIIGVVFTWIMALSCAGPPLVGWSR 2
0 MALNHTALPQDERLPHYLRDGDPFASKLSWEADLVAGFYLTII 1
1 YIPEGLQCSCGVDYYTMKPEVNNESFVIYMFVVHFTIPLIVIFFCYGRLVCTVKE 0
2 GILSTFGNGYVLYMSSRRKKKLRPAEIMTINLAVCDLGIS 1
0 AAAQQQESESTQRAEREVTRMVIIMVVAFLICWVPYASVAFYIFINQGCDFTPFFMTVPAFFAKSSAVYNPLIYILMNKQ 0
2 VVGKPFTIISCFCHRWVFGWIGCRWYGWAGFFFGCGSLITMTAVSLDRYLKICYLSY 1
0 FRNCMITTICLGKNPFEEEESTSASASKTEASSVSSSQVAPA* 0
2 GVWLKRKHAYICLAAIWAYASFWTTMPLVGLGDYVPEPFGTSCTLDWWLAQASVGGQVFILNILFFCLLLPTAVIVFSYVKIIAKVKSSSKEVAHFDSRIHSSHVLEMKLTK 0
0 VAMLICAGFLIAWIPYAVVSVWSAFGRPDSIPIQLSVVPTLLAKSAAMYNPIIYQVIDYK FACCQTGGLKATKKKSLEGFR 2
>RHO1_calMil Callorhinchus milii (elephantfish) Deut.Chon.Holo genomic full Gt RH1 RHO rhodopsin rod opsin
1 LHTVTTVRKSSAVLEIHEE 0
0 MNGTEGENFYIPMSNKTGVVRSPFEYPQYYLAEPWQFSILAAYMFFLIITCFPVNFLTLYVTFEHKKLRQPLNFILLNLAVADLFMVFGGFFITVYTSLHGYFVFGVTGCNFEGFFATLG 1
0 WE* 0
2 GEIGLWSLVVLAIERYVVVCKPMSNFRFGTNHAIMGVAFTWVMALACAVPPLMGWSR 2
 
1 YIPEGLQCSCGVDYYTLKPEINNESFVIYMFVVHFLIPLIIIFFCYGRLVCTVKE 0
>MEL1_homSap  melanopsin rhabdomeric OPN4 10q23.2 + 11903 10 chr10 GLUD1 MMRN2 BMPR1A LDB3 OPN4 WAPAL GRID1
0 AAAQQQESESTQRAEREVTRMVIIMVIFFLICWVPYASVAFFIFTNQGSEFGPIFMAVPAFFAKSSALYNPLIYILLNKQ 0
0 MNPPSGPRVPPSPTQEPSCMATPAPPSWWDSSQSSISSLGRLPSISPT 0
0 FRNCMITTLCCGKNPFEEDESTSAAASKTEASSVSSSQVSPA* 0
0 APGTWAAAWVPLPTVDVPDHAHYTLGTVILLVGLTGMLGNLTVIYTFCR 2
1 SRSLRTPANMFIINLAVSDFLMSFTQAPVFFTSSLYKQWLFGET 1
>RHO1_petMar Petromyzon marinus (lamprey) Deut.Agna.Hype genomic full Gt RH1 RHO rhodopsin rod opsin
2 GCEFYAFCGALFGISSMITLTAIALDRYLVITRPLATFGVASKRRAAFVLLGVWLYALAWSLPPFFGW 1
0 MNGTEGENFYIPFSNKTGLARSPFEYPQYYLAEPWKYSVLAAYMFFLILVGFPVNFLTLFVTVQHKKLRTPLNYILLNLAVANLFMVLFGFTLTMYSSMNGYFVFGPTMCNFEGFFATLG 1
2 SAYVPEGLLTSCSWDYMSFTPAVRAYTMLLCCFVFFLPLLIIIYCYIFIFRAIRETGR 2
2 GEMSLWSLVVLAIERYIVICKPMGNFRFGSTHAYMGVAFTWFMALSCAAPPLVGWSR 2
1 ALQTFGACKGNGESLWQRQRLQSECKMAKIMLLVILLFVLSWAPYSAVALVAFAG 2
1 YLPEGMQCSCGPDYYTLNPNFNNESFVIYMFLVHFIIPFIVIFFCYGRLLCTVKE 0
1 YAHVLTPYMSSVPAVIAKASAIHNPIIYAITHPKYR 2
0 AAAAQQESASTQKAEKEVTRMVVLMVIGFLVCWVPYASVAFYIFTHQGSDFGATFMTVPAFFAKTSALYNPIIYILMNKQ 0
1 VAIAQHLPCLGVLLGVSRRHSRPYPSYRSTHRSTLTSHTSNLSWISIRRRQESLGSESEV 0
0 FRNCMITTLCCGKNPLGDEDSGASTSKTEVSSVSTSQVSPA* 0
0 GWTHMEAAAVWGAAQQANGRSLYGQGLEDLEAKAPPRPQGHEAETPGK 0
0 TKGLIPSQDPRM* 0
>RHO1_geoAus Geotria australis (lamprey) Deut.Agna.Hype AY366493 17463225 full Gt RhA
 
0 MNGTEGQNFYIPFSNKTDVARSPFEYPQYYLAEPWKFSALAAYMFFLILVGFPVNFLTLFVTVQHKKLRTPLNYILLNLAVSNLFMILFGFTTTMYTSMNGYFVFGPTMCSIEGFFATLG 1
>MEL1_smiCra OPN4 Sminthopsis crassicaudata melanopsin (Opn4)
2 GEVSLWSLVVLAIERYIVICKPMGNFRFGNTHAIMGVALTWVMALSCAAPPLLGWSR 2
0 MNPSPMLRHLSCPAQDSNCTKIMASISEWNNTEVDAYHLVDLPPITPT 0
1 YLPEGMQCSCGPDYYTMNPTYNNESFVIYMFIVHFTIPFVIIFFSYGRLLCTVKE 0
0 AVVLPPYSQKVFPTADVPDYAHYTIGATILVVGFTGVLGNLLVIYTFCR 2
0 AAAAQQESASTQKAEKEVTRMVVLMVVGFLVCWVPYASVAFYIFTNQGSDFGATFMTLPAFFAKSSALYNPVIYILMNKQ 0
1 SRSLRTPANMFIINLAISDFFMSFTQAPVFFASSLYERWIFGEK 1
0 FRNCMITTLCCGKNPLGDDDSGASTSKTEVSSVSTSQVAPA* 0
2 GCEFYAFCGALFGITSMITLMVIALDRYFVITRPLASIGMISKKKTGLILLGVWLYSLAWSLPPFFGW 1
2 SAYVPEGLLTSCSWDYTTFTPSVRAYTILLFCFVFFIPLTVIIYCYIFIFRAIKDTNKAVQNIGSSE
>RHO1_letJap Lethenteron japonicum (lamprey) Deut.Agna.Hype AB116382 15096614 full Gt RH1 RHO rhodopsin rod opsin
HTPSLRHFQRMKNEWKMAKIALVVILLFVLSWAPYSTVALVAFAGYSHVLTPYMNSVP
0 MNGTEGDNFYVPFSNKTGLARSPYEYPQYYLAEPWKYSALAAYMFFLILVGFPVNFLTLFVTVQHKKLRTPLNYILLNLAMANLFMVLFGFTVTMYTSMNGYFVFGPTMCSIEGFFATLG 1
AIIAKASAIHNPIIYAISHPKYRMAIAQNFPCLRAVLGIRHPRTQSFSSYRFTHRSTT
2 GEVALWSLVVLAIERYIVICKPMGNFRFGNTHAIMGVAFTWIMALACAAPPLVGWSR 2
ASQASDISWQSRGRRQLSLGSESEAGWNNIETGLTLRSLEGSCGMDEETMDTRELSAS
1 YIPEGMQCSCGPDYYTLNPNFNNESYVVYMFVVHFLVPFVIIFFCYGRLLCTVKE 0
TKAKGQSWETLAKTLEEMDDLSLLEAGTLLSSLDLQI* 0
0 AAAAQQESASTQKAEKEVTRMVVLMVIGFLVCWVPYASVAFYIFTHQGSDFGATFMTLPAFFAKSSALYNPVIYILMNKQ 0
 
0 FRNCMITTLCCGKNPLGDDESGASTSKTEVSSVSTSQVSPA* 0
>MEL1_galGal OPN4 melanopsin1 genome screwed up
0 MDLPPRAPT 0
>RHO2_galGal Gallus gallus (chicken) Deut.Saur.Arch NP_990771 2268324 full Gt syn(-IHPK3 -LEMD2 +RHO2 -GRM4 -NUDT3)
0 KMTVKDVRGAFPTVDVPDHAHYTIGTVILIVGITGTLGNFLVIYAFCR 2
0 MNGTEGINFYVPMSNKTGVVRSPFEYPQYYLAEPWKYRLVCCYIFFLISTGLPINLLTLLVTFKHKKLRQPLNYILVNLAVADLFMACFGFTVTFYTAWNGYFVFGPVGCAVEGFFATLG 1
1 SRTLQKPANIFIINLAVSDFLMSITQSPVFFTNSLHKRWIFGEK 1
2 GQVALWSLVVLAIERYIVVCKPMGNFRFSATHAMMGIAFTWVMAFSCAAPPLFGWSR 2
2 GCELYAFCGALFGITSMITLMVIALDRYFVITKPLASVRVMSKKKALIILVGVWLYSLAWSLPPFFGW 1
1 YMPEGMQCSCGPDYYTHNPDYHNESYVLYMFVIHFIIPVVVIFFSYGRLICKVRE 0
2 SAYVPEGLLTSCSWDYMTFTPSVRAYTMLLFCFVFFIPLIAIIYSYVFIFEAIKKANK 2
0 AAAQQQESATTQKAEKEVTRMVILMVLGFMLAWTPYAVVAFWIFTNKGADFTATLMAVPAFFSKSSSLYNPIIYVLMNKQ 0
1 SVQTFGCKHGNRELQKQYHRMKNEWKLAKIALIVILLYVISWSPYSVVALVAFAG 2
0 FRNCMITTICCGKNPFGDEDVSSTVSQSKTEVSSVSSSQVSPA* 0
1 YSHVLTPFMNSVPAVIAKASAIHNPIIYAITHPKYR 2
1 TAIATYVPCLGFLLRVSPKESRSFSSYPSSRRTTITSQSSETSGLQKGKRRLSSISDSES 0
>RHO2_taeGut Taeniopygia guttata (finch) Deut.Saur.Arch NM_001076696 full G?
0 GCTDTETDITSMISRPASSQVSYEMGEDTTQTSDLGGKPKVKSHDSGIFRK 0
0 MNGTEGINFYVPMSNKTGVVRSPFEYPQYYLAEPWKYRLVCCYIFFLISTGFPINFLTLLVTFKHKKLRQPLNYILVNLAVADLCMACFGFTVTFYTAWNGYFVFGPIGCAVEGFFATLG 1
0 TVVDADEIPMVEINDTEHSATSTCKTSEKCNVEEIQ 0
2 GQVALWSLVVLAIERYIVICKPMGNFRFSASHALMGIAFTWVMAISCAAPPLFGWSR 2
0 RSESLSGIGLREGESRHRTSASQIPSIIITYSNVQGVELHSGYSAGFLHPKNKSHKQNKSSNS* 0
1 YIPEGMQCSCGPDYYTHNPDFHNESYVLYMFVIHFIIPVVIIFFSYGRLVCKVRE 0
 
0 AAAQQQESATTQKAEKEVTRMVILMVLGFMLAWTPYAVVAFWIFTNKGADFTATLMAVPAFFSKSSSLYNPIIYVLMNKQ 0
>MEL1_xenTro Xenopus tropicalis melanopsin approx
0 FRNCMITTICCGKNPFGDEETSSTVSQSKTEVSSVSSSQVSPA* 0
0 MNYQSVRKGITCPPQDANCSRILESLNSWNNSEVNSYKLVELPPIVTTETPQYEIHHVYPT 0
0 VDVPDHVHYVVGAVILAVGITGMLGNFLVIYAFCR 2
>RHO2_anoCar Anolis carolinensis (lizard) Deut.Saur.Lepi genomic full Gt syn(-IP6K3 -LEMD2 -MLN +RHO2 -GRM4 -NUDT3)
1 SRSLRSPANMFIINLAITDFLMSVTQAPVFFATSLHKRWIFGEK 1
0 MNGTEGINFYVPLSNKTGLVRSPFEYPQYYLAEPWKYKVVCCYIFFLIFTGLPINILTLLVTFKHKKLRQPLNYILVNLAVADLFMACFGFTVTFYTAWNGYFIFGPIGCAIEGFFATLG 1
2 GCELYAFCGALFGITSMITLMVIAVDRYFVITRPLTSIGVMSKKRAVLILSGVWLYSLAWSLPPFFGWS 1
2 GQVALWSLVVLAIERYIVVCKPMGNFRFSATHALMGISFTWFMSFSCAAPPLLGWSR 2
2 AYVPEGLLTSCTWDYMTFTPSVRAYTMLLFCFVFFIPLFIIIYCYIFIFKAIKNTNR 2
1 YIPEGMQCSCGPDYYTLNPDYHNESYVLYMFGVHFVIPVVVIFFSYGRLICKVRE 0
1 AVQKIGTDNNKESHKQYQKMKNEWKMAKIALIVILLYVVSWSPYSTVALLAFAG 2
0 AAAQQQESASTQKAEREVTRMVILMVLGFLLAWTPYAMVAFWIFTNKGVDFSATLMSVPAFFSKSSSLYNPIIYVLMNKQ 0
1 YASILTPYMNSVPAVIAKASAIHNPIIYAITHPKYR 2
0 FRNCMITTICCGKNPFGDEDVSSSVSQSKTEVSSVSSSQVSPA* 0
1 MAIAKYIPCLGSLLRVKRRDSRSYSSYPSSRRSTVTSHCSQSSDVGGHPKLKNHLPSVSDSES 0
0 GWTDTEADSSVNSRPASRQVSYEMGKDTTETNDLKSKAKLKSHDSGIFEKTSMDADD 0
>RHO2_gekGek Gekko gekko (gecko) Deut.Saur.Lepi AY024356 11591478 full Gt in pure rod retina
0 ISLVELGTVDRSSP...IMANKHLNGLGQRKGDSFTRRSPSSRIPSIVVTHSNHQGSPAAVRHNSTLPGIKVSNSQDREKELKRQIEKVKQYVPIVTITSDTENSTGGFSNELLPANTS* 0
0 MNGTEGINFYVPLSNKTGLVRSPFEYPQYYLADPWKFKVLSFYMFFLIAAGMPLNGLTLFVTFQHKKLRQPLNYILVNLAAANLVTVCCGFTVTFYASWYAYFVFGPIGCAIEGFFATIG 1
 
2 GQVALWSLVVLAIERYIVICKPMGNFRFSATHAIMGIAFTWFMALACAGPPLFGWSR 2
>MEL1a_Branchiostoma belcheri melanopsin
1 FIPEGMQCSCGPDYYTLNPDFHNESYVIYMFIVHFTVPMVVIFFSYGRLVCKVRE 0
MTEIPSFQPPINATEVEEENAVFPTALTEWFSEVGNQVGEVALKLLSGEGDGMEVTPTPGCTGNGSVCNGTDSGGVVWDI
0 AAAQQQESATTQKAEKEVTRMVILMVLGFLLAWTPYAATAIWIFTNRGAAFSVTFMTIPAFFSKSSSIYNPIIYVLLNKQ 0
PPLAHYIVGTAVFCIGCCGMFGNAVVVYSFIKSKGLRTPANFFIINLALSDFLMNLTNMPIFAVNSAFQRWLLSDFACEL
0 FRNCMVTTICCGKNPFGDEDVSSSVSQSKTEVSSVSSSQVAPA* 0
YGFAGGLFGCLSINTLMAISMDRYLVITKPFLVMRIVTKQRVMFAILLLWIWSLVWALPPLFGWSAYVSEGFGTSCTFDY
MTPKLSYHIFTYIIFFTMYFIPGGVMIYCYYNIFATVKSGDKQFGKAVKEMAHEDVKNKAQQERQRKNEIKTAKIAFIVI
>RHO2_podSic Podarcis sicula (lizard) Deut.Saur.Lepi AY941829 12887418 full G?
SLFMSAWTPYAVVSALGTLGYQDLVTPYLQSIPAMFAKSSAVYSPIVYAITYPKFREAVKKHIPCLSGCLPASEEETKTK
  0 MNGTEGINFYVPLSNKTGLVRSPFEYPQYYLAEPWKYKMVCCYIFFLISTGLPINLLTLLVTFKHKKLRQPLNYILVNLAVADLFMACFGFTVTFYTAWNGYFIFGPIGCAIEGFFATLG 1
TRGQSSASASMSMTQTTAPVHDPQASVDSGSSVSVDDSSGVSRQDTMMVKVEVDKRMEKAGGGAADAAPQEGASVSTVSA
  2 GQVALWSLVVLAIERYIVVCKPMGNFRFSSSHALMGIAFTWVMSLSCACPPLFGWSR 2
QIEVRPSGKVTTKADVISTPQTAHGLSASPVPKVAELGSSATLESAAIPGKIPTPLPSQPIAAPIERHMAAMADEPPPKP
  1 YIPEGMQCSCGPDYYTLNPDYHNESYVVYMFVIHFVIPVVVIFFSYGRLICKVRE 0
RGVATTVNVRRTESGYDRSQDSQRKKVVGDTHRSRSFNTTKDHFASEQPAALIQPKELYSDDTTKKMARQSSEKHEYDNP
0 AAAQQQESASTQKAEKEVTRMVILMVLGFMLAWTPYAVVAFWIFTNKGADFSATLMSVPAFFSKSSSLYNPIIYVLMNKQ 0
AFDEGITEVDTDSENETEGSYDMLSVRFQAMAEEPPVETYRKASDLAINLGKASLMLSEAHDETVL*
0 FRNCMITTICCGKNPFGDDDVSSTVSQSKTEVSSISSSQVSPA* 0
 
   
>MEL1b_Branchiostoma belcheri Amphiop6 melanopsin
>RHO2_pheMad Phelsuma madagascariensis (lizard) Deut.Saur.Lepi AF074044 10069370 full G?
MSSNLTNVSLVANRTDQTELSPTDVTMQLIFGSMMLVFGLIGVVGNVVALYAFCRTRSLRRPKNYVVANLCLTDMFVCLV
0 MNGTEGFNFYVPVSNRTGLVRSPYEYPQYYLAEPWKFKALSLYMFFLILVGLPLNGLTLFVTFQHKKLRQPLNYILVNLAVANLLMVICGFTVTFYTSWYGYFVFGPMGCAFEGFFATIG 1
YCPIVVSRSFSHGFPSKESCIVEGFMVGVGSIASICSLAAIAVERYLSVTQPLKSLTILTQRKLLVAVLTVWVYSLLLAF
2 GQVALWSLVVLAIERYIVICKPMGNFRFSSSHAMMGISFTWFMALCCGGPPLFGWSR 2
PPLVGWGRYVREETYISCTFDYLSTDDATRAYVITLVMGAFGFPLLTIAYCYIRVFTTARKHAEERKFMSPLKRPESRTE
1 FIPEGMQCSCGPDYYTLNPDFHNESYVIYLFTVHFLTPMIIIFFSYGRLVCKVRE 0
IKTAVTACVITTSFCLCWCPYAVVATLGISGVSVQQQTVFSAALLAKLTVIINPIVYVLSIPNFRKALFAQEREKYASED
0 AAAQQQESATTQKAEKEVTRMVILMVMGFLVAWTPYATVACWIFNNKGAEFSVTFMTVPAFFSKSSCIYNPIIYVLLNKQ 0
VVLTSLPGKTRRMKKVERSQSSNSNVVIEVKESSMAYSTSRESCLLSRAATKRLAGKTKSIVDLVDEFGLQETAPHKESLV*
0 FRNCMVTTICCGKNPFGDEDASSSVSQSKTEVSSVSSSQVAPA* 0
 
   
>MEL2_galGal melanopsin2 GRID2 SMARCAD1 PGDS MEL2 SEC24B COL25A1
>RHO2_neoFor Neoceratodus forsteri (lungfish) Deut.Sarc.Dipn EF526299 17961206 full Gt
0 M 0
0 MNGTEGINFYVPHSNKTGVVRSPFEYPQYYLADPWKYSIVCAYMFFLIITGLPINLLTLVVTFKHKKLRQPLNYILVNLAVADLFMVCFGFTVTFSTAINGYFIFGPRGCAIEGFMATLG 1
0 DLNMGTQPHSVTKSEIPDHVLYTVGTCVLVIGSIGIIGNLLVLYAFYS 2
  2 GEVALWSLVVLAIERYIVVCKPMGNFRFSNNHSIIGIVFTWLAALSCAAPPLFGWSR 2
1 NKKLRTPQNFFIMNLAVSDFLMSASQAPICFVNSLHREWILGDI 1
1 YLPEGMQCSCGPDYYTMNPDYHNESFVIYMFVVHFFIPVIVIFVSYGRLICKVKE 0
2 GCDLYAFCGALFGITSMMTLLAISVDRYLVITKPLRSIQWTSKKRTIQIIAAVWLYSLGW 1
0 AAAQQQESASTQKAEREVTRMVILMVIGFMTAWTPYATVAFWIFMNKGAEFGATFMAAPAFFSKSSALYNPIIYVLMNKQ 0
2 SVAPLLGWSSYVPEGLMISCTWDYVTYSPANRSYTMILCCCVFFIPLIIILHCYLFMFLAIRSTGR 2
0 FRNCMVTTLCCGKNPFGDDDVSSSVSAGKTEVSSVSSSQVSPA* 0
1 DVQKLGSCSRKSFLSQSMKNEWKLAKIAFVVIIVYVLSWSPYACVTLIAWAG 2
1 RGNTLTPYSKSVPAVIAKASAIYNPIIYAIIHPRYRK 2
>RHO2_latCha Latimeria chalumnae (coelacanth) Deut.Sarc.Coel AH007713 10339578 full Gt RH2
1 TIHNAVPCLRFLIRISKNDLLRGSINESSFRTSLSSHQSLAGRTKNTCVSSVSTGEA 0
0 MNGTEGMNFYVPLSNRTGLVRSPFEYTQYYLAEPWKFSVLCAYMFLLIILGFPINFLTLLVTFKHKKLRQPLNYILVNLAVASLFMVVFGFTVTFYSSLNGYFVLGPMGCAMEGFFATLG 1
0 NWSDVELDTVEPAHEKLQPRRSHSFSSSLRQKRDLLPDSYSCSEETEEK 0
2 GQVALWSLVVLAIERYIVVCKPMGNFRFASSHAIMGIAFTWIMALACAAPPLVGWSR 2
0 VSLSSSYLEKVLGRSAFPSSPVALVTSSLRAASLPVGLNSSSASRGAGSDISQMKTEESHNNGGLDSIVSNTVPQIIIIPTSETNLFQEEPEEEETELFHFHDKKNNLLDLEGLSSSTEFLEAVEKFLS* 0
  1 YIPEGLQCSCGPDYYTLNPDFHNESYVMYLFLVHFLLPIIIIFFTYGRLICKVKE 0
 
0 AAAQQQESASTQKAEKEVTRMVILMVIGFLTAWVPYASAAFWIFCNRGAEFTATLMTVPAFFSKSSCLFNPIIYVLLNKQ 0
>MEL2_anoCar melanopsin2 frag GRID2 SMARCAD1 MEL2 PDILM5 BMPR1B UNC5B
  0 FRNCMITTLCCGKNPLGDDDTSSAVSQSKTDVSSVSSSQVSPA* 0
0 MGPHHRTKVDVPDHVLYTVGSCVLVIGCIGITGNLLVLYAFYS 2
   
1 NKRLRTPPNYFIMNLAVSDFLMSATQAPICFLNSMHKEWVLGDI 1
  >RHO2_danRer Danio rerio (zebrafish) Deut.Acti.Otoc genomic 15647516 full G? opn1mw1 ancestral representing 4x expansion
2 GCNLYAFCGALFGITSMITLLAISVDRYCVITKPLQSIKRTSKKRTCIIIVFVWLYSLGWSVCPLFGW 1
  0 MNGTEGNNFYIPMSNRTGLVRSPYEYPQYYLAEPWQFKLLAVYMFFLICLGFPINGLTLLVTAQHKKLRQPLNFILVNLAVAGTIMVCFGFTVTFYSAINGYFVLGPTGCAIEGFMATLG 1
2 SSYIPEGLMISCTWDYVTYSPANRSYTMMLCCCVFFIPLVIIFHCYIFMFLAIRSTGR 2
2 GEVALWSLVVLAIERYIVVCKPMGSFKFSSSHAMAGIAFTWVMAMACAAPPLFGWSR 2
1 RKSSISHSIKSEWKLAKIAFVAIVVFVLSWSPYACVTLISWAG 2
1 YIPEGMQCSCGPDYYTLNPEYNNESYVLYMFICHGIVPVTIIFFTYGRLVCTVKA 0
1 TLTPYSKSVPAVIAKASAIYNPIIYAIIHPRYRK 2
  0 AAAQQQESESTQKAEREVTRMVILMVLGFLVAWTPYATVAAWIFFNKGAAFSAQFMAVPAFFSKSSALFNPIIYVLLNKQ 0
 
  0 FRNCMLTTLFCGKNPLGDDESSTVSTSKTEVSSVSPA* 0
>MEL2_xenLae Xenopus laevis melanopsin (Xmop) GRID2 SMARCAD1 PGDS MEL2 SEC24B COL25A1 21 12 12 21 21 21 00 00
   
0 MDLGKTVEYGTHRQDAIAQIDVPDQVLYTIGSFILIIGSVGIIGNMLVLYAFYR 2
>RHO2a_danRer Danio rerio (zebrafish) Deut.Acti.Otoc NM_131253 15647516 full G? opn1mw1
1 NKKLRTAPNYFIINLAISDFLMSATQAPVCFLSSLHREWILGDI 1
  0 MNGTEGSNFYIPMSNRTGLVRSPYDYTQYYLAEPWKFKALAFYMFLLIIFGFPINVLTLVVTAQHKKLRQPLNYILVNLAFAGTIMVIFGFTVSFYCSLVGYMALGPLGCVMEGFFATLG 1
2 GCNVYAFCGALFGITSMMTLLAISINRYIVITKPLQSIQWSSKKRTSQIIVLVWMYSLMWSLAPLLGW 1
  2 GQVALWSLVVLAIERYIVVCKPMGSFKFSANHAMAGIAFTWFMACSCAVPPLFGWSR 2
2 SSYVPEGLRISCTWDYVTSTMSNRSYTMMLCCCVFFIPLIVISHCYLFMFLAIRSTGR 2
  1 YLPEGMQTSCGPDYYTLNPEYNNESYVMYMFSCHFCIPVTTIFFTYGSLVCTVKA 0
1 NVQKLGSYGRQSFLSQSMKNEWKMAKIAFVIIIVFVLSWSPYACVTLIAWAG 2
0 AAAQQQESESTQKAEREVTRMVILMVLGFLFAWVPYASFAAWIFFNRGAAFSAQAMAVPAFFSKTSAVFNPIIYVLLNKQ 0
1 HGKSLTPYSKTVPAVIAKASAIYNPIIYGIIHPKYRE 2
0 FRSCMLNTLFCGKSPLGDDESSSVSTSKTEVSSVSPA* 0
1 TIHKTVPCLRFLIREPKKDIFESSVRGSIYGRQSASRKKNSFISTVSTAET 0
0 VSSHIWDNTPNGHWDRKSLSQTMSNLCSPLLQDPNSSHTLEQTLTWPDDPSPKEILLPSSLKSVTYPIGLESIVKDEHTNNSCVR
>RHO2b_danRer Danio rerio (zebrafish) Deut.Acti.Otoc NM_182891 15647516 full G? opn1mw2 highest expression
NHRVDKSGGLDWIINATLPRIVIIPTSESNISETKEEHDNNSEEKSKRTEEEEDFFNFHVDTSLLNLEGLNSSTDLYEVVERFLS* 0
0 MNGTEGNNFYIPMSNRTGLVRSPYEYTQYYLADPWQFKALAFYMFFLICFGLPINVLTLLVTAQHKKLRQPLNYILVNLAFAGTIMAFFGFTVTFYCSINGYMALGPTGCAIEGFFATLG 1
 
  2 GQVALWSLVVLAIERYIVVCKPMGSFKFSSNHAMAGIAFTWVMASSCAVPPLFGWSR 2
>MEL_Platynereis dumerilii mRNA for rhabdomeric opsin runs as melanopsin unavailable genomically
1 YIPEGMQTSCGPDYYTLNPEFNNESYVLYMFSCHFCVPVTTIFFTYGSLVCTVKA 0
MSRSEVLVPGSMSLDGLLTTAHPIGNDSIETILHPYWQQFDIENTIPDSWHYAVAAWMTFFGILGVSGNLLVVWTFLKTKSLRTAPNMLLVNLAIGDMAFSA
  0 AAAQQQESESTQKAEREVTRMVILMVLGFLVAWVPYASFAAWIFFNRGAAFSAQAMAIPAFFSKASALFNPIIYVLLNKQ 0
INGFPLLTISSINKRWVWGKLWRELYAFVGGIFGLMSINTLAWIAIDRFYVITNPLGAAQTMTKKRAFIILTIIWANASLWALAPFFGWGAYIPEGFQTSCTYDYLTQDMNNYTYV
  0 FRSCMLNTLFCGKSPLGDDESSSVSTSKTEVSSVSPA* 0
LGMYLFGFIFPVAIIFFCYLGIVRAIFAHHAEMMATAKRMGANTGKADADKKSEIQIAKVAAMTIGTFMLSWTPYAVVGVFGMIKPHSEMFIHPLLAEIPVMMAKASARYNPIIYA
   
LSHPKFRAEIDKHFPWLLCCCKPKPKAQLPSSTTKGSIASKTEADTSV*
  >RHO2c_danRer Danio rerio (zebrafish) Deut.Acti.Otoc NM_182892 15647516 full G? opn1mw3
 
0 MNGTEGNNFYIPMSNRTGLVRSPYEYPQYYLAEPWQFKLLAVYMFFLMCFGFPINGLTLVVTAQHKKLRQPLNFILVNLAVAGTIMVCFGFTVTFYTAINGYFVLGPTGCAIEGFMATLG 1
Here are those sequences aligned to show rare genomic events such as indels and intron gains and losses:
2 GQISLWSLVVLAIERYIVVCKPMGSFKFSSNHAFAGIGFTWIMALSCAAPPLVGWSR 2
 
1 YIPEGMQCSCGPDYYTLNPDYNNESYVLYMFCCHFIFPVTTIFFTYGRLVCTVKA 0
>RHO1_homSap LAAYMFLLIVLGFPINFLTLYVTVQHKKLRTPLNYILLNLAVADLFMVLGGFTSTLYTSLHGYFVFGPTGCNLEGFFATLG GEIALWSLVVLAIERYVVVCKPMSNFRFGENHAIMGVAFTWVMALACAAPPLAGWS
0 AAAQQQESESTQKAEREVTRMVILMVLGFLVAWTPYASVAAWIFFNRGAAFSAQFMAVPAFFSKSSSIFNPIIYVLLNKQ 0
>RHO1_monDom LAAYMFMLIVLGFPINFLTLYVTIQHKKLRTPLNYILLNLAIADLFMVFGGFTMTLYTSLHGYFVFGPTGCNLEGFFATLG GEIALWSLVVLAIERYVVVCKPMSNFRFGENHAIIGVAFTWVMALACAFPPLIGWS
0 FRNCMLTTLFCGKNPLGDDESSTVSTSKTEVSSVSPA* 0
>RHO1_ornAna LAAYMFMLIMLGFPINFLTLYVTIQHKKLRTPLNYILLNLAFANHFMVLGGFTTTLYTSLHGYFVFGPTGCNIEGFFATLG GEIALWSLVVLAIERYIVVCKPMSNFRFGENHAIMGVAFTWIMALACALPPLVGWS
>RHO1_galGal LAAYMFMLILLGFPVNFLTLYVTIQHKKLRTPLNYILLNLVVADLFMVFGGFTTTMYTSMNGYFVFGVTGCYIEGFFATLG GEIALWSLVVLAVERYVVVCKPMSNFRFGENHAIMGVAFSWIMAMACAAPPLFGWS
>RHO2d_danRer Danio rerio (zebrafish) Deut.Acti.Otoc NM_131254 15647516 full G? opn1mw4
>RHO1_anoCar LAAYMFLLILLGFPINFLTLFVTIQHKKLRTPLNYILLNLAVANLFMVLMGFTTTMYTSMNGYFIFGTVGCNIEGFFATLG GEMGLWSLVVLAVERYVVICKPMSNFRFGETHALIGVSCTWIMALACAGPPLLGWS
0 MNGTEGNNFYIPLSNRTGLARSPYEYPQYYLAEPWQFKLLAVYMFFLICLGFPINGLTLLVTAQHKKLRQPLNFILVNLAVAGTIMVCFGFTVTFYTAINGYFVLGPTGCAIEGFMATLG 1
>RHO1_xenTro LAAYMFLLILLGFPINFMTLYVTIQHKKLRTPLNYILLNLVFANHFMVLCGFTVTMYTSMHGYFIFGQTGCYIEGFFATLG GEMALWSLVVLAIERYVVVCKPMANFRFGENHAIMGVVFTWIMALSCAAPPLFGWS
2 GEVALWSLVVLAVERYIVVCKPMGSFKFSASHAFAGCAFTWVMAMACAAPPLVGWPR 2
>RHO1_danRer VAAYMFFLIITGFPVNFLTLYVTIEHKKLRTPLNYILLNLAIADLFMVFGGFTTTMYTSLHGYFVFGRLGCNLEGFFATLG GEMGLKSLVVLAIERWMVVCKPVSNFRFGENHAIMGVAFTWVMACSCAVPPLVGWS
1 YIPEGMQCSCGPDYYTLNPEYNNESYVLYMFICHFILPVTIIFFTYGRLVCTVKA 0
>RHO1_Raja  LAAYMFFLILTGLPVNFLTLFVTIQHKKLRQPLNYILLNLAVSDLFMVFGGFTTTIITSMNGYFIFGPAGCNFEGFFATLG GEVGLWCLVVLAIERYMVVCKPMANFRFGSQHAIIGVVFTWIMALSCAGPPLVGWS
0 AAAQQQESESTQKAEREVTRMVILMVLGFLIAWTPYATVAAWIFFNKGAAFSAQFMAVPAFFSKTSALYNPVIYVLLNKQ 0
>RHO1_lamp1 LAAYMFFLILVGFPVNFLTLFVTVQHKKLRTPLNYILLNLAVANLFMVLFGFTLTMYSSMNGYFVFGPTMCNFEGFFATLG GEMSLWSLVVLAIERYIVICKPMGNFRFGSTHAYMGVAFTWFMALSCAAPPLVGWS
0 FRNCMLTTLFCGKNPLGDDESSTVSTSKTEVSSVSPA* 0
>RHO1_lamp2 LAAYMFFLILVGFPVNFLTLFVTVQHKKLRTPLNYILLNLAVSNLFMILFGFTTTMYTSMNGYFVFGPTMCSIEGFFATLG GEVSLWSLVVLAIERYIVICKPMGNFRFGNTHAIMGVALTWVMALSCAAPPLLGWS
>RHO1_lamp3 LAAYMFFLILVGFPVNFLTLFVTVQHKKLRTPLNYILLNLAMANLFMVLFGFTVTMYTSMNGYFVFGPTMCSIEGFFATLG GEVALWSLVVLAIERYIVICKPMGNFRFGNTHAIMGVAFTWIMALACAAPPLVGWS
>RHO2_tetNig Tetraodon nigroviridis (pufferfish) Deut.Acti.Perc genomic full G? RH2
>RHO2_galGal VCCYIFFLISTGLPINLLTLLVTFKHKKLRQPLNYILVNLAVADLFMACFGFTVTFYTAWNGYFVFGPVGCAVEGFFATLG GQVALWSLVVLAIERYIVVCKPMGNFRFSATHAMMGIAFTWVMAFSCAAPPLFGWS
0 MVWDGGIEPNGTEGKNFYIPMSNRTGIVRSPFEYPQYYLVDPIMFKMLALYMFFLICTGTPINGLTLLVTAQNKKLRQPLNYILVNLAVAGLIMCAFGFTITITSAINGYFILGATACAVEGFMATLG 1
>RHO2_anoCar VCCYIFFLIFTGLPINILTLLVTFKHKKLRQPLNYILVNLAVADLFMACFGFTVTFYTAWNGYFIFGPIGCAIEGFFATLG GQVALWSLVVLAIERYIVVCKPMGNFRFSATHALMGISFTWFMSFSCAAPPLLGWS
2 GEVALWSLVVLAIERYIVVCKPMGSFKFTGTHAAVGVLFTWIMAFACAGPPLFGWSR 2
>RHO2_Gekko LSFYMFFLIAAGMPLNGLTLFVTFQHKKLRQPLNYILVNLAAANLVTVCCGFTVTFYASWYAYFVFGPIGCAIEGFFATIG GQVALWSLVVLAIERYIVICKPMGNFRFSATHAIMGIAFTWFMALACAGPPLFGWS
1 YLPEGMQCSCGPDYYTLAPGYNNESYVIYMFVVHFFVPVFLIFFTYGSVVLTVka 0
>RHO2_Lat    LCAYMFLLIILGFPINFLTLLVTFKHKKLRQPLNYILVNLAVASLFMVVFGFTVTFYSSLNGYFVLGPMGCAMEGFFATLG GQVALWSLVVLAIERYIVVCKPMGNFRFASSHAIMGIAFTWIMALACAAPPLVGWS
0 AAAQQQESESTQKAQREVTRMCILMVLGFLVAWTPYATFSGWIFMNKGAAFHPLTAALCAFFAKSSALYNPVIYVLM 0
>RHO2_Geo    ISAYVFTLILIGFPVNFMTLFVTFKLKKLRQPLNFILVNLCVADLLMIMFGFTTTFYTAMNGYFVFGPTGCNIEGFFATLG GEVSLWSLVMLAIERYIVVCKPMGNFRFATTHAALGVVFTWVMASACAVPPLVGWS
0 FRNCMLSTIGMGGAVDDETSVSASKTEVSSVS* 0
>SWS1_homSap QAAFMGTVFLIGFPLNAMVLVATLRYKKLRQPLNYILVNVSFGGFLLCIFSVFPVFVASCNGYFVFGRHVCALEGFLGTVA GLVTGWSLAFLAFERYIVICKPFGNFRFSSKHALTVVLATWTIGIGVSIPPFFGWS
>SWS1_macDom QTVFMGFVFCAGTPLNAVVLVATLRYKKLRQPLNYILVNVSLCGFIFCIFAVFTVFISSSQGYFIFGRHVCAMEAFLGSVA GLVTGWSLAFLAFERFIVICKPFGNFRFNSKHAMMVVLATWVIGIGVSIPPFFGWS
>RHO2_takRub Takifugu rubripes (fugu) Deut.Acti.Perc AF226989 10692583 full G?
>SWS1_galGal QTAFMGIVFAVGTPLNAVVLWVTVRYKRLRQPLNYILVNISASGFVSCVLSVFVVFVASARGYFVFGKRVCELEAFVGTHG GLVTGWSLAFLAFERYIVICKPFGNFRFSSRHALLVVVATWLIGVGVGLPPFFGWS
0 MAWDGGIEPNGTEGKNFYIPMSNRTGIVRSPFEYPQYYLADPIMFKILALYMFFLICTGTPINGLTLLVTAQNKKLRQPLNYILVNLAVAGLIMCAFGFTITITSAVNGYFILGATACAVEGFMATLG 1
>SWS1_Taenio QTIFMGLVFVAGTPLNAIVLIVTIKYKKLRQPLNYILVNISVSGLMCCVFCIFTVFIASSQGYFVFGKHMCAFEGFAGATG GLVTGWSLAFLAFERYIVICKPFGNFRFNSRHALLVVAATWIIGVGVAIPPFFGWS
  2 GEIALWSLVVLAVERYVVVCKPMGSFKFTGTHAAVGVAFTWIMAFACAAPPLFGWSR 2
>SWS1_Gekko QTAFMGFVFFVGTPLNAIILFAIVKYKKLRQPLNYILVNISAAGFLFCVVAVFTVFISSSQGYFIFGKHICALEAFLGSLA GLVTGWSLAFLALERYIVICKPFGNFRFSAKHASLVVAATWFIGIGVSIPPYFGWS
  1 YLPEGMQCSCGPDYYTLAPGYNNESYVIYMFSCHFFVPVITIFFTYGSLVLTVKA 0
>SWS1_Utasta QTAFMGFVFFAGTPLNAIILIVTVKYKKLRQPLNYILVNISFAGFLFCVFSVFTVFLASSQGYFFFGRHICALEAFLGSVA GLVTGWSLAFLAFERYIVICKPFGNFRFNSKHALLVVAATWFIGIGVSIPPFFGWS
  0 AAAQQQESESTQKAQKEVTRMCILMVFGFLMAWTPYATFSAWIFMNKGAAFHPLTAAVCAFFAKSSALYNPVIYVLLNKQ 0
>SWS1_Xenlae QAIFMGMVFLIGTPLNFIVLLVTIKYKKLRQPLNYILVNITVGGFLMCIFSIFPVFVSSSQGYFFFGRIACSIDAFVGTLT GLVTGWSLAFLAFERYIVICKPMGNFNFSSSHALAVVICTWIIGIVVSVPPFLGWS
  0 FRNCMLSTIGMGGAVDDETSVSASKTEVSSVS* 0
>SWS1_Danio QAAFMGFVFIVGTPMNGIVLFVTMKYKKLRQPLNYILVNISLAGFIFDTFSVSQVSVCAARGYYSLGYTLCSMEAAMGSIA GLVTGWSLAVLAFERYVVICKPFGSFKFGQGQAVGAVVFTWIIGTACATPPFFGWS
   
>SWS1_Oryzia QAAFMGFVFFVGTPLNFVVLLATAKYKKLRVPLNYILVNITFAGFIFVTFSVSQVFLASVRGYYFFGQTLCALEAAVGAVA GLVTSWSLAVLSFERYLVICKPFGAFKFGSNHALAAVIFTWFMGVGCACPPFFGWS
  >RHO2_gasAcu Gasterosteus aculeatus (stickleback) Deut.Acti.Perc genomic full G? 2nd near-identical tandem copy
>SWS1_Geotri QAAFMGFVFICGTPLNAIVLVVTIKYKKLRQPLNYILVNISAAGLVFCLFSISTVFVASMQGYFFLGPTICALEAFFGSLA GLVTGWSLAFLAAERYIVICKPFGNFRFGSKHALVAVGLTWMLGLSVALPPFFGWS
0 MAWEGGLEPNGTEGKNFYIPMSNRTGVVRSPFEYQQYYLADPIMFKILALYMFFLICTGTPINGLTLLVTAQNKKLRQPLNYILVNLAVAGLIMCAFGFTITITSAVNGYFILGATACAVEGFMATLG 1
>SWS2_ornAna LAAFMFLLITLGFPINLLTVICTIKYKKLRSHLNYILVNLAVSNMLVVCVGSATAFYSFAHMYFVLGPTACKIEGFAATLG GMVSLWSLAVIAFERFLVICKPLGNLSFRGTHAIFGCAATWVFGLAASLPPLFGWS
2 GEVALWSLVVLAVERYIVVCKPMGSFKFSGTHAGAGVLFTWIMAMACAAPPLFGWSR 2
>SWS2_galGal MAAFMFLLIALGVPINTLTIFCTARFRKLRSHLNYILVNLALANLLVILVGSTTACYSFSQMYFALGPTACKIEGFAATLG GMVSLWSLAVVAFERFLVICKPLGNFTFRGSHAVLGCVATWVLGFVASAPPLFGWS
1 YLPEGMQCSCGPDYYTLAPGFNNESYVIYMFVVHFFTPVFIIFFTYGSLVLTVKA 0
>SWS2_Taenio MAAFMFLLVLLGVPINALTVLCTAKYKKLRSHLNYILVNLAVANLLVVCVGSTTAFYSFSQMYFALGPLACKIEGFTATLG GMVSLWSLAVVAFERFLVICKPLGNFTFRGSHAVLGCAITWIFGLIASLPPLFGWS
0 AAAQQQESESTQKAEREVTRMCILMVFGFLVAWVPYASFAGWIFLNKGAPFSALTAAIPAFFAKSSALYNPVIYVLLNKQ 0
>SWS2_Utasta MAAFMFLLIILGVPINVLTIFCTFKYKKLRSHLNYILVNLAVSNLLVVCIGSTTAFYSFAQMYFSLGPTACKIEGFAATLG GMVSLWSLAVVAFERFLVICKPLGNFSFRGTHAIIGCIITWVFGLVASLPPLFGWS
0 FRNCMLTTIGMGGMVEDETSVSASKTEVSSVS* 0
>SWS2_Xenopu ISAFMLFTIIFGFPLNLLTIICTVKYKKLRSHLNYILVNLAVANLIVICFGSTTAFYSFSQMYFSLGTLACKIEGFTATLG GIIGLWSLAVVAFERFLVICKPMGNFTFRESHAVLGCILTWVIGLVAAIPPLLGWS
>SWS2_Danio MSAFMLFLFIAGTAINVLTIVCTIQYKKLRSHLNYILVNLAISNLWVSVFGSSVAFYAFYKKYFVFGPIGCKIEGFTSTIG GMVSLWSLAVVALERWLVICKPLGNFTFKTPHAIAGCILPWCMALAAGLPPLLGWS
>RHO2_oryLat Oryzias latipes (medaka) Deut.Acti.Perc AB001603 9463691 full G?
>SWS2_Takifu MSAFMFFLFVAGTGINVLTIACTIQYKKLRSHLNYILVNLAFSNLLVTTVGSFTCFCCFFVRYMIVGPLGCKIEGFAATLG GMVSLWSLAVVAFERWLVVCKPLGNFIFKPDHAIVCCIFTWFFALIISAPPLFGWS
0 MENGTEGKNFYIPMNNRTGLVRSPYEYPQYYLADPWQFKLLGIYMFFLILTGFPINALTLVVTAQNKKLRQPLNFILVNLAVAGLIMVCFGFTVCIYSCMVGYFSLGPLGCTIEGFMATLG 1
>SWS2_Geotri MSAFMLFLVLAGFPLNFLTVFVTIKYKKLRSHLNYILVNLAIANLIVVCCGSTLAFYSFMHKYFILGPLFCKMEGFTATLG GMLSLWSLAVLAFERCLVICKPFGNIAFRGTHALIRCGFAWAAAIAASTPPLFGWS
2 GQVSLWSLVVLAIERYIVVCKPMGSFKFTATHSAAGCAFTWIMASSCAVPPLVGWSR 2
>LWS_ornAna TSLWMIFVVIASVFTNGLVLVATMKFKKLRHPLNWILVNLAVADLGETLIASTISVINQIFGYFILGHPMCVLEGYTVSLC GITGLWSLSIISWERWIVVCKPFGNVKFDAKLAMVGIVFSWVWAAVWTAPPIFGWS
1 YIPEGIQVSCGPDYYTLAPGFNNESFVMYMFSCHFCVPVFTIFFTYGSLVMTVKA 0
>LWS_galGal TSLWMIFVVAASVFTNGLVLVATWKFKKLRHPLNWILVNLAVADLGETVIASTISVINQISGYFILGHPMCVVEGYTVSAC GITALWSLAIISWERWFVVCKPFGNIKFDGKLAVAGILFSWLWSCAWTAPPIFGWS
  0 AAAQQQDSASTQKAEKEVTRMCFLMVLGFLLAWVPYASYAAWIFFNRGAAFSAMSMAIPSFFSKSSALFNPIIYILLNKQ 0
>LWS_anoCar TSVWMIFVVIASIFTNGLVLVATAKFKKLRHPLNWILVNLAIADLGETVIASTISVINQISGYFILGHPMCVLEGYTVSTC GISALWSLAVISWERWVVVCKPFGNVKFDAKLAVAGIVFSWVWSAVWTAPPVFGWS
  0 FRNCMLATIGMGGMVEDETSVSTSKTEVSTAA* 0
>LWS_Lithoch ATLWMFVVVVLSVFTNGLVLVATMKFKKLRHPLNWILVNLAIADLGETVFASTISVCNQFFGYFILGHPMCIFEGYVVSVC GIAALWSLTIISWERWIVVCKPFGNVKFDAKWATAGIVFSWVWAAVWCAPPIFGWS
>LWS_Gastero STLWMFIVVALSVFTNGLVLVATAKFKKLQHPLNWILVNLAIADLGETVFASTISVCNQFFGYFILGHPMCVFEGYVVSVC GITALWSLTIISWERWIVVCKPFGNVKFDAKWATAGIVFSWIWSAVWCAPPIFGWS
>RHO2_oreNil Oreochromis niloticus (tilapia) Deut.Acti.Perc AF247124 11470845 full G?
>LWS_Petrom TSVWMIIVVVLSLFSNGLVLVATVKFKKLRHPLNWIIVNLAIADILETIFASTISVCNQVYGYFILGHPMCVFEGYVVSTC GIAGLWSLAIISWERWMVVCKPFGNIKFDGKIATILIVFSWVWPASWCSLPIFGWS
0 MAWEGGIEPNGTEGKNFYIPMSNRTGIVRNPFEYSQYYLADPIFFKLLAFYMFFLICTGTPINGLTLFVTAQNKKLRQPLNYILVNLAVAGLIMCCFGFTITITSAINGYFVLGTTFCAIEGFMATLG 1
>LWS_lamprey TSVWMIIVVVLSLFTNGLVLVATMKFKKLRHPLNWILVNLAIADILETIFASTISVCNQVFGYFILGHPMCVFEGYVVSTC GIAGLWSLAIISWERWMVVCKPFGNIKFDGKIAIILIVFSWVWPACWCSLPIFGWS
2 GEVALWSLVVLAVERYIVVCKPMGSFKFTGAHAGAGVLFTWIMAMACAAPPLFGWSR 2
>LWS_Geotria TSFWMIIVVILSLFTNGLVLVATLKFKKLRHPLNWILVNLAIADIGETIFASTVSVVNQIFGYFILGHPLCVFEGFTVSVC GITALWSLAIISFERWMVVCKPFGNLKFDGKVAIVLIIFSWAWSAGWCAPPIFGWS
1 YIPEGMQCSCGPDYYTLAPGFNNESYVIYMFVVHFFVPVFIIFFTYGSLVMTVRA 0
>PIN_galGal VAVLMGTVVACASVVNGLVIVVSICYKKLRSPLNYILVNLAVADLLVTLCGSSVSLSNNINGFFVFGRRMCELEGFMVSLT GIVGLWSLAILALERYVVVCRPLGDFQFQRRHAVSGCAFTWGWALLWSTPPLLGWS
0 AAAQQQDSASTQKAEKEVTRMCVLMVMGFLIAWTPYASFAGWIFLNKGAAFSALTAAIPAFFAKSSALYNPIIYVLMNKQ 0
>PIN_UtaSta VAVLMGLVVVSAAFVNGLVIVVSIQYKKLRSPLNYILVNLAIADLLVTSFGSTLSFANNIYGFFVLGQTACEFEGFMVSLT GIVGLWSLAILAFERYLVICKPVGDFRFQQRHAVFGCVFTWMWSLVWTLPPLFGWS
0 FRNCMLSTIGMGGMVEDETSVSTSKTEVSSVS* 0
>PIN_pheMad LAALMGVVVLSASLANGLVIAVSVRFKRLRSPLNYILVNLATADLLVTFFGSIISFVNNAVGFFVFGKTACRFEGFMVSLT GIVGLWSLAILAFERYLVICKPVGDFQFQRRHAVIGCLYTWGWSLIWTVPPLFGWS
>PIN_podSic VAVLMGLVVISATLVNGLVIVVSVQFKKLRSPLNYVLVNLAVADLLVTFFGSTISFVNNAQGFFIFGQATCEFEGFMVSLT GIVGLWSLAILAFERYLVICKPVGDFRFPARHAVLGCAFTWGWSFVWTVPPLLGWS
>RHO2_hipHip Hippoglossus hippoglossus (halibut) Deut.Acti.Perc AF156263 11925012 full G?
>PIN_xenTro VAAVMCMVVILAFFVNGLVIVVTLKYKKLRSPLNYILVNLAIANLLVTIFGSSVSFSNNVVGYFFMGKTMCEFEGFMVSLT GIVGLWSLAILAFERYLVICKPMGDFRFQQKHAILGCSFTWVWSFIWTSPPLFGWC
0 MVWDGGIEPNGTEGKNFYIPMSNRTGIVRSPFEYPQFYMVDSMMFKFLAFYMFFLVCTGTPINGLTLFVTAQNKKLRQPLNYILVNLAVAGLIMCCFGFTITITSAFNGYFILGATFCTIEGFMATLG 1
>PIN_bufJap VAVLMGMVVFLAFFVNGMVIVVSLKYKKLRSPLNYILVNLAVADILVTMFGSTVSFHNNIFGFFTLGKLVCELEGFVVSLT GIVGLWSLAILAFERYIVICKPMGDFRFQQRHAVMGCAFTWIWAFLWTSPPLIGWC
2 GEVALWSLVVLAVERYIVVCKPMGSFKFSGTHAGIGVLFTWVMAFACAGPPLFGWSR 2
>VAOP_galGal VAAVMFVVTSLSLAENLAVILVTFKFKQLRQPVNYVIVNLSVADFLVSLTGGTISFLANLKGYFYMGHWACVLEGFAVTFF GIVALWSLALLAFERYIVICRPVGNMRLRGKHAAQGIAFVWTFSFIWTIPPTMGWS
1 YIPEGMQCSCGPDYYTLAPGFNNESYVIYMFVVHFFLPVFVIFFTYGSLVLTVKA 0
>VAOP_anoCar ISALMFVVTLFSLSENFTVILVTIKFKQLRQPLNYVIVNLSVADFLVSLIGGTISFSTNLKGYFYMGHWACVLEGFAVTFF GIVALWSLALLAFERYVVICRPLGNMRLNGKHAALGVAFVWIFSFIWTVPPTMGWS
0 AAAQQQESESTQKAEKEVTRMCILMVFGFLFAWTPYATFAGWIFMNKGAAFTALTASIPAFFAKSSALYNPVIYVLLNKQ 0
>VAOP_xenTro LAALMFVVTSLSIAENFIVILVTAKFKQLRQPLNYIIVNLSVADFLVSVIGGTISIATNSRGYFYLGSWACVLEGFAVTFF GIVALWSLSVLAFERYIVICRPLGNLRLQGKHSALAIIFVWVFSFVWTIPPTMGWS
0 FRNCMLSTIGMGGMVEDESSVSASKTEVSSVS* 0
>VAOP_danRer LAALMFVVTALSLSENFTVMLVTFRFQQLRQPLNYIIVNLSLADFLVSLTGGSISFLTNYHGYFFLGKWACVLEGFAVTFF GIVALWSLAVLAFERFFVICRPLGNIRLRGKHAALGLVFVWSFSFIWTVPPVLGWS
>VAOP_rutRut LATLMFVVTAASLSENFAVMLVTFRFTQLRKPLNYIIVNLSLADFLVSLTGGTISFLTNYHGYFFLGKWACVLEGFAVTYF GIVALWSLAVLAFERFFVICRPLGNIRLRGKHAALGLLFVWTFSFIWTIPPVLGWS
>RHO2_mulSur Mullus surmuletus (mullet) Deut.Acti.Perc Y18680 full G?
>VAOP_Petro LAALMGTITALSLGENFAVIVVTARFRQLRQPLNYVLVNLAAADLLVSAIGGSVSFFTNIKGYFFLGVHACVLEGFAVTYF GVVALWSLALLAFERYFVICRPLGNFRLQSKHAVLGLAVVWVFSLACTLPPVLGWS
0 MNGTEGKNFYIPMSNRTGIVRSPFEYPQYYMVDPMIYKLLAFYMFFLICTGTPINGLTLLVTFQNKKLQQPLNYILVNLAVVGLIMCAFGFTITITSALNGYFILGPTFCAIEGFMATLG 1
>PPIN_anaCar IAIIMATSCTLSVILNTAVIAITIKYRQLRQPINYSLVNLAIADLGAALLGGSLNVETNAVGYYNLGRVGCVTEGFAMAFF GIVALCTIAVIAVDRAIVIAKPMGTITFTTRKAMIGVAVSWIWSLVWNTPPLFGWG
2 GEVALWSLVVLAVERYIVVCKPMGSFKFSGTHAGAGVAFTWIMAFACAGPPLFGWSR 2
>PPIN_Xenop LALIMAVFCAAALFLNVTVIVVTFKYRQLRHPINYSLVNLAIADLGVTVLGGALTVETNAVGYFNLGRVGCVIEGFAVAFF GIAALCTIAVIALDRVFVVCKPMGTLTFTPKQALAGIAASWIWSLIWNTPPLFGWG
1 YLPEGMQCSCGPDYYTLAPGFNNESYVIYMFVVHFFVPVFVIFFTYGSLVLTVKA 0
>PPIN_Ictal LSIIMALSSTFGIILNMVVIIVTVRYKQLRQPLNYALVNLAVADLGCPVFGGLLTAVTNAMGYFSLGRVGCVLEGFAVAFF GIAGLCSVAVIAVDRYMVVCRPLGAVMFQTKHALAGVVFSWVWSFIWNTPPLFGWG
0 AAAQQQESESTQKAEREVTRMCILMVIGFLVAWVPYATFAGWIFLNKGAAFTALTAALPAFFAKSSALYNPVIYVMMNKQ 0
>PPIN_Danio LAVIIGVFSVCGVILNVTVITVTLKYKQLRQPLNFALVNLAVADLGCAVFGGLPTVVTNAMGYFSLGRVGCVLEGFAVAFF GIAALCSVAVIALERCMVVCRPVGSISFQTRHAVFGVAVSWLWSFIWNTPPLFGWG
0 FRNCILSAIGMGGMVEDETSVSTSKTEVSTAS* 0
>PPIN_Oncor LAVIIGVFSVSGVCMNVLVIMVTMRHRKLRQPLNYALVNLAVADLGCALFGGLPTMVTNAMGYFSMGRLGCVLEGFAVAFF GIAGLCSVAVIAVDRYVVVCRPMGAVMFQTRHAVGGVVLSWVWSFLWNTPPLFGWG
>PPINa_Ciona LCVYMTFVFLLSCSLNILVIVATLKNKVLRQPLNYIIVNLAVVDLLSGFVGGFISIAANGAGYFFWGKTMCQIEGYFVSNF GVTGLLSIAVMAFERYFVICKPFGPVRFEEKHSIFGIVITWVWSMFWNTPPLIFWD
>RHO2_pomMin Pomatoschistus minutus (sand_goby) Deut.Acti.Perc Y18679 full G?
>PPINb_Ciona LAVYMTFIFLLAVSLNGFVIIATMKNKKLRQPLNYIIINLSIADFLSGLVGGFIGMISNSAGYFYFGKTVCILEGYIVSVA GVCGLMSISVMAFERYFVVCKPYGPFTLTNTHAALGIGFTWTWSVLWSTPGLIWLD
0 MNGTEGKNFYIPMSNRTGIVRSPYEYPQYYMVDPWIYKLLAFYMFFLICTGTPINALTLLVTFQNKKLRQPLNFILVNLAVAGLIMCAFGFTITITSALNGYFILGATFCAIEGFMATLG 1
>PPIN_lamp  LAVIMAVFTIASLVLNSTVVIVTLRHRQLRHPLNFSLVNLAVADLGVTVFGASLVVETNAVGYFNLGRVGCVIEGFAVAFF GIAALCTIAVIAVDRFVVVCKPLGTLMFTRRHALLGIAWAWLWSFVWNTPPLFGWG
2 GEVALWSLVVLAVERYIVVCKPMGSFKFSGAHAGAGVALTWIMAMACAAPPLFGWSR 2
>PARIE_Utast LAFLMFLNALFSIFNNSLVIAVTLKNPQLRNPINIFILNLSFSDLMMSLCGTTIVIATNYYGYFYLGRKFCIFQGFAVNYF GIVSLWSLTILA YERYNVV--CQPLGTLQMSTKR GYQLLGFIWVFCLFWAVVPLFGWS
1 YLPEGMQCSCGPDYYTLAPGFNNESYVMYMFVVHFFIPVFLIFFTYGSLVLTVKA 0
>PARIE_Anole LAFLMFINALFSLFNNFLVIAVTLKNPQLRNPINIFILNLSFSDLMMSICGTTIVIATNYHGYFYLGRRFCIFQGFAVNYF GIVSLWSLTILA YERYNVV--CQPLGTLQMSTQR AYQLLGFIWVFCLFWAVVPLFGWS
0 AAAQQQDSASTQKAEKEVTRMCFLMVMGFLVAWVPYASFAGWIFLNKGAAFTAMTAAIPAFFAKSSALYNPVIYVLMNKQ 0
>PARIE_Xenop LSFLMFLNAVFSICNNAIVILVTLKHPQLRNPINIFILNLSFSDLMMALCGTTIVVSTNYHGYFYLGKQFCIFQGFAVNYF GIVSLWSLTLLA YERYNVV--CEPIGALKLSTKR GYQGLVFIWLFCLFWAIAPLFGWS
0 FRNCMLSAVGMGGMVDDETSVSASKTEVSSVS* 0
>ENCEPH_braB VAGVIAIIGVVGFVSNGAVVVLFLKFPQLRTPFNLLLLNMAVADLLVSVCGNTLSFASAVRHRWLWGRPGCVWYGFANHLF GLVSLISLAVIS FLRYRMVVKPKGPGSSYLTYTK VGLAILFIYLYCLLWTTLPIAGWS
>ENCEPH_homS LALLLGSIGLLGVGNNLLVLVLYYKFQRLRTPTHLLLVNISLSDLLVSLFGVTFTFVSCLRNGWVWDTVGCVWDGFSGSLF GIVSIATLTVLA YERYIRVV-----HARVINFSW AWRAITYIWLYSLAWAGAPLLGWN
>RHO2_calMil Callorhinchus milii (elephantfish) Deut.Chon.Holo EF565168 19196633 full G?
>ENCEPH_monD LALLIATIGLLGLCNNLLVLVLYYKFQRLRTPTHLFLVNISFNDLLVSLFGVTFTFVSCLRSGWVWDSVGCAWDGFSNTLF GIVSIMTLTVLA YERYNRIV-----HAKVINFSW AWRAITYIWLYSLVWTGAPLLGWN
0 MNGTKGSNFYIPMSNRTGVVRNPFEYPQYYLADRWLFSSISAYMFLLICAGLPINGLTLLVTVKHKKLRQPLNFILLNLAVADLFMVFGGFFITVYTSLHGYFVFGVTGCNFEGFFATLG 1
>ENCEPH_galG LALLIATIGTLGVCNNLLVLVLYYKFKRLRTPTNLFLVNISLSDLLVSVCGVSLTFMSCLRSRWVWDAAGCVWDGFSNSLF GIVSIMTLTVLA YERYIRVV-----HAKVIDFSW SWRAITYIWLYSLAWTGAPLLGWN
2 GEIGLWSLVVLAIERYVVVCKPMSNFRFGTSHALMGMGFTWFMALTAAVPPLVGWSR 2
>ENCEPH_anoC LALLVAAIGLLGLCNNLLVLVLYAKFKRLRTPTHLFLVNISLSDLLVSLFGVSFTFGSCLRHRWVWDAAGCVWDGFSNSLF GIVSIMTLTVLA YERYIRVV-----HARVIDFSW SWRAITYIWLYSLAWTGAPLLGWN
1 FIPEGFQCSCTPDFYTTNPLYNNDSYLMYLFSVHFAFPVTLIFFSYGRLICKVKE 0
>ENCEPH_xenT LALIVATVGFLGLVNNLLVLILYCKFKRLQTPTNLLFFNTSLCHFVFSLLAITFTFMSCVRGSWAFSVEMCVFHGFSKNLL GIVSFGTLTVVA YERYARVV-----YGKYVNSSW SKRSITFVWVYSLAWTGFPLIGWN
0 AAAQQQESATTQKAEKEVTRMVILMVIGFLTAWLPYASLSIWIFTHQGAWISPLLMTIPSFFSKSSVLYNPIIYILMNKQ 0
>ENCEPH_braB IATGLALIGLVGSMNNFVVILLIGCHRQLRTPFNLLLLNVSVADLLVSVCGNTLSFASAVQHRWLWGRPGCVWYGFANSLF GIVSLVTLSALA FERYCVVV----RSSEMLTYKS SLGMIAFIWMYSLLWTSLPLLGWS
0 FRSSMITTVCCGKNPFGDDDSSSVTSQSKTEVSSVSTSQVSPA* 0
>ENCEPH_braF IATCLALIGFVGFTNNFVVILLIGCHRQLRTPFNLLLLNMSVADLLVSVCGNTLSFASAVRHRWLWGRPGCVWYGFANSLF GIVSLVTLSALA FERYCVVV----RSSDMLTYKS SLVVITFIWLYSLLWTSLPLLGWS
   
>ENCEPH2_Api AIALGFIGFFGFTANLLVAIVIVKDAQILWTPVNVILFNLVFGDFLVSIFGNPVAMVSAATGGWYWGYKMCLWYAWFMSTL GFASIGNLTVMA VERWLLVA----RPMQALSIRH AVILASFVWIYALSLSLPPLFGWG
>RHO2_geoAus Geotria australis (lamprey) Deut.Agna.Hype AY366494 17463225 full Gt RhB
>ENCEPH1_Ano AAVTLFFIGFFGFFLNIFVIALMYKDVQLWTPMNIILFNLVCSDFSVSIIGNPLTLTSAISHRWLYGKSICVAYGFFMSLL GIASITTLTVLS YERFCLIS--RPFAAQNRSKQG ACLAVLFIWSYSFALTSPPLFGWG
0 MNGTEGANFYIPFHNRTGVVRSPYEYPQYYLADPWMYSAISAYVFTLILIGFPVNFMTLFVTFKLKKLRQPLNFILVNLCVADLLMIMFGFTTTFYTAMNGYFVFGPTGCNIEGFFATLG 1
>ENCEPH2_Ano SAVTLFFIGFFGFFLNLFVIALMCKDMQLWTPMNIILFNLVCSDFSVSIIGNPLTLTSAISHRWIFGRTLCVAYGFFMSLL GITSITTLTVLS YERYCLIS--RPFSSRNLTRRG AFLAIFFIWGYSFALTSPPLFGWG
2 GEVSLWSLVMLAIERYIVVCKPMGNFRFATTHAALGVVFTWVMASACAVPPLVGWSR 2
>CILL2_Platy AIYLCIVGVIGTLSNGVIMYLYFKDKSLRSPMNLLFVNLAMSDFTVAFFGAMFQFGLTCTRKYMSPGMALCDFYGFITFLG GLASEMNLFIIS VERYLAVV--RPFDVGNLTNRR VIAGGVFVWLYSLVFAGGPLVGWS
1 YIPEGMQCSCGPDYYTLNPKYYNESYVIYLFLVHFLLPVTIIFFTYGRLICTVKE 0
>CILL1_Platy AAYLFFIACLGVSLNVLVLVLFIKDRKLRSPNNFLYVSLALGDLLVAVFGTAFKFIITARKTLLREEDGFCKWYGFITYLG GLAALMTLSVIA FVR CLAV-LRLGSFTGLTTRM GVAAMAFIWIYSLAFTLAPLLGWN
0 AAAQQQESASTQKAEREVTRMVIIMVVGFLVCWVPYASFAFYLFMNKGILFSATAMTVPAFFSKSSVLYNPIIYVLLNKQ 0
>MEL1_homSap LGTVILLVGLTGMLGNLTVIYTFCRSRSLRTPANMFIINLAVSDFLMSFTQAPVFFTSSLYKQWLFGETGCEFYAFCGALF GISSMITLTAIA LDRYLVIT-RPLATFGVASKRR AAFVLLGVWLYALAWSLPPFFGWS
0 FRTCMVTTLFCGKNPFGEDDSSMVSTSKTEVSSVSSSQVSPS* 0
>MEL1_smiCra IGATILVVGFTGVLGNLLVIYTFCRSRSLRTPANMFIINLAISDFFMSFTQAPVFFASSLYERWIFGEKGCEFYAFCGALF GITSMITLMVIA LDRYFVIT-RPLASIGMISKKK TGLILLGVWLYSLAWSLPPFFGWS
>MEL1_galGal IGTVILIVGITGTLGNFLVIYAFCRSRTLQKPANIFIINLAVSDFLMSITQSPVFFTNSLHKRWIFGEKGCELYAFCGALF GITSMITLMVIA LDRYFVIT-KPLASVRVMSKKK ALIILVGVWLYSLAWSLPPFFGWS
>SWS2_ornAna Ornithorhynchus anatinus (platypus) Deut.Prot.Mono ABN43074 17339011 full Gt syn(-IRAK1 -MECP2 - +TKTL1) blue tandem with MWS1
>MEL1_xenTro VGAVILAVGITGMLGNFLVIYAFCRSRSLRSPANMFIINLAITDFLMSVTQAPVFFATSLHKRWIFGEKGCELYAFCGALF GITSMITLMVIA VDRYFVIT-RPLTSIGVMSKKR AVLILSGVWLYSLAWSLPPFFGWS
0 MHKTHRNLQNELPEDFFIPLPLDTDNITSLSPFLVPQTHLGGSGIFMSLAAFMFLLITLGFPINLLTVICTIKYKKLRSHLNYILVNLAVSNMLVVCVGSATAFYSFAHMYFVLGPTACKIEGFAATLG 1
>MEL1a_Bran VGTAVFCIGCCGMFGNAVVVYSFIKSKGLRTPANFFIINLALSDFLMNLTNMPIFAVNSAFQRWLLSDFACELYGFAGGLF GCLSINTLMAIS MDRYLVIT-KPFLVMRIVTKQR VMFAILLLWIWSLVWALPPLFGWS
2 GMVSLWSLAVIAFERFLVICKPLGNLSFRGTHAIFGCAATWVFGLAASLPPLFGWSR 2
>MEL2_anoCar VGSCVLVIGCIGITGNLLVLYAFYSNKRLRTPPNYFIMNLAVSDFLMSATQAPICFLNSMHKEWVLGDIGCNLYAFCGALF GITSMITLLAIS VDRYCVIT-KPLQSIKRTSKKR TCIIIVFVWLYSLGWSVCPLFGWS
1 YIPEGLQCSCGPDWYTTNNKWNNESYVIFLFSFCFGVPLSIIIFSYGRLLLTLRA 0
>MEL2_xenLae IGSFILIIGSVGIIGNMLVLYAFYRNKKLRTAPNYFIINLAISDFLMSATQAPVCFLSSLHREWILGDIGCNVYAFCGALF GITSMMTLLAIS INRYIVIT-KPLQSIQWSSKKR TSQIIVLVWMYSLMWSLAPLLGWS
0 VAKQQEQSATTQKAEREVTKMVIVMVLGFLVCWLPYASFSLWVVTNRGQVFDLRMASIPSVFSKASTIYNPIIYVFMNKQ 0
>NEUR_homSap AGFYLTIIGILSTFGNGYVLYMSSRRKKKLRPAEIMTINLAVCDLGISVVGKPFTIISCFCHRWVFGWIGCRWYGWAGFFF GCGSLITMTAVS LDRYLKIC--YLSYGVWLKRKH AYICLAAIWAYASFWTTMPLVGLG
0 FRSCMLKLVFCGKSPFGDEDEISGSSQATQVSSVSSSQVSPA* 0
>RGR_homSap VLLVEALSGLSLNTLTIFSFCKTPELRTPCHLLVLSLALADSGISLNALVAATSSLLRVSHRRWPYGSDGCQAHGFQGFVT ALASICSSAAIA WGRYHHYC-----TRSQLAWNS AVSLVLFVWLSSAFWAALPLLGWG
>PER_homSap VATYLIMAGMISIISNIIVLGIFIKYKELRTPTNAIIINLAVTDIGVSSIGYPMSAASDLYGSWKFGYAGCQVYAGLNIFF GMASIGLLTVVA VDRYLTIC--LPDVGRRMTTNT YIGLILGAWINGLFWALMPIIGWA
>SWS2_galGal Gallus gallus (chicken) Deut.Saur.Arch NP_990848 7975342 full Gt
>PERa_Branc  VGLYLFVIGIIGTIENGITLATFSKFRSLRSPTTMLLVHLAIADLGICIFGYPFSGASSLRSHWLFGGVGCQWYGFNGMFF  
0 MHPPRPTTDLPEDFYIPMALDAPNITALSPFLVPQTHLGSPGLFRAMAAFMFLLIALGVPINTLTIFCTARFRKLRSHLNYILVNLALANLLVILVGSTTACYSFSQMYFALGPTACKIEGFAATLG 1
 
2 GMVSLWSLAVVAFERFLVICKPLGNFTFRGSHAVLGCVATWVLGFVASAPPLFGWSR 2
>PPIN2_cioSa LCVFMSFVFVLAVPLNLLVIVATYKNKVLRRPINYIIVNLAVADLTCSVVGGLLGVLNNGAGYYFLGKSVCIFEGYVMSVT  
1 YIPEGLQCSCGPDWYTTDNKWHNESYVLFLFTFCFGVPLAIIVFSYGRLLITLRA 0
>MEL_Platy                                                                                    GIFGLMSINTLA WIAIDRFYVITNPLGAAQTMTKKRAFIILTIIWANASLWALAPFFGWG
0 VARQQEQSATTQKADREVTKMVVVMVLGFLVCWAPYTAFALWVVTHRGRSFEVGLASIPSVFSKSSTVYNPVIYVLMNKQ 0
>MEL1b_Bran IFGSMMLVFGLIGVVGNVVALYAFCRTRSLRRPKNYVVANLCLTDMFVCLVYCPIVVSRSFSHGFPSKESCIVEGFMVGVG -
0 FRSCMLKLLFCGRSPFGDDEDVSGSSQATQVSSVSSSHVAPA* 0
>MEL2_galGal CFVNSLHREWILGDIGCDLYAFCGALFGITSMMTLLAISVDRYLVITKPLRSIQWTSKKRTIQIIAAVWLYSLGWS
 
>SWS2_taeGut Taeniopygia guttata (finch) Deut.Saur.Arch genomic full Gt
amino terminal alignment of imaging opsins:
0 MPKPREMRDELPEDFYIPMSLETPNLTALSPFLVPQTHLGSPGIFKAMAAFMFLLVLLGVPINALTVLCTAKYKKLRSHLNYILVNLAVANLLVVCVGSTTAFYSFSQMYFALGPLACKIEGFTATLG 1
((((RHO1,RHO2), SWS1),(LWS,SWS2),(PIN,VAOP)
2 GMVSLWSLAVVAFERFLVICKPLGNFTFRGSHAVLGCAITWIFGLIASLPPLFGWSR 2
                                    !!!    ***  !!!    ** ***  * * *
1 YIPEGLQCSCGPDWYTTDNKWNNESYVIFLFCFCFGFPLTVIVFSYGRLLLTLRA 0
>RHO1_homSap                        MNGTEGPNFYVPFSNATGVVRSPFEYPQY-YLAEPWQFSM LAAYMFLLIVLGFPINFLTLYVTVQHKKLRTPLNYILLNLAVADLFMVLGGFTSTLYTSLHGYFVFGPTGCNLEGFFATLG
0 VAKQQEQSASTQKAEREVTKMVVVMVLGFLVCWLPYCSFALWVVTHRGHPFDLGLASIPSVFSKASTVYNPIIYVFMNKQ 0
>RHO1_monDom                        MNGTEGPNFYVPFSNKTGTVRSPFEEPQY-YLADPWQFSC LAAYMFMLIVLGFPINFLTLYVTIQHKKLRTPLNYILLNLAIADLFMVFGGFTMTLYTSLHGYFVFGPTGCNLEGFFATLG
0 FRSCMLKLVFCGRSPFGDEDDVSGSSQATQVSSVSSSQVSPA* 0
>RHO1_ornAna                        MNGTEGQDFYIPMSNKTGVVRSPFEYPQY-YLAEPWQYSV LAAYMFMLIMLGFPINFLTLYVTIQHKKLRTPLNYILLNLAFANHFMVLGGFTTTLYTSLHGYFVFGPTGCNIEGFFATLG
>RHO1_galGal                        MNGTEGQDFYVPMSNKTGVVRSPFEYPQY-YLAEPWKFSA LAAYMFMLILLGFPVNFLTLYVTIQHKKLRTPLNYILLNLVVADLFMVFGGFTTTMYTSMNGYFVFGVTGCYIEGFFATLG
>SWS2_anoCar Anolis carolinensis (lizard) Deut.Saur.Lepi genomic full G?
>RHO1_anoCar                        MNGTEGQNFYVPMSNKTGVVRNPFEYPQY-YLADPWQFSA LAAYMFLLILLGFPINFLTLFVTIQHKKLRTPLNYILLNLAVANLFMVLMGFTTTMYTSMNGYFIFGTVGCNIEGFFATLG
0 MQKSRPDSRDNLPEDFFIPVPLDVANITTLSPFLVPQTHLGNPSLFMGMAAFMFILIVLGVPINVLTIFCTFKYKKLRSHLNYILVNLSVSNLLVVCVGSTTAFYSFSNMYFSLGPTACKIEGFSATLG 1
>RHO1_xenTro                        MNGTEGPNFYIPMSNKTGVVRSPFDYPQY-YLAEPWKYSA LAAYMFLLILLGFPINFMTLYVTIQHKKLRTPLNYILLNLVFANHFMVLCGFTVTMYTSMHGYFIFGQTGCYIEGFFATLG
2 GMVSLWSLAVVAFERYLVICKPLGNFTFRGTHAIIGCAVTWMFGLAASLPPLFGWSR 2
>RHO1_danRer                        MNGTEGPAFYVPMSNATGVVRSPYEYPQY-YLVAPWAYGF VAAYMFFLIITGFPVNFLTLYVTIEHKKLRTPLNYILLNLAIADLFMVFGGFTTTMYTSLHGYFVFGRLGCNLEGFFATLG
1 YIPEGLQCSCGPDWYTTENKWNNESYVIFLFCFCFGVPLSVIIFSYGRLLLTLRA 0
>RHO1_Raja                          MNGTEGENFYVPMSNKTGVVRSPFDYPQY-YLGEPWMFSA LAAYMFFLILTGLPVNFLTLFVTIQHKKLRQPLNYILLNLAVSDLFMVFGGFTTTIITSMNGYFIFGPAGCNFEGFFATLG
0 VAKQQEQSATTQKAEREVTKMVVVMVMGFLVCWLPYASFALWVVTHRGEPFDVRLASIPSVFSKASTVYNPVIYVLMNKQ 0
>RHO1_lamp1                        MNGTEGENFYIPFSNKTGLARSPFEYPQY-YLAEPWKYSV LAAYMFFLILVGFPVNFLTLFVTVQHKKLRTPLNYILLNLAVANLFMVLFGFTLTMYSSMNGYFVFGPTMCNFEGFFATLG
0 FRSCMLKLIFCGKSPFGDEDDVSGSSQATQVSSVSSSQVSPA* 0
>RHO1_lamp2                        MNGTEGQNFYIPFSNKTDVARSPFEYPQY-YLAEPWKFSA LAAYMFFLILVGFPVNFLTLFVTVQHKKLRTPLNYILLNLAVSNLFMILFGFTTTMYTSMNGYFVFGPTMCSIEGFFATLG
>RHO1_lamp3                        MNGTEGDNFYVPFSNKTGLARSPYEYPQY-YLAEPWKYSA LAAYMFFLILVGFPVNFLTLFVTVQHKKLRTPLNYILLNLAMANLFMVLFGFTVTMYTSMNGYFVFGPTMCSIEGFFATLG share second glyco, 2aa insert
>SWS2_utaSta Uta stansburiana (lizard) Deut.Saur.Lepi DQ100326 16543463 full Gt
>RHO2_galGal                        MNGTEGINFYVPMSNKTGVVRSPFEYPQY-YLAEPWKYRL VCCYIFFLISTGLPINLLTLLVTFKHKKLRQPLNYILVNLAVADLFMACFGFTVTFYTAWNGYFVFGPVGCAVEGFFATLG share second glyco, 2aa insert
0 MHNSRPHSRDDLPEDFFIPMPLDVANITTLSPFLVPQTHLGSPALFMGMAAFMFLLIILGVPINVLTIFCTFKYKKLRSHLNYILVNLAVSNLLVVCIGSTTAFYSFAQMYFSLGPTACKIEGFAATLG 1
>RHO2_anoCar                        MNGTEGINFYVPLSNKTGLVRSPFEYPQY-YLAEPWKYKV VCCYIFFLIFTGLPINILTLLVTFKHKKLRQPLNYILVNLAVADLFMACFGFTVTFYTAWNGYFIFGPIGCAIEGFFATLG
2 GMVSLWSLAVVAFERFLVICKPLGNFSFRGTHAIIGCIITWVFGLVASLPPLFGWSR 2
>RHO2_Gekko                        MNGTEGINFYVPLSNKTGLVRSPFEYPQY-YLADPWKFKV LSFYMFFLIAAGMPLNGLTLFVTFQHKKLRQPLNYILVNLAAANLVTVCCGFTVTFYASWYAYFVFGPIGCAIEGFFATIG
1 YIPEGLQCSCGPDWYTTNNKWNNESYVLFLFSFCFGVPLSVIIFSYGRLLLTLRA 0
>RHO2_Lat                          MNGTEGMNFYVPLSNRTGLVRSPFEYTQY-YLAEPWKFSV LCAYMFLLIILGFPINFLTLLVTFKHKKLRQPLNYILVNLAVASLFMVVFGFTVTFYSSLNGYFVLGPMGCAMEGFFATLG
0 VAKQQEQSATTQKAEREVTKMVVVMVMGFLVCWLPYASFALWVVTHRGEPFDVRLATIPSVFSKASSVYNPVIYVFMNKQ 0
>RHO2_Geo                          MNGTEGANFYIPFHNRTGVVRSPYEYPQY-YLADPWMYSA ISAYVFTLILIGFPVNFMTLFVTFKLKKLRQPLNFILVNLCVADLLMIMFGFTTTFYTAMNGYFVFGPTGCNIEGFFATLG
0 FRSCMLKLVFCGKSPFGDEDDVSGSSQTTQVSSVSSSQVSPA* 0
>SWS1_homSap                      MRKMS-EEEFYL-FKNIS--SVGPWDGPQY-HIAPVWAFYL QAAFMGTVFLIGFPLNAMVLVATLRYKKLRQPLNYILVNVSFGGFLLCIFSVFPVFVASCNGYFVFGRHVCALEGFLGTVA 2aa indel is above
>SWS1_macDom                          MSGDEEFYL-FKNIS--SVGPWDGPQY-HIAPAWAFHF QTVFMGFVFCAGTPLNAVVLVATLRYKKLRQPLNYILVNVSLCGFIFCIFAVFTVFISSSQGYFIFGRHVCAMEAFLGSVA
>SWS2_xenTro Xenopus tropicalis (frog) Deut.Amph.Anur genomic full Gt syn(-IRAK1 -MECP2 -)
>SWS1_galGal                          MSSDDDFYL-FTNGS--VPGPWDGPQY-HIAPPWAFYL QTAFMGIVFAVGTPLNAVVLWVTVRYKRLRQPLNYILVNISASGFVSCVLSVFVVFVASARGYFVFGKRVCELEAFVGTHG
0 MSKGRPDLRMEMPDEFYVPIPLETTNISSLSPFLVPQTHLGTPGIFMSISAFMLFTIIFGFPLNLLTIICTVKYKKLRSHLNYILVNLAVANLIVICFGSTTAFYSFSQMYFSLGTLACKIEGFTATLG 1
>SWS1_Taeniop                        MD-EEEFYL-FKNQS--SVGPWDGPQY-HIAPMWAFYL QTIFMGLVFVAGTPLNAIVLIVTIKYKKLRQPLNYILVNISVSGLMCCVFCIFTVFIASSQGYFVFGKHMCAFEGFAGATG
2 GIIGLWSLAVVAFERFLVICKPMGNFTFRESHAVLGCILTWVIGLVAAIPPLLGWSR 2
>SWS1_Gekko                          MSGEEDFYL-YANIS--SVGPFDGPQY-HIAPMWAFYF QTAFMGFVFFVGTPLNAIILFAIVKYKKLRQPLNYILVNISAAGFLFCVVAVFTVFISSSQGYFIFGKHICALEAFLGSLA
1 YIPEGLQCSCGPDWYTVNNKWNNESYVLFLFCFCFGFPLAIIVFSYGRLLLALHA 0
>SWS1_Utasta                          MSGEEDFYL-FENIS--SVGPWDGPQY-HIAPMWAFYF QTAFMGFVFFAGTPLNAIILIVTVKYKKLRQPLNYILVNISFAGFLFCVFSVFTVFLASSQGYFFFGRHICALEAFLGSVA
0 VAKQQEQSATTQKAEREVTRMVIVMVVGFLVCWLPYASFALWAVTHRGELFDLRMSSVPSVFSKASTVYNPFIYIFMNRQ 0
>SWS1_Xenopus                        MLEEEDFYL-FKNVS--NVSPFDGPQY-HIAPKWAFTL QAIFMGMVFLIGTPLNFIVLLVTIKYKKLRQPLNYILVNITVGGFLMCIFSIFPVFVSSSQGYFFFGRIACSIDAFVGTLT
0 FRSCMMKMIFCGKNPLGDDEETSVSGSTQVSSVSSSQIAPS* 0
>SWS1_Danio                          MD--AWAVQ-FGNAS--KVSPFEGEQY-HIAPKWAFYL QAAFMGFVFIVGTPMNGIVLFVTMKYKKLRQPLNYILVNISLAGFIFDTFSVSQVSVCAARGYYSLGYTLCSMEAAMGSIA
>SWS1_Oryzias                        MG--KYFYL-YENIS--KVGPYDGPQY-YLAPTWAFYL QAAFMGFVFFVGTPLNFVVLLATAKYKKLRVPLNYILVNITFAGFIFVTFSVSQVFLASVRGYYFFGQTLCALEAAVGAVA
>SWS2_neoFor Neoceratodus forsteri (lungfish) Deut.Sarc.Dipn EF526299 17961206 full Gt
>SWS1_Geotri                          MSGDEEFYL-FKNIS--KVGPWDGPQF-HIAPKWAFYL QAAFMGFVFICGTPLNAIVLVVTIKYKKLRQPLNYILVNISAAGLVFCLFSISTVFVASMQGYFFLGPTICALEAFFGSLA
0 MHRTKPDPQEDLPDDFYIPVSLNTNNITMLSPFLVPQTHLGSPSVFMVLSVFMFFLLITGIPINVLTIICTFKYKKLRSHLNYILVNLAVANLIVVGFGSTTAFYSFSQMYFAWGPLACKIEGFAATLG 1
>SWS2_ornAna            MHKTHRNLQNELPEDFFIPLPLDTDNIT--SLSPFLVPQT-HLGGSGIFMS LAAFMFLLITLGFPINLLTVICTIKYKKLRSHLNYILVNLAVSNMLVVCVGSATAFYSFAHMYFVLGPTACKIEGFAATLG
2 GMVSLWSLAVVAFERFLVICKPLGNFTFRSTHAIIGCVATWVFGLISSAPPLFGWSR 2
>SWS2_galGal            MH--PPRPTTDLPEDFYIPMALDAPNIT--ALSPFLVPQT-HLGSPGLFRA MAAFMFLLIALGVPINTLTIFCTARFRKLRSHLNYILVNLALANLLVILVGSTTACYSFSQMYFALGPTACKIEGFAATLG
1 YIPEGLQCSCGPDWYTTNNKWNNESYVIFLFCFCFGFPLSVIIFSYGRLLMTLRA 0
>SWS2_Taenio              MPKPREMRDELPEDFYIPMSLETPNLT--ALSPFLVPQT-HLGSPGIFKA MAAFMFLLVLLGVPINALTVLCTAKYKKLRSHLNYILVNLAVANLLVVCVGSTTAFYSFSQMYFALGPLACKIEGFTATLG
0 VAKQQEQSASTQKAEREVTKMVVVMVLGFLVCWLPYTVFSLWVVTHRGESFELALGSIPAVFSKSSTVYNPLIYVFMNKQ 0
>SWS2_Utasta            MHNSRPHSRDDLPEDFFIPMPLDVANIT--TLSPFLVPQT-HLGSPALFMG MAAFMFLLIILGVPINVLTIFCTFKYKKLRSHLNYILVNLAVSNLLVVCIGSTTAFYSFAQMYFSLGPTACKIEGFAATLG
0 FRSCMMKLIFCGKSPFGDEDDASSASQSTQVSSVSSSQVAPA* 0
>SWS2_Xenopu            MSKGRPDLRMEMPDEFYVPIPLETTNIS--SLSPFLVPQT-HLGTPGIFMS ISAFMLFTIIFGFPLNLLTIICTVKYKKLRSHLNYILVNLAVANLIVICFGSTTAFYSFSQMYFSLGTLACKIEGFTATLG
>SWS2_Danio                MKQQQQTPELFEDFHMPITLDVSNIS--AYSPFLVPQD-HLGHSGVFMG MSAFMLFLFIAGTAINVLTIVCTIQYKKLRSHLNYILVNLAISNLWVSVFGSSVAFYAFYKKYFVFGPIGCKIEGFTSTIG
>SWS2_tetNig Tetraodon nigroviridis (pufferfish) Deut.Acti.Perc genomic full G?
>SWS2_Takifu                MRGVRQHEFQEDFYIPIPLDVDNIT--ALSPFLVPQD-HLGSPAVFYG MSAFMFFLFVAGTGINVLTIACTIQYKKLRSHLNYILVNLAFSNLLVTTVGSFTCFCCFFVRYMIVGPLGCKIEGFAATLG
0 MRGNRQHEFQEDFFIPIPLEVDNITALSPFLVPQDHLGSPALFYGMAAFMFCLFVSGTGINALTIACTVKYKKLRSHLNYILVNLAVSNLLVTCVGSFTCFCCFTVRYMFVGPLGCKIEGFAATLG 1
>SWS2_Geotri            MYQGKSTQVDDLPEDFYIPIALNVKNMS--ELSPFLVPQV-HLGDSFIFYG MSAFMLFLVLAGFPLNFLTVFVTIKYKKLRSHLNYILVNLAIANLIVVCCGSTLAFYSFMHKYFILGPLFCKMEGFTATLG
2 GMVSLWSLAVVAFERWLVVCKPLGNFIFKPDHAIACCAATWLFALVVSGPPLFGWSR 2
>LWS_ornAna      MTPAWNSGVYAARRRFEDEEDTTRTSVFVYTNSNNT---RDPFEGPNY-HIAPRWAYNV TSLWMIFVVIASVFTNGLVLVATMKFKKLRHPLNWILVNLAVADLGETLIASTISVINQIFGYFILGHPMCVLEGYTVSLC 1 aa indel
1 YIPEGFQCSCGPDWYTTGNKYNNESYVMFIFGFGFAVPFFVIVFCYSQLLFVLKS 0
>LWS_galGal      MAAWEA--AFAARRR-HEEEDTTRDSVFTYTNSNNT---RGPFEGPNY-HIAPRWVYNL TSLWMIFVVAASVFTNGLVLVATWKFKKLRHPLNWILVNLAVADLGETVIASTISVINQISGYFILGHPMCVVEGYTVSAC
0 AQAESASTQKAEKEVTRMVVVMIFGFLVCWLPYASFALWAVNNRGTPFDLRLATIPACFSKSSAVYNPVIYVVLNKQ 0
>LWS_anoCar MAGTVTEAWDVAVFAARRR-NDEDDTTRDSLFTYTNSNNT---RGPFEGPNY-HIAPRWVYNI TSVWMIFVVIASIFTNGLVLVATAKFKKLRHPLNWILVNLAIADLGETVIASTISVINQISGYFILGHPMCVLEGYTVSTC
0 FRSCMKKMLGMSGGDDEDSSASQSVTEVSKVSPS* 0
>LWS_Lithoch    MAEEWGKQSFAARRY---HEDSTRGSAFAYTNSNNT---RDPFEGPNY-HIAPRWIYNL ATLWMFVVVVLSVFTNGLVLVATMKFKKLRHPLNWILVNLAIADLGETVFASTISVCNQFFGYFILGHPMCIFEGYVVSVC
>LWS_Gastero    MAEEWGKQAFAARRY---NEDTTRGSMFVYTNSNNT---KDPFEGPNY-HIAPRWVYNL STLWMFIVVALSVFTNGLVLVATAKFKKLQHPLNWILVNLAIADLGETVFASTISVCNQFFGYFILGHPMCVFEGYVVSVC
>SWS2_takRub Takifugu rubripes (fugu) Deut.Acti.Perc genomic full Gt
>LWS_Petrom      MTASWQGAMFAARRR-QDDEDTTMESLFRYTNENNT---KDPFEGPNY-HIAPRWVFNL TSVWMIIVVVLSLFSNGLVLVATVKFKKLRHPLNWIIVNLAIADILETIFASTISVCNQVYGYFILGHPMCVFEGYVVSTC
0 MRGVRQHEFQEDFYIPIPLDVDNITALSPFLVPQDHLGSPAVFYGMSAFMFFLFVAGTGINVLTIACTIQYKKLRSHLNYILVNLAFSNLLVTTVGSFTCFCCFFVRYMIVGPLGCKIEGFAATLG 1
>LWS_lamprey    MTASWHGAVFAARRR-NDDEDTTKDSIFRYTNENNT---RDPFEGPNY-HIAPRWMFNL TSVWMIIVVVLSLFTNGLVLVATMKFKKLRHPLNWILVNLAIADILETIFASTISVCNQVFGYFILGHPMCVFEGYVVSTC
2 GMVSLWSLAVVAFERWLVVCKPLGNFIFKPDHAIVCCIFTWFFALIISAPPLFGWSR 2
>LWS_Geotria    MAQSWERAMFAARRR--QDEDTTKGDLFRYTNENNT---RDPFEGPNY-HIAPRWMYNL TSFWMIIVVILSLFTNGLVLVATLKFKKLRHPLNWILVNLAIADIGETIFASTVSVVNQIFGYFILGHPLCVFEGFTVSVC
1 YIPEGFQCSCGPDWYTTGNKYNNESYVWFIFGFGFAVPLFVIVFCYSQLLVMLKS 0
>PIN_galGal                            MSSNSSQAPPNGT---PGPFDGPQWPYQAPQSTYVG VAVLMGTVVACASVVNGLVIVVSICYKKLRSPLNYILVNLAVADLLVTLCGSSVSLSNNINGFFVFGRRMCELEGFMVSLT P 1aa insert non-ancestral unless VAOP earlier
0 AKAQAESASTQKAEREVTRMVVVMILGFLVCWLPYASFALWVVNNRGTPFDLRLATIPACFSKASTVYNPIIYVVLNKQ 0
>PIN_utaSta                                MVNEWSNAT---PGPFDGPQWPYLAPRSIYTS VAVLMGLVVVSAAFVNGLVIVVSIQYKKLRSPLNYILVNLAIADLLVTSFGSTLSFANNIYGFFVLGQTACEFEGFMVSLT these opsins are very limited frog to liz/bird
0 FRSCMKKMLGMSGGDDEESSSQSVTEVSKVSPS* 0
>PIN_pheMad                        MHVQMANASQASLKNGT---LSPFDGPQWPHRASRRVYTS LAALMGVVVLSASLANGLVIAVSVRFKRLRSPLNYILVNLATADLLVTFFGSIISFVNNAVGFFVFGKTACRFEGFMVSLT
>PIN_podSic                          MQASNASWVEVRNRT---PGPFEGPQWPYLAPQSTYIS VAVLMGLVVISATLVNGLVIVVSVQFKKLRSPLNYVLVNLAVADLLVTFFGSTISFVNNAQGFFIFGQATCEFEGFMVSLT
>SWS2_gasAcu Gasterosteus aculeatus (stickleback) Deut.Acti.Perc genomic full Gt
>PIN_xenTro                              MRAGNMSAYEA---PGPYDGPQWPHLAPRSTFLT VAAVMCMVVILAFFVNGLVIVVTLKYKKLRSPLNYILVNLAIANLLVTIFGSSVSFSNNVVGYFFMGKTMCEFEGFMVSLT the glyco is either not homologous or lost in frogs
0 MKHGRVPEIPEDFYIPISLDTDNITSLSPFLVPQDHLASKATFYSLAFYMFFILIVGTFINALTVACTVQNKKLRSHLNYILVNLAVSNLLVSGVGAFTAFLSFAARYFVLGTLACKVEGFLATLG 1
>PIN_bufJap                              MHSANMSALET---PGPFEGPQWPHVAPRSTYLT VAVLMGMVVFLAFFVNGMVIVVSLKYKKLRSPLNYILVNLAVADILVTMFGSTVSFHNNIFGFFTLGKLVCELEGFVVSLT
2 GMVSLWSLAVIAFERWLVICKPLGNFIFKPDHALVCCAFTWVFALAASAPPLVGWSR 2
>VAOP_galGal                      MDVFRALGNESLLSNSSGPARWDPFHHPLD-SIQP-WHFRL VAAVMFVVTSLSLAENLAVILVTFKFKQLRQPVNYVIVNLSVADFLVSLTGGTISFLANLKGYFYMGHWACVLEGFAVTFF no consistent glyco, much older than PIN
1 YIPEGLQCSCGPDWYTTNNKYNNESYVLFLFGFCFAVPFCTICFCYSQLLFTMKMA 0
>VAOP_anoCar                        MAGLRREAENDSWLFDPSSSSAPFLQPLD-IIEP-WNFHL ISALMFVVTLFSLSENFTVILVTIKFKQLRQPLNYVIVNLSVADFLVSLIGGTISFSTNLKGYFYMGHWACVLEGFAVTFF losing all the invariant residues almost
0 AKAQAESASTQKAEREVTRMVVLMVMGFLVCWMPYASFALWVVNNRGQTFDLRFASIPSVFSKSSAVYNPVIYVLLNKQ 0
>VAOP_xenTro                            MPTNVSLLATPENSTVWNPFTGPLK-TIEA-WNFHL LAALMFVVTSLSIAENFIVILVTAKFKQLRQPLNYIIVNLSVADFLVSVIGGTISIATNSRGYFYLGSWACVLEGFAVTFF
  0 FRSCMMKMLGMGGGDDEESSTSSVTEVSKVGPA* 0
>VAOP_danRer                              MEASSAAVNAVSPAEDPFSAPLS-SIAP-WNYSV LAALMFVVTALSLSENFTVMLVTFRFQQLRQPLNYIIVNLSLADFLVSLTGGSISFLTNYHGYFFLGKWACVLEGFAVTFF
   
>VAOP_rutRut                              MELFPVAVNGVSHAEDPFSGPLT-FIAP-WNYKV LATLMFVVTAASLSENFAVMLVTFRFTQLRKPLNYIIVNLSLADFLVSLTGGTISFLTNYHGYFFLGKWACVLEGFAVTYF
>SWS2_oryLat Oryzias latipes (medaka) Deut.Acti.Perc AB223056 16460888 full Gt
>VAOP_Petro              MDALQESPPSHHSLPSALPSATGGNGTVATMHNPFERPLE-GIAP-WNFTM LAALMGTITALSLGENFAVIVVTARFRQLRQPLNYVLVNLAAADLLVSAIGGSVSFFTNIKGYFFLGVHACVLEGFAVTYF
0 MRFISGGELPDDFWIPIPLDTNNLSLLSPFLVPQDHLGSSGTFYAMAAFMFFLFVFGTSINSLTIACTFQNKKLRSHLNYILVNLSVANLLVSGVGSSTAFCSFACRYFVFGSLACKIEGFAATLG 1
>PPIN_anaCar                                    MDSLDTNTLSPNASTVRVVLMPRIGYTI IAIIMATSCTLSVILNTAVIAITIKYRQLRQPINYSLVNLAIADLGAALLGGSLNVETNAVGYYNLGRVGCVTEGFAMAFF
2 GMVGLWSLAVIAFERWLVICKPLGNFTFKPEHALACCLVTWVCALAAAAPPLAGWSR 2
>PPIN_Xenop                                MADEALLPPMMNVTNEEMHPGKVLMPRIGYTI LALIMAVFCAAALFLNVTVIVVTFKYRQLRHPINYSLVNLAIADLGVTVLGGALTVETNAVGYFNLGRVGCVIEGFAVAFF
1 YIPEGLQCSCGPDWYTTNNKYNNESYVMFLFCFCFAVPFATIVFCYSQLLVTLKMA 0
>PPIN_Ictal                                MASIILINFSETDTLHLGSVNDHIMPRIGYTI LSIIMALSSTFGIILNMVVIIVTVRYKQLRQPLNYALVNLAVADLGCPVFGGLLTAVTNAMGYFSLGRVGCVLEGFAVAFF
0 AKAQAESASTQKAEREVTRMVVVMVLGFLVCWMPYASFALWVVNNRGHSFDLRLATIPSCLSKASTVYNPVIYVLLNKQ 0
>PPIN_Danio                                        MESETSTAASGSIAE-VMPRMGYTI LAVIIGVFSVCGVILNVTVITVTLKYKQLRQPLNFALVNLAVADLGCAVFGGLPTVVTNAMGYFSLGRVGCVLEGFAVAFF
  0 FRSCMLTMLGMGGGEEEDSTSVTEVSKVGPA* 0
>PPIN_Oncor                                MDHQQLLPNLHGNISSSPGSVSEALLSRTGFTI LAVIIGVFSVSGVCMNVLVIMVTMRHRKLRQPLNYALVNLAVADLGCALFGGLPTMVTNAMGYFSMGRLGCVLEGFAVAFF
   
>PPINa_Ciona                  MDHDVTPTVDLTDGVPQCKDLNPYVLKGDGWVPQHISRANRSTYSF LCVYMTFVFLLSCSLNILVIVATLKNKVLRQPLNYIIVNLAVVDLLSGFVGGFISIAANGAGYFFWGKTMCQIEGYFVSNF
  >SWS2_geoAus Geotria australis (lamprey) Deut.Agna.Hype AY366492 17463225 full Gt
>PPINb_Ciona                MTTAETTTECYEKNPYIRNEMGWVPKHILIAERHIYTILAVYMTFIFL LAVYMTFIFLLAVSLNGFVIIATMKNKKLRQPLNYIIINLSIADFLSGLVGGFIGMISNSAGYFYFGKTVCILEGYIVSVA
0 MYQGKSTQVDDLPEDFYIPIALNVKNMSELSPFLVPQVHLGDSFIFYGMSAFMLFLVLAGFPLNFLTVFVTIKYKKLRSHLNYILVNLAIANLIVVCCGSTLAFYSFMHKYFILGPLFCKMEGFTATLG 1
>PPIN2_cioSa                              IPQNYSNGNPYATTDSGWVPEHIEIANRSTYSG LCVFMSFVFVLAVPLNLLVIVATYKNKVLRRPINYIIVNLAVADLTCSVVGGLLGVLNNGAGYYFLGKSVCIFEGYVMSVT
2 GMLSLWSLAVLAFERCLVICKPFGNIAFRGTHALIRCGFAWAAAIAASTPPLFGWSR 2
>PPIN_lamp                                        MENLTSLDLLPNGEVPLMPRYGFTI LAVIMAVFTIASLVLNSTVVIVTLRHRQLRHPLNFSLVNLAVADLGVTVFGASLVVETNAVGYFNLGRVGCVIEGFAVAFF
1 YIPEGLQCSCGPDWYTTNNKYNNESYVMFLFIFCFGTPFTIIIVSYSKLILTLRA 0
>PARIE_Utast      ME-NDSSLATEL--------------------AEGAIVKPTIFPKAG-------YGV LAFLMFLNALFSIFNNSLVIAVTLKNPQLRNPINIFILNLSFSDLMMSLCGTTIVIATNYYGYFYLGRKFCIFQGFAVNYF
0 AAAQQQESASTQKAEKEVSRMVVIMVGGFLVCWLPYASLALWIVFNRGSPFDLRLATIPSVFSKASTVYNPVIYIFLNKQ 0
>PARIE_Anole      ME--NESSLVLE--------------------AEGYIVRPTIFPRAG-------YGV LAFLMFINALFSLFNNFLVIAVTLKNPQLRNPINIFILNLSFSDLMMSICGTTIVIATNYHGYFYLGRRFCIFQGFAVNYF
0 FRSCMMKTIFCGKNPLGDDEDATSTTTQVSSVSTSQVAPA* 0
>PARIE_Xenop      MD-GNSTTPGI---------------------AVNLTVMPTIFPRSG-------YSI LSFLMFLNAVFSICNNAIVILVTLKHPQLRNPINIFILNLSFSDLMMALCGTTIVVSTNYHGYFYLGKQFCIFQGFAVNYF
>ENCEPH_braBe      EY-GNNTTFAAWDFKRNGTGGEEEVEF-----------------FG-------YDA VAGVIAIIGVVGFVSNGAVVVLFLKFPQLRTPFNLLLLNMAVADLLVSVCGNTLSFASAVRHRWLWGRPGCVWYGFANHLF
>SWS1_homSap Homo sapiens (human) Deut.Euth.Euar NM_001708 1385866 full Gt OPN1SW syn(-FAM137A +SWS1 -CALU -NAG6 -FLNC)
>ENCEPH_homS      MYSGNRS--------GGHGYWDGGGAAGAEG------PAPAGTLSPAPLFSPGTYER LALLLGSIGLLGVGNNLLVLVLYYKFQRLRTPTHLLLVNISLSDLLVSLFGVTFTFVSCLRNGWVWDTVGCVWDGFSGSLF
0 MRKMSEEEFYLFKNISSVGPWDGPQYHIAPVWAFYLQAAFMGTVFLIGFPLNAMVLVATLRYKKLRQPLNYILVNVSFGGFLLCIFSVFPVFVASCNGYFVFGRHVCALEGFLGTVA 1
>ENCEPH_monD      MYSDNSS------DDGGGGYWGSGRAGGASGTGVTGEPGPEGSPRQAPLFSPGTYEL LALLIATIGLLGLCNNLLVLVLYYKFQRLRTPTHLFLVNISFNDLLVSLFGVTFTFVSCLRSGWVWDSVGCAWDGFSNTLF
2 GLVTGWSLAFLAFERYIVICKPFGNFRFSSKHALTVVLATWTIGIGVSIPPFFGWSR 2
>ENCEPH_galG      MHSGNGT---------------------GATSRPQLAAAGHEVPGERPLFSAGTYEL LALLIATIGTLGVCNNLLVLVLYYKFKRLRTPTNLFLVNISLSDLLVSVCGVSLTFMSCLRSRWVWDAAGCVWDGFSNSLF
1 FIPEGLQCSCGPDWYTVGTKYRSESYTWFLFIFCFIVPLSLICFSYTQLLRALKA 0
>ENCEPH_anoC      MFSANGT---------RSGAGSDLEPGPGQQQQQREASEEEERGAGLSPFSAGTYEL LALLVAAIGLLGLCNNLLVLVLYAKFKRLRTPTHLFLVNISLSDLLVSLFGVSFTFGSCLRHRWVWDAAGCVWDGFSNSLF
0 VAAQQQESATTQKAEREVSRMVVVMVGSFCVCYVPYAAFAMYMVNNRNHGLDLRLVTIPSFFSKSACIYNPIIYCFMNKQ 0
>ENCEPH_xenT      MPVTNGS-----------------------------HNNSISWLHSKDMFTEDTYHF LALIVATVGFLGLVNNLLVLILYCKFKRLQTPTNLLFFNTSLCHFVFSLLAITFTFMSCVRGSWAFSVEMCVFHGFSKNLL
  0 FQACIMKMVCGKAMTDESDTCSSQKTEVSTVSSTQVGPN* 0
>ENCEPH_braB      MPLYNTSSGPTQGLPWDTPYSQDPIWNDSSPSNSSEDAVVDQGRGELQDFSDAGYTA IATGLALIGLVGSMNNFVVILLIGCHRQLRTPFNLLLLNVSVADLLVSVCGNTLSFASAVQHRWLWGRPGCVWYGFANSLF
   
>ENCEPH_braF      MALYNNTSSPSQDLLWDAPYSQGHIW-DNSSASNSSEDVMDQGKVELQDFSDAGYTA IATCLALIGFVGFTNNFVVILLIGCHRQLRTPFNLLLLNMSVADLLVSVCGNTLSFASAVRHRWLWGRPGCVWYGFANSLF
>SWS1_monDom Monodelphis domesticus (opossum) Deut.Meta.Dide genomic full Gt OPN1SW syn(-FAM137A +SWS1 -CALU -NAG6 -FLNC)
>ENCEPH2_Api                                              MEHVIYEDQVSPVMYIGA AIALGFIGFFGFTANLLVAIVIVKDAQILWTPVNVILFNLVFGDFLVSIFGNPVAMVSAATGGWYWGYKMCLWYAWFMSTL
  0 MSGDEEFYLFKNISSVGPWDGPQYHIAPAWAFHFQTVFMGFVFCAGTPLNAVVLVATLRYKKLRQPLNYILVNVSLCGFIFCIFAVFTVFISSSQGYFIFGRHVCAMEAFLGSVA 1
>ENCEPH1_Ano                                      MYDVTDAAAINSDHQELMAPWAYNGA AVTLFFIGFFGFFLNIFVIALMYKDVQ-LWTPMNIILFNLVCSDFSVSIIGNPLTLTSAISHRWLYGKSICVAYGFFMSLL
2 GLVTGWSLAFLAFERFIVICKPFGNFRFNSKHAMMVVLATWVIGIGVSIPPFFGWSR 2
>ENCEPH2_Ano                                    MNDAPNDVAASAVDYEDLMAPWAYNAS AVTLFFIGFFGFFLNLFVIALMCKDMQ-LWTPMNIILFNLVCSDFSVSIIGNPLTLTSAISHRWIFGRTLCVAYGFFMSLL
1 FIPEGLQCSCGPDWYTVGTKYRSEYYTWFLFIFCFIMPLFLICFSYSQLLRALRA 0
>CILL2_Platyr                        MDDLGFLGNSSVNYTVPLLQEDPLLLRILYFGPTSYVIT AIYLCIVGVIGTLSNGVIMYLYFKDKSLRSPMNLLFVNLAMSDFTVAFFGAMFQFGLTCTRKYMSPGMALCDFYGFITFLG
0 VAAQQQESATTQKAEREVSRMVVMMVGSFCLCYVPYAALAMYMVNNQNHGLDLRLVTIPAFFSKSACVYNPIIYCFMNKQ 0
>CILL1_Platyr            MDGENLTIPNPVTELMDTPINSTYFQNLNAETDGGNHYIYNAFTATDYNIC AAYLFFIACLGVSLNVLVLVLFIKDRKLRSPNNFLYVSLALGDLLVAVFGTAFKFIITARKTLLREEDGFCKWYGFITYLG
0 FHACIMEMVCRKPMTDDSDVSSSQKTEVSAVSSSQVGPT* 0
                                    !!!    ***  !!!    ** ***  * * *
>RHO1_homSap                        MNGTEGPNFYVPFSNATGVVRSPFEYPQY-YLAEPWQFSM LAAYMFLLIVLGFPINFLTLYVTVQHKKLRTPLNYILLNLAVADLFMVLGGFTSTLYTSLHGYFVFGPTGCNLEGFFATLG
>SWS1_smiCra Sminthopsis crassicaudata (dunnart) Deut.Meta.Dasy AY442173 full G? OPN1SW
 
  0 MSGDEEFYLFKNISLVGPWDGPQYHLAPAWAFHFQTAFMGFVFFAGTSLNGVVLIATLRYKKLRQPLNYILVNISLAGFIFCVFSVFTVFVSSSQGYFVFGRHVCAMEGFLGSVA 1
 
  2 GLVTGWSLAFLAFERFIVICKPFGNFRFNSKHAMMVVLATWIIGIGVSIPPFFGWSR 2
Here's the distal alignment of the opsins and a blurb on how the gene classifier can be used:
  1 YIPEGLQCSCGPDWYTVGTKYRSEYYTWFLFIFCFIVPLSLICFSYSQLLGALRA 0
 
  0 VAAQQQESATTQKAEREVSRMVVVMVGSFCLCYVPYAAMAMYMVNNRNHGLDLRLVTIPAFFSKSACVYNPIIYCFMNKQ 0
>RHO1_homSap  RYIPEGLQCSCGIDYYTLKPEVNNESFVIYMFVVHFTIPMIIIFFCYGQLVFTVKE AAAQQQESATTQKAEK----EVTRMVIIMVIAFLICWVPYASVAFYIFTHQGSNFGPIFMTIPAFFAKSAAIYNPVIYIMMNKQ FRNCMLTTIC CGKNPLG DDEASATVS KTE    TSQVAPA
  0 FHACIMEMICKKPMTDDSETTSSQKTEVSTVSSSQVGPS* 0
>RHO1_monDom  RYIPEGMQCSCGIDYYTLKPEVNNESFVIYMFVVHFTIPLIVIFFCYGQLVFTVKE AAAQQQESATTQKAEK----EVTRMVIIMVIAFLICWLPYAGVAFYIFTHQGSNFGPIFMTIPAFFAKSSSVYNPVIYIMMNKQ FRTCMITTLC CGKNPLG DDEASATAS KTE    TSQVAPA
   
>RHO1_ornAna  RYIPEGMQCSCGIDYYTLRPEVNNESFVIYMFVVHFTIPMTIIFFCYGRLVFTVKE AAAQQQESATTQKAEK----EVTRMVIIMVIAFLICWVPYASVAFYIFTHQGSNFGPIFMTVPAFFAKSSAIYNPVIYIMMNKQ FRNCMLTTIC CGKNPLG DDEASATAS KTEQSSVSTSQVSPA
>SWS1_tarRos Tarsipes rostratus (honey_possum) Deut.Meta.Dipr AY772472 18426754 full G? OPN1SW
>RHO1_galGal  RYIPEGMQCSCGIDYYTLKPEINNESFVIYMFVVHFMIPLAVIFFCYGNLVCTVKE AAAQQQESATTQKAEK----EVTRMVIIMVIAFLICWVPYASVAFYIFTNQGSDFGPIFMTIPAFFAKSSAIYNPVIYIVMNKQ FRNCMITTLC CGKNPLG DEDTSAG    KTETSSVSTSQVSPA
  0 MSGDEEFYLFKDISSVGPWDGPQYHIAPAWAFHFQTTFMGFVFFAGTPLNAVVLIATLRYKKLRQPLNYILVNISLAGFIFCVISVFTVFISSSQGYFIFGRHVCAMEAFLGSVA 1
>RHO1_anoCar  RYIPEGMQCSCGVDYYTPTPEVHNESFVIYMFLVHFVTPLTIIFFCYGRLVCTVKA AAAQQQESATTQKAER----EVTRMVVIMVISFLVCWVPYASVAFYIFTHQGSDFGPVFMTIPAFFAKSSAIYNPVIYILMNKQ FRNCMIMTLC CGKNPLG DEDTSAGT  KTETSTVSTSQVSPA
  2 GLVTGWSLAFLAFERFIVICKPFGNFRFSSKHAMMVVLATWVIGIGVSIPPFFGWSR 2
>RHO1_xenTro  RYIPEGMQCSCGVDYYTLKPEVNNESFVVYMFIVHFTIPLCVIFFCYGRLLCTVKE AAAQQQESATTQKAEK----EVTRMVVMMVIFFLICWVPYAYVAFYIFTHQGSDFGPVFMTVPAFFAKSSAIYNPVIYIVLNKQ FRNCLITTLC CGKNPFG DEEGSSAASS KTEASSVSSSQVSPA
1 YIPEGLQCSCGPDWYTVGTKYHSEYYTGFLFIFCFIVPLSLICFSYSQLLGALRA 0
>RHO1_danRer  RYIPEGMQCSCGVDYYTRTPGVNNESFVIYMFIVHFFIPLIVIFFCYGRLVCTVKE AARQQQESETTQRAER----EVTRMVIIMVIAFLICWLPYAGVAWYIFTHQGSEFGPVFMTLPAFFAKTSAVYNPCIYICMNKQ FRHCMITTLC CGKNPFE EEEGASTTAS KTEASSVSSSSVSPA
  0 VAAQQQESATTQKAEREVSRMVVVMVGSFCLCYVPYAALAMYMVNNRNHGLDLRLVTIPAFFSKSACVYNPIVYWFMNKQ 0
>RHO1_Raja    RYIPEGLQCSCGVDYYTMKPEVNNESFVIYMFVVHFTIPLIVIFFCYGRLVCTVKE AAAQQQESESTQRAER----EVTRMVIIMVVAFLICWVPYASVAFYIFINQGCDFTPFFMTVPAFFAKSSAVYNPLIYILMNKQ FRNCMITTIC LGKNPFE EEESTSASAS KTEASSVSSSQVAPA
  0 FHACIMEMVCRKPMTDDSEISSSQKTEVSTVSSSQVGPS* 0
>RHO1_lamprey1 RYLPEGMQCSCGPDYYTLNPNFNNESFVIYMFLVHFIIPFIVIFFCYGRLLCTVKE AAAAQQESASTQKAEK----EVTRMVVLMVIGFLVCWVPYASVAFYIFTHQGSDFGATFMTVPAFFAKTSALYNPIIYILMNKQ FRNCMITTLC CGKNPLG DEDSGASTS KTEVSSVSTSQVSPA
>RHO1_lamprey2 RYLPEGMQCSCGPDYYTMNPTYNNESFVIYMFIVHFTIPFVIIFFSYGRLLCTVKE AAAAQQESASTQKAEK----EVTRMVVLMVVGFLVCWVPYASVAFYIFTNQGSDFGATFMTLPAFFAKSSALYNPVIYILMNKQ FRNCMITTLC CGKNPLG DDDSGASTS KTEVSSVSTSQVAPA
>SWS1_galGal Gallus gallus (chicken) Deut.Saur.Arch genomic full Gt OPN1SW violet
>RHO1_lamprey3 RYIPEGMQCSCGPDYYTLNPNFNNESYVVYMFVVHFLVPFVIIFFCYGRLLCTVKE AAAAQQESASTQKAEK----EVTRMVVLMVIGFLVCWVPYASVAFYIFTHQGSDFGATFMTLPAFFAKSSALYNPVIYILMNKQ FRNCMITTLC CGKNPLG DDESGASTS KTEVSSVSTSQVSPA
0 MSSDDDFYLFTNGSVPGPWDGPQYHIAPPWAFYLQTAFMGIVFAVGTPLNAVVLWVTVRYKRLRQPLNYILVNISASGFVSCVLSVFVVFVASARGYFVFGKRVCELEAFVGTHG 1
>RHO2_galGal  RYMPEGMQCSCGPDYYTHNPDYHNESYVLYMFVIHFIIPVVVIFFSYGRLICKVRE AAAQQQESATTQKAEK----EVTRMVILMVLGFMLAWTPYAVVAFWIFTNKGADFTATLMAVPAFFSKSSSLYNPIIYVLMNKQ FRNCMITTIC CGKNPFG DEDVSSTVSQSKTEVSSVSSSQVSPA
2 GLVTGWSLAFLAFERYIVICKPFGNFRFSSRHALLVVVATWLIGVGVGLPPFFGWSR 2
>RHO2_anoCar  RYIPEGMQCSCGPDYYTLNPDYHNESYVLYMFGVHFVIPVVVIFFSYGRLICKVRE AAAQQQESASTQKAER----EVTRMVILMVLGFLLAWTPYAMVAFWIFTNKGVDFSATLMSVPAFFSKSSSLYNPIIYVLMNKQ FRNCMITTIC CGKNPFG DEDVSSSVSQSKTEVSSVSSSQVSPA
1 YMPEGLQCSCGPDWYTVGTKYRSEYYTWFLFIFCFIVPLSLIIFSYSQLLSALRA 0
>RHO2_Gekko    RFIPEGMQCSCGPDYYTLNPDFHNESYVIYMFIVHFTVPMVVIFFSYGRLVCKVRE AAAQQQESATTQKAEK----EVTRMVILMVLGFLLAWTPYAATAIWIFTNRGAAFSVTFMTIPAFFSKSSSIYNPIIYVLLNKQ FRNCMVTTIC CGKNPFG DEDVSSSVSQSKTEVSSVSSSQVAPA
0 VAAQQQESATTQKAEREVSRMVVVMVGSFCLCYVPYAALAMYMVNNRDHGLDLRLVTIPAFFSKSACVYNPIIYCFMNKQ 0
>RHO2_Latime  RYIPEGLQCSCGPDYYTLNPDFHNESYVMYLFLVHFLLPIIIIFFTYGRLICKVKE AAAQQQESASTQKAEK----EVTRMVILMVIGFLTAWVPYASAAFWIFCNRGAEFTATLMTVPAFFSKSSCLFNPIIYVLLNKQ FRNCMITTLC CGKNPLG DDDTSSAVSQSKTDVSSVSSSQVSPA
0 FRACIMETVCGKPLTDDSDASTSAQRTEVSSVSSSQVGPT* 0
>RHO2_Geot    RYIPEGMQCSCGPDYYTLNPKYYNESYVIYLFLVHFLLPVTIIFFTYGRLICTVKE AAAQQQESASTQKAER----EVTRMVIIMVVGFLVCWVPYASFAFYLFMNKGILFSATAMTVPAFFSKSSVLYNPIIYVLLNKQ FRTCMVTTLF CGKNPFG EDDSSMVSTS KTEVSSVSSSQVSPS
>SWS1_homSap  RFIPEGLQCSCGPDWYTVGTKYRSESYTWFLFIFCFIVPLSLICFSYTQLLRALKA VAAQQQESATTQKAER----EVSRMVVVMVGSFCVCYVPYAAFAMYMVNNRNHGLDLRLVTIPSFFSKSACIYNPIIYCFMNKQ FQACIMKMV CGKAMTDESDTCSSQ    KTEVSTVSSTQVGPN
  >SWS1_taeGut Taeniopygia guttata (finch) Deut.Saur.Arch genomic full Gt OPN1SW
>SWS1_macDom  RFIPEGLQCSCGPDWYTVGTKYRSEYYTWFLFIFCFIMPLFLICFSYSQLLRALRA VAAQQQESATTQKAER----EVSRMVVMMVGSFCLCYVPYAALAMYMVNNQNHGLDLRLVTIPAFFSKSACVYNPIIYCFMNKQ FHACIMEMV CRKPMTDDSDVSSSQ    KTEVSAVSSSQVGPT
0 MDEEEFYLFKNQSSVGPWDGPQYHIAPMWAFYLQTIFMGLVFVAGTPLNAIVLIVTIKYKKLRQPLNYILVNISVSGLMCCVFCIFTVFIASSQGYFVFGKHMCAFEGFAGATG 1
>SWS1_galGal  RYMPEGLQCSCGPDWYTVGTKYRSEYYTWFLFIFCFIVPLSLIIFSYSQLLSALRA VAAQQQESATTQKAER----EVSRMVVVMVGSFCLCYVPYAALAMYMVNNRDHGLDLRLVTIPAFFSKSACVYNPIIYCFMNKQ FRACIMETV CGKPLTDDSDASTSAQ  RTEVSSVSSSQVGPT
  2 GLVTGWSLAFLAFERYIVICKPFGNFRFNSRHALLVVAATWIIGVGVAIPPFFGWSR 2
>SWS1_Taeni    RYIPEGLQCSCGPDWYTVGTKYKSEYYTWFLFIFCFIVPLSLIIFSYSQLLSALRA VAAQQQESATTQKAER----EVSRMVVVMVGSFCMCYVPYAALAMYMVNNREHGIDLRLVTIPAFFSKSSCVYNPIIYCFMNKQ FRACIMETV CGRPMTDDSEVSSSAQ  RTEVSSVSSSQVGPS
1 YIPEGLQCSCGPDWYTVGTKYKSEYYTWFLFIFCFIVPLSLIIFSYSQLLSALRA 0
>SWS1_Gekko    RFIPEGLQCSCGPDWYTVGTKYYSEYYTWFLFVLCFIVPLSIIVFSYSQLLSALRA VAAQQQESATTQKAER----EVSRMVVVMVGSFCLCYVPYAALAMYMVNNRNHGIDLRMVTIPAFFSKSSCVYNPIIYCFMNKQ FRGCILEMV CGKTMAEESEVSSASQ  KTEVSSVSSSQVGPS
0 VAAQQQESATTQKAEREVSRMVVVMVGSFCMCYVPYAALAMYMVNNREHGIDLRLVTIPAFFSKSSCVYNPIIYCFMNKQ 0
>SWS1_Uta      RFIPEGLQCSCGPDWYTVGTKYKSEYYTWFLFIFCFIVPLTLIIFSYSQLLGALRA VAAQQQESATTQKAER----EVSRMVVVMVGSFCLCYVPYAALAMYMVNNRDHGIDLRLVTIPAFFSKSACVYNPIIYCFMNKQ FRACIMETV CGKPMTDESDVSSSAQ  KTEVSSVSSSQVSPS
0 FRACIMETVCGRPMTDDSEVSSSAQRTEVSSVSSSQVGPS* 0
>SWS1_Xenop    RYMPEGLQCSCGPDWYTVGTKYRSEYYTWFIFIFCFVIPLSLICFSYGRLLGALRA VAAQQQESASTQKAER----EVSRMVIFMVGSFCLCYVPYAAMAMYMVTNRNHGLDLRLVTIPAFFSKSSCVYNPIIYSFMNKQ FRGCIMETV CGRPMSDDSSVSSTSQ  RTEVSTVSSSQVSPA
>SWS1_Danio    RYIPEGLGCSCGPDWYTNCEEFSCASYSKFLLVTCFICPITIIIFSYSQLLGALRA VAAQQAESASTQKAEK----EVSRMIIVMVASFVTCYGPYALTAQYYAYSQDENKDYRLVTIPAFFSKSSCVYNPLIYAFMNKQ FNACIMETV FGKKIDESSEVSS      KTETSSVSA
>SWS1_anoCar Anolis carolinensis (lizard) Deut.Saur.Lepi genomic full Gt OPN1SW syn(+SWS1 -CALU)
>SWS1_Oryzia  RYIPEGLQCSCGPDWYTVGTKYKSEYYTYFLFVFCFVVPLSIIIFSYGSLLGTLRA VAAQQQESASTQKAER----EVSRMVIMMVASFCTCYVPYAALAVYMVTNRDHNIDLRFVTVPAFFSKASCVYNPLIYSFMNKQ FNGCIMEMV FGKKMEEASEVSS      KTEVSTDS
0 MSGQEDFYLFENISSVGPWDGPQYHIAPMWAFYFQTAFMGFVFFAGTPLNAIILIVTVKYKKLRQPLNYILVNISFAGFLFCTFSVFTVFMASSQGYFFFGRHVCAMEAFLGSVA 1
>SWS1_Geotri  RYIPEGLQCSCGPDWYTVGTKYKSEYYTYFLFVFCFVVPLSIIIFSYGSLLGTLRA VAAQQQESASTQKAER----EVSRMVIMMVASFCTCYVPYAALAVYMVTNRDHNIDLRFVTVPAFFSKASCVYNPLIYSFMNKQ FRACILETV CGKPITDESETSSS    RTEVSSVSTTQMIPG
2 GLVTGWSLAFLAFERYIVICKPFGNFRFNSRHALLVVAATWIIGVGVAIPPFFGWSR 2
>SWS2_ornAna  RYIPEGLQCSCGPDWYTTNNKWNNESYVIFLFSFCFGVPLSIIIFSYGRLLLTLRA VAKQQEQSATTQKAER----EVTKMVIVMVLGFLVCWLPYASFSLWVVTNRGQVFDLRMASIPSVFSKASTIYNPIIYVFMNKQ FRSCMLKLVF CGKSPFGDEDEISGSS  QATQVSSVSSSQVSPA
1 YIPEGLQCSCGPDWYTVGTKYKSEYYTWFLFIFCFIVPLTLIIFSYSQLLGALRA 0
>SWS2_galGal  RYIPEGLQCSCGPDWYTTDNKWHNESYVLFLFTFCFGVPLAIIVFSYGRLLITLRA VARQQEQSATTQKADR----EVTKMVVVMVLGFLVCWAPYTAFALWVVTHRGRSFEVGLASIPSVFSKSSTVYNPVIYVLMNKQ FRSCMLKLLF CGRSPFGDDEDVSGSS  QATQVSSVSSSHVAPA
0 VAAQQQESATTQKAEREVSRMVVVMVGSFCLCYVPYASLAMYMVNNRDHGLDLRLVTIPAFFSKSSCVYNPIIYCFMNKQ 0
>SWS2_Taeni    RYIPEGLQCSCGPDWYTTDNKWNNESYVIFLFCFCFGFPLTVIVFSYGRLLLTLRA VAKQQEQSASTQKAER----EVTKMVVVMVLGFLVCWLPYCSFALWVVTHRGHPFDLGLASIPSVFSKASTVYNPIIYVFMNKQ FRSCMLKLVF CGRSPFGDEDDVSGSS  QATQVSSVSSSQVSPA
0 FRACILETVCGKPMSDESDVSSSAQKTEVSSVSSSQVSPS* 0
>SWS2_Uta      RYIPEGLQCSCGPDWYTTNNKWNNESYVLFLFSFCFGVPLSVIIFSYGRLLLTLRA VAKQQEQSATTQKAER----EVTKMVVVMVMGFLVCWLPYASFALWVVTHRGEPFDVRLATIPSVFSKASSVYNPVIYVFMNKQ FRSCMLKLVF CGKSPFGDEDDVSGSS  QTTQVSSVSSSQVSPA
   
>SWS2_Xeno    RYIPEGLQCSCGPDWYTVNNKWNNESYVLFLFCFCFGFPLAIIVFSYGRLLLALHA VAKQQEQSATTQKAER----EVTRMVIVMVVGFLVCWLPYASFALWAVTHRGELFDLRMSSVPSVFSKASTVYNPFIYIFMNRQ FRSCMMKMIF CGKNPLGDDEETSVSG    STQVSSVSSSQIAPS
>SWS1_utaSta Uta stansburiana (lizard) Deut.Saur.Lepi DQ100325 16543463 full Gt OPN1SW
>SWS2_Danio    RYIPEGLQCSCGPDWYTTNNKFNNESYVMFLFCFCFAVPFSTIVFCYGQLLITLKL AAKAQADSASTQKAER----EVTKMVVVMVFGFLICWGPYAIFAIWVVSNRGAPFDLRLATIPSCLCKASTVYNPVIYVLMNKQ FRSCMMKMVF NKNIEEDEASSSS      QVTQVSSVAPEK
0 MSGEEDFYLFENISSVGPWDGPQYHIAPMWAFYFQTAFMGFVFFAGTPLNAIILIVTVKYKKLRQPLNYILVNISFAGFLFCVFSVFTVFLASSQGYFFFGRHICALEAFLGSVA 1
>SWS2_Takif    RYIPEGFQCSCGPDWYTTGNKYNNESYVWFIFGFGFAVPLFVIVFCYSQLLVMLKS AAKAQAESASTQKAER----EVTRMVVVMILGFLVCWLPYASFALWVVNNRGTPFDLRLATIPACFSKASTVYNPIIYVVLNKQ FRSCMKKMLG MSGGDDEESSS          QSVTEVSKVSPS
2 GLVTGWSLAFLAFERYIVICKPFGNFRFNSKHALLVVAATWFIGIGVSIPPFFGWSR 2
>SWS2_Geotria RYIPEGLQCSCGPDWYTTNNKYNNESYVMFLFIFCFGTPFTIIIVSYSKLILTLRA AAAQQQESASTQKAEK----EVSRMVVIMVGGFLVCWLPYASLALWIVFNRGSPFDLRLATIPSVFSKASTVYNPVIYIFLNKQ FRSCMMKTIF CGKNPLGDDEDATSTTT    QVSSVSTSQVAPA
  1 FIPEGLQCSCGPDWYTVGTKYKSEYYTWFLFIFCFIVPLTLIIFSYSQLLGALRA 0
>LWS_ornAna    RYWPHGLKTSCGPDVFSGSSDPGVQSYMIVLMSTCCILPLSIIVLCYLQVWLAIRA VAKQQKESESTQKAEK----EVSRMVVVMILAYCFCWGPYTIFACFAAANPGYAFHPLAAALPAYFAKSATIYNPIIYVFMNRQ FRNCIMQL  FGKKVDDGSELSSTS    RTEVSSVSS VSPA
0 VAAQQQESATTQKAEREVSRMVVVMVGSFCLCYVPYAALAMYMVNNRDHGIDLRLVTIPAFFSKSACVYNPIIYCFMNKQ 0
>LWS_galGal    RYWPHGLKTSCGPDVFSGSSDPGVQSYMVVLMVTCCFFPLAIIILCYLQVSLAIRA VAAQQKESESTQKAEK----EVSRMVVVMIVAYCFCWGPYTFFACFAAANPGYAFHPLAAALPAYFAKSATIYNPIIYVFMNRQ FRNCILQL  FGKKVDDGSEVSTS    RTEVSSVSNSSVSPA
0 FRACIMETVCGKPMTDESDVSSSAQKTEVSSVSSSQVSPS* 0
>LWS_anoCar    RYWPHGLKTSCGPDVFSGSDDPGVLSYMIVLMITCCFIPLAVILLCYLQVWLAIRA VAAQQKESESTQKAEK----EVSRMVVVMIIAYCFCWGPYTVFACFAAANPGYAFHPLAAALPAYFAKSATIYNPIIYVFMNRQ FRNCIMQL  FGKKVDDGSELSSTS    RTEVSSVSNSSVSPA
>LWS_Lithoch  RYWPHGLKTSCGPDVFSGSEDPGVQSYMIVLMLTCCIFPLAIIILCYLAVWMAIRA VAMQQKESESTQKAER----EVSRMVVVMIVAYCVCWGPYTFFACFAAANPGYAFHPLAAAMPAYFAKSATIYNPIIYVFMNRQ FRTCIMQL  FGKQVDDGSEVSTS    KTEV    SSVAPA
>SWS1_xenLae Xenopus laevis (frog) Deut.Amph.Anur genomic full Gt OPN1SW syn(+SWS1 -CALU)
>LWS_Gastero  RYWPHGLKTSCGPDVFSGSEDPGVQSYMIVLMITCCLIPLAIIILCYLAVWLAIRA VAMQQKESESTQKAER----DVSRMVVVMIVAYIVCWGPYTTFACFAAANPGYAFHPLAAAMPAYFAKSATIYNPVIYVFMNRQ FRSCIMQL  FGKEVDDGSEVSTs    KTEV    SSVAPA
0 MLEEEDFYLFKNVSNVSPFDGPQYHIAPKWAFTLQAIFMGMVFLIGTPLNFIVLLVTIKYKKLRQPLNYILVNITVGGFLMCIFSIFPVFVSSSQGYFFFGRIACSIDAFVGTLT 1
>LWS_Petromy  RYWPHGLKTSCGPDVFSGSTDPGVQSYMVVLMITCCFLPLSIIILCYLQVWLAIHS VAQQQKESETTQKAER----DVSRMVVVMILAYVFCWGPYTFFACFAAANPGYSFHPIAAALPAYFAKGATIYNPIIYVFMNRQ FRNCILQL  FGKKVDDGSEVSSSS    RTEVSSVSNSSVSPA
2 GLVTGWSLAFLAFERYIVICKPMGNFNFSSSHALAVVICTWIIGIVVSVPPFLGWSR 2
>LWS_lamprey  RYWPHGLKTSCGPDVFSGSSDPGVQSYMVVLMVTCCFLPLSVIILCYLQVWLAIHS VAQQQKESETTQKAER----DVSRMVVVMILAYIFCWGPYTFFACYAAANPGYAFHPLTAALPAYFAKSATIYNPVIYVFMNRQ FRNCIMQL  FGKKVDDGSEVSSAS    RTEVSSVSNSSISPA
1 YMPEGLQCSCGPDWYTVGTKYRSEYYTWFIFIFCFVIPLSLICFSYGRLLGALRA 0
>LWS_Geotria  RYWPHGLKTSCGPDVFSGSTDPGVQSYMVVLMITCCFIPLALIIICYLQVWLAIHT VAQQQKESETTQKAER----DVSRMVVVMIFAYIFCWGPYTFFACFAAANPGYAFHPLAAALPAYFAKSATIYNPIIYVFMNRQ FRNCIMQL  FGKKVDDGSEVSSSA    RTEVSSVSNSSVSPA
0 VAAQQQESASTQKAEREVSRMVIFMVGSFCLCYVPYAAMAMYMVTNRNHGLDLRLVTIPAFFSKSSCVYNPIIYSFMNKQ 0
>PIN_galGal    SYVPEGLRTSCGPNWYTGGSNNN--SYILSLFVTCFVLPLSLILFSYTNLLLTLRA AAAQQKEADTTQRAER----EVTRMVIVMVMAFLLCWLPYSTFALVVATHKGIIIQPVLASLPSYFSKTATVYNPIIYVFMNKQ FQSCLLEMLC CGYQPQRTGKASPGTPGPHADVTAAGLRNKVMPAHPV
0 FRGCIMETVCGRPMSDDSSVSSTSQRTEVSTVSSSQVSPA* 0
>PIN_Uta sta  SYVPEGLRTSCGPNWYTGGSGNN--SYIMALFVTCFALPLGMIIFSYASLLLTLRA VATQQKEVETTQQAEK----EVTRRVIAMVMAFLVCWLPYASFAMVVATNKDLVIQPALASLPSYFSKTATVYNPIIYVFMNKQ FRSCLLSTMS CGHRPRGAQETTPAMISIPQGPTSALQGSRNKVTPSA
>PIN_Phelsuma SYVPEGLGTSCGPNWYMGGTNNN--SYIVALFVTCFALPLSMILFSYANLLLTLRA VAAQQKEQETTQRAEK----EVTRMVITMVMAFLVCWLPYATFAMVVATTKDLSIQPGLASLPSYFSKTATVYNPIIYVFMNKQ FRSCLLNTVS CGRIPQTMPGTPATTAVRGGFVLTSEGRGNKVASTEL
>SWS1_neoFor Neoceratodus forsteri (lungfish) Deut.Sarc.Dipn EF526299 17961206 full Gt OPN1SW
>PIN_Podarcis  SYVPEGLRTSCGPNWYSGGSSNN--SYIMTLFVTCFAMPLSTILFSYANLLMTLRT VAAQQKEQETTQRAER----EVTRMVVAMVAAFLVCWLPYASFAMVVATHKDLAIRPALASLPSYFSKTATVYNPIIYVFMNKQ FRSCLLYKMS CGHRALSSQDTTPAGISLPGRLTTSASKGSRNQVSPS
0 MSGEEEFYLFKNISSVGPWDGPQYHIAPKWAFFLQAAFMGFVLFVGTPLNAIVLFVTIKYKKLQQPLNYILVNISLAGFIFCFFGVFAVFIASCQGYFIFGKTVCALEGFTGSVA 1
>PIN_xenTro    SYVPEGLRTSCGPNWYTGGTNNN--SYIMALFLTCFIMPLSTIIFSYSNLLMALRA VAAQQKDSETTQRAEK----EVTRMVIAMVLAFLICWLPYASFAVVVAVNKDVVIEPTVASLPSYFSKTATVYNPIIYVFMNKQ FRNCLMTLLC CGRSFGDDETSSASGRTDVTSVSEAGGNKVTPA
2 GLVTGWSLAILAFERYLVICKPIGNFRFGSKHSMIAVVAAWVIGVGVSIPPFFGWSR 2
>PIN_Bufo      SYVPEGLGTSCGPNWYTGGTNNN--SYILALFTTCFMMPLTTIIFSYSNLLLALRA VAAQQKESETTQRAER----EVTRMVIAMVLAFLICWLPYAVFAIVMASNKNVVIDPTLASMPSYFSKTATVYNPVIYVFMNKQ FRDCLTKLLC CGRNPFGEDETSTTSGRTDVTSVSEGGGNKVTPA
1 YIPEGLQCSCGPDWYTVGTKYKSEYYTWFLFIFCFIIPLFIICFSYSQLLGALRA 0
>CILL2_Platyn SYRPEGLGTWCSISWQDRSMNTM--SYVTAVFLGCYFFPVSIIIFCYFNVWRKVKE AADAQGAGTAGKAEKS-----IFRMSVIMVTCYLTAWTPYAIVCLIASYGPPNGLPIYAEVLPSLFAKSSQVYNPIIYVLMNKP
0 VAAQQQESATTQKAEREVSRMIIVMVGSFCVCYVPYAALAMYMVNNRDHGIDLRLVTIPAFFSKSSFVYNPIIYCFMNKQ 0
>ENCEPH_braBel SYQFEGHSVGCSVNWVKHNVNNV--SYIITLMVTCFFVPMVVVCWSYACIWRTVRM SAEMKSEFGNPQNTGR----LVTTMVVVMIVCFLVCWTPYTVMALIVTFGADHLVTPTASVIPSLVAKSSTAYNPIIYVLMNNQ FREFLLARLRTFCCRQPRMLRVTPMDDNAHARLVGEGPSHAQQVIPSEEN
0 FRACIMQTVFGKPMTDDSDISSSGKTEVSSVSSSQVNPS*
>ENCEPH_braFlo SYQFEGHNVGCSVNWVQHNPDNV--SYIVTLMVTCFFVPMVVVCWSYAWIWRTVRM SSEAKPECGNSQNAGR----LVTTMVVVMIICFLVCWTPYAVMALIVTFGADHLVTPTASVIPSLVAKSSTAYNPIIYVLMNNQ FREFLLARLQRVCCRQQAVPRVTPMDDNVHVRLGGEGPSQSQQFLPAGEN
>VAOP_galGal  SYTTSKIGTTCEPNWYSGAYNDR--SYIIAFFTTCFIVPLLVILVSYGKLLQKLRK VSNTQGRLRTARKPER----QVTRMVVVMIIAFLICWMPYAVFSILATAYPSIELDPHLAAIPAFFSKTATVYNPIIYVFMNKQ FRMCLIQMFK CSAIETAESNMNPTSERATLTQDKRDSQLSVMAVRST
>SWS1_danRer Danio rerio (zebrafish) Deut.Acti.Otoc genomic full Gt OPN1SW syn(-PNPLAS +IRG5 -TNPO3 +SWS1 -CALU -DYRK2)
>VAOP_anoCar  SYTTSKIGTTCEPNWYSGDYNDH--TFIITFFTTCFILPLLVILVSYGKLMRKLRK VSDTQGRLGTTRKPER----QVTGMVVIMILAFLICWSPYAAFSILVTACPSIELDPRLAAIPAFFSKTATVYNPVIYVFMNNQ FRKCLVQLFQ CSSQETMDANVNPISEKDTLTHTKHCGEMSTVAAHVI
0 MDAWAVQFGNASKVSPFEGEQYHIAPKWAFYLQAAFMGFVFIVGTPMNGIVLFVTMKYKKLRQPLNYILVNISLAGFIFDTFSVSQVSVCAARGYYSLGYTLCSMEAAMGSIA 1
>VAOP_xenTro  SYTTSKIGTTCEPNWYSGEMRDH--TYIITFLTTCFVFPLLVIFMSYGKLMRKLRK VSDTQGRLGSTRKPEK----EVTRMVVIMILAFLICWTPYAAFSILITAHPTIDLDPRLAAIPAFFAKTASMYNPIIYVYMNKQ FRRCLYQMFN INDPEAKESNLNPTSERGVLTRNNNGGEMLAIATHIT
2 GLVTGWSLAVLAFERYVVICKPFGSFKFGQGQAVGAVVFTWIIGTACATPPFFGWSR 2
>VAOP_Danio    SYTVSRIGTTCEPNWYSGNFHDH--TFIITLFSTCFIFPLGVIIVCYCKLIRKLRK VSNTHGRLGNARKPER----QVTRMVVVMIVAFMVAWTPYAAFSIIITAHPSMHVDPRLAAIPAFVAKTAAVYNPIIYVFMNKQ FRKCLVQLLS CSKVTVVEGNNNQTTERAGMTSGSNTGEMSAIAARVS
1 YIPEGLGTACGPDWYTKSEEYNSESYTYFLLITCFMMPMTIIIFSYSQLLGALRA 0
>VAOP_Ruti    SYTVSKIGTTCEPNWYSGNFHDH--TFIIAFFITCFILPLGVIVVCYCKLIKKLRK VSNTHGRLGNARKPER----QVTRMVVVMIVAFMVAWTPYAAFSIVVTAHPSIHLDPRLAAAPAFFSKTAAVYNPVIYVFMNKQ FRKCLVQLLR CRDVTIIEGNINQTSERQGMTNESHTGEMSTIASRIP
0 VAAQQAESESTQKAEREVSRMVVVMVGSFVLCYAPYAVTAMYFANSDEPNKDYRLVAIPAFFSKSSSVYNPLIYAFMNKQ 0
>VAOP_Petrom  SYRPSMIGTTCEPNWYSGELHDH--TFILMFFSTCFIFPLAVIFFSYGKLIQKLKK ASETQRGLESTRRAEQ----QVTRMVVVMILAFLVCWMPYATFSIVVTACPTIHLDPLLAAVPAFFSKTATVYNPVIYIFMNKQ FRDCFVQVLP CKGLKKVSATQTAGAQDTEHTASVNTQSPGNRHNIAL
  0 FNACIMETVFGKKIDESSEVSSKTETSSVSA* 0
>PPIN_anaCar  GYQMEGVMTSCAPDWANSDPINV--SYIICYFLFCFTIPFITILASYGYLIWTLRQ VAKVGLAQRGSTTKAEA---QVSRMVIVMVMAFLICWLPYATFALVVVGNPQIYINPIIATIPMYMAKSSTFYNPIIYIFMNKQ FRDCLVRCLL CGRNPCASEQTDEDDLEVSTIAPAPSSRRGKVAPV
>PPIN_Xeno    SYELEGVMTSCAPNWYSADPVNM--SYIVCYFSFCFAIPFLIIVGSYGYLMWTLRQ VAKLGVAEGGTTSKAEV---QVSRMVIVMILAFLVCWLPYAAFAMTVVANPGMHIDPIIATVPMYLTKTSTVYNPIIYIFMNKQ FQECVIPFLF CGRNPWAAEKSSSMETSISVTSGTPTKRGQVAPA
>SWS1_gasAcu Gasterosteus aculeatus (stickleback) Deut.Acti.Perc DW624108 full G? OPN1SW syn(ARF4 +IRG5 -TNPO3 +SWS1) BT028514 brain transcript
>PPIN_Icta    SYQLEGVMTSCAPNWYRRDPVNV--SYILCYFMLCFALPFATIIFSYMHLLHTLWQ VAKLQVADSGSTAKVEV---QVARMVVIMVMAFLLTWLPYAAFALTVIIDSNIYINPVIGTIPAYLAKSSTVFNPIIYIFMNRQ FRDYALPCLL CGKNPWAAKEGRDSDTNTLTTTVSKNTSVSPL
0 MGKHFHLYENISKVDPFEGPQYYLAPMWAFYLQTAFMGFVFFAGTPLNFTVLLVTAKYKKLRVPLNYILVNITLAGFIFVTFSVSQVFVASARGYYFLGYTLCALEAAMGSVA 1
>PPIN_Danio    RLQLEGVRTSCAPDWYSRDLANV--SFIVCYFLLCFALPFSVIVYSYTRLLWTLRQ VSRLQVCEGGSAARAEA---QVSCMVVVMILAFLLTWLPYASFALCVILIPELYIDPVIATVPMYLTKSSTVFNPIIYIFMNRQ FRDRALPFLL CGRNPWAAEAEEEEEETTVSSVSRSTSVSPA
2 GLVTAWSLAVLSFERYLIICKPFGAFKFTSNHALGAVAFTWFMGICCSSPPFFGWSR 2
>PPIN_Oncorhy SFELEGVRTSCSPNWYSREPGNM--SYIILYFLLCFAIPFSIIMVSYARILFTLHQ VSKLKVLEGNSTTRVEI---QVVRMVVVMVMAFLLSWLPYAAFALSVILDPSLHINPLIATVPMYLAKSSTVYNPIIYVFMNRQ FRDCAVPFLL CGLNPWASEPVGSEADTALSSVSKNPRVSPQs
1 YIPEGLGCSCGPDWYTHNVEFNCTSYLYFLIVTCFIMPLSIIIFSYSQLLGALRA 0
>PPIN_lamp    SYELEGVRTSCAPDWYSRDPANV--SYITSYFAFCFAIPFLVIVVAYGRLMWTLHQ VAKLGMGESGSTAKAEA---QVSRMVVVMVVAFLVCWLPYALFAMIVVTKPDVYIDPVIATLPMYLTKTSTVYNPIIYIFMNRQ FRDCAVPFLL CGRNPWAEPSSESATAASTSATSVTLASAPGQVSPS
0 VAAQQAESESTQKAEKEVSKMIIVMVGSFVACYAPYAITGLWFAFSPDENKDYRLVTVPAYFSKSSCVYNPLIYAFMNKQ 0
>PARIE_Uta    SYGPEGVQTSCSIGWEERSWSNY--SYLIVYFLSCFFIPVLIIGFSYGNVIRSLHG LNKKVEQLGGKSSPEEEF--RAVIMVLVMVVAFLICWLPYTVFALIVVFNPALNISPLAATIPTYLSKTSPVYNPIIYIFLNKQ FRDCAVEFIT CGQVVLTSPEEDISTSAIPVEGKGPCKINQVTPV
0 FNACIMETVFGKPMDESSEVSSKTEVSSVSTAS* 0
>PARIE_Anole  SYGPEGVQTSCSIGWEERSWNNY--SYLIVYFLSCFFIPVLIIGFSYGNVIRSLHG LNKKVEQLGGKSNPEEEF--RAVIMVLVMVVAFLICWLPYTLFALTVVFNPALNISPLAATIPTYLSKTSPVYNPIIYIFLNKE FRECAVEFIT CGKVVLTSPEEDISTSAISDEGIAPCKINQVTPV
>PARIE_Xenop  SYGPEGVQTSCSIGWEERSWSNY--SYIISYFLTCFIIPVGIIGFSYGSILRSLHQ LNRKIEQQGGKTNPREEK--RVVIMVLFMVLAFLICWLPYTVFALIVVINPQLYISPLAATLPTYFAKTSPVYNPIIYIFLNKQ FRTYAVQCLT CGHINLDSLEEDTESVSAQAENMLTPKTNQVAPA
>SWS1_oryLat Oryzias latipes (medaka) Deut.Acti.Perc genomic full Gt OPN1SW syn(-TNPO3 +SWS1 +SOCS2 -CRADD +ARHGAP8)
>ENCEPH_braBel SYQLEGPKIGCSVAWEEHSWSNT--SYIVVLFITCLFAPLLIIVYSYYRLWHKVKQ GSRNLPAAMRKSSQKEQ---KIAMMVIVMITCFMVCWLPYGAMALVVTFGGERLISHTAAVVPSLLAKSSTCYNPVVYFAMNSQ FRRYFQDLLC CGRRLFDVSQSVVTGNTAMPRNNSQGFRKDDSDQKQD
0 MGKYFYLYENISKVGPYDGPQYYLAPTWAFYLQAAFMGFVFFVGTPLNFVVLLATAKYKKLRVPLNYILVNITFAGFIFVTFSVSQVFLASVRGYYFFGQTLCALEAAVGAVA 1
>ENCEPH_homSap RYILDVHGLGCTVDWKSKDANDS--SFVLFLFLGCLVVPLGVIAHCYGHILYSIRM LRCVEDLQTIQVIKILKYEKKLAKMCFLMIFTFLVCWMPYIVICFLVVNGHGHLVTPTISIVSYLFAKSNTVYNPVIYVFMIRK FRRCLLQLLC FRLLKFQQPKKDRPVIRTEKQIRPIVMSQKVGDRPKKKVT
2 GLVTSWSLAVLSFERYLVICKPFGAFKFGSNHALAAVIFTWFMGVGCACPPFFGWSR 2
>ENCEPH_monDom RYTLEIHGLGCSVDWKSKDPNDS--SFVIFLFFGCLMLPVGVMAYCYGHILYAIRM LRCVEELQTIQVIKILRYEKKVAKMCFLMIAIFLFCWMPYAVICLLVANGYGSLVTPTVAIIASLFAKSSTAYNPIIYIFMSRK FRRCLLQLLC FRLLKFQQPKKDRPVIRTEKQIRPIVMSQKVGDRPKKKVT
1 YIPEGLGCSCGPDWYTNCEEFSCASYSKFLLVTCFICPITIIIFSYSQLLGALRA 0
>ENCEPH_galGal RYTLEIHGLGCSMDWKSKDPNDT--SFVLLFFLGCLVAPVVIMAYCYGHILYAVRM LRCVEDFQTSQVIKLLKYEKKVAKMCFLMISTFLICWMPYAVVSLLVTYGYSNLVTPTVAIIPSFFAKSSTAYNPVIYIFMSRK FRQCLLQLLC FRLMRFQRIMKEPSGAGNVKPIRPIVMSQKVGDRPKKKVT
0 VAAQQAESASTQKAEKEVSRMIIVMVASFVTCYGPYALTAQYYAYSQDENKDYRLVTIPAFFSKSSCVYNPLIYAFMNKQ 0
>ENCEPH_anoCar HYTLEIHGLGCSVDWQSKEPSDS--SFVLFFFLGCLAAPVGIMAYCYGHILHAIRM LRCVEDLQSIQVIKILRYEKKVAKMCFLMVTTFLICWMPYAVVSLLIAYGYGHLITPTVAIIPSFFAKSSTAYNPVIYIFMSRK FRRCLVQLFC VQFLRFKRTLKEQPAIESNKPIRPIVMSQKVGDRPKKKVT
0 FNGCIMEMVFGKKMEEASEVSSKTEVSTDS*0
>ENCEPH_xenTro LYTFETHKLDCSFEWTATDPKDT--AFVLLFFLACITLPLSIMAYCYGYILYEIQK LRSVKNIQNFQEITILDYEIKMAKMCLLMMLTFLIGWMPYTILSLLVTSGYSKFITPTITVMPSLLAIASAAYNPVIHIFTIKK FRQCLVQLLP PINFHPPINPPINNFWRLLKNLNGRLAMKKVKPVLGKGRS
   
>ENCEPH1_Anoph AYVNEAANISCSVNWESQTANAT--SYIIFLFIFGLILPLAVIIYSYINIVLEMRK NSARVGRVNRAERRVT-------SMVAVMIVAFMVAWTPYAIFALIEQFGPPELIGPGLAVLPALVAKSSICYNPIIYVGMNTQ FRAAFWRIRR SNGVAGQPDSNNTNNSNRDKESARHTAKEGL
>SWS1_petMar Petromyzon marinus (lamprey) Deut.Agna.Hype genomic pseu G? OPN1SW exonic pseudogene frameshifts stops no synteny homSap
>ENCEPH2_Anoph AYVQEAANISCSVNWESQTKNAT--TYIIFLFVFGLVVPLIVIVYSYTNIIVNMRE NSARVGRINRAEQRVT-------SMVAVMIVAFMVAWTPYAIFALIEQFGPPELIGPGLAVLPALVAKSSICYNPIIYVGMNTQ FRAAFSRVRN KGQQAAADQNTTTMQRELTKSSRDMVECSF
0 MSGDEEFYLFKNISKVGPLDGPHFHIATKWAFDFQAAFMGFVFLCGtPLNAIVLIVTVKCKKLRQPLTYMLVNISAAGLVFCLFSISTVFLFSTQGYFVFGPTVCALESLFGSMA 1
>ENCEPH2_Apis SYGPEAGNVSCSVSWEVHDPVTNSDTYIGFLFVLGLIVPVFTIVSSYAAIVLTLKK VRKRAGASGRREAKIT-------KMVALMITAFLLAWSPYAALAIAAQYFNAKPSATV-AVLPALLAKSSICYNPIIYAGLNNQ FSRFLKKIFD ARGSRTAVPDSQHTALTALNRQEQRK
2 GLVTGWSLAFLAAERYIVICKPFGNFRFGSIHSLFAFCLTWVLGLGVALPPFFGWSR 2
>CILL1_Platyn  HYIPEGLATWCSIDWLSDETSDK--SYVFAIFIFCFLVPVLIIVVSYGLIYDKVRK VAKTGGSVAKAEREVL-------RMTLLMVSLFMLAWSPYAVICMLASFGPKDLLHPVATVIPAMFAKSSTMYNPLIYVFMNKQ FRRSLKVLLG MGVEDLNSESERATGGTATNQVAAT
1 YIPeGLQCSCSPDWNTVGTKYESEYCTYFLFVFCFFVQLSIIIFSYGKLLNTLra 0
>PER_homSap    SYAPDPTGATCTINWRKNDRSFV--SYTMTVIAINFIVPLTVMFYCYYHVTLSIKH HTTSDCTESLNRDWSD--QIDVTKMSVIMICMFLVAWSPYSIVCLWASFGDPKKIPPPMAIIAPLFAKSSTFYNPCIYVVANKK FRRAMLAMFK CQTHQTMPVTSILPMDVSQNPLASGRI
0 VAVQqQESSLSSTQKAEREMSRMVIVMVGSFCTCYVAALALYVVTNRDHNIDLRFVTVPAFFSKASCVYNPLIYSFMNKQ 0
>PERa_Bran    EYALEPSGTACTINFQKNDSLYI--SYVTSCFVLGFVVPLAVMAFCYWQASCFVSK VLKGDIAGDLTFPVAAN.QNHFSKMCLAMVAAFVVAWTPYSVLFLFAAFWNPADIPAWLTLLPPLIAKSSALYNPIIYIIANRR FRNAICSMMK GQDPDVEDDEHADEHRVRSIEDNDKEIISMVNLNMTV
0 FRARIMETVCGKFITDESETSSSRTAVSSVSTSQVSPG* 0
>PERc_Bran    YTYETPMQITCSLDWNVQHPGEK--AYIAAVLVIVYVLQVLIMCFCYFNIIFKSAN LKFAALASEKTKMAAKKDTWKTSVMCLTMVVSFLIAWTPYAVSSTWDILSAE-DLPIIATILPSLFAKSSCMMNPIIYACCNTK FRQAAVKSFR KLCGMCKQKVPLSTPQVVLAMQRNTEFTSTVEPT
>NEUR_homSap  DYVPEPFGTSCTLDWWLAQASVGGQVFILNILFFCLLLPTAVIVFSYVKIIAKVKS SSKEVAHFDSRIHSSHVLEMKLTKVAMLICAGFLIAWIPYAVVSVWSAFGRPDSIPIQLSVVPTLLAKSAAMYNPIIYQVIDYK FACCQTGGLK ATKKKSLEGFRLHTVTTVRKSSAVLEIHEEWE
>SWS1_geoAus Geotria australis (lamprey) Deut.Agna.Hype AY366495 17463225 full Gt OPN1SW
>MEL_Platy    AYIPEGFQTSCTYDYLTQDMNNY--TYVLGMYLFGFIFPVAIIFFCYLGIVRAIFA HHAEMMATAKRMGAN...EIQIAKVAAMTIGTFMLSWTPYAVVGVFGMIKPHSEMFIH.AEIPVMMAKASARYNPIIYALSHPK FRAEIDKHFPWLLCCCKPKPKAQLPSSTTKGSIASKTEADTSV
0 MSGDEEFYLFKNISKVGPWDGPQFHIAPKWAFYLQAAFMGFVFICGTPLNAIVLVVTIKYKKLRQPLNYILVNISAAGLVFCLFSISTVFVASMQGYFFLGPTICALEAFFGSLA 1
>MEL1_homSap  AYVPEGLLTSCSWDYMSFTPAVR--AYTMLLCCFVFFLPLLIIIYCYIFIFRAIRE TGRALQTFGACKGNG.QSECKMAKIMLLVILLFVLSWAPYSAVALVAFAGYAHVLTPYMSSVPAVIAKASAIHNPIIYAITHPK YRVAIAQHLP CLGVLLGVSRRHSRPYPSYRSTHRSTLTSHTSNL
2 GLVTGWSLAFLAAERYIVICKPFGNFRFGSKHALVAVGLTWMLGLSVALPPFFGWSR 2
 
1 YIPEGLQCSCGPDWYTVGTKYKSEYYTYFLFVFCFVVPLSIIIFSYGSLLGTLRA 0
>PPINa_Ciona  YDTEGLGTSCAPNWFVKEKRERL--FIILYFVFCFVIPLAVIMICYGKLILTLRQ IAKESSLSGGTSPEGEVTKMVVVMVTAFVFCWLPYAAFAMYNVVNPEAQ IDYALGAAPAFFAKTATIYNPLIYIGLNRQ FRDCVVRMIF NGRNPWVDELVGSQVSSTGSQLTAVSSNKVAPA
0 VAAQQQESASTQKAEREVSRMVIMMVASFCTCYVPYAALAVYMVTNRDHNIDLRFVTVPAFFSKASCVYNPLIYSFMNKQ 0
>PPINb_Ciona  GYVPEGLGTSCAPNWFSKNKSER--IFIFVYFVFCFFIPLLVIIICYGKIVLFLKQVSLY ATRQSSASSNRQADNKVTKMVLVMISAFLICWTPYGVLSLYNAINPDKQ LDYGLGAVPVFFAKTANIYNPLIYIGLNKQ FRDGVIKMVF RGRNPWAEEMSTQQRQRSTEAGQPIVSNEV
0 FRACILETVCGKPITDESETSSSRTEVSSVSTTQMIPG* 0
>PPIN2_Ciona  SVIWHTPGLFFWNGYEPEGFGTS--CAPNWFSQQKRERIFIFAYFAFCFLTPLTIIFACYLKLILFIRKVSVSKKSMVNEADRRDFEVTRMVFVMIAAFLICWLPYGCLSMYNAIHPD FRDGVIRMLF KGRNPWLDGRNTTSSTSTRAQ
 
>LWS_homSap Homo sapiens (human) Deut.Euth.Euar NP_000504 12853434 full Gt OPN1LW long wavelength syn(-IRAK1 -MECP2 -TEX28) OPN1MW deutan
>scallop SCOP2 Patinopecten yessoensis scallop Mollusca
0 MAQQWSLQRLAGRHPQDSYEDSTQSSIFTYTNSNSTR 1
MPFPLNRTDTALVISPSEFRIIGIFISICCIIGVLGNLLIIIVFAKRRSVRRPINFFVLNLAVSDLIVALLGYPMTAASAFSNRWIFDNIGCKIYAFLCFNS
2 GPFEGPNYHIAPRWVYHLTSVWMIFVVIASVFTNGLVLAATMKFKKLRHPLNWILVNLAVADLAETVIASTISVVNQVYGYFVLGHPMCVLEGYTVSLC 1
GVISIMTHAALSFCRYIIICQYGYRKKITQTTVLRTLFSIWSFAMFWTLSPLFGWS
2 GITGLWSLAIISWERWMVVCKPFGNVRFDAKLAIVGIAFSWIWAAVWTAPPIFGWSR 2
SYVIEVVPVSCSVNWYGHGLGDVSYTISVIVAVYVFPLSIIVFSYGMILQEKVCKDSRKNGIRAQQRYTPRFIQDIEQRVTFISFLMMAAFMVAWTPYAIMSALAIGSFNVENSFAALPTLFAKASCAYNPFIYAFTNAN
1 YWPHGLKTSCGPDVFSGSSYPGVQSYMIVLMVTCCITPLSIIVLCYLQVWLAIRA 0
FRDTVVEIMAPWTTRRVGVSTLPWPQVTYYPRRRTSAVNTTDIEFPDDNIFIVNSSVNGPTVKREKIVQRNPINVRLGIKIEPRDSRAATENTFTADFSVI
0 VAKQQKESESTQKAEKEVTRMVVVMVLAFCFCWGPYAFFACFAAANPGYPFHPLMAALPAFFAKSATIYNPVIYVFMNRQ 0
 
0 FRNCILQLFGKKVDDGSELSSASKTEVSSVSSVSPA* 0
>scallop      SYVIEVVPVSCSVNWYGHGLGDV--SYTISVIVAVYVFPLSIIVFSYGMILQEKVCSKNGIRAQQRYTPRFIQDIEQRVTFISFLMMAAFMVAWTPYAIMSALAIGSFNVENSFAALPTLFAKASCAYNPFIYAFTNAN
 
>LWS_monDom Monodelphis domesticus (opossum) Deut.Meta.Dide genomic full G? OPN1LW long wavelength exon 1:4 residue insert
 
0 MTQAWDPAGFLARRRDVNEDDNDETTRSSLFVYTNSNNTR 1
 
2 GPFEGPNYHIAPRWVYNLTSLWMVFVVIASIFTNGLVLVATMKFKKLRHPLNWILVNLAVADLGETVIASTISVINQIYGYFILGHPLCVLEGYTVSLC 1
The key to timing rare genomic changes are opsin sequences from non-genomic lampreys which provide suitable probe to traces of Petromyzon maritimus, the lamprey chosen for a genome project. From traces, it can be verified that the 6 bp insert plus contemporary intron positions/phases (novel 12 upstream intron in LWS and 21 post-GWSR intron exclusively in rod/cone opsins) were already established by the time of lamprey divergence. Both rare genomic events occur between transmembrane helices TM2 and TM3, ie in extracellular loop 2. These two rare genomic changes -- in conjunction with the absence of contradictory events and conventional clustering -- provide overwelming evidence against the oft-published tree sistering pinopsin with LWS to the exclusion of other cone opsins.
2 GITGLWSLAIISWERWVVVCKPFGNVKFDAKLAMVGIIFSWVWAAVWTAPPLFGWSR 2
 
1 YWPHGLKTSCGPDVFSGSSDPGVQSYMIVLMATCCIFPLSIILLCYVQVWLAIRA 0
Despite 6 sequenced opsin mRNAs and an assembly in Branchiostoma, no rod/cone opsin can be located in it or earlier diverging deuterostomes (tunicate, amphioxus, urchin, acornworm, xenoturbella). These species may have larval eye spots and related photoreceptors but lack imaging eyes. Lamprey lack to date any opsin classifying within the PIN subtree but do contain modernly configured VAOP and PPIN, the latter in its pineal gland. Hagfish, sister group to lamprey, have imaging eyes but have not been studied; their opsins situation may be derived due to deepwater marine habitat (similarly deepwater coelocanth opsins are adapted to 420 nm). The next-diverging chondrichtyes have inadequate data -- only RHO1 from skate and fragments from Callirhyncus.
0 VAKQQKESESTQKAEKEVSRMVVVMILAYCFCWGPYTLFACFAAANPGYSFHPLTASLPAYFAKSATIYNPIIYVFMNRQ 0
 
0 FRTCILQLFGKKVDDGSEVSSTSKTEGSSVSSVAPA* 0
In summary, full-blown pentachromatic color vision and rhodopsin appeared in the stem between amphioxus and lamprey divergence nodes. The oldest known fossil lamprey, Priscomyzon, dates at 360 myr to the Devonian has a full complement of modern opsins (other than parietal). Molecular clocks place lamprey divergence at approximately 430 myr, a hundred million years after Chengjiang.
 
>LWS_macEug Macropus eugenii (wallaby) Deut.Meta.Dipr genomic full G? OPN1LW long wavelength
The fossil record is unsatisfactory here: less than 1 bilateran in 10,000 in Chengjiang and Burgess Shale fossils is even a candidate for deuterostomy. Low numbers of specimens and poor preservation conspire with career ambitions to produce grandiose claims (published in Nature under controversial editor Henry Gi) that greatly exceed the data in the analysis of Hou, discoverer of the Chinese lagerstaette. Myllokunmingia is in the best situation with 500 specimens but Haikouichthys as stem deuterostome, Metaspreggina as post-ediacaran, and Yunnanozoan are all problematic. While signs of bilaterily disposed eyes are sometimes inferred, it does not follow these were image-forming eyes. Indeed contemporary Branchiostoma and tunicate larva have an eye-spot (ocellus); the genomes contain ciliary opsins clustering to approximately ENCEPH and PPIN -- still a long long road to imaging opsins. Echinoderms and hemichordates genomes have opsins but even more remote. Sea urchin genome encodes at least six opsins, four of these cluster classify to rhabdomeric, ciliary and Go-type. Tube feet are apparently the photosensory organ in adult urchins.
0 MTQAWDPAGFLAWRRDENEETTRASLFVYTNSNNTK 1
 
2 GPFEGPNYHIAPRWVFNLTSLWMIFVVIASIFTNGLVLVATMKFKKLRHPLNWILVNLAVADLGETLIASTISVINQIYGYFILGHPMCVLEGYTVSLC 1
Meanwhile, thousands of high-quality Cambrian arthropod fossils unmistakably show stalked paired eyes. Imaging eyes of contemporary arthropods and lophotrochozoan are rhabdomeric, utilizing depolarizing Gq-type receptor, phospholipase C, phosphoinositola, diacylglycerol, and transient receptor potential TRP and TRPL channel signaling. However their genomes can also contain ciliary opsins, using hyperpolarizing Gt-type transducins and phosphodiesterase cGMP second-messaging (as well as Go-type gustducin ciliary opsins in other types of photoreceptors). Vertebrates are just the opposite, having crossed over to a ciliary opsin-based imaging system, while retaining rhabdomeric signaling in melanopsin retinal ganglion cells. Cnidarian opsins are available from Hydra and Nematostella genomes. Hydra expresses a ciliary-type opsin in ectodermal sensory nerve cells whereas Nematostella has opsins classifying between melanopsin and encephalopsin. It must not be thought that bilaterans invented imaging eyes because earlier diverging cubomedusan jellyfish Carybdea marsupialis has 4 eyestalks each with 6 photoreceptors of 4 types: simple eyespots, pigment cups, complex pigment cups with lenses, and camera-type eyes with a cornea, lens, and retina. This species needs a genome project.
2 GITGLWSLAIISWERWVVVCKPFGNVKFDAKLAMVGIVFSWVWAAVWTAPPLFGWSR 2
1 YWPHGLKTSCGPDVFSGNSDPGVQSYMIVLMSTCCILPLSVIFLCYIQVWLAIRS 2
0 VAKQQKESESTQKAEKEVSRMVVVMILAFCFCWGPYAIFACFAAANPGYAFHPLTASLPAYFAKSATIYNPIIYVFMNRQ 0
0 FRTCILQLFGKKVDDGSEVSSTSRTEVSSVSSVAPA* 0
>LWS_smiCra Sminthopsis crassicaudata (dunnart) Deut.Meta.Dasy EU232013 18426754 full G? OPN1LW long wavelength
0 MTQAWDPAGFLAWRRDENEETTRASLFVYTNSNNTK 1
  2 GPFEGPNYHIAPRWVYNLTSLWMIFVVIASVFTNGLVLVATMKFKKLRHPLNWILVNLAVADLGETIIASTISVINQIYGYFILGHPMCVLEGYTVSLC 1
2 GITGLWSLAIISWERWVVVCKPFGNVKFDAKLAMVGIVFSWVWAAVWTAPPIFGWSR 2
1 YWPHGLKTSCGPDVFSGSSDPGVQSYMIVLMSTCCILPLSIIILCYIQVWLAIRA 0
0 VAKQQKESESTQKAEKEVSRMVMVMILAFCFCWGPYALFACFAAANPGYAFHPLTASLPAYFAKSATIYNPIIYVFMNRQ 0
0 FRTCILQLFGKKVDDGSEVSSTSRTEVSSVSSVAPA* 0
>LWS_ornAna Ornithorhynchus anatinus (platypus) Deut.Prot.Mono ABN43074 17339011 full Gt OPN1LW long wavelength syn(-IRAK1 -MECP2 - -) LWS green
0 MTPAWNSGVYAARRRFEDEEDTTRTSVFVYTNSNNTR 1
2 DPFEGPNYHIAPRWAYNVTSLWMIFVVIASVFTNGLVLVATMKFKKLRHPLNWILVNLAVADLGETLIASTISVINQIFGYFILGHPMCVLEGYTVSLC 1
2 GITGLWSLSIISWERWIVVCKPFGNVKFDAKLAMVGIVFSWVWAAVWTAPPIFGWSR 2
1 YWPHGLKTSCGPDVFSGSSDPGVQSYMIVLMSTCCILPLSIIVLCYLQVWLAIRA 0
0 VAKQQKESESTQKAEKEVSRMVVVMILAYCFCWGPYTIFACFAAANPGYAFHPLAAALPAYFAKSATIYNPIIYVFMNRQ 0
0 FRNCIMQLFGKKVDDGSELSSTSRTEVSSVSSVSPA* 0
>LWS_galGal Gallus gallus (chicken) Deut.Saur.Arch NM_205438 12716987 full Gt OPN1LW iodopsin missing in assembly
0 MAAWEAAFAARRRHEEEDTTRDSVFTYTNSNNTR 1
2 GPFEGPNYHIAPRWVYNLTSLWMIFVVAASVFTNGLVLVATWKFKKLRHPLNWILVNLAVADLGETVIASTISVINQISGYFILGHPMCVVEGYTVSAC 1
2 GITALWSLAIISWERWFVVCKPFGNIKFDGKLAVAGILFSWLWSCAWTAPPIFGWSR 2
1 YWPHGLKTSCGPDVFSGSSDPGVQSYMVVLMVTCCFFPLAIIILCYLQVSLAIRA 0
0 VAAQQKESESTQKAEKEVSRMVVVMIVAYCFCWGPYTFFACFAAANPGYAFHPLAAALPAYFAKSATIYNPIIYVFMNRQ 0
0 FRNCILQLFGKKVDDGSEVSTSRTEVSSVSNSSVSPA* 0
>LWS_anoCar Anolis carolinensis (lizard) Deut.Saur.Lepi genomic full Gt OPN1LW long wavelength syn(- - -TEX28 +TKTL1)
0 MAGTVTEAWDVAVFAARRRNDEDDTTRDSLFTYTNSNNTR 1
2 GPFEGPNYHIAPRWVYNITSVWMIFVVIASIFTNGLVLVATAKFKKLRHPLNWILVNLAIADLGETVIASTISVINQISGYFILGHPMCVLEGYTVSTC 1
2 GISALWSLAVISWERWVVVCKPFGNVKFDAKLAVAGIVFSWVWSAVWTAPPVFGWSR 2
1 YWPHGLKTSCGPDVFSGSDDPGVLSYMIVLMITCCFIPLAVILLCYLQVWLAIRA 0
0 VAAQQKESESTQKAEKEVSRMVVVMIIAYCFCWGPYTVFACFAAANPGYAFHPLAAALPAYFAKSATIYNPIIYVFMNRQ 0
0 FRNCIMQLFGKKVDDGSELSSTSRTEVSSVSNSSVSPA* 0
>LWS_xenTro Xenopus tropicalis (frog) Deut.Amph.Anur genomic full Gt OPN1LW long wavelength syn(-IRAK1 -MECP2 - -)
0 MASHWNEAVFAARRRNDDDDTTRSSVFTYTNSNNTR 1
2 GPFEGPNYHIAPRWVYNISSLWMIFVVLASVFTNGLVLVATLKFKKLRHPLNWILVNMAIADLGETVIASTISVCNQIFGYFVLGHPMCILEGYTVSVC 1
2 GIAALWSLTVIAWERWFVVCKPFGNIKFDGKLAATGIIFSWVWAAGWCAPPIFGWSR 2
1 YWPHGLKTSCGPDVFSGSSDPGVQSYMLVLMITCCIIPLAIIVLCYMHVWLTIRQ 0
0 VAQQQKESESTQKAEREVSRMVVVMIIAYIFCWGPYTFFACFAAFNPGYNFHPLAAAMPAYFAKSATIYNPIIYVFMNRQ 0
0 FRNCIYQLFGKKVDDGSEVSSTSRTEVSSVSNSSVSPA* 0
>LWS_neoFor Neoceratodus forsteri (lungfish) Deut.Sarc.Dipn EF526299 17961206 full Gt OPN1LW long wavelength
0 MAEPWDAVLAARRRHQDEETTRSTIFVYTNSNNTR 1
2 GPFEGPNYHIAPRWVYNLTSLWMIFVVFASCFTNGLVLMATYKFKKLRHPLNWILVNLAIADLGETLIASTISVTNQIFGYFILGHPMCMLEGFTVATC 1
2 GITGLWSLTIIAWERWVVVCKPFGNIKFDGKWAAGGIIFSWVWSAFWCAMPLFGWSR 2
1 FWPHGLKTSCGPDVFSGEDKYGTRSFMIALMITCCIIPLGVIILCYIQVWWAIRT 0
0 VAKQQKESESTQKAEKEVSRMVVVMIFAYCFCWGPYTFMACFGAAYPGYAFHPLAAALPAYFAKSATIYNPIIYVFMNRQ 0
0 FRNCIYQLLGKKVDDGSELSSTSKTEVSSVSNSSVSPA* 0
>LWS_danRer Danio rerio (zebrafish) Deut.Acti.Otoc genomic full Gt
0 MAEHWGDAIYAARRKGDETTREAMFTYTNSNNTK 1
2 DPFEGPNYHIAPRWVYNVATVWMFFVVVASTFTNGLVLVATAKFKKLRHPLNWILVNLAIADLGETLFASTISVINQFFGYFILGHPMCIFEGYTVSVC 1
2 GIAALWSLTVISWERWVVVCKPFGNVKFDAKWASAGIIFSWVWAAAWCAPPIFGWSR 2
1 YWPHGLKTSCGPDVFSGSEDPGVQSYMVVLMITCCIIPLAIIILCYIAVYLAIHA 2
0 VAQQQKDSESTQKAEKEVSRMVVVMIFAYCFCWGPYTFFACFAAANPGYAFHPLAAAMPAYFAKSATIYNPVIYVFMNRQ 0
0 FRVCIMQLFGKKVDDGSEVSTSKTEVSSVAPA* 0
>LWS_tetNig Tetraodon nigroviridis (pufferfish) Deut.Acti.Perc genomic full G?
0 MAEEWGKQSFAARRYHEDSTRGSAFVYTNSNHTR 1
2 DPFEGPNYHIAPRWVYNLATLWMFFVVVLSVFTNGLVLVATAKFKKLRHPLNWILVNLAVADLGETLFASTISVCNQFFGYFILGHPMCIFEGYVVSVC 1
2 GIAGLWSLTIISWERWIVVCKPFGNVKFDAKWATAGIVFSWIWPICWCAPPIFGWSR 2
1 YWPHGLKTSCGPDVFSGSEDPGVQSYMIVLMITCCIIPLAIIVLCYLAVWMAIRA 2
0 VAMQQKESESTQKAEREVSRMVVVMILAYCVCWGPYTFFACFAAANPGYAFHPLAAAMPAYFAKSATIYNPIIYVFMNRQ 0
0 FRVCIMKLFGKEVDDGSEVSTSKTEVSSVAPA* 0
>LWS_takRub Takifugu rubripes (fugu) Deut.Acti.Perc genomic full Gt OPN1LW long wavelength
0 MAEEWGKQSFAARRYHEDTTRGSAFVYTNSNHTR 1
2 DPFEGPNYHIAPRWVYNVATVWMFIVVVLSVFTNGLVLVATAKFKKLRHPLNWILVNLAIADLGETVFASTISVCNQFFGYFILGHPMCVFEGYTVSTC 1
2 GIAALWSLTIISWERWVVVCKPFGNVKFDAKWATGGIVFSWVWAAVWCAPPIFGWSR 2
1 YWPHGLKTSCGPDVFSGSEDPGVQSYMIVLMITCCIIPLAIIILCYLAVWLAIRS 0
0 VAMQQKESESTQKAEKEVSRMVVVMIVAYCVCWGPYTFFACFAAANPGYAFHPLAAAMPAYFAKSATIYNPVIYVFMNRQ 0
0 FRVCIMKLFGKEVDDGSEVSTSKTEVSSVAPA* 0
>LWS_gasAcu Gasterosteus aculeatus (stickleback) Deut.Acti.Perc genomic full Gt OPN1LW long wavelength
0 MAEEWGKQAFAARRYNEDTTRGSMFVYTNSNNTK 1
2 DPFEGPNYHIAPRWVYNLSTLWMFIVVALSVFTNGLVLVATAKFKKLQHPLNWILVNLAIADLGETVFASTISVCNQFFGYFILGHPMCVFEGYVVSVC 1
2 GITALWSLTIISWERWIVVCKPFGNVKFDAKWATAGIVFSWIWSAVWCAPPIFGWSR 2
1 YWPHGLKTSCGPDVFSGSEDPGVQSYMIVLMITCCLIPLAIIILCYLAVWLAIRA 0
0 VAMQQKESESTQKAERDVSRMVVVMIVAYIVCWGPYTTFACFAAANPGYAFHPLAAAMPAYFAKSATIYNPVIYVFMNRQ 0
0 FRSCIMQLFGKEVDDGSEVSTsKTEVSSVAPA* 0
>LWS_oryLat Oryzias latipes (medaka) Deut.Acti.Perc genomic full Gt
0 MAEQWGKQVFAARRQNEDTTRGSAFTYTNSNHTR 1
2 DPFEGPNYHIAPRWVYNLATLWMFFVVVLSVFTNGLVLVATAKFKKLRHPLNWILvNLAIADLGETVFASTISVCNQFFGYFILGHPMCVFEGYVVSTC 1
2 GIAALWSLTIISWERWVVVCKPFGNVKFDAKWAIGGIVFSWVWSAVWCAPPVFGWSR 2
1 YWPHGLKTSCGPDVFSGSDDPGVQSYMIVLMITCCIIPLAIIILCYLAVWLAIRA 0
0 VAMQQKESESTQKAEREVSRMVVVMIVAYCVCWGPYTFFACFAAANPGYAFHPLAAAMPAYFAKSATIYNPVIYVFMNRQ 0
0 FRTCIMQLFGKQVDDGSEVSTSKTEVSSVAPA* 0
>LWS1_calMil Callorhinchus milii (elephantfish) Deut.Chon.Holo EF565165 19196633 full G? OPN1LW long wavelength
0 MTQSWELVAPAARRGFKYDEPTHSGIFVYTNSNQTR 1
2 GPFEGPNYHIAPRWAYNLTSVWMVGVVVASVFTNGLVLVATVRFKKLRHPLNWILVNMALADLGETVLASTVSVANQFFGYFILGHPLCVFEGFVVSLC 1
2 GITALWSLTIIAWERWVVVCKPFGNMKFDSKMAVAGIVFSWVWSAGWCLPPIFGWSR 2
1 YWPHGLKTSCGPDVFSGNEDPGVQSYMVALTLSCAVLPLLIIILCYFQVWWAIRA 0
0 VALQQKESESTQKAEKEVSRMVVVMVAAFCLCWGPYACFAMFSALNPGYAFHPLVASIPSYFAKSSTIYNPIIYVFMNRQ 0
0 FRNCILQLFGKKVDDGSELSSTSKTDVSSVSNSSVSPA* 0
>LWS2_calMil Callorhinchus milii (elephantfish) Deut.Chon.Holo EF565166 19196633 full G? OPN1LW long wavelength
0 MAEPRGSVAFAARRWNDHEGTTVGEFTYTNSNSTR 1
2 DPFEGPNYHIAPRWTYNLTSLWMVVVVILSVFTNGLVLVATWKFKKLRHPLNWILVNLAIADLGETLFASTISICNQVFGYFILGHPMCVFEGFTVSAC 1
2 GITALWSLTIIAWERWVVVCKPFGNVKFDGKWAAFGIIFSWVWSIGWCLPPVFGWSR 2
1 YWPHGLKTSCGPDVFSGSSDPGVKSYMVTLVITCAALPLTIIIVCLYQVWLAIRA 0
0 VAMQQKESESTQKAEKEVSRMVVVMIIAFCFCWGPYTSFAVFSALNPGYSFHPLMAALPAYFAKSSTIYNPIIYVFMNRQ 0
0 FRNCILQLFGKKVDDGSELSSTSKTDVSSVSNSSVSPA* 0
>LWS_petMar Petromyzon marinus (lamprey) Deut.Agna.Hype genomic full Gt OPN1LW long wavelength traces key to intron 3 position and gapping
0 MTASWQGAMFAARRRQDDEDTTMESLFRYTNENNTK 1
2 DPFEGPNYHIAPRWVFNLTSVWMIIVVVLSLFSNGLVLVATVKFKKLRHPLNWIIVNLAIADILETIFASTISVCNQVYGYFILGHPMCVFEGYVVSTC 1
2 GIAGLWSLAIISWERWMVVCKPFGNIKFDGKIATILIVFSWVWPASWCSLPIFGWSR 2
1 YWPHGLKTSCGPDVFSGSTDPGVQSYMVVLMITCCFLPLSIIILCYLQVWLAIHS 0
0 VAQQQKESETTQKAERDVSRMVVVMILAYVFCWGPYTFFACFAAANPGYSFHPIAAALPAYFAKGATIYNPIIYVFMNRQ 0
0 FRNCILQLFGKKVDDGSEVSSSSRTEVSSVSNSSVSPA* 0
>LWS_letJap Lethenteron japonicum (lamprey) Deut.Agna.Hype AB116381 15096614 full Gt OPN1LW long wavelength
0 MTASWHGAVFAARRRNDDEDTTKDSIFRYTNENNTR 1
2 DPFEGPNYHIAPRWMFNLTSVWMIIVVVLSLFTNGLVLVATMKFKKLRHPLNWILVNLAIADILETIFASTISVCNQVFGYFILGHPMCVFEGYVVSTC 1
2 GIAGLWSLAIISWERWMVVCKPFGNIKFDGKIAIILIVFSWVWPACWCSLPIFGWSR 2
1 YWPHGLKTSCGPDVFSGSSDPGVQSYMVVLMVTCCFLPLSVIILCYLQVWLAIHS 0
0 VAQQQKESETTQKAERDVSRMVVVMILAYIFCWGPYTFFACYAAANPGYAFHPLTAALPAYFAKSATIYNPVIYVFMNRQ 0
0 FRNCIMQLFGKKVDDGSEVSSASRTEVSSVSNSSISPA*
>LWS_geoAus Geotria australis (lamprey) Deut.Agna.Hype AY366491 17463225 full Gt OPN1LW long wavelength
0 MAQSWERAMFAARRRQDEDTTKGDLFRYTNENNTR 1
2 DPFEGPNYHIAPRWMYNLTSFWMIIVVILSLFTNGLVLVATLKFKKLRHPLNWILVNLAIADIGETIFASTVSVVNQIFGYFILGHPLCVFEGFTVSVC 1
2 GITALWSLAIISFERWMVVCKPFGNLKFDGKVAIVLIIFSWAWSAGWCAPPIFGWSR 2
1 YWPHGLKTSCGPDVFSGSTDPGVQSYMVVLMITCCFIPLALIIICYLQVWLAIHT 0
0 VAQQQKESETTQKAERDVSRMVVVMIFAYIFCWGPYTFFACFAAANPGYAFHPLAAALPAYFAKSATIYNPIIYVFMNRQ 0
0 FRNCIMQLFGKKVDDGSEVSSSARTEVSSVSNSSVSPA* 0
>PIN_galGal Gallus gallus (chicken) Deut.Saur.Arch genomic full Gt pinopsin pineal non-visual
0 MSSNSSQAPPNGTPGPFDGPQWPYQAPQSTYVGVAVLMGTVVACASVVNGLVIVVSICYKKLRSPLNYILVNLAVADLLVTLCGSSVSLSNNINGFFVFGRRMCELEGFMVSLT 1
2 GIVGLWSLAILALERYVVVCRPLGDFQFQRRHAVSGCAFTWGWALLWSTPPLLGWSSYVPE 1
2 GLRTSCGPNWYTGGSNNNSYILSLFVTCFVLPLSLILFSYTNLLLTLRA 0
0 AAAQQKEADTTQRAEREVTRMVIVMVMAFLLCWLPYSTFALVVATHKGIIIQPVLASLPSYFSKTATVYNPIIYVFMNKQ 0
0 FQSCLLEMLCCGYQPQRTGKASPGTPGPHADVTAAGLRNKVMPAHPV* 0
>PIN_taeGut Taeniopygia guttata (finch) Deut.Saur.Arch genomic full G? pinopsin
0 MDSTQEPPNSSTPGPFDGPQWPHQAPRATYLVVAVLMGLVVASASLLNGLVIVVSVRHKRLRSPLNYILLNLAVANLLVTLCGSSVSLSNNISGFFVFGERLCQLEGFMVSLT 1
2 GIVGLWSLAILALERYLVVCRPLGDFRFQQQHAASGCAFTWGWSLLWTTPPLLGWSSYVPE 1
2 GLRTSCGPNWYTGGSNNSSYILALFVTCFVMPLSLILFSYTNLLLTLRA 0
0 AAARQQESDTTQQAEREVTRMVVAMVVAFLTCWLPYATFALVVATHKDIVIQPALASLPSYFSKTATVYNPIIYVFMNKQ 0
0 SCLLGMLCCGHHPRGMGKTSPAAPSPQVAAEGLRNKVTPSHPV* 0
>PIN_colLiv Columba livia (pigeon) Deut.Saur.Arch CLU50598 8982090 full G? pinopsin
0 MDPTNSPQEPPHTSTPGPFDGPQWPHQAPRGMYLSVAVLMGIVVISASVVNGLVIVVSIRYKKLRSPLNYILVNLAMADLLVTLCGSSVSFSNNINGFFVFGKRLCELEGFMVSLT 1
2 GIVGLWSLAILALERYVVVCRPLGDFRFQHRHAVTGCAFTWVWSLLWTTPPLLGWSSYVPE 1
2 GLRTSCGPNWYTGGSNNNSYILTLFVTCFVMPLSLILFSYANLLMTLRA 0
0 AAAQQQESDTTQQAERQVTRMVVAMVMAFLICWLPYTTFALVVATNKDIAIQPALASLPSYFSKTATVYNPIIYVFMNKQ 0
0 FQSCLLKMLCCGHHPRGTGRTAPAAPASPTDGLRNKVTPSHPV* 0
>PIN_utaSta Uta stansburiana (lizard) Deut.Saur.Lepi DQ100321 16543463 full Gt pinopsin missing genome
0 MVNEWSNATPGPFDGPQWPYLAPRSIYTSVAVLMGLVVVSAAFVNGLVIVVSIQYKKLRSPLNYILVNLAIADLLVTSFGSTLSFANNIYGFFVLGQTACEFEGFMVSLT 1
2 GIVGLWSLAILAFERYLVICKPVGDFRFQQRHAVFGCVFTWMWSLVWTLPPLFGWSSYVPE 1
2 GLRTSCGPNWYTGGSGNNSYIMALFVTCFALPLGMIIFSYASLLLTLRA 0
0 VATQQKEVETTQQAEKEVTRRVIAMVMAFLVCWLPYASFAMVVATNKDLVIQPALASLPSYFSKTATVYNPIIYVFMNKQ 0
0 FRSCLLSTMSCGHRPRGAQETTPAMISIPQGPTSALQGSRNKVTPSASEGSGNEAIPS* 0
>PIN_pheMad Phelsuma madagascariensis (gecko) Deut.Saur.Lepi AB022881 full Gt pinopsin no_ref AB022881
0 MHVQMANASQASLKNGTLSPFDGPQWPHRASRRVYTSLAALMGVVVLSASLANGLVIAVSVRFKRLRSPLNYILVNLATADLLVTFFGSIISFVNNAVGFFVFGKTACRFEGFMVSLT 1
2 GIVGLWSLAILAFERYLVICKPVGDFQFQRRHAVIGCLYTWGWSLIWTVPPLFGWSSYVPE 1
2 GLGTSCGPNWYMGGTNNNSYIVALFVTCFALPLSMILFSYANLLLTLRA 0
0 VAAQQKEQETTQRAEKEVTRMVITMVMAFLVCWLPYATFAMVVATTKDLSIQPGLASLPSYFSKTATVYNPIIYVFMNKQ 0
0 FRSCLLNTVSCGRIPQTMPGTPATTAVRGGFVLTSEGRGNKVASTELHS* 0
>PIN_podSic Podarcis sicula (lizard) Deut.Saur.Lepi DQ013042 16688437 full Gt pinopsin
0 MQASNASWVEVRNRTPGPFEGPQWPYLAPQSTYISVAVLMGLVVISATLVNGLVIVVSVQFKKLRSPLNYVLVNLAVADLLVTFFGSTISFVNNAQGFFIFGQATCEFEGFMVSLT 1
2 GIVGLWSLAILAFERYLVICKPVGDFRFPARHAVLGCAFTWGWSFVWTVPPLLGWSSYVPE 1
2 GLRTSCGPNWYSGGSSNNSYIMTLFVTCFAMPLSTILFSYANLLMTLRT 0
0 VAAQQKEQETTQRAEREVTRMVVAMVAAFLVCWLPYASFAMVVATHKDLAIRPALASLPSYFSKTATVYNPIIYVFMNKQ 0
0 FRSCLLYKMSCGHRALSSQDTTPAGISLPGRLTTSASKGSRNQVSPS* 0
>PIN_xenTro Xenopus tropicalis (frog) Deut.Amph.Anur genomic full Gt pinopsin
0 MRAGNMSAYEAPGPYDGPQWPHLAPRSTFLTVAAVMCMVVILAFFVNGLVIVVTLKYKKLRSPLNYILVNLAIANLLVTIFGSSVSFSNNVVGYFFMGKTMCEFEGFMVSLT 1
2 GIVGLWSLAILAFERYLVICKPMGDFRFQQKHAILGCSFTWVWSFIWTSPPLFGWCSYVPE 1
2 GLRTSCGPNWYTGGTNNNSYIMALFLTCFIMPLSTIIFSYSNLLMALRA 0
0 VAAQQKDSETTQRAEKEVTRMVIAMVLAFLICWLPYASFAVVVAVNKDVVIEPTVASLPSYFSKTATVYNPIIYVFMNKQ 0
0 FRNCLMTLLCCGRSFGDDETSSASGRTDVTSVSEAGGNKVTPA* 0
>PIN_bufJap Bufo japonicus (toad) Deut.Amph.Anur AF200433 9537517 full Gt pinopsin classifies oddly
0 MHSANMSALETPGPFEGPQWPHVAPRSTYLTVAVLMGMVVFLAFFVNGMVIVVSLKYKKLRSPLNYILVNLAVADILVTMFGSTVSFHNNIFGFFTLGKLVCELEGFVVSLT 1
2 GIVGLWSLAILAFERYIVICKPMGDFRFQQRHAVMGCAFTWIWAFLWTSPPLIGWCSYVPE 1
2 GLGTSCGPNWYTGGTNNNSYILALFTTCFMMPLTTIIFSYSNLLLALRA 0
0 VAAQQKESETTQRAEREVTRMVIAMVLAFLICWLPYAVFAIVMASNKNVVIDPTLASMPSYFSKTATVYNPVIYVFMNKQ 0
0 FRDCLTKLLCCGRNPFGEDETSTTSGRTDVTSVSEGGGNKVTPA* 0
>PIN_calMil Callorhinchus milii (elephantfish) Deut.Chon.Holo genomic frag Gt pinopsin
0  FGSTVSFSNNINGYFVLGETVCQFEGFMVSLT 1
2 GIVGLWSLAILAFERYIVICKPMGDFRFQQKHAVWGCLFTWLWSLFWTLPPLFGWCSYVPE 1
2 GLRTSCGPNWYTGGANNSSYVVALFITCFTLPLSLIIFSYASLLVVLRA 0
>VAOP_galGal Gallus gallus (chicken) Deut.Saur.Arch genomic 19664923 full Gt vertebrate ancient opsin exon 1 genbank error new stop *RKNGDEH
0 MDVFRALGNESLLSNSSGPARWDPFHHPLDSIQPWHFRLVAAVMFVVTSLSLAENLAVILVTFKFKQLRQPVNYVIVNLSVADFLVSLTGGTISFLANLKGYFYMGHWACVLEGFAVTFF 1
2 GIVALWSLALLAFERYIVICRPVGNMRLRGKHAAQGIAFVWTFSFIWTIPPTMGWSSYTTSKIGTTCEPNW 2
1 YSGAYNDRSYIIAFFTTCFIVPLLVILVSYGKLLQKLRK 0
0 VSNTQGRLRTARKPERQVTRMVVVMIIAFLICWMPYAVFSILATAYPSIELDPHLAAIPAFFSKTATVYNPIIYVFMNKQ 0
0 FRMCLIQMFKCSAIETAESNMNPTSERATLTQDKRDSQLSVMAVRSTIS* 0
>VAOP_taeGut Taeniopygia guttata (finch) Deut.Saur.Arch genomic full G? vertebrate ancient opsin last exon newly truncated
0 MHLEYLKMGHFCPVTLLLPDGDPFHRPLDSIQPWQFKLLAAVMLLVTSLSLAENLAVILVTFKFKQLRQPINYIIVNLSVADFLVSLTGGTISFLTNLKGYFFMGYWACVLEGFAVTFF
2 GIVALWSLALLAFERYIVICRPLRNARLRGKHAALGIVFVWSFSFIWTIPPTTGWSSYTTSKIGTTCEPNW 2
1 YSGAYADHTYIITFFTTCFIVPLLVILVSYGKLVWKLKK 0
0 VSDAQGRLGAARRPERQVTRMVVFMIVAFLICWMPYATFSILVTAYPSIELDPCVAAIPAFFSKTATVYNPVIYVFMNKQ 0
0 FRQCLIQMFSCSAIGTAESNMKLTSERAVLMQGRRGSKRTPMAVHSTVLKRKTGDEHRADDLWLF* 0
>VAOP_anoCar Anolis carolinensis (lizard) Deut.Saur.Lepi genomic full Gt vertebrate ancient opsin syn(+INPP5A -NXK6 +GPR125 +KNDC1)
0 MAGLRREAENDSWLFDPSSSSAPFDPFLQPLDIIEPWNFHLISALMFVVTLFSLSENFTVILVTIKFKQLRQPLNYVIVNLSVADFLVSLIGGTISFSTNLKGYFYMGHWACVLEGFAVTFF 1
2 GIVALWSLALLAFERYVVICRPLGNMRLNGKHAALGVAFVWIFSFIWTVPPTMGWSSYTTSKIGTTCEPNW 2
1 YSGDYNDHTFIITFFTTCFILPLLVILVSYGKLMRKLRK 0
0 VSDTQGRLGTTRKPERQVTGMVVIMILAFLICWSPYAAFSILVTACPSIELDPRLAAIPAFFSKTATVYNPVIYVFMNNQ 0
0 FRKCLVQLFQCSSQETMDANVNPISEKDTLTHTKHCGEMSTVAAHVIVFNPRSEDEQGSCQSFAQLAISENKVYPL* 0
>VAOP_xenTro Xenopus tropicalis (frog) Deut.Amph.Anur genomic full Gt vertebrate ancient opsin syn(- +GSTO2 -C10orf92 -) new
0 MPTNVSLLATPENSTVWNPFTGPLKTIEAWNFHLLAALMFVVTSLSIAENFIVILVTAKFKQLRQPLNYIIVNLSVADFLVSVIGGTISIATNSRGYFYLGSWACVLEGFAVTFF 1
2 GIVALWSLSVLAFERYIVICRPLGNLRLQGKHSALAIIFVWVFSFVWTIPPTMGWSSYTTSKIGTTCEPNW 2
1 YSGEMRDHTYIITFLTTCFVFPLLVIFMSYGKLMRKLRK 0
0 VSDTQGRLGSTRKPEKEVTRMVVIMILAFLICWTPYAAFSILITAHPTIDLDPRLAAIPAFFAKTASMYNPIIYVYMNKQ 0
0 FRRCLYQMFNINDPEAKESNLNPTSERGVLTRNNNGGEMLAIATHITSSAVTNREEEKSSSNSFAHIPVSDNKVCPM* 0
>VAOP_danRer Danio rerio (zebrafish) Deut.Acti.Otoc NM_131586 17067577 full Gt valop assembly missing exon 3
0 MEASSAAVNAVSPAEDPFSAPLSSIAPWNYSVLAALMFVVTALSLSENFTVMLVTFRFQQLRQPLNYIIVNLSLADFLVSLTGGSISFLTNYHGYFFLGKWACVLEGFAVTFF 1
2 GIVALWSLAVLAFERFFVICRPLGNIRLRGKHAALGLVFVWSFSFIWTVPPVLGWSSYTVSRIGTTCEPNW 2
1 YSGNFHDHTFIITLFSTCFIFPLGVIIVCYCKLIRKLRK 0
0 VSNTHGRLGNARKPERQVTRMVVVMIVAFMVAWTPYAAFSIIITAHPSMHVDPRLAAIPAFVAKTAAVYNPIIYVFMNKQ 0
0 FRKCLVQLLSCSKVTVVEGNNNQTTERAGMTSGSNTGEMSAIAARVSVPKTEENPGDRSTFSHIPIPENKVCPM* 0
>VAOP_tetNig Tetraodon nigroviridis (pufferfish) Deut.Acti.Perc genomic full G? vertebrate ancient opsin syn(INPP5A NKX6 +VAOP GABRP KNDC1)
0 MESLSLSVNGVSHTVAAELAPTNDPFSGPINNIAQWNFTILAVLMFVVTALSLSENFLVMFITFKFKQLRQPLNYIIVNLAIADFLVSITGGLISFLTNARGYFFLGRWACVLEGFAVTYF 1
2 GIVAMWSLAVLSFERFFVICRPLGNMRLQAKHAVIGLLFVWTFSFVWTFPPVLGWNRYTVSKIGTTCEPDW 2
1 YSNNMTSHSYIITFFVTCFILPLGVIFFCYGKLLRKLRK 0
0 VSHGRLATARKPERQVTRMVVVMIVAFMVAWTPYATFAILVTIYPTIELDPRLASIPAFFSKTAAVYNPIIYVFMNKQ 0
0 FRKCLMQHFIGGGGTIESNMNPTSERPGITADSHTGEMSAIAARVPVGASASPLSDDSPTAQLPIPENKVCP* 0
>VAOP_takRub Takifugu rubripes (fugu) Deut.Acti.Perc genomic full Gt vertebrate ancient opsin syn(+INPP5A -NXK6 - +KNDC1)
0 MESLSLSVNGVSYTVAAELAPTNDPFTGPINNIAQWNFTILAVLMFVVTSLSLCENFLVMFITFKFKQLRQPLNYIIVNLAIADFLVSLTGGLISFLTNARGYFFLGRWACVLEGFAVTYF 1
2 GIVAMWSLAVLSFERFFVICRPLGNMRLQAKHAAIGLLFVWTFSFVWTFPPVLGWNRYTVSKIGTTCEPDW 2
1 YSNNMTSHSYIITFFSTCFILPLGIIFFCYGKLLRKLRK 0
0 VSHGRLATARKPERQVTRMVVVMIVAFMVAWTPYATFAILVTIHPTIELDPRLASIPAFFSKTAAVYNPIIYVFMNKQ 0
0 FRKCLIQHFIGMGVMAESNMNPTSERPGITAESQTGEMSAIAARVPVGATAALHSDGSPTDCGSLAQLPIPENKVCPI* 0
>VAOP_gasAcu Gasterosteus aculeatus (stickleback) Deut.Acti.Perc genomic full Gt vertebrate ancient opsin
0 MDTLSLSVNAVSHTVAAELPATSDPFNGPIKNIAPWNFTILAVLMFVVTSLSLSENFLVMFVTFKYKQLRQPLNYIIVNLAIADFLVSLTGGVISFLTNARGYFFLGKGACVLEGFAVTFF 1
2 GIVALWSLAVLSFERFFVICRPLGNIRLQPKHAILGLLFVWTFSFIWTFPPVLGWNRYTISKIGTTCEPDW 2
1 YSTNMIDHSYIITFFATCFILPLGVIFFCYGKLLRKLRK 0
0 VSHGRLATAKKPERQVTRMVVVMIVAFMVGWTPYAVFSLLVTSHPSIKLDPRLASIPAFFSKTAAVYNPIIYVFMNKQ 0
0 FRKCLIQLFSGRGTIPDGHLDPTSERPGMSQTGEMSAIATRIPMSSTVSPRSDDSPTDCVSFAQLPIPENKVCPM* 0
>VAOP_oryLat Oryzias latipes (medaka) Deut.Acti.Perc NM_001136515 full Gt vertebrate ancient opsin DK020629 brain DK098095 embryo
0 MDSLSLSVNAVSFTVATEIFSTDDPFTGPIKNIAPWNFTVLAVLMFVITSLSLTENFLVMFVTFKFKQLRQPLNYIIVNLAIADFLVSLTGGLISFLTNARGYFFLGKWACILEGFAVTFF 1
2 GIVALWSLAVLSFERFFVICRPLGNIRLQSKHAMLGLLFVWTFSFIWTFPPVLGWNRYTVSKIGTTCEPDW 2
1 YSTNMSDHSYIITFFATCFILPLGVIFYCYGRLLRKLRKVS 0
0 VSHGRLATARKPERQVTRMVVVMIVAFMVGWTPYAVFSILVTAHPTIKLDPRLASIPAFFSKTAAVYNPIIYVFMNKQ 0
0 FRKCLIQHFTGMGTIPESNLNQTSERPGITAESHTGEMSAIAARIPMGGTTSPRSDDSQTDCGSFAQLPIPENKVCPL* 0
>VAOP_salSal Salmo salar (salmon) Deut.Acti.Salm NM_001123626 9136902 frag Gt vertebrate ancient opsin first VAOP seq, last exon wrong AF001499
0 MDTLRIAVNGVSYNEASEIYKPHADPFTGPITNLAPWNFAVLATLMFVITSLSLFENFTVMLATYKFKQLRQPLNYIIVNLSLADFLVSLTGGTISFLTNARGYFFLGNWACVLEGFAVTYF 1
2 GIVAMWSLAVLSFERYFVICRPLGNVRLRGKHAALGLLFVWTFSFIWTIPPVFGWCSYTVSKIGTTCEPNW 2
1 YSNNIWNHTYIITFFVTCFIMPLGMIIYCYGKLLQKLRK 0
0 VSHDRLGNAKKPERQVSRMVVVMIVAYLVGWTPYAAFSIIVTACPTIYLDPRLAAAPAFFSKTAAVYNPVIYVFMNKQ 0
>VAOP_pleAlt Plecoglossus altivelis (smelt) Deut.Acti.Salm AB074483 11779166 full Gt vertebrate.ancient.opsin brain and amacrine cells of retina
0 MDTLRIPVNGVSYTEATEILKPEDPFTGPLSNIAPWNFTFLAVLMFFVSFLSLCENFTVMFVTFKFKQLRQPLNYIIVNLSIADFLVSLSGGLISFLTNAKGYFFLGKWACVLEGFAVTYF 1
2 GIVAMWSLAVLSFERFFVICRPLGNIRLRGKHAVLGLLFVWTFSFIWTIPPVLGWSSYTVSKIGTTCEPNW 2
1 YSTKLSDHIYIITFFFTCFILPLGVIIFCYGKLLRKLRK 0
0 VSHGRLGNARKPERQVTRMVVVMIVAFMVGWTPYAAFSIVVTACPHIYIDPRMAAIPAFFSKTAACYNPVIYVFMNKQ 0
0 FRKCLIKLFTGKGTIPEGNLGQTSERPGMTAESQTGEMSAIAARIPVGGTAATKSDEQPSECNSFAQLPIPENKVCPI* 0
>VAOP_rutRut Rutilus rutilus (minnow) Deut.Acti.Otoc AY116411 12906786 full Gt vertebrate ancient opsin
0 MELFPVAVNGVSHAEDPFSGPLTFIAPWNYKVLATLMFVVTAASLSENFAVMLVTFRFTQLRKPLNYIIVNLSLADFLVSLTGGTISFLTNYHGYFFLGKWACVLEGFAVTYF 1
2 GIVALWSLAVLAFERFFVICRPLGNIRLRGKHAALGLLFVWTFSFIWTIPPVLGWSSYTVSKIGTTCEPNW 2
1 YSGNFHDHTFIIAFFITCFILPLGVIVVCYCKLIKKLRK 0
0 VSNTHGRLGNARKPERQVTRMVVVMIVAFMVAWTPYAAFSIVVTAHPSIHLDPRLAAAPAFFSKTAAVYNPVIYVFMNKQ 0
0 FRKCLVQLLRCRDVTIIEGNINQTSERQGMTNESHTGEMSTIASRIPKDGSIPEKTQEHPGERRSLAHIPIPENKVCPM* 0
>VAOP_cypCar Cyprinus carpio (carp) Deut.Acti.Otoc AF233520 -------- full Gt vertebrate.ancient.opsin ---
0 MESLAAAVNGVSHTEDPFSGPLSSIAPWNYRVLAALMFVVTSVSLCENFTVMLVTFRFKQLRQPLNYIIVNLSLADFLVSLSGGTISFLTNFHGYFFLGRWACVLEGFAVTF 1
2 FGIVALWSLAVLAFERFFVICRPLGNIRLRGKHAALGLLFVWSFSFVWTIPPVLGWSSYTVSKIGTTCEPNW 2
1 YSGNFQDHTFIITFFTTCFIFPLAVIIVCYCKLLRKLRK 0
0 VSNTHGRLGNARKPERQVTRMVVVMIVAFMVAWTPYAAFSIVVTALPSIHLDPRLAAAPAFFSKTAAVYNPIIYVFMNKQ 0
0 FRKCVVQLLSCRDVTVVEGNINQTTDRAGLTNESNTGEMSAIAARIPAAGTVPPKTEEPPNERSSFTQIPIPENKVCPM* 0
>VAOP_ictPun Ictalurus punctatus (catfish) Deut.Acti.Otoc FJ839436 -------- full Gt vertebrate.ancient.opsin ---
0 MGSFGTAVRGVNYTEAADVIQPEDPFSGPVKSIAPWNFKVLAAWMVVITSLSLSENFLVMLVTYKFKQLRQPLNFLIVNLSLADFFMSLIGGTLSVVTNYRGYFFLGSWACVLEGFAVTF 1
2 FGIVGMWSLATLAFERYFVICRPLGNVRLQVKHAVLGLLFVWTFSFIWTIPPVLGWSSYTVSKIGTTCEPNWYSGDPHDHTFIITFFLTCFILPLAVIIVCYSKLLRKLRK 0
0 VSNSHGRLVNARKPDRQVSHMVVVMIVAFVVAWTPYALFSFIVTVHPTIYLDPIMAAVPAFFAKTAAVYNPIIYVFMNKQ 0
0 FRKCLIQLLSCSGNTTVEVNQSTDRAGMIGESNTGEMSAIAARIPAASTTSPPKANEQHSNSCSYSQLPIPENKVCPM* 0
>VAOP_calMil Callorhinchus milii (elephantfish) Deut.Chon.Holo genomic frag Gt vertebrate ancient opsin
0 VASTQGRLGVARKPEKQVTRMVIVMILAFLFCWTPYAAFSITVTACPTIKLDPRLAAIPAFFSKTATVYNPIIYVFMNKQ 0
>VAOP_petMar Petromyzon marinus (lamprey) Deut.Agna.Hype U90667 9427550 full Gt vertebrate ancient opsin exons 123 in traces pineal gland-specific
0 MDALQESPPSHHSLPSALPSATGGNGTVATMHNPFERPLEGIAPWNFTMLAALMGTITALSLGENFAVIVVTARFRQLRQPLNYVLVNLAAADLLVSAIGGSVSFFTNIKGYFFLGVHACVLEGFAVTYF 1
2 GVVALWSLALLAFERYFVICRPLGNFRLQSKHAVLGLAVVWVFSLACTLPPVLGWSSYRPSMIGTTCEPNW 2
1 YSGELHDHTFILMFFSTCFIFPLAVIFFSYGKLIQKLKK 0
0 ASETQRGLESTRRAEQQVTRMVVVMILAFLVCWMPYATFSIVVTACPTIHLDPLLAAVPAFFSKTATVYNPVIYIFMNKQ 0
0 FRDCFVQVLPCKGLKKVSATQTAGAQDTEHTASVNTQSPGNRHNIALAAGSLRFTGAVAPSPATGVVEPTMSAAGSMGAPPNKSTAPCQQQGQQQQQQGTPIPAITHVQPLLTHSESVSKICPV* 0
>PPIN_anoCar Anolis carolinensis (lizard) Deut.Saur.Lepi genomic full Gt parapinopsin syn(-CPEB2 -CACNA2D3 +SELK) syntenic deleted chicken
0 MDSLDTNTLSPNASTVRVVLMPRIGYTIIAIIMATSCTLSVILNTAVIAITIKYRQLRQPINYSLVNLAIADLGAALLGGSLNVETNAVGYYNLGRVGCVTEGFAMAFF 1
2 GIVALCTIAVIAVDRAIVIAKPMGTITFTTRKAMIGVAVSWIWSLVWNTPPLFGWGGYQMEGVMTSCAPDWANSDPINVSYIICYFLFCFTIPFITILASYGYLIWTLRQ 0
0 VAKVGLAQRGSTTKAEAQVSRMVIVMVMAFLICWLPYATFALVVVGNPQIYINPIIATIPMYMAKSSTFYNPIIYIFMNKQ 0
0 FRDCLVRCLLCGRNPCASEQTDEDDLEVSTIAPAPSSRRGKVAPV* 0
>PPIN_xenTro Xenopus tropicalis (frog) Deut.Amph.Anur genomic full Gt parapinopsin para bistable UV lamprey pineal broken contigs
0 MADEALLPPMMNVTNEEMHPGKVLMPRIGYTILALIMAVFCAAALFLNVTVIVVTFKYRQLRHPINYSLVNLAIADLGVTVLGGALTVETNAVGYFNLGRVGCVIEGFAVAFF 1
2 GIAALCTIAVIALDRVFVVCKPMGTLTFTPKQALAGIAASWIWSLIWNTPPLFGWGSYELEGVMTSCAPNWYSADPVNMSYIVCYFSFCFAIPFLIIVGSYGYLMWTLRQ 0
0 VAKLGVAEGGTTSKAEVQVSRMVIVMILAFLVCWLPYAAFAMTVVANPGMHIDPIIATVPMYLTKTSTVYNPIIYIFMNKQ 0
0 FQECVIPFLFCGRNPWAAEKSSSMETSISVTSGTPTKRGQVAPA* 0
>PPIN_danRer Danio rerio (zebrafish) Deut.Acti.Otoc XM_681591 full Gt parapinopsin syn(- - +SELK -)
0 MESETSTAASGSIAEVMPRMGYTILAVIIGVFSVCGVILNVTVITVTLKYKQLRQPLNFALVNLAVADLGCAVFGGLPTVVTNAMGYFSLGRVGCVLEGFAVAFF 1
2 GIAALCSVAVIALERCMVVCRPVGSISFQTRHAVFGVAVSWLWSFIWNTPPLFGWGRLQLEGVRTSCAPDWYSRDLANVSFIVCYFLLCFALPFSVIVYSYTRLLWTLRQ 0
0 VSRLQVCEGGSAARAEAQVSCMVVVMILAFLLTWLPYASFALCVILIPELYIDPVIATVPMYLTKSSTVFNPIIYIFMNRQ 0
0 FRDRALPFLLCGRNPWAAEAEEEEEETTVSSVSRSTSVSPA* 0
>PPINa_tetNig Tetraodon nigroviridis (pufferfish) Deut.Acti.Perc genomic full G? parapinopsin
0 MKPSVYLNTSLYLGPPEEPPLPRSGFIVLSILMALVTGPAIVLNATVIIVSLMHKQLRQPLNYALVNMAAADLGTAVSGGLLSVVNNAQGHFSLGRTGCVLEGFAVSLC 1
2 GIASLCTVALIAVERMFVICKPLGQMQFQKQHALAGISLSWLWSLTWNLPPLFGWGRYELEGVGTSCAPDWQSREPHNVSYVLAYFTVCFAAPFAIILVSYAKLMWTLHK 0
0 VTKMTCLEGGAVAKSEMKVAYMVVLMVATFLLSWLPYAGLSMLVVFKPDVEINPLVGTVPVYLAKSSTAYNPIIYIYLNKQ 0
0 FRKYALPFLLCRRALEAEDEVSETTVESSRRVSPS* 0
>PPINa_takRub Takifugu rubripes (fugu) Deut.Acti.Perc genomic full G? parapinopsin
0 MKPSAFYLNASLYLGPQGEPPLPRSGFIALSVIMALLTGPAIVLNATVIIVSLMHKQLRQPLNYALVNMAVADLGTAMTGGLLSVVNNAQGYFSLGRTGCVLEGFAVSLC 1
2 GIASLCTVALIAVERMFVICKPLGQMQFQKQHALGGIALAWLWSLTWNLPPLFGWGRYELEGVGTSCAPDWHSREPQNVSYVLAYFTVCFAAPFVIILVSYSKLMWTLHK 0
0 VTKMACMEGGAVAKSEMTVAYMVILMVVIFLISWLPYAGLSMLVVLSPDVKIHPLVGTVPVYLAKSSTVYNPIIYIYLNKQ 0
0 FRKYAVPFLLCGRELEMEDELSMTTVETSNRVSPA* 0
>PPINa_gasAcu Gasterosteus aculeatus (stickleback) Deut.Acti.Perc DN691174 full G? parapinopsin adult eyes
0 MQPSHTFSNSSAYTGPHGEPPLSRTGFIILSIIMAGFTGPAIVLNATVIIVTLMHKQLRQPLNYALVNMALADLGTAMTGGVLSVVNNAQGYFSLGRSGCVMEGFAVSLF 1
2 GITSLCTVALIAVERMFVVCKPLGQIIFQKKHAVGGIAISWLWSLSWNLPPLFGWGRYELEGVGTSCAPDWHNQDPKNVSYIVAYFAVCFAVPFALILASYTKLMWTLHQ 0
0 VSKMTCLEGGAVAKGEMKVASMVVLMVLTFLISWLPYASLAMLVVYNPKVEIHALVGTVPVYLAKSSTVFNPIIYIYLNKQ 0
0 FRKYAVPFLLCCKEPLDDEEASEAATTVEISPSKVSPA* 0
>PPIN_ictPun Ictalurus punctatus (catfish) Deut.Acti.Otoc genomic full Gt parapinopsin index sequence
0 MASIILINFSETDTLHLGSVNDHIMPRIGYTILSIIMALSSTFGIILNMVVIIVTVRYKQLRQPLNYALVNLAVADLGCPVFGGLLTAVTNAMGYFSLGRVGCVLEGFAVAFF 1
2 GIAGLCSVAVIAVDRYMVVCRPLGAVMFQTKHALAGVVFSWVWSFIWNTPPLFGWGSYQLEGVMTSCAPNWYRRDPVNVSYILCYFMLCFALPFATIIFSYMHLLHTLWQ 0
0 VAKLQVADSGSTAKVEVQVARMVVIMVMAFLLTWLPYAAFALTVIIDSNIYINPVIGTIPAYLAKSSTVFNPIIYIFMNRQ 0
0 FRDYALPCLLCGKNPWAAKEGRDSDTNTLTTTVSKNTSVSPL* 0
>PPIN_oncMyk Oncorhynchus mykiss (trout) Deut.Acti.Salm genomic full Gt parapinopsin
0 MDHQQLLPNLHGNISSSPGSVSEALLSRTGFTILAVIIGVFSVSGVCMNVLVIMVTMRHRKLRQPLNYALVNLAVADLGCALFGGLPTMVTNAMGYFSMGRLGCVLEGFAVAFF 1
2 GIAGLCSVAVIAVDRYVVVCRPMGAVMFQTRHAVGGVVLSWVWSFLWNTPPLFGWGSFELEGVRTSCSPNWYSREPGNMSYIILYFLLCFAIPFSIIMVSYARILFTLHQ 0
0 VSKLKVLEGNSTTRVEIQVVRMVVVMVMAFLLSWLPYAAFALSVILDPSLHINPLIATVPMYLAKSSTVYNPIIYVFMNRQ 0
0 FRDCAVPFLLCGLNPWASEPVGSEADTALSSVSKNPRVSPQ*
>PPINb_takRub Takifugu rubripes (fugu) Deut.Acti.Perc genomic full G? parapinopsin syn(+PCTK1 -PPIN +DDX20 -KCND2) absent medaka zfish
0 MEQGIQEGNSSSLSSVSSGTLSRTGYTVLAFIMGVLSAGGIILNVLVIVVTMKHRQLRQPLSYALVNLAICDLGCALFGGIPTTITSAMGYFSLGRVGCVLEGFAVAFF 1
2 GIASLCTIGVISVERYVVVSNPMGAVLFQTR 2
1 HAVAGVVFSWVWSFVWNTPPLFGWGSFDLEGVRTSCAPNWYSRDVGIMSYIVIYLLFCFAVPFTIITVSYSRLLWTLRQ 0
0 VTGLQVAEGGSTNRVEVQVARMVVVMVLAFLLTWLPYAAMALAVVMDSTLYINPIIATIPVYLAKSSTVYNPIIYIFMNRQ 0
0 FRGCAINTVLCGRRAWITDLQTSEGETTVASTSKSQKISPKGSLN* 0
>PPINb_tetNig Tetraodon nigroviridis (pufferfish) Deut.Acti.Perc genomic full G? parapinopsin syn(-PPIN +DDX20)
0 MEQEIQDGNSSSLNSVSPGILSQTGFTVLAFIMGMLSVGGIILNVLVIVVTLKHRQLRQPLNYALVNLAICDLGCALFGGIPTTVTSAMGYFSLGRLGCVLEGFAVAFF 1
2 GIASLCTIGIISVERYIVVSNPMGAVLFQTR 2
1 HAVAGVVFSWVWSFVWNTPPLFGWGSFELEGVGTSCAPNWYSRDMGNMSYIIIYLLFCFAVPFSIIMVSYSRLLWTLHQ 0
0 VTKLHVAEGGSTNRVEVHVARMVVLMVLAFLLTWLPYASMALAVVMDSTLYIDPVTATIPVYLAKSSTVYNPIIYIFMNRQ 0
0 FRGYAINTILCGRRAWVSEQQTSEGETTVVSVSKSQKISPKGSLQ * 0
>PPINb_gasAcu Gasterosteus aculeatus (stickleback) Deut.Acti.Perc DW621258 full G? parapinopsin syn(+DNMT2 -PPIN +DDX20 -TAZ) 21 day old larvae
0 MERDGNASADAQLLSPSGYAALAAVMGAFSVAGILLNALVIVVTARHRQLRQPLSYALVNLAVCDLGCAACGGLPTTVTSAMGYFSLGRAGCVLEAFAVAFF 1
2 GIASLCTIGVISVERYVVVCYPMGAVLFQTR 1
2 HAVAGVVLSWVWSFVWNTPPLFGWGSYELEGVKISCAPNWYSRDPGNVSYVTIYFLLCFAVPFSVIMVSYSRLLWTLRQ 0
0 VTKLQVSETGSTNRVEVQVARMIVVMVLAFLVTWLPYAAMALAVITDSTLHIDPVIATIPVYLAKSSTVYNPIIYIFMNRQ 0
0 FRGYAVPSILCGWNPWAEEQTSEEETVGSVMKSQRVSPKGSLQE* 0
>PPINb_mayZeb Maylandia zebra (cichlid) Deut.Acti.Perc genomic frag G? parapinopsin
0 1
2 GIASLCTVAVISVERYVVVCYPMGAVLFQTR 2
1 HAVAGVVLSWVWSFVWSTPPLFGWGTFELEGVKTSCAPKWHSRDVGDMSYMIIFFFLCFALPFSVVMVSYSRLLWTLRQ 0
0 GMIVVMVLAFLVTWLPYAALALAVMIDSSLYVDPVIATIPVYFAKSSTVYNPIIYIFMNRQ 0
0 FRGYTVAAVLCGWDPWSSEPQTSENETTVPFFIKTPKKIVPKKSLE*0
>PPIN_calMil Callorhinchus milii (elephantfish) Deut.Chon.Holo genomic frag Gt parapinopsin
0 MDPHNRSANLSEGPGLGGGGAVPGWGPSVRAPLSLVMAVISLSSIVLNSLAIAVVLRFQVLQQPLNYALLSLASADLGTAATGGVLSTVCTALGSFVLGRHSCVAEGFF 1
>PPINa_petMar Petromyzon marinus (lamprey) Deut.Agna.Hype genomic full Gt parapinopsin bistable pineal UV/green
0 MENLTSLDLLPNGEVPLMPRYGFTILAVIMAVFTLASLVLNSTVIIVTLRHRQLRHPLNFSLVNLAVADLGVTVFGASLVVETNAVGYFNLGRVGCVIEGFAVAFF 1
2 GIAALCTIAVIAVDRFVVVCKPLGTLMFTRRHALLGITWAWLWSFVWNTPPLFGWGSYKLEGVRTSCAPDWYSRDPANVSYIVSFFSFCFAIPFLVIVVAYGRLLWTLHQ 0
0 VAKLGMGESGSTAKAEAQVSRMVVVMVVAFLVCWLPYALFAMIVVAKPGVYIDPVIATLPMYLTKTSTVYNPIIYIFMNRQ 0
0 FRDCAVPFLLCGRNPWAEPSSESATTASTSATSVTLASVPGQVSPS* 0
>PPINb_petMar Petromyzon marinus (lamprey) Deut.Agna.Hype genomic frag G? parapinopsin odd genomic
2 GMTALITVCVLAVERYVVVCKPLGGVHFGTQHGLCGVAISWTWALAWSAPPLFGWGRYHYEGVGTSCAPDWADSSPSGRSYMTTYFIFCFALPMIIILFCYTKLMIAIHK 0
0 VSKLGLSANDTAERKVGIMVVVMVFAFFLCWLPYAALAIAVVIKPDLK 0
0 VSPVTASIPVYLAKSSGAYNPIIYIFMHRQ 0
>PPIN_letJap Lethenteron japonicum (lamprey) Deut.Agna.Hype AB116380 14981504 full Gt parapinopsin bistable pineal UV/green
0 MENLTSLDLLPNGEVPLMPRYGFTILAVIMAVFTIASLVLNSTVVIVTLRHRQLRHPLNFSLVNLAVADLGVTVFGASLVVETNAVGYFNLGRVGCVIEGFAVAFF 1
2 GIAALCTIAVIAVDRFVVVCKPLGTLMFTRRHALLGIAWAWLWSFVWNTPPLFGWGSYELEGVRTSCAPDWYSRDPANVSYITSYFAFCFAIPFLVIVVAYGRLMWTLHQ 0
0 VAKLGMGESGSTAKAEAQVSRMVVVMVVAFLVCWLPYALFAMIVVTKPDVYIDPVIATLPMYLTKTSTVYNPIIYIFMNRQ 0
0 FRDCAVPFLLCGRNPWAEPSSESATAASTSATSVTLASAPGQVSPS* 0
>PPINa_cioInt Ciona intestinalis (tunicate) Deut.Uroc.Tuni NM_001032555 11591373 full Gt Ci-opsin1 syn(-HOXB1 +HHEX +CUL4A -) odd exons larval ocellus
0 MDHDVTPTVDLTDGVPQCKDLNPYVLKGDGWVPQHISRANRSTYSFLCVYMTFVFLLSCSLNILVIVATLKNK 0
0 VLRQPLNYIIVNLAVVDLLSGFVGGFISIAANGAGYFFWGKTMCQIEGYFVSNF 1
2 GVTGLLSIAVMAFERYFVICKPFGPVRFEEKHSIF 1
2 GIVITWVWSMFWNTPPLIFWDGYDTEGLGTSCAPNWFVKEKRERLFIILYFVFCFVIPLAVIMICYGKLILTLRQ 0
0 IAKESSLSGGTSPEGEVTKMVVVMVTAFVFCWLPYAAFAMYNVVNPEAQ 0
0 IDYALGAAPAFFAKTATIYNPLIYIGLNRQ 0
0 FRDCVVRMIFNGRNPWVDELVGSQVSSTGSQLTAVSSNKVAPA* 0
>PPINb_cioInt Ciona intestinalis (tunicate) Deut.Uroc.Tuni genomic full Gt parapinopsin syn(-TMEM165 +FUT4 - -) jgi gene model wrong both ends
0 MTTAETTTECYEKNPYIRNEMGWVPKHILIAERHIYTILAVYMTFIFLLAVSLNGFVIIATMKNK 0
0 KLRQPLNYIIINLSIADFLSGLVGGFIGMISNSAGYFYFGKTVCILEGYIVSVA 1
2 GVCGLMSISVMAFERYFVVCKPYGPFTLTNTHAAL 1
2 GIGFTWTWSVLWSTPGLIWLDGYVPEGLGTSCAPNWFSKNK 2
1 SERIFIFVYFVFCFFIPLLVIIICYGKIVLFLKQ 0
0 ATRQSSASSNRQADNKVTKMVLVMISAFLICWTPYGVLSLYNAINPDKQ 0
0 LDYGLGAVPVFFAKTANIYNPLIYIGLNKQ 0
0 FRDGVIKMVFRGRNPWAEEMSTQQRQRSTEAGQPIVSNEV* 0
>PPINa_cioSav Ciona savignyi (tunicate) Deut.Uroc.Tuni genomic full G? parapinopsin
0 MPTEASIAVDVSPTMGIPQCKDINPYVLKGDGWVPQHISRADRSVYSFLAVYMTFICLISCSLNILVITATLKNK 0
0 VLRQPLNYIIVNLAVVDLLSGLVGGVISIFANGAGYFFWGKFMCQVEGYTVSNF 1
2 GVTGLLSIAVMAFERYFVICKPFGPVRFEEKHAVI 1
2 GIAVTWIWAMFWNTPPLIFWDGYDTEGLGTSCAPNWFVKGNTERLFIILYFVFCFLIPLAIIVLCYGKLILQLRQ 0
0 IAKESSLSGGTSPEGEVTKMVVVMVTAFVICWLPYAAFAMYNVVNPEAQ 0
0 IDYALGAAPAFFAKTATIYNPLIYIGLNRQ 0
0 FRDCVVRMIFNGRNPWVDEMVGSQVSSSASQMTAVSSNKVAPA* 0
>PPINb_cioSav Ciona savignyi (tunicate) Deut.Uroc.Tuni genomic full G? parietopsin
0 MSSIPQNYSNGNPYATTDSGWVPEHIEIANRSTYSGLCVFMSFVFVLAVPLNLLVIVATYKNK 0
0 DLRRPINYIIVNLAVADLTCSVVGGLLGVLNNGAGYYFLGKSVCIFEGYVMSVT 1
2 GVCGILSITVMAFERYFVVCKPFGQTNLKWSHAIT 1
2 GIVFTWTWSVIWHTPGLFFWNGYEPEGFGTSCAPNWFSQQK 2
1 SERIFIFAYFAFCFLTPLTIIFACYLKLILFIRK 0
0 VSKKSMVNEADRRDFEVTRMVFVMIAAFLICWLPYGCLSMYNAIHPDNL 0
0 LSYGIGSVPAFFAKTATIYNPIIYMGLNKK 0
0 FRDGVIRMLFKGRNPWLDGRNTTSSTSTRAQGSLINREVDI* 0
>PARIE_anoCar Anolis carolinensis (lizard) Deut.Saur.Lepi genomic full Gd+Go parietopsin syn(+EEA1 -FLJ46688 +BTG1 -) gusducin not transducin
0 MENESSLVLEGAEGYIVRPTIFPRAGYGVLAFLMFINALFSLFNNFLVIAVTLKNPQLRNPINIFILNLSFSDLMMSICGTTIVIATNYHGYFYLGRRFCIFQGFAVNYF 1
2 GIVSLWSLTILAYERYNVVCQPLGTLQMSTQRAYQLLGFIWVFCLFWAVVPLFGWSSYGPEGVQTSCSIGWEERSWNNYSYLIVYFLSCFFIPVLIIGFSYGNVIRSLHG 0
0 LNKKVEQLGGKSNPEEEFRAVIMVLVMVVAFLICWLPYTLFALTVVFNPALNISPLAATIPTYLSKTSPVYNPIIYIFLNKE 0
0 FRECAVEFITCGKVVLTSPEEDISTSAISDEGIAPCKINQVTPV* 0
>PARIE_utaSta Uta stansburiana (lizard) Deut.Saur.Lepi DQ100320 16543463 full Gd+Go parietopsin shift in counterion
0 MENDSSLATELAEGAIVKPTIFPKAGYGVLAFLMFLNALFSIFNNSLVIAVTLKNPQLRNPINIFILNLSFSDLMMSLCGTTIVIATNYYGYFYLGRKFCIFQGFAVNYF 1
2 GIVSLWSLTILAYERYNVVCQPLGTLQMSTKRGYQLLGFIWVFCLFWAVVPLFGWSSYGPEGVQTSCSIGWEERSWSNYSYLIVYFLSCFFIPVLIIGFSYGNVIRSLHG 0
0 LNKKVEQLGGKSSPEEEFRAVIMVLVMVVAFLICWLPYTVFALIVVFNPALNISPLAATIPTYLSKTSPVYNPIIYIFLNKQ 0
0 FRDCAVEFITCGQVVLTSPEEDISTSAIPVEGKGPCKINQVTPV* 0
>PARIE_xenTro Xenopus tropicalis (frog) Deut.Amph.Anur DN070761 16543463 full Gd+Go parietopsin syn(-lum -DCN) lung
0 MDGNSTTPGIAVNLTVMPTIFPRSGYSILSFLMFLNAVFSICNNAIVILVTLKHPQLRNPINIFILNLSFSDLMMALCGTTIVVSTNYHGYFYLGKQFCIFQGFAVNYF 1
2 GIVSLWSLTLLAYERYNVVCEPIGALKLSTKRGYQGLVFIWLFCLFWAIAPLFGWSSYGPEGVQTSCSIGWEERSWSNYSYIISYFLTCFIIPVGIIGFSYGSILRSLHQ 0
0 LNRKIEQQGGKTNPREEKRVVIMVLFMVLAFLICWLPYTVFALIVVINPQLYISPLAATLPTYFAKTSPVYNPIIYIFLNKQ 0
0 FRTYAVQCLTCGHINLDSLEEDTESVSAQAENMLTPKTNQVAPA* 0
>PARIE_danRer Danio rerio (zebrafish) Deut.Acti.Otoc genomic 16543463 full Gd+Go parietopsin syn(- +NT5DC2 +FBXL13)
0 MENFAKTELTMMVQPTIFPRVGYSILSYLMFINTTLSVFNNVLVIAVMVKNLHFLNAMTVIIFSLAVSDLLIATCGSAIVTVTNYEGSFFLGDAFCVFQGFAVNYF 1
2 GLVSLCTLTLLAYERYNVVCKPMAGFKLNVGRSCQGLLLVWLYCLFWAVAPLLGWSSYGPEGVQTSCSLGWEERSWRNYSYLILYTLMCFILPTVIITYCYSNVLLTMRK 0
0 INKSIECQGGKNCAEDNEHAVRMVLAMIIAFFICWLPYTAISVLVVVNPEISIPPLIATMPMYFAKTSPVYNPIIYFLTNKR 0
0 FRESSLEVLSCGRYISRETGGPLMGSSMQRGQSRVNPV* 0
>PARIE_tetNig Tetraodon nigroviridis (pufferfish) Deut.Acti.Perc genomic full G? parietopsin genomic frameshift error
0 MDSASTPWSPHPASGQAEAVTAAPTIFPRVGYSILSFLMFINTVLSIFNNGLAITVMLKNPALLQPINIFILSLAVSDLMIGLCGSLVVTITNYQGSFFIGHTACVFQGFAVNYF 1
2 GLVSLCTLTLLAYERYNVVCKPRAGLKLNMRRSLVGLLFVWTFCLFWAVTPLLGWSSYGPEGVQTSCSLAWEERSWNNYSYLILYTLLCFILPVGVIIYCYTKVLTSMNK 0
0 LNKSVELQGGRSCQKENDHAISMVLAMIIAFFVCWLPYTALSVVVVVDPELRIPPLVATMPMYFAKTSPVYNPIIYFLSNKQ 0
0 FRDATLEVLSCGRYIPHASTRVTFNMCAFNRRSRLPSLSRSINTHSKVSPL* 0
>PARIE_takRub Takifugu rubripes (fugu) Deut.Acti.Perc genomic 16543463 full Gd+Go parietopsin syn(-HSP90B1 +NT5DC2 -KCND3 -FLNC)
0 MDSNSTPWSSPPAPLQAEAVTVAPTIFPRVGYSILSFLMFINTVLSVFNNSLAIAVMLKNPSLLQPINIFILSLAVSDLMIGLCGSLVVTITNYHGSFFIGHTACVFQGFAVNYF 1
2 GLVSLCTLTLLAYERYNVVCKPRAGLKLTMRRSIIGLLFVWTFCLFWAVTPLLGWSSYGPEGVQTSCSLAWEERSWNNYSYLILYTLLCFIFPVGVIIYCYCKVLTSMNK 0
0 LNKSVELQGGLSCRRENKHAINMVLAMIIAFFVCWLPYTALSVVVVVDPELHIPPLVATMPMYFAKTSPVYNPIIYFLSNKQ 0
0 FRDATLEVLSCSRYIPHASSRVSINMRSLNRRSVNTHSKVSPL* 0
>PARIE_gasAcu Gasterosteus aculeatus (stickleback) Deut.Acti.Perc genomic full G? parietopsin syn(-HSP90B1 +NT5DC2 -KCND3 -FLNC)
0 MDSNSTLWSSGSPPPSIHGKMLTITPTIFPRVGYSILSFLMFINTVLTVFNNVLVITVLVRNPSLLQPMNVFILSLAVSDLMIGLCGSLVVTITNYHGSFFIGHTACIFQGFAVNYF 1
2 GLVSLCTLTLLSYERYNVVCRPRNALKLSMRRSIHGLLIVWTFCLFWAVAPLFGWSGYGPEGVQTSCSLAWEERSWSNYSYLVLYTLLCFIVPVAVIIYCYAKVLTSMNT 0
0 LNRSVEVQGGRSSQKENDHAVSMVLAMIIAFFSCWLPYTALSVVVVVDPTLYIPPLVATMPMYFAKTSPVYNPIIYFLSNKQ 0
0 FRDAALEMLSCGRYIAHMPNTVSINMRSLNRRSRLSSLSRNVNSHSKVLPL* 0
>PARIE_petMar Petromyzon marinus (lamprey) Deut.Agna.Hype genomic frag Gd+Go parietopsin
0 LNKKIKRVGGHPDPREEMRATVMVLAMVGAFLACWLPYTVLALCVVLAPGTQIPPLVATLPMYFAKTSPIYNPIIYFFLNRQ 0
>ENC_homSap Homo sapiens (human) Deut.Euth.Euar NM_014322 12242008 full Gt OPN3 encephalopsin syn(-EXO1 -WDR64 -KMO +FH) with intron loss
0 MYSGNRSGGHGYWDGGGAAGAEGPAPAGTLSPAPLFSPGTYERLALLLGSIGLLGVGNNLLVLVLYYKFQRLRTPTHLLLVNISLSDLLVSLFGVTFTFVSCLRNGWVWDTVGCVWDGFSGSLF 1
2 GIVSIATLTVLAYERYIRVVHARVINFSWAWRAITYIWLYSLAWAGAPLLGWNRYILDVHGLGCTVDWKSKDANDSSFVLFLFLGCLVVPLGVIAHCYGHILYSIRM 0
0 LRCVEDLQTIQVIKILKYEKKLAKMCFLMIFTFLVCWMPYIVICFLVVNGHGHLVTPTISIVSYLFAKSNTVYNPVIYVFMIRK 0
0 FRRSLLQLLCLRLLRCQRPAKDLPAAGSEMQIRPIVMSQKDGDRPKKKVTFNSSSIIFIITSDESLSVDDSDKTNGSKVDVIQVRPL* 0
>ENC_otoGar Otolemur garnettii (lemur) Deut.Euth.Euar genomic full G? OPN3 encephalopsin
0 MYSGNRSGGQGFWEGGGAAGAEEPTPEGTLSPAPLFSPSAYERLALLLGSIGLLGVANNLLVLVLYYKFPRLRTPTHLFLVNISLSDLLVSLFGVTFTFVSCLRNGWVWDTVGCVWDGFSGSLF 1
2 GIVSIATLTVLAYERYIRVVHARVINFSWAWRAITYIWLYSLAWAGAPLLGWNRYILDVHGLGCTVDWKSKDANDSSFVLFLFLGCLVVPVGVVAHCYGHILYSIRM 0
0 LRCVEDLQTTQVIKILKYEKKVAKMCFFMIFTFLVCWMPLIVICFLVVNGQGHLVTPTVSIVSYLLAKSNTVYNPVIYIFMLRK 0
0 FRRSLLQLLCFRLLRCQRPAKDLPAAESEMQIRPIVMSQKDGDRPKKKVTFNSSSIIFIITSDESLSVDNSDKTNGSKVDVIQVRPL* 0
>ENC_musMus Mus musculus (mouse) Deut.Euth.Euar NM_010098 full G? OPN3 encephalopsin panopsin 2aa del
0 MYSGNRSGDQGYWEDGAGAEGAAPAGTRSPAPLFSPTAYERLALLLGCLALLGVGGNLLVLLLYSKFPRLRTPTHLFLVNLSLGDLLVSLFGVTFTFASCLRNGWVWDAVGCAWDGFSGSLF 1
2 GFVSITTLTVLAYERYIRVVHARVINFSWAWRAITYIWLYSLAWAGAPLLGWNRYILDIHGLGCTVDWRSKDANDSSFVLFLFLGCLVVPVGIIAHCYGHILYSVRM 0
0 LRCVEDLQTIQVIKMLRYEKKVAKMCFLMAFVFLTCWMPYIVTRFLVVNGYGHLVTPTVSIVSYLFAKSSTVYNPVIYIFMNRK 0
0 FRRSLLQLLCFRLLRCQRPAKNLPAAESEMHIRPIVMSQKDGDRPKKKVTFNSSSIIFIITSDESLSVEDSDRSSASKVDVIQVRPL* 0
>ENC_canFam Canis familiaris (dog) Deut.Euth.Laur DN422921 full early gap G? OPN3 encephalopsin XP_854433 grossly wrong
0 MYSGNRSGGQGHWEGGGAAGAEGPGPAGTLSPAPLFSPGTYERLALLLGSVGLLGVGNNLLVLVLYSKFQRLRTPTHLLLVNLSLSDLLVSLFGVTFTFVSCLRNGWVWDSVGCVWDGFSSSLF 1
2 GIVSITTLTVLAYERYIRVVHARVINFSWAWRAITYIWLYSLAWSGAPLLGWNRYILDVHGLGCTVDWKSKDANDSFFVLFLFLGCLVVPMGVIVHCYGHILYSIRM 0
0 LRCVEDLQTIQVIKILRYEKKVAKMCFLMIFIFLIFWMPYIVICFLVVNGYGHLVTPTVSIVSYLFAKSSTVYNPVIYIIMIRK 0
0 FRRSLLQLLCFRPLRCQRPAKDLPANGSEMQIRPIVMSQKDGDRPKKKVTFNSSSIIFIITSDESVSIDDSDKTSVSKVDVIQVRPL* 0
>ENC_pteVam Pteropus vampyrus (macrobat) Deut.Euth.Laur genomic full G? OPN3 encephalopsin
0 MHSGNRSGGLDSWEGGGAAGAEGPGLAGTLSPGSVFNPSTYERLALLLGSIGLLGVANNLLVLVFYYKFQQVRTPFYLFLVNISFSDLLVSFFGVTFTFVSCLRNGWVWDTVGCVWDGFSSSLF 1
2 GTVSMTTLTVLAYERYIRVVQARAIDFSWAWRTITYIWLYSLGWSGAPLLGWNRYILDVHGLGCAVDWKSKDANDSSFVLFLFLGCLVVPVVVIAHCYGHILYSVQM 0
0 LRCVEDLQTIQVIKILRYEKKMAKMCFLMIFTFLISWMPYIVICFLVVNGYGHLVTPTVSIVSYLFAKSSTVYNPVIYIFMIRK 0
0 FRRFVLQLLCFRPLRCRRPATDLPAGGSEMQIRPIVMSQKDGDRPKKKVTFNSSSIIFVITSDESLSVDDSDKINGSKADGIQVRPL* 0
>ENC_loxAfr Loxodonta africana (elephant) Deut.Euth.Afro genomic full G? OPN3 encephalopsin 2 exons in browser 1 2x
0 MYSGNRSGGQDLWEGGGGSGGAGPAGTLSPAPVFRSGTYERLALLVGSIGLLGVGNNLLVLVLYYKFQRLRTPTHLFLVNISLSDLLVSLFGVTFTFVSCLRNGWVWDTVGCVWDGFSSSLF 1
2 GIASITTLTVLAYERYIRVVHARVINFSWAWRAITYIWLYSLAWSGAPLLGWNRYILDTHGLACTVDWKSNNSSDSSFVLFLFLGCLVVPVGVIAHCYGHILYSIRM 0
0 LRCVEDLQTIQVIKILRHEKKLAKMCLFMIFTFLICWMPYIVICFLVVNGYGHLVTPTISIVSYLFAKSSTVYNPVIYTFMIRK 0
0 FRRSLLQLLCFRLLRCQRPAKDLPVVGSEMQIRPIVMSQKDGDRPKKKVTFNSSSIIFIITSDESLSVNNIDKTNGSKADVIQIRPL* 0
>ENC_monDom Monodelphis domestica (opossum) Deut.Meta.Dide genomic full G? OPN3 encephalopsin syn(-EXO1 -WDR64 +ENC -KMO +FH +RGS7)
0 MYSDNSSDDGGGGYWGSGRAGGASGTGVTGEPGPEGSPRQAPLFSPGTYELLALLIATIGLLGLCNNLLVLVLYYKFQRLRTPTHLFLVNISFNDLLVSLFGVTFTFVSCLRSGWVWDSVGCAWDGFSNTLF 1
2 GIVSIMTLTVLAYERYNRIVHAKVINFSWAWRAITYIWLYSLVWTGAPLLGWNRYTLEIHGLGCSVDWKSKDPNDSSFVIFLFFGCLMLPVGVMAYCYGHILYAIRM 0
0 LRCVEELQTIQVIKILRYEKKVAKMCFLMIAIFLFCWMPYAVICLLVANGYGSLVTPTVAIIASLFAKSSTAYNPIIYIFMSRK 0
0 FRRCLLQLLCFRLLKFQQPKKDRPVIRTEKQIRPIVMSQKVGDRPKKKVTFSSSSIIFIITSDETQMIDENDKNSGTKVNVIQVRPL* 0
>ENC_galGal Gallus gallus (chicken) Deut.Saur.Arch genomic full Gt OPN3 encephalopsin syn(-EXO1 -WDR64 +ENC -PIGM +R
0 MHSGNGTGATSRPQLAAAGHEVPGERPLFSAGTYELLALLIATIGTLGVCNNLLVLVLYYKFKRLRTPTNLFLVNISLSDLLVSVCGVSLTFMSCLRSRWVWDAAGCVWDGFSNSLF 1
2 GIVSIMTLTVLAYERYIRVVHAKVIDFSWSWRAITYIWLYSLAWTGAPLLGWNRYTLEIHGLGCSMDWKSKDPNDTSFVLLFFLGCLVAPVVIMAYCYGHILYAVRM 0
0 LRCVEDFQTSQVIKLLKYEKKVAKMCFLMISTFLICWMPYAVVSLLVTYGYSNLVTPTVAIIPSFFAKSSTAYNPVIYIFMSRK 0
0 FRQCLLQLLCFRLMRFQRIMKEPSGAGNVKPIRPIVMSQKVGDRPKKKVTFSSSSIIFIIASDDTQQIDDNSKHNGTKVNVIQVKPL* 0
>ENC_anoCar Anolis carolinensis (lizard) Deut.Saur.Lepi genomic full Gt OPN3 encephalopsin syn(-EXO1 -WDR64 +ENC -PIGM +RGS7)
0 MFSANGTRSGAGSDLEPGPGQQQQQREASEEEERGAGLSPFSAGTYELLALLVAAIGLLGLCNNLLVLVLYAKFKRLRTPTHLFLVNISLSDLLVSLFGVSFTFGSCLRHRWVWDAAGCVWDGFSNSLF 1
2 GIVSIMTLTVLAYERYIRVVHARVIDFSWSWRAITYIWLYSLAWTGAPLLGWNHYTLEIHGLGCSVDWQSKEPSDSSFVLFFFLGCLAAPVGIMAYCYGHILHAIRM 0
0 LRCVEDLQSIQVIKILRYEKKVAKMCFLMVTTFLICWMPYAVVSLLIAYGYGHLITPTVAIIPSFFAKSSTAYNPVIYIFMSRK 0
0 FRRCLVQLFCVQFLRFKRTLKEQPAIESNKPIRPIVMSQKVGDRPKKKVTFSSSSIIFIITSDDTEQIDVSTKCSDTKINVIQVKPL* 0
>ENC_xenTro Xenopus tropicalis (frog) Deut.Amph.Anur genomic pseu G? OPN3 encephalopsin recent pseudogene I for Schiff K C-term residues lost
0 MPVTNGSHNNSISWLHSKDMFTEDTYHFLALIVATVGFLGLVNNLLVLILYCKFKRLQTPTNLLFFNTSLCHFVFSLLAITFTFMSCVRGSWAFSVEMCVFHGFSKNLL 1
2 GIVSFGTLTVVAYERYARVVYGKYVNSSWSKRSITFVWVYSLAWTGFPLIGWNLYTFETHKLDCSFEWTATDPKDTAFVLLFFLACITLPLSIMAYCYGYILYEIQK 0
0 LRSVKNIQNFQEITILDYEIKMAKMCLLMMLTFLIGWMPYTILSLLVTSGYSKFITPTITVMPSLLAIASAAYNPVIHIFTIKK 0
0 FRQCLVQLLFHNFWRLLKNLNGRLAMKKVKPVLGKGRSHNRPEKKVFSSSDFFTRTTSDTGTHGITESTKGKRTNVRLIQVHPLYP* 0
>ENC_danRer Danio rerio (zebrafish) Deut.Acti.Otoc NM_001111164 full G? OPN3 encephalopsin
0 MNSFNETPTEAHLENYNYIFADETYKLLTFTIGSIGVLGFCNNIIVIILYSRYKRLRTPTNLLIVNISVSDLLVSLTGVNFTFVSCVKRRWVFNSATCVWDGFSNSLF 1
2 GIVSIMTLSGLAYERYIRVVHAKVVDFPWAWRAITHIWLYSLAWTGAPLLGWNRYTLEVHQLGCSLDWASKDPNDASFILFFLLGCFFVPVGVMVYCYGNILYTVKM 0
0 LRSIQDLQTVQTIKILRYEKKVAVMFLMMISCFLVCWTPYAVVSMLEAFGKKSVVSPTVAIIPSLFAKSSTAYNPVIYAFMSRK 0
0 FRRCMLQMLCSRLTSLQHTIKDRPLSRIEHPIRPIVMSQSRTDRPKKRVTFSSSSIVFIIASHDTHPLDITSKCNDEPDINVIQVRPL* 0
>ENC_tetNig Tetraodon nigroviridis (pufferfish) Deut.Acti.Perc genomic full G? OPN3 encephalopsin
0 MSSADDSRSARSGEPSLFAVHTYRLLAAAIGAIGVLGFCNNLAVAALYWRFRRLRTPTNLLLLNISLSDLLVSLLGVNFTFAACVQGRWTWNQATCVWDGFSNSLF 1
2 GIVSIMTLAALAYERYIRVVHAQVVDFPWAWRAIGHIWLYSLAWTGAPLLGWNRYTLEIHRLGCSLDWASKDPNDASFILLFLLACFFVPVGIMIYCYGNILYAVHM 0
0 IRSIQDLQTVQIIKILRYEKKVSVMFFLMISCFLLCWTPYAVVSMMVAFGRKSMVSPTVAIIPSFFAKSSTAYNPVIYVFMSRK 0
0 FRRCLLQLLCSRLSWLQRGLKERPLAPVQRPIRPIVVSRPCGKGTRPKKKVTFSSSSIVFIITSDDFRQLDVTSRAGDSADVNAIQVRPL* 0
>ENC_takRub Takifugu rubripes (fugu) Deut.Acti.Perc genomic full G? OPN3 encephalopsin
0 MNPANGSRSERSAEQLLFSGDTYRVLAFTIGTIGAFGFCNNFVVLALYCRFKRLRTPTNLLLVNISLSDLLVSLFGINFTFAACVQGRWTWTQATCVWDGFSNSLF 1
2 GIVSIMTLAALAYERYIRVVHAQVVDFPWAWRAIGHIWLYALAWTGAPLLGWNRYTLEIHRLGCSLDWASKDPNDASFILLFLLACFFVPVGIMIYCYGNILYAVQM 0
0 IRSIQDLQTVQIIKILRYEKKVSVMFFLMISCFLLCWTPYAVVSMMVAFGRRSMVSPTMAIIPSFFAKSSTAYNPLIYVFMSRK 0
0 FRHCLLQLLCSRLSWLQRSLKERPLAPVQRPIRPIVMSRPCGKGNRPKKKVTFSSSSIVFIITSDDFGQLDVTSKSGDSADVNAIQVRPL* 0
>ENC_gasAcu Gasterosteus aculeatus (stickleback) Deut.Acti.Perc genomic full G? OPN3 encephalopsin
0 MNPDNGTREERSTDHSIFAVGTYKLLAFAIGTIGVFGFCNNVVVIVLYCKFKRLRTPTNLLVVNISLSDLLVSVIGINFTFVSCIRGGWTWSRATCIWDGFSNSLF 1
2 GIVSIMTLASLAYERYIRVVHAQVVDFPWAWRAIGHIWLYSLVWTGAPLLGWNRYTLEIHRLGCSLDWASKDPNDASFILLFLLACFFVPVGIMIYCYGNILYAVQM 0
0 LRSIQDLQTVQIIKILRYEKKVAVMFLLMISCFLLCWTPYAVVSMMEAFGRKNMVSPTVAIIPSFFAKSSTAYNPLICVFMSRK 0
0 FRRCLMQLLCSRVTCLQCNLKERPLAPVQRPIRPIVVSAACGGGRVRPKKRVTFSSSSIVFIITRNDIRHTDVTSNTRESSEANVFQVRPL* 0
>ENC_oryLat Oryzias latipes (medaka) Deut.Acti.Perc genomic full G? OPN3 encephalopsin
0 MNPANESRAGRHEERSVFAVGTYKLLTVIIGTIGVFGFCNNLLVILLYCKFKRLRTPTSLLLVNISLSDLLVSVVGINFTLASCVKGRWMWSQATCVWDGFSNSLF 1
2 GIVSIMTLAALAYERYIRVVHAQVVDFPWAWRAIGHIWLYSLAWTGAPLLGWNRYTLEIHQLGCSLDWASKDPNDAAFILLFLLGCFFVPVGIMIYCYGNILYAVRM 0
0 LRSIEDLQTVQIIKILRYEKKVAAMFLLMISCFLVCWTPYAVVSMMEAFGKKSMVSPTVAIVPSFFAKSSTAYNPLIYVFMNRK 0
0 FRRCFLQLLGSRLCSKISWLQCTLKEHPLTPVERPIRPIVASTSCGSRHRPKKRVTFNSSSIVFMITGDEFQQLDVTSKSRNSSEANVFHVRPL* 0
>ENC_calMil Callorhinchus milii (elephantfish) Deut.Chon.Holo genomic frag G? OPN3 encephalopsin
0 MNPTNSTEPQEEHLFSPNTYKLLAVIIGTIGIVGFCNNILVLLLYYKFKRLRTPTNLLLVNISVSDLLVSVFGLSFTFVSCTQGRWGWDSAACVWDGfSHSLF 1
2 GTVSIVTLTVLAYERYIRVVNAKATNFPWAWRAITYTWFYSLAWSGAPLV
0 yRRCLSQLFCSHLMSLQWSIKDPSSKARNDMPVKPIVLSQKGDRPKKRVTFSSSSIVFIITSDDTQELGSIAGSNATQISIVQVQPL* 0
>ENC_squAca Squalus acanthias (dogfish) EB687868 frag Gt OPN3 encephalopsin
0 MNAANSTDTREESLFSPGTYQVLAVIIGTIGVVGFCNNLLMLVLYCKFKRLRTPTNLFLVNISISDLLLSVFGVIFTFVSCVKGRWVWDSAACVWDGFSNCLF 1
2 GISSIMSLTVLAYERYIRVVNATAIDFSWAWRAITYIWLYSLAWTGAPLIGWNSYTLELHRLGCSVNWDSRNPSDTSFVLFLFLGCLLCPIGVIAYCYG
>ENC_leuEri Leucoraja erinacea (skate) Deut.Chon.Elas FL592692 frag
0 MNTANSTEIPAETLFGAGAYKVLAVVVGTVGAVGFCNNLLMLVLYCKFKRLRSPANLFLVNISISDLLLSVFGIFFTLVSCVKGGWVWDNSACIWDGFSNTLF 1
2 GISSIMSLTVLAYERYLRMVNATAINFTWAWRAVTYIWLYSLAW
>ENC_torCal Torpedo californica (ray) Deut.Chon.Elas EW690209 17309107 frag electric organ
2  WSGAPLLgwNRYTLEMHRLGCSVTwELEKPSDTSFILFLFLGSLLLIPVGVIAYCYGNIFYTIRM 0
0 LQSIEDFQTARFAKTLTNEMNSSKMCFFMISVAFSCWLPYAVTSFMVVYGCTDVITPTITIIFSLLAKSSAISYPIIYIFMSRK 0
0 FRWCLMQLLCFRLVRIKWAIKDRTVRIRSDKPIKPIVIFEKVVNRPKKRVTFSSFSIIFIANDETQDIGSTAELNATNQNVVQVRPLRSERAER* 0
>ENC_petMar Petromyzon marinus (lamprey) Deut.Agna.Hype genomic full Gt OPN3 encephalopsin rough sequence in two contigs
0 MQSPKQDSLHYAGDTGAKAAPDSAQGNASALGSNFLLHGGDLGEGSTAFSAATFRLLAGVVGTIGVAGFLNNLLLVALFVGFKRLQTPTNLLLVNISLSDLLVSVFGNTLTLVSCVRRRWVWGNGGCVWDGFSNSLF 1
2 GIVSISTLTALSYERYARLIKAQVLDFSWAWRAVTYTWLYSAAWTGAPLLGWSRYVLEKHGLGCSIDWASSNPPDAAFVLFFFLGCLAAPLLVMGFCFGRIALAITQ 0
0 FRKLDRLQTPRVLKARCSERKVSAVCLLMMLLFLLCWSPYAVASLFVASGFEHLVSPPVSIVPSLLAKSNAVCNPLLFLLMSGN 0
0 FFRCLRTMFFTLRWRVNLSRVGIVCPQSQRRPRQREAARPKKKATFNSSSIVFIISSSEEDPVEPADAEGEKSDALAAPADTCVVHVKPT* 0
>ENC4_braFlo Branchiostoma floridae (amphioxus) Deut.Ceph.Bran AB050608 12435605 full Gt Amphiop4 syn(-ZFYVE1 +RTF1 -CES1 -POMT2) new exon 12 and 34
0 MALYNNTSSPSQDLLWDAPYSQGHIWDNSSASNSSEDVMDQGKVELQDFSDAGYTAIATCLALI 1
2 GFVGFTNNFVVILLIGCHRQLRTPFNLLLLNMSVADLLVSVCGNTLSFASAVRHRWLWGRPGCVWYGFANSLF 1
2 GIVSLVTLSALAFERYCVVVRSSDMLTYKSSLVVITFIWLYSLLWTSLPLLGWSSYQFEGHN 0
0 VGCSVNWVQHNPDNVSYIVTLMVTCFFVPMVVVCWSYAWIWRTVRM 0
0 SSEAKPECGNSQNAGRLVTTMVVVMIICFLVCWTPYAVMALIVTFGADHLVTPTASVIPSLVAKSSTAYNPIIYVLMNNQ 0
0 FREFLLARLQRVCCRQQAVPRVTPMDDNVHVRLGGEGPSQSQQFLPAGENVENVDMLEYVQENCKPKADSLSTISE* 0
>ENC4_braBel Branchiostoma belcheri (amphioxus) Deut.Ceph.Bran AB050608 12435605 full G? Amphiop4 introns from braFlo
0 MPLYNTSSGPTQGLPWDTPYSQDPIWNDSSPSNSSEDAVVDQGRGELQDFSDAGYTAIATGLALI 1
2 GLVGSMNNFVVILLIGCHRQLRTPFNLLLLNVSVADLLVSVCGNTLSFASAVQHRWLWGRPGCVWYGFANSLF 1
2 GIVSLVTLSALAFERYCVVVRSSEMLTYKSSLGMIAFIWMYSLLWTSLPLLGWSSYQFEGHS 0
0 VGCSVNWVKHNVNNVSYIITLMVTCFFVPMVVVCWSYACIWRTVRM 0
0 SAEMKSEFGNPQNTGRLVTTMVVVMIVCFLVCWTPYTVMALIVTFGADHLVTPTASVIPSLVAKSSTAYNPIIYVLMNNQ 0
0 FREFLLARLRTFCCRQPRMLRVTPMDDNAHARLVGEGPSHAQQVIPSEENGENVEMRKVQGNQLKADSLSTISE* 0
>ENC_strPur Strongylocentrotus purpuratus (sea_urchin) Deut.Echi.Eleu AAGJ02133080 full G? OPN3 encephalopsin terminal exon extended to stop codon
0 MENFTSIVTDGTNEENTDGDAWPGYAHLLAGSFLTLVFIISIIGNSVVLFLFAWDRHLRTPTNMFLLSLTISDWLVTVVGIPFVTASIYAHRWLFAHVGCIS 2
1 YAFIMTFLGLNSLMSHAVIAVDRYLVITKPHF 1
2 GIVVTYPKAFLMISIPWVFSFAWAVFPLAGWGEFTYEGTGAWCSVRWDSDQPQIMSYVLAMMFLTFISSIVIMMYCYICIFLTTRRMPRWATSNSIKTHERNRRRR 2
1 EQKLLKTLIAIAIAFLVAWSPYAITSMIVVFGGSELLSLTATTLPSLFAKSSVMINPIIYAVTSRVFRKSLKK 0
0 MLTSFFPGCMTYIMTDKSPPSSSRPIQLGLCKYHFLY* 0
>TMT5_braFlo Branchiostoma floridae (amphioxus) Deut.Ceph.Bran XM_002589165 12435605 full G? Amphiop5 extra 0 intron
0 MLGMHNVMNATDYDNNNATFAAWNFQRNGTTEEEVEFSGFDTVAVVIAAIGIAGFLSNGAVVLLFLKFRQLRTPFNMLLLNMSVADLLVSVCGNTLSFASAVRHRWLWGRPGCVWYGFANHLF 1
2 GLVSLISLAVISYERYRMVVKPKGPGSSYLTYNKVGLAIIFIYLYCLLWTTLPIVGWSSYQLE 0
0 GPKISCSVAWEEHSLSNTSYIVAIFIMCLLLPLLIIIYSYCRLWYKVKK 0
0 GSQNLPPAIRKSSQKEQKIARMVVVMITCFLVCWLPYGAMALVVSFGGESLISPTAAVVPSLLAKSSTCYNPLVYFAMNNQ 0
0 FRRYFQDLLCCGRRLFDASASVNTCNTSAMPRHSPVFQKPDSDQYNGIQKSREPQMRTTGQNAPYRQWIEMQTIAVVVKADEVNNKFGEVKT* 0
>TMT5_braBel Branchiostoma belcheri (amphioxus) Deut.Ceph.Bran AB050609 12435605 full G? Amphiop5 introns from braFlo
0 MLGIYNVVNATEYGNNTTFAAWDFKRNGTGGEEEVEFFGYDAVAGVIAIIGVVGFVSNGAVVVLFLKFPQLRTPFNLLLLNMAVADLLVSVCGNTLSFASAVRHRWLWGRPGCVWYGFANHLF 1
2 GLVSLISLAVISFLRYRMVVKPKGPGSSYLTYTKVGLAILFIYLYCLLWTTLPIAGWSSYQLE 0
0 GPKIGCSVAWEEHSWSNTSYIVVLFITCLFAPLLIIVYSYYRLWHKVKQ 0
0 GSRNLPAAMRKSSQKEQKIAMMVIVMITCFMVCWLPYGAMALVVTFGGERLISHTAAVVPSLLAKSSTCYNPVVYFAMNSQ 0
0 FRRYFQDLLCCGRRLFDVSQSVVTGNTAMPRNNSQGFRKDDSDQKQDNGLPKQSEGPMCDHSSNESQMEGSRHNTAASQQWIEMQTIAVVVKAVEVDTSAANEP* 0
>TMT_monDom Monodelphis domestica (opossum) Deut.Meta.Dide XM_001372110 full G? syn(+NCK2 -UXS1 +TMT -ST6 GAL2_overlap) -RALY shortened final exon
0 MSNNLTTNLSLEALLSASEDKQRNGLSRTGHTIVAVFLGIILIFGSISNFIVLVLFCKFKVLRNPVNMLLLNISISDMLVCLSGTTLSFASSIQGRWIGGKHGCRWYGFANSCF 1
2 GIVSLISLAILSYERYRTLTLCPGQGADYQKALLAVAGSWLYSLVWTVPPLIGWSSYGTEGAGTSCSVHWTSKSVESVSYIMCLFIFCLVIPILVMVYFYGRLLYAVKQ 0
0 VGKIRKTAARKREYHVLFMVVTAVICYLICWVPYGMIALLATFGPPGVVSPVANVVPSILAKSSTVCNPIIYVLMNKQ 0
0 FYKCFLILFHCQPAQSGPDVSLCPSNVTVIQLGQRKNKDAPGSI* 0
>TMT_macEug Macropus eugenii (wallaby) Deut.Meta.Dipr genomic full G? teleost multiple tissue
0 MSINLTANLSFGTLLPDSEEKQRSGLSRTGHTVTAVFLGLILILGVINNFIVLVLFCKFKVLRNPVNMLLLNISISDMLVCLTGTTLSFASSIRGRWIAGYHGCRWYGFANSCF 1
2 GIVSLISLAVLSYERYRTLTLCPRQGTDYHKALLAVAGSWLYSLIWTVPPLIGWSSYGTEGAGTSCSVHWTSKSVESVSYIMCLFIFCLVIPILFMVYFYGRLLYTVKQ 0
0 VGKIRKSAARKREYHVLFMVVTAVICYLICWVPYGMIALLATFGPPGVVSPVANVVPSILAKSSTVCNPIIYILMNKQ 0
0 FYKCFLILFHCQPASSASDASLCPSKMTVIQLGQRKDKEVPCAIQDLPEVSKKQLCLLSPESNVAPSSGHPQEKMEEKPLSE* 0
>TMT_ornAna Ornithorhynchus anatinus (platypus) Deut.Prot.Mono genomic frag G? teleost multiple tissue
0 GLSRTGHTMVAVFLGIILVFGFMNNLIVLILFCKFKALRNPVNMIMLNISASDMLVCVSGTTLSFASNISGRWIGGDPGCRWYGFVNSCL 1
2 GIVSLISLAVLSYERYRTLTLHPKQSTDYQKAVLAVGASWIYSLIWTIPPLLGWSSYGTEGAGTSCSVHWSSKSPVSVSYIVCLFIFCLVIPVLVMIYCYGRLLYAVKQ 0
0 IGKARKTAARKREYHVLFMVITTVICYLVCWMPYGVTALLATFGQPGTVSPEASVIPSILAKSSTVCNPIIYILMNKQ 0
0 FYKCFLILFHCQPPRAADAPSTYPSQVMVIQLNQRRSRETAGAPQVLLEMKHQTLHLLGPQLHETPSWERSTPVHPE* 0
>TMT_galGal Gallus gallus (chicken) Deut.Saur.Arch XM_001234388 full G? syn(+NCK2 -UXS1 +TMT -ST6 GAL2_overlap +SLC5A7 +SULT1C4)
0 MNHTWTYNLSFGAPTDPVEPRAGLSRNGHTVVAVFLGFILFFGFLNNLIVLILFCKFKTLRNPVNMLLLNISISDMLVCISGTTLSFASNIHGKWIGGEHGCRWYGFVNSCF 1
2 GIVSLISLAVLSYERYSTLTLCNKRSDDYRKALLAVGGSWVYSLLWTVPPLLGWSSYGIEGAGTSCSVRWSSETAESTSYIICLFIFCLVIPVMVMMYCYGRLLYAVKQ 0
0 VGKIHKNTARKREYHVLFMVITTVICYLVCWIPYGVIALLATFGKPGVVTPVASIIPSILAKSSTVCNPIIYILMNKQ 0
0 FYKCFRQLFHCQPPSSTDGEPTCHSKVTVIQLNQKTDGGKLCNNKPRPETDNKVTSLLHPEPGLEPAAKTVPPM* 0
>TMT_taeGut Taeniopygia guttata (finch) Deut.Saur.Arch XM_002192719 full G? teleost multiple tissue
0 MNHTWMYNLSFGAPAHPVEPRAGLSRSGHTVVAVFLGLILFFGFLNNLIVLILFCKFKTLRNPVNMLLLNISVSDMLVCISGTTLSFASNIRGKWIGGDHACRWYGFVNSCF 1
2 GVVSLISLAVLSYERYNTLTLCHKRSDDFRKALLAVAGSWIYSLVWTVPPLLGWSSYGVEGAGTSCSVRWSSESAESTSYIICLFVFCLVVPVMVMMYCYGRLLYAVKQ 0
0 VGKIHKNAARKREYHVLFMVIPTVICYLVCWIPYGVIALLATFGKPGAVTPITSIIPSILAKSSTVCNPIIYILMNKQ 0
0 FYKCFRQLFHCQPPSSTDGEPTCHSKVTVIQLDQRADGGNMCNNEPHPETDSKMTSLLCPETTSKATPPTS* 0
>TMT_anoCar Anolis carolinensis (lizard) Deut.Saur.Lepi genomic full G? teleost multiple tissue syn(+TMT -ST6 GAL2_overlap +SLC5A7)
0 MSELSSNLTFNMSTSIEEPGSGLSRMGHNIVAVFLGLILVFGFLNNLVVLILFCKFKTLRNPVNMLLLNISASDMLVCISGTTLSFVSNIYGRWIGGEHGCRWYGFVNSCF 1
2 GIVSLISLAILSYERYSTLTQTNKRGSDYQKALLGVGGSWLYSLIWTVPPLIGWSSYGLEGAGTSCSVRWTSETLESVTYIICLFIFCLAIPVLVMIYCYARLFYAVKQ 0
0 VGKLRKTSARKREFHVLFMIITTIICYLICWMPYGVIALLATFGRPGLVSPVASVIPSILAKSSTVFNPIIYILMNKQ 0
0 FYKCFLMLLHCQPSSVADGETICQSKVMAIHQNQKAQGGVILKSQVVPQMDEKAICLLSPESSLDPVLESTPQLSKENSFL* 0
>TMT_xenTro Xenopus tropicalis (frog) Deut.Amph.Anur AL773998 full G? syn(-UXS1 +TMT -ST6 GAL2_overlap +SLC5A7) short gastrula frag
0 MSTIKNWTTNISVENSMSYIENDLSLPTEAVLSRTGHTVVAIFLGFILIFGFLNNFVVLILFCKFKTLRTPVNMMLLNISASDMLVCVSGTTLSFTSSIKGKWIGGEYGCQWYGFVNSCF 1
2 GIVSLISLAILSYERYSTLTLYNKGGPNFKKALLAVASSWLYSLVWTVPPLLGWSSYGREGAGTSCSVRWTSESVESVSYIICLFIFCLALPVFVMLYCYGRLLYAVKQ 0
0 VGKIRKIAARKREYHVLFMVITTVICYLLCWLPYGVVALLATFGRPGVISPVASVVPSILAKSSTVFNPIIYILMNKQ 0
0 FYKCFLILFHCHPTSSADGKSICQSNYTVIQLNQKLNNIVAIPGQTQIPESVDKMPCIHRQNNESPSDQMPQSTTEHLISGT* 0
>TMTa_danRer Danio rerio (zebrafish) Deut.Acti.Otoc XM_002192719 full G? syn(-UXS1 +TMT -ST6 GAL2_overlap +GPR89A -pdzk1l)
0 MFFEQADLNYSFNMSEEDRLTLLDEDWSDSPMETLSRAGFIALSVFLGFIMTFGFFNNLVVLVLFCKFKTLRTPVNMLLLNISISDMLVCMFGTTLSFASSVRGRWLLGRHGCMWYGFINSCF 1
2 GIVSLISLVVLSYDRYSTLTVYHKRAPDYRKPLLAVGGSWLYSLIWTVPPLLGWSSYGLEGAGTSCSVSWTQRTAESHAYIICLFVFCLGLPVLVMVYCYGRLLYAVKQ 0
0 VGKIRKTAARKREYHVLFMVITTVVCYLLCWMPYGVVAMMATFGRPGIISPVASVVPSLLAKSSTVINPLIYILMNKQ 0
0 FYRCFRILFCCQRSLLQNGHSSMPSKTTVIQLNRRVNSNAVACTAQISTGTHNHDCSTHVTERSNPPEVIP* 0
>TMTb_danRer Danio rerio (zebrafish) Deut.Acti.Otoc CN506730 full G? teleost multiple tissue syn(-FHL2 +NCK2 +TMT -ST6GAL2_lap) seg dup
0 MFPEETNMSYISNGTDDDLLSALEDWSDTPAEKLSRTGHNVVAVILGSILIFGTLNNLVVLVLFCKFKTLRTPVNMLLLNISVSDMLVCLFGTTLSFAASIRGRWLVGRHGCMWYGFVNSCF 1
2 GIVSLISLAILSYDRYSTLTVYNKRAPDYSKPLLAVGGSWLYSLFWTVPPLLGWSSYGLEGAGTSCSVTWTANTPQSHSYIICLFIFCLGIPVLVMVYCYSRLICAVKQ 0
0 VGRIRKTAARRREYHILFMVITTVVCYLLCWMPYGVVAMMATFGRPGIISPIASVVPSLLAKSSTVINPLIYILMNKQ 0
0 FYRCFLILIHCKHSSLENGQSSMPSRTTGIQLNRRPYSNPVADNAPPSIDLQNDCSTPVSG* 0
>TMT_tetNig Tetraodon nigroviridis (pufferfish) Deut.Acti.Perc genomic full G? syn(-UXS1 +TMT -ST6 GAL2) multiply frameshifted assembly
0 MFSGQAGLNSSFNLSDGRGLEDAPAGRGRLSPTGFVVLSVVLGFIITFGFLNNFIVLLLFCKFKKLRTPVNVLLLNISVSDMLVCLFGTTLSFASSLRGRWLLGRSGCNWYGFINSCF 1
2 GIVSLISLVILSHDRYSTLTVYNKQGINYRKPLLAVGGTWLYSLLWTVPPLLGWSSYGIEGAGTSCSVSWTVQTAQSHAYIICLFIFCLGLPVLVMVYCYSRLLWAVKQ 0
0 VGKIRKTSARKREYHILFMVVTTAACYLVCWMPYGVVAMMATFGPPNIISPVASVVPSLLAKSSTVINPLIYILMNKQ 0
0 FYKCFLILFHCSHWSADNGTTSVPSKITVIQLNRRAYSNTVACADPLSTDALKQCCSAKNASTIEVKLS* 0
>TMT_takRub Takifugu rubripes (fugu) Deut.Acti.Perc genomic full G? teleost multiple tissue
0 MFSGQAGLNYSFNLSDDRELLDAPAGRAKLSPTGFVVLSVVLGFIMTFGFLNNFVVLLLFCKFKKLRTPVNMLLLNISVSDMLVCLFGTTLSFASSIRGRWLLGRIGCSWYGFINSCF 1
2 GIVSLISLVILSYDRYSTLTVYNKQGINYRKPLLAVGGTWLYSLFWTVPPLLGWSSYGIEGAGTSCSVSWTVQTAQSHAYIICLFTFCLGIPILVMIYCYSRLLWAVKQ 0
0 VGRIRKTAARKREYHILFMVVTTAACYLVCWMPYGVVAMMATFGPPNIISPVASVVPSLLAKSSTVINPLIYILMNKQ 0
0 FYKCFLILFHCGHWSADNGNTSMPSKTTAIQLNRRVYSNTVACADQLSTDALKQCCSANTISTKNTSTVEGKLS* 0
>TMT_gasAcu Gasterosteus aculeatus (stickleback) Deut.Acti.Perc genomic full G? teleost multiple tissue
0 MVFGQAGLNHSFNLSDDRELLDTSAGRAKLSPTGFVVLSVMLGFIMTFGFVNNLVVLLLFCKFKKLRTPVNMLLLNISVSDMLVCLFGTTLSFASSLRGKWLLGRSGCSWYGFINSCF 1
2 GIVSLISLVILSYDRYSTLTVYNKAGPDYRKPLLAIGGSWLYSLFWTVPPLLGWSSYGIEGAGTSCSVSWTVQTAQSHAYIICLFTFCLGLPMLVMIYCYSRLLLAVKQ 0
0 VGRIRKTAARRREYHILFMVLTTAACYMLCWMPYGVVAMMATFGPPNIISPVASVVPSLLAKSSTVINPLIYILMNKQ 0
0 FYRCFLILFHCKHWSAENHNTSMPSKTTVIHLNRRVCSNTLPCTAQASTDAANHFCSTSATKHTSPPLQGHGLSLNVLNMIRQENHSHDEAAKNQLDCLT* 0
>TMT_oryLat Oryzias latipes (medaka) Deut.Acti.Perc DK170580 full G? teleost multiple tissue whole embryo
0 MFSGQTGLNFSFNQSDDRELEDTPAGSAKLSQAGFVVLSVVLGFIMTFGFLNNFVVLILFCKFKKLRTPVNMLLLNISVSDMLVCLFGTTLSFASSIRGRWLLGRGGCSWYGFINSCF 1
2 GIVSLISLVILSYDRYSTLTVYNKGGLNYRKPLLAVGGSWLYSLFWTVPPLLGWSSYGLEGAGTSCSVSWTANTAQSHAYIICLFIFCLGLPILVMIYCYSRLLLAVKQ 0
0 VGKIRKTAARKREYHILFMVLTTAACYLLCWMPYGVVAMMATFGPPNIISPVASVVPSLLAKSSTVINPLIYILMNKQ 0
0 FYRCFLILFHCDHWSSENGNTSVPSKTTVIPLNRRIYTNTVAQISTDNAN* 0
>TMT_ictPun Ictalurus punctatus (catfish) Deut.Acti.Otoc FD287269 frag G? teleost multiple tissue 2 transcripts from whole fry
0 WLLGRTGCMWYGFINSCF 1
2 GIVSLISLMILSYERYSTMTVYNNQGPNYRKHLLAVGGSWLYSLIWTVPPLLGWSSYGLEGAGTSCSVSWTDHSPKSHAYIICLFIFCLGLPVLLMVYSYGRLLYAVKQ 0
0 LGKIHKTARRRDYHLLFMITTTVVCYLLCWTPYSVVALMASFGRPGIITPVASIIPSLLAKSSTVINPVIYIFMNKQ 0
0 FYRCFRTLLGYKERSAVPDDHSLMATKNTAIQLKCIMHNNPVPSPAHTPPPFF
>TMTc_xenTro Xenopus tropicalis (frog) Deut.Amph.Anur genomic full G? ciliary uropsin syn(+GPR112 +BRS3 +VGLL1 +TMTx +CD40LG -ARGHGEF7)
0 MLLALNLQNESFLLNLSHGETRDSLPPATGLSRTAHSVVAVCLGCILVLGSLYNSFVLLIFVKFTAIRTPINMILLNISVSDLLVCIFGTPFSFVSSVSGGWLLGQQGCKWYGFCNSLF 1
2 GLVSMISLSMLSYERYLTVLKCTKADMTDYKKSWLCIIVSWLYSLCWTLPPLIGWSSYGLESSGTTCSVVWHSKSSNNISYIVCLFLFCLVLPLFIMIFCYGHIVRVIRG 0
0 VCRINMTTAQKREHRLLFMVVCMVTCYLLCWMPYGLVSLMTAFGKPGMITPTVSIIPSILAKSSTFINPLIYIFMNKQ 0
0 FYRCFIALIKCESGPHHNENISTSRQSREMRLETRCKVQSSIFYTHKARRTKDTTSSPEMQRKLTLTVHYRDDR* 0
>TMTc_danRer Danio rerio (zebrafish) Deut.Acti.Otoc genomic full G? ciliary uropsin syn(+FHL1 +GPR64/112 +TMTx -ARGHGEF7 -RBMX)
0 MVVYIWSLNISSKDTSALNQSGNVSSGDPLEPHDSPPGLSRTGHTVTAVCLGAILLLGCLNNLFVLLVFARFRTLWTPINLILLNISVSDILVCLFGTPFSFASSLYGKWLLGHHGCKWYGFANSLF
2 GIVSLMSLSILSYERYAALLRATKADVSDFRRAWLCVAGSWLYSLLWTLPPFLGWSNYGPEGPGTTCSVQWHLRSTSSISYVMCLFIFCLLLPLVLMIFCYGKILLLIKG 0
0 VTKINLLTAQRRENHILLMVVTMVSCYLLCWMPYGVVALLATFGRTGLITPVTSIVPSVLAKSSTVVNPVIYVLFNNQ 0
0 FYRCFVAFLKCQGEPSVHGQNPQHSSKEDPHVFRPCDGASIHRSAEGPQKKEQHSLSLVVHYTP* 0
>TMTc_tetNig Tetraodon nigroviridis (pufferfish) Deut.Acti.Perc genomic full G? ciliary uropsin syn(-TAF7L +SLC9A7 +FHL1 +TMTx -ARGHGEF7 -RBMX)
0 MVVQPRDCNFSTPDSSVSIFGPSIDARGPWDPQCPGGLSRSSHTAVAVLLGVILVAGILSNSLVLLLFVKYRSLWTPINLILLNINLSDILVCVFGTPFSFAASLQGRWLIGEGGCMWYGFANSLF 1
2 GIVSLVSLSVLSYERCTVVLQPSQVDVSDFRKARFCVGGSWLYALLWTSPPLLGWSSYGPEGAGTTCSVQWQLRSPASVSYVLCLLVFCLLLPFLVMVYSYGRILVAIRR 0
0 VGRINQLTAQRREQHILLMVLSMVSCYMLCWMPYGIMALVATFGKLGLVTPMVSVVPSILAKFSTVVNPIIYMFFNNQ 0
0 FYRCFMAFIRCQKEPEPIQEE* 0
>TMTc_takRub Takifugu rubripes (fugu) Deut.Acti.Perc genomic full G? ciliary uropsin syn(-TAF7L +SLC9A7 +FHL1 +TMTx -ARGHGEF7 -RBMX)
0 MVLQTRECNFSTPDTSVRGPWAPQGPGGMSRTGHTVVAVMLGTILLAGVFGNSVVFLVFVKYRSLRTPINLILLNISLSDILVCVFGTPLSFAASLKGRWLLGERGCEWYGFANSLF 1
2 GIVSLVSLSVLSYERYTVVLQPTQVDVSYFRKAWFCVGGSWLYALFWTLPPLLGWSRYGPEGPGTMCSVQWHLRSPANISYVLCLFIFCLLLPLVVMVYSYGRIWVAVRR 0
0 AGRINLLTAQRREQHILWMVLSMVSCYMLCWMPYGIIALVATLGRLGPISPAVSVVPSILAKFSTVVNPVIYMFFNNQ 0
0 FYRCFMAFVRCQKEPESIQGE* 0
>TMTc_oryLat Oryzias latipes (medaka) Deut.Acti.Perc genomic full G? ciliary uropsin syn(+SLC9A7 +FHL1 +GPR56 +TMTx -ARGHGEF7 -RBMX)
0 MVLHSHNCNFSTKDSSPCSTNSTEPHNPDGLSRTGHTAVAVCLGFILVAGILNNFLTLLVFAKFRSLWTPINLILLNISLSDILVCVLGTPFSFAASVRGRWLIGESGCKWYAFANSLF 1
2 GIVSLVSLSVLSYERYITVLHSSQADLSNFRKAWFCVGGSWLYSLLWTLPPFLGWSSYGPEGPGTTCSIQWHLRSPTSVSYVLCLFIFCLVLPLVLMVYSYGRILVALRR 0
0 VGKINLLAAQRREQRILVMVFSMVSCYILCWMPYGIVALMATFGRKGLVTPLTSVIPSILAKFSTVVNPVIYVFFNSQ 0
0 FYRCLVAFVRCSGDPEEHPTPRTQLSDVVRVQKQNSVSSSSPRLLSDPTDRMLCNHHPDRHVLFVHYTP* 0
>TMTa_oncMyk Oncorhynchus mykiss (trout) Deut.Acti.Salm CU062745 full G? teleost multiple tissue testis new
0 MVVESGNLNFSTDDSSGTNLSPKDSVRDTLTSRQSDLGRTGHTVVAVFLGVIFLLGFLSNLFVLLVFARFQVLRTPINLILLNISVSDMLVCIFGTPFSFAASLYGRWLIGAHGCKWYGFANSLF 1
2 GIVSLVSLAILSYERYSTILCYTKADPSDYKKAWLAIAGAWLYSLVWTVPPFFGWSSYGPEGPGTTCSVQWHQRSSGNISYVTCLFIFCLLLPLLLMMFCYGKILFAIRG 0
0 VAKINQSSAQRRETHVLVMVVSMVSCYLLCWMPYGVVALLATFGQVGLVSPTTSIVPSILAKSSTFLNPVIYGLLNNQ 0
0 FYRCFLAFMSCGSEAAGSHTLHTLPSSRVVGPYGNSPAPEEPGTREPLDGSGTSSKTQTRGPQREKRDLVLVVHYTP* 0
>TMTa_anoCar Anolis carolinensis (lizard) Deut.Saur.Lepi genomic full G? teleost multiple tissue
0 MTVPSISPSCIGVANGVWCSNGGSSSNSHHRHGQEQSLSPTGHLITAICLGVIGSLGFLNNLLVLVLFCRNKVLRSPINLLLMNISLSDLMICIVGTPFSFAASTQGKWLIGPAGCVWYGFANTFF 1
2 GTVSLISLAVLSYERYCTMMGTTEADATNYKKVWMGIFLSWIYSLFWSLPPLFGWSSYGPEGPGTTCSVNWHSRDANNISYIICLFIFCLVIPFIVIVYCYGKLLCAIKK 0
0 VSGVTQGMAQTREQRVLIMVVVMIICFLLCWLPYGIVALIATFGKPGLITPSASIIPSVLAKSSTVYNPVIYIFLNKQ 0
0 FYRCFCALLKCGKKSIASSNKCSSRSTRVCRSIRKQDNFTFVAASAGPPSSEHQDAILSIQNPEPPTDNSPKAKQRVLLVAHYSV* 0
>TMTa_xenTro Xenopus tropicalis (frog) Deut.Amph.Anur genomic full G? teleost multiple tissue scaffold_55
0 MAFHSSSPSCSDSSSVTCRSSIQQYGPENHPNLSPTGHLLVAVFLGVIGSLGFFNNLVVLILFCQYKVLRSPINMLLMNISLSDLMVCILGTPFSFAASTQGHWLIGEIGCIWYGFVNTLF 1
2 GTVSLVSLAVLSYERYCTMLRSTEADLTNYKKAWLGILVSWIYSLVWTLPPLFGWSKYGPEGPGTTCSVNWHSRDANNISYIVCLFIFCLALPFAVIVYCYGRLLFAIKQ 0
0 VSGVSKSSSRAREQRVLIMVIVMVVCFLLCWLPYGVMALVATFGKPGIISPSASIIPSVLAKSSTVYNPIIYIFLNKQ 0
0 FYRCFTALIHCNKHPQVSSNKGSSKTTKIMLTARKLPDANFTVNAASNPPSSSVVKYEADSKTHNGDTKPFKTLVANYVI* 0
>TMTa1_danRer Danio rerio (zebrafish) Deut.Acti.Otoc AF349947 12670711 full G? teleost multiple tissue syn(+PBX3 +TNK2 +TMTa1 -PAP2D +LPPR4)
0 MIVSNLSVLSCRRNSALCLGAVEGHLEASSSYRTLSPTGHILVAVSLGFIGTFGFLNNLLVLVLFGRYKVLRSPINFLLVNICLSDLLVCVLGTPFSFAASTQGRWLIGDTGCVWYGFANSLL 1
2 GIVSLISLAVLSYERYCTMMGSTEADATNYKKVIGGVLMSWIYSLIWTLPPLFGWSRYGPEGPGTTCSVDWTTKTANNISYIICLFIFCLIVPFLVIIFCYGKLLHAIKQ 0
0 VSSVNTSVSRKREHRVLLMVITMVVFYLLCWLPYGIMALLATFGAPGLVTAEASIVPSILAKSSTVINPVIYIFMNKQ 0
0 FYRCFRALLNCDKPQRGSSLKSSSKTKPFRPGRRTDNFTFMVASVGPNQTNPVEDGPPSADNTKPAVLSLVAHYNG* 0
>TMTa_takRub Takifugu rubripes (fugu) Deut.Acti.Perc AF402774 12670711 full G? teleost multiple tissue syn(-CALD1 +TNK2 -RAB18 +ABI1 12670711)
0 MIVSNVSLSGCAGVNGAVCAAEGHQAGGSDRSTLTPTGNLVVSVFLGFIGTFGLVNNLLVLVLFCRYKMLRSPINLLLMNISISDLLVCVLGTPFSFAASTQGRWLIGEAGCVWYGFANSLF 1
2 GVVSLISLAVLSFERYSTMMTPTEADPSNYCKVCLGITLSWVYSLVWTVPPLFGWSSYGPEGPGTTCSVNWTAKTTNSISYIICLFVFCLIVPFLVIVFCYGKLLCAIRQ 0
0 VSGINASTSRKREQRVLCMVVIMVICYLLCWLPYGVVALLATFGPPDLVTPEASIIPSVLAKSSTVINPIIYVFMNKQ 0
0 FYRCFLALLCCQDPRSGSSMKSSSKVATKAKGVTPTGQRRTDFLYMVASLGRPAATIPQLGPSFDATNDFTKPPSSDTIKPVVVSLAAHCDG* 0
>TMTa_tetNig Tetraodon nigroviridis (pufferfish) Deut.Acti.Perc genomic full G? teleost multiple tissue
0 MIASNASVSGCAGVHGAACAADAPPAGGSHRSSSSLTPTGNLVVSVFLGLIGTSGLVSNLLVLVLFCRFKVLRSPINLLLVNISVSDLLVCVLGTPFSFAASTQGRWLIGAAGCVWYGFVNSLF 1
2 GIVSLISLAVLSFERYSTMMTPTEADSSNYCKVCLGIGLSWVYSLLWTVPPLLGWSSYGPEGPGTTCSVNWTAKTANSVSYIICLFVFCLILPFLVIVFCYGKLLCAIRQ 0
0 VSGVNASMSRRREQRVLFMVVVMVICYLLCWLPYGVVALLATFGPPGLVTPAASIIPSILAKSSTVINPVIYVFMNKQ 0
0 FSRCFLSLLCCEDPRSSTSLRSSSRVTTKAVRGGTLTGQRRTNHLLYMVAALGRPVATAMPQLGPSFDATYDITKAPSSDNHQPVVVSLEAHG* 0
>TMTa_gasAcu Gasterosteus aculeatus (stickleback) Deut.Acti.Perc genomic full G? teleost multiple tissue syn(+TNK2 +ENC)
0 MIVSNLSLSGCAGVSSALCAAAGEGHLSGGSHRNTLTPTGHLVVAVCLGFIGTLGLMNNLLVLVLFCRYKMLRSPINLLLINISISDLLVCVLGTPFSFAASTQGRWLIGEGGCVWYGFANSLF 1
2 GIVSLISLAVLSYERYSTMVAPTEADSSNYHKISLGITLSWVYSLIWTAPPLFGWSHYGPEGPGTTCSVDWTARTANSISYIICLFVFCLIVPFLVIVFCYGKLLCAIRQ 0
0 VSGINASLSRKREQRVLFMVVIMVVCYLLCWLPYGIMALMATFGPPGLITPVASIIPSVLAKTSTVINPVIYVFMNKQ 0
0 FYRCFKALLRCEAPRPSSSLKSSSKVPTKAMRGAAVTGPRHTNNFLFVVASLGRPVATIPQLGPSVEPTIDVTGGPSSDNNKPVIVSLVAQCDG* 0
>TMTa_oryLat Oryzias latipes (medaka) Deut.Acti.Perc genomic frag G? teleost multiple tissue syn(SLC12A3) two contigs frag
0 MLVSNVSLGGCAEFNSALCAGAGEEHLGGGSYRTTLTPTGHLIVAVCLGFIGTFGLVNNLLVLVLFCRYKILRSPINLLLINISISDLLVCVLGTPFSFAASTQGRWLIGEGGCVWYGFANSLC 1
2 GIVSLISLAVLSYERYSTMMTPAEADSSNYRKISLGIILSWGYSLLWTLPPLFGWSHYGPEGPGTTCSVDWTAKTANNISYIICLFVFCLIVPFMVIVFCYGKLLYAIKQ 0
0 VSGINVSVSRKREQRVLFMVVIMVICYLLCWLPYGIMALLATFGPPDLVTPEASIIPSVLAKTSTAINPVIYVFMNKQ 0
>TMTa_pimPro Pimephales promelas (minnow) Deut.Acti.Otoc DT200813 frag G? teleost multiple tissue
0  GHLVVAVCLGFIGTfGFLNNTLVLILFCRYKVLRSPMNYLLVSIAVSDLLVCVLGTPFSFAASTQGRWLIGRAGCVWYGFINSCL 1
2 GVVSLISLAVLSYERYCTMMGATQADSTNYKKVAMGIAFSWIYSMVWTLPPLFGWSCYGPEGPGTTCSVNWAARTANNVSYIICLFFFCLILPFIVIVYSYGRLLQAITQ 0
0 VSRINTVVSRKREQRVLFMVITMVVCYLLCWLPYGIMALLAAFGRPGLVTPAASIVPSVLAKTSTVINPIIYIFMNKQ 0
0 FCRCFHALIMCTTPQRGSSFKNSSKVTKTLRTVRRANGQNVTFAVASAGHPTICAPH
>TMTc_danRer Danio rerio (zebrafish) Deut.Acti.Otoc CO927631 full G? teleost multiple tissue syn(+TNK1 +TMTb -MYEOV2)
0 MIESNVSRSCEWCAGGGEGTGAHLDENHSDHSLSPTGHLVVAVCLGFIGTFGFLNNTLVLVLFCRYKVLRSPMNCLLISISVSDLLVCVLGTPFSFAASTQGRWLIGRAGCVWYGFINSFL 1
2 GVVSLISLAVLSYERYCTMMGSTQADSTNYRKVVIGIAFSWIYSMVWTLPPLFGWSCYGPEGPGTTCSVNWAARTPNNVSYIVCLFVFCLILPFIVIVYSYGRLLQAITQ 0
0 VSRINTVVSRKREQRVLFMVVTMVVCYLLCWLPYGIMALLATFGHPGLVTPAASIVPSLLAKSSTVINPIIYIFMNKQ
0 FCRCFHALIMCTTPERGSSFKNSSKVTKTLRTVRRANGQNVTFAVASAVHRTPYSDRQKSSSEGEKLPPATGQGTSKPVVSLVAYYNG* 0
>TMTb_takRub Takifugu rubripes (fugu) Deut.Acti.Perc genomic full G? teleost multiple tissue syn(+TFRC +TMTb +CHES1 -MYEOV2 -ARHGAP21)
0 MIVCNVSLSCAHCPGEGTAANDAYAQASGSLATPTLSQRGHLVVAVCLGFIGTVGFLSNFLVLALFCRYRALRTPMNLMLVSISASDLLVSVLGTPFSFAASTQGRWLIGRAGCVWYGFVNACL 1
2 GIVSLISLAVLSYERYCTMVSSTIASNRDYRPVLGGICFSWFYSLAWTVPPLLGWSRYGPEGPGTTCSVDWRTQTPNNISYIVCLFTFCLLLPFFVILYSYGKLLHTIRQ 0
0 VRRVSSTVTRRREHRVLVMVVAMVVCYLICWLPYGVTALLATFGPPNLLTPEATITPSLLAKFSTVINPFIYIFMNKQ 0
0 FYRCFRAFLNCSTPKRDSTVRTFTRISLRALRQDQQQKGSALAPSSARPTPNSIHESSLKGSHSTPSNGGAAAAKSPAANRSKPKLILVAHYRE* 0
>TMTb_tetNig Tetraodon nigroviridis (pufferfish) Deut.Acti.Perc genomic full G? teleost multiple tissue
0 MIVCNLSLSCAHCPGGGAAATDAYAYAEAPGSLAPPTLSQRGHLVVAVCLGAIGTVGFLSNLLVLALFCRFRALRTPMNLMLVSISASDLLVSVLGTPFSFAASTQGRWLLGRAGCVWYGFVNACL 1
2 GIVSLISLAVLSYERYCTMMASTMASNRDYRPVLLGICFSWFYSLAWTVPPLLGWSRYGPEGPGTTCSVDWRTQTPNNISYIVCLFAFCLLLPFCVILYSYGKLLHTIRQ 0
0 VSSVSSAVTRRREHRVLVMVVAMVVCYLICWLPYGVTALLATFGPPNLLTPEATITPSLLAKFSTVINPFIYIFMNKQ 0
0 FYRCFRAFLSCSSPERGSTVRTFTRISLRAVCQRKQQRVSAPAASSACPTPNSIHHSSRKGSHSASSNSGTAAAAKTPAANSSKPKLILVVHYRE* 0
>TMTb_gasAcu Gasterosteus aculeatus (stickleback) Deut.Acti.Perc genomic full G? teleost multiple tissue
0 MIVCNVSLSCVHCPGGGAGGTAATATGAYEEVSDSLPAPSLSPKGHLVVAVCLGFIGTFGFLSNFLVLALFCRYRALRTPMNLLLVSISASDLLVSMVGTPFSFAASTQGRWLIGRAGCVWYGFVNACL 1
2 GIVSLISLAVLSFERYSTMVKPTVADGRDFRPALGGIAFSWLYSVAWTVPPLLGWSEYGPEGPGTTCSVDWKTQTANNISYIVCLFVFCLVLPFCVILYSYSRLLQAIRQ 0
0 VSVVSSVVTRHREQRVLAMVVVMVACYLVCWLPYGVAALLATFGPRDLLSPEASITPSLLAKFSTVVNPFIYIFMNKQ 0
0 FYRCFRAFLSCSTPERGSTLKTFSRPTKTLRAGRHEKGRRVSAAAPSTAQPTRNSAPRSSQGANHASATPPPSPADGRCAAAGAAKPKRTLVAHYRE* 0
>TMTb_oryLat Oryzias latipes (medaka) Deut.Acti.Perc genomic full G? teleost multiple tissue
0 MIVPNASLSCAHCDGDAAEQDAPGSAAAPSLSPTGHLVVAVCLGLIGTCGFLSNLLVLALFCRYRALRTPMNLLLVSISVSDLLVSVLGTPFSFAASTQGRWLIGRAGCVWYGFINACL 1
2 GIVSLISLAVLSYERYSTVMTPNMADGRDFRPALGGICFSWLYSVAWTVPPLLGWSRYGPEGPGTTCSVDWKTQTPNNISYIICLFTFCLLLPFGVIVYSYGKMLRVIRQ 0
0 VRSMSSVVTRRREQRVLVMVVTMVVCYLVCWLPYGIAALLATFGPRDLLTPAASITPSLLAKFSTVINPLIYIFMNKQ 0
0 FYRCFWAFFCCSTPEQVSTLRTFSRVTKTIRTFRQERELHVSAPAPSSGLPTPNSIQKGNNHVDPSSINQACAASDSPDSRKPKVVLVAHYQE* 0
>TMTa1_calMil Callorhinchus milii (elephantfish) Deut.Chon.Holo genomic frag G? teleost multiple tissue exons 1,2,3
0 MLNSSPNSSPSLPLSQVGWTGLSRTGLTVVAVCLGIIMVLGFLNNLLVLVLFCKYKVLRSPMNMLLLNISVSDMLVCICGTPFSFAASVQGRWLVGEQGCKWYGFANSLF 1
2 GIVSLMSLTILSYDRYITITGTTEADITNYNKTIVGIALSWIYSLMWTLPPLFGWSNYGPEGPGTTCSVNWQSKEVSSKSYIICLFIFCLLMPFLVIVYCYGKLVLAVRK 0
0 VSANNSMGRTRENKLLIMVTFMIICFLLCWLPYGIVALLATFGSPGLITPTASIIPSVLAKTSTVYNPIIYIFMNKQ 0
>TMTa2_calMil Callorhinchus milii (elephantfish) Deut.Chon.Holo genomic frag G? teleost multiple tissue exons 1 and 3
0 MMAHSANISTTLNASDHAPNLAGLSQSGHTTVAVFLGIILVLGCVNNLLVLLLFVCFKEIRTPLNMILLNISLSDLSVCVFGTPFSFAASIYRRWLIGHKGCKWYGFANSLF 1
0 VGKINQMTAQTREHRILLMVISMVTFYLLCWLPYGTVALIGTFGNADLITPTCSVIPSILAKSSTVINPVIYVIMNKQ 0
>TMTx_braFlo Branchiostoma floridae (amphioxus) Deut.Ceph.Bran XM_002207814 frag G? assembly duplication no N-term even in v2
0 VAAILALIGVLGIVNNSTTLYLVGRYKQLRTPFNILMVNLSVSDLLMCVLGTPFSFVSSLHGRWMFGHSGCEWYGFICNFL 1
2 GIVSLITLTVISYERYLLMKRLPNERILSYRAVALAVVFIWCYSLLWTAPPLVGWSSYGPE 0
0 GYGISCSVNWESRTANDTSYIVAYFVGCLVFPVAIIVISYTRLILYMRQ 0
0 APSAPMQMLVRREKRVTKMVVVMIMGFTICWTPYTIVALIVTCGGEGIITPAAATVPALFAKSSVVYNAAIYVAMNNQ 0
0 FRKCFLRSLNCRSQPRDPSSQQYTLKTNQVGMSTSGSQAARTADRIKTVHVATANPQDHRSSSGQAVEDNGGFRKSLTHSLPLNSISTLLEAEK* 0
>TMTy_braFlo Branchiostoma floridae (amphioxus) Deut.Ceph.Bran FE572481 full G? teleost multiple tissue gastrula XM_002222645 flawed allele dup new
0 MASAGQNVTFPAIDTMAPTPEALTSDPTTPAYFTTEQHLLMAVWLGFIGSFGFVTNLLTVLVFWCFKSLRTPFHLYLGGIALSDLLVAALGSPFAVASAVGERWLFGRAVCVWYAFVNYFL 1
2 SIVSIVTMATMSFSRYWVIIRPQSAPRLDTVYGACVVNALAWCYSFFWTIMPVLGWSRFTQ 0
0 VAAMTVCSLDWDHHTPLSKSYIPVAFLTCLFLPLGVIIFSVFKTTMHLRR 0
0 AAEVEDEVPNEVRAGRKTTRITLVMAGCWLVAWLPYACMALVIAAGGRVSPTVEVLATKFAKTSYIVNTIIYLVMEKE 0
0 FRKSLVLLLFCGRDPFDIQIEQPAYEKADVYVERLVTAEPMVEMEAVNVRPAQQEPARAPFGTPL* 0
>TMT1_strPur Strongylocentrotus purpuratus (sea_urchin) Deut.Echi.Eleu XM_001177470 16311335 full G? teleost multiple tissue PIN-type introns no cdna no sacKow
0 MSNLMTGLVTNVNALSGIGNETPTTIGLSSLVVPVSRTTYNYLTVYTGFLTIFGILNNGIVMILFARFPSLRHPINSFLFNVSLSDLIISCLASPFTFASNFAGRWLFGDLGCTLYAFLVFVA 1
2 GTEQIVILAALSIQRCMLVVRPFTAQKMTHRWALFFISLTWIYSLIICVPPLFGWNRYTYEGPGT 1
2 ACSVAWNSPSPGDTSYIIFIFVLVLVIPFGIIIFCYGLLVYAVKK 0
0 ISRTQAALSSEAKADRKVSKMIFIMILFFLIAWTPYTGFSLYVTFGKNVVITPLAGTFPPFFAKLCTIHNPIIYFLLNKQ 0
0 FKDALIQLFCCGENPFDRDESEHEGRGGRHRHRTAPSATAHIGGRGRASSLPTATSMLDIPQAASTAASSSGKTQNKESLEKGPSTSETTNKRVFELSSKIQKFEISEKNNTPSSSELPGASSLSGALMPPRRAMKNQVGCLPPVDN* 0</font>
<font color ="#0066CC">>TMT1_plaDum Platynereis dumerilii (ragworm) Ecdy.Anne.Poly CT030681 16311335 full G? 5 exons
0 MDDLGFLGNSSVNYTVPLLQEDPLLLRILYFGPTSYVITAIYLCIVGVIGTLSNGVIMYLYFKDKSLRSPMNLLFVNLAMSDFTVAFFGAMFQFGLTCTRKYMSPGMALCDFYGFITFLG 1
2 GLASEMNLFIISVERYLAVVRPFDVGNLTNRRVIAGG 1
2 VFVWLYSLVFAGGPLVGWSSYRPEGLGTWCSISWQDRSMNTMSYVTAVFLGCYFFPVSIIIFCYFNVWRKVKE 0
0 AADAQGGAGTAGKAEKSIFRMSVIMVTCYLTAWTPYAIVCLIASYGPPNGLPIYAEVLPSLFAKSSQVYNPIIYVLMNKP 0
0 YRSALVSLVCRGRNPFDEAGGTAGGTTAKDETLGKGNKVAAA* 0
>TMT2_plaDum Platynereis dumerilii (ragworm) Ecdy.Anne.Poly AY692353 15514158 full G? new genomic
0 MDGENLTIPNPVTELMDTPINSTYFQNLNAETDGGNHYIYNAFTATDYNICAAYLFFIACLGVSLNVLVLVLFIKDRKLRSPNNFLYVSLALGDLLVAVFGTAFKFIITARKTLLREEDGFCKWYGFITYLG 1
2 GLAALMTLSVIAFVRCLAVLRLGSFTGLTTRMGVAAMA 1
2 FIWIYSLAFTLAPLLGWNHYIPEGLATWCSIDWLSDETSDKSYVFAIFIFCFLVPVLIIVVSYGLIYDKVRK 0
0 VAKTGGSVAKAEREVLRMTLLMVSLFMLAWSPYAVICMLASFGPKDLLHPVATVIPAMFAKSSTMYNPLIYVFMNKQ 0
0 FRRSLKVLLGMGVEDLNSESERATGGTATNQVAAT* 0
>TMT_terTra Terebratalia transversa (lampshell) Loph.Brac.Rhyn HQ679623 full 21362157
MSTASSGTVTTVMESNITTLSPFTTRAPMFSDGANVIIVLVLFVTAILGFFMNGSVLIIFYRKKELRSPTNMFIISMAFNDLMMSILGNPFAAVSNLHHR
WIFGDAACVWYGFIMFFLGLNGIYHLTAIAFDRYIVIAKPLLSSKITTRVAALAISVCWFGAFLWSVFPVFGWSSYVEEGEHSSCSINWISQSIVDSSYI
ISIFIFCFFLPILLVIFSYFHVYMTVRTIAKSNTFGKDSKITKKNEAVERKMAKMVIIMITVFFGSWSPYAIVSMFVAFGDGSSLPAAAIAAPAIIAKSA
MIWNPIIYVLMNVQFRSGFAEMYPCFAVCANTDGGKVKVERPPTVQDNIGDDNTEMSDVRSAVPPAPTSNILKVAPAPDTTKADVHTSETGEQSIAMSIA
RMSVRHKVESRTPVEQMNAVEV*</font>
<font color ="#6699FF">>TMT1_anoGam Anopheles gambiae (mosquito) Ecdy.Inse.Dipt XM_312503 full G? GPROP11 pteropsin GPROP11 head-to-head tandem GPROP12
0 MYDVTDAAAINSDHQELMAPWAYNGAAVTLFFIGFFGFFLNIFVIALMYKDVQ 0
0 LWTPMNIILFNLVCSDFSVSIIGNPLTLTSAISHRWLYGKSICVAYGFFMSLL 1
2 GIASITTLTVLSYERFCLISRPFAAQNRSKQGACLAVLFIWSYSFALTSPPLFGWGAYVNEAANIS 2
1 CSVNWESQTANATSYIIFLFIFGLILPLAVIIYSYINIVLEMRK 0
0 NSARVGRVNRAERRVTSMVAVMIVAFMVAWTPYAIFALIEQFGPPELIGPGLAVLPALVAKSSICYNPIIYVGMNTQ FRAAFWRIRRSNGVAGQPDSNNTNNSNRDKESARHTAKEGL
ECSLDFCHWTVRGTRVSISSAERNVPAPAARERSGGHSVTGSREESRDRHVTLKTMLSVGPRSPSSVAPVAADCSTTDVPTSGDGSVRIVRQDSELSVIHDGGGGGGGSSSRVLVIKSQKPRSNML* 0
>TMT2_anoGam Anopheles gambiae (mosquito) Ecdy.Inse.Dipt XM_312502 full G? GPROP12 pteropsin encephalopsin GPROP12
0 MNDAPNDVAASAVDYEDLMAPWAYNASAVTLFFIGFFGFFLNLFVIALMCKDMQ 0
0 LWTPMNIILFNLVCSDFSVSIIGNPLTLTSAISHRWIFGRTLCVAYGFFMSLL 1
2 GITSITTLTVLSYERYCLISRPFSSRNLTRRGAFLAIFFIWGYSFALTSPPLFGWGAYVQEAANIS 2
1 CSVNWESQTKNATTYIIFLFVFGLVVPLIVIVYSYTNIIVNMRE 0
0 NSARVGRINRAEQRVTSMVAVMIVAFMVAWTPYAIFALIEQFGPPELIGPGLAVLPALVAKSSICYNPIIYVGMNTQ FRAAFSRVRNKGQQAAADQNTTTMQRELTKSSRDMVECSF
DFCRKKSRFKISLVKPTAPLAVVDVSSTSHRDKGTSRSPLDQTVLNETNEDVGRERSGGGGGGGAYAGTRFVRPDFELSVINSGKSILIKSKNFRSNLL* 0
>TMT_aedAeg Aedes aegypti (mosquito) Ecdy.Inse.Dipt XM_001650752 full G? pteropsin genome frameshifted
0 MESWAYVASAVTLFFIGFFGFFLNLFVIALMCKDVQ 0
0 LWTPINIILFNLVCSDFSVSIIGNPFTLTSAISRHWIFGRTVCIAYGFFMSLL 1
2 GITSITTLTVLSYERFCLISHPFSSRSLSRRGAVFAILFIWSYSFALTSPPLFGWGAYVNEAANIS 2
1 CSVNWESQTLNATSYIIFLFVFGLVVPLVVIVYSYTNIVVNMKR 0
0 NAARVGRINRAEKRVTRMVFVMVLAFMIAWTPYAVFALIEQFGPTDIISPALGVLPALIAKSSICYNPIIYVGMNTQFRAAFNRVRNNESVDNNTITNQKDITMNTSK
EIVECSFDFCRKKRLKIKLQSNAKSKNNNNNSRNQSIADPSSTSNGDDLDQPSPAQTVLNSTVANSGSVASFGPKKRLRSDFELSVISSGKSILIKSNTFRSNLV* 0
>TMT_culPip Culex pipiens (mosquito) Ecdy.Inse.Dipt genomic full G? pteropsin
0 MPPWAYVATAVVLFFIGFFGFFLNLFVIALMCKEVQ 0
0 LWTPMNIILLNLVCSDFSVSIVGNPFTLSSAISHRWLFGRKLCVAYGFFMSLL 1
2 GITSITTLTVLSYERFYLISRPFSSRSLSRRGALGAVLLIWCYSFALTSPPLFGWGAYVNEAANIS 2
1 CSVNWETQTLNATTYIIYLFVFGLVVPLTVIVYSYTNIIVNMKK 0
0 NAARVGRINRAEKRVTTMVAVMVIAFMVAWTPYSVFALMEQFGPPDVIGPGLAVLPALIAKSSICYNPIIYVGMNTQFRAAFNRVRHDPGDMANTTTNQKELT
RSSRDVASVDCSFDFCRKKNRLKMKLHNSIHRSAAIKAGRSQSPHSESERSSSGATQERSTRVQTMLNATVDSRSISGSTGKLMKSDFELSVINSGKSILIKSNTFRSNLV* 0
>TMT_triCas Tribolium castaneum (flour_beetle) Ecdy.Inse.Cole genomic full G? pteropsin
0 MKNFNSTEIGDELLIPVEGYIAAAVVLFCIGFFGFSLNLTVIIFMLKERQ 0
0 LWSPLNIILFNLVVSDFLVSVLGNPWTFFSAINYGWIFGETGCTIYGFIMSLL 1
2 SITSITTLTVLAFERYLLIARPFRNNALNFHSAALSVFSIWLYSLSLTIPPLIGWGEYVHEAANLS 2
1 CSVNWEEKSPNSTSYILYLFAFGLFLPLVIITFSYVNIILTMRR 0
0 NAAFRVGQVSKAENKVAYMIFIMIIAFLTAWSPYAIMALIVQFGDAALVTPGMAVIPALLAKSSICYNPVIYIGLNAQVKGAKWVSGLIYLFQFQQAWMQKWKKNRR
GSDALGTSRVMLETIHQACRDEKTDKLLEKKTKFCKDFETDVSML* 0
>TMT_apiMel Apis mellifera (bee) Ecdy.Inse.Hyme NM_001039968 16291092 full G? AmLop2 pteropsin ciliary compound eye not ocelli clock
0 MSLNRSTMEHVIYEDQVSPVMYIGAAIALGFIGFFGFTANLLVAIVIVKDAQILWTPVNVILFNLV 0
0 FGDFLVSIFGNPVAMVSAATGGWYWGYKMCLW 2
1 YAWFMSTLGFASIGNLTVMAVERWLLVARPMQALSIR 2
1 HAVILASFVWIYALSLSLPPLFGWGSYGPEAGNVSCSVSWEVHDPVTNSDTYIGFLFVLGLIVPVFTIVSSYAAIVLTLKKVRKRA 1
2 GASGRREAKITKMVALMITAFLLAWSPYAALAIAAQYFN 0
0 AKPSATVAVLPALLAKSSICYNPIIYAGLNNQFSRFLKKIFDARGSRTAVPDSQHTALTALNRQEQRK* 0
>TMT_bomTer Bombus terrestris (bumblebee) Ecdy.Inse.Hyme 454SRA full G? pteropsin presumed ciliary compound eye not ocelli clock
0 MSLNRSTVDNVVYDAEDQVSPMVYVAAAIALGFIGFFGFTMNLLVAIVIVKDAQILWTPVNVILVNLV 0
0 VGDFLVAAFGNPVAMISAITGGWYWSYEMCLW 2
1 YAWFMSTLGFASIGNLTVMAVERWLLVARPMKALSIR 2
1 HAITLGIFVWFYALCLSLPPLFGWGSYGPEAGNVSCSVSWEVHDPLTKSDSYIAFLFVFGLIIPVLVISSSYVAIIVTLRKVRKRA 1
2 GASGRREAKITKMVALMITAFLLAWSPYAALAIAAQYFD 0
0 AKPSASVAVLPALLAKSSICYNPIIYAGLNSQFPRSLKKIFDVRIARSSLPDSQNTALTLLNRQEQRN* 0
>TMT_attCep Atta cephalotes (ant) Ecdy.Inse.Hyme wgs ADTU01001608 full 63% bee
0 MSLNLSVEEQLSIDIYIFAAIALGFIGFL 21 GFFLNLLVIITVLKNANVLWTPNNVVLINMV 0
0 IGDFLVAALGNPFTMTSAIAGEWFWSHEVCLW 2
1 YAWFMTTMGFASIGNLTVMAMERFLLVTCPMKTLSIR 2
1 HAYILAILVWMYALSLSLPPFFNWGIYGPEAGNISCSVSWEIHDPYMHNDTYIGFLFIVGFFLPVTIIISSYYGIIKTLRKIRKRV 1
2 GAKNRREKKVTKMVYLMILAFLIAWSPYAVLALATQYFYV 0
0 QTSHILAVLPALLAKSSICYNPIIYASMTAQFPTWKKMFSINRNNTKSKQRHGSELQIK* 0
 
>TMT_rhoPro Rhodnius prolixus (kissing_bug) Ecdy.Inse.Hemi ACPB01038515 full G? pteropsin ACPB01038514
0 MLMPSAGFLAASIILFLIGFLGFFGNLIVIIIMCRDKN 0
0 LWTPVNFILFNVIVSDFSVAALGNPFTLASAIAKRWFFGQSMCVAYGFFMALL 1
2 GITSINSLTVLALERYLIVSQPVSHGSLSRPTASDIVGSIWLYSFVITiPPLVGWGEYGLEAANIS 2
1 CSINWETRSHSSTSYILFLFTFGFFIPIIVISYSYMNIILTMKK 0
0 STMNAGRVNKAESRVTWMIFVMIFAFFLAWTPYAILALMIAFFDSNVSPAIATIPAIFAKTSICYNPFIYAGLNTQ 0
0 FRQSWRRVLGGKREDSTTMATATSFGLNSKRYKEVSCVIDVKGKDKIKLSALNKSTATETAI* 0
>TMT_acyPis Acyrthosiphon pisum (aphid) Ecdy.Inse.Hemi genomic full G? pteropsin two contigs, 1st exon very wrong in XM_001952259
0 MNGEYAQPQHISDAIYLGAAIVLSIIGIVGFIFNTCVIFIMIRDTR 0
0 LWTPQNVIIFNLATSDLAVSVLGNPVTLAAAITKGWIFGQTICVIYGFFMALF 1
2 GIASITTLTVLAYDRYLMIRYPFSSSRLTKETALYAIAGIWIYAFAVTGPPLFGWNRYVNESANIS 2
1 CSIDWESGEHSNYVIYIFVFGLFLPVTVIIYSYVSLVVTVRK 0
0 AEKIIGQATKAECRVAIMVAVMILAFLTAWMPYSVLALMIAFGGVHISPVVSIIPALCAKSSICWNPIIYIGLNTQ 0
0 FRSAWKRFLNIQDTLSEVSLDADITTGMTKLMTGHQELPAHPMNNGDASHPPGLIMCCLAHDEHRQSATYADRYECNLEMKSCNPQTLGRRPETDIGDVSL* 0
   
   
Thus there is no evidence whatsoever -- and every reason to doubt from genomic analysis -- that deuterostomes had imaging eyes during the Cambrian. Despite this, a BBC series, Walking With Monsters, portrayed a school of 25 mm Haikouichthys attacking and wounding a 500 mm Anomalocaris. It is easy to guess at the scientific advisory panel. [This recurrent anthropocentric theme is echoed by fantastic museum imagery of early mammals nimbly predating on dinosaur nests -- dioramas quietly dismantled after Yucatan meteriorite discovery.] Imaging eyes are not essential to survival; even today subterranean mammals such as blind mole rat flourish without them. Discounting ray-finned fish numbers, a very substantial proportion of extant animal species lack imaging eyes 525 myr after the Cambrian. Of 33 animal phyla, a one-third have no specialized organ for detecting light, one-third have light-sensitive organs, and the remaining 6 have imaging eyes (Cnidaria, Mollusca, Annelida, Onychophora, Arthropoda, and Chordata). Thus 82% of animal phyla have survived well over 500 myr without imaging eyes despite competition/predation from animals with them.  
>TMT_bomMor Bombyx mori (moth) Ecdy.Inse.Lepi BY930435 frag G? ovary cDNA
 
0 MPRWGYVASAFVLFLIGFFGFFLNLMVILLMFKDRQ 0
>RHO1_homSap rhodopsin                <----------TM1--------->    c1    <----------TM2------->    x1      <c--i------TM3--------->          c2      <----------TM4-------->              x2        <----------TM5------c->    c3
0 LWTPLNIILFNLVCSDFSVSVLGNPFTLISALFHRWIFGHTMCVLYGFFMALL 1
MNGTEGPNFYVPFSNATGVVRSPFEYPQYYLAEPWQFSMLAAYMFLLIVLGFPINFLTLYVTVQHKKLRTPLNYILLNLAVADLFMVLGGFTSTLYTSLHGYFVFGPTGCNLEGFFATLGGEIALWSLVVLAIERYVVVCKPMSNFRFGENHAIMGVAFTWVMALACAAPPLAGWSRYIPEGLQCSCGIDYYTLKPEVNNESFVIYMFVVHFTIPMIIIFFCYGQLVFTVKE
  2 GITSITTLTVISFERYLMVTRPLTSRHLSSKGAVLSIMFIWTYSLALTTPPLLGWGNYVNEAANIQ 2
AAAQQQESATTQKAEKEVTRMVIIMVIAFLICWVPYASVAFYIFTHQGSNFGPIFMTIPAFFAKSAAIYNPVIYIMMNKQFRNCMLTTICCGKNPLGDDEASATVSKTETSQVAPA* 0
  1 CSVNWHEQSTNTLTYIMFLFAMGQILPLSVITFSYVNIIRTLKR 0
          c3      <----------TM6------->    x3      <--------b-TM7---gprot> helix8    palm cyto tail
0 NSQRLGRVSRAEARATAMVFIMIIAFTVAWTPYSLFALMEQFATEGI 0
 
0 VSPGASVIPALVAKSSICYDPLIYVGMNTQ 0
  urochordate (1?), Cathaymyrus (cepahochordate, 1)
0 FR
 
lungfish opsins> Neoceratodus can't find it ... have to query with rhodopsin as ncbi tool is too stupid.
 
did find doubly partial seq
 
>RHO1_Protopterus lungfish doubly partial seq
LAEPWKYSALAAYMFFLILVGFPINFMTLYVTIQHKKLRTPLNYILLNLAIGGLFMVFGGFTTTMYTSMNGYFVFGVTGCNIEGFFATFGGILGLWSLVV
LAIERYIVVCKPMSNFRFGENHAIMGIVFTWIMTLACAAPPLFGWSRYIPEGMQCSCGIDYYTLKPEVNNESFVIYMFVVHFLIPLIIIFFCYGRLVCTV
KEAAAQQQESATTQKAEKEVTRMVYIMVISFLVCWLPYAFVAFYIFTHKGSDFGPVFMTAPAFFAKTAAFYNPVIYIFMNKQ 0
0 FRNCM      *0
    
    
>TMT_helVir Heliothis virescens (moth) Ecdy.Inse.Lepi GR968759 frag G? pteropsin pheromone gland
0 MPRWGYVVSAFVLFLIGFFGFFLNLMVILLMFKDRQ 0
0 LWTPLNIILFNLVCSDFSVSVLGNPFTLISALFHRWIFGKTMCVLYGFFMALL 1
2 GITSITTLTVISFERYMMVTRPLNSRHLSSKGAIMSIVF
>TMTa_dapPul Daphnia pulex (water_flea) Ecdy.Crus.Bran genomic full G? pteropsin retained intron?
0 MPVWVYWSASAYLLFISIAGLFMNIVVVVIILNDSQ 0
0 KMTPLNWMLLNLACSDGAIAGFG 2
1 TPISAAAALKFTWPFSHELCVAYAMIMSTA 1
2 GIGSITTLTVLALWRCQHVVWCPTNRNSNFTDPNGRLDRRQGALLLTFIWTYTLIVTCPPLFGWGRYDREAAHIS 2
1 CSVNWESKMDNNRSYILYMFAMGLFIPLMAIFVSYISILLFIHK 0
0 SQQTSNNSDTVEKRVTFMVAVMIGAFLTAWTPYSIMALVETFTGDNVTNDSVSSEIKFYAGTISPAVATVPSLFAKTSAVLNPLIYGLLNTQ 0
0 FRTAWEKFSSRFLGRKKRHQRSQMAMGVSHKRRRDYLRTLLNRPASDEPAIVQHPSTKEMASSQAVSCVVVSNLDVPRAPNNSYVTVNDE* 0
>TMTb_dapPul Daphnia pulex (water_flea) Ecdy.Crus.Bran genomic full G? pteropsin long tail IGQDNHSTYYSSRINNATNFSSAFPDGDLSY intron?
0 MPTWAYRLTAAYLLLISVLGLIMNVVVVIVILNDSQ 0
0 RMTPLNWMLLNLACSDGAIAGFG 2
1 TPISTAAALEFGWPFSQELCVAYAMIMSTA 1
2 GIGSITTLTALAIWRCQLVVCCPAKRKSAFTNHSGRLGCRQGVILLVIIWIYALAITCPPLFGWGRYDREAAHIs 2
1 CSVNWESKTNNNRSYILYMFCMGLVVPLAVIIISYVRILRVVQK 0
0 NQQQSGNVHRHRRDAAEKRVTMMVACMIAAFMAAWTPYSILALFETFIGQDNHSTYYSSRINNATNFSSAFPDGDLSYVGTISPAFATIPSLFAKTSAVLNPLIYGLLNTQ 0
0 FRLAWERFSLRFLGRFQCHRTQGVSGQHGANHHKTRRNVRKYLPNCYGDSRSLKPTPTVHLPMKEMVVSHAEQKVKTAQEQASSSVTKITTIPLISSDNQTIVSCPSSIMAN
CQQHETNQANHQQAARPDKVVDHQHLLQPNRLSSLLSLSLPSVLISTPNLPCSAQRQSAAEDQAMATCQQMTSGRIRDQQQQSDSFVVVGLLSRSADCYHHHTGDVEQFVFLDSTVDELGLTARSASP* 0</font>
<font color ="#990099">>MEL1_homSap Homo sapiens (human) Deut.Euth.Euar NM_033282 full Gq OPN4 melanopsin syn(-GRID1 -WAPAL +LDB3 +BMPR1A)
0 MNPPSGPRVPPSPTQEPSCMATPAPPSWWDSSQSSISSLGRLPSISPT 0
0 APGTWAAAWVPLPTVDVPDHAHYTLGTVILLVGLTGMLGNLTVIYTFCR 2
1 SRSLRTPANMFIINLAVSDFLMSFTQAPVFFTSSLYKQWLFGET 1
2 GCEFYAFCGALFGISSMITLTAIALDRYLVITRPLATFGVASKRRAAFVLLGVWLYALAWSLPPFFGW 1
2 SAYVPEGLLTSCSWDYMSFTPAVRAYTMLLCCFVFFLPLLIIIYCYIFIFRAIRETGR 2
1 ALQTFGACKGNGESLWQRQRLQSECKMAKIMLLVILLFVLSWAPYSAVALVAFAG 2
1 YAHVLTPYMSSVPAVIAKASAIHNPIIYAITHPKYR 2
1 VAIAQHLPCLGVLLGVSRRHSRPYPSYRSTHRSTLTSHTSNLSWISIRRRQESLGSESEV 0
0 GWTHMEAAAVWGAAQQANGRSLYGQGLEDLEAKAPPRPQGHEAETPGK 0
0 TKGLIPSQDPRM* 0
>MEL1_panTro Pan troglodytes (chimpanzee) Deut.Euth.Euar genomic full G? OPN4 melanopsin
0 MNPPSGPRVPPSPTQEPSCMATPAPPSWWDSSQSSISSLGRLPSISPT 0
0 APGTWAAAWVPLPTVDVPDHAHYTLGTVILLVGLTGMLGNLTVIYTFCR 2
1 SRSLRTPANMFIINLAVSDFLMSFTQAPVFFTSSLYKQWLFGET 1
2 GCEFYAFCGALFGISSMITLTAIALDRYLVITRPLATFGVASKRRAAFVLLGVWLYALAWSLPPFFGW 1
2 SAYVPEGLLTSCSWDYMSFTPAVRAYTMLLCCFVFFLPLLIIIYCYIFIFRAIRETGR 2
1 ALQTFGACKGNGESLWQRQRLQSECKMAKIMLLVILLFVLSWAPYSAVALVAFAG 2
1 YAHVLTPYMSSVPAVIAKASAIHNPIIYAITHPKYR 2
1 VAIAQHLPCLGVLLGVSRRHSRPYPSYRSTHRSTLISHTSNLSWISIRRRQESLGSESEV 0
0 GWTHMEAAAVWGAAQQANGRSLYGQGLEDLEAKAPPRPQGHEAETPGK 0
0 TKGLIPSQDPRM* 0
>MEL1_gorGor Gorilla gorilla (gorilla) Deut.Euth.Euar genomic full G? OPN4 melanopsin
0 MNPPSGPRVPPSPTQEPSCMATPAPPSWWDSSQSSISSLGRLPSISPT 0
0 APGTWAAAWVPLPTVDVPDHAHYTLGTVILLVGLTGMLGNLTVIYTFCR 2
1 SRSLRTPXNMFIINLAVSDFLMSFTQAPVFFTSSLYKQWLFGET 1
2 GCEFYAFCGALFGISSMITLXAIALDRYLVITRPLATFGVASKRRAAFVLLGVWLYALAWSLPPFFGW 1
2 SAyVPEGLLTSCSWDYMSFTPAVRAYTMLLCCFVFFLPLLIIIYCYIFIFRAIRETGR 2
1 ALQTFGACKGNGESLWQRQRLQSECKMAKIMLLVILLFVLSWAPYSAVALVAFAG 2
1 YAHVLTPYMSSVPaVIAKAsAIHNPIIYAITHPKYR 2
1 VAIAQHLPCLGVLLGVSRRHSRPYPSYRSTHRSTLISHTSNLSWISIRRRQESLGSESEV 0
0 GWTHMEAAAVWGAAQQANGRSLYGQGLEDLEAKAPPRPQGHEAETPGK 0
0 TKGLIPSQDPRM* 0
>MEL1_ponAbe Pongo abelii (orangutan) Deut.Euth.Euar genomic full G? OPN4 melanopsin
0 MNPPSGPRVPPSPTQEPSCMATPAPPSWWDSSQSSISSLGQLPSISPT 0
0 APGTWAAALVPFPTVDVPDHAHYTLGTVILLVGLTGMLGNLMVIYTFCR 2
1 SRGLRTPANMFIINLAVSDFLMSFTQAPVFFTSSLYKQWLFGET 1
2 GCEFYAFCGALFGISSMITLTAIALDRYLVITRPLATIGVASKRRAAFVLLGVWLYALAWSLPPFFGW 1
2 SAYVPEGLLTSCSWDYMSFTPAVRAYTMLLCCFVFFLPLLIIIYCYIFIFRAIRETGR 2
1 ALQTFGACKGNGESLWQRQRLQSECKMAKIMLLVILLFVLSWAPYSAVALVAFAG 2
1 YAHVLTPYMSSVPAVIAKASAIHNPIIYAITHPKYR 2
1 VAIAQHLPCLGVLLGVSRRHSRPYPSYRSTHRSTMISHTSNLSWISGRRRQESLGSESEV 0
0 GWTHMEAAAVWGAAQQANGRFLYDQGLEDLEAKAPPRPQGEEAETPGK 0
0 TKGLIPSQDPRM* 0
>MEL1_rheMac Rhesus macaca (rhesus) Deut.Euth.Euar genomic full G? OPN4 melanopsin fill-in traces
0 MNPPSGPRVPPSPTQEPSCMATPAPPSRWDSSQSSISSLGQLPSVSPT 0
0 AAGTWAAAWVPFPTVDVPDHAHYTLGTVILLVGLTGMLGNLTVIYTFCR 2
1 SRGLRTPANMFIINLAISDFLMSFTQAPVFFASSLYKHWLFGET 1
2 GCEFYAFCGALFGISSMITLTAIALDRYLVITRPLATIGVASKRRAAFVLLGVWLYALAWSLPPFFGW 1
2 SAYVPEGLLTSCSWDYMSFTPAVRAYTMLLCCFVFFLPLLIIIYCYIFIFRAIRETGr 2
1 ALQTFGACKGSGESLWQRQRLQSECKMAKIMLLVILLFVLSWAPYSAVALVAFAG 2
1 YAHVLTPYMSSVPAVIAKASAIHNPIIYAITHPKYR 2
1 VAIAQHLPCLGVLLGVSRRHSHPYPSYRSTHRSTLISHTSNLSWISGRRRQESLGSESEV 0
0 GWTHMEAAAVWGAAQQANGRSLYGQGLEDLEAKAPPRPQGQEAETPGK 0
0 TKGLLPCKDSRM* 0
>MEL1_calJac Callithrix jacchus (marmoset) Deut.Euth.Euar genomic full G? OPN4 melanopsin fill-in traces
0 MNLPTGSRVLPSPTQEPSCMTTPAPPSRWDSSQSSISSLSQLPSISPT 0
0 AAGTWAAAWIPFPTVDVPDHAHYTLGTVILLVGVTGMLGNLTVIYTFCR 2
1 SRGLRTPANMFIINLAVSDFLMSFTQAPVFFASSLYKRWLFGET 1
2 GCEFYAFCGALFGISSMITLMAIALDRYLVITRPLATIGVASTKRAAFVLLGVWLYALAWSLPPFFGW 1
2 SAYVPEGLLTSCSWDYMSFTPAVRAYTMLLCCFVFFLPLLIIIYCYIFIFRAIRETGR 2
1 ALQTFGACKGSGESLWQRQRLQSECKMAKIMLLVILLFVLSWAPYSAVALVAFAG 2
1 YAHVLTPYMSSVPAVIAKASAIHNPIIYAITHPKYR 2
1 VAIAQHLPCLGVLLGVSRRHSHPYPSYRSTHRSTLISHTSNLSWISGRRRQESLGSESEV 0
0 GWTHMEAAAAWGAAQQANGRSLYGHGLEDLEAKAPPRPQRQEAETPGK 0
0 tkGLLPSLDARW* 0
>MEL1_micMur Microcebus murinus (mouse_lemur) Deut.Euth.Euar genomic full G? OPN4 melanopsin fill-in traces 4aa del exon 9 confirmed
0 MNPPSGPRMPPSPAQEPSCVATPALASSGDSSQNSVSSLGQLLPASPT 0
0 ATGAWAAAWVPFPTADVPDHAHYTLGTVILLVGLTGMLGNLTVIYTFCr 2
1 SRSLRTPANMFVINLAVSDFLMSVTQAPVFFASSLYKRWLFGEA 1
2 gCEFYAFCGALFGISSMITLTAIALDRYLVITRPLASVGTASKRRAGLVLLGVWLYALAWSLPPFFGW 1
2 SAYVPEGLLTSCSWDYMTFTPSVRAYTMLLCCFVFFLPLLVIIYCYIFIFRAIRETGR 2
1 ALQTFGASKGTSESPRQQQRLQNEWKMAKIMLLVILLFLLSWAPYTAVALVAFAG 2
1 YAHILTPYMNSVPAVIAKASAIHNPIIYAITHPKYR 2
1 VAIAQHLPCVGVLLGVSRQHSRPYPSYRSTHRSTLSSQASDLSWISGRRRQESLGSENDM 0
0 GWTDMEVAAAWGAAPRVRGRCPYGQGPEDMEVKV QGQEAETPGK 0
0 AEGLPPCMDPRM* 0
>MEL1_otoGar Otolemur garnettii (lemur) Deut.Euth.Euar genomic full G? OPN4 melanopsin fill-in traces
0 mnLPSAPRVPPSPAQASSCVATPAPHSRWDSSQTSISSLGQLRPVSPT 0
0 ASGAWAAGWIPFPTVDVPDHAHYTLGTVILLVGLTGMLGNLTVIYTFCR 2
1 VRGLRTPANMFVINLAVSDFLMSVTQAPVFFASSLYKQWLFGET 1
2 GCEFYAFCGALFGISSMITLTAIALDRYLVITRPLTTVGVASKRRAALVLLGVWLYSLAWSLPPFFGW 1
2 SAYVPEGLLTSCSWDYTSFTPSVRTYTMLLCCFVFFLPLLIIIYCYIFIFRAIRETGR 2
1 ALQTFGACKGSSESPRQRQRLQNEWKMAKITLLVILFFVLSWAPYTTVALVAFAG 2
1 YAHVLTPYMNSVPAVIAKASAIHNPIIYAITHPKYR 2
1 VAIAQHLPCLGLLLGVSRQHSRPYPSYRFTHHSTLSSQASDLSWISGRRRQESLGSESEV 0
0 GWTDMEAAATWGAALQVSGQCPYSQGLEDMEAKGPLRPQGPETKTSGK 0
0 TKGLLPSLDPRM* 0
>MEL1_musMus Mus musculus (mouse) Deut.Euth.Euar AF147789 10632589 full G? OPN4 melanopsin GenBank wrong readthru
0 MDSPSGPRVLSSLTQDPSFTTSPALQGIWNGTQNVSVRAQLLSVSPT 0
0 TSAHQAAAWVPFPTVDVPDHAHYTLGTVILLVGLTGMLGNLTVIYTFCR 2
1 NRGLRTPANMFIINLAVSDFLMSVTQAPVFFASSLYKKWLFGET 1
2 GCEFYAFCGAVFGITSMITLTAIAMDRYLVITRPLATIGRGSKRRTALVLLGVWLYALAWSLPPFFGW 1
2 SAYVPEGLLTSCSWDYMTFTPQVRAYTMLLFCFVFFLPLLIIIFCYIFIFRAIRETGR 2
1 ACEGCGESPLRQRRQWQRLQSEWKMAKVALIVILLFVLSWAPYSTVALVAFAG 2
1 YSHILTPYMSSVPAVIAKASAIHNPIIYAITHPKYR 2
1 VAIAQHLPCLGVLLGVSGQRSHPSLSYRSTHRSTLSSQSSDLSWISGRKRQESLGSESEV 0
0 GWTDTETTAAWGAAQQASGQSFCSQNLEDGELKASSSPQVQRSKTPK 0
0 TKGHLPSLDLGM* 0
>MEL1_ratNor Rattus norvegicus (rat) Deut.Euth.Euar AY072689 11834834 full G? OPN4 melanopsin
0 MNSPSESRVPSSLTQDPSFTASPALLQGIWNSTQNISVRVQLLSVSPT 0
0 TPGLQAAAWVPFPTVDVPDHAHYTLGTVILLVGLTGMLGNLTVIYTFCR 2
1 NRGLRTPANMLIINLAVSDFLMSFTQAPVFFASSLYKKWLFGET 1
2 GCKFYAFCGAVFGIVSMITLTAIAMDRYLVITRPLATIGMRSKRRTALVLLGVWLYALAWSLPPFFGW 1
2 SAYVPEGLLTSCSWDYVTFTPLVRAYTMLLFCFVFFLPLLIIIFCYIFIFRAIRETGR 2
1 ACEGCGESPLRRRQWQRLQSEWKMAKVALIVILLFVLSWAPYSTVALVGFAG 2
1 YSHILTPYMSSVPAVIAKASAIHNPIIYAITHPKYR 2
1 AAIAQHLPCLGVLLGVSGQRSHPSLSYRSTHRSTLSSQSSDLSWISGQKRQESLGSESEV 0
0 GWTDTETTAAWGAAQQASGQSFCSHDLEDGEVKAPSSPQEQKSKTPK 0
0 TKRHLPSLDRRM* 0
>MEL1_nanEhr Nannospalax ehrenbergi (molerat) Deut.Euth.Euar AM748539 full G? OPN4 melanopsin
0 MNSPSGPRVPPGLAQKPSFMVTPVLPNQWISFQKNVSVGIQLPPASAT 0
0 ATGAQAASWVPFPTVDVPVHAHYTLGTVILLVGLTGMLGNLIVIYTFCR 2
1 SRGLRTRANMFTVNLAVSDFLMSFTQAPVFFASSLYKRWLFGEA 2
2 GCEFYAFCGAVSGITSMTTLTAIALDRYLVITRPLATIGVASKRRTALVLLGVWLYALAWSLPPFFGW 1
2 SAYVPEGLLTSCSWDYMTFTPSVRAYTMLLFCFVFFLPLLIIIFCYIFIFKAIRETGR 2
1 ACEGCGESPQRRRQWQRLQNEWKMAKVALLVIFLFVLSWAPYSTVALVAFAG 2
1 YSHILTPYMNSVPAVIAKASAIHNPIIYAITHPKYR 2
1 LAISQHLPCLGVLIGVSSQRSHPSLSYRSTHRSTLSSQASDLSWISGRKRQESLGSESEV 0
0 GWTDTEVTAAWGVAQEASGWSPYRHSLEDGEVKASPSPQGQEAKTSR 0
0 TKGQLPSLNLRM* 0
>MEL1_phoSun Phodopus sungorus (hamster) Deut.Euth.Euar AY726733 15698924 frag G? OPN4 melanopsin 3D ends in error: AKGQLPSLDLGMQDAP
0 MDSPPGPTAPPGLTQGPSFMASTTLHSHWNSTQKVSTRAQLLAVSPT 0
0 ASGPEAAAWVPFPTVDVPDHAHYILGTVILLVGLTGMLGNLTVIYTFCR 2
1 SRSLRTPANMLIINLAVSDFLMSFTQAPVFFASSLYKKWLFGET 2
1 GCEFYAFCGAVLGITSMITLTAIALDRYLVITRPLATIGMGSKRRTALVLLGIWLYALAWSLPPFFGW 1
2 SAYVPEGLLTSCSWDYVTFTPQVRAYTMLLFCFVFFLPLLVIIFCYISIFRAIRETGR 2
1 ACEGWSESPQRRRQWHRLQSEWKMAKVALIVILLFVLSWAPYSTVALVAFAG 2
1 YSHILTPYMSSVPAVIAKASAIHNPIVYAITHPKYR 2
1 AAIAQHLPCLGVLLGVSSQRNRPSLSYRSTHRSTLSSQSSDLSWISAPKRQESLGSESEV 0
0 GWTDTEATAVWGAAQPASGQSSCGQNLEDGMVKAPSSPQ
0 * 0
>MEL1_bosTau Bos taurus (cow) Deut.Euth.Laur genomic full G? OPN4 melanopsin
0 MNPPSGPRAPLGPVQESSCLATPASSSRWDSSRSSASSLGHPPSISPT 0
0 AVRAQAAAWVPFPTVDVPDHAHYTLGTVILLVGLTGMLGNLTVIYTFCR 2
1 SRGLRTPANMFIINLAVSDFLMSFTQAPVFFASSLYKQWLFGEA 1
2 GCEFYAFCGALFGITSMITLTAIALDRYLVITRPLATVGMVSKRRAALVLLGVWLYALAWSLPPFFGW 1
2 SAYVPEGLLTSCSWDYVSFTPSVRAYTMLLFCFVFFLPLLIIIYCYIFIFKAIRETGQ 2
1 ALQTFGTCEGGSECPRQRQRLQNEWKMAKIELLVILLFVLSWAPYSTVALMGFAG 2
1 YAHILTPYMNSVPAVIAKASAIYNPIIYAITHPKYR 2
1 LAIAQHLPCLGVLLGVSGQRTGLYTSYRSTHRSTLSSQASDLSWISGRRRQASLGSESEV 0
0 GWMDTEATAAWGAGQQVSGWSPCSQRLDDVEAKALPRPQGRDSEAPGK 0
0 AKGLLPNLDARM* 0
>MEL1_susScr Sus scrofa (pig) Deut.Euth.Laur genomic full G? OPN4 melanopsin
0 MNPPSRPSAPPDPALESSCMATPASPSRWDSSQSSTSSLGHPLPISPT 0
0 AARVRAAAWVPFPTVDVPDHAHYTLGTVILLVGLTGMLGNLTVIYTFCR 2
1 SRGLRTPANMFIINLAVSDFLMSFTQAPVFFASSLYKQWLFGEA 2
1 GCEFYAFCGAVFGITSMITLTAIALDRYLVITHPLATVGMVSKRRAALVLLGVWLYALAWSLPPFFGW 1
2 SAYVPEGLLTSCSWDYVSFTPKVRAYTMLLFCFVFLLPLLVIIYSYIFIFKAIRETGQ 2
1 ALQTFGACERRGKCPRQRQRLQNEWKMAKIELLVILLFVLSWAPYSTVALMGFAG 2
1 YGHVLTPYVNSVPAVIAKASAIYNPIIYAITHPKYR 2
1 MAIAQHLPCLGVLLGVSGQRTGLYTSYRSTHRSTLSSQASDLSWISGRRRQASLGSESEV 0
0 GWTDTEATAAWGAAQQVSRWSPCGQGLEDMEAKTSLGRLGWEAEAPGK 0
0 TKGLLPSLDPRM* 0
>MEL1_equCab Equus caballus (horse) Deut.Euth.Laur genomic full G? OPN4 melanopsin bad GenBank
0 MNPPSEPQVPLGLAQEPGCVATPASPSRWSGSRSSTSSLGQPLPVGPT 0
0 AAGAQADAWVPFPTVDVPDHAHYTMGTVILLVGLTGMLGNLTVIYTFCR 2
1 SRGLRTPANMFIINLAVSDFLMSFTQAPVFFASSLYKQWLFGKA 1
1 GCEFYAFCGALFGITSMITLTAIALDRYLVITRPLATVGVVSKRWAALVLLGIWLYALAWSLPPFFGW 1
2 SAYVPEGLLTSCSWDYMTFTPSVRAYTMLLMCFVFFLPLLVIVYCYVFIFRAIRETGR 2
1 ALQTFGAWEGGGECPRQRQRLQSEWKMAKIVLLVILLFVLSWAPYSVVALVAFAG 2
1 YAHVLTPYMNSVPAVIAKASAIHNPIIYAIIHPKYR 2
1 MAIAQHLPCLGVLLGVSSQRTRPYTSYRSTHRSTLSSQGSDLSWISGRRRQASLGSESEV 0
0 GWMDTEAAAVWGAAQQMSGWSPCGQGLEDMEAKAPPRPQGWEGEALRK 0
0 IKGLLPSLDPRM* 0
>MEL1_felCat Felis catus (cat) Deut.Euth.Laur AY382594 15842746 full G? OPN4 melanopsin wrong readthru
0 MNPPSGPRTQEPSCVATPASPSRWDGYRSSTSSLDQPLPISPT 0
0 AARAQAAAWIPFPTVDVPDHAHYTLGTVILLVGLTGILGNLMVIYTFCR 2
1 SRGLRTPANMFIINLAVSDFFMSFTQAPVFFASSLHKRWLFGEA 1
2 GCEFYAFCGALFGITSMITLMAIALDRYLVITHPLATIGVVSKRRAALVLLGVWLYALAWSLPPFFGW 1
2 SAYVPEGLLTSCSWDYMSFTPSVRAYTMLLFCFVFFLPLLVIVYCYIFIFRAIRETGQ 2
1 ALQTFRACEGGGRSPRQRQRLQREWKMAKIELLVILLFVLSWAPYSIVALMAFAG 2
1 YAHVLTPYMNSVPAVIAKASAIHNPIIYAITHPKYR 2
1 MAIAQHLPCLGVLLGVSGQHTGPYASYRSTHRSTLSSQASDLSWISGRRRQASLGSESEV 0
0 GWMDTEAAAVWGAAQQVSGRFPCSQGLEDREAKAPVRPQGREAETPGQ 0
0 TKGLLPSQDPRM* 0
>MEL1_canFam Canis familiaris (dog) Deut.Euth.Laur genomic full G? OPN4 melanopsin fixed 44-way
0 MNPPSGPGAQEPGCVATAASPGRWHGSPRSTVGLDQALPTGPT 0
0 AAGARAAAWAPFPTVDVPDHAHYILGTVILLVGLTGMLGNLMVIYTFCR 2
1 TRGLRTPSNMFIINLAVSDFFMSFTQAPVFFASSLHKRWLFGEA 1
2 GCEFYAFCGALFGITSMITLTAIALDRYLVITHPLAAVGVVSKRRAALVLLGVWLYALAWSLPPFFGW 1
2 SAYVPEGLLTSCSWDYMSFTPSVRAYTMLLFCFVFFLPLLVIVYCYVFIFRAIRETGQ 2
1 ALQTFRACEGGARSPRQRQRLQREWKMAKMELLVILLFVLSWAPYSAVALTAFAG 2
1 YSHVLTPYMNSVPAVIAKASAIHNPIIYAITHPKYR 2
1 MAIAQHLPCLGVLLGVSGQRTGPYASYRSTHRSTLSSQASDLSWISGRRRQASLGSESEV 0
0 GWMDTEAAAVWGAAQPAGGRFLCTQGLEDAEAKAPLRPRGQAVETPGK 0
0 TKGRLPSLDPSRE* 0
>MEL1_myoLuc Myotis lucifugus (microbat) Deut.Euth.Laur genomic full G? OPN4 melanopsin 7 aa del in exon 1 confirmed 1 aa del in DRY cyto loop
0 MNPPSGPRGPLDPAREPGCVATPVSP SSTSSVDPPLPTSPT 0
0 AAEAQAAAWVSFPTVDVPAHAHYTLGIVILLVGLTGMLGNLTVIYTFCR 2
1 SRGLRTPANMFIINLAVSDFLMCFTQAPVVFASSIYKRWLFGEA 1
2 GCEFYAFCGALFGITSMITLTAIALDRYLVITRPL AIGVVSKRRAALVLLGVWLYALAWSLPPFFGW 1
2 SAYVPEGLLTSCSWDYMSFTPAVRSYTMLLFCFVFFLPLLVIIYCYVFIFRAIRETGQ 2
1 ALQTFGACEGRSELPRQRQGLQNEWKMAKIVLLVILLFVLSWAPYSTVALMAFAG 2
1 YAHVLTPYMNSVPAIIAKASAIHNPIIYAITHPKYR 2
1 MAIAQHLPCLGLLLGVSGQRTGPYASYRSTHRSTLSSQASDLSWVSRRRRQESLGSESEM 0
0 GWTDTEAAAMWGAAQQVSGPPPCSQGLEDVETKAPPKSQGHEAEDPRK 0
0 TKGLLPSPDPRM* 0
>MEL1_pteVam Pteropus vampyrus (macrobat) Deut.Euth.Laur genomic full G? OPN4 melanopsin
0 MNLPVGPRVPLDPAQEPSCMATPASPS WDSSPSSASSLDQPLPISPT 0
0 AAGSQAAAWVPFPTVDVPDHAHYTLGTVILLVGLTGMLGNLTVIYTFCR 2
1 SRGLRTPANMFIINLAVSDFLMSFTQAPVVFISSLYKRWLFGQA 1
2 GCEFYAFCGALFGITSMITLTAIALDRYLVITRPLAAIGVVSKRRAALVLLGVWLYALAWSLPPFFGW 1
2 SAYVPEGLLTSCSWDYMSFTPSVRAYTMLLFCFVFFLPLLIIIYCYIFIFRAIRETGQ 2
1 ALQTFGACEGLSELPRQRQRLQSEWKMAKIVLLVILLFVLSWAPYSTVALMAFAG 2
1 YSHVLTPYMNSVPAIIAKASAIHNPIIYAITHPKYR 2
1 MAIAQHLPCLGVLLGMSGQHTGPYTSYRSTHRSTLSSQASDLSWISRRRRQASLGSESEM 0
0 GWTDTEAAATWGTAQQVSGPSLWGQDLEDVEAKAPPKPQGREAEAPRK 0
0 TKELLPSLDPRM* 0
>MEL1_eriEur Erinaceus europaeus (hedgehog) Deut.Euth.Laur genomic full G? OPN4 melanopsin
0 MALSLGPRVPTSQALDPSCMDTPASPSRWDSSQNSTSSLAQLPLISLT 0
0 SVSPQATASAPFPTVNVPDHAHYTLGTVILLVGLTGMLGNLTVIYTFCR 2
1 SRSLRTPANMFIINLAVSDFLMSFTQTPVFFASSLYKQWLFGEA 1
2 GCEFYAFCGALFGITSMITLTAIALDRYLVITRPLATIGVVSKRRVALVLLGVWLYSLAWSLPPFFGW 1
2 SAYVPEGLLTSCSWDYMRFTPSFRAYTMLLFCFVFFLPLLVIIYCYIFIFRAIRETGQ 2
1 ALQTFRACEGSCDFPRQQQRLQSEWKMAKIILLVILLFVLSWAPYSTVALMAFAG 2
1 YAHVLTPYMNSVPAVIAKASAIHNPIIYAITHPKYR 2
1 MAIAQHLPCLRVLLGVSGQRDRPYTSYRSTHRSTLSSQISDLSWVSRRRRQASLGSESEV 0
0 GWTDTEVAAVWGT MSGHFPCGQGLDDMEAKAAHNPRGLEAETPGK 0
0 IKGLLPSLDPQM* 0
>MEL1_loxAfr Loxodonta africana (elephant) Deut.Euth.Afro genomic frag G? OPN4 melanopsin
0 MNPPWGPRVPSGRAQEPSCVATPASASRWNSSRASASSLGELPPSSPT 0
0 AARAHTAAWDPFPTVDVPDHAHYTLGAVILLVGLMGMLGNLMVIYIFFR 2
1 SRGLRTPANMFIINLAVSDFLMSFTQAPVFFASSLYKRWLFGEA 1
2 GCKFYAFCGALFGITSMITLTAIALDRYLVITRPLATIGVVSKRRAALVLLGIWLYALAWSLPPFFGW 1
2 SAYVPDGLLTSC 2
1 ALQTFGACEGASEPPRQWQRLQSEWKMAKIALLAILLYVLSWAPYSTVALVAFAG 2
1 YAHVLTPYMNSVPAVIAKASAIHNPIIYAITHPKYR 2
1 MAIAQHLPCLGVMLGVSGQRTRPYTSYHSTLHSTLSSQASDLSWISGRRRQASLGSESEV 0
0 GWTDTEAAAAWEGAQQVSGQASCSQALQNLEANTPPRPQGWGPETPRK 0
0 * 0
>MEL1_proCap Procavia capensis (rock_hyrax) Deut.Euth.Afro genomic full G? OPN4 melanopsin
0 MNPPWGPRVPSRPAQEPSCMSTPASAGRWDSSQATASSLAELPPSSPT 0
0 EARTQTADWVPFPTVDVPDYAHYTLGTVILLVGLTGVLGNLMVIYIFFR 2
1 SRGLRTPANMFIINLAISDFLMSLTQAPVFFASSLYKRWLFGEA 1
2 GCEFYAFCGALFGITSMITLTAIALDRYLVITRPLATIGVVSKRRTALVLLGTWLYALAWSLPPFFGW 1
2 SAYVPDGLLTSCSWDYKSFMPSARTYTMLLCCFVFFLPLLVIIYCYVFIFKAIRETGR 2
1 ALQTFGACEGASETPRQWQRLQSEWKMAKIALLAILLYVLSWAPYSTVALVGFAG 2
1 YAHVLTPYMNSVPAVIAKASAIHNPIIYAITHPKYR 2
1 MAIAQHLPCLGVLLGVSDQHTRPYTSYRSTHHSTLSSQASDISWISGRRRQASLGSESEV 0
0 GWTDTEAAAAWEGAQQVSGRASCSQVLESMEANTPPRPQGWGPETPRK 0
0 VKGLPLLDPRA* 0
>MEL1_echTel Echinops telfairi (hedgehog) Deut.Euth.Laur genomic frag G? OPN4 melanopsin
0 MNLPSGSRVPSGPAQEPSHVATAASASRWNS GSSLDAPPPSSPT 0
0 AARAPTAASAPFPIVDVPDHVHYTLGTVILLVGLTGMLGNLMVIYTFCR 2
1 SRSLRTPANMLIINLAVSDFLMSFTQAPVFFTSSLYKQWLFGEA 1
2 GCEFYAFCGALFGITSMITLTAIALDRYLVITRPLATIGVVSKRRAALVLLVIWLYALAWSLPPFFGW 1
2 SAYVPDGLLTSCSWDYMSFTPSVRAYTMLLFCFVFFLPLLVIIYCYIFIFRAIRETGR 2
1 ALQTFGACEGSRDSPRQRQRLQSEWKMAKIALLVISLFVLSWAPYSTVVLVAFAG 2
1 2
1 0
0 GWTDTEVTATSGYTQQVSGRCPRGQDLESMDANPTPRPRGWETETAQK 0
0 IKGLPLSLNPQA* 0
>MEL1_monDom Monodelphis domestica (opossum) Deut.Meta.Dide genomic full Gq OPN4 melanopsin syn(-GRID1 -WAPAL +LDB3 +BMPR1A)
0 MNPSPMLRGLSCPAQDTNCTKIMASMSEWNNTEEDAYHLVDLPSIAPT 0
0 AVVLPPSSQNIFPTVDVPDHAHYTIGAIILAVGITGMLGNFLVIYTFCR 2
1 SHSLRTPANMFIINLAISDFFMSFTQAPVFFASSMYKRWIFGEK 1
2 ACEFYAFCGALFGITSMITLMAIALDRYFVITRPLASIGVISKKKTGFILLGVWLYSLAWSLPPFFGW 1
2 SAYVPEGLLTSCSWDYTTFTPSVRAYTMLLFCFVFFIPLIVIIYCYIFIFRAIQDTNK 2
1 AVHSIGSGESTASPRHCQRMKNEWKMAKIALVVILLYVLSWAPYSTVALVAFAG 2
1 YSHILTPYMNSVPAIIAKASAIHNPIIYAISHPKYR 2
1 MAIAQNFPCLRALLCVRHPRTRSFSSYRFTRRSTMTSQASDISWLPRGRRQLSLGSESEI 0
0 GWNNMEAGTTSLTSRNQQGSCRMDQETMETRELAAIAKAKGRSWETLEK 0
0 TLEEMDDSSLLEVSVDMEQ* 0
>MEL1_smiCra Sminthopsis crassicaudata (dunnart) Deut.Meta.Dasy DQ383281 17785267 full G? OPN4 melanopsin
0 MNPSPMLRHLSCPAQDSNCTKIMASISEWNNTEVDAYHLVDLPPITPT 0
0 AVVLPPYSQKVFPTADVPDYAHYTIGATILVVGFTGVLGNLLVIYTFCR 2
1 SRSLRTPANMFIINLAISDFFMSFTQAPVFFASSLYERWIFGEK 2
1 GCEFYAFCGALFGITSMITLMVIALDRYFVITRPLASIGMISKKKTGLILLGVWLYSLAWSLPPFFGW 1
2 SAYVPEGLLTSCSWDYTTFTPSVRAYTILLFCFVFFIPLTVIIYCYIFIFRAIKDTNK 2
1 AVQNIGSSEHTPSLRHFQRMKNEWKMAKIALVVILLFVLSWAPYSTVALVAFAG 2
1 YSHVLTPYMNSVPAIIAKASAIHNPIIYAISHPKYR 2
1 MAIAQNFPCLRAVLGIRHPRTQSFSSYRFTHRSTTASQASDISWQSRGRRQLSLGSESEA 0
0 GWNNIETGLTLRSLEGSCGMDEETMDTRELSASTKAKGQSWETLAKTLEE 0
0 MDDLSLLEAGTLLSSLDLQI* 0
>MEL1_ornAna Ornithorhynchus anatinus (platypus) Deut.Prot.Mono genomic frag Gq OPN4 melanopsin
0 0
0 FPTADVPDHAHYTIGATILAVGFTGVLGNLLVIYTFCR 2
1 SRSLRTPANMFIINLSISDFFMSLTQAPVFFASSLHKRWIFGEK 1
2 GCQLYAFCGALFGITSMITLTVIALDRYFVITRPLASIGVISKKRALLILTGVWFYSLAWSLPPFFGW 1
2 sAYVPEGLLTSCSWDYMTFTPPVRAYTMLLFCFVFFIPLIMIIYCYFFIFRAIRGTNK 2
1 AVETIGSDDCRGSQRQCQRMKNEWKTAKIALMVILLYVISWCPYSVVALVAFAG
1 YSHLLTPYMNSVPAVIAKSSAIHNPIIYAITHPKYR 2
1 MAITKYIPCLGPLLRVSRQDSRSSSHYASSRRSTVTSQSLDGSWLPGRRRPLSSASDSES 0
0 0
0 * 0
>MEL1_anoCar Anolis carolinensis (lizard) Deut.Saur.Lepi genomic frag G? OPN4 melanopsin diverged
0 0
0 ERTMFNLPDPFPTVDVPTHAHYTIGAVILVVGITGTLGNLLVIYVFFR 2
1 IRGLRTPANMFVINLAVSDFL 1
2 GCELYAFCGALFGIASMITLTVIALDRYFVITRPLASIGAMSTKKALLILSGVWLYSLAWSLPPFFGW 1
2 sAYVPEGLLTSCSWDYITFTPSVRAYTMLLFCFVFFIPLIAIIYSYVFIFIAIKNSNR 2
1 AVQRTNSDNSKEGQKLYQKLKNEWKMAKVALIVILLVISWSPYSVVALVAFAG 2
1 YSHLLTPYMNSVPAVIAKASVIHNPIIYAIVHPKYR 2
1 MAIAKFLPCLGSLLRVPRKDSSYPSTRRPTVTSQSSDINGVPRGHRRLSSVSDSES 0
0 DWTDTEADISSQNSRVASGSISYRIYEDTTETIKVKSKMRSHDSGIFER 0
0 0
0 TGEDLNAFGWRREESYSGPSTSSQIPSIIVTFSNVQRTDLPLESSSGALCSRNSSYSWEKDSNS* 0
>MEL1_galGal Gallus gallus (chicken) Deut.Saur.Arch AY88294 16856781 full Gq OPN4 melanopsin syn(-GRID1 -WAPAL +LDB3 +BMPR1A) short exon 1
0 MDLPPRAPT 0
0 KMTVKDVRGAFPTVDVPDHAHYTIGTVILIVGITGTLGNFLVIYAFCR 2
1 SRTLQKPANIFIINLAVSDFLMSITQSPVFFTNSLHKRWIFGEK 1
2 GCELYAFCGALFGITSMITLMVIALDRYFVITKPLASVRVMSKKKALIILVGVWLYSLAWSLPPFFGW 1
2 SAYVPEGLLTSCSWDYMTFTPSVRAYTMLLFCFVFFIPLIAIIYSYVFIFEAIKKANK 2
1 SVQTFGCKHGNRELQKQYHRMKNEWKLAKIALIVILLYVISWSPYSVVALVAFAG 2
1 YSHVLTPFMNSVPAVIAKASAIHNPIIYAITHPKYR 2
1 TAIATYVPCLGFLLRVSPKESRSFSSYPSSRRTTITSQSSETSGLQKGKRRLSSISDSES 0
0 GCTDTETDITSMISRPASSQVSYEMGEDTTQTSDLGGKPKVKSHDSGIFRK 0
0 TVVDADEIPMVEINDTEHSATSTCKTSEKCNVEEIQ 0
0 RSESLSGIGLREGESRHRTSASQIPSIIITYSNVQGVELHSGYSAGFLHPKNKSHKQNKSSNS* 0
>MEL1_taeGut Taeniopygia guttata (finch) Deut.Saur.Arch genomic full G? OPN4 melanopsin short exon 1 -GRID1 +LDB3 synteny
0 MDLLLRAPT 0
0 KMTVQDVPRAFPTVDVPDHAHYTIGVVILIVGITGTLGNFLVFYAFCR 2
1 SRSLQTPANILIINLAISDFLMSITQSPVFFTSSLYKHWIFGEK 1
2 GCELYAFCGALFGITSMITLMVIALDRYFVITKPLASVGVTSKKKALIILVGVWLYSLAWSLPPFFGW 1
2 sAYVPEGLLTSCSWDYMTFTPSVRAYTMLLFCFVFFIPLIAIIYSYVSIFEAIKKANK 2
1 SIQTFGCKRGNREFQKQYQRMKNEWKMAKIALIVILFFVISWSPYSVVALVAFAG 2
1 YSHVLTPFMNSIPAVIAKASVIHNPIIYAITHPKYR 2
1 KAIATYVPCLGPLLRVSPKDSRSFSSYHSSRRATISSQSSEISGLQERKRRLSSLSDSES 0
0 GCTETETDTPSMFSRLARRQISYKTDKDTTQTSDIRAKLTSQDSGNCGK 0
0 TAVDADDILMVELNVTEYMATPTVRTILLIFGNKN 0
0 KSESLNSIGQRREFHQGSSSAQIPSITITCSSVQGIELPSRYNSGFLYPKSSSHKQNKKSSS* 0
>MEL1_xenTro Xenopus tropicalis (frog) Deut.Amph.Anur DQ384639 16856781 full Gq OPN4 melanopsin syn(-GRID1 -WAPAL +LDB3 +BMPR1A)
0 MNYQSVRKGITCPPQDANCSRILESLNSWNNSEVNSYKLVELPPIVTT 0
0 ETPQYEIHHVYPTVDVPDHVHYVVGAVILAVGITGMLGNFLVIYAFCR 2
1 SRSLRSPANMFIINLAITDFLMSVTQAPVFFATSLHKRWIFGEK 1
2 GCELYAFCGALFGITSMITLMVIAVDRYFVITRPLTSIGVMSKKRAVLILSGVWLYSLAWSLPPFFGW 1
2 SAYVPEGLLTSCTWDYMTFTPSVRAYTMLLFCFVFFIPLFIIIYCYIFIFKAIKNTNR 2
1 AVQKIGTDNNKESHKQYQKMKNEWKMAKIALIVILLYVVSWSPYSTVALLAFAG 2
1 YASILTPYMNSVPAVIAKASAIHNPIIYAITHPKYR 2
1 MAIAKYIPCLGSLLRVKRRDSRSYSSYPSSRRSTVTSHCSQSSDVGGHPKLKNHLPSVSDSES 0
0 GWTDTEADSSVNSRPASRQVSYEMGKDTTETNDLKSKAKLKSHDSGIFEK 0
0 TSMDADDISLVELGTVDRSSPIM 0
0 ANKHLNGLGQRKGDSFTRRSPSSRIPSIVVTHSNHQGSPAAVRHNSTLPGIKVSNSQDREKELKRQIEKVKQYVPIVTITSDTENSTGGFSNELLPANTS* 0
>MEL1a_danRer Danio rerio (zebrafish) Deut.Acti.Otoc AY078161 12487121 full Gq OPN4 melanopsin syn(- +USP54 +LDB3 +BMPR1A)
0 MMSGAAHSVRKGISCPTQDPNCTRIVESLSAWNDSVMSAYRLVDLPPTTTTTTSVA 0
0 MVEESVYPFPTVDVPDHAHYTIGAVILTVGITGMLGNFLVIYAFSR 2
1 SRTLRTPANLFIINLAITDFLMCATQAPIFFTTSMHKRWIFGEK 1
2 GCELYAFCGALFGICSMITLMVIAVDRYFVITRPLASIGVLSQKRALLILLVAWVYSLGWSLPPFFGW 1
2 SAYVPEGLLTSCTWDYMTFTPSVRAYTMLLFIFVFFIPLIVIIYCYFFIFRSIRTTNE 2
1 AVGKINGDNKRDSMKRFQRLKNEWKMAKIALIVILMYVISWSPYSTVALTAFAG 2
1 YSDFLTPYMNSVPAVIAKASAIHNPIIYAITHPKYR 2
1 LAIAKYIPCLRLLLCVPKRDLHSFHSSLMSTRRSTVTSQSSDMSGRFRRTSTGKSRLSSASDSES 0
0 GWTDTEADLSSMSSRPASRQVSCDISKDTAEMPDFKPCNSSSFKSKLKSHDSGIFEK 0
0 SSSDVDDVSVAGIIQPDRTLTN 0
0 AGDITDVPISRGAIGRIPSIVITSESSSLLPSVRPTYRISRSNVSTVGTNPARRDSRGGVQQGAAHLSNAAETPESGHIDNHRPQYL* 0
>MEL1b_danRer Danio rerio (zebrafish) Deut.Acti.Otoc genomic frag Gq OPN4 melanopsin syn(- +USP54 +LDB3 +BMPR1A)
0 QVAMVQDVRHPFPTVDVPDHAHYTIGSVILAVGITGMVGNLLVMYAFCK 2
1 SRSLRTPANMFIINLAVTDFLMCVTQTPIFFTTSLHKRWIFGEK 1
2 GCELYAFCGALFGICSMITLMIIAVDRYFVITRPLASIGVMSRKRALLILSAAWAYSMGWSLPPFFGW 1
2 SGAYVPEGLLTSCSWDYMTFSPSVRAYTMLLFTFVFFIPLFVIIYCYFFIFKAIRETNR 2
1 AVGKINGEGGPRDSIKKIHRMKNEWKMAKIALIVILLYVISWSPYSCVALTAF 2
1 YADMLTPYMNSVPAVIAKASAIHNPIIYAITHPKYR 2
1 SAIAKYIPCLGVLLCVPRRDRFSSSSFISTRRSTLTSQSSETSSNLHRAGKARLSSVSDSES 0
0 GWTDTEADLSTASSRPASRQVSSEIRKDLCDIKHSSSLRLKVKSRDSGIFDR 0
0 0
0 QNDVSEKADEKRPLVRIPSIIVTSETCPAVLPAGHSSRLIPGAPAVTDS* 0
>MEL1_tetNig Tetraodon nigroviridis (pufferfish) Deut.Acti.Perc genomic full G? OPN4 melanopsin first exon uncertain
0 MGEVGVTVGPACSAAAAYQSGVSCGGELEPSGSAVVMTSLRLAELQLPAST 0
0 LQVAMARPFPTVDVPDHAHYTIGSVILAIGITGMIGNFLVIYAFCR 2
1 SRSLRTPANIFIINLAVADLLMCVTQTPIFFTTSMHKRWIFGEK 1
2 GCELYAFCGALFGICSMITLTVIAIDRYFVITRPLTSIGVLSRKRAFIILMTVWVYSLGWSLPPFFGW 1
2 SAYVPEGLLTSCTWDYMTFTPSVRAYTMLLFIFVFFLPLFIIIFCYIFIFRAIRSTNK 2
1 AVGKVNGSVHSHSRRQESLKKLQRLQSEWRMAKVALIVILLYVISWSPYSCVALTAFAG 2
1 YADMLTPYMNSVPAVIAKASAIHNPIIYAITHPKYR 2
1 LALARYIPCLGLLLCVSPQELRSTSSSFMSMRRSTVTSQTSDISGQFRRQSKPRLSTASDSES 0
0 CLTDTEADLTSTASRPASRQVSCDIGRDTADLPEFQPAASFKSKAKSPDSGVFEK 0
0 TSFDFDASMAAPRQHSSIPN 0
0 NGDFSEGHVTRVALGRIPSIVITSESSFLPHGRKGSASTSAQTATSSDGKAGLG* 0
>MEL1_takRub Takifugu rubripes (fugu) Deut.Acti.Perc genomic full Gq OPN4 melanopsin syn(- +USP54 +LDB3 +BMPR1A)
0 MNFGKSALQPPAQQSVVSCGGGGPEPNCTLRLAVTVMMSVRLAELQLHAST 0
0 LQVAMVRPFPTVDVPDHAHYTIGSVILVIGITGMIGNFLVIYAFCR 2
1 SRSLRTPANMFIINLAVTDLLMCVTQTPIFFTTSMYKRWIFGEK 1
2 GCELYAFCGALFGICSMITLTVIAIDRYFVITRPLTSIGVLSRKRAFVILMTVWIYSLGWSLPPFFGW 1
2 SAYVPEGLLTSCTWDYMTFSPSVRAYTMLLFIFVFFLPLFIIIYCYFFIFRAIRATNK 2
1 AVGKVNGSVHSHSRRRESVKNFQRLQNEWKMAKIALMVILLYVISWSPYSCVALTAFAG 2
1 YADMLTPYMNSVPAVIAKASAIHNPIIYAITHPKYR 2
1 LALAKYIPCLGFLLCISPHELQSTSSSFMSLRRSTVTSQTSDISGQFRPQSKPRRSSASDSES 0
0 CLTDTEADLSSMGSRPASRQVSCDISRDTTELPEYKPASSFNSKVKSPDSGIFEK 0
0 TSFDFDASMAASRERSSIPN 0
0 SGEFPEGHVMRRTLARIPSIIITSESSHFLPNGRKASSTTCIANGSDIKVGPR* 0
>MEL1_gasAcu Gasterosteus aculeatus (stickleback) Deut.Acti.Perc genomic full Gq OPN4 melanopsin syn(- - +LDB3 +BMPR1A)
0 MNAGESELLLPTQQSILPCGDHEPNCPVAQAETLALSAASANGSA 0
0 VQVAMVSRAPHPYPTVDVPDHAHYTIGSVILAIGITGIIGNVLVIYAFSK 2
1 SRSLRTPANMFIINLAITDLLMCVTQAPIFFTTSMHKRWIFGEK 1
2 GCELYAFCGALFGICSMITLTVIALDRYFVITRPLTSIGMMSRRRALLILMGAWTYSLGWSLPPFFGW 1
2 SAYVPEGLLTSCTWDYMTFTPSVRAYTMLLFIFVFFLPLFIIIYCYFFIFRAIRVTNR 2
1 AVGKMNGSIHSHGSGRDSTKNFHRLQNEWKMAKIALIVILLYVVSWSPYSAVALTAFAG 2
1 YADMLTPYMNSVPAVIAKASAIHNPIIYAITHPKYR 2
1 IALAKYIPFLGVLLCVPPRELRSASSSFRSTRRSTVTSQTSDVSSQQRRQGSRNSRLSSASDSES 0
0 CLTDTEADGSSVGSRPASRQVSCDIGRDTAELPEFKPSSSFKSKMKSHDSGIFEK 0
0 SYDTDISMAGVSERGSIPN 0
0 QTDFAEGRDRRSTIGRIPSIVITSETSPFLPTGRNGSCNGRPKTANSSHPGAGSG* 0
>MEL1_oryLat Oryzias latipes (medaka) Deut.Acti.Perc genomic full Gq OPN4 melanopsin syn(- +USP54 +LDB3 +BMPR1A)
0 LQVAMVPQTFHPFPTVDVPDHAHYTIGSVILAIGITGIIGNFLVIYAFSR 2
1 SRSLRTPANMFIINLAITDLLMCVTQSPIFFTTSMHKRWIFGEK 1
2 GCELYAFCGALFGICSMITLTVIAIDRYFVITRPLTSIGVLSRKRALLILSAAWAYSLGWSLPPFFGW 1
2 SAYVPEGLLTSCTWDYMTFTPSVRAYTMLLFIFVFFLPLFIIIYCYVFIFRAIRSTNR 2
1 AVGKINGNTRDAVKSFNRLQNEWKMAKIALIVILLYVISWSPYSTVALTAFAG 2
1 YADMLTPYMNSIPAVIAKASAIHNPIIYAITHPKYR 2
1 MALAKYIPGLGVLLCIHPKDLRSASSSFVSTRRSTVTSQSSDISSQLRRQSTFKSRLSSLSDSES 0
0 GLTDTEADLSSLSSRPASRQVSCEISRDTAELPDFKHTSSFKAKLKNNDSGIFEK 0
0 TSFDTVSIGGVSEHNSIPS 0
0 NRDFGDGNVTRATIGRIPSIVVTSEMSPFLPVGRNGSRTNRSKMANSSAGAGPV* 0
>MEL1a_calMil Callorhinchus milii (elephantfish) Deut.Chon.Holo genomic frag Gq OPN4 melanopsin
0 ASVTDAQHHHMFPTVDVPDHAHYIIGATILAVGVTGMVGNFLVIYAFLR 2
1 SRSLRTPANTFIINLAATDFLMSVTQSPIFFITSIHKRWIFGEK 1
2 GCELYAFCGALFGITSMITLMVIALDRYFVITRPLASIGVLSHRRAGLIILSLWLYSLAWSLPPFFGW 1
2 SAYVPEGLLTSCTWDYMTFTPSVRAYTMLLFCFVFFIPLGVIIYCYIFIFRAIKSTNK 2
1 KVGGSTNRESQKQHQRMKNEWKMAKIALIVILLFVISWSPYSTVALTAFAG 2
1 YADMLTPYMNSVPAVIAKASAIHNPIIYAITHPKYR 2
1 MAIAKYVPLLGLLLRVSRRDSRTSGQYYSTRRSTLTSQTSDLSGYPRGKGRLSSASDSES 0
>MEL1b_calMil Callorhinchus milii (elephantfish) Deut.Chon.Holo genomic frag Gq OPN4 melanopsin based on Squalus
1 SKSLRTPANMFIINLAISDFFMSATQPPVFFVTSLHKRWIFGEK
2 GCKLYAFCGALFGITSMITLMAISIDRYWVITKPLQSISSTTTKKNTLKVIILVWLYSLAWSLPPLLGW 1
>MEL1_petMar Petromyzon marinus (lamprey) Deut.Agna.Hype genomic frag G? OPN4 melanopsin first exon uncertain
0 MAPSIVPLMRKLSCPLSRKTPPKHNVSTSMFDGGDGVLGVIGSIP 0
0 VSFLPSQREKFPMLDIPHHVHHTIGSVVIAIGFTGIIGNFLVIYVFCR 2
0 VQVAMVSRAPHPYPTVDVPDHAHYTIGSVILAIGITGIIGNVLVIYAFSK 2
1 SKSLRSPANIFIINLAFADFFMSITQTPIFFVTSLHKRWIFGEK 1
2 GCELYAFCGALFGIASMVTLMVIATDRYLVLTRPLASIGAMSKRRAMYITAAVWFYSLAWSLPPFFGW 1
2 SAYVPEGLMTSCTWDYVTFTPAVRSYTMLLFCFVFFIPLIVIIFCYVRIFAAIKNTNR 2
1 AVKTLGDAHDSKESQKQQQRMNAEWKLAKIALIVILLYVVSWSPYSCVALVAWAG 2
1 YADMLTPYMNSVPAIIAKASAIHNPIVYAITHPKYR 2
>MEL1_cioInt Ciona intestinalis (tunicate) Deut.Uroc.Tuni AABS01000008 frag G? OPN4 melanopsin transcripts BW447434 BW019524 BW048729 rough seq
0 DRRYPSCYKGEQVTFIYLIPIFLFRTLAFLSSVFVTMTPSAVLPLVTTEARPVHPINDVAMYTFGGLMLTAGTVAVVGNIMVMYTFLRR 0
1 PLHWFIVQLAVADFFVGLIVLWIGTFSSLFLDTVSLMSGIATYGVLAAATSTSTLGVLFIAVDRHFYILRHRRYKQIMTRLRVGTAIVVACVVPATFFVVVPAFGWN 1
2 PEYIEEPLIPSCIFDRFTNSLSNRLYIITMCTFVFFIPLVFICYCLYRIFWAVKSSS 0
2 SLSRAGSRKSQSSGKLSKSNSSRSKRGIQTIEFQILKSAVLLVVLFVSSWMPFTVAAIISIGSNQVSPYVILVSYLFAKASCVHSSFAYITNAHFRATIGLIRCKHTHRA* 0
>MEL1_cioSav Ciona savignyi (tunicate) Deut.Uroc.Tuni AABS01000008 frag G? OPN4 melanopsin 0 transcripts rough
FTTLATLAVIPPTMVLNNSTHPIKVSALLAFGSLMLCAGIIAIVGNLVVMYTFLRPLNWFILQLAVADFFVGLIVLWIGVFSSLLL
ETVSLMSGVATYGVLAAATSTSTLGVLFIAVDRHFYILKHRRYKSIMTRVKVGVAIFFACVTPLAFFVAAPAAGWN 1
DYIAEPLIPSCIFDRFTTSLANQTYIITMCAFVFFVPLLFICYCLVRIYKAVKTSSQTVEFQILKSAVLLMVLFVS
SWMPFTVAAMISVVAEQVDPYVILVSYLFAKASCVHSSFAYITNAHFRATLGVLRCKKRRSV* 0
>MELx_braFlo Branchiostoma floridae (amphioxus) Deut.Ceph.Bran XP_002586120 full Gq
0 MDRMSPNLTNTSLLPNRTDRPELTPADVTMQLVFGSMMLVFGLIGVVGNAVALYAFCS 2
1 TRKLRRPKNYVVANLCLTDLIMCIVYCPVIVISSFSGR 2
1 IPTDGACTMEGFVVGMASIASVGSL 0
0 VAIAVERFFSITRPMKSLTILTKRTFLGGVAVVWLYSLILVIPPLLGWGRYVREETKLSCSFDYLSTDDANRSYVIWLVIVAFGLPLLVIAYCYISVFITVKKCTKKRKLMSPHKKSRSEVKTAVNAFIMTTAFCLCWCPY
AVVATMGISGSSVQGTVVFGAALLAKLSVLINPVAYVFSIPSFRKALFGHRKRGYGTSDGLANDSSSEKRRGKKHESDANSATEYLRLTVFYSMYSRTGQLSPWASKRLAGKTKSMLDLTTEYGRLERTAHKESWV* 0
>MEL_braFlo Branchiostoma floridae (amphioxus) Deut.Ceph.Bran AB205400 15936279 full Gq Amphi-mop 12 exons
0 MTELPSFQPPTNSTEEENAVFPTALTEWISE 0
0 VGNQVGEAALKLLSGEGDGMEVTPTPGCTGNASVCNGTDSGGGVVWDIPPLAHYIVGTAVFCVGCCGMFGNAVVVYSFIK 2
1 SKGLRTPANFFIINLALSDFLMNLTNMPIFAVNSAFQRWLLSDF 1
2 ACELYGFAGGLFGCLSINTLMAISMDRYLVITKPFLVMRIVTKQR 0
0 VMFAILLLWIWSLVWALPPLFGWSAYVPEGF 1
2 GTSCTFDYMTPKLSYHIFTYIIFFTMYFIPMGVIIYCYYNIFATVKSGDKQFGKAVKEMAHEDVKNK 0
0 AQQERQRKNEIKTAKIAFIVITLFLSAWTPYAVVSALGTLGYQDLVTPYLQSIPAVFAKSSAVYNPI 1
2 VYAITHPKFRAAVKKHIPCLSGCLPADEEETKTKTRGATTTASMSMTQTTAPTV 0
0 HDPQASVHSGSSVSVDDSSGVSRQDTMMVK 0
0 VEVDNRMEKAGGGAADTAPKDGTSVPTVSAQIEVRPSGNVNTKAEVIPSPQSAAVAHGASASPVPK 0
0 VAELSSSVSLESAAIPGKIPTPLPSQPIAAPIERHMAAMADDPPPKPRGVATTVNVRRSESGYERSQDSLRKK 0
0 AVSETRSRSFNSTKDHFASERQTSTTLNQPRDMYSGDMVKKTRQSPEKQEYDNPAFDAGIAEIDTDSENETEGSYDMLSVRFQAMAEEPPVETYRKASDMSINLGKASLMLTEAHDETVL* 0
>MEL_braBel Branchiostoma belcheri (amphioxus) Deut.Ceph.Bran AB205400 15936279 full Gq Amphiop6
0 MTEIPSFQPPINATEVEEENAVFPTALTEWFSE 0
0 VGNQVGEVALKLLSGEGDGMEVTPTPGCTGNGSVCNGTDSGGVVWDIPPLAHYIVGTAVFCIGCCGMFGNAVVVYSFIK 2
1 SKGLRTPANFFIINLALSDFLMNLTNMPIFAVNSAFQRWLLSDF 1
2 ACELYGFAGGLFGCLSINTLMAISMDRYLVITKPFLVMRIVTKQR 0
0 VMFAILLLWIWSLVWALPPLFGWSAYVSEGF 1
2 GTSCTFDYMTPKLSYHIFTYIIFFTMYFIPGGVMIYCYYNIFATVKSGDKQFGKAVKEMAHEDVKNK 0
0 AQQERQRKNEIKTAKIAFIVISLFMSAWTPYAVVSALGTLGYQDLVTPYLQSIPAMFAKSSAVYSPI 1
2 VYAITYPKFREAVKKHIPCLSGCLPASEEETKTKTRGQSSASASMSMTQTTAPV 0
0 HDPQASVDSGSSVSVDDSSGVSRQDTMMVK 0
0 VEVDKRMEKAGGGAADAAPQEGASVSTVSAQIEVRPSGKVTTKADVISTPQTAHGLSASPVPK 0
0 VAELGSSATLESAAIPGKIPTPLPSQPIAAPIERHMAAMADEPPPKPRGVATTVNVRRTESGYDRSQDSQRKK 0
0 VVGDTHRSRSFNTTKDHFASEQPAALIQPKELYSDDTTKKMARQSSEKHEYDNPAFDEGITEVDTDSENETEGSYDMLSVRFQAMAEEPPVETYRKASDLAINLGKASLMLSEAHDETVL* 0
>MEL6_braFlo Branchiostoma floridae (amphioxus) Deut.Ceph.Bran genomic 12435605 full Gq Amphiop6
0 MSPNLTNTSLLPNRTDRPELSPADVTMQLVFGSMMLVFGLIGVVGNAVALYAFCR 2
1 SRSLRRPKNYLIANLCLTDMVVCLVYSPIIVTRSLSHG 2
1 LPSKESCIVEGFVVGLGSIVSICSLAGIAVERYVTITQPIKSLSILTHRALLGAVSAVWVYAFLLAFPPLVGWGRYVSEESKISCTFDYLSTDDATRAHVIVLVIGAFGLPFSVITYCYV
RSFATVRKCTKERKQMSPLAKSDSRSEVKAAVNSFVITTSFCLCWCPYAVVATMGVSGFTVHSHAVFIAALLAKLSVLFNPVAYVLSIPSFRKALFSSSNDRTKYQTAFTFESLAKTSPV
ERKWCADSIERYRSSNVNIESTELTVPYSASRESCLLSRAATERLAGRSPSLTDIVREFGLQQTASHRETWV* 0
>MEL6_braBel Branchiostoma belcheri (amphioxus) Deut.Ceph.Bran AB050611 12435605 full Gq
0 MSSNLTNVSLVANRTDQTELSPTDVTMQLIFGSMMLVFGLIGVVGNVVALYAFCR 2
1 TRSLRRPKNYVVANLCLTDMFVCLVYCPIVVSRSFSHG 2
1 FPSKESCIVEGFMVGVGSIASICSLAAIAVERYLSVTQPLKSLTILTQRKLLVAVLTVWVYSLLLAFPPLVGWGRYVREETYISCTFDYLSTDDATRAYVITLVMGAFGFPLLTIAYCY
IRVFTTARKHAEERKFMSPLKRPESRTEIKTAVTACVITTSFCLCWCPYAVVATLGISGVSVQQQTVFSAALLAKLTVIINPIVYVLSIPNFRKALFAQEREKYASEDVVLTSLPGKTRRMK
KVERSQSSNSNVVIEVKESSMAYSTSRESCLLSRAATKRLAGKTKSIVDLVDEFGLQETAPHKESLV* 0
>MEL2_galGal Gallus gallus (chicken) Deut.Saur.Arch AY882944 17977531 full Gq syn(+GRID2+SMARCAD1 -PGDS -SEC24B +COL25A1)
0 MGTQPHSVTKSEIPDHVLYTVGTCVLVIGSIGIIGNLLVLYAFYS 2
1 NKKLRTPQNFFIMNLAVSDFLMSASQAPICFVNSLHREWILGDI 1
2 GCDLYAFCGALFGITSMMTLLAISVDRYLVITKPLRSIQWTSKKRTIQIIAAVWLYSLGWSVAPLLGW 1
2 SSYVPEGLMISCTWDYVTYSPANRSYTMILCCCVFFIPLIIILHCYLFMFLAIRSTGR 2
1 DVQKLGSCSRKSFLSQSMKNEWKLAKIAFVVIIVYVLSWSPYACVTLIAWAG 2
1 RGNTLTPYSKSVPAVIAKASAIYNPIIYAIIHPRYR 2
1 KTIHNAVPCLRFLIRISKNDLLRGSINESSFRTSLSSHQSLAGRTKNTCVSSVSTGEA 0
0 NWSDVELDTVEPAHEKLQPRRSHSFSSSLRQKRDLLPDSYSCSEETEEK 0
0 VSLSSSYLEKVLGRSAFPSSPVALVTSSLRAASLPVGLNSSSASRGAGSDISQMKTEESHNNGGLDSIVSNTVPQIIIIPTSETNLFQEEPEEEETELFHFHDKKNNLLDLEGLSSSTEFLEAVEKFLS* 0
>MEL2_anoCar Anolis carolinensis (lizard) Deut.Saur.Lepi genomic full Gq syn(+GRID2+ SMARCAD1 -ATOH1 +PDLIM5 +BMPR1B)
0 MGPHHRTKVDVPDHVLYTVGSCVLVIGCIGITGNLLVLYAFYS 2
1 NKRLRTPPNYFIMNLAVSDFLMSATQAPICFLNSMHKEWVLGDI 1
2 GCNLYAFCGALFGITSMITLLAISVDRYCVITKPLQSIKRTSKKRTCIIIVFVWLYSLGWSVCPLFGW 1
2 SSYIPEGLMISCTWDYVTYSPANRSYTMMLCCCVFFIPLVIIFHCYIFMFLAIRSTGR 2
1 RKSSISHSIKSEWKLAKIAFVAIVVFVLSWSPYACVTLISWAG 2
1 YARTLTPYSKSVPAVIAKASAIYNPIIYAIIHPRYR 2
1 RTIRSAVPCLRFLIPISKSDLSTSSMSESSFRASVSSRHSFSYRNKSTYISSISAKET 0
0 TWCDVELDPVESGHKKLQAYRSNSFSAKGVAEEESGLLLRTNNCNVPARKK 0
>MEL2_xenLae Xenopus laevis (frog) Deut.Amph.Anur genomic full Gq Xmop syn(SMARCAD1 +PDLIM5 +BMPR1B)
0 MDLGKTVEYGTHRQDAIAQIDVPDQVLYTIGSFILIIGSVGIIGNMLVLYAFYR 2
1 NKKLRTAPNYFIINLAISDFLMSATQAPVCFLSSLHREWILGDI 1
2 GCNVYAFCGALFGITSMMTLLAISINRYIVITKPLQSIQWSSKKRTSQIIVLVWMYSLMWSLAPLLGW 1
2 SSYVPEGLRISCTWDYVTSTMSNRSYTMMLCCCVFFIPLIVISHCYLFMFLAIRSTGR 2
1 NVQKLGSYGRQSFLSQSMKNEWKMAKIAFVIIIVFVLSWSPYACVTLIAWAG 2
1 HGKSLTPYSKTVPAVIAKASAIYNPIIYGIIHPKYR 2
1 ETIHKTVPCLRFLIREPKKDIFESSVRGSIYGRQSASRKKNSFISTVSTAET 0
0 VSSHIWDNTPNGHWDRKSLSQTMSNLCSPLLQDPNSSHTLEQTLTWPDDPSPKEILLPSSLKSVTYPIGLESIVKDEHTNNSCVR
NHRVDKSGGLDWIINATLPRIVIIPTSESNISETKEEHDNNSEEKSKRTEEEEDFFNFHVDTSLLNLEGLNSSTDLYEVVERFLS* 0
>MEL2_danRer Danio rerio (zebrafish) Deut.Acti.Otoc genomic full Gq syn(- +FLJ39155 +PDLIM5 -)
0 MEPQRQIYKRLDVPDHVHYIIAFLILIIGTLGVSGNALVMFAFYR 2
1 NKKLRSLPNYFIMNLAVSDFLMAITQSPIFFINCLYKEWMFGEL 1
2 GCKIYAFCGALFGITSMINLLAISIDRYLVITKPLQTIQWNSKRRTGLAILCIWLYSLAWSLAPLIGW 1
2 GSYIPEGLMTSCTWDYVSPSPANKSYTMMLCCFVFFIPLSIILYCYLFMFLSVRQASR 2
1 QKSSFVKQQSMRSEWKLAKIAAVVIVVYVLSWAPYACVTLVAWAG 2
1 HQDVLTPYSKTLPAVLAKSSAIYNPFIYAIIHNKYR 2
1 RTLAEKVPGLSCLSRSQKDGLSSSTNSDASAQDSSVSRQSSVSKNRLHSTMVQ* 0
>MEL2_tetNig Tetraodon nigroviridis (pufferfish) Deut.Acti.Perc genomic full Gq syn(- - - +BMPR1B)
0 MEPKDTHITSSFFSKVDVPDHVHYIIAFFVFVIGILGITGNVLVIFAFYS 2
1 NKKLRSLPNYFIVNLAVSDLLMASTQSPIFFINLYKEWMFGET 1
2 ACKMYAFCGALFGITSMINLLAISVDRYVVITKPLQTIRRSSKRRTALAILMVWLYSLAWSLAPLVGW 1
2 GSYIPEGLMTSCTWDYVTYTLANRSYTMMLCCFVFFIPLAIILCCYLLMFLAIRKTSR 2
1 RKSTLIQQKSIRSEWKLAKIAFVVIVVYVLSWSPYACVTLISWAG 2
1 YGSTLTPYSKSVPAVIAKASAIYNPIIYAIIHPRYR 2
1 KTIRSAVPCLRFLIPISKSDLSTSSMSDSSFRSALSCRHSYRSRSTYISSISAKET 0
>MEL2_takRub Takifugu rubripes (fugu) Deut.Acti.Perc genomic full Gq
0 MEPEDAHSPGSFINKVDVPDHVHYIVAFFVFVIGVLGMTGNVLVIFAFYS 2
1 NKKLRSLPNYFIVNLAVSDFLMASTQSPIFFINCLYKEWVFGEM 1
2 CKMYAFCGALFGITSMINLLAISIDRYVVITKPLQTIHWSSKRRTTLAILMVWLYSLAWSLAPLVGW 1
2 GSYIPEGLMTSCTWDYVTYTLANRSYTMMLCCFVFFIPLAIILSCYLLMFLAVRKTSR 2
1 RKSTLIQQKSIRSEWKLAKIAFVVIIVYVLSWSPYACVTLISWAG 2
1 HANILTPYSKAVPAIIAKASTIYNPFIYAIIHNKYR 2
1 MTLVEKFACLWFLSPTARKDCMSSSSISESSIRDSIISRQSTTSRSHFIAGSTRMVNVKSEMSLILNGP* 0
>MEL2_gasAcu Gasterosteus aculeatus (stickleback) Deut.Acti.Perc genomic full Gq syn(KNTC2 +FLJ39155 +PDLIM5 +BMPR1B)
0 MEPDNAHTQRSFINKVDVPDHAHYIVAVFVVVIGTLGITGNALVMLAVYS 2
1 NKKLRNLPNYFIMNLAVSDFLMAFTQSPIFFINCLYKEWAFGET 1
2 GCKIYAFCGALFGIASMINLLAISIDRYLVITKPLQAIHWGSKRRTTLAILLVWLYSLAWSLAPLVGW 1
2 GSYIPEGLMTSCTWDYVTYTLANRSYTMMLCCFVFFIPLGIILYCYLFMFLAIRKTSR 2
1 RKSTLIKQKSMKSEWKLAKIAFVVIVVYVLSWSPYACVTLISWAG 2
1 HADILSPYSKAVPAIIAKASAIYNPFIYAIIHNKYR 2
1 MTLAAKFPCLRFLSPTPRKDTSSSISESSYRDSVISRQSTASRTHFITACPDTVNFFFSFSSRLGCH* 0
>MEL2_oryLat Oryzias latipes (medaka) Deut.Acti.Perc genomic full Gq
0 MDPESTQGSLLSKVNVPDHAHYIVAMFVFVIGALGITGNALVMFAFYS 2
1 NKKLRNLPNYFIMNLAISDFLMAFTQSPIFFINCLYREWMFGET 1
2 GCKVYAFCGALFGISSMINLLAISVERYLVITKPLQTIHWSSKRKTTLAIFLVWFYSLAWSLAPLVGW 1
2 SSYIPEGLMTSCTWDYVTYTPANRSYTMMLCCFVFFIPLGIILYCYLRMFLSIRKTTr 2
1 RKSTVIQQKTIRSEWKLAKIAFVVIVVYVLSWSPYACVTLISWAG 2
1 HADILSPYSKAVPAVIAKASTIYNPIIYAIIHNKYR 2
1 MTLAEKVSCLRFLSPNPPKECTSYSFSESSFRDSIISRQSSVSRSHFINTLPSRADMVNDHKLVFI* 0
>MEL1_strPur Strongylocentrotus purpuratus (sea_urchin) Deut.Echi.Eleu XR_026330 frag G? opsin4 no cdna losing introns larval postoral arm ancestral intron
0 2
1 WTKSLRTPPNMLIVNLAISDFGMVITNFPLMFASTIYNRWLFGDA 1
2 GCQFYAFCGALFGIMSIANMTAIALDR 2
1 YYVICWSLEAVRSVTHRRSMIIIIIVWCYAIFWSIPPFFGVGSYVLEGYGLGCTFDFMTKDLNHYLHV
SFLFASSFVVPVTIIIVCFTRIAITVRAHRHELNKMRTKLTEDKDKKHKSSIRRANKAKTEFQIAKVGFQVTIFYVLSWM
PYSIVAVIGQYFDSDLLTPLGTVVPVIFAKCSAIWNPIIYCLSHEKFNAALKEKLMGMCGIEIPSKHRSMGSQESSVTGR
RGMHRQNSSTLSESSVTSTVDQDAIELKDRKQGPATVKVQQEKVEGGTYRRNPGDVTFSKDAGVEVDEKRRGDQGQRDDR
VRPQGEGQMDQWSQPPPAPASASAPTPGVNDKEYLTKM* 0
>MEL2_strPur Strongylocentrotus purpuratus (sea_urchin) Deut.Echi.Eleu DQ285097 full G? cdna: S droebachiensis retained intron: tube feet
0 MPTTLMENSTPGWMADDSQMEETHPAFPLIGGYLLVVVLLGTAGNSLVIYTFLRFKKLHSPINLLIVNLSASDLLVATTG
TPLSMVSSFYGRWLFGTNACAFYGFVNYYCGCISLNSLAAISVFRYIIVVRGQAQNNKLSLRSSIYAILVIHLYTLIFST
PPLYGWNRFVLAGYHTSCDIDFHTKTPLFVSYICYMFFFLFFLPLGLISWSYFKIYQRVSKHSNSMRTSFTGVTKEINSDEKHA 2
1 NHRRTASTLFVTIVVFLFAWFPYCIVSLWVLIGDANSISKLSTTIPSLFAKSSVIYNPLIYVVLNSKFRKALIQTLSFLKCLSKHELSESS* 0</font>
<font color ="brown">>MEL1_plaDum Platynereis dumerilii (ragworm) Ecdy.Anne.Poly AJ316544 11874910 full Gq rhabdomeric melanopsin unavailable genomically
0 MSRSEVLVPGSMSLDGLLTTAHPIGNDSI 0
0 ETILHPYWQQFDIENTIPDSWHYAVAAWMTFFGILGVSGNLLVVWTFLK 2
1 TKSLRTAPNMLLVNLAIGDMAFSAINGFPLLTISSINKRWVWGKL 1
2 WRELYAFVGGIFGLMSINTLAWIAIDRFYVITNPLGAAQTMTKKRAFIILTIIWANASLWALAPFFGW 1
2 GAYIPEGFQTSCTYDYLTQDMNNYTYVLGMYLFGFIFPVAIIFFCYLGIVRAIFAHHA 2
1 EMMATAKRMGANTGKADADKKSEIQIAKVAAMTIGTFMLSWTPYAVVGVFGMIK 2
1 PHSEMFIHPLLAEIPVMMAKASARYNPIIYALSHPKFR 2
1 AEIDKHFPWLLCCCKPKPKAQLPSSTTKGSIASKTEADTSV* 0
>MEL1_capCap Capitella capitata (polychaete) Ecdy.Anne.Poly genomic full G? jgi 119596 distally uncertain shares 2 introns with melanopsins
0 MMSYADGYLDNSTAPIEESPYLPHGTFFHPHWRPYREMLLNMNPLIYYGLGLYMAVVGIVGTLGNLVVITLFIK 2
1 TRSLRTPPNMFIINLALSDMGFCATNGFPLMTVASFQKLWRWGPV 1
2 ACELYALAGSITGFNSIATLALISMDRYMVIAKPFYAMKHVSHKRSLIQIILAWTWAFIWSAPPLLRMGYGRYIP
EGFQVSCTFDYLSRDLKNLIFVWCLFVFGFFIPVLAIACSYVGIIRAVGAQSKEMRKTAEKMGAKTGKSDKEKKQDIAMAKVA
AGTIGLFLMSWTPYAAVSMIGIAGNRSWITPYVSQIPVMFAKASAMWNPILYALSHPKFRAALEDHMPWLLVC* 0
>MEL1_helRob Helobdella robusta (leech) Ecdy.Anne.Clit genomic full G?
0 MDSVTWYKDFHPHWWKYHDIIVNAPMAFYYFLGTFFAVVGFLGVFGNIIVVWVFSR 2
1 TPSLRTPSNVLVINLAICDILFSALIGFPMSALSCFQRHWIWGNF 1
2 YCQFYSFVAGITGLASINCLAVIAVDRYLVVGQPLAMLNQSHFRRSFYHVLIIWTWACVWSAMPLIGWGEYILEGFGVSCTFD
YLTRTTWNISFNVCLFTFCFGMPVSVIILSYIGIIRSIAKNRKEFSSLTAENSSRARQEIKIAKVFAVCMTAFILCWVPYAT
VAQLGIYGYDQMVSPYTAELPVMLAKTSALWNPIIYAFSHPKYRKCLKELPIFRQKRKFRFLGSKSHTKSSDGVGTIALTSTINRTATRH* 0
>MEL2_helRob Helobdella robusta (leech) Ecdy.Anne.Clit genomic frag G? from scaffold_391
1 TPILRTHANVLIINLALCDLIFSSLIGFPMTALSCFKRHWIWGDL 1
2 GCDFYGFVAGWTGLGSITCLAFISIDRYMAIVHPFYMLNKKSSSVLTLLQIGAVWSWALIWSVMPLFGWGRFIPEAFGVSCTFDYLTRTWSNICFNYVLITCGFFLPVVIIVTSYIGIVIEVTKS 1
2 VEEDGMKDHMDAQNARCYVFVAVLSM 0
0 LKTAKVLACCFGAFLICWTPYAIVAQLGINGFAHLVTPFTSEVPVLFAKTSSIWNPLIYALSHPRYRRAV 0
>MEL1_schMed Schmidtea mediterranea (planaria) Loph.Plat.Turb AF112361 10220416 frag G?
0 eVYHYLVGVYISIVGISGVLGNLLVLYIFAR 2
1 AKSLRTPPNMFIMSLAIGDLTFSAVNGFPLLTISSFNTRWAWGKL 1
2 TCEIYGFIGGLFGFISINTMALISLDRYFVIAQPFQTMKSLTIKRAIIMLVFVWLYSLIWSTPPFFGY 1
2 GNYVPEGFQTSCTFDYLTQSKGNIIFNIGMYIGNFIIPVGIIIFCYYQIVKAVRVHELEMLKMAQKMNASHPTSMKTG 1
2 AKKADVQAAKISVIIVFLYMLSWTPYAIIALMALTGRRDHLNPYTAELPVLFAKTSAMYNPFIYAINHPKFRIQLEKKFPCLICCCPPKPK 0
0 * 0
>MEL1_schMan Schistosoma mansoni (trematode_worm) Loph.Plat.Trem AF155134 11166392 full G? 6 exons
0 MKQNLTFATLWPDDNDFASIVHSHWHKFIQPDPLYYYLVGIYIGIVGILAVMGNSLVITLFLL 2
1 CKQLRTPPNMLIVSLAISDFSFALINGFPLKTIAAFNHRWGWGKL 1
2 ACELYGFAGSIFGFISLTTMAFIALDRYLVIVQPFETFSRITYGKVIVMIFITWIWSALWSIPPFFGY 1
2 GSYIPEGFHTSCTFDYLSTDLPNLIFNAGLYILGFLCPVFIIIFSYYQIVKTVRLNELELMKMAQSLDLQNPSAMKTg 1
2 GDKKADIEAAKTSIILVLLYLMSWSPYAIVCLMTLIGSRDSLTPFHSELPVLFAKTSAVYNPIVYAVKHPKFRMEIEKRFPFLICCCPPKPK 0
0 ERLQNTIVSKIQVSQIGIGTVSGGNENTLNTVKRED* 0
>MEL2_schMan Schistosoma mansoni (trematode_worm) Loph.Plat.Trem CD096414 12973350 full G?
0 MSSNRTIEMLRPYMKDFDSIVLPYWYKFEQPNPYYQYAIGLFIAVVGITGMCLNLLVIVFFTM 2
1 FKSLRTPSNILVVNLAISDFGFSAVIGFPLKTMAAFNNFWPWGKL 1
2 ACDLYGLAGGLFGFVSLSTIAAVALDRYLVIATPFESVFQTTPRRTLLLMLFLWMWSLMWTIPPLFGF 1
2 GRYVTEGYQTSCTMDYISTDLNNRLFNIGLFGFGFLCPLFLSLFCYARIILIVRSRGKDFIEMAASSKGTNQKEKSANV 1
2 SSSKSDTFVSKSSAILLGVYLICWTPYSFVCLMALIGYADYITPLMVEIPCLCAKTANPCIYAFRYPKFRSLLQQRFGFLRLTKNRVSY 0
0 ERSQHAILSTIHVVTDCQYGTVSGGNENTLNTFILLD* 0
>MEL3_schMan Schistosoma mansoni (trematode_worm) Loph.Plat.Trem XM_002581128 full G?
0 MSEIKNFTRSLLLYNRTFSMIKNNIHDSDIIMLNHWIKYTQPDPIYNYLVAIFVALIGIFGTITNLLVIFVFL 2
1 TPKSSISLQCALIINLAISDFGFSAVIGFPLKTIAAFNQYWPWGSV 1
2 ACQLYGFISATFGFLSLTTIAAISFDRYLVIVKDHKTTNFRVICTVIGFLWIWSIIWTIPPFFGF 1
2 GRYVLEGYQTSCTFDYISNDMPSLLFSGGMYIFGFMFPVLLCIYCYVNLLKIVRNNERVVLISLSNDGASKQRESVR 1
2 NRKRLDIEATKSVILSLLFYLMSWTPYAMVCLISILGQSYFLTPTIAEMPHIFAKMAAIYNPILYAFTNRKFKNALGIRKTSSVIMQQQRLLSKGQLKPLVSLLFLVN* 0
>MEL1_lotGig Lottia gigantea (limpet) Loph.Moll.Gast FC774055 full G? ests long tail omitted 3 exons best: molluscan melanopsins
0 MTTLPPKENTTHLFDTWDDMFVHPHWKNFPPVSAAWHNFIGIFITFVGITGVIGNFVVIYTFSR 2
1 TKSLRTASNMFVVNLALSDLTFSAVNGFPLFSLSSFSHKWIFGRV 1
2 ACELYGLIGGIFGLMSINTMAMISIDRYLVITSPFTAMRNMTHKRAFLMIVGVWIWSILWAIPPIFGWGAYIPEGFQTSCTFDYLTRGDNRRSYIMCLYICGFVVPLGVIIFCYVFIIKSVMNHEKE
MAKMADKLDAKDVRSTKEKAKAEIKIAKVSMTIILLYLMSWTPYAIVALIAQWGPALVVTPYVSEIPVLFAKASAMHNPVIYALSHPKFRDAVSKLMPWFLCCCGLTDAEKKARDELAKSKFTRQT* 0
>MEL1_sepOff Sepia officinalis (octopus) Loph.Moll.Ceph AF000947 900420 full G? similar X56788 Loligo forbesi
0 MGRDIPDNETWWYNPTMEVHPHWKQFNQVPDAVYYSLGIFIGICGIIGCTGNGIVIYLFTK 2
1 TKSLQTPANMFIINLAFSDFTFSLVNGFPLMTISCFIKKWVFGMA 1
2 ACKVYGFIGGIFGLMSIMTMSMISIDRYNVIGRPMAASKKMSHRRAFLMIIFVWMWSTLWSIGPIFGWGAYVLEGVLCNCSFDYITRDSATRSNIVCMYIFAFCFPILIIFF
CYFNIVMAVSNHEKEMAAMAKRLNAKELRKAQAGASAEMKLAKISIVIVTQFLLSWSPYAVVALLAQFGPIEWVTPYAAQLPVMFAKASAIHNPLIYSVSHPKFREAIAENFPWII
TCCQFDEKEVEDDKDAETEIPATEQSGGESADAAQMKEMMAMMQKMQQQQAAYPPQGAYPPQGGYPPQGYPPPPAQGGYPPQGYPPPPQGYPPAQGYPPQGYPPPQGAPPQGAPPQ
AAPPQGVDNQAYQA* 0
>MEL1_todPac Todarodes pacificus (squid) Loph.Moll.Ceph X70498 11106382 full Gq squid rhodopsin 3D Cys 337 palmitoyled
0 MGRDLRDNETWWYNPSIVVHPHWREFDQVPDAVYYSLGIFIGICGIIGCGGNGIVIYLFTK 2
1 TKSLQTPANMFIINLAFSDFTFSLVNGFPLMTISCFLKKWIFGFA 1
2 ACKVYGFIGGIFGFMSIMTMAMISIDRYNVIGRPMAASKKMSHRRAFIMIIFVWLWSVLWAIGPIFGWGAYTLEGVLCNCSFDYISRDSTTRSNILCMFILGFFGPILIIFF
CYFNIVMSVSNHEKEMAAMAKRLNAKELRKAQAGANAEMRLAKISIVIVSQFLLSWSPYAVVALLAQFGPLEWVTPYAAQLPVMFAKASAIHNPMIYSVSHPKFREAISQTFPWVL
TCCQFDDKETEDDKDAETEIPAGESSDAAPSADAAQMKEMMAMMQKMQQQQAAYPPQGYAPPPQGYPPQGYPPQGYPPQGYPPQGYPPPPQGAPPQGAPPAAPPQGVDNQAYQA* 0
>MEL1_entDof Enteroctopus dofleini (octupus) Loph.Moll.Ceph X07797 full Gq
0 MVESTTLVNQTWWYNPTVDIHPHWAKFDPIPDAVYYSVGIFIGVVGIIGILGNGVVIYLFSK 2
1 TKSLQTPANMFIINLAMSDLSFSAINGFPLKTISAFMKKWIFGKV 1
2 ACQLYGLLGGIFGFMSINTMAMISIDRYNVIGRPMAASKKMSHRRAFLMIIFVWMWSIVWSVGPVFNWGAYVPEGILTSCSFDYLSTDPSTRSFILCMYFCGFMLPIIIIA
FCYFNIVMSVSNHEKEMAAMAKRLNAKELRKAQAGASAEMKLAKISMVIITQFMLSWSPYAIIALLAQFGPAEWVTPYAAELPVLFAKASAIHNPIVYSVSHPKFREAIQTTFPWL
LTCCQFDEKECEDANDAEEEVVASERGGESRDAAQMKEMMAMMQKMQAQQAAYQPPPPPQGYPPQGYPPQGAYPPPQGYPPQGYPPQGYPPQGYPPQGAPPQVEAPQGAPPQGVDNQAYQA* 0
>MEL1_aplCal Aplysia californica (sea_hare) Loph.Moll.Gast AASC01108363 full Gq 4 exons uncertainties
0 MNVSSSLTSQPYHELLHPHWLEHEEAPEGVHLSVGVFITLVGVLAVCGNSLVIITCIR 2
1 FKDLRTRSNILIINLAVGDLLMCLIDFPLLAAASFYGEWPYGRQ 1
2 VCQMYAFLTAIAGLVTINTLAVIAADRYWAVVRRPTPGQKLPKCVTSIAVASVWAYSISWALCPILGWGAYVLDGIRTTCTFDFLTRTWENRSFVIGMMIGNFVLPFALMVFSYFRIWVAVRKVKSG 2
1 NVFCAIRHNYNLALGSTLFVKQHRYRLHCEQKTVKIIMFLLIAFTVSWSPYLAVSIIGLFGDRSQLTYQNTLTASLIAKTSMVFNPILYSISHPKVRKRIANLACCYSVRRHQQQTSRIKTGRRSTSSATPSRS* 0
>MEL2_aplCal Aplysia californica (sea_hare) Loph.Moll.Gast AASC02005512 frag G? 1st exon missing; new 3rd intron
0 2
1 HSSLRTSSNLLVVNLTVADLVMSSLDFPILAISSYKGCWVMGFL 1
2 GCQVYGVSSGVAGLVTINTLAAISVDRFVVVVHRLSPMHQMGKSTT 1
2 GVIIIAIWALSVIWAVLPITGVSSYRLEGMGTSCTFDYASRTSSNRWFFIALVIFNFFIPLALIIFSYWRIYASVRAVKRELKLLQSARTSILRKRFEVQAEI
KTAITALVIISIFCLAWTPYVIIAFVGLYGPTTAIDPLVSMFPNILAKISTVSNPILYSIGHPEVRKKMKKLFLPGQQDSSWRATSATAGNSSPAQSENMNNISLPTYL* 0
>MEL2_lotGig Lottia gigantea (limpet) Loph.Moll.Gast genomic full G?
0 MSIASHVWTNSSTNHFNFSVLHQHWQNQTPLSTACQYTIGIFISTVAVIAVIGNSIVIWAHVR 2
1 IKSLSTTSNMLILNLCVGCLIMCIVDFPLYATSSFLQKWIFGHK 1
2 VCEIYATITGTAGLLIMNSYSAIAFDRFITVTRYNNPNYPRSKSATMCISGFVWIYSLSWSMAPVVGWSRYQLDGSGTT
CTFDYLSTTWTNRSFILSIAFFNFVLPLCFILFAYSRILHLISSHSREMKSYRSAVIISKGKASIPKRFRSERKTAITLLI
TVVVFCLSWVPYVIIALIGQFGNQSFITPQISVIPQLVAKLSTVTNPILYSLSHPVVRNKLFLRLRHELYRRPSDSVSSSRGIQMKNIEFI* 0
>MEL1_patYes Patinopecten yessoensis (scallop) Loph.Moll.Gast AB006454 9287291 full Gq retina
0 MADNKSTLPGLPDINGTLNRSMTPNTGWEGPYDMSVHLHWTQFP PVTEEWHYIIGVYITIVGLLGIMGNTTVVYIFSN 2
1 TKSLRSPSNLFVVNLAVSDLIFSAVNGFPLLTVSSFHQKWIFGSL 1
2 FCQLYGFVGGVFGLMSINTLTAISIDRYVVITKPLQASQTMTRRKVHLMIVIVWVLSILLSIPPFFGWGAYIPEGFQTSCTFDYLTKTARTRTYIVVLYLFGFLIPLIIIGVC
YVLIIRGVRRHDQKMLTITRSMKTEDARANNKRARSELRISKIAMTVTCLFIISWSPYAIIALIAQFGPAHWITPLVSELPMMLAKSSSMHNPVVYALSHPKFRKALYQRVPWLF
CCCKPKEKADFRTSVCSKRSVTRTESVNSDVSSVISNLSDSTTTLGLTSEGATRANRETSFRRSVSIIKGDEDPCTHPDTFLLAYKEVEVGNLFDMTDDQNRRDSNLHSLYIPTRVQHRPTTQSLGTTPGGVYIVDNGQRVNGLTFNS* 0</font>
<font color ="#996633">>MEL1_dapPul Daphnia pulex (water_flea) Ecdy.Crus.Bran genomic full G? no close homologs
0 MTSSNDSAGYLWAINATIWIIDDSNETLGIDWDDWDVSLWTQEQRQLLEHGGIPRQVHVALGVLLSFIVLFGFAANSTILYVFSR 2
1 FKRLRTPANVFIINLTICDFLACCLHPLAVYSAFRGRWSFGQT 1
2 GCNWYGMGVAFFGLNSIVTLSAIACERYIVITSSSCRPVVAKWRITRRQAQK 0
0 VCAGIWLHCAALVSPPLLFGWSSYLPEGVLVTCSWDYTSRTLSNRLYYFYLLFFGFFLPVSVLTFCYAAIFRFILRSSKEITRLIMTSDGTTSFSKSTVSFRKRRRQTDVRTALI
ILSLAILCFTAWTPYTIVSLIGQFGPVDEDGELKLSPMVTSIPAFLAKTAIVFDPLVYGFSSPQFRNSVRQILRQQSISSSGNAGNRAGPNNMAMARTAIQNSRASSHATVSSF
SRNARMFPKDPLSKKTPNDPFVSTPLAVQQIPHFRLPTDVDINEQQFRRGIYANKSVSYWIDIIVLLQLGENLRKSCMKRKNSFKIPAGSIPQKNKLSNSRCSLLEDVSTHSLA
LRQMIFRKEGELYLFHHQPSHNAELAANKMDHQGNNKRIRRRFSEADMMHRSGKCRKNLPVSTSFDQ* 0
>UV7_ixoSca Ixodes scapularis (tick) Ecdy.Chel.Arac genomic frag G? exon 1 missing exon 2 disjunct K90 at EIP XM_002408275 wrong
0 2
1 RRRIRSQANLLVFNLALSDLLMVLEIPLLVYNSLKLRPALGVW 1
2 GCQLYGLMGGLSGTSAIFSIAALSLERYLALGRPRDPFARLTRSRAFALSLSSWIYALCFSAWPLLGVTSPYVPEGFLTSCSFHFLSDATSDRCFVWIFFVAAWCVPLVFVTTCYSGILVTVIRSRKALAQES
RRSELRVAKVSLALVLLWTVAWTPYAIVALLGITGRRNLLTPWGSMAPAMFCKSAAVLDPFVYGLSHPSFRRELAIMLPCLRPRQRPVSLTLRAVVQLPKRPGPRSAGSSTSVPVTAPGTTKDNHCPTPPNVSR* 0
>UV7_tetUrt Tetranychus urticae (spider_mite) Ecdy.Chel.Arac GW013907 frag G? larval transcripts
AGCKIYGFFGGLSGTSAIMTIAMMAMERLNSISKPLSPHSRLSMRRALVISTLIWIYSLIFSTPPVFHLFNRYVPEGYLTSCSFDYLSKDLVSRIYIFAFFTAAWIVPLTLIVTSYVGIIIAVERNETMFQKTQDRLCERAS
SVYRASLRDSRGRSVKESGKMEMRLVKIVLSLIAFWILSWTPYAIIALLGLLDQSYITPTSSMIPAIFAKLSSVVNPYLYGLGNPRFKRELKRKLCFCVANKASVERRTVIQSTVTLGDPKEGTQFVHISDGNLSEIELSDYENR* 0
>UV7a_dapPul Daphnia pulex (water_flea) Ecdy.Crus.Bran frag ACJG01004266 tandem1
0 MLNHTHSISRETIHGNAICDQHRKFVNLYPVDVWKSSGFFDDIDLMDINCHWLQFEPPTPSSHFMLAIIYSVVFVIGFVSNTAIVYILLR 2
1 SKKLLTPANILLVNLAISDLLIISMIPIFLYNSFLQGPAIGGL 1
2 GCKVYGFLSGFSGTSTILTLAAIAIDRYLVISRPLDLAKKPTRTWAYATIAITWLYSATFASLPFLGAGKYVPEGYLTSCSFDYLSEDTGTRVFIFIFFVAAWVCPLT IITFCYAAITYVNICSTNTARPLIIIQHKYAGWRQCNIEIAIPKIVAGLVLSWIIAWTPYSLISLLGISGHTDLLTPLSSMLPALFAKTAACVDPFIYSLNHPKIRQEII
>UV7b_dapPul Daphnia pulex (water_flea) Ecdy.Crus.Bran genomic ACJG01004266 full tandem2
0 MNAINMCNQTNCATDVVTDDIIERWKLCGFFEDDDFLDINCHWLQFEPAPLVNHLLLVCIFVFILLTGCLCNIIVIYIFAR 2
1 SRHLRTPANIIIMNLAISDFFMLIKMPIFLYNSLLQGPALGIK 1
2 GCQIYGFMSGLTGTTSIMSLATVAVDRYLVISQPLNVNRKSTRTRAYLTTCFIWLYSAIFASLPLFGIGKYVPEGYLTSCSFDYLSNNVKTRSFILAFFLAAWLFPFCIITTCY
TAITYVNICSTNTARPLIIIQHKYAGWRQCNIEVVIAKIVVVLVAMWMISWTPYAFVALLGISGTQTRLTPGMTMFPALFAKFSACVNPIIYTLTHPKIKKEILRRWYCFMSSGTS
>UV7a_acyPis Acyrthosiphon pisum (aphid) Ecdy.Inse.Hemi SCAFFOLD4798 full G? 3 exons altered HEK K90
0 MIDFKTKYPVNLWKDHGLYTDDYIKLINSHWLKFMPPNPTSHYVLGLLYTVIMVFGCTGNSLVIFMYFK 2
1 CRSLQTPANMLIINLAVSDFIMLAKASVFIYNSYYLGPALGKL 1
2 GCQVCGFLGGLTGTVSIMTLAAISLDRYYVIVCPLKAAVKTTKQRARIWIGLIWIYGFSFSIVPVLDLGYSRYVSEGYLTSCSFDYLSDNDQDKRFI
LVFFTAAWCIPFTIILYCYVNILMAVWMTTEIVTSRVGQQEEKRKTDIRLGYMVIGALALWFVSWTPYAVVALLGVFDLKEYISPLSSMIPALFCKAAS
CTDPWFYAITHPRFKKELMKLLTKSKSRKLVRNYGMKKGWVGSHLNKNGSVDFDNCLKTEYKEENTTIFMLESDDNNLHCQGSTSGHKTESTKEPETKFTASASQETLKYMLPS* 0
>UV7b_acyPis Acyrthosiphon pisum (aphid) Ecdy.Inse.Hemi SCAFFOLD14504 full G? altered HEK CL3 K in in K90
0 MSDFKTKYPIDTWKEHGFYTDDYMKLINSHWFKFMPPNATSHYILGFLYSVIMVLGCFGNSLVIFMYIK 2
1 CKSLQTPANVLIMNLAVSDFIMLAKTPVFIYNSFYQGPTLGKL 1
2 GCQIYGFFGGLTGTVSIMTLAAISLDRYYVIVHPLNAAVKTTKQRARVWIGLIWIYGFLFSIIPVMDLGYNRYVPEGYLTSCSFDYLSDDNQEKGFILVFFTAAWCIPFTTISYCYIKI
LRAVWMTSEMAASRFGQEEEKRKTEIRLGYVVVGVIMLWFVSWTPYAMVALLGVFDRKDYITPLSSMIPAVLCKAASCMDPWIYAITHPRFKNELTKLMSRKKTRKLERDYGMKKNWGGQ
SYSNKSGAGLRNLSSSEDECVEEVIVVIDPDDKKMKRQGSTSSHKTEETKALETKFPPTRQESLKYMPPSWYKLPRTTSKSSIMLDPKLTGDDNNK* 0
>UV7_rhoPro Rhodnius prolixus (kissing_bug) Ecdy.Inse.Hemi genomic full G? K90 at KMP ortholog RH7 of droMel
0 mKYFHLYPIEQWKMHRFFTEEYLKLVNTHWFEYPPPNKQIHYIFAAVYFLVMLVGVSGNLLVIFMILR 2
1 FRTLRTSSNILILNLAVSDFLMVAKMPVFIYNSFYFGPVLGEM 1
2 GCHFYGFIGGLSGTASILTLAAIAMDRYLGIAHPLNFNQGRAKKRTIVWITFIWVYSITFASIPLSHIGVKTYVPEGFLTSCSFDYLSTDIQNRCFIFIYFVAAWCLPLLVIITSYVGICREVLRVSLIRKGQE
REQRKREAKLSAILALATFLWFLSWTPYAAVALLGIFGYKNHITQLASMIPALFCKTAACVNPFIYGLNHPRLRQQLLKLCCKKRYNLEKTHFSRSWRNTSCSFKLKEQSLCNVSQSRLRRTSTVASEPSEHSTHFM* 0
>UV7_pedHum Pediculus humanus (louse) Ecdy.Inse.Phth AAZO01007270 full G?
0 mKTFKLKWPEEWKKLGLFDDEYLYKINKYWMKFPPPSPMSHYFMGIIYSVIMVVGVFGNFLIIYLFLR 2
1 KRSLRTPSNVFIFNLAVSDSLLLLKMPVFIINSFYLGPALGNL 1
2 GCSAYGFVGGLTGTVSIMTLAAIAFDRYQVIVHPLERKTKAAVYFQILLIWIYAIFFSIIPLLDVGLNKYVPEGYLTSCSFDYLTQDTASRLTIFVFFVAAWIVPLSIILGSYM
ALYKVVLKARGTHFNTVMTRHCKDIEIQRPELKAAVTVICIVCLWTLSWTPYAVVALLGITGNEKYISPMSSMIPALFCKTASCIDPFVYAATNRRFRNELKRKYRKRSRYQPSLKTE
RKDFFTLSEDNNDRGKGNTIRIREK* 0
>UV7_spoLit Spodoptera littorali (butterfly) Ecdy.Inse.Lepi FQ016398 FQ021555 Cfrag male antenna
MFSTIGCWGNIIVLLMYLRCRTLRTPGNILVANLALSDFLMLAKTPIFIFNSFNLGPALGKTGCVIYGFVGGLTGTTSIATLSAIALDRYWAVVRPLEPL
RALTAIRARLLAIGAWLYACVFAIIPALDIGYGSYVPEGYLTSCSFDYLTEDFSPRCFIFVFFCAAWLAPFCTITFCYISIFRVVVFNTSMSYGNQDQRL
SSRHVKERTKRKAEIKLAFLVMAVIALFFISWTPYAIVALLGITGKKDVLTPITSMIPALFC
>UV7_mayDes Mayetiola destructor (hessian_fly) Ecdy.Inse.Dipt AEGA01002257 frag genomic
1 VYFLHSSYNGYPDTKVLESINIHWIGFNPPKPWEHYTLAIMISIIMTIGLIGNFLVICM 2
1 SRILKRASNILLLNLAFADFFMLAKSPIYIYNCLKFGPASGDL 1
2 ACRAYGFIGGLTGTVSIMTLSAISFDRYMGIMYPFNTEKFGNKKIRAFILVAFVWFYSFTFAIMPALNIGLSKYTPEGFLTSCGFDYLDNQTSARIFMFTFFIGAWMIPFLTITYCYIQIFRV
VNLTRQIQSNRKRQRAEQKLAIVVMNLIAIWFFAWTPYAIVALLGIAGQQQYITPWASMIPALFCKASACINPYIYSIRYPEFKQEIFRILSKYFKFADEHLQQNATRTMSVHFVTRTRVQINEQY* 0
>UV7_anoGam Anopheles gambiae (mosquito) Ecdy.Inse.Dipt XM_308329 full G? K90=EAP
0 MGRQGSGNAVRISPSSRNQPYFSSAHLSFVVPFPVHSKYVVRSGYVLPVDPLFVAKINPFWLRFDPPSAGEHYGLAVFYFLMMLFGVIGNALVVFMFYR 2
1 YRSLRTPANYLVINLAVADFIIMMEAPMFIYNSIHQGPALGSI 1
2 GCTVYALMGAVGGTVAIATLTVISIDRYNVVVYPLNPNRSTTKLKCYFLIAFTWAYGLLFASFPALEIGLSRYTAEGYLTACSFDYLDRTYKARVFMFVYFVFAW
LIPFAIISYCYARILIAVINANAIQSSKSKNKTEVKLAGVVVGIIGLWFAAWTPYAVVAMMGVFGYEQYLTPLNSMIPAVFAKIAASIDPYFYAMNHPRYRQMLER
MFCNRGADQGNSQYQTSHYTRGASRGGDSEGGGGEESGGGGGVGRAPGGGNAGLGRGGTVRGGGGGGRLIAGKGGGGANATGSTGGGGVKALKKQISNGDETSLEVSLEM* 0
>UV7_aedAeg Aedes aegypti (mosquito) Ecdy.Inse.Dipt XM_001650694 frag G? wrong exon 1 K90=EAP
0 FPPNSRYMALSGYSGPTIEDAFRDRINPFWLQFDPPSRTAHYILGFIYFMMMMFGLCGNLLVILMFFR 2
1 FKSLRTPANYLVINLAIADFIIMLEAPLFVYNSYHQGPATGNVWCTIYALLGAVGGTVAIVTLTMISIDRYNVVVYPLNPKRSTTRLKVALMIVF
AWIYGLVFSVIPALDIGLSRYTPEGFLTACSFDYLERTRDARLFMFLYFIFAWVVPIIAITFCYIQILRVVIGANSIQSSKNKSKTEVKLAGVVIGIIGLWFIAWTPYAIVAMMGV
FGYESLLSPLGSMVPAILAKTAACIDPYFYAMNHPRYRQELRKMFGLNQQDLGNSQYQTSRYTRNASRMDDSEGGASERVTIGRQPGKTTTDEPEPSQQTEQGPQPTYSKNLAANS
RGALQRAQSSISAADDTSLSVSIDLTETNPNSNH* 0
>UV7_culQui Culex quinquefasciatus (mosquito) Ecdy.Inse.Dipt XM_001861603 frag G? wrong exon 1 K90=EAP
0 PEPVHPASKYISLSGYDGPPVEDAFRDRINPFWLQFEPPSPVAHYALGFVYFLMMVWGLFGNVLVIFMFFK 2
1 FKSLRTPANYLVINLAVADFLIMLEAPIFVYNSYHLGPAFGNTL 1
2 CTIYSLLGAIGGTVAIMTLTMISVDRYNVVVYPLNPNRSTTRLKVMLMIVFTWIYALVFSL
MPALEIGLSRYTPEGFLTACSFDYLDRGWDARVFMFMYFVFAWVIPFLTISYCYVAILRVVVGAGSIQSSKNKNKQEVKLAGVVIGIIGLWFIAWTPYAVVAMLGVFGYEHLLTPL
GSMIPAILAKTASCIDPYFYAMNHPRFRQELRKMFGKEQEMNHSQYQTSRYTRNASRNDSEAGPSERVQLGRAPGKDADPIPAVSSSVAQPNYSQNLASNRKGGLQRAQSSISAAD
DTSLSCSIDLTETQPNNH* 0
>UV7_bomMor Bombyx mori (moth) Ecdy.Inse.Lepi BGIBMGA012539 full G? kaikoblast
0 MSEILDRRSNVSGEVKETRLPIKYSKYEVNELVSSEANNEVLIKKFKELWPVNLWRRFGLFTDDYLHLVNPYWLSFAPPHPLLHYGLGAFYIMMTTVGSTGNALVMFMYFR 2
1 CRSLRTPGNILVANLALSDFMMLAKTPIFIFNSFNLGPALGKT 1
2 GCVIYGFVGGLTGTTSIAILTAISLDRYWAVVRPLEPLRALTAIRARLMAIAAWIYATLFAIIPALDIGYGRYVPEGFLTSCSFDYLTEELPPRYFIFVFFCAAWLAPFCTISYC
YISIFRVVVCSRNITTKNQEQRLSTRHVKERTKRKAEIKLAFLVIVVIALFFISWTPYAIVALLGIFGKKDLIKPLTSMIPALFCKTAACINPFIYIITHPKFRKEFKRMLSRDKTE
RSGTIKTIGYYTEASKFHRPSKDFSDTEVEIVEMKDIPYRNEDTTNTVEEKINTVSAKLAKREGSQKSQSSISMKSFEENVVSPPSWYCKPKFAKKKSFHRRSTHSMVSQNTDPTV* 0
>UV7_droMel Drosophila melanogaster (fruitfly) Ecdy.Inse.Dipt NM_079311 full G? RH7 long N-terminal has M comp genomics support 2 of 3 exons novel
0 MEAIIMTTLPNLTTDAGDSSFWLTGALSLSEMLANSSHSHSTGSTTSTAGSSATESSAVNVGKDHDKHVNDSVSTGLS 2
1 NYSNYPSYIHYRDKYDLSYIAKVNPFWLQFEPPKSSTFLIMAALYCLISVVGCVGNAFVIFMFANRKSLRTPANILVMNLAICDFLMLIKCPIAIYNNIKEGPALGDI 1
2 ACRLYGFVGGLSGTCAIGTLTAIALDRYNVVVHPLQPLRRCSRLRSYLIILLIWCYSFLFAVMPALDIGLSVYVPEGFLTTCSFDYLNKEMPARIFMALFFVAAYCIPLTSIVYSYFYILKVVFTASRIQSNKDKAKTEQ
KLAFIVAAIIGLWFLAWSPYAIVAMMGVFGLERHITPLGSMIPALFCKTAACVDPYLYAATHPRFRVEVRMLFYGRGVLRRVSTTRSSYMTRSRSSFTHRLRTSTTGEGGMGDHRMENYLMNNNLMMVPEETEENEEIVVVAEINNSISSVMEQSKF* 0
>UV7_droYak Drosophila yakuba (fruitfly) Ecdy.Inse.Dipt genomic 12209654 full G? RH7 chr3L:12207286 12209654
0 MEAIIMTTLPALTTDAGDSSSFWLTGALSLSEMLANSSHGHSTGSTSSTAGSSATESSTVNVGKDHDVTKHVNDSVSTGLS 2
1 NYSNYPSYIHYRDKYDLSYIAKVNPFWLQFEPPKSSTFLVMAALYFLISVVGCVGNAFVIFMFANRKSLRTPANILVMNLAICDFLMLIKCPIAIYNNIKEGPALGDI 1
2 ACRLYGFVGGLSGTCAIGTLTAIALDRYNVVVHPLQPLRRCSRLRSYLIILLIWCYSFLFAVMPALDIGLSVYVPEGFLTTCSFDYLNKETPARIFMALFFVAAYCIPLTSIVYSYFYILKVVFTASRIQSNKDKAKTEQ
KLAFIVAAIIGLWFLAWSPYAIVAMMGVFGLERHITPLGSMIPALFCKTAACVDPYLYAATHPRFRVEVRMLFYGRGVLRRVSTTRSSYMTRSRSSFTHRLRTSTTGDGGMGDHRMENYLMNNNLMMVPEETEENEEIVVVAEINNSVSSVMEQSKF* 0
>UV7_droAna Drosophila ananassae (fruitfly) Ecdy.Inse.Dipt genomic full G? RH7 scaffold_13337 frameshifted
0 MEAIILSTLPSLTTNASGSSSHWLTGALSLPEILANSSGSPNTSSADTGSGINLSARDADRHFNISTEAR 2
1 NYSYYPGYIHYRDKYDLSYIAKVNPFWLQFEPPHSSTFLAMAALYCLISVVGCVGNAFVIFMFANRKSLRTPANILVMNLAICDFLMLVKCPIAIYNNIKEGPALGDV 1
2 ACRIYGFVGGLSGTCAIGTLTAIALDRYNVVVHPLQPLRRCSRLRSYLIILLIWCYSFLFAVMPALDIGLSVYVPEGFLTTCSFDYLNKETPARIFMALFFVAAYCFPLTAIVYSYFYILKVVFSAGRIQSNKDKAKTEQ
KLAFIVAAIIGLWFLAWSPYAVVAMMGVFGLEKHITPLGSMIPALFCKTAACVDPYLYAATHPRFRVEVRMLFYGRGILRRVSTTRSSYMTRSRSSFTHPAGRADGGTGRDHRMETYLMNNNLMMVPEETEENEEIVVVAEINNSVSSAIEQSKF* 0
>UV7_droPse Drosophila pseudoobscura (fruitfly) Ecdy.Inse.Dipt genomic full G? RH7 chrXR_group6:2491547 2493151
0 MEALMAALPTLTTEAAGSSLWLTSALSLSEMLANSSTSPNASLVAATTSSAAVATASTTSAAEAVGKVPDKHEVNDNVSTVLS 2
1 TSSSYPGYIHYRDKYDLSYIARVNPFWLQFEPPKSSTFYLMAALYCLISVVGCVGNAFVIFMFANRKSLRTPANILVMNLAICDFLMLVKCPIAIYNNIKEGPALGDA 1
2 ACRIYGFVGGLSGTCAIGTLTAIALDRYNVVVHPLQPLRRCSRLRSYLIIFLIWSYSFLFAVMPALDIGLSVYVPEGFLTTCSFDYLNKETPARIFMALFFVAAYCVPLTTIVYSYFYILKVVFTASRIQSNKDKAKTEQ
KLAFIVAAIIGLWFLAWSPYAIVAMMGVFGQERHITPLGSMIPALFCKTAACVDPYLYAATHPRFRVEVRMLFFGRGVLRRVSTTRSSYMTRSRSSFNRRLRPTPDAEHRVESYLMNNNLMMVPEETEENEEIVVVAEFNNSSYSGMEQSKF* 0
>UV7_droWil Drosophila willistoni (fruitfly) Ecdy.Inse.Dipt genomic full G? RH7 scaffold_180949
0 MDMDMALDMNDAATTTSLWITSAALSLSEILVNTTSHVVTTSPASTSTVETTAVAAVTATGKVVHDDEKHHHHHHHHHQDEVNDNNVTTVLR 2
1 NFSSYPGYIHYRDKYDLSYIAKVNPFWLQFEPPRSSTFYIMAALYCLISVVGCIGNAFVIFMFSNRKSLRTPANILVMNLAICDFLMLVKCPIAIYNNIKEGPALGDI 1
2 ACRIYGFVGGLSGTCAIGTLTAIALDRYNVVVHPLQPLRRCSRLRSYLVIVMIWCYSFLFAIMPALDVGLSVYVPEGYLTTCSFDYLNKETPARIFMALFFVAAYCVPLTCIMFSYFYILKVVFTANRIQSNKDKAKTEQ
KLTFIVAAIIGLWFLAWSPYAVVAMMGVFGLEQHITPLGSMIPALFCKTAACVDPYLYAATHPRFRVEVRMLIYGRGVLRRVSTTRSSYITRSRSSFTRRLRTGSELDMRTEPYIMNNNLMMVPEETEENEEIVVVAEINNPSRCVSMHEHTSKF* 0
>UV7_droMoj Drosophila mojavensis (fruitfly) Ecdy.Inse.Dipt genomic full G? RH7 scaffold_6680
0 METIMSTLPTLTADDGSLWITSALTELLASGANSSSGSSSVVADGTQNATFVAAATTTTTTVAAAAAAAAAAAVNASTATTANATKGHHKHPHGVNDSETDLR 2
1 LCSSYPGYIHYRDKYDLTYIAKVNPFWLQFEPPDTSTFYIMAALYCLISVVGCVGNAFVIFMFGSRKSLRTPANILVMNLAICDFLMLVKCPIAIYNNIQEGPALGDA 1
2 ACRLYGFVGGLSGTCAIGTLTAIALDRYNVVVHPLQPLRRYSRLRSYLIIFAIWCYSFLFAVMPALDVGLSVYVPEGFLTTCSFDYLNKETPARIFMALFFVAAYCIPLASIVYSYFYILKVVFTANRIQSSKDKAKTEQ
KLTFIVAAIIGLWFIAWSPYAIVAMMGVFGQEQHITPLGSMIPALFCKTAACVDPYLYAATHPRFRVEVRMLMYGRGVLRRVSTTRSSYMTRSRSSFTHRLRPSSGDCENRAEPYTLNNNLMMVPEETEENEEIIVVAEINNSISGVMEQSKF* 0
>UV5_plePay Plexippus paykulli (jumping_spider) Ecdy.Chel.Arac AB251851 18217181 full G? PpRh3 kumopsin3
MLNNTIPGPATLDDIGPPSWCYETRFNGWNAAPDIYVPDYWKQFRAPAPYLHYMLGFFYICLMSIAVV
GNAIVMYIFFSAKTLRTPTNMFVIGLAMADLLMMSKTPVFIYNCFHLGPVFGQIGCDIYGIVGTYSGIGSAFCNAIIAYDRYRVIVHP
FSKSGMSITKAIAFLVIIYLYITPFAILPALKIWSRYVPEGFLTSCSADFFMQDFNGRSYIV
GTWFFGWFIPVAAIVFFYVQIFLAVKDHEEKIKEQARKMNVDSIRSNEAVKNSSAEVRIAKTAMCVFLMFLSSWAPYILVAFITGFSDPKLKRITPVISMVPAMTIKASACFDPFF
YALSHPRYRLELQNRMPWLCINEKAEASGPADDSVSKTTEHVA*
>UV5_hasAda Hasarius adansoni (jumping_spider) Ecdy.Chel.Arac AB251848 18217181 full G? HaRh3 kumopsin3
MLNNTALQPAVLDDIGPPSWCYETRFNGWNAAPDILVPDYWKQFRAPAPYLHYILGCLYICLMSVALI
GNAIVIYIFSVSKSLRTPTNMFVIGLAMADLLMMSKTPVFIYNCFHLGPVFGQLGCDIYAIVGTYSGIGSAFCNAVIAYDRYRVIVHP
FSKSGMTMTKAIAILVIVYLYITPFAILPALKIWSRFVPEGFLTSCSSDFYMQDFNGRSYIV
GTWFFGWFIPVAAIIFFYAQIFLAVKDHEEKIKEQARKMNVDSFRSNEALKNSSAEVRIAKTAMCVVLLFLTSWVPYILVAFIAGFSDPKLKRVTPVISMIPAMTIKGSACFDPFF
YALSHPRYRLELQNKLPWLCINEKAEASGPADDSVSKTTEHVA*
>UV5_braKug Branchinella kugenumaensis (fairy_shrimp) Ecdy.Crus.Bran AB293436 18984904 full G?
MANVTGFDYYRYERRELGWNTPAEYMEFVHPHWKQFEAPNPFLHYMLGVFYIIFMFCSLIGNGVVIWVFASAKSLRTPSNLFVINLAVLDFLMMLKTPVFIVNSFNEGPIWGKTGCDFFALLGSYAGIGGATTNAAIAFD
RYRTIAHPFDGKLSRGQAITLCMLCWLYATPFSLMPFFGIWGRFVPEGFLTTCSFDYITEDSSTRAFVGTIFFTSYVLPMILIIYFYSQIVGHVRQHEETLRAQAKKMNVATLRSGKDDQEQSAEVRIAKVCIGLFSMFV
ISWTPYAAVALLCAFGNRAAVTPLVSMIPALTCKAVACIDPWIYAINHPRYRLELQKRLPWFCIHEPEPNNDSASVNSEKTVATTTPS*
>UV5_triLon Triops longicaudatus (tadpole_shrimp) Ecdy.Crus.Bran AB293435 18984904 full G?
MAFLQNQTYDGTSPSFSFFRTSERIMLGHNTPKDYMEYVHPHWQTFEAPNPFLHYLLGVLYIGFMFCALVGNGVVIWIFSSAKSLRTPSNMFVINLAVLDFIMMMKTPVFIVNSFNEGPIWGKFGCDLFALMGSYSGIGG
AMTNAAIAFDRYRTIARPFDGKLSRGKVLTICAGIWLWATPFSLMPLFGIWGRFVPEGFLTTCSFDYMTETSSIRWFVGCIFTYSYIIPLGLIIYYYSKIVGHVQEHERILREQARKMNVESLRSGKDQQEKSAEIRIAK
VAIGLSLMFVVAWTPYALVALIAAFGNRAVLTPLVSMIPACCCKAVACIDPWIYAINHPRYRLELQKRMPWFCVHEPEPEMIDNSSAITEKTST*
>UV5_triGra Triops granarius (tadpole_shrimp) Ecdy.Crus.Bran AB293430 18984904 full G?
MAFLQNQTHDGTSPSFSFYRTSERVMLGQYTPKDYMDYVHPHWQTFEAPNPFLHYLLGVLYIGFMFCALVGNGVVIWIFSSAKSLRTPSNMFVINLAVLDFIMMMKTPVFIVNSFNEGPIWGKFGCDMFALMGSYSGIGG
AMTNAAIAFDRYRTIARPFDGKLSRGKVLTICAGIWLWATPFSLMPLFGIWGRFVPEGFLTTCSFDYMTETSSIRWFVGCVFTYSYIIPLGLIVYYYSKIVGHVQEHERILREQARKMNVESLRSGRDHQEKSAEIRIAK
VAIGLSLMFVVAWTPYALVALIAAFGNRAVLTPLVSMIPACCCKAVACIDPWIYAINHPRYRLELQKRMPWFCVHEPEPEIIDNSSAITEKTST*
>UV5a_dapPul Daphnia pulex (water_flea) Ecdy.Crus.Bran FE384049 full G?
0 MLGWNTPEDYMSYVHP 2
1 YWKTFEAPNPFLLYMIGFLYTIFMFCCVAGNGVVIWIFTN 2
1 CKSLRTPSNMLVVNLAILDMLMMLKSPVMIINSYNEGPIWGKLGCDVFGLMGSYNGIGSAVNNAAIAYDRHR 2
1 TISRPLDGKLSRKQVTLMIVAIWAWATPFSVMPFLGIWGRYVP 1
2 EGFLTTCTFDYMTEDASTRFFVGSIFVYSYVIPLAMLIFYYSKIVRSVGDHEKTLRDQAKKMNVTSLRSNRDQNEKSAEVRIAKVAIALATLFVFAWTPYAFVALTAAFGNR 2
1 SVLTPLLSTVPACCCKLVSCINPWIYAINHPRYR 2
1 MELQKKMPWFCIHEPVPTNDDSSVGSATTEMSGVSKETSS* 0
>UV5b_dapPul Daphnia pulex (water_flea) Ecdy.Crus.Bran genomic full G? penultimate intron lost last intron has slid back 2 aa
0 MNGWNTPADYKSYVHPHWLSYEEPNPMLHHLLGVLYIFFMIASCLGNGIVIYIFST 2
1 TKELKTPSNILILNLAICDFIMMIKTPIFIVNSFNEGPVFGRLGCSIFGLLGAYVGPCSAVTNAAIAYDRYR 2
1 CISDPMGKRWSKSQASLIVLGCWVYASPVSLLPFTEIVNRFVP 1
2 EGYLTSCTFDYMTDNLETKMFVFILWIWCWIMPLGVIIFSYGKITTQVMTHEARLKEQAKKMNVESLRSGANKDARNEIRVAKVGISLTTLFLLSWTPYFAIAFIGCYGNR SLLTPGLSMIPACTCKMAACVDPFVYAINHPK 2
1 YRLELMKRFPWLCVHEKDDSTRSENSTNATIASEAESRT* 0
>UV5_triCas Tribolium castaneum (flour_beetle) Ecdy.Inse.Cole genomic full G?
0 MYVVHPFKIIRNKVTILRTMETMANHLGWNVPKDELIHIPQHWLVYPEPEASMHFLLALIYIGFFIMATIGNGLVIWIFST 2
1 SKSLRTASNMFVVNLAICDFAMMIKTPIFIYNSFYRGFALGHLGCQIFAFIGSLSGIGAGMTNACIAYDRYT TITRPFDGKITRTKALVMIIFVWGYTIPWAVMPLLEIWGRFAP 1
2 EGFLTACSFDYLTDTFDNHMFVTSIFICSYVIPMSMIIYFYSQIVSKVFSHEKALREQ 0
0 AKKMNVESLRSNQSQQASQSAELRIAKAAIAICSLFVASWTPYAVLALIGAFGDQSLLTPGVTMVPACACKFVACLDPYVYAISHPKYR 2
1 LELQKRLPWLAIKETAASETQSTTTENTTTQSATTTT* 0
>UV5_lucCru Luciola cruciata (firefly) Ecdy.Inse.Cole AB300329 19232386 full G?
MILHNATVFAAAQTQDDPDSIVHLLGWNVPKSELHHIPEHWLVYPEPEASIHYLLGIVYIFICFMGIVGNGLVLWIFSTSKSLKTASNMFVVNLAFCDFIMM
MKMPIFVYNSFNRGYALGHIGCQIFGFVGSLSGIGAGMTNAFIAYDRYATISNPLEGKLTRTKALIMIFIIWGYTFPWAVLPMFEVWCRFVPEGFLTSCTFDYLTDTFDNDMFVAV
IFICSYVIPMSMIIYFYSQIVKHVMHHEKALRDQAKKMNVESLRSNQSLQSQSIEIKIAKVAIMVCFLFVASWTPYAVLALIGGFGDQSLLTPGVTMVPALACKFVACLDPYVYAL
SHPRYRMELQKRLPWLAIKEDAVSDAQSMVTTTTAAATPAATEQAPTA*
>UV5_anoGam Anopheles gambiae (mosquito) Ecdy.Inse.Dipt XM_556823 full G? novel short exon
0 MGLVQLDNQTAYRPEALIGADQSGLRYLGWNVPPEELVHIPEHWLQFPEPEASLHYLLGLLYIAFTIFSLVGNGLVIWIFIA 2
1 AKSLRTPSNVFVINLAICDFFMMAKTPIFIYNSFTKGFTLGNLGCQIFGFVGSLT 1
2 GIGAGATNALIAYDR 2
1 YNTITRPFEGRLTQTKAIIFICLIWAYTIPWGVLPLLEIWGRYVP 1
2 EGFLTSCTFDYLSGTFDTRLFVASIFTFSYVLPMSLIIYYYSQIVSHVVNHEKSLREQAKKMNVESLRSNQNQKDASVEIRIAKAAITVC
FLFVASWTPYAVLALIGAFGDKSLLTPGVTMFPACACKFVACLDPYVYAISHPRYRIELQKRLPWLAITETLPAENASTCTEQQDGNATTQS* 0
>UVB_anoGam Anopheles gambiae (mosquito) Ecdy.Inse.Dipt XM_312478 full G?
0 MFLGNESISEGAMLMPMARTAGEMPKLLGWNLPPEEQYLVHDHWKGFPSPPYYMHLMLAMIYFVLMNTSLIGNGIVLWIFGT 2
1 SKSLRNGSNMFIINLAIFDLLMMCEMPMFLVNSFSERLVGYGVGCSVYAALGSMSGIGGAISNAVIAFDRYRTISNPLDGRLSRVQAGLLICLTWLWTMPFTLLPLFEIWGRY
IPEGYLTTCSFDYLTDDPDTRVFVGCIFTWAYVIPMIFICYFYARLFGHVRQHEMMLKNQARKMNVESLTANRSEKAQAVEMRIAKAAFTIFFLFVCAWTPYAIVTMIGAFGDR 2
1 TMLTPFVTMVPAVCCKIVSCLDPWVYAISHPKYRQELERRLPWMGIKEADDSVSTTES* 0
>UV5B_droMel Drosophila melanogaster (fruitfly) Ecdy.Inse.Dipt NM_057748 19398933 full G? RH5 two small introns also seen in Apis and Daphnia
0 MHINGPSGPQAYVNDSLGDGSVFPMGHGYPAEYQHMVHAHWRGFREAPIYYHAGFYIAFIVLMLSSIFGNGLVIWIFST 2
1 SKSLRTPSNLLILNLAIFDLFMCTNMPHYLINATVGYIVGGDLGCDIYALNGGISGMGASITNAFIAFDRYKTISNPIDGRLSYGQIVLLILFTWLWATPFSVLPLFQIWGRYQP 1
2 EGFLTTCSFDYLTNTDENRLFVRTIFVWSYVIPMTMILVSYYKLFTHVRVHEKMLAEQAKKMNVKSLSANANADNMSVELRIAKAALIIYMLFILAWTPYSVVALI
GCFGEQQLITPFVSMLPCLACKSVSCLDPWVYATSHPKYRLELERRLPWLGIREKHATSGTSGGQESVASVSGDTLALSVQN* 0
>UV4_droMel Drosophila melanogaster (fruitfly) Ecdy.Inse.Dipt NM_057353 19949290 full G? RH4 one ancestral intron with intercolated genes
0 MEPLCNASEPPLRPEARSSGNGDLQFLGWNVPPDQIQYIPEHWLTQLEPPASMHYMLGVFYIFLFCASTVGNGMVIWIFST
SKSLRTPSNMFVLNLAVFDLIMCLKAPIFIYNSFHRGFALGNTWCQIFASIGSYSGIGAGMTNAAIGYDRYNVITKPMNRNMTFTKAVIMNIIIWLYCTPWVVLPLTQFWDRFVP 1
2 EGYLTSCSFDYLSDNFDTRLFVGTIFFFSFVCPTLMILYYYSQIVGHVFSHEKALREQAKKMNVESLRSNVDKSKETAEIRIAKAAITICFLFFVSWTPYGVMSLI
GAFGDKSLLTPGATMIPACTCKLVACIDPFVYAISHPRYRLELQKRCPWLGVNEKSGEISSAQSTTTQEQQQTTAA* 0
>UV3_droMel Drosophila melanogaster (fruitfly) Ecdy.Inse.Dipt NM_079687 9165115 full G? RH3 single exon
0 MESGNVSSSLFGNVSTALRPEARLSAETRLLGWNVPPEELRHIPEHWLTYPEPPESMNYLLGTLYIFFTLMSMLGNGLVIWVFSAAKSLRTPSNILVINLAFCDFMMMVKTPIFIYNSFH
QGYALGHLGCQIFGIIGSYTGIAAGATNAFIAYDRFNVITRPMEGKMTHGKAIAMIIFIYMYATPWVVACYTETWGRFVPEGYLTSCTFDYLTDNFDTRLFVACIFFFSFVCPTTMITYY
YSQIVGHVFSHEKALRDQAKKMNVESLRSNVDKNKETAEIRIAKAAITICFLFFCSWTPYGVMSLIGAFGDKTLLTPGATMIPACACKMVACIDPFVYAISHPRYRMELQKRCPWLALNEKAPESSAVASTSTTQEPQQTTAA* 0
>UV5_acyPis Acyrthosiphon pisum (aphid) Ecdy.Inse.Hemi SCAFFOLD14509 full G? 8 exons K90
0 MDFNRTVSRPLAQLGs 2
1 SLMENEVGETHLLGWNLQAEDLIHIPEHWLKYQEPSSLQHYYLAFMYTIFMFVALFGNGLVIWVFCV 2
1 AKPLRTPSNIFVINLALCDFVMMAKAPIFILGSINRGYQ GHFLCQLFGTAGAFSGIGASATNAAIAYDRFS 2
1 TIAKPFDGRMTYGRAFFLIICIWTYTLPWGLLPLTEKWNRYVP 1
2 EGYLTSCTFDYLSPTDETRAFVGIMFVICYVIPVSLVIFFYSQIVSHVFNHEKALREQ 0
0 AKKMNVESLRSNQDANAQSAEVRIAKAAITICCLFIASWTPYAVVAMIGAFGDR 2
1 SLLTPGITMIPAIFCKTVACFDPYVYAISHPRYR 2
1 LELSKRVPCLGISEKPPPTASETQSTTTAA* 0
>UV5_rhoPro Rhodnius prolixus (kissing_bug) Ecdy.Inse.Hemi genomic frag G? exon 1 missing K90 at KTP
0 0
1 ASTSGNIRTLGWNLSPEDLKHIPEHWLSYPEPEPILNYALGVLYIFFMLIALIGNGLVIWIFST 2
1 AKTLRTPSNIFVVNLAICDFLMMSKTPIFIYNSFKLGYALGHRACQIFALLGSFSGIGASATNAVIAYDRYR 2
1 VIATPFAPKLSRTKAVLYLALVWAYVTPWALLPLFEQWSRFVP 1
2 EGFLTSCTFDYLTPTSEIRNFVTVMFFICYVFPMSLIIYFYSQIVSHVIIHEHNLREQ 0
0 AKKMNVESLRSNANMHTQSAEIRIAKAAITICFLFVASWTPYAVLALIGAYGNQ 2
1 DLLTPAVTMIPACACKAVACVDPYVYAISHPRYR 2
1 QELSKKFPWLDIKEAPAPSSVDANSTATEMTLPTQTSPAEA* 0
>UV5_apiMel Apis mellifera (bee) Ecdy.Inse.Hyme AF004169 9502802 full G? 5 exons
0 MSNDSIHWEARYLPAGPPRLLGWNVPAEELIHIPEHWLVYPEPNPSLHYLLALLYILFTFLALLGNGLVIWIFCA 2
1 AKSLRTPSNMFVVNLAICDFFMMIKTPIFIYNSFNTGFALGNLGCQIFAVIGSLTGIGAAITNAAIAYDRYS 2
1 TIARPLDGKLSRGQVILFIVLIWTYTIPWALMPVMGVWGRFVPEGFLTSCSFDYLTDTNEIRIFVATIFTFSYCIPMILIIYYYSQIVSHVVNHEKALREQAKKMNVDSLRSNANTSSQSAEIRIAK 0
0 AAITICFLYVLSWTPYGVMSMIGAFGNKALLTPGVTMIPACTCKAVACLDPYVYAISHPKYR 2
1 LELQKRLPWLELQEKPISDSTSTTTETVNTPPASS* 0
>UV5_attCep Atta cephalotes (ant) Ecdy.Inse.Hyme wgs ADTU01002850 full 83% bee
0 MVNESIHWEARVLSAEPIRLLGWNVPAEELIHIPEHWLIYPEPNPSLHYLLAIVYIIFTFVALLGNGLVIWIFCS 2
1 AKSLRTSSNLFVVNLAFCDFFMMIKAPIFIYNSFNTGFATGHLGCQIFAFIGSLSGIGAGMTNAAIAYDRYS 2
1 VIARPLDGKLSRGQVILFIVLIWAYTIPWALMPIMHVWGRFVPEGFLTSCTFDYLTDTPEIQYFVATIFTFSYCIPMSLIIYYYSQIVNHVIDHEKALREQAKKMNVESLRSNVSANTQTMEIRIAK 0
0 AAITVCFLFVLSWTPYGVLAMIGAFGDKTLLTPGITMIPACTCKFVACLDPYVYAISHPRYR 2
1 LELQKRLPWLELQEKSTDTQSSTSEVVNVPSS* 0
>UV5_nasVit Nasonia vitripennis (jewel_wasp) Ecdy.Inse.Hyme XM_001608024 full G? gene wrong transcripts GE436449 GE390962
0 MPYYNWNGTDQTAGWPEARIQPAGAPRLLGWNVPPEELVHIPEHWLVYPEPNPALHYLLALLYILFTFVALLGNGLVIWIFCA 2
1 AKSLRTPSNMFVVNLAICDFMMMLKTPIFIYNSFHTGFALGNLGCQIFSFIGSLSGIGASITNAAIAYDRYS 2
1 TIARPLDGKLSRGQVMMLIVLIWMYTIPWALMPSMGVWGRFVP EGFLTSCTFDYITDSDEIRYFVGTIFTFSYAIPMTLIIYFYSQIVGHVVNHEKALREQAKKMNVESLRSGQNKDQASAEVRIAK 0
0 VALTICFLFVAAWTPYGVMSLIGAFGNK SLLTPGVTMIPACCCKAVACLDPYVYAISHPRYR 2
1 LELQKRMPWLELQEKPPASDATSTTTEAVPASS* 0
>UV5_papXut Papilio xuthus (butterfly) Ecdy.Inse.Lepi AB028218 full G? Rh5
0 MIPAAVMDNHTENNYNYGAYFAPYRLEGVELLGAGLTGEDLAAIPEHWLSYPAPPASAHTMLALVYVFFTAAALIGNGLVIFIFSASKSLRTPSNLLVVQLAVLDFLMMLKAPIFIYNSIK
RGFASGVIGCQIFAFMGSVSGTAAGLTNACIAYDRHSTITRPLDGRLSRGKVLLMMVCVWLYTAPWAILPQLQIWGRYVPEGFLTSCTFDYLTTTFD
NKLFVASMFVCVYIFPMIAILYFYSGIVKQVFAHEAALREQAKKMNVDSLRSNQNAAAESAEIRIAKAALTVCFLYVASWTPYGVMSLIGAFGDQNLLTPGVTMIPALACKGVACI
DPWVYAISHPKYRQELQKRMPWLQIDEPDDNASNTTSNTANSSAPA* 0
>UV5_bomMor Bombyx mori (moth) Ecdy.Inse.Lepi BABH01012019 -------- frag G? ---
0 1
2 VEMLGDGLSGDDLAAVPEHWLTFPAPPASAHTALALLYIFFTAAALLGNGLVIFVFST 2
1 TKSLRTSSNLLILQLAILDFIMMAKAPIFIYNSAMRGFATGTIGCQIFSVMGAYSGIGAGMTNACIAYDR 2
1 HSTITRPLDGRLSKGKVLLMMAFVWIYCTPWALLPLLKIWGRYVP 1
2 EGYLTSCTFDYLTNTFDTKLFVACIFVCSYVFPMSMIIYFYSGIVKQVFAHEAALR 2
1 EQAKKMNVESLRANQSGASQSAEIRIAKAALTVCFLFVASWTPYGVMALIGAFGDQQLLTPG 0
0 VTMIPAVACKAVACIDPWVYAISHPKYR 2
1 QELQRRMPWLQINEPDDTTSTATSNTVSSAPPAAPA* 0
>UV5_manSex Manduca sexta (moth) Ecdy.Inse.Lepi L78081 9343857 full G? Manop2
0 MNNQSENYYHGAQFEALKSAGAIEMLGDGLTGDDLAAIPEHWLSYPAPPASAHTALALLYIFFTFAALVGNGMVIFIFSTTKSLRTSSNFLVLNLAILDFIM
MAKAPIFIYNSAMRGFAVGTVGCQIFALMGAYSGIGAGMTNACIAYDRHSTITRPLDGRLSEGKVLLMVAFVWIYSTPWALLPLLKIWGRYVPEGYLTSCSFDYLTNTFDTKLFVA
CIFTCSYVFPMSLIIYFYSGIVKQVFAHEAALREQAKKMNVESLRANQGGSSESAEIRIAKAALTVCFLFVASWTPYGVMALIGAFGNQQLLTPGVTMIPAVACKAVACISPWVYA
IRHPMYRQELQRRMPWLQIDEPDDTVSTATSNTTNSAPPAATA* 0
>UV5_pedHum Pediculus humanus (louse) Ecdy.Inse.Phth AAZO01000117 full G? exon 1 uncertain
0 MKITTESENNISLSYYQPF 1
2 IDKEESLIWNVDPSELVHIPDHWFNFSAPHPLSNYLLGFLYFIFFVISCTGNGIVIWIFTT 2
1 SKNLRTASNVFVVNLAIFDFIMMAKTPIMIYNSMNLGFECGFVWCQIFASAGALSGIGASITNTCIAYDRCE 2
1 TITNPLQ KSGKKKAFLLAAFTWIYALPWAVLPFLEIWGKFAPEGYLTTCTVDYLTDTSQTRMFIVTIFFAAYVLPLSLIIYFYTKIVLHVINHEKSLKAQ 0
0 AKKMNVESLRSDGNKNYAVEIRITKVAIAMCFLFVISWTPYAVVALIGCFGNK 2
1 HLITPLVSMIPACACKAVACIDPYIYAISHPRFR 2
1 VEVNKRFACLAGCLQEKELQDDAVSKNTVNAENVDT* 0
>UV5_diaNig Dianemobius nigrofasciatus (cricket) Ecdy.Inse.Orth AB458852 full G?
MELQGSNVSNLSVWRPEARLATRLLGWNVPAEELIHIPEHWLTYPAPDAFSYYILGMLYVAFCFIALIGNGLVIWVFSSAKTLRTPSNIFVINLALYDFIMM
LKTPIFIYNSFNLGFGLGQLGCQIFAFMGSVSGIGAAATNACIAYDRYRVIARPFDSKMSIKGATLLVLLVWMWALPWAILPLLEIWGRYAPEGYLTSCSFDYLTDTPENHMFVLC
IFICSYVIPMSLIIYFYSQIVSHVVNHEKALKEQAKKMNVDSLRSNQQQNQTSAEIRIAKVAIGICFLFVASWTPYAVLALIGAFGNKALLTPGVTMIPACTCKAVACLDPYVYAI
SHPRYRAELQKRLPWLCIKEESASDTTSNATTTSTNAGATST* 0
>UVB_acyPis Acyrthosiphon pisum (aphid) Ecdy.Inse.Hemi SCAFFOLD14509 full G? 8 exons K90
0 MDFNRSVSRPLSQLGS 2
1 SFMENEEELQLMGWNLTPEDLTHIPEHWLSYPEVRSLYHYILAFSYTILFCLGVIGNGLVLWIFCV 2
1 SKPLRTPSNLFVLNLALCDFSMVLVLPILIYDSIDHKYP GHLQCQIFALCGSISGIGAGATNAAIAYDRYS 2
1 TIAKPFEGRMTYGKALILIICIWIYVLPWCLLPLTEKWNRFVP 1
2 EGFLTSCSFDYLTPTEETKAFVGTMFVICYVIPMSFIIYFYSQIVCHVFNHEKALREQ 0
2 AKKMNVESLRSNQDANAQSAEVRIAKAAITICFLFVAAWTPYAVVAMIGAFGDQ 2
1 SLLTPIASMLPAVFAKTVACFDPYVYAISHPKYR 2
1 LELSKRVPCLGITEKPLATSDTQSITTAA* 0
>UVB_megVic Megoura viciae (vetch_aphid) Ecdy.Inse.Hemi AF189715 10762427 full G?
MDFNRSVSRPLSQLGSSFMENEDELQLMGWNLTPEDLTHIPEHWLSYPEVRSLYHYILAFSYTILFCIGVI
GNGLVLWIFCVSKPLRTPSNLFVLNLALCDFSMVLVLPILIYDSIDHKYPGHLQCQIFALCGSISGIGAGATNAAIAYDRYSTIAKP
FEGRMTYGKALILIICIWIYVLPWCLLPLTEKWNRFVPEGFLTSCSFDYLTPTEETKAFVGTMFVICYVIPMSFIIYFYSQIVCHVFNHEKALREQAKKMNVESLRSNQDANAQ
SAEVRIAKAAITICFLFVAAWTPYAVVAMIGAFGDQSLLTPIASMLPAVFAKTVACFDPYVYAISHPKYRLELSKRVPCLGITEKPPAASDTQSITTAA* 0
>UVB_apiMel Apis mellifera (bee) Ecdy.Inse.Hyme AF004168 9502802 full G? 8 exons
0 MLLHNKTLAGKALAFIAEEG 2
1 YVPSMREKFLGWNVPPEYSDLVHPHWRAFPAPGKHFHIGLAIIYSMLLIMSLVGNCCVIWIFST 2
1 SKSLRTPSNMFIVSLAIFDIIMAFEMPMLVISSFMERMIGWEIGCDVYSVFGSISGMGQAMTNAAIAFDRYR 2
1 TISCPIDGRLNSKQAAVIIAFTWFWVTPFTVLPLLKVWGRYTT 1
2 EGFLTTCSFDFLTDDEDTKVFVTCIFIWAYVIPLIFIILFYSRLLSSIRNHEKMLREQ 0
0 AKKMNVKSLVSNQDKERSAEVRIAKVAFTIFFLFLLAWTPYATVALIGVYGNR 2
1 ELLTPVSTMLPAVFAKTVSCIDPWIYAINHPR 2
1 YRQELQKRCKWMGIHEPETTSDATSAQTEKIKTDE* 0
>UVB_attCep Atta cephalotes (ant) Ecdy.Inse.Hyme wgs ADTU01025579 ADTU01025580 frag 74% bee
0 2
1 DVQPLQEEHFLGWNFPPEHADLVHPHWRVFLAPGRLWHVALALIYFLLLMLSLLGNGIVIWIFST 2
1 SKSLRTPSNIFILNLAVFDLLMATEMPMLIINSFLERTIGWETGCDVYALLGAISGMGQAITNAAIAFDRYR 2
1 TISCPIDGRLNGKQAMVLALFTWFWALPFSILPMTGLWGRYVA 1
2 EGFLTTCSFDYLTDDEDTRTFVITIFFWAYVLPMLLIIYFYSQLLKSIRSHEKMLRDQ 0
0 AKKMNVKSLVSNQNKERSVEMRIAKVAFTIFFLFVLAWTPYAVVALIGAYGNR 2
1 EALTPFSTMLPAIFAKTVSCIDPWIYAINHPR 2
1 YRQELEKRCKWMGIREKVAEDTVSAQTEKVNAEET* 0
>UVB_nasVit Nasonia vitripennis (jewel_wasp) Ecdy.Inse.Hyme XM_001604572 full G?
0 MAFVGLNGAMGGMGPA 1
2 EKPLQRYSQGPQMQEHLLGWNHPPEHIDIVHPHWRGFLAPGKYWHIGLALIYFMLLVLSFVGNGCVVWIFST 2
1 SKVLRTPSNLFIINLALFDLVMALEIPMLIINSFIERMIGWGLGCDIYAALGSVSGIGSAITNAAIAYDRYR 2
1 TISCPIDGRLNGKQAAVMVAFTWFWTMPFTILPFAKIWGRYTT 1
2 EGFLTTCSFDFLSDDQDTKVFVAAIFSWSYCFPMVLIIYFYSQLIKSVRRHEKMLREQ 0
0 AKKMNVKSLSAQDKERSVEMRIAKVAFTIFFLFVCSWTPYAVVTMIAAFGNR 2
1 ELVTPFSSMLPAVFAKTVSCIDPWVYAINHPR 2
1 YRQELTKRCQWMGIHEPDSGPSQNNAEAVSVTTEKLKSDDA* 0
>UVB_bomMor Bombyx mori (moth) Ecdy.Inse.Lepi BABH01016294 -------- full G? ---
0 MALNFTQEISDIGPMAYPLKM 2
1 VSREMVEHMLGWNIPEEHQDLVHEHWRNFPSVSKYWHYCLALIYAMLMVTSLVGNGIVIWIFGT 2
1 SKSLRSASNMFVINLAIFDLMMMLEMPLLIINSFYQRLVGYQLGCDIYAVLGSLSGIGGAITNAVIAFDRYK 2
1 TISCPLDGRINKVQASLLIAFTWFWALPFTILPAFRIWGRYVP 1
2 EGFLTTCSFDYFTDDQDTKVFVACIFVWSYCIPMTLICYFYSQLFGA 0
0 VRLHERMLQEQ AKKMNVKSLAANKEDASRSVEIRIAKVAFTIFFLFVCAWTPYAFVTMTGAFGDR 2
1 NLLTPIATMVPAVCCKVVSCIDPWVYAINHPR 2
1 YRAELTKRLPWLGVRESDPDAVSTTTSVGTAQSQATAEA* 0
>UVB_manSex Manduca sexta (moth) Ecdy.Inse.Lepi AD001674 9343857 full G? exons from 454
0 MATNFTQELYEIGPMAYPLKM 2
1 ISKDVAEHMLGWNIPEEHQDLVHDHWRNFPAVSKYWHYVLALIYTMLMVTSLTGNGIVIWIFST 2
1 SKSLRSASNMFVINLAVFDLMMMLEMPLLIMNSFYQRLVGYQLGCDVYAVLGSLSGIGGAITNAVIAFDRYK 2
1 TISSPLDGRINTVQAGLLIAFTWFWALPFTILPAFRIWGRFVP 1
2 EGFLTTCSFDYFTEDQDTEVFVACIFVWSYCIPMALICYFYSQLFGA 1
0 VRLHERMLQEQAKKMNVKSLASNKEDNSRSVEIRIAKVAFTIFFLFICAWTPYAFVTMTGAFGDR
1 TLLTPIATMIPAVCCKVVSCIDPWVYAINHPR 2
1 RAELQKRLPWMGVREQDPDAVSTTTSVATAGFQPPAAEA* 0
>UVB_diaNig Dianemobius nigrofasciatus (cricket) Ecdy.Inse.Orth AB291232 full G?
MNSSVGLQGAPIALPYESYVAQMLGWNIPAEHIELVHSHWRGYEAPSKYWHYWFAFMYFCIMIMSCLGNGIVLWIFATTKSLRTPSNMFVVNQALLDLLMMI
EMPMFVLNSLFYQRPIGWEMGCDIYALLGAVSGIGSAINNAAIAYDRYRTISFPLDGRLQFGHALAFIVGVWSWAMPFSLLPLLKVWGRYVPEGLLTTCSFDYLTDDEDTKVFTAS
IFTWSYAFPLCLIVFFYCKLFKQVRLHEKMLQEQARKMNVKSLQTNQDVAQKSVEIRIAKVAFTIFFLFLCSWTPYATVAMIGAFGNRALLTPMSTMIPALFSKIVSCIDPWIYAI
NHPRFRGELLKRAPWFGVEELKSSDVSSIGTDRTTATAAIETPAA* 0
>LMS_ixoSca Ixodes scapularis (tick) Ecdy.Chel.Arac EW898719 full G? ocellar transcripts
0 MGSEGQRTNMSLLDELASPYMKNGTLVESVPDEMLYMVHPHWYNFKPMNPLWHSLLGFAMVILGVISVVGNSMVIYIMTTSKSLRSPTNMLVVNLAFSDW 2
1 CMMAFMMPTMAANCFAETWILGPFMCEVYGMVGSLFGCGSIWSMVMITLDRYNVIVRGVAAAPLTHKRAALMIFFVWFWALTWTLLPFFGWSR 2
1 YVPEGNMTSCTIDYLTKALWSASYVVAYAGGVYWTPLFINIYCYSKIVRAVAQHEKQLRLQARKMNVASLRANAEQTKTSAEARLAK 0
0 IALMTVGLWFMAWTPYLTIAWAGIFSDGSKLTPLATIWGSVFAKANACYNPIVYGISHPKYRAALARRFPSLVCMPPGGDQLDTRSEASGITTIEDKVMTTET* 0
>LMS_tetUrt Tetranychus urticae (spider_mite) Ecdy.Chel.Arac GW028305 frag G? larval transcripts
CEFYGMWGSLFGCGSVWSLVFITRDRYNVIVRGMSAGRLTIKKSLAQVLFIWFYSVAWTIIPFFGWSRYVPEGNMTSCTIDYLSKDLWNASYTVVYAVAVYFLPLFTLVYHYYYIVCAVATHERTLREQA
KKMNVASLRANADANKESADIRIAKVAMMTVGLWFMAWTPYCTLAFLGIFTDGDYLTPMVSIWGAVFAKSAACYNPIVYALSHPKYRSALFTRFPSLACGVGAVEPVVDDDAKSEMSVATTFSDHTSAP* 0
>LMS1_plePay Plexippus paykulli (jumping_spider) Ecdy.Chel.Arac AB251849 18217181 full G? PpRh1 kumopsin1
MLPQAAKMAARASSGVDGKNISIVDLLPEDMLYMIHEHWYKYPPMESTMHYLLGITIILIGIISVS
GNSIVIYLMLSVKSLRTPANFLVTSLAVSDGGMLAFMAPTMPINCFAQTWVLGPFMCELYGMVGSLFGSASIWNMVMITLDRYNVIVRG
MSGKPLTKVGALLRIIFVWVWSLGWTIAPMYGWSSYAPEGSMTGCTVDYLHTDISTMSYLIVY
AIFVYFVPLFIIIYCYTYIVMQVAAHEKSLREQAKKMNIKSLRSNEDNKKASAEFRLAKVALMTICLWFMAWTPYLILSLLGIFSDREWLTPLTSIWGAVFAKAASAYNPIVYGIS
HPKYRAALHEKFPCLNCATESPKGDSASTVAESDKGGD*
>LMS2_plePay Plexippus paykulli (jumping_spider) Ecdy.Chel.Arac AB251850 18217181 full G? PpRh2 kumopsin2
MSSQIINGAYMVSRDALGLHLPTNLGGPLPQDNSYYPYLRNTTVVDTVPKEILHMIHDHWYQFPPLNPLWHSLLGIAMILLGIVSVI
GNGMVMYLMNTTKSLKTPTNMLIVNLAFSDFCMMAFMMPTMAANCFAETWILGPFMCEIYGMAGSLFGCVSIWSMVMIAFDRYNVIVRG
MNAEPLTTKKAAAQIFLIWAWAIMWTVLPFFGWSRYVPEGNM
TSCTVDYLSEDLKSSSYVLIYGCAVYFIPLFTLIYNYTFIVRAVSIHEDNLREQAKKMNVTSLRANADQQKQSAECRLAKIALMTVGLWFIAWTPYLCIAWSGIFSSRKHLTPLAT
IWGAVFAKAVAVYNPIVYGISHPKYRAALFQKFPSLACTTESDVIDNKSEVTFVTDEKPPKTQEA*
>LMS1_hasAda Hasarius adansoni (jumping_spider) Ecdy.Chel.Arac AB251846 18217181 full G? HaRh1 kumopsin1
MLPHAAKMAARVAGDHDGRNISIVDLLPEDMLPMIHEHWYKFPPMETSMHYILGMLIIVIGIISVS
GNGVVMYLMMTVKNLRTPGNFLVLNLALSDFGMLFFMMPTMSINCFAETWVIGPFMCELYGMIGSLFGSASIWSLVMITLDRYNVIVKG
MAGKPLTKVGALLRMLFVWIWSLGWTIAPMYGWSRYVPEGSMTSCTIDYIDTAINPMSYLIAY
AIFVYFVPLFIIIYCYAFIVMQVAAHEKSLREQAKKMNIKSLRSNEDNKKASAEFRLAKVAFMTICCWFMAWTPYLTLSFL
GIFSDRTWLTPMTSVWGAIFAKASACYNPIVYGISHPKYRAALHDKFPCLKCGSDSPKGDSASTVAESEKAGE*
>LMS2_hasAda Hasarius adansoni (jumping_spider) Ecdy.Chel.Arac AB251847 18217181 full G? HaRh2 kumopsin2
MSSHTINSAFMVPRDVLGLHLPNNLGGPLPHDNSYYPYLRNATVVDTVPKEILHMIHDHWYQFAPLNPLWHSLLGIAMIILGIVSVI
GNGMVIYLMSTTKSLKTPTNMLIVNLAFSDFCMMAFMMPTMAANCFAETWILGPLMCEIYGMAGSLFGCVSIWSMVMIAFDRYNVIVRG
MSAEPLTTKKAAAQIFFIWTWATTWTLFPFFGWSRYVPEGNMTSCTVDYLTEDLKSSSYVLIYGCAVYFTPLFTLIYNYTFIVRSVSIHENNLREQAKKM
NVSSLRANADQQKQSAECRLAKIALMTVGLWFIAWTPYLSIAWSGIFSSRKHLTPLATIWGAVFAKAVAVYNPIVYGISHPKYRAALFEKFPSLACTTESDVTDNKSEVTLVTDEKPPKTQEA*
>LMS_limPol Limulus polyphemus (horseshoe_crab) Ecdy.Chel.Mero AY190512S1 14977331 full G? intronated lateral_eye
0 MANQLSYSSLGWPYQPNASVVDTMPKEMLYMIHEHWYAFPPMNPLWYSILGVAMIILGIICVLGNGMVIYLMMTTKSLRTPTNLLVVNLAFSDFCMMAFMMPTMTSNCFAETW
ILGPFMCEVYGMAGSLFGCASIWSMVMITLDRYNVIVRGMAAAPLTHKKATLLLLFVWIWSGGWTILPFFGWSR 2
1 YVPEGNLTSCTVDYLTKDWSSASYVVIYGLA 0
0 VYFLPLITMIYCYFFIVHAVAEHEKQLREQAKKMNVASLRANADQQKQSAECRLAK 0
0 VAMMTVGLWFMAWTPYLIISWAGVFSSGTRLTPLATIWGSVFAKANSCYNPIVYGISHPRYKAALYQRFPSLACGSGESGSDVKSEASATTTMEEKPKIPEA* 0
>LMS_neoOer Neogonodactylus oerstedii (mantis_shrimp) Ecdy.Crus.Mala DQ646869 17053049 full G? Rh1
MSYWNSNKIVEEYSLPSTNPYGNFTVVDTVPENMLHMIHSHWYQFPPLNPMWYGILAFVVTVVGLCSICGNFVVIWVFMNTKALRSPANTLVVSLAVSDFIM
MACMFPPLVLNCYWGTWIFGPLFCEVYAFIGNTVGCASIGNMIFITFDRYNVIVKGISGTPLSQKNTTLQVLFVWICSIMWCVFPFFGWNRYVPRGDMTACGTDYLTEDEFSRSYL
YVYSVWVYIGPLALIIYCYFHIVSAVATHEKQMRDQAKKMGVKSLRTEEAKKTSAECRLAKVALTTVSLWFMAWTPYLIINWAGMFYPSVVSPLFSIWGSVFAKANAVYNPIVYAI
SHPKYRAALYKKLPCLACSTESADEGSATNSATTTTAEKYESA* 0
>LMS_lucCru Luciola cruciata (firefly) Ecdy.Inse.Cole AB300328 19232386 full G?
MSVLGEPSFAAWASQAGVMSSRFGGGNITVVDKVPPDMLHLIDAHWYQYPPLNPLWHAILGFMIGVLGCISVTGNGMVIYIFSTTKSLRSPSNLLVVNLAFS
DFLMMFTMAPPMVINCYNETWVWGPLFCQIYGMLGSLFGCTSIWTMTMIALDRYNVIVKGLSAKPLTKQGALIRIFLVWVFSIGWTIAPVFGWNRYVPEGNMTACGTDYLSTGWFS
RSYILFYSWFVYFIPLFAIIYSYWFIVQAVSAHEKAMREQAKKMNVASLRSSEAAQTSAECKLAKVALMTISLWFLAWTPYLVTNYAGIFDGSKISPLATIWSSLFAKANAVYNPI
VYGISHPKYRQALQKKFPSLVCAAEPDDTVSQTTAATAASEEKAAA* 0
>LMS_triCas Tribolium castaneum (flour_beetle) Ecdy.Inse.Cole ES544655 18342244 full G? 3 exons from AAJJ01000967 5 fusion relative to bee
0 MSVMGEPNFIAWAAQRSGYGGGNLTVVDKVLPDMLHLVDAHWYQFPPMNPLWHGILGFVIGVLGFVSIVGNGMVIYIFSSTKALRTPSNLL
VVNLAFSDFLMMlCMSPAMVINCYNETWVLGPLVCELYGMSGSLFGCASIWTMTFIALDRYNVIVKGLSAQPLTKKGAMLRILIIWVFSTLW
TIAPFFGWNRYVPEGNMTACGTDYLTKDWVSRSYILVYAVWVYFVPLFTIIYSYWFIVQ 0
0 AVAAHEKSMREQAKKMNVASLRSSEAAQTSAECKLAKIALMTITLWFFAWTPYLVTNFTGIFEGAKISPLATIWCSLFAKANAVYNPIVYGIS 2
1 HPKYRQALQKKFPSLVCAGEPDDTTSTASGVTNVTTDEKPATA* 0
>LMS1_droMel Drosophila melanogaster (fruitfly) Ecdy.Inse.Dipt NM_079683 19398933 full G? RH1 ninaE
0 ME 0
0 SFAVAAAQLGPHFAPLSNGSVVDKVTPDMAHLISPYWNQFPAMDPIWAKILTAYMIMIGMISWCGNGVVIYIFATTKSLRTPANLLVINLAISDFGIMITNTPMM
GINLYFETWVLGPMMCDIYAGLGSAFGCSSIWSMCMISLDRYQVIVKGMAGRPMTIPLALGKIAYIWFMSSIWCLAPAFGWSR 2
1 YVPEGNLTSCGIDYLERDWNPRSYLIFYSIFVYYIPLFLICYSYWFIIA 0
0 AVSAHEKAMREQAKKMNVKSLRSSEDAEKSAEGKLAKVALVTITLWFMAWTPYLVINCMGLFKFEGLTPLNTIWGACFAKSAACYNPIVYGIS 2
1 HPKYRLALKEKCPCCVFGKVDDGKSSDAQSQATASEAESKA* 0
>LMS6_droMel Drosophila melanogaster (fruitfly) Ecdy.Inse.Dipt NM_079644 19398933 full G? RH6 gross genomic misassembly exon1
0 MASLHPPSFAYMRDGRNLSLAESVPAEIMHMVDPYWYQWPPLEPMWFGIIGFVIAILGTMSLAGNFIVMYIFTSSKGLRTPSNMFVVNLAFSDFMMMFTMFPPVVLNGFYGT
WIMGPFLCELYGMFGSLFGCVSIWSMTLIAYDRYCVIVKGMARKPLTATAAVLRLMVVWTICGAWALM
PLFGWNRYVPEGNMTACGTDYFAKDWWNRSYIIVYSLWVYLTPLLTIIFSYWHIMK 0
0 AVAAHEKAMREQAKKMNVASLRNSEADKSKAIEIKLAKVALTTISLWFFAWTPYTIINYAGIFESMHLSPLSTICGSVFAKANAVCNPIVYGLS 2
1 HPKYKQVLREKMPCLACGKDDLTSDSRTQATAEISESQA* 0
>LMS_anoGam Anopheles gambiae (mosquito) Ecdy.Inse.Dipt XM_319247 full G? most introns obliterated
0 MPYYGPMQQPGLWGQPVANLTVVDKVPPEIMHLVDPHWSQFPPMNPLWHSIIGFVIFVLGVVSIIGNGMVIYIFSTAKSLRTPSNLFIVNLALSDFLMMGTNAFTMVYNCWFETWSLG
LLMCDLYAFFGSLFGCCSIWTMTMIALDRHNVIVHGLSGKPLTNTGAILRILLCWLIGVVWGILPMLGWNRYVPEGNMTACGTDYLTDDWFHKSYILVYSVFVYYTPLFTIIYAYFFIIK 0
0 AVSAHEKNMREQAKRMNVQSLRSSDDGKSTEMKLAKVALVTISLWFMAWTPYTVINYTGVFKTASITPLATIWGSVFAKANAVYNPIVYGISHPKY
RAALLRRFPSLACSDGPPADDKSLASEASGITSAGNPTTA* 0
>LMS2_droMel Drosophila melanogaster (fruitfly) Ecdy.Inse.Dipt M12896 full G? RH2 CG16740-RA Rh2 ocellar-specific
0 MERSHLPETPFDLAHSGPRFQAQSSGNGSVLDN 0
0 VLPDMAHLVNPYWSRFAPMDPMMSKILGLFTLAIMIISCCGNGVVVYIFGGTKSLRTPANLLVLNLAFSDFCMMASQSPVMIINFYYETWVLGPLWCDIYAGCGSLFGCVSIWSMC
MIAFDRYNVIVKGINGTPMTIKTSIMKILFIWMMAVFWTVMPLIGWSAYVPEGNLTACSIDYMTRMWNPRSYLITYSLFVYYTPLFLICYSYWFIIAAVAAHEKAMREQAKKMNVKSL
RSSEDCDKSAEGKLAKVALTTISLWFMAWTPYLVICYFGLFKIDGLTPLTTIWGATFAKTSAVYNPIVYGIS 2
1 HPKYRIVLKEKCPMCVFGNTDEPKPDAPASDTETTSEADSKA* 0
>LMS_rhoPro Rhodnius prolixus (kissing_bug) Ecdy.Inse.Hemi genomic full G?
0 MAQPIGPSFAAYQWGQSANPSANRSVVDMVPPEMLSMVDAHW 2
1 YQFPPLNPLWHGILGFVIGVLGIISIVGNGMVIFIFSSTKTLRTPSNLLVVNLAFSDFLMMFTMSPPMVINCYNETWVL 1
2 GPLMCELYGMLGSLFGCASIWTMTMIALDRYNVIVK 0
0 GISAKPMTNKTAMLRILLVWAFSIMWTVFPFFGWNR 2
1 YVPEGNMTACGTDYLTKNWVSRSYILVYSVFVYFLPLFTIIYSYFFILQ 0
0 AVSAHEKQMREQAKKMNVASLRSAEAANTSAEAKLAK VALMTISLWFMAWTPYLVINYSGIFETISISPLFTIWGSLFAKANAVYNPIVYAIR 2
1 HPKYKQALEKKFPSLSCASPQDDTTSVATGVTTSTDDKAPSA* 0
>LMS_acyPis Acyrthosiphon pisum (aphid) Ecdy.Inse.Hemi SCAFFOLD6053 full G?
0 MLNKIGSHYERQENWVAEGGFGNETVVDRVPADMMHLIDPSW 2
1 YQFPPMESMWYKWLGVTIFFLGILSVVGNGMVIYIFTCTKNLRTPSNLLIVNLAFSDFCLMFTMCPAMVWNCFYETWMF 1
2 GPFACELYAMFGSLFGVTSIWTMVFIALDRYNVIVK 0
0 GLSAKPMTTKLALLQIFCIYLHGLFWTLTPFFGWSR 2
1 YVPEANMTACGTDYLTLAWHSRSYVLVYAIFAYYLPLLVIIYAYYFIVK 0
0 AVASHEKSMREQAKKMNVSSLRSGDQSNTSAEFKLAKVALMTISLWFMAWTPYMVINFAGIFQLMTIDPLFTIWGSVFAKANAVYNPIVYAIS 2
1 HPKYRLALDKKFPCLVCGKLEDDRSDSKSVASAQTTISEDKV* 0
>LMS_homCoa Homalodisca coagulata (sharpshooter) Ecdy.Inse.Hemi AY588065 full G?
MSLISEPSFSAYSWASQGGFGNQTVVDKVPPEMLYLVDAHWYQFPPMNPLWHSLLGFAMVVLGFIAVTGNGMVVYIFSCTKALRTPSNLLVVNLAFSDFLMM
FTMAPPMVLNCYYETWVLGPFMCELYAMFGSILGCTSIWTMVMIANDRYNVIVKGLSAKPMTIKSALARILFCWAHSLIWCLAPFLGWGRYVPEGNMTACGTDYLTPDWISKSYIL
VYSLFCYFMPLFLIIYSYWFIVQAVSAHEKAMREQAKKMNVASLRSSDAANTSAEHKLAKVALMTISLWFCAWTPYLVINYAGIFQALTISPLFTIWGSVFAKANACYNPIVYAIS
HPKYRAALNKKFPSLVCGATEAPASTSDGASVASGATTLTEDKSAAA*
>LMSa_nasVit Nasonia vitripennis (jewel_wasp) Ecdy.Inse.Hyme XM_001606013 full G? 22063-23541 - strand of AAZX01007316 --
0 MGPSFLTLTAMAQRGGYGGGGGFGGGFNNQTVVDKAPPEIHHMIDPYWYQFPPMNPLWYGILGFVIGCLGCISVAGNGMVVYIFASTKSLRTPSNLLVINLAFSDFCMMFTMSPPM 0
0 VINCYYETWVFGPLMCEIYALCGSIFGCGSIWTMCMIAFDRYNVIVKGLSAKPMTINGSLLRILGIWLMASIWTIAPMFGWNR 2
1 YVPEGNLTACGTDYFSKDWVSRSYIVVYSFFVYFLPLFMIIYSYYFIIKAVSAHEKNMREQAKKMNVASLRQGDSQSAENKLAK 0
0 IALMTISLWFMAWTPYLVINWAGIFDLARLTPLFTIWGSVFAKANAVYNPIVYGIS 2
1 HPKYRAALFARFPSLACAGDAPAGAASDAVSTTSGVTTLTDHDKSNA* 0
>LMSb_nasVit Nasonia vitripennis (jewel_wasp) Ecdy.Inse.Hyme AAZX01007316 full G? tandem pair to LWSa fairly diverged
0 MEHPIVAAGVNATGEFDASSGSASSTTTMVTTAAVQVASTIGPHFARQVMRGFGNLTVVDKVPPEMLHLVGPHW 2
1 YQFPPLWPIWHKLLGVVMIFIGVLGWCGNGMVVYIFLVTPSLRTPSNLLVINLAFSDFVMMIIMSPPMVVNCWYETWIL 1
2 GPLMCDIYALIGSLCGGASIWTMTAIAYDRYNVIVK 0
0 GMSGTPLTIPRALVQIVLIWTHGLIWAMLPLFGWNR 2
1 YVPEGNMTSCGTDYVSDDWLGKSYILVYSIFVYYTPLFSIILCYWHIVS 0
0 AVAAHERGMREQAKKMNVASLRSGDQSGESAEVKLAK 0
0 VAVTTISLWFLAWTPYLVTNYMGIFAKQHVSPLFTIWASLFAKTNACYNPIVYGIS 2
1 HPKYRAGLKVKCPCLVFGDTEDKPKPAAATPAADAASTHSKA* 0
>LMSa_apiMel Apis mellifera (bee) Ecdy.Inse.Hyme NM_001077825 16291092 full Gq rhabdomeric long wavelength ocelli not compound
0 MDTLNITTSFFIEVMPSNISTLTTTGPQFARQLMRFNNQTVVSKVPEEMLHLIDLYW 2
1 YQFPPLDPLWHKILGLVMIILGIMGWCGNGVVVYVFIMTPSLRTPSNLLVVNLAFSDFIMMGFMCPPMVICCFYETWVL 1
2 GSLMCDIYAMVGSLCGCASIWTMTAIALDRYNVIVK 0
0 GMSGTPLTIKRAMLQILGIWLFGLIWTILPLVGWNR 2
1 YVPEGNMTACGTDYLSQDWTFKSYILVYSFFVYYTPLFTIIYSYYFIVS 0
0 AVAAHEKAMKEQAKKMNVTSLRSGDNQNTSAEAKLAK 0
0 VALTTISLWFMAWTPYLVINYIGIFNRSLITPLFTIWGSLFAKANAIYNPIVYGIS 2
1 HPKYRAALKEKLPFLVCGSTEDQTAATAGDKASEN* 0
>LMSa_attCep Atta cephalotes (ant) Ecdy.Inse.Hyme wgs ADTU01020830 16601190 full iMet uncertain 80% bee
0 MAFADVTRTIGPRAMQQIMSFNNKTVVNKVPPDMMHLIDPHW 2
1 YQFPPMNPMWHKILGLVMIVLGFMGWCGNGVVVYIFLMTPSLRTPSNLLIVNLAFSDFIMMIIMTPHMMINCYYETWIL 1
2 GPLMCDMHAMVGSLCGCASIWTMTAIALDRYNVIVK 0
0 GMAGKPLTIKKALLEILIIWLFASIWAILPIVGWNR 2
1 YVPEGNMTACGTDYLTKDWSSKSYILVYSIFVYYMPLLIIIYSYYFIVS 0
0 TVAAHERTMREQAKKMNVQSLRSGDNQNISAEAKLAK 0
0 VALMTISLWFMAWTPYLVINYVGIFGIAKISPLFTIWGSLFAKANAIYNPIVYGIR 2
1 HPKYRAALKEKLPFFVCGSTEDPSVAAKTAETSSTTTT* 0
>LMSb_apiMel Apis mellifera (bee) Ecdy.Inse.Hyme U26026 full G? 5 exonsArthropoda Insecta 540 complete genNow
0 MIAVSGPSYEAFSYGGQARFNNQTVVDKVPPDMLHLIDANWYQYPPLNPMWHGILGFVIGMLGFVSVMGNGMVVYIFLSTKSLRTPSNLFVINLAISDFLMMFCMSPPM 0
0 VINCYYETWVLGPLFCQIYAMLGSLFGCGSIWTMTMIAFDRYNVIVKGLSGKPLSINGALIRIIAIWLFSLGWTIAPMFGWNR 2
1 YVPEGNMTACGTDYFNRGLLSASYLVCYGIWVYFVPLFLIIYSYWFIIQAVAAHEKNMREQAKKMNVASLRSSENQNTSAECKLAK 0
0 VALMTISLWFMAWTPYLVINFSGIFNLVKISPLFTIWGSLFAKANAVYNPIVYGIS 2
1 HPKYRAALFAKFPSLACAAEPSSDAVSTTSGTTTVTDNEKSNA* 0
>LMSb_attCep Atta cephalotes (ant) Ecdy.Inse.Hyme wgs ADTU01020829 18362345 full 78% bee
0 MSFVSGPSHAAYTWAAQGGGFGNQTVVDKVPPEMLHMVDVHWYQFPPMNPLWHGLLGFAIGVLGTISIIGNGMVIYIFTTTKSLRTPSNLLVVNLAISDFLMMLWMSPAM 0
0 VINCYYETWVLGPLFCELYGMMGSLFGCGSIWTMTMIAFDRYNVIVKGLSAKPMTIKGALIRIFAIWLFTILWTIAPLFGWNR 2
1 YVPEGNMTACGTDYLTKDIVSRSYILFYSIFVYFMPLFLIIYSYFFIIQAVAAHEKNMREQAKKMNVASLRSAENQSTSAECKLAK 0
0 VALMTISLWFMAWTPYLIINFAGIFETTKISPLFTIWGSLFAKANAVYNPIVYGIR 2
1 HPKYRAALFQRFPSLACATEPAPGADTMSTTTTVTEGEKSVA* 0
>LMS_manSex Manduca sexta (moth) Ecdy.Inse.Lepi L78080 full G?
MDPGPGLAALQAWAAKSPAYGAANQTVVDKVPPDMMHMIDPHWYQFPPMNPLWHALLGFTIGVLGFVSISGNGMVIYIFMSTKSLKTPSNLLVVNLAFSDFL
MMCAMSPAMVVNCYYETWVWGPFACELYACAGSLFGCASIWTMTMIAFDRYNVIVKGIAAKPMTSNGALLRILGIWVFSLAWTLLPFFGWNRYVPEGNMTACGTDYLSKSWVSRSY
ILIYSVFVYFLPLLLIIYSYFFIVQAVAAHEKAMREQAKKMNVASLRSSEAANTSAECKLAKVALMTISLWFMAWTPYLVINYTGVFESAPISPLATIWGSLFAKANAVYNPIVYG
ISHPKYQAALYAKFPSLQCQSAPEDAGSVASGTTAVSEEKPAA*
>LMS_bomMor Bombyx mori (moth) Ecdy.Inse.Lepi BAAB01068714 11549248 full G? Bcop boceropsin Bomopsin1 tandem misassembly CK529859 hemocyte larva CK552244 fat body (pupa)
0 MISLDPGPGMAALQAWGGQVAAYGAANQTVVDKVPPDMLHMVDPHW 2
1 YQFPPMNPLWHALLGFTIGVLGFISISGNGMVIYIFMSTK 0
0 SLKTPSNLLVVNLAFSDFLMMCAMSPAMVVNCYNETWVF 1
2 GPFACELYACAGSLFGCASIWTMTMIAFDRYNVIVKGIAAKPMTNNGALLRILGIWAFSLAWTLAPFFGWNR 2
1 YVPEGNMTACGTDYLSKDWFSRSYILIYSVFVYFAPLLLIIYSYFFIVQ 0
0 AVAAHEKAMREQAKKMNVASLRSSEAANTSAECKLAK 0
0 VALMTISLWFMAWTPYLVINYTGVFESAPISPLATIWGSLFAKANAVYNPIVYGIR 2
1 HPKYQAALYARFPSLQCQSAPPDDGGSVASGATAVSEEKPAA* 0
>LMS_papXut Papilio xuthus (butterfly) Ecdy.Inse.Lepi AB007424 9547302 full G? Rh2
MAIANLEPGMGASEAWGGQAAAFGSNQTVVDKVTPDMMHLIDPHWYQFPPMNPMWHGLLGFTIGVLGFISITGNGMVVYIFTSTKSLKTPSNLLVVNLAFSD
FLMMLCMAPPMLINCYYETWVFGPLACELYACAGSLFGSISIWTMTMIAFDRYNVIVKGIAAKPMTINGALLRILGIWLFSLAWTIAPMLGWNRYVPEGNMTACGTDYLSKSWLSR
SYILVYSIFVYYTPLLLIIYSYFFIVQAVAAHEKAMREQAKKMNVASLRSSEAANTSAECKLAKVALMTISLWFMAWTPYLVINYTGVFETAPISPLATIWGSVFAKANAVYNPIV
YGISHPKYRAALYQKFPSLACQPSAEETGSVASGATTACEEKPSA*
>LMS_schGre Schistocerca gregaria (locust) Ecdy.Inse.Orth X80071 full G?
MASASLISEPSFSAYWGGSGGFANQTVVDKVPPEMLYLVDPHWYQFPPMNPLWHGLLGFVIGVLGVISVIGNGMVIYIFSTTKSLRTPSNLLVVNLAFSDFL
MMFTMSAPMGINCYYETWVLGPFMCELYALFGSLFGCGSIWTMTMIALDRYNVIVKGLSAKPMTNKTAMLRILFIWAFSVAWTIMPLFGWNRYVPEGNMTACGTDYLTKDWVSRSY
ILVYSFFVYLLPLGTIIYSYFFILQAVSAHEKQMREQRKKMNVASLRSAEASQTSAECKLAKVALMTISLWFFGWTPYLIINFTGIFETMKISPLLTIWGSLFAKANAVFNPIVYG
ISHPKYRAALEKKFPSLACASSSDDNTSVASGATTVSDEKSEKSASA*
>BCR_limPol Limulus polyphemus (horseshoe_crab) Ecdy.Chel.Mero FJ791252 full G? ventral eye
MSTGSYFIGNSTAPRSSGWWSYDPGLSVRDTAPENIKHLISDHWSKFPAVNPMWHYLLGLIYIVLGIASLTGQSVVLYLFAKTKPLRTPANMLIVNLAFSDF
MMMITQFPVFIINCLGGGAWQLGPLLCEITGFAGGLFGYGSIVTLAVISIDRYNVIVRGFSASPLTHARSAVFILVIWAWTLGWALPPFFGWGRYVPEGILNSCSFDYLTRDWATV
SYIMGCWICEYALPLMVIIYCYIFIVKAVCDHERHLREQAKKMNVASLRSNVDTQKASAEMRIAKVALVNVLLWVVSWTPYAAIAMIGIAGDQMLITPLRSALPALAGKAASVYNP
IVYAISHPKFRLAMQKEIPCCCINEPQPQSDTSSEMSTKTSVATVNGEDSTAGGTTNN*
>BCR_triGra Triops granarius (tadpole_shrimp) Ecdy.Crus.Bran BAG80976 18984904 full G? RhA
MAAYTEAWNASEEILVRMARAVPSVAWGYPAGVSIADLVPSDMKTMVHSHWNKFPPVNPMWHYLLGMVYIILGTVSIAGNSLVISLFTKTKELRTPANMFVVNLAFSDLCMMITQFPMFVYNCFNGGMWLFGPFLCELYA
ATGAVFGLCSICTLACIAFDRYNLIVKGMSGPKMTSKRATILIAFCWAYAIGWSLPPFFGWGRYIPEGILDSCSFDYLTRDSSTKSFGLCLFFFDYVTPLSIIVFAYFHIVRAIFEHEKILREQAKKMNVTSLRSNADQN
AQSAEIRIAKVALINISLWVAMWTPYATIVLQGLLGNQENITPLVSILPALIAKSASIYNPVIYAISHPRYRVALQQKLPWFCIHEEEKKPISDTDSAKTEASSS*
>BCR2_triLon Triops longicaudatus (tadpole_shrimp) Ecdy.Crus.Bran BAG80981 18984904 full G? RhA
MATYTEAWNASEEILVRMVRAAPSVAWGYPTGVSIVDLVPSDMKTMVHSHWSKFPPVNPMWHYLLGLVYIVLGTVSIAGNSLVISLFTKTKELRTPANMFVVNLAFSDLCMMITQFPMFVYNCFNGGMWLFGPFLCELYA
ATGAVFGLCSICTLACIAYDRYNLIVKGMSGPKMTSKRATILIAFCWSYAIGWSLPPFFGWGRYIPEGILDSCSFDYLTRDSSTKSFGLCLFFFDYITPLSIIVFAYFHIVRAIFEHEKILREQAKKMNVTSLRSNADQN
AQSAEIRIAKVALINISLWVAMWTPYATIVLQGLLGNQENITPLVSILPALIAKSASIYNPVIYAISHPRYRIALQQKLPWFCIHEEEKKPISISDTDSAKTETSSS*
>BCR1_triGra Triops granarius (tadpole_shrimp) Ecdy.Crus.Bran AB293431 18984904 full G?
MANASHYEALQQEFNPWALPESFTLYAYAPEDVRAFLHPHWHNFPATHPAIYYLFGLVYLVLGVTSVG
GNYLVLRIFTKFQELRRPSNVLVINLALSDMLLMLTLFPECVYNFLSGGPWRFGDLGCQIHAFCGALFGYNQ
ITTLVFISYDRFNVIVRGMGGTPLTYARVSAMVAFSWLWATGWSVAPLVGWGGYALDGMLGTCSFDYVTR
TWNNRSHILAATAFMWVIPVLIIAGCYWFIVQAVFKHEAELKAQAKKMNVASLRSNADQQQVSAEIRIAK
VAITNVVLWLSAWTPFMVISNLGIWADPQQVTPLVSSLPVLLSKTSCSYNPLVYAISHPKYRECLKTLVPWICIVLPNDRRGGDNVSSSSSRTEASGKAETVDA*
>BCR2_triGra Triops granarius (tadpole_shrimp) Ecdy.Crus.Bran AB293429 18984904 full G?
MSSGVFNSTDPIALARVSAGSNAHQQVGYNILIKTDGLSVRDVAPLDMHHLLHSHWDAYPPADPRIHYLL
GMLYFFLGIAACMGNVLVLHIFGKHKNLRSPTNTLLMNLAFCDLMIFIGLYPEMLGNIFMNDGTWMWGDV
ACRIHAWFGLVFGFGQMQTLMYMSIDRYNVIVKGLSAQPLTYKKVTQWLAQVWIVSLFWGTAPFFGFGNF
ALDGILNTCSFDYFSRDMLSMSYIVSACVWAYVIPLIVIIFCYTFIVRAVFEHEETLRQQAAKMNVTSLR
SSANSEDTSAEFRIAKIAMINVCLWLWAWSPFTIVSFIGIFGNQAIITPYLSSLPVILAKTSSVYNPIVYALSHPRYQAALKEEFAWLCVKTNSGNSGSSDTKSSVTMESSQPA*
>BCR3_triGra Triops granarius (tadpole_shrimp) Ecdy.Crus.Bran AB293432 18984904 full G?
MMHNFSEPRYEAQVVRYGDFAPGVSVRDMAPENVRYMVHLHWEKFPPPDPRVHTALGALYLIMGVMSAVG
NVLVLYIFGKYKSLRSPTNVLVMNLAFCDLGLFVGLYPELLGNIFINNGPWMWGDVACKIHAWCGLAFGF
GQMQTLMFVSMDRYYVIVKGLKAPPLTYWKVSVWLAMVWIVSIFWATSPFFGFGNLSVDGLLNTCSYDYY
TRDLPTVAYIVGSCVHAYVLPLAVIIFCYSYIVQAVFHHERQLREQAAKMNVASLRSSGGKQDEMSAEFR
IAKIALINCCLWLWAWTPFTVISFMGVLHDDQSIINPYVSSLPVLLAKTSAVYNPIVYGLSHPKFQQCLREEFGWNIGLPKKKDNDSKSVTSVETAMT*
>BCR1_triLon Triops longicaudatus (tadpole_shrimp) Ecdy.Crus.Bran AB293434 18984904 full G?
MSSSGFNSTDPIALARVSAGSNAHQQVGYNILIKTDGLSVRDVAPLDMHHLLHSHWDSYPPADPRIHYLL
GMLYFFLGIAACVGNVLVLHIFGKHKNLRSPTNTLLMNLAFCDLMIFIGLYPEMLGNIFMNDGTWMWGDI
ACRLHAWFGLVFGFGQMQTLMYMSIDRYNVIVKGLSAQPLTYKKVTQWLAQVWIVSLFWGTAPFFGFGNF
ALDGILNTCSFDYFTRDMPAMSYIVGACVSAYVIPLIVIIVCYTFIVRAVFEHEETLRQQAAKMNVTSLR
SSASAEDTSAEFRIAKIAMINVCLWLWAWSPFTIVSFIGIFGNQAIITPYLSSLPVILAKTSSVYNPIVYALSHPKYQAALKEEFAWLCVKTNAGNSGSSDTKSSVTMESNQPA*
>BCR2_braKug Branchinella kugenumaensis (fairy_shrimp) Ecdy.Crus.Bran AB293438 18984904 full G? Rhd
MLNNSEPSFAAYSVADGIWYPAGTKQIDGAPADVIAMTHAHWKQFPPSNPAWNYLFGVIYFFLWIVNHI
GNGLVIWIFLKTKSLRTPSNMLIVNLAIADFFMMLTQSPLYIISAFTSRWWIWGHFWCRFYGYTGGITGIA
AIFTMVFIGYDRYNVIVKGMNGTKITKGMAFIMILWTWIYANAFCLPAMLEVWGNFSPEGLLSTCSFDYL
NDNKFHGYFYTMYIFTGAYCVPMLLLMFFYSQIVKAVWAHEASSRAQAKKMNVESLRSNADANAESAEMR
IAKVALTNVLLWVCIWTPYAFVAVTGAFGNRQILTPLVAQLPSLICKMASCLNPLVYAISHPKYRQVLQK
ELPWFCIHEPEDKKSDATSVGSATTTATA*
>BCR3_braKug Branchinella kugenumaensis (fairy_shrimp) Ecdy.Crus.Bran AB293437 18984904 full G?
MLNFSEPRFAAYSVAEGVWYPPGTTQIDGAPADIVALTHAHWKKFPPSNPAWNYLFACLYFFLWVINHI
GNGLVIKIFLKTKSLRTPSNMLIVNLAIADFFMMLTQSPLFIISAFSSRWWIWGHFWCRFYGYTGGITGIA
AIFTLVFIGYDRYNVIVKGMSGKRISKGMAFGMIVWTWVYANVFCLPPMLQVWGDFSPEGMLSTCSFDYL
NENRLHGPIFTGYIFFGAYCVPMFLLFFFYSQIVKAVWAHEAALKAQAKKMNVESLRSNADANAESAEVR
IAKVALTNVLLWICIWTPYAFVAVTGAFGNRQILTPLVAQLPSLICKCASSLNPIVYAISHPKFRQVIQK
DYPWFCIHEPESSADTKSVTSGQTQVAA*
>BCRa_dapPul Daphnia pulex (water_flea) Ecdy.Crus.Bran AB293433 18984904 full G? RhA
0 MSNNLSSGYSSVAYRSEGASVLWGYPPGLSIVDLVPDDMKEFIHPHWNKFPPVNPMWHYL 2
1 LGVIYVILGITSVT 1
2 GNSLVVHLFAKTRDLRTPANMFVINLAFSDLCMMITQFPMFVFNCFNGGVWLFGPLFCELYACTGSIFGLCSICTMAAISYDRYNVIVNGMNRRRMTY 1
2 GRAGGLILFCWIYAIGWSIPPFVGWGKYIPEGILDSCSFDYLTRDTM 0
0 TISFTCCLFAFDYCVPLIIIIFCYYHIVRAIVHHEDALRDQAKKMNVSSLRSNADQKSQSAEIRVAKIAMMNITLWVAAWTPYAAICLQGAVGNQDKITPLVTILPALIAKSASIFNPVVYAISHPKYRL 0
0 ALQKALPWFCIHEKEEKEPPQDRREDSQSIATTNTNSSDVSLP* 0
>BCRa_hemSan Hemigrapsus sanguineus (crab) Ecdy.Crus.Mala D50583 9318091 full G? BcRh1 compound eye R1-R7 blue-green 480nm
MANVTGPQMAFYGSGAATFGYPEGMTVADFVPDRVKHMVLDHWYNYPPVNPMWHYLLGVVYLFLGVISIAGNGLVIYLYMKSQALKTPANMLIVNLALSDLI
MLTTNFPPFCYNCFSGGRWMFSGTYCEIYAALGAITGVCSIWTLCMISFDRYNIICNGFNGPKLTQGKATFMCGLAWVISVGWSLPPFFGWGSYTLEGILDSCSYDYFTRDMNTIT
YNICIFIFDFFLPASVIVFSYVFIVKAIFAHEAAMRAQAKKMNVTNLRSNEAETQRAEIRIAKTALVNVSLWFICWTPYAAITIQGLLGNAEGITPLLTTLPALLAKSCSCYNPFV
YAISHPKFRLAITQHLPWFCVHEKDPNDVEENQSSNTQTQEKS*
>BCRb_hemSan Hemigrapsus sanguineus (crab) Ecdy.Crus.Mala D50584 9318091 full G? BcRh2 compound eye R1-R7 blue-green 480nm
MTNATGPQMAYYGAASMDFGYPEGVSIVDFVRPEIKPYVHQHWYNYPPVNPMWHYLLGVIYLFLGTVSIFGNGLVIYLFNKSAALRTPANILVVNLALSDLI
MLTTNVPFFTYNCFSGGVWMFSPQYCEIYACLGAITGVCSIWLLCMISFDRYNIICNGFNGPKLTTGKAVVFALISWVIAIGCALPPFFGWGNYILEGILDSCSYDYLTQDFNTFS
YNIFIFVFDYFLPAAIIVFSYVFIVKAIFAHEAAMRAQAKKMNVSTLRSNEADAQRAEIRIAKTALVNVSLWFICWTPYALISLKGVMGDTSGITPLVSTLPALLAKSCSCYNPFV
YAISHPKYRLAITQHLPWFCVHETETKSNDDSQSNSTVAQDKA*
>BCR_porPel Portunus pelagicus (sand_crab) Ecdy.Crus.Mala EF110527 19040762 full G? horrible distal frameshifts
MANSTGPQMAFYGSQDMTYGYPEGVSIVDFVRPEIKPYVHQHWYNYPPVNPMWHYLLGVIYLCLGFISIIGNGMVIYLFAKCQALRTPANILVVNLALSDLI
MLTTNVPFFTYNCFNGGVWMFSATYCEIYGCLGAITGVTSTWLLCMISFDRYNIICNGFNGPKLTNGKAIILAFISWAISVGFGIAPLFGWGKYILEGILTSCSYDYLTQDFNTRS
YNIIIFVFDYFLPAAIIIFSYVFIVKAIFAHEAAMRAQAKKMNVTnLRSGEAESQRAEIRIARTALVNVSLWFICwTPYALISLQgvlgdlsginlLVTTLPALLARSCSW*</font>
<font color ="red">>RGR1_homSap Homo sapiens (human) Deut.Euth.Euar NM_001012720 18474598 full G? syn(+PCDH21 -LRIT1 -GRID1 -WAPAL) RPE Mueller exon-skipping splice
0 MAETSALPTGFGELEVLAVGMVLLVE 1
2 ALSGLSLNTLTIFSFCKTPELRTPCHLLVLSLALADSGISLNALVAATSSLLR 2
1 RWPYGSDGCQAHGFQGFVTALASICSSAAIAWGRYHHYCT 1
2 RSQLAWNSAVSLVLFVWLSSAFWAALPLLGWGHYDYEPLGTCCTLDYSKGDR 2
1 NFTSFLFTMSFFNFAMPLFITITSYSLMEQKLGKSGHLQ 0
0 VNTTLPARTLLLGWGPYAILYLYAVIADVTSISPKLQM 0
0 VPALIAKMVPTINAINYALGNEMVCRGIWQCLSPQKREKDRTK* 0
>RGR1_ornAna Ornithorhynchus anatinus (platypus) Deut.Prot.Mono genomic frag G? last D in DRY motif Atlantogenata ERY other placentals GRY
0 1
2 ALLGLCLNGLTIASFRKIKELRTPSNLLVVSLALADSGICLNALMAALSSFLR 2
1 HWPYGAEGCRLHGFQGFATALASISLSAAIGWDRYLRHCS 1
2 RSKPQWGTAVSTVLFAWGFSAFWSMMPILGWGQYDYEPLRTCCTLDYSKGDR 2
1 NFTTYLFAVAFFNFVIPLFIMLTSYQSIEQRFKKSGLFK 0
0 LNTRLPTRTLLFCWGPYALLCFYATVENVTFISPKLRM 0
0 IPALIAKTVPVIDAFTYALRNEDYRGGIWQFLTGQKIERVEVENKIK* 0
>RGR1_galGal Gallus gallus (chicken) Deut.Saur.Arch NM_001031216 14985289 full G? syn(+PCDH21 -LRIT1 +CHAT -PARG) retinal ganglia
0 MVTSHPLPEGFTEIEVFAIGTALLVE 1
2 ALLGFCLNGLTIISFRKIKELRTPSNLLVLSIALADCGICINAFIAAFSSFLR 2
1 YWPYGSEGCQIHGFQGFLTALASISSSAAVAWDRYHHYCT 1
2 RSKLQWSTAISMMVFAWLFAAFWATMPLLGWGEYDYEPLRTCCTLDYSKGDR 2
1 NYITFLFALSIFNFMIPGFIMMTAYQSIHQKFKKSGHYK 0
0 FNTGLPLKTLVICWGPYCLLSFYAAIENVMFISPKYRM 0
0 IPAIIAKTVPTVDSFVYALGNENYRGGIWQFLTGQKIEKAEVDSKTK* 0
>RGR1_xenTro Xenopus tropicalis (frog) Deut.Amph.Anur BC135113 full G? retina G protein receptor syn(+PCDH21 -LRIT1 +CHAT -PARG)
0 MVTSYPLPEGFTETEVFAIGTTLLVE 1
2 ALLGLLLNGLTLLSFYKIRELRTPSNLFIISLAVADTGLCLNAFVAAFSSFLR 2
1 YWPYGSEGCQIHGFQGFVAALSSIGSCAAIAWDRYHQYCT 1
2 RSKLHWSTAVSVVFFIWGFSAFWSAMPLFGWGEYDYEPLRTCCTLDYSKGDR 2
1 NYISYLFTMAFFEFLVPLFILMTAYQSIYQKMKKSGQIR 0
0 FNTSMPVKSLVFCWGPYCLLCFYAVIQDATILSPKLRM 0
0 IPALLAKTSPAVNAYVYGLGNENYRGGIWQYLTGQKLEKAETDNKTK* 0
>RGR1_cynPyr Cynops pyrrhogaster (newt) Deut.Amph.Batr FS290827 frag G? 20090923 lens regenerating iris
0  GFTEIEVFGLGTALLIE 1
2 ALLGFILNGLTLLSFYKIRSLRTPHNFLIVSLALADTGVCINAFIAAFSSFLR 2
1 YWPYGSEGCQIHGFQGFVTALSSISSCGVIAWDRYNQYCT 1
2 RTKLQWGTAISLVSFVWAFSAFWSVMPLLGWGQYDYEPLRTCCTLDYTKGDK 2
1 NFISYLFPLAFFEFVIPLFIMLTAYQSVEQKFKKTGQHK 0
0 FNTGLPVKTLVMCWGPYSLLCFYATIENATTISPKIRM 0
0 LPAILAKTAPAINAFLYGMGNESYRGGIWQFlTGQKIEKAEVDNKTK* 0
>RGR1_gasAcu Gasterosteus aculeatus (stickleback) Deut.Acti.Perc genomic full G? syn(+PCDH21 -LRIT1 +CHAT -PARG) retinal ganglia
0 MVSSYPLPDGFTDFDVFSLGSCLLVE 1
2 GLLGILLNAVTIAAFLKVRELRTPSNFLVFSLAVADIGISMNATIAAFSSFLR 2
1 YWPYGSDGCQTHGFQGFVTALASIHFIAAIAWDRYHQYCT 1
2 RTKLQWSSAITLAVFVWLFTAFWSAMPLIGWGEYDYEPLRTCCTLDYTKGDR 2
1 NYVSYLIPMAIFNMAIQVFVVMSSYQSIAQKFKKTGNPR 0
0 FNPNTPLKAMLFCWGPYGILAFYAAVENATLVSTKLRM 0
0 MAPILAKTSPTFNVFLYALGNENYRGGIWQLLTGEKIDVPQIENKSK* 0
>RGR1_calMil Callorhinchus milii (elephantfish) Deut.Chon.Holo genomic frag G? retina G protein receptor
0 EGFTDFEVFGLGTALLVE 1
2 GLVGLLLNGLTLLAFYKIKELRTPSNLLITSLALSDFGISMNAFIAAFSSFLR 2
1 YWPYGSEGCQTHGFHGFLMALASINACAAIAWDRYHQNCS 1
2 RSRLQWSSAITVTVFIWGIAAFWSAMPLLGWGVYDYEPLRTCCTLDYSKGDR 2
1 NFISFFIIMGSFEFIFPIFIMLSSYQSCKSKFKKNGQVK 0
0 FNTGLPVKTLIFCWGPYSLLCFYATIENITILSPKLRM 0
0 * 0
>RGRa_cioInt Ciona intestinalis (tunicate) Deut.Uroc.Tuni AB079882 12687683 full G? Ci-opsin3 syn(PPT1 NOMO2+ FOXC2- FAHD1-) larval photoisomerase
0 MEVNDKRVYGVLMGLL 1
2 GLLTITGYSLLFVIFAKRPDLKKKNKFLLSLATSDLLITVHVFASTIAAFAPQWPFGDLGCQ 0
0 VDAFIGMAPTFISIAGAALIAKDKYYRFCKPKM 1
2 VGRNYSFHVYLTWTMGIIGGALPFIGFGRYGFETDDVTWRTGCLLDFKSISA 2
1 KYSFYIILISTVWFVWPVYKLVSSYMKISTKINKFYP 0
0 LLFVVPVQMAIGLLPYAIYAMVSITIGVSAVPYFCVVINN 0
0 LAAKVFVGSNPFIYIYFDPELRESCKQIFCSPPAPTNDKISEDSKDE* 0
>RGRa_cioSav Ciona savignyi (tunicate) Deut.Uroc.Tuni genomic full G? Ci-opsin3 larval visual cycle photoisomerase
0 MDFSSKRTYGIAMAAL 1
2 GFIAWVGYGLLFVIFAKSPDLKKKNRFLFSLAVSDLLITIHVVASVVASFQSEWPFGSIGCQ 0
0 LDAFIGMAPTFISIAGAALVAKDKYYRICKPKM 1
2 LVGRNYSFSIYANWTLGIIGGLLPFFGFGQYGFETDDLSLRTGCLLDFKTVSA 2
1 KYRFYIVFISLVWFVWPLYKLTSHYIKISAKLDRFHP 0
0 LMFVVPLQMLVSLLPYAIYAMISITVGVSSAPYYLVAVNN 0
0 IAAKVFIGTNPFIYIYFDPELRLACKNLFKYSSTPVQDQIQDKKDE* 0
>RGRb1_cioInt Ciona intestinalis (tunicate) Deut.Uroc.Tuni AB078611 12373590 full G? CiNut entire neural tube
0 MEIDFGFARTVYGVALLLM 1
2 VFITLLGYAVYFGAIWRSKTLQTRHIWLTSLACGDIIMMVHLILESLSSLGMGHRPRQNFECQ 0
0 VGALVGLFSGYVTIASITWIAIDRYYRQCKPEK 1
2 VGVNYCFYVIIVWAMSFLAASGPALGFGAYESAEENTVKCLIDLNKKDT 2
1 NSRLYIILVSAVWFVYPFVKMILYNKKLVQEAKEPQP 0
0 MAFAVPLTFFLCYLPFAIYASLKITVGLPPLNSMVVASIY 0
0 MLPKVISVVNPYLYMRSDPELLAACRHVVGLTDGKKAV* 0
>RGRb2_cioInt Ciona intestinalis (tunicate) Deut.Uroc.Tuni genomic full G? retina G protein receptor
0 MELEFGITRTAYGIAMLMM 1
2 AAVATFGYSVYILAIWSSKKLQTKHIWLTSLACADLLMMVHLFMDGLSSFHQGRRPKGIFECQ 0
0 VSAHMGLFSGFVSIASMTWICIDRYYRKFKPEK 1
2 VGVNYCFYVIIVWAMSFLAASGPALGFGAYESAEENTVKCLIDLENTDM 2
1 NTIKYFVVVGFLFFFYPIFKMIKYNTKFAYKSEEEKA 0
0 VVIAAPVSFVLGYLPYLVYACLKLTIGLPPLNQASIAFL 0
0 YLLPKFISVMNPYMYMRSDPELLRAAKRVVNFDFDQKIE* 0
>RGRb3_cioSav Ciona savignyi (tunicate) Deut.Uroc.Tuni genomic full G? retina G protein receptor
0 MELEFGIIRTAYGIAMLLM 1
2 AVVATFGYSIYLRAIWSSRKLQTRHIWLTSLACADLIMMVHLFMDGLSSFHQGRRPKGNFECQ 0
0 ASALMGLFSGFVSIGSVTWICIDRYYRRYKPEK 1
2 AGLNYCFYVIIVWGLSFLAASGPAMGFGTYESAQENTVKCLIDLDNTDG 2
1 NTIKYFMVIGVLYFFYPIFKMVKYNTLAQATEVEKT 0
0 VVIAAPATFVIGYLPYLSYAILKLTIGLPPVNEAFIAFV 0
0 ILPKFISVLNPYMYMRSDPELLRAAKDVVNFNFYTKMD* 0
>RGR2_danRer Danio rerio (zebrafish) Deut.Acti.Otoc NM_001024436 full G? retina G protein receptor embryonic RPE brain gut embryo PA
0 MASYPLPEGFTDFDMFAFGSALLVG 1
2 GLLGFFLNAISVLAFLRVREMQTPNNFFIFNLAVADLSLNINGLVAAYACYLR 2
1 HWPFGSEGCQLHAFQGMVSILAAISFLGAVAWDRYHQYCT 1
2 KQKMFWSTSITISCLIWILAVFWAAMPLPAIGWGVFDFEPLRTCCTLDYSQGDR 2
1 GYITYMLTITVLYLAFPVLVLQSSYSAIHAYFKKTHHYR 0
0 FNTGLPLKALLFCWGPYVVVCSLACFEDVSVLSPRLRM 0
0 VLPVLAKTSPIFHAVLYAYGNEFYRGGVWQFLTGQKSADKKK* 0
>RGR2_tetNig Tetraodon nigroviridis (pufferfish) Deut.Acti.Perc genomic full G? retina G protein receptor eye
0 MAAYTLPEGFTEFDMFTFGTALLVG 1
2 GVLGFFLNAISIVSFLTVKEMRNPSNFFVFNLALADISLNVNGLIAAYASYLR 2
1 YWPFGQDGCSYHAFHGMISVLASISFMAAIAWDRYHQYCT 1
2 RQKLFWSTTLTMSSIIWILSIFWSAVPLMGWGVYDFEPMRTCCTLDYTRGDR 2
1 DYVTYMLTLVVLYLTFPAATMWSCYDSIYKHFKKVHQHR 0
0 FNTSMPLRVLLVCWGPYVVMCVYACFENVKVVSPKLRM 0
0 LLPVIAKTNPIFNALLYTFGNEFYRGGVWHFLTGHKIVDPVLKKSK* 0
>RGR2_gasAcu Gasterosteus aculeatus (stickleback) Deut.Acti.Perc genomic full G? retina G protein receptor eye
0 MAAFALPEGFTEFDMFTFGSALLVG 1
2 GLIGFFLNAISIASFLRVKEMWNPSNFFVFNLAVADICLNVNGLTAAYASYLR 2
1 YWPFGQDGCTFHAFQGMIAVLASISFMGVIAWDRYHQYCT 1
2 RQKLFWSTTLTMSAIIWILSIFWAAVPLMGWGVYDFEPMRTCCTLDYTKGDR 2
1 DYVTYMLTLVFLYLMFPALTMWSCYDAIHKHFKKIHLHK 0
0 FNTSTPLRVLLMCWGPYVLMCIYACFENVKVVSPKLRM 0
0 LLPVVAkTNPIFNALLYSFGNEFYRGGVWHFLTGQKMVDPVVKKSK* 0
>RGR2_oryLat Oryzias latipes (medaka) Deut.Acti.Perc genomic full G? retina G protein receptor whole embryo
0 MGTHTLPEGFTDFDMFTFGSALLVG 1
2 GLLGFFLNAISILAFLRVKEMRSPSSFLVFNLALADISLNINGLTAAYASYLR 2
1 YWPFGQEGCDYHGFQGMISVLASISFMAAIAWDRYHQYCT 1
2 RQKLFWSTSITISLIIWILSILWSAFPLMGWGVYDFEPMRIGCTLDYTKGDR 2
1 DYITYMLSLVFFYLMFPAFIMLSCYDAIYKHFKKIHYYR 0
0 FNTSLPLRVMLMCWGPYVLMCIYACFENVKLVSPKLRM 0
0 LPVIAKTNPFFNALLYSFGNEFYRGGVWNFLTGQKIVEPDVKKSKQK* 0
>RGR2_pimPro Pimephales promelas (minnow) Deut.Acti.Otoc genomic full G? retina G protein receptor liver brain PA
0 MASYALPEGFSDFDMFAFGSALLVG 1
2 GLLGFFLNLISVLAFLRVREIQTPNNFFIFNLAVADLSLNINGLVAAYASYLR 2
1 YWPFGSEGCQIHGFQGMVSILASISFLGAIAWDRYHLYCT 1
2 KQKMFWSTSGTISALIWILAVFWAALPLPAIGWGVFDFEPMRTCCTLDYTIGDR 2
1 NYISYMLTITVLYLAFPVLIMQSSYNGIYAHFKKTHHFK 0
0 FNTGLPLKMLLFCWGPYVLMCTYACFENASLVSPKLRM 0
0 VLPVLAKTSPIFHAAMYAYGNEFYRGGIWQFLTGQKPADKKK* 0</font>
<font color ="#9900FF">>PER1_homSap Homo sapiens (human) Deut.Euth.Euar NM_006583 17167409 full G? RRH peropsin syn(-CFI +NOLA1 +EGF -ELOVL6)
0 MLRNNLGNSSDSKNEDGSVFSQTEHNIVATYLIMA 1
2 GMISIISNIIVLGIFIKYKELRTPTNAIIINLAVTDIGVSSIGYPMSAASDLYGSWKFGYAGCQ 0
0 VYAGLNIFFGMASIGLLTVVAVDRYLTICLPDV 1
2 GRRMTTNTYIGLILGAWINGLFWALMPIIGWASYAPDPTGATCTINWRKNDR 2
1 SFVSYTMTVIAINFIVPLTVMFYCYYHVTLSIKHHTTSDCTESLNRDWSDQIDVTK 0
0 MSVIMICMFLVAWSPYSIVCLWASFGDPKKIPPPMAIIAPLFAKSSTFYNPCIYVVANKK 2
1 FRRAMLAMFKCQTHQTMPVTSILPMDVSQNPLASGRI* 0
>PER1_monDom Monodelphis domestica (opossum) Deut.Meta.Dide genomic full G? RRH peropsin syn(-CFI +NOLA1 +EGF -ELOVL6)
0 MFKNNSVKTLAPEKEGPSVFSPIEHKIVAAYLITA 1
2 GVISIVSNVIVLGIFVKYKALRTATNTIIINLAVTDIGVSSIGYPMSAASDLYGSWKFGYDGCQ 0
0 IYAGLNIFFGMASIGLLTAVAIDRYLTICQPDL 1
2 GRMTSYNYTLMILTAWVNGFFWALMPIVGWAGYAPDPTGATCTINWRKNDV 2
1 SFVSYTMTVITINFAMPLGVMFYCYYNVSQKMKQYSPSNCPDHINRDWSNQVAVTK 0
0 MSVVMILMFLLAWSPYSIVCLWASFGDPKEIPPAMAIVAPLFAKSSTFYNPCIYVAANKK 2
1 FRRAISAMIRCQTHQSMPISNALPMN* 0
>PER1_ornAna Ornithorhynchus anatinus (platypus) Deut.Prot.Mono XM_001506366 full G? RRH peropsin
0 MRRNDSANLLESEHHDRSAFSQTDHNIVAAYLITA 1
2 GIMSIVSNVIVLGIFVKFEELRTATNAIIINLAVTDIGVSGIGYPMSAASDLHGSWKFGHAGCQ 0
0 IYAGLNIFFGMSSIGLLTVVAVDRYLTICRPAI 1
2 GRKMTRSNYTAMILAAWMNGFFWASMPLLGWASYASDPTGATCTINWRKNDA 2
1 SFISYTMTVIAVNFAVPLIVMFYCYYNVSKAMRQYPASRVLENLNIDWSEQVDVTK 0
0 MSVVMILMFLMAWSPYSIVCLWSSFGDPKKISPAVAIMAPLFAKSSTFYNPCIYVVANKK 2
1 FRRAMLSMVQCQTHREITITDVLPMNRSRSPH* 0
>PER1_xenTro Xenopus tropicalis (frog) Deut.Amph.Anur genomic full G? RRH peropsin syn(-CFI +NOLA1 +EGF -ELOVL6)
0 METLAEVSTLLPAGTGTVNISDASSEVHSVFSQSEHNIVAAYLITA 1
2 GVISILSNIIVLGIFVKYKELRTATNAIIINLAFTDIGVSGIGYPMSAASDLHGSWKFGYVGCQ 0
0 IYAGLNIFFGMASIGLLTVVAIDRYLTICRPDI 1
2 GRRISGRHYTAMILAAWINAVFWSVMPVVGWSSYAPDPTGATCTINWRKNDV 2
1 SFVSYTMSVVAVNFVVPLMVMFYCYYNVSRTMKGYGSRSSLGGINADWSDQTDVTK 0
0 MSMVMIVMFLVAWSPYSIVCLWSSFGDPRKIPPAMAIIAPLFAKSSTFYNPCIYVIANKK 2
1 FRRAILSMVQCKSRQEVTLDNHFPMNVSQSTLTT* 0
>PER1_gasAcu Gasterosteus aculeatus (stickleback) Deut.Acti.Perc genomic full G? RRH peropsin syn(+GPR68 -GNPDA1 -ENPEP -C14orf100)
0 MGIDPEVNVTDDVTLYGGKSAFTQLEHNIVAGYLITA 1
2 GVISLFSNIVVLLMFWKFKELRTATNFIIINLAFTDIGVAGIGYPMSAASDIHGSWKFGYAGCQ 0
0 IYAALNIFFGMASIGLLTVVAIDRYLTICRPDI 1
2 GQKMTMQSYNLLILAAWLNAVFWSSMPVVGWASYAPDPTGATCTINWRQNDV 2
1 SFISYTMAVIAVNFVLPLSAMFYCYYNVSATVKRYKASNCLDSANIDWSDQMDVTK 0
0 MSIVMIIMFLVAWSPYSIVCLWASFGDPKTIPAPMAIIAPLFAKSSTFYNPCIYVIANKK 2
1 FRRAIIGMVRCQTRQRITINSQVPMTTSQQPLTQ* 0
>PER1_calMil Callorhinchus milii (elephantfish) Deut.Chon.Holo genomic frag G? RRH peropsin
1 LFVSYTMTVIAVNFVVPLSVMFFCYYNVSKTMSRFISSPSPENINLDWSDQLDVTK 0
0 MSVVMIVMFLLAWSPYSIVCLWASFGNPKLIPPAMAIIAPLFAKSSTFYNPCIYVIANKK 2
1 FRKAIMAMICCQNRQEITINHTLPMTISRVPLTE* 0
>PER1_braFlo Branchiostoma floridae (amphioxus) Deut.Ceph.Bran XM_002228504 12435605 full Go RRH peropsin Amphiop1
0 MNASPSSWLPSGELFTDSPENSSEWPWTDGPTDTAWHHHQTVDPVTYGGYLASAVYLTIT 1
2 GLIAFVGNIFAIIVFLTEKEFRKKEHNSFALNLAIADLSVCVFAYPSSTIS 1
2 GYAGEWMLGDVGCTIYGFLCFTFSLTSMVTLCAISVYRYIVICKPQY 1
2 AHLLTHRRTNYVILGIWLYALVFSVPPLFGVNRYTYEPIS 2
1 ITCSLDWNVQHVGETIYTAAVIIIVYVLNVSIMCFCYFNIIFKSANLKFAALASEKTRTAAKKDIWKTSM 0
0 MCLAMVVSFLIAWTPYAVSSTWDILTEEDLPIIATILPTMFAKSSCMMNPIIYSCCNGKFRQAALKTFSK 0
0 VGSSNKQNGQAQVEPRDPGFAVEPAGHQAFQMRVLPSSSAMTL* 0
>PER1_braBel Branchiostoma belcheri (amphioxus) Deut.Ceph.Bran AB050606 12435605 full G? RRH peropsin Amphiop1 introns from braFlo
0 MNASPSSWLSSGEFFTDSPENSSEWPWTDGPTDTTWRHHQSVDSVSYEGYLASAIYITLT 1
2 GLIAFFGNVITITVFLTEKEFRKKQQNGFVLNLAIADLSVCVFAYPSSAIA 1
2 GYAGRWVLGDVGCTIYGFLCFTFALVSMVTLCVISIYRYILICKPQY 1
2 AHLLTHRRTVYVIIGTWLYALVFTVPPLVGVKRYTYEPMQ 2
1 ITCSLDWNVQHPGEKAYIAAVLVIVYVLQVLIMCFCYFNIIFKSANLKFAALASEKTKMAAKKDTWKTSV 0
0 MCLTMVVSFLIAWTPYAVSSTWDILSAEDLPIIATILPSLFAKSSCMMNPIIYACCNTKFRQAAVKSFRK 0
0 LCGMCKQKVPLSTPQVVLAMQRNTEFTSTVEPTGQAFPMRVLPSISATHTAL* 0
>PER2_braFlo Branchiostoma floridae (amphioxus) Deut.Ceph.Bran XM_002209058 12435605 frag G? RRH peropsin Amphiop3
0 MIPTNNNTENNDLEWGLEKEHGVSATIMGVYLTIV 1
2 GLVSTVGNATVVLMFMLKWRQLCRKAPNLLIINLAAVDLCISVFGYPFSASSGFANQWLFSDAICT 0
0 LYGFSCFLLSMVSMHTLCLISAHRYITICRPEH 1
2 ASKLTMTRTILAVVGAWVYGISVAVPPLFGIA 1
2 GYTYESFGLSCTIDFHGTTVADMVYLSILIILCYVINVAVMGTCYFKIIRK 2
1 FSKHRFREVRDVRTSHQHSFERGVTL 0
0 RCILMTLFYLISWTPYTAVAVWTMVGPPPPVQLGMVAALTAKTHCAFNPILYMLMSE 0
0 VYRKLVLRTMCPCCFNKISNKLVRLPADDSKHSGNLDIFTVGYNTRDQAVQINKNAARRFCFVMET 0
0 ASDDLGIDDEVFAGQLGLCSRVKATEPGVEGFGGSEVPQSPSGTESEWSLSLLDFLPKRSSSKTAKASSLSETCSDNTVLSSAARK
MAFLESSHQQSDREVCCIENRQAPEDTKPCKFAIESLGVRLPHKCCTASQVAGAPSRYAGMIETFTDSKGKTKKKAAVSLSEIDVKKP
PPASKTWERRKTSKNTSRGQRVKRTFGKSRKHAYIVDC* 0
>PER2_braBel Branchiostoma belcheri (amphioxus) Deut.Ceph.Bran AB050607 12435605 full G? RRH peropsin Amphiop2 introns from braFlo
0 MIPTNNNTENNDLEWGLEKEHGVSATIMGVYLTIV 1
2 GLVATVGNATVVLMFIMKWRQLCRKAPNLLVINLAAANLCITIFGYPFSASSGYAHQWLFPDAICT 0
0 LYGFSCFLLSMVSMHTLCLISAHRYITICRPEH 1
2 ASKLTMNRTVLAVIGTWLYAIAVAVPPLFNIA 1
2 RYTYEPSGLSCTIDFRVTTVADLVYLGSLIVLCYVIHVAVMATCYFKIIRK 2
1 FSRHRFRQVRDIRTSHQRSFEMGVTM 0
0 RCILMTLFYLLSWTPYTAVCIWTMVGPPPPVVVSMAAALIAKTHCAFNPILYAFMSE 0
0 VYRKLVFRTMCPCCFNRISCKFVGTPTGGSKVSANPDIFTVDYNSRDQAVQINKAPSRRFCFVMET 0
0 SEDLGSDDTGLTGHSGLWRSGAEVEGLGGLQVTQSPSVSGSELSLSLLDFLPPKPSGRAVSAKLPSPPALNSERATCP
ESSQQPSDRPATGLRQYQKGDTTRSSVGDLILTEDDVTNLPPASETWGRKKSENPLSYRQTTRRTFGRSRKHSYIVD* 0
>PER3_braFlo Branchiostoma floridae (amphioxus) Deut.Ceph.Bran AB050610 12435605 full G? RRH peropsin Amphiop3
0 MDIPTETPYGAGDDPAGTGWRWAETDQNGFHKYDHLIVGLYLFVI 1
2 GIIGTVENGITLATFTKFRSLRSPTTMLLVHLAIADLGICIFGYPFSGASSLR 0
0 SHWLFGGVGCQWYGFNGMFFGMANIGLLTCVAVDRYLVICRQDL 1
2 VDKVNYNTYGVMAALGWLFAAFWAALPLVGWAEYSLEPS 1
2 GTACTINWQKNDSLYISYVTSCFILGFALPLAVMMFCYWQ 0
0 ASCFVNKVLKGDISGDLTFPVAVNVDWEYQNHFSK 0
0 MCLAMVAAFVVAWTPYSVLFLFAAFGNPADIPAWITLLPPLIAKSSALYNPIIYIIANRRFRSAIFSMVKGQNPDVE 0
0 TLFARDFRISPIEDTGKEMSSMGNANA* 0
>PER3_braBel Branchiostoma belcheri (amphioxus) Deut.Ceph.Bran AB050610 12435605 full G? RRH peropsin Amphiop3 introns from braFlo
0 MDIPTETPYGAEEDIGESAGWRWTETDKNGFHKYDHLIVGLYLFVI 1
2 GIIGTIENGITLATFSKFRSLRSPTTMLLVHLAIADLGICIFGYPFSGASSLR 0
0 SHWLFGGVGCQWYGFNGMFFGMANIGLLTCVAVDRYLVICRHDL 1
2 VDKVNYNTYGVMAALGWLFAAFWAALPLVGWAEYALEPS 1
2 GTACTINFQKNDSLYISYVTSCFVLGFVVPLAVMAFCYWQ
0 ASCFVSKVLKGDIAGDLTFPVAANVDWEYQNHFSK 0
0 MCLAMVAAFVVAWTPYSVLFLFAAFWNPADIPAWLTLLPPLIAKSSALYNPIIYIIANRRFRNAICSMMKGQDPDVE 0
0 DDEHADEHRVRSIEDNDKEIISMVNLNMTV* 0
>PER2a_strPur Strongylocentrotus purpuratus (sea_urchin) Deut.Echi.Eleu XM_778236 full Go RRH peropsin overshoots iMet spread across tandem
0 MAASVTESSATEAISRLEPEYMVPLTRTGYLLTAIYLTIV 1
2 GSIATVGNITVICVLCRYRTFRKRSINLLLINMAASDLGVSVAGYPLTTVSGYWGRWLFGDVGCQFYAFCVYTLSCSTISTHAAIAVYRYIYIVKTDL 1
2 RPKLTANFTSGVIVVIWVYAFFWTVTPFVGWSSYIYEPFGTSCSVNWVGRTISDISYMVACTIGVYLLQIFIMLYCYIRVAKK 2
1 IRGVDPGRTEEKDAGVVVFGRLRKREAKIDTHVTK 0
0 MCFMMMLTFIVVWAPYAVECLRAAHVHRISALSSVLPTMFAKSSCMVNPIIFLTSSSKFRQDLGKLWSRPSSQDSLQLEER
NKTQRSLYVRHSELGSAHGNDTASVYYEKERIYIGEMRATSIQKEAELLQRDPELLSIASSTNSDVKFVVRDRPKRYTKR
PVKPQGPRGPEMFTASGVTNKGSSTSDSGGQSTSSGTTGSKPKRSGRKASRQYSMKSQSEDTGEIFTLDGSALEMMSLRKL* 0
>PER2b_strPur Strongylocentrotus purpuratus (sea_urchin) Deut.Echi.Eleu XM_778236 17067569 full Go RRH peropsin no cdna inline tandem PER2_strPur
0 MNSFSEESYVTDPTTTQPTLFLTPLSQTGYLLTALYLTLV 1
2 GIVSTIGNITVLCVLCRYGTFRKRSVNILLMNMAVSDLGVSVAGYPLTAISGYRGRWVFADIGCQFSGFCVYALSCSTISTHAVVAIYRYIYIVKPYH 1
2 RPRLSSSTSCLAILCIWTFTLFWTITPFFGWSSYTYEPFGTSCSINWYGKSLGDLTYIICCVVFVFILPIIIMLYCYIGVAKK 2
1 IKGIDPLRTEERDIAVVFGRLRKHETKIDTRVTK 0
0 ICFMMMASFIVVWTPYAVGSIWASKIGKISASASVLPTMFAKSSCMINPIIFLTSSSKFRADLGKLWNRPSSLEHTIRVEERSREQRSFF
VRQSALPDAMVSRSASVYYDKERIYIGEMRAASIQKEADLLHRDPEAISIASSTSSSLQFVLKDRQNRYKKKAGEASKKGSNILHFPYDDTE
GSMINNLMRPRSHSVTSDNISRVFAPSLKRPTKKRSMSHPDIPSTSADIFTVSPTTIKNLQKQ* 0
>PER1a_sacKol Saccoglossus kowalevskii (acornworm) Deut.Hemi.Ente ACQM01133041 full G? RRH peropsin 7 ests + ACQM01133041
0 MVTTDSLANSTDEPVPSILTLQQHYAASVTLLAL 1
2 AVIGTVLSSVNFRMLLSNPDYCSKAGNFFLSLAVTDL 1
2 CVCIFETPFSAFSHHAGFWIFGDTACQLYAFFGIFFGLVNIFMVTFISLDRYWATCSPVE 1
2 VELKSKYYTRMTALGWMVALFWAAAPVFGWSRYaMEPSMASCSIDYMTNDFSYVTYITCLTLTCYVVPIVVMVYCYVKASKNIKYTGKVTEWAHENNATK 0
0 ISRLCVLQLVFCWSLYGFNCMWTVVADDVETLPKMLTVLAPILAKTTPILNSGLYFLHNKKFRGAAVDMFKAKEE* 0
>PER1b_sacKol Saccoglossus kowalevskii (acornworm) Deut.Hemi.Ente ACQM01067921 frag G? RRH peropsin 0 ests
0 1
2 gVLSVIGNSVVLEMFRRYKELLSPSAILLISLALADL 1
2 GLTIFGMSLSCVSSFAGRWLFGKFGCYFHGFAGMLFGLGSIGNLTVISIDRYIITCKRsL 1
2 QWSYRHYYALLAVAWSNALFWSMMPLFGWSSYALEPEGTSCTIDWMNNDNQYISYVSCVTVTCFILPCAVMTYDYLAAYMKMVKAGYTLSEETEKPNND 0
0 MCIALVAAFLLSWFPSATVFLWAAFGNPGNIPLSFTGVADAFTKIPAVFNPVIYVALNPEFRKYFGKTIGCRRKRKKPIAVRLNGSEQNVENTI* 0</font>
<font color="magenta">>PER1_lotGig Lottia gigantea (limpet) Loph.Moll.Gast genomic full G? retinochrome
0 MTAAEFSSFEHSIVGITYMVI 1
2 GISGTLLSLLVALTFIREKGLFKYGRAWLHISLAIANVGVVGAFPFSGSSSFSGR 2
1 WLYGSGMCTFYGFIGMFFGIAAIGNVFALCVERYLVSKKKDS 1
2 VDKVSNQFYWMITALVWINAFFWGIMPALGWTS 2
1 YDIEPSGTSCTIKWQNYDSGYPSFMAMLSLTCFLIPLPVALICLILSGTDKITEDKEEKTYFREDQLRS 0
0 TCTFLLILALIGWGPYCFICIWALFADTTQVSMLAAVIPPLAAKTMVLLYPVAYCQGNKRFKNAFLGMFIFNESPKQQ* 0
>PER1_aplCal Aplysia californica (sea_slug) Loph.Moll.Gast EB338056 17190607 full G? retinochrome from 8 8k contig to traces
0 MNDDGNALDGAGVDPAATAAHVSTALGFTKFEHASVGALYMLF 1
2 CIVGVTLNLLTALTFYKDTKLTKGSQPWLHILLALANVGVVAPSPFPASSSFSGR 2
1 WLYGSTMCQIYAFEGMFIGIAAIGAVIALCIERYIACQRSGA 1
2 NDTQGWFYGWSITLVLGNALFWAIMPLLGWSR 2
1 YSVEHTGTSCSIDWKNPDESFVSYIMTLEVFSFGIPMMSAFFCLISASPRPQPQGGATAAAGSGQEQQGEDTACKGCFSEDQLRL 0
0 LCYVFIGFVLVGWGPFAYLCTLAVFSDARGISMLAAAIPPLACKAMVSAYPLAYAVVSPRFRQSFLALIGGGEKKKE* 0
>PER1_todPac Todarodes pacificus (squid) Loph.Moll.Ceph genomic 2226795 full G? retinochrome retinochrome 1991 seq dubious before GDPAH
0 MFGNPAMTGLHQFTMWEHYFTGSIYLVL 1
2 GCVVFSLCGMCIIFLARQSPKPRRKYAILIHVLITAMAVNGGDPAHASSSIVGR 2
1 WLYGSVGCQLMGFWGFFGGMSHIWMLFAFAMERYMAVCHREF 1
2 YQQMPSVYYSIIVGLMYTFGTFWATMPLLGWAS 2
1 YGLEVHGTSCTINYSVSDESYQSYVFFLAIFSFIFPMVSGWYAISKAWSGLSAIPDAEKEKDKDILSEEQLTA 0
0 LAGAFILISLISWSGFGYVAIYSALTHGGAQLSHLRGHVPPIMSKTGCALFPLLIFLLTARSLPKSDTKKP* 0
>PER2_patYes Patinopecten yessoensis (scallop) Loph.Moll.Biva AB006455 9287291 full Go retinochrome depolarizing scop2 inner retina layer
0 MPFPLNRTDTALVISPSEFRIIGIFISIC 1
2 CIIGVLGNLLIIIVFAKRRSVRRPINFFVLNLAVSDLIVALLGYPMTAASAFSNR 2
1 WIFDNIGCKIYAFLCFNSGVISIMTHAALSFCRYIIICQYGY 1
2 RKKITQTTVLRTLFSIWSFAMFWTLSPLFGWSSYVIEVVPVSCSVNWYGHGLGDVSYTISVIVAVYVFPLSIIVFSYGMILQEKVCKDSRKNGIRAQQRYTPRFIQDIEQRVTF 0
0 ISFLMMAAFMVAWTPYAIMSALAIGSFNVENSFAALPTLFAKASCAYNPFIYAFTNANFRDTVVEIMAPWTTRRVGVSTLPWPQVTYYPRRRTS
AVNTTDIEFPDDNIFIVNSSVNGPTVKREKIVQRNPINVRLGIKIEPRDSRAATENTFTADFSVI* 0</font>
<font color="#CC00FF">>PER_hasAda Hasarius adansoni (spider) Ecdy.Chel.Arac AB525082 19960196 full Go peropsin first ecdysozoan peropsin
0 MDDNMSEIALADDMSTLSTQEPSENVYPYVFPLSTHTIVGTYLIII 1
2 GILGTLGNGLVLVTFLRFRVLVTPTTLLLVNLAVSDLGLILFGFPFSASSSLSAK 2
1 WIFGEGGCQWYAFMGFLFGSAHIGTLALLALDRYLIACRISL 1
2 RGKLTFKRYTQMITVVWTYAFFWALMPLLGWGR 2
1 YGLEPSVTTCTIDWQHNDSSYKSFLIVYFVLGFMVPFAIIAVSYIAIARRVGKKSKERPVVRDLWTNERSVTL 0
0 MAFILIVTFFVAWSPYAVLCLWTIFAEPNTVPPFLTLIPPLFAKSSTVVNPLIYFLSNPKLRTAILSTLSCCNEAPIQNIELPDSPERAANNDAI* 0
>PER_ixoSca Ixodes scapularis (tick) Ecdy.Chel.Arac ABJB010816023 frag Go peropsin mRNAs XM_002409761 XM_002435011 embryonated eggs
1 WLFGATGCQAYAFMGFLFGSAHIGTLTLLALDRYLATCRIGF 1
2 RSKPTFKRYFQLLLLVWLYGLFWAVMPLLGWAR 2
1 YGLEPSFQSCTIDWRHNDSSYKSFTLVYFVLGFLVPACIVLVCYRTSAIHIRAPKPKTVRRDVTDDYWASEEMVTV 0
0 MVALIVVTFFFAWTPYAVLCLWAVFADTKSVPHLLAMVPPLFAKTASTINPFIYFLSNPCIRADVLQLLGCRARSSPHMAISSDAVEEERCCQDQA* 0</font>
<font color ="#CC3366">>NEUR1_homSap Homo sapiens (human) Deut.Euth.Euar NM_181744 14623103 full G? OPN5 neuropsin index sequence
0 MALNHTALPQDERLPHYLRDGDPFASKLSWEADLVAGFYLTII 1
2 GILSTFGNGYVLYMSSRRKKKLRPAEIMTINLAVCDLGIS 1
2 VVGKPFTIISCFCHRWVFGWIGCRWYGWAGFFFGCGSLITMTAVSLDRYLKICYLSY 1
2 GVWLKRKHAYICLAAIWAYASFWTTMPLVGLGDYVPEPFGTSCTLDWWLAQASVGGQVFILNILFFCLLLPTAVIVFSYVKIIAKVKSSSKEVAHFDSRIHSSHVLEMKLTK 0
0 VAMLICAGFLIAWIPYAVVSVWSAFGRPDSIPIQLSVVPTLLAKSAAMYNPIIYQVIDYKFACCQTGGLKATKKKSLEGFR 2
1 LHTVTTVRKSSAVLEIHEEV* 0
>NEUR1_calJac Callithrix jacchus (marmoset) Deut.Euth.Euar genomic full G? OPN5 neuropsin
0 MALNHTSLPQDERLPHYLRDGDPFASKLSWEADLVAGFYLTII 1
2 GILSTFGNGYVLYMSSRRKKKLRPAEIMTINLAVCDLGIS 1
2 VVGKPFTIISCFCHRWVFGWIGCRWYGWAGFFFGCGSLITMTAVSLDRYLKICYLSY 1
2 GVWLKRKHAYICLAAIWAYASFWTTMPLVGLGDYAPEPFGTSCTLDWWLAQASVGGQVFILNILFFCLLLPTAVIVFSYVKIIAKVKSSSKEVAHFDSRIHSSHVLEMKLTK 0
0 VAMLICAGFLIAWIPYAVVSVWSAFGRPDSIPIQLSVVPTLLAKSAAMYNPIIYQVIDYKFACCQTGGLKATKKKSLEDFR 2
1 LHTVTTVRKSSAVLEIHEEV* 0
>NEUR1_musMus Mus musculus (mouse) Deut.Euth.Euar genomic full G? OPN5 neuropsin
0 MALNHTALPQDERLPHYLRDEDPFASKLSWEADLVAGFYLTII 1
2 GILSTFGNGYVLYMSSRRKKKLRPAEIMTINLAVCDLGIS 1
2 VVGKPFTIISCFCHRWVFGWFGCRWYGWAGFFFGCGSLITMTAVSLDRYLKICYLSY 1
2 GVWLKRKHAYICLAVIWAYASFWTTMPLVGLGDYAPEPFGTSCTLDWWLAQASGGGQVFILSILFFCLLLPTAVIVFSYAKIIAKVKSSSKEVAHFDSRIHSSHVLEVKLTK 0
0 VAMLICAGFLIAWIPYAVVSVWSAFGRPDSIPIQLSVVPTLLAKSAAMYNPIIYQVIDYRFACCQAGGLRGTKKKSLEDFR 2
1 LHTVTTVRKSSAVLEIHQEV* 0
>NEUR1_ochPri Ochotona princeps (pika) Deut.Euth.Euar genomic full G? OPN5 neuropsin
0 MALNDTALPQDEHLPHYFRDGDPFASKLSWEADLVAGFYLTII 1
2 GILSTFGNGYVLYMSSRRKKKLRPAEIMTINLAVCDLGIS 1
2 VVGKPFTIISCFCHRWVFGWIGCRLYGWADFFFGCGSLITMTAVSLDRYLK 1
2 GVWLKRRHAYICLAVIWAYASFWTTMPLVGLGDYAPEPFGTSCTLDWWLAQASVGGQVFILNILFFCLLLPTAVIVFSYVKIIAKVKSSSKEVAHFDSRIHGSHVLEMKLTK 0
0 VAMLICAGFLIAWIPYAVVSVWSAFGRPDSIPIQLSVVPTLLAKSAAMYNPIIYQVIDYKFSCCRTGGLKQTKKKSLEDFR 2
1 LHTVTTVRKSSAVLEIHQEv* 0
>NEUR1_canFam Canis familiaris (dog) Deut.Euth.Laur genomic full G? OPN5 neuropsin
0 MALNHTARPQDERLPHYLREGDPFASKLSWEADLVAGFYLTII 1
2 GILSTFGNGYVLYMSSRRKKKLRPAEIMTINLAICDLGIS 1
2 VVGKPFTIISCFCHRWVFGWIGCRWYGWAGFFFGCGSLITMTAVSLDRYLKICYLSY 1
2 GVWLKRKHAYICLAVIWAYASFWTTMPLVGLGDYAPEPFGTSCTLDWWLAQASLGGQIFILNILFFCLLLPTAVIVFSYVKIIAKVKSSSKEVAHFDSRIHSSHVLEMKLTK 0
0 VAMLICAGFLIAWIPYAVVSVWSAFGRPDSIPIQLSVVPTLLAKSAAMYNPIIYQVIDYKFACCQTGRLKATKKKSLEDFR 2
1 LNTVTTVRKSSAVLEIhQEV* 0
>NEUR1_bosTau Bos taurus (cow) Deut.Euth.Laur genomic full G? OPN5 neuropsin
0 MALNHTAPPPDERRPPYLRDGDPFASKLSWEADLVAGFYLTII 1
2 GILSTFGNGYVLYMSSRRKKKLRPAEIMTVNLAICDLGIS 1
2 VVGKPFTIISCFCHRWVFGWIGCRWYGWAGFFFGCGSLITMTAVSLDRYLKICYLSY 1
2 GIWLKRKHAYICLAVIWAYAAFWTTMPLVGLGDYAPEPFGTSCTLDWWLAQASVGGQIFILNILFFCLLLPTAVIVFSYVKIIAKVKSSSKEVAHFDSRIHSSHVLEVKLTK 0
0 VAMLICAGFLIAWIPYAVVSVWSAFGRPDSIPIQLSVVPTLLAKSAAMYNPIIYQVIDYKFACCQTGGLKATKKKSLEDFR 2
1 LHTVTTVRKSSAVLEVHQEv* 0
>NEUR1_loxAfr Loxodonta africana (elephant) Deut.Euth.Afro genomic full G? OPN5 neuropsin
0 MTLNHTAPPQDDRLPQYLQDGDPFTSKLSWEADLVAGFYLTII 1
2 GILSTFGNGYVLYMSCRRKKKLRPAEIMTINLAVCDLGIS 1
2 VVGKPFVIISCFCHRWVFGWIGCRWYGWAGFFFGCGSLITMTAVSLDRYLKICYLSY 1
2 GVWLKRKHAYICLAVIWAYASFWTTMPLVGLGDYAPEPFGTSCTLDWWLAQASVGGQIFILNILFFCLLLPTAVIVFSYVKIIAKVKSSSKEIAHFDSRIHSSHMLEMKLTK 0
0 VAMLICAGFLIAWIPYAVVSVWSAFGRPDSIPIQLSVVPTLLAKSAAMYNPIIYQVIDYKFACCQTGGLRATKKKSLEGFR 2
1 LHTVTTVKKSSAVLEVHQEv* 0
>NEUR1_dasNov Dasypus novemcinctus (armadillo) Deut.Euth.Xena genomic full G? OPN5 neuropsin
0 MALNHTALPQDDRLPHYLRDGDPFASKLSWEADLVAGFYLTII 1
2 gILSTFGNGYVLYMSSKRKKKLRPAEIMTINLAVCDLGIS 1
2 VVGKPFTIISCFCHRWVFGWIGCRWYGWAGFFFGCGSLITMTAVSLDRYLKICYLSY 1
2 GVWLKRKHAYICLAVIWAYASFWTTMPLVGLGDYVPEPFGTSCTLDWWLAQASVGGQVFILNILFFCLLLPTAVIVFSYVKIIAKVKSSSKEVAHFDSRIHSSHVLEMKLTK 0
0 VAMLICAGFLIAWIPYAVVSVWSAFGRPDSIPIQLSVVPTLLAKSAAMYNPIIYQVIDYKFACCQTGGLRATKKKSLEDFR 2
1 LHTVTTVRESSAVLEVHQEV* 0
>NEUR1_monDom Monodelphis domesticus (opossum) Deut.Meta.Dide genomic full G? OPN5 neuropsin
0 MALNHSVSPQDDYIPHYLRDGDPFASKLSWEADLVAGFYLTII 1
2 GVLSTLGNGYVIYMSSKRKKKLRPAEIMTVNLAVCDLGIS 1
2 VVGKPFTIISCFSHRWVFGWVGCRWYGWAGFFFGCGSLITMTAVSLDRYLKICHLSY 1
2 GTWLKRHHAFICLALIWAYATFWATVPFAGVGSYAPEPFGTSCTLDWWLAQASVAGQAFVLSILFFCLLFPTAVIVFSYVKIILKVKSSTKEVAHYDTRIQNSHILEMKLTK 0
0 VAMLICAGFLIAWIPYAVVSVWSAFGQPDSIPVQFSVVPTLLAKSAAMYNPIIYQVIDCKFACCQSGGQKAAKKESLRTYR 2
1 LHTVTTVRRSSAVLEIHQEv* 0
>NEUR1_ornAna Ornithorhynchus anatinus (platypus) Deut.Prot.Mono genomic full G? OPN5 neuropsin
0 MTNYSAPQLGDYLPHYLREGDPFVSKLSWEADLVAGVYLVII 1
2 GVLSTLGNGYVIYMSSRRKKKLRPAEIMTVNLAVCDLGIS 1
2 VVGKPFTIVSCFCHRWVFGWMGCRWYGWAGFFFGCGSLITMTAVSLDRYLKICHLSY 1
2 GTWLKRHHAYICLAIIWAYASFWATMPLVGLGNYAPEPFGTSCTLDWWLAQASVAGQAFILNILFFCLLLPTAVIVFSYVKIIAKVKSSTKEVAHFDSRIQNSHVLEMKLTK 0
0 VAMLICAGFLIAWIPYAVVSVWSAFGQPDSIPIQFSVVPTLLAKSAAMYNPIIYQVIDCRISCCRLGGPKTGKKESLKNSR 2
1 SHSMSTIRKPSAVSGPHQEV* 0
>NEUR1_galGal Gallus gallus (chicken) Deut.Saur.Arch genomic full G? OPN5 neuropsin
0 MASDCNSSSQEEYLPHYMQQEDPFASKLSREADIIAGFYLTVI 1
2 GILSTLGNGYVIFMSSKRKKKLRPAEIMTVNLAVCDLGIS 1
2 VVGKPFSIISFFSHRWIFGWMGCRWYGWAGFFFGCGSLITMTAVSLDRYLKICHLAY 1
2 GTWLKRHHAFICLALIWAYATFWATVPFAGVGSYAPEPFGTSCTLDWWLAQASVAGQAFVLSILFFCLLFPTAVIVFSYVKIILKVKSSTKEVAHYDTRIQNSHILEMKLTK 0
0 VAMLICAGFLIAWIPYAVVSVWSAFGQPDSVPIQFSVVPTLLAKSAAMYNPIIYQVIDCKFACCRSGGPKTLQKKSSLKESR 2
1 MYTISSHRDSAALSGTQLEV* 0
>NEUR1_xenTro Xenopus tropicalis (frog) Deut.Amph.Anur genomic full G? OPN5 neuropsin
0 MAGNSSYREESGYIPHYERDSDPFASKLSREADIFAGVYLMAI 1
2 GILSTLGNGYVIYMACSRKKKLRPAEIMTINLAVCDLGIS 1
2 VTGKPFAIVSCFSHRWVFGWNACRWYGWAGFFFGCGSLITLTVVSLDRYLKICHLRY 1
2 GTWLKRRHAFIALAVIWAYATLWATLPLVGVGNYAPEPFGTTCTLDWWLAQASVKGQIFVLSMLFFCLLFPTMVIVFSYAKIIAKVKSSAKEVAHFDTRNQNNHTLEIKLTK 0
0 VAMLICAGFLIAWFPYAVVSVWSAFGQPDSIPIELSVVPTMMAKSASMYNPIIYQVIDCKPACCKKDKSLQNTTSR 2
1 VYTISTFRKSTTSAR* 0
>NEUR1_danRer Danio rerio (zebrafish) Deut.Acti.Otoc genomic frag G? OPN5 neuropsin
0 MENETSISSGYIPHYLLRGDPFASKLSKEADIVAAFYILVI 1
2 GILSATGNGYVMYMTFKRKTKLKPPEIMTLNLAIFDFGIS 1
2 VSGKPFFIVSSFSHRWLFGWQGCRYYGWAGFFFGCGSLITMTIVSFDRYLKICHLRY 1
2 gTWLKRHHAFLSVVFIWAYAAFWATMPVVGWGNYAPEPFGTSCTLDWWLTQASVSGQSFVMCMLFFCLIFPTVIIVFSYVMIIFKVKSSAKEVSHFDTRNKNNHSLEMKLTK 0
0 VAMLICAGFLIAWIPYAVVSVM
>NEUR1_calMil Callorhinchus milii (elephantfish) Deut.Chon.Holo genomic frag G? OPN5 neuropsin
0 MTAFDNSTALYSGYWLHDSLHGDPFVSKLSWEADIISACYLIVT 1
2 GLLSTLGNGYVIYLSITQKRKLKPPEILITNLAISDFGMS 1
2 VGGQPFLIISCFSHRWIFGWVGCRWHGWAGFFFGCGSLITMTVVSLDRYLKICHLQY 1
2 GSWLQRRHVFMSLAFIWFYAAFWATMPLVGWGNYAPEPFGTSCTLDWWLARVSVSGLIFVLTILFFCLLLPIIIIVFSYIKIIAKVKSSAKEVAHFDSRIQNHHSLEMNLTK 0
>NEUR1_petMar Petromyzon marinus (lamprey) Deut.Agna.Hype genomic frag G? OPN5 neuropsin
0 VAMMICAGFLLAWIPYAVVSVWSAFGAPDSVPVAVSMVPTMFAKSAAMYNPLIYQLLSRRGTGAHCCRCRKARGTLRRPR 2
>NEUR1a_braFlo Branchiostoma floridae (amphioxus) Deut.Ceph.Bran FE548698 frag G? OPN5 neuropsinframeshifted cDNA FE548698 last exons missing
0 MATTPADRLDGLTPAGRGATTAETHADDFASKLSREADIVIGVYLILI 1
2 GTGAILGNGRVLWLSYRCRARLRPVEMFVVSLAVADVGLSLVGHPFAAASSLMGRWSFGSAGCTW 1
2 YGFVVFFLGIASIASMTLMSIMRFMIVYKRYP 1
2 GQYPTRRASCVLVTAAWLYGLFWACAPLA 1
2 GWSQYQPEPYGLSCSVDWGGFSSDAGGSSFIICMLLFCTAVPVVIMVTSYAAIFVIYRQAQKGVVLNLQVNATFGGKRQRTERKLTL 0
0 IALAVCGGFLLAWLPYAVVGLWASVAGVDAVPLALASAAPLFAKSNSLWNPIIYLGMNERFR 2
>NEUR1b_braFlo Branchiostoma floridae (amphioxus) Deut.Ceph.Bran XM_002202511 full G? OPN5 neuropsin from tracesseparate allele
0 MATTPGLPLDGLAPTGRGVTAADTLDDDFASKLSREADIVIGVYLLLI 1
2 GTGSILGNGRVLWLSYRNWAKLRPVELFVVSLAVTDVGISVFGYPFAASSSLLGRWSFGSAGCTW 1
2 YGFTGFFFGLTSIANMALMSIMRFMIVYKGYP 1
2 GPYPSRRATSGLIAAAWLYGLFWACAPLA 1
2 GWSQYHVEPFGLSCTVDWGSFSRDAGGMSFIICLLVFCVAIPVTAIMASYVAISAIYRQAKKSIAGHLQDNSAMCKKRNKLERSITL 0
0 MALAVCGGFLLAWLPYAVVGLWSAVAGVDAVPLALASAAPLFAKSSSLWNPIIYLGMNDRFS 2
1 AELSREHSYLPATGVRTTGPPAEDNQAEGDDVSSPSLLFFRRLFWTSKT 1
2 SNAMRTLVVLTWISTIFPLLLAAPQADPRTTYKVSRWDEAWRPQRFGRSGRGDTKDGWRPQRFGRGRYEQGWRPQRFGRNEGLAGLREVLDGEAFPLLQMTR
TDLHHDLPGIGYTPGTAHGSLRALPLLRLYDRGALQLINGAAKQSSTNPPSLRMIRAAAESLQGFARGGDQQDEEEMFAPPRSTDDWLAEIQRLGLRGRKRRDVS* 0
>NEUR_strPur Strongylocentrotus purpuratus (sea_urchin) Deut.Echi.Eleu XM_001197837 full G? CX694910 CX690664
0 MDVNAKWWTNETLRTRDQFSDDHYTSVLSYEGDIWAGVYLMFI 1
2 SLIAFIGNISVIVISLRKREKLKPIDLLTINLAIADFLICVVSYPLPMISAFRHR 0
0 WSFGKFGCVWYGFTSFLFAVGSMATLMVIALLRYAKLCRENV 1
2 DQYQSRPFVIKVIVAIWGFAFFTTAPPLFGWS 2
1 SYVPEPYHLSCTIDFADTSPSGLSYTYFTTIVVFFMPLMIIVLCYVAIARKMIHHNRRINVGHNAGRMLLEIRLLK 0
0 TACMITMAYTISWTPYAVIAMWVTYIPVNQIPDAFRILPAFCAKTSSVYNPIIYCIFNKSFRQDLSSLICCCACQCYTITINLDINSHAQQQFRRIEERR
DEVGTYKRRPLMICSNPFAWSRDFHETWRQRRIRGIHRNCRNNVRVENINVNFRRDTDMVELNAPTPAEIHRPELNTASTRSGARTKSMATHLPALEEVPSG
APQCSALLHNTPIPRSLQGTPLPYQPQPSTSDLHDEFLNPSVVSRNMCVIVVKPNIEEELSTD* 0
>NEUR2_galGal Gallus gallus (chicken) Deut.Saur.Arch AB368181 18570255 full G? cOpn5L1 syn(-B4GALT6 -NEUR2_galGal -KIAA1012) GenBank 5'UTR error
0 MDPSFANSTFQSKITEAADIVVGTCYMVF 1
2 GICSLCGNSILLYISYKKKHLLKPAEYFIINLAISDLAMTLTLYPLAVTSSLSHR 2
1 WLYGKHICLFYAFCGLFFGICSLSTLTLLSVVCCLKICFPAY 1
2 GNRFRRKHGQILIACAWTYAAIFACSPLAHWGEYGEEPYGTACCIDWQSTNVDVMSMSYTVVLFVLCFILPCGVIVTSYSLILVTVKESRKAVEQHVSGPTRINNVQTITAK 0
0 LSIAVCIGFFAAWSPYAIIAMWAAFGSIDKIPPLAFAIPAVFAKSSTLYNPIIHLLLKPNFRSNIAKDFTVIQQLCVRCCFCVKELQTYRSTFNTGLRTFKGKNESSCNALPIMEG
CSYFPSEKGSHTFECFKSYPNCFQERLSTMGCHLQDCESLENDLQVEVTQGSRNSMKVVEQEEKSTELDNLEITLEAVPVSCTFTDL* 0
>NEUR2_anoCar Anolis carolinensis (lizard) Deut.Saur.Lepi genomic full G?
0 MESYFANTTFHSKITEAADVIVGVFYIVF 1
2 GICSFCGNSILLYVSYKKKNLLKPAEYFMINLAISDLGMTLTLYPLAVTSSLAHR 2
1 WLFGQQVCLFYAFCGVFFGVCSLTTLTLLSIVCCLKICFPVY 1
2 GNRFRPGHGWILIACAWVYAAIFAFSPLAHWGEYGAEPYGTACCIDWRISNMKKTAMSYTTALFVFCYIIPCGIIITSYTLILITVKDSRKAVEQHALGPTRMSSVHTITAK 0
0 LSIAVCIGFFVAWSPYAIIAMWAAFGSIDMIPPLAFAVPAVFAKSSTLYNPAMYLFLKPNFRSTIAKDLTVLHRLCLKSCFCPRGMQNCSYRSALEAPLKSFKGRNESSSNSVQIVGGCS
YFPCEKCHDPFECFKNYPKCCQGRLNVMDHTPRESISVENNMQSKTKHASEKYIKVVIRGEKNTDIDNLEITLEHIPTDIKFANL* 0
>NEUR2_xenTro Xenopus tropicalis (frog) Deut.Amph.Anur genomic full G? abundant transcripts
0 MGNKSDASAFYSSISETDDIVLGVLYSVF 1
2 GLLSLSGNSMLLLVAYRKRSILKPAEFFIVNLSISDLGMTGTLFPLAIPSLFAHR 2
1 WLFDKVTCNYYAFCGMLFGLCSLTNLTVLSSVCCLKVCYPAY 1
2 GNKFSTAHSRILLLGIWAYAGLFATAPLADWGKYGPEPYGTACCLDWEASYRERKALSYTISLFVFCYLIPSSLIFISYTLIFVTVKGARRAVQQHLSPQAKGSSIHSLIIK 0
0 LSIAVCIGFLIAWTPYAIVAMMAAFGDPTKIPSLVFALAAAFAKSSTIYNPVVYLLLKPNFLNVVTKDLTLFQTMCAVVCGWCRTPAVKTPCPHKD
LKTTSKPPSSFKKSQGVCRNCVDTFECFRNYPRCCSVGNVDAAQPMAASLVRIPPANGAPQQTVQLVVSSSRTRSGVETVEVSTEAPMSDFIKDFI* 0
>NEUR2_danRer Danio rerio (zebrafish) Deut.Acti.Otoc genomic full G? acquired new intron
0 MGNVSKTALFMSTISRQHDILMGSLYSVF 1
2 FVLSLLGNGMLLFVAYRKRSSLKPAEFFVVNLSVSDLGMTLSLFPLAIPSALAHR 2
1 WLFGEITCLCYAVCGVLFGLCSLTNLTALSSVCCLKVCFPNY 1
2 GNKFSSSHACVMVIGVWCYASVFAVGPLVHWGSFGPEPYGTACCINW 2
1 YTPSHDALAMSYIISLFIFCYVVPCTIIILSYTFILVTVRGSQQAVQQHVSPQTKVTNAHALIVK 0
0 LSVAVCIGFLTAWSPYAIVAMWAAFSANEQVPPTAFALAAIMAKSSTIYNPMVYLLFKPNFRKSLSQDTQMFRHRICLSHSKASPSPGMKDQERQS
SQQCNNKDGSISTPFSSGQAESYGACHVYAEAGPHYQQISRQITARVLEGSVQSEIPVKQLTEKMQNDLL* 0
>NEUR2_calMil Callorhinchus milii (elephantfish) Deut.Chon.Holo genomic frag G? novel paralog of neuropsin
0 1
2 GILSLVGNSVLLFVAYRKRQILKPAEYFVANLAVSDISMTVTLLPLAISSNFSHR 2
1 WLFVSKpCMYYGFCSMLFGICSLTNLTVLSTVCCMKVCFPAY 1
2 0
0 MSVVMIVMFLLAWSPYSIVCLWASFGNPKLIPPAMAIIAPLFAKSSTFYNPCIYVISYTMTVIAVNFVVPLSVMFFCYYNV
>NEUR3_galGal Gallus gallus (chicken) Deut.Saur.Arch AB368183 18570255 full G? cOpn5L2 testis exon 2 fused exon 3 rel NEUR1/2
0 MEEQYISKLHPVVDYGAGVFLLII 1
2 AILTILGNSAVLATAVKRSSLLKSPELLTVNLAVADIGMAISMYPLAIASAWNHAWLGGDASCIYYALMGFLFGVCSMMTLCAMAVIRFLVTNSSKSN 1
2 SNKISKNTVHILITFIWLYSLLWAILPLVGWGYYGPEPFGISCTIAWSKFHSSSNGFSFILSMFLLCTVLPALTIVACYLGIAWKVHKAYQEIQNINRIPHAAKLEKKLTL 0
0 MAVLISVGFLSAWTPYAAASFWSIFNSSDSLQPIVTLLPCLFAKSSTAYNPFIYYIFSKTFRHEIKQLQCCWGWRVHFFSADNSAENSVSMMWSGRDNIRLSPTAKVESQGAARH* 0
>NEUR3_taeGut Taeniopygia guttata (finch) Deut.Saur.Arch ABQF01025032 full G?
0 MEEQYISKLHPVVDYGAGVFLLII 1
2 AILTILGNSAVLATAVKRSSLLKPPELLTVNLAVADIGMALSMYPLAIASAWSHAWLGGDASCVYYALMGFLLGVCSMMTLCAMAVIRFLVTNSPKSN 1
2 sNKITKNTVCILIAFIWLYSLLWAILPLVGWGYYGPEPFGISCTIAWSKFHNSSNGFSFILSMFLLCTVLPALTIVACYLGIAWKVHKAYQEIQNIDRIPNAAKLEKKLTL 0
0 MAVLISVGFLSSWTPYAATSFWSIFNSSHSLQPVVTLLPCLFAKSSTAYNPFIYYVFSKTFRCEVKRLQCCCAWRVHYFSSDNSVENPLSTMWSGRDNIRLSAAPQVQNPGAAAP* 0
>NEUR3_anoCar Anolis carolinensis (lizard) Deut.Saur.Lepi AAWZ01001057 full G?
0 MEEHYISKVHPVWDYGMGVFLLII 1
2 AILTILGNSMVLAVAVKRSSCLRSPELLTVNLAATDLGMGLSMYPLAIASAWNHAWLGGEATCIYYALMGFLFGVSSIMTLSAMAVIRFLVTFSSKPA 1
2 GHKINRKVMHICIMLIWAYAVLWAILPLLGWGHYGPEPFGTSCTIAWGQFHNSQKGFAFILSMFILCTFLPAITIIMCYLGIAWKFHKTHQEMQNLNRISSAAKLEKKLIL 0
0 VAVLISVGFLGAWTPYAIVSFWSVFHSSESIPYIVTLLPCLFAKSSTAYNPFIYYTFSKTFRHEVKHLRCYSGQRAQENMKNSINSNVSFMWHGGGNICLSTRQIEMREIPNQ* 0
>NEUR3_xenTro Xenopus tropicalis (frog) Deut.Amph.Anur genomic full G? cdna ovary embryo
0 MEERYLSKLHPLVDFGSGVFLLLV 1
2 AILTVLGNCAVLATAVKCSSHLKAPDLLSINLAVADLGMAISMYPLAIASAWNHAWLGGDASCLYYALMGFFFGVSSMMTLTVMAIIRYRVTSSFKYS 1
2 GCTIEKKAVCILIMCIWLYALLWAVLPLLGWGRYGPEPFGTSCTIAWGDFHHSSNGFSFIISMFILCTISPAVTIVVCYSGIAWKLHKAYQEIKNQDKIPNSTKVEKKLTL 0
0 LAILVSFGFLISWTPYAAVSFWSLFHSSKYIPPVVSLLPCLFAKSSTAFNPMIYYAFSKTFRRKVKHLKCCCGWRVHFLQSENSVENPRVSVIWTGKENVMVSSVPKLMKGVPGTPTGTQ* 0
>NEUR3a_danRer Danio rerio (zebrafish) Deut.Acti.Otoc genomic full G?
0 MDRYTSKLSPAVDYSAGTFLLVI 1
2 AILSILGNAAVLLTAAWRHSVLKAPELLTVNLAVTDIGMALSMYPLSIASAFNHAWIGGDPSCLYYGLMGMIFSVASIMTLAVMGLVRYLVTGNPPK 1
2 SGSKFRRKTISILIGVIWMYSLLWAVFPILGWGGYGPEPFGLACSVDWMGYQHSLNRSSFIMALAILCTLMPCVVILFSYSGIAWKLHKAYQSIQSNDNLPNSGAVERKVTL 0
0 MGILISTGFIVSWAPYVFVSLWTMFRSEGEDSVVPIVSLLPCLFAKCSTVYNPLVYYVFRKSFRREIHQIRICCFQGCWDAVSKMTRGDGPEETSGTHETDNI* 0
>NEUR3b_danRer Danio rerio (zebrafish) Deut.Acti.Otoc genomic full G?
0 MDIYSSKLSSAVDYGIGAFLLLI 1
2 TILSILGNLMVLVMAYKRSNHMKPPELLSVNLAVTDLGAAVTMYPLAVASAWNHHWIGGDVSCVYYGLMGFLFGAASMMTLTIMAIVRFIVSLTLQSP 1
2 KEKISKRNAKILVATTWLYALLWAIFPLIGWGKYGPEPFGLSCTLDWRDMKEHSQSFVITIFLMNLILPAIIIVSCYCGIALRLYVTYKSMDDSNHVPNMIKMQRRLMV 0
0 IAVLISIGFVGCWAPYGIVSLWSIYRPGDSIPAEVSMLPCLFAKTSTVYNPFIYYIFSKTFKREVNQLSRFCGRSNICRPTDAKNRPENTIYLVCDVNKSKPGVEDLSLARSKENETQMLPNQDLHE* 0
>NEUR3a_tetNig Tetraodon nigroviridis (pufferfish) Deut.Acti.Perc genomic full G?
0 MDDKYMSKLSPPVDLWAGIYLVVI 1
2 ALLSVLGNASVLFSASRRLTPLKAPELLTVNLAVTDIGMALSMYPLSIASAFNHAWMGGDTACLYYGLMGMIFSITSIMTLAVMGMIRYLVTGSPPR 1
2 SGVQFQKKTICVVICAIWLYACLWAAFPLLGWGSYGPEPFGTACSIDWTGYGDSLNNATFIVAMSVLCTFLPCLVIFFTYFGIAWKLHKAYKSIKSSDFQYASVERRITL 0
0 IAVLISVGFLGSWAPYGLVSLWSILKDSSSIPPQVSLLPCLFAKSSTVYNPVIYYIFSQSFKLEVQQLFLCC* 0
>NEUR3_petMar Petromyzon marinus (lamprey) Deut.Agna.Hype genomic frag G? new exon
0 MAEQGEDDQFRSKLSPTADIAAGTFLLAV 1
2 AVLSLAGNGAVLGVAARRWAKLKAPELLSVNLALTDLGIAASIYPLAVASAWNHRWLGGQPVCTYYAFAGFFFGTASMGTLTAMAGVRYKGTSTQVH 1
2 VKQITKRAMLAVIVAVWAYALLWSCLPLLGWGR 2 1 YGVEPFGVSCTLAWAELQLTPGGVAFLYAMFVLCLLLPAIAIGLCYAGIVCKLRRAYREGRSKRRTPTARHVESRLTK 0
>NEUR4_ornAna Ornithorhynchus anatinus (platypus) Deut.Prot.Mono XM_001508128 full G?
0 MSLSHSLQVPWRNNLTFLNKEAQVSEQGETIIGIYLLAL 1
2 GWMSWFGNSMVIFILHRQRGILNPTDYLTFNLAVSDASVSVFGYSRGIIEIFNVFRDDGFLITSIWTCQ 0
0 VDGFLTLLFGLASINTLAMISVTRYIKGCHPHR 1
2 GHFINTANISVALILIWVSALFWSAGPVLGWGSYT 1
2 DRMYGTCEIDWAEANFSSICKSYIISIFFCCFFLPVSIMFFSYVSIIKMVKSSHTLAGADDPTDRQRRLDRDVTR 0
0 VSVVICTAFIVAWSPYAVISMWSAFGHSVPNLTSVLASLFAKSASFYNPIIYFGMNSKFRKDILVLLPCAKESKEPVKLKKFKNLRQKQGFTLQKPEKAHVLQVPDSGPMSLINTPPLGNRNSFDLACDNSDFECVRL* 0
>NEUR4_galGal Gallus gallus (chicken) Deut.Saur.Arch genomic full G? genome gappy
0 MSLQLSPQAPWRNNNISFLSREAAVTEQGETIIGFYLLAL 1
2 GWMSWFGNSVVIFVLYKQRHLLQPTDYLTFNLAVSDASISVFGYSRGIIEIFNVFRDDGFIITSIWTCQ 0
0 VDGFLTLLFGLASINTLTVISVTRYIKGCHPER 1
2 AHCISNSSMTVAMVLIWIAAFFWSAAPLLGWGSYT 1
2 DRMYGTCEIDWAKANFSTIYKSYIISIFICCFFLPVTVMVFSYVSIINTVKLSHALTGLSDPTERQRRMERDVTR 0
0 IVICTAFIIAWSPYAVLLLWSAYGHPVPNLPLYLSSLFAKSASFYNPIIYFGMSSKFRRDIFILFHCAKEVKDPVKLKRFKNLKQKQEPSQKEEKYAAEMHPAPSPDSGVGSPTNTPPPANREEYFGILDTPSNSPDIECDRL* 0
>NEUR4_taeGut Taeniopygia guttata (finch) Deut.Saur.Arch genomic full G?
0 MSVQFSAQAPWRNNNISFLTREAAVTEQGETIIGFYLLAL 1
2 GWLSWFGNSIVIFVLYKQRHVLQPTDYLTFNLAVSDASISVFGYSRGIIEIFNVFRDDGFIITSIWTCQ 0
0 VDGFLTLLFGLASINTLTVISVTRYIKGCHPER 1
2 GHCISNSSMSVALVLIWVAAFFWSAAPLLGWGSYT 1
2 DRMYGTCEIDWAKASFSTIYKSYIVSIFICCFFLPVTVMVFSYVSIINTVKLSHT LTGLGDPTDRQRRIERDVTR 0
0 VSLCTAFIIAWSPYAVISIWSAYGHPVPNLTSILASLFAKSASFYNPIIYFGMSSKFRRDIFIFHCAKELKDPVKLKRFKNLKPKQPQPSQKEEKYAPEMHPAPSPDSGVGSPTNSPPPANREVYFGILDTPSNNPNIECDRL* 0
>NEUR4_anocar Anolis carolinensis (lizard) Deut.Saur.Lepi genomic full G?
0 MSLQVSPQAPWRNNNVTFSNKEVPVSEQGETIIGFYLLAL 1
2 GWMSWFGNSIVIFVLYRQRAGLQPTDYLTFNLAVSDASVSVFGYSRGIIEIFNVFRDDGFLITSIWTCQ 0
0 VDGFLTLLFGLASINTLTVISVTRYIKGCHPDR 1
2 GKCISNSSISVALFLIWIAAFFWSVAPVLGWGSYr 1
2 DRMYGTCEIDWAKANFSTIYKSYIVSIFICCFFLPVSVMVFSYVSIINTVKSSHALSGVGDPTERQRRMERSVTR 0
0 VSLVVICTAFITAWSPYAVISMWSAYGYTVPNLTSILASLFAKSASFYNPIIYFGMSSKFRKDIFVLLHCAKEIKDPVKLKRFKNLKQKQEVSPSQREEKYAADVQPALSPDSGVGRSNTPPPVNREVYFGAFDTFSNNPDVECDRL* 0
>NEUR4_xenTro Xenopus tropicalis (frog) Deut.Amph.Anur genomic full G?
0 MSLQFPRPAPWRNNNLTLLQKENPLTEQGETIIGIYLLAL 1
2 GWLSWFGNSIVIFVLYKQRANLLPTDYLTFNLAVSDASTSVFGYSRGIIEIFNVFRDDGFLITSIWTCQ 0
0 VDGFLTLLFGLASINTLTLISVTRYIKGCHPQR 1
2 ANCISNGSITISLALIWIAALFWSVAPLLGWGSYR 1
2 DRMYGTCEIDWTKASFSTIYKSYIISIFICCFFLPVMVMVFCYVSIINTVKSSRALTSEGDLSERQRKMERDVTR 0
0 VSVVICTAFIVAWSPYAVISMWSACGYYVPSLTSILAALFAKSASFYNPLIYFGMSSKFRKDLCVVLPCAKAQKDPVKLKRYKDKKQGSAPRAREQTEIEQPVQLQPAPSQDSGVGSPSNTPPLRTKDVHIVDIDLVSDNPSYECDRL* 0
>NEUR4_danRer Danio rerio (zebrafish) Deut.Acti.Otoc genomic full G?
0 MSAQNPLQVVNIPWRNNNFSLMSRDPPLSDQGETIIGVYLLIL 1
2 GWLSWFGNSIVIFVLFRQRSTLQPTDYLTLNLAVSDASISVFGYSRGILEIFNIFKDSGYIISSVWTCQ 0
0 VDGFFTLVFGLSSINTLTVISITRFIKGCHPHK 1
2 AHCITNSTVAVCVVFIWIGAFFWSAAPVLGWGSYT 1
2 DRGYGTCEIDWVKANYSTIHKSYIISIFIFCFLVPVLLMLFCYISIINTVKRGNAMNADGDLSDRQRKIERDVTI 0
0 VSIVICTAFILAWSPYAVVSMWSAWGFHVPNLTSIFTRLFAKSASFYNPLIYFGLSSKFRKDVSVLLPCGREGRDPVRLKRFKRLRGRAEPPGAPAHTPHPQIALKNYNNHSKPHAGPAHCTGHAPSPDSGVGSHHETPPPQPRPQLFFIDVPEPEAESECVRL* 0
>NEUR4_tetNig Tetraodon nigroviridis (pufferfish) Deut.Acti.Perc genomic full G?
0 MEPSRPWRNSSVLGGGAEPPLSEQGETIIGVYLLLL 1
2 GWLSWFGNTVVLFVLVRQRSSLQPTDLLTFNLAVSDASISVFGYSRGIIQIFNVFQDSGFIISSIWTCE 0
0 VDGFLTLIFGLSSINTLTVISITRYIKGCQPSR 1
2 AALISRSSVSVCLLLIWTTAGFWSGAPLLGWGSYT 1
2 DRGYGTCEIDWSKAASSGVYRSYIISIFIFCFFIPVFIMLFCYISIINTVKRGNALAADGHLSHRQRTMERDVTV 0
0 ISVVICTAFIMAWSPYAVVSMWSAWGFHVPSTTSIVTRLFAKSASFYNPLIYFGMSSKFRKDVSLILPCAKERREVVLLQRFKNIKPKAAAAPPPPPLPVYRPKEKNEDEPKLSVHDNDSGVNSPPETPPSDAQEVFPVDPPSQIETSEYWSDRL* 0
>NEUR4_gasAcu Gasterosteus aculeatus (stickleback) Deut.Acti.Perc genomic frag G?
0 PVKVVNIPWRNNNLSNLNTDPPLSEQGETFIGVYLLVL 1
2 GWLSWFGNSLVMFVLYRQRASLQSTDFLTLNLAISDASISIFGYSRGILEIFNIFNDDGYLINWIWTCQ 0
0 VDGFFTLLFGLASINTLTVISVTRYIKGCHPNK 1
2 AYCISTNTIAVSLICIWTGAVFWSVAPLLGWGSFT 1
2 DRGYGTCEVDWSKANYSTIHKSYIISILIFCFFIPVMIMLFSYVSIINTVKSTNAMSADGFLSTRQRKVERDVTRV 0
0 ISIVICTAFITAWSPYAVVSMWSAWGFHVPSTTSIITRLFAKSASFYNPLIYFGMSSKFRKDVSVLVPCTRERREVVHLQHFKNIKPKAEAPPTPASLPVQKLGAKYAVPNPDADSGVNNPPQRPATDPQGDLNIDLPSHIETSEYWCDRL* 0
>NEUR4_calMil Callorhinchus milii (elephantfish) Deut.Chon.Holo genomic frag G?
0 MGCSLGWKVLLWFLHGILICPRPWRNHNSTFQPKEHPISEQGETIIGVYLLIL 1
2 GWLSWFGNSIVIFILYRQRLSLQPPDYLTLNLAVSDASISIFGYSRGIIEIFNVFRDDGFLITSIWTCQ 0
0 1
2 AVSISAGSIAASLVLIWIAAIFWSGAPLFNWGSYT 1
2 DRMYGTCEIDWSRASFSTIYKSYIISIFICCFFLPVFVMLFSYISIINTVKSSHAFAGNADLSDRQRRMEKDVTR 0
0 VSMVICTAFIIAWSPYAVISMWSASGYTVPQLTGIFASLFAKSASFYNPMIYFGLNSKFRKDIYILLPCVKEPKESVKLKRFKHLRHRPEQQQANKDRYAEELQQVASPDSGMGSPSKSPPLHNKDVFFVLWLRGLKK</font>
<font color ="green">>TMT_triCys Tripedalia cystophora (box_jelly) Cnid.Cubo.Cary EU310498 18577593 full G? c-opsin-like Schiff lysine mRNA with predicted introns
0 MADHGRNTTSNDTNPISKIPLDDFDPQRFYNFYTFMGSFIAGSACCSFLLNGLVIAVLIKYIRTITNTNIIVLSMSCANILIPLLGSPLSATSSLMRKWQFGNGGCTWYGFINTLS 1
2 GISGIYHLTFLSFERFITIVLPLKRDTILSTKNIYIGLGILWVAAIGVAGAPVFGWCEYIKE 1
2 GVRTSCSVAWSSKENMNVFSYNLFMIFTVFLLPMLVIIYCNYRFIKEVSIMSTRA 0
0 RGLQGGDSEMTASASKAEKQLTIMVITMIIAFNIAWLPYTVVSMVFLTGYGDVVGPMGASVPSVFAKTSVIYNPVIYCLLNRS 0
0 FRKMLCGNSVEPE* 0
>CUBOP_carRas Carybdea rastonii (sea_wasp) Cnid.Cubo.Cary AB435549 18832159 full G? cubop
MGANITEILSGFLACVVFLSISLNMIVLITFYRLRHKLAFKDALMASMAFSDVVQAIVGYPLEVFTVVDGKWTFGMELCQVAGFFITALGQVSIAHLTALAL
DRYFTVCRPFVATAIHGSMRNAGMVIFVCWFYASFWAVLPLVGWSNYDVEGDGMRCSINWADDSPKSYSYRVCLFVFIYLIPVLLMVATYVLVQGEMKNMRGRAAQLFGSESEAAL
KNIKAEKRHTRLVFVMILSFIVAWTPYTFVAMWVSFFTKQLGPIPLYVDTLAAMLAKSSAMFNPIIYCFLHKQFRRAVLRGVCGRIVGGNAIAPSSTAVEPGQTLASGTAES*
>ENCa_nemVec Nematostella vectensis (anemone) Cnid.Anth.Hexa genomic full G? Schiff lysine no cdna complete 1 exon
0 MIDNALGRHEANIVLGYYIAIFVIGFVTNTIVVIIFISSQRLHTTPNLILFSMSVCDWLMATMAKSVGIYGNARYWPTVGKVTCDYYAFATSAIGYASILHLAALAVEKRMAVVSPMTNSFNGRRMLVIIATLWGFAILW
AVFPLIGWSSYGPEPGYVSCSITWYTTDHNNVSYIICVSVLFFLIPIVTMTFCFASIYHTIRNLSHEATARWGSDARATQETIRAKAKTAKMAFLMVMCFLFAWTPYAVVSLWTTFGDTHRIPALLGVLPSLFAKLSSCY
NPIIYFFMYTKFRCAGKALLYQEHH* 0
>ENCb_nemVec Nematostella vectensis (anemone) Cnid.Anth.Hexa genomic full G? Schiff lysine NC-extended 1 exon
0 MSNEALRRHEANIVLGYYIAIFVIGFVTNTIVVITFIFSKRLHTTPNLILFSMSVCDWLMAAMAKSVGIYGNARYWPTVGKVTCDYYAFATSAIGYASILHLAALAVEKRMAVASP
MTNSLNERRMLVIIATLWGFAILWAVFPLIGWSSYGPEPGYVSCSITWYTTDHNNVSYIICISVLFFFVPIVTMTFSFASIYKAIRNISHEAIARWGSHARATQETIKAKAKTAKMAF
LMVMCFLFAWTPYAVVSLWTTFGGTHRNPALLGVLPSLFAKLSSCYNPIIYFFMYTKFRRAAKLLFIKKVIRPTEAERSRVLSGIRTRAASTFAVKLTVHAEKGQQIAPNITPQGAVKGPVESIEDNLQKIETITPCTSV* 0
>ENCc_nemVec Nematostella vectensis (anemone) Cnid.Anth.Hexa genomic full G? Schiff lysine C-extended 1 exo
0 MELFTSYHAITVMYSLLAAGAFVLNGIVLIIFLATRSLRTIPNMILLSMAWADWLMACLADAVGAYANANNWPSMVGGLCVYYGFITTALGLTSMIHLTALSVERFVTVTIPMTRPITETQMLLVVTFLWAFSFLWAIFP
LVGWSSYGPEPGYAACSIAWYRQDLNNMSYILCLFMFFFFLPIVIMIACFSSIYFTVRKLTRDSMRRWGASSDSTQQTLAAERKTAWMSFIMVLAFLFAWVPYAVVSLYASFGGVTTIPKLMSTLPAMLAKTSACYNPII
YFFMYSKFRKAFQRFFFKNVITPSQTGGSSTINSASVIPTSFPRASYAVRSSSVLPSSTASHSFRSRE* 0
>ENC_aneVir Anemonia viridis (anemone) Cnid.Anth.Hexa FK729339 19627569 frag G? symbiotic
KDAVARWGNKSPPTQQTMQAQKKTIRMSLVMVFAYLLAWTPYALTSLYSSFIASDITPLLSVMPALFAKLSSCYNPIIYFFMYSKFR
KAAKKMIRRNLVGHDSNSGQGVSNTFATSFPRPISFLRYKRSAVAPLSDIPQVSSVDLPQVGRENDVTVQQDKASEINT* 0
>MEL1_acrDig Acropora digitifera (stony_coral) BACK01045931
METASGVPIVIEASVHHTISFLYFLLALFSFSLNSVVILTFLLDRSLLFPANLIILSIAISDWLMSVVPNIMGGVANASNDLPFTDWSCTVFAFVATLLG
LSNMLHHAAFALDRYMVITRPMRANHSMKRILAVIAFLWCFALTWSLFPLVGWSAYVREAGDIACSVNWQSDNPSDTSYMVCLFFFFYFVPLAVIVYCYA
FMIKSVRFMTKNAQKIWGVRSAAALETVQATWKMAKIGLIMVVGFFVAWTPYAVVSFIIAFDLVKDIPTVAEIVPSMFAKTASVYNPIIYFFSFAYCKNQ
SVNKCINQSTVQSKNFKLS*
>MEL2_acrDig Acropora digitifera (stony_coral) BACK01017283
MPGFQNKSEEPQPTEGISSQDRFIVASFYALLAVTALGLNTPVLITFMKDRKLRVLSNRIILSITIGDWLHAFLAYPVAVFANASHDSQGLTGVVCSWYG
FITVFLSFGIMLHHATFAVERAIVIQFATTSLTNAKTINFMVASLWVFALLWSSFPLFGWSAYVPHVVLCSLDWQSRDLRDVVFVYCIFFVFFLVPIVVM
VTSYYKIFQTVKKMTQNARDLWGEKAAPTREAFESQKKTARMACVMSFCFLFAWTPYAAVSLYVFLWKPQSMAPSISIVPALFAKTSACFNPVIYFLLFR
KFRESLKQTMCGFFMDPKTGTNETNKNKRHVLKNTESKCACVKINNLSPRDPCNLHQRSDCRSVGNSKSHITVD*
>ENC1_acrDig Acropora digitifera (stony_coral) BACK01046894
MLTFACGSTHIYNMSAVFYGFLAAGTVFLNVIVILTFFKVRALLIPASFPILSLAMADVFLASAVMPLGIASCASGHWIFGAVGCNWYAFMHTTVGLSSI
LHHAILALERCLTIFEPMKKHFDRHTMTRTLAFLWTLVSLWSLCPILGWSAYVPEGTGTICSIEWHSKNSLDVIFVVSTFVFFCFVPFVFIAVCYTAIAF
HLRKVSKTAKRTWGKNSQITKDGVIVKRKAVTHGAIMVTTVMITWLPYSMVAFYTLLGFEKVKLSALAYAITAMFAKTSTLVNPIICFFWYRRFREGTKK
LCNRIMDFILRKHRRASNTSHSSKTVWYDGKTIVFRRSVVDSCSTRTQNDRGRSS*
>ENC2_acrDig Acropora digitifera (stony_coral) BACK01016849 11738 bp INV 28-JUL-2011 DOI:10.1038/nature10249
MTALIYSVFAIIAAVICVLGVPLNGLVCWVFYNNRELLNAPNIFIASVAFSDFLYCISCLPLLVISNAYGKWIYGPIGCKATAFIATWSGLTSLMNLSVA
SYERYSTLAFLCTKNRTFAKRTATCYSAAMWLYALFWSLMPLCGWSGFELEGIGTSCSVRWKSKNMLDMSYNLCLIIACYVLPVSVLVTSYYKCYREIAK
STWRAKSTWGRQSPFTKRTFVMERKMMALFGVMTVAFLVAWTPYAVVSLISMIGGPDVISDVTASIPAYFAKSSSCYNPVIYVFLYKRLRRQMRFAVRRD
NCSSSRKGTSSDSTMAHHSETKRLRSTIELTDNYSTRNRPENI*
                   
>ENC3_acrDig Acropora digitifera (stony_coral) BACK01015014 possibly N-incomplete
MVAPHFAGFAIAASLFGSCGIVLNFTVCLTYILNRRLLDASNIFILNISAGDFLYSITALPMLVTSNALGKWSFGEGGCVAYGFLTTFFALGAMMNLAGA
AYERYVTMCKLYESGECQFSRRKAAFLCSVLWTYALIWSIAPIFGWSSYKQEGIGTSCSTDWKSRDVKSLSYGVVLIITCFVVPVAVILYCHIEAYKVTR
KLGKQAQQNWGSHTRATRETLKAQKKMGEIAVVITVGFVVAWTPYTVASVIGMYDPNLVSDVGASIPAYFAKSSSCYNPFIYLFMYKKLRIGMVRLLCCM
KKQVYPSSSGLTRDPTCQEIPMVVPVNNPS*
>ENC4_acrDig Acropora digitifera (stony_coral) BACK01020962 possibly N-incomplete
MTKTAAWSTVFLIIEFVVCLLGIFFNCLVISIIFKNANRLAAPGFLVLSMALSDVLSCSVAVPFSIVAHFQKKWPFGMAGCEAHAFMVFLFALVSITHLA
AISAGKYLTISRSLTRESYFDRRQVLLVVIACWLYSLAFSVAPLVGWSRYGLEGTNATCSIKWDSSEPSDKAYFGVVFIACFFLPMGVITLCYYKIHKVS
KRIVENIQGQSIATSAMSRTHALVKKHRRSAMYFLAIVAAFMLAWSPYAIVSLIVVLSGTMDPIATSACSVFAKTSFLVNPFLYAIFSRSFRRRLALVFP
MPRQNRQEGRQERNCNALPPSQSQPFVL*
>ENC5_acrDig Acropora digitifera (stony_coral) BACK01011015
MDQIKIWKMLFVVIKFIVSIFGGFFNGLVVLTIRKNLRRLPSSSYLILSIAFSDFIASVVAIPFSIVIHFVGSWPLRLCRAHAFMVFFLGIVTITHLTCF
AVEKYLTITRSLSKLSFFSKKQTLVVVMACWFYSLCFSLAPLLGWASYGLEGSNDTCSIKWDSSLAKDHIYFILVFLACYLLPIVLITSSYFKILRISKR
ILKATPRVGGIGETMAQALMRKHRRGALYFLSVIAVFLMSWTPYAIISVLVIFKGVNLFPLALSACGVFAKMSFMLNPIMYFAFSHNFRLLVKRTFCICD
RLDSNSEGKKR*
>CNOP1_acrDig Acropora digitifera (stony_coral) BACK01019215 tandem fragment last exon at beginning of contig
1 LLRRDVVTEDSRIKLRRRHWQMKLLRLTAVAITAFMLSWSPYSLVSLTSIFRGNSVLSTGEAEVPALMAKASVIYNPIVYTVMNRRFRRTLRHIVSCMTCRLLSFVWPTMHGEKQETKKRVTSTMTVTSSTPAPEGNFPEILVSLHQVPF*
>CNOP2_acrDig Acropora digitifera (stony_coral) BACK01019215 MEL
0 MQFSREEDPPSGFNWNNAWFIAYGVVMIAVLSIGFLGNTMTVLILRKHEHASKSLTPLMINLAIASLIIIVLGYPLVISLVVRGSHVTKEDPTCRWSAFINGTV 1
2 GISSIATLTEMSLVINYSLHRMNPNVRLTKRNMALLIAGAWLYGLVSMFPPLVGWNRFVPGAVRISCGPDWTDKSASGVSYNLVLVVLGFFLPLCVMIKAYYEIYRS 2
1 LLRSREMLISANGSFQLRQKLYIKKLVRMTVLAIAAFMLSWAPYCFVSIVAIFKGSHIITSGEAEIPELMAKASVIYNPVVYLITNSSYRASFWKVISCQKQTMIVHVRENLMPNGPSRRTLRSRRMAVLLKPLNEVSVYNGGYVVAMGFASVRDL* 0
>CNOP3_acrDig Acropora digitifera (stony_coral) BACK01018578 TMT
0 MLESSNQSAEETILISKASYYAYGVVMFFILTVGFLGNVMTLLVLFQHEHRKKAMTPYMVNIALADIFIILFGYPVAMRANLRGKILESSHCSWGGFVNGAV
GISSIFTLTEMSFVSYHGLRQVNRSSRFSPFQVVCSVAVAWLYGVLCMLPPFLGWNRFVVSASRISCCPDWSGKSISDAAYNLLLVFFGFVAPLTAMTVCYYKIYR 2
1 SLVHHAVVPGNLPQIQLRRRQSELKVAKVTAMNVIAFLLSWAPYCCVSLAAVFTKQFVLVDWEAEIPELLAKASVIYGPIIYSTMHSRFQATLFRILHCRRRVILAPQFITDATRNNCSARMATDRTQGTSHIDQRFLQLPLQAMKRRVAVSYGGTAICKRESSAFVSG* 0
>CNOP4_acrDig Acropora digitifera (stony_coral) BACK01002540 TMT
0 MTTRSDDNPNSARRPQQIAFIVYVVIMTVILIVGFLGNLFTIIVLRCPEHKKKIITPLMMNLAFADIIIIVFGYPVVMASNFTEHNVLTNPMLCVWSGFINGSV
GIASIANLTMMSLVMFKSLNKVGTVKKIPWKKMLAMILFTWVYGVLSMFPPLVGWNKFVPGASGISCCPDWSPDTKAAVGYNILLVFVGFVLPLTIIIFCYYRMYR 2
1 FIHTQQPVTGNASIQASRRRSEIKIVRMIALAIAAFVLSWSPYCFVSIAGTIRGSSLLTAGEAEVPDLLAKASVIYNPIVYTVMNDRFRGTLLRVIPCRRRWFNGDINPTVSVSAPNSQDGNSHNFRERPQSVKGNSTV* 0
>CNOP5_acrDig Acropora digitifera (stony_coral) BACK01002513 and near identical BACK01007224
0 MTTSFRSNMTDEWGTHKYFSAGYIAYGVVMFCILSLGFVGNTLTVLVLTKREHRWRGVTPLMINLAVADLLIIIFGYPTQVHANFTGDGVPNDSHCNYRGFIN
GIVGITCIFTLTEMGVVSYSGLRRVSGNVRLSSYQVACLIGAAWCYGALCMLPPLLGWSKFVISASKLSCSPNWSGQSTADKAYTLLLVTFGFFAPLTVMIISYYKTFW 2
1 VVRRHFVPGNTAVQLRQRKSMLRIVHVTLMSVISMMLSWAPYCFISLASVVRGKPVIENWEAEIPELLAKASVVYNPLIYTFMNKSFRMTLFRIVGLHRCFGAGHEVAPTAAIQKRPNVLQIQFHRHSSEVEVRTPRVPPIE* 0</font>
<font color ="purple">>CTENOP1_plePil Pleurobrachia pileus (sea_gooseberry) Cten.Typh.Pleu FP995093 CU419614 full G? ctenop EQY
0 MELRVSLSLIMACVCTGSVF 1
2 GNMLVFISLVKERPLPNPAVEMIFRHLSLANLVLAGIGEPLVVVSLAA 1
2 GKWVWGESMRYFEAFWVTTFGLFSMMILGLISFEQYSRFVRQKQLKTHQ 0
0 VAVLLSGIYFLAFFFGIAPLVGWCEYGPE 1
2 GYGVSNSLMWNNLNDNNASYIICAMIIGYFFPLIIIMFCYRAIYRLVQ 0
0 AQLNTSVVKMTVSANVTSLSTNRNHIML 0
0 VQERQLASTITFVILSFFFAWTPYVFVNIINMFSTLILKYRILAT 0
0 IPALFAKSSTLWWIIVYCLMDVRIKKACRKTCLRFKRSFRVWYFS* 0
>CTENOP1_mneLei Mnemiopsis leidyi AGCP01013851 AGCP01013853 77% identical CTENOP1_plePil
0 MGLRISLSIAMGCVCVGSVF 1
2 GNLLVLISLVRERPLPNPAVQLIFRHLSLANFLLACIGEPLVVISLAS 1
2 GKWVWGESMRLFEAFWVTTFGLLSMMILALISLEQYSRFVRQKQLRTVQ 0
0 VAVLLSGIYFLAFFFGIAPLVGWCEYGPE 1
2 GYGVSNSLLWNELTDNSASYIVTVMIVGYFFPLVIITYCYRSIYQLVQ 0
0 AQSNVAIVRTMVSVNVTSLAVNRNHSLI 0
0 VQERKLATTITFVILSFFFAWTPYVLINLLNMFTTWVVKYKILAT 0
0 IPALFAKSSTLWWIIIYSMMDKRIKKACRKTCEHFQRALRIWYFSS* 0
>CTENOP2_plePil Pleurobrachia pileus (sea_gooseberry) Cten.Typh.Pleu FQ011385 ERY 33-203 range in bosTau rhodopsin
0 MTTAVDDEMMGDEEPKVVYTLASLLAVNALCSIA 1
2 GNALVIYTFLKEKPLGAPLRVILTHLAVTNLIIASIGEPMVVISGYS 1
2 MRWVFGEMGRGFEAFIVTSCGLMAMSLLALVSIERYLR 2
1 VTPRQRFPFTEPTAVKCCSFLWVFNVIYASLPFYGIAAWEGE 1
2 GIGISNSITWTTEHTQDFVYIICMMSTGYFIPLFIIAFCY  2
>CTENOP2_mneLei Mnemiopsis leidyi AGCP01013109 AGCP01013108 AGCP01013106
0 MSSPNDEPTVDSDPKAVYILTSLLCMNCIFSLV 1
2 GNMLVIYTFLRERPLGAPLRTILCHLAITNLMIAGIGEPMVVISGFN 1
2 VRWVFGEMGRKIEAYTVTASGLMAMSLLAFVSIERYLR 2
1 VTPGQKFLIRQTTSVRVCTLMWIYNVIYASLPFYGIAAWRGE 1
2 GIGISNSLSWDTNNKIDVAYVMVMMATGYFIPLAVITFCYNRYVEIQQRLSTFL 2
  SKLKMTMETNITSAANSQN
0 AAEKKISNVVAIIIVSFFISWTPYTIVNLLVTFDKAGR 2
1 GINATIPAFLAKTSTVWSPIIYCFMNGEVSIFVLEGGHVMKYLYL* 0</font>


The optics of the growing lungfish eye: Lens shape, focal ratio and pupillary movements in Neoceratodus forsteri (Krefft, 1870).
=== GPCR outgroup sequences ===
  Helena J Bailes , Ann E O Trezise , Shaun P Collin
Lungfish (order Dipnoi) evolved during the Devonian period and are believed to be the closest living relatives to the land vertebrates. Here we describe the previously unknown morphology of the lungfish eye in order to examine ocular adaptations present in early sarcopterygian fish. Unlike many teleosts, the Australian lungfish Neoceratodus forsteri possesses a mobile pupil with a slow pupillary response similar to amphibians. The structure of the eye changes from juvenile to adult, with both eye and lens becoming more elliptical in shape with growth. This change in structure results in a decrease in focal ratio (the distance from lens center to the retina divided by the lens radius) and increased retinal illumination in adult fish. Despite a degree of lenticular correction for spherical aberration, there is considerable variation across the lens. A re-calculation of spatial resolving power using measured focal ratios from cryosectioning reveals a low ability to discriminate fine detail. The dipnoan eye shares more features with amphibian eyes than with most teleost eyes, which may echo the visual needs of this living fossil.


AAD30519 coelocanth
[[Image:OpsinOrigins.jpg|left]]
>RHO1_Scyliorhinus canicula (catshark)
mngtegenfy ipmsnktgvv rspfdypqyy laepwkfsvl aaymffliia gfpvnfltly
      61 vtiqhkklrq plnyillnla vadlfmifgg fpstmitsmn gyfvfgpsgc nfegffatlg
      121 geiglwslvv laieryvvvc kpmsnfrfgs qhafmgvglt wimamacafp plvgwsryip
      181 egmqcscgid yytlkpevnn esfviymfvv hfsipltiif fcygrlvctv keaaaqqqes
      241 ettqraerev trmviimvia flicwlpyas vaffifcnqg sefgpifmti paffakaasl
      301 ynpliyilmn kqfrncmitt iccgknpfee eestsasask teassvsssq vapa


browser details OPNLW_ornAna    1087    1  364  364 100.0%  Ultra401  +-     228519    239398  10880
It is sometimes convenient to have a close-in outgroup to opsins selected from the roughly 100,000 GPCR receptors available at GenBank. The set below of 29 non-opsin GPCRs serves satisfactorily as proxy for an exhaustive GPCR compilation. It was constructed by taking best-blast in turn of each human opsin against all other human GPCR then collating the lists, winnowing out repeated entries and too-recent gene family expansions. TACR2 (tachykinin receptor) and SSTR1 (somatostatin receptor) are the best single representatives.
browser details OPNSW2_ornAna  1085    1  363  363 100.0%  Ultra401  +-     258788    263967  5180
>OPNLWS_ornAna green cone Ultra401:228519-239398
>OPNSWS2_ornAna blue cone Ultra401:258788-263967
Ultra401:239378-258808


platypus inline tandems intergenic gap 19,391 bp 10880 span 5180 span
These are usefully supplemented with non-opsin GPCR having determined 3D structures, some nearest neighbors in recent GRAFS classification trees, and two astonishingly close pre-opsins (called UROPS1 and UROPS2 here) from Trichoplax, an early diverging eukaryote lacking opsins. Note TSHR binding of heterotrimeric G protein has recently been [http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0009745 modeled] in great detail.
<--LWS--<19k<--SWS2<
any internal intron markers? larger gen duP
how far back? chicken/liz? xenopus? teleost?


probably very old association because 5 opsins in lamprey already. so if truly tandem, then has to be very old conserved-synteny dupl pre-lamprey
The aligned sequences below have been trimmed from full length at both ends to the earliest indications of conservation. This alignable region begins at the [[Opsin_evolution:_informative_indels#Alignment_in_TM2_region:_420_curated_opsins|GN region]] of TM1 and extends to the [[Opsin_evolution:_Cytoplasmic_face#The_carboxy-terminal_tail_and_VxPx_motif|FR motif]] just beyond TM7. Highly conserved residues are shown in red and less conserved residues in blue. The Schiff base lysine (position -16 relative to the FR end of TM7) does not occur outside of opsins. Note many conserved patches in these GPCR are very similar to those of opsins, implying those residues have no utility in distinguishing opsins from non-opsins.
chicken genome missing but in mrna don't need
lizard both  scaffold_406:780,156-815,073
frog both scaffold_275:171,667-235,246 but showing signs of 3rd lws frag pseudo
zfish oddly has 4=3+1 in a row!  chr11:26,179,088-26,677,303 but still all about sws2 and lws1
unfortunately no chance of callo contig
lamprey be a mess
branchio lacks all cones


>OPNLW_ornAna green cone -Ultra401:228519-23939 minus strand
Conserved outgroup residues shared with opsins evidently describe commonalities needed for generic GPCR structure and signaling but not specifically for photobiology. Departures from the norm in certain opsin classes might indicate they are no longer signaling or are signaling constituitively. Opsins also have conserved diagnostic residues and even [[Opsin_evolution:_informative_indels#Indels_in_the_TM4-EC2-TM5_region|regions]] not found in any GPCR.
MTPAWNSGVYAARRRFEDEEDTTRTSVFVYTNSNNTRDPFEGPNYHIAPRWAYNVTSLWM
IFVVIASVFTNGLVLVATMKFKKLRHPLNWILVNLAVADLGETLIASTISVINQIFGYFI
LGHPMCVLEGYTVSLCGITGLWSLSIISWERWIVVCKPFGNVKFDAKLAMVGIVFSWVWA
AVWTAPPIFGWSRYWPHGLKTSCGPDVFSGSSDPGVQSYMIVLMSTCCILPLSIIVLCYL
QVWLAIRAVAKQQKESESTQKAEKEVSRMVVVMILAYCFCWGPYTIFACFAAANPGYAFH
PLAAALPAYFAKSATIYNPIIYVFMNRQFRNCIMQLFGKKVDDGSELSSTSRTEVSSVSSVSPA*


>OPNSW2_ornAna blue cone -Ultra401:258788-263967 minus strand
These close-in outgroup sequences illuminate, as discussed elsewhere, the [[Opsin_evolution:_orgins_of_opsins#Introduction:_the_origin_of_opsins|origin of opsins]].
MHKTHRNLQNELPEDFFIPLPLDTDNITSLSPFLVPQTHLGGSGIFMSLAAFMFLLITLG
FPINLLTVICTIKYKKLRSHLNYILVNLAVSNMLVVCVGSATAFYSFAHMYFVLGPTACK
IEGFAATLGGMVSLWSLAVIAFERFLVICKPLGNLSFRGTHAIFGCAATWVFGLAASLPP
LFGWSRYIPEGLQCSCGPDWYTTNNKWNNESYVIFLFSFCFGVPLSIIIFSYGRLLLTLR
AVAKQQEQSATTQKAEREVTKMVIVMVLGFLVCWLPYASFSLWVVTNRGQVFDLRMASIP
SVFSKASTIYNPIIYVFMNKQFRSCMLKLVFCGKSPFGDEDEISGSSQATQVSSVSSSQVSPA*


[[Image:OpsinOutgroup.jpg]]


Here's a memo i wrote on 4 color vision in platypus ancestor:
Exon count refers to trimmed alignable sequences. Some idiosyncratic loops have been deleted. Intron positions and phases are indicated relative to bovine
 
rhodopsin numbering (sometimes uncertain due to gapping issues). These GPCR [[Opsin_evolution:_ancestral_introns#Deep_ancestral_introns|do not]] significantly conserve major opsin introns, so parental relations remain obscure.
From:   tom@cyber-dyne.com
Subject: proof that ancestral mammal had trichromatic vision
>GPR21_homSap Homo sapiens (human) orphan receptor good match mollusk opsin 1 exon
Date: September 7, 2007 11:41:38 AM PDT
IVFLTVLIISGNIIVIFVFHCAPLLNHHTTSYFIQTMAYADLFVGVSCVVPSLSLLHHPLPVEESLTCQIFGFVVSVLKSVSMASLACISIDRYIAITKPLTYNTLVTPWRLRLCIFLIWLYSTLVFLPSFFHWGKPGYH
To:   platypus@watson.wustl.edu
GDVFQWCAESWHTDSYFTLFIVMMLYAPAALIVCFTYFNIFRICQQHTKDISERQARFSSQSGETGEVQACPDKRYAMVLFRITSVFYILWLPYIIYFLLESSTGHSNRFASFLTTWLAISNSFCNCVIYSLSNSVFQR
 
wes,
>GPR52_homSap Homo sapiens (human) orphan receptor immediate outgroup to opsins 1 exon
 
IVLLTFLIIAGNLTVIFVFHCAPLLHHYTTSYFIQTMAYADLFVGVSCLVPTLSLLHYSTGVHESLTCQVFGYIISVLKSVSMACLACISVDRYLAITKPLSYNQLVTPCRLRICIILIWIYSCLIFLPSFFGWGKPGYH
I really like the new title. The broader constituency probably prefers ancestral mammal genome content to platypus-specific biology; the platypus divergence date nicely breaks up the long branch to chicken and anole. I worked out a longwinded example below illustrating how the platypus genome can successfully bridge a long-standing gap in our understanding of mammalian color vision evolution.
GDIFEWCATSWLTSAYFTGFIVCLLYAPAAFVVCFTYFHIFKICRQHTKEINDRRARFPSHEVDSSRETGHSPDRRYAMVLFRITSVFYMLWLPYIIYFLLESSRVLDNPTLSFLTTWLAISNSFCNCVIYSLSNSVFRL
 
I had to carefully distinguish genomic reconstructions of last common ancestors (beyond our remit) from initial inferences based on early assemblies of extant species. Absence of assembly evidence does not constitute evidence of genomic absence but more commonly lack of coverage, even when unused raw traces among the 33,353,710 total are consulted.
>MTNR1A_homSap Homo sapiens (human) melatonin receptor circadian rhythm 2 exons 71-12
 
  LIFTIVVDILGNLLVILSVYRNKKLRNA 1
Protein-coding genes in the platypus have been evolving fairly rapidly under selection over the same 166 million years as eutherians -- the tree of life is right-justified. While 'living fossils' do exist (species with slowly evolving proteomes), the platypus is not one of them. On the contrary, picking a protein at random from pre-bilateran Nematostella and employing blastp against all mammals, the human ortholog is most commonly top hit (ie least evolved). Platypus proteins rarely surface as best-blast.
2 GNIFVVSLAVADLVVAIYPYPLVLMSIFNNGWNLGYLHCQVSGFLMGLSVIGSIFNITGIAINRYCYICHSLKYDKLYSSKNSLCYVLLIWLLTLAAVLPNLRAGTLQYDPRIYSCTFAQ
 
SVSSAYTIAVVVFHFLVPMIIVIFCYLRIWILVLQVRQRVKPDRKPKLKPQDFRNFVTMFVVFVLFAICWAPLNFIGLAVASDPASMVPRIPEWLFVASYYMAYFNSCLNAIIYGLLNQNFRK
Comparative genomics does not support the conceit of evolutionary progress chugging steadily along to a pinnacle of human innovation even as primitive creatures drop by the wayside for want of manifest destiny. We know today the platypus genome does not encode any ancient, ancestral, antiquated, archaic, dead-end, failed-experiment, fossil, frozen, primitive, primordial, relic, retro or stationary genes. Indeed platypus genes in conserved syntentic position to bird and lizard homologs but lost in human represent genome content (and often functionality) conserved in ancestral mammal but gone in placentals.
 
>HRH2_homSap Homo sapiens (human) histamine receptor 1 exon
As well-known example, contemporary amniote eyes have demonstrably superior color vision (four cone opsins and improved spectral resolution from pigmented oil droplets) relative to those of nocturnally degenerated placental mammal, as proposed by Gordon Walls in 1942 (ref 1).
LAVLILITVAGNVVVCLAVGLNRRLRNLTNCFIVSLAITDLLLGLLVLPFSAIYQLSCKWSFGKVFCNIYTSLDVMLCTASILNLFMISLDRYCAVMDPLRYPVLVTPVRVAISLVLIWVISITLSFLSIHLGWNS
 
RNETSKGNHTTSKCKVQVNEVYGLVDGLVTFYLPLLIMCITYYRIFKVARDQAKRINHISSWKAATIREHKATVTLAAVMGAFIICWFPYFTAFVYRGLRGDDAINEVLEAIVLWLGYANSALNPILYAALNRDFRT
Opsins don't lend themselves to simple homology-based parsimony reconstructions because of evolutionary convergence of experimentally accessible (spectroscopic) properties and lineage-specific expansions and contractions. What's needed here are complete genomes and syntenic validation of orthology, which we lack to a certain degree here in key species (eg 3 of 6 known chicken opsins are missing from its current assembly).
 
  >SSTR1_homSap Homo sapiens (human) somatostatin receptor SOG Rgamma class 1 exon
However using the platypus genome, I've now been able to reliably reconstruct the cone opsin situation in ancestral mammal, building on ref 2. This is a difficult argument because platypus assembly initially exhibits only exon 5 of an opsin gene clustering to the short wavelength sensitive opsin SWS1 (as observed in ref 2).
  YSVVCLVGLCGNSMVIYVILRYAKMKTATNIYILNLAIADELLMLSVPFLVTSTLLRHWPFGALLCRLVLSVDAVNMFTSIYCLTVLSVDRYVAVVHPIKAARYRRPTVAKVVNLGVWVLSLLVILPIVVFSRT
 
  AANSDGTVACNMLMPEPAQRWLVGFVLYTFLMGFLLPVGAICLCYVLIIAKMRMVALKAGWQQRKRSERKITLMVMMVVMVFVICWMPFYVVQLVNVFAEQDDATVSQLSVILGYANSCANPILYGFLSDNFKR
Close synteny analysis of the gapless platypus assembly contig 45.4 using a conserved non-coding phastCons marker and adjacent CALU gene shows that exons 1-4 do not lie in adjacent assembly gaps but were lost in a multi-kbp deletion. Exon 5 exhibits a small number of disabling non-synonymous changes despite retaining overall high (63%) sequence identity to human, consistent with millions of years of normal divergence followed by rapid neutral evolution after the deletion of exons 1-4 pseudogenized residual exon 5. The deletion can be heuristically dated to perhaps 40 mya, an estimate that echidna SWS1 sequence would greatly improve. No opsin data currently exists for echidna; they may retain functional SWS1.
   
 
  >OPRM1_homSap Homo sapiens (human) opioid receptor mu 3 exons 64-21 182-12 ?
It follows that ancestral monotreme resp. ancestral mammal had 3-color vision (one step down from ancestral amniote) even though the platypus itself today has 2-color vision (similar to marsupials and most placentals). (This assumes intact SWS1 was not exapted to some unrelated function; this is testable from its spectral reconstruction.)
  YSIVCVVGLFGNFLVMYVIVR 2
 
  1 YTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGTWPFGTILCKIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVMFMATTKYRQ 1
contempory:
  2 GSIDCTLTFSHPTWYWENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALVTIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKR
  chicken  (SWS1 SWS2 LWS RHO2 RHO1) 4-color cone vision + 1 rod opsin
   
  platypus (SWS1- SWS2  LWS ---  RHO1) 2-color cone vision + 1 rod opsin
  >GALR1_homSap Homo sapiens (human) galanin receptor SOG Rgamma 3 exons 225-00 251-00 ?
  marsupial (SWS1 ---  LWS --- RHO1) 2-color cone vision + 1 rod opsin  
  FGLIFALGVLGNSLVITVLARSKPGKPRSTTNLFILNLSIADLAYLLFCIPFQATVYALPTWVLGAFICKFIHYFFTVSMLVSIFTLAAMSVDRY
  elephant (SWS1 ---  LWS --- RHO1) 2-color cone vision + 1 rod opsin
  VAIVHSRRSSSLRVSRNALLGVGCIWALSIAMASPVAYHQGLFHPRASNQTFCWEQWPDPRHKKAYVVCTFVFGYLLPLLLICFCYAK 0
  human     (SWS1    LWSa/LWSb    RHO1) 3-color cone vision + 1 rod opsin
  0 VLNHLHKKLKNMSKKSEASKKK 0
 
  0 TAQTVLVVVVVFGISWLPHHIIHLWAEFGVFPLTPASFLFRITAHCLAYSNSSVNPIIYAFLSENFRK
ancestral:
   
  amniote  (SWS1  SWS2  LWS RHO2 RHO1) 4-color cone vision + 1 rod opsin
  >CCR4_homSap Homo sapiens (human) chemokine (C-C motif) receptor 1 exon
  mammal    (SWS1 SWS2 LWS --- RHO1) 3-color cone vision + 1 rod opsin
YSLVFVFGLLGNSVVVLVLFKYKRLRSMTDVYLLNLAISDLLFVFSLPFWGYYAADQWVFGLGLCKMISWMYLVGFYSGIFFVMLMSIDRYLAIVHAVFSLRARTLTYGVITSLATWSVAVFASLPGFLFSTCY
  theran    (SWS1 ---  LWS --- RHO1) 2-color cone vision + 1 rod opsin  
TERNHTYCKTKYSLNSTTWKVLSSLEINILGLVIPLGIMLFCYSMIIRTLQHCKNEKKNKAVKMIFAVVVLFLGFWTPYNIVLFLETLVELEVLQDCTFERYLDYAIQATETLAFVHCCLNPIIYFFLGEKFRK
  placental (SWS1  ---   LWS ---  RHO1) 2-color cone vision + 1 rod opsin
  hominids (SWS1    LWSa/LWSb    RHO1) 3-color cone vision + 1 rod opsin
  >BDKRB2_homSap Homo sapiens (human) bradykinin receptor 1 exon
 
LWVLFVLATLENIFVLSVFCLHKSSCTVAEIYLGNLAAADLILACGLPFWAITISNNFDWLFGETLCRVVNAIISMNLYSSICFLMLVSIDRYLALVKTMSMGRMRGVRWAKLYSLVIWGCTLLLSSPMLVFRTMKEYS
 
DEGHNVTACVISYPSLIWEVFTNMLLNVVGFLLPLSVITFCTMQIMQVLRNNEMQKFKEIQTERRATVLVLVVLLLFIICWLPFQISTFLDTLHRLGILSSCQDERIIDVITQIASFMAYSNSCLNPLVYVIVGKRFRK
Details:
 
  >GPR17_homSap Homo sapiens (human) uracil/cys-leukotriene dual receptor 1 exon
Queries by known SWS1 genes -- but not other opsins -- return a strong match to platypus chr10:3,960,795-3,960,908, which translates to FHACIMEMMRGKLMVDDSESSSQETKTSTVSSRQVGPS* with conserved intron position and phase zero characteristic of SWS1 exon 5. The 11,205 bp contig 45.4 also contains terminal exons of long-conserved syntenic gene CALU in the expected opposite strand orientation. Total coding gene span seems short enough (3,646 bp in opossum, 3,248 bp in human, 11,959 bp in anole) that the contig might be expected to contain some or all of exons 1-4 as well, even adjusting contig length to reflect observed lineage-specific retroposons of platypus. However exons 1-4 are missing from the contig and indeed the assembly. Furthermore missing exons cannot be found among GenBank transcripts now raw trace reads which include singleton reads and reads from other centers not used in the assembly.
  YLLDFILALVGNTLALWLFIRDHKSGTPANVFLMHLAVADLSCVLVLPTRLVYHFSGNHWPFGEIACRLTGFLFYLNMYASIYFLTCISADRFLAIVHPVKSLKLRRPLYAHLACAFLWVVVAVAMAPLLVSPQT
 
  VQTNHTVVCLQLYREKASHHALVSLAVAFTFPFITTVTCYLLIIRSLRQGLRVEKRLKTKAVRMIAIVLAIFLVCFVPYHVNRSVYVLHYRSHGASCATQRILALANRITSCLTSLNGALDPIMYFFVAEKFRH
This raises the question whether platypus lacks full length SWS1 or whether exons 1-4 merely lie in nearby gaps of the current 6x assembly. Possibly earlier introns have expanded so much that exons 1-4 have been pushed off the contig into these gaps. However contig 45.4 contains the phylogenetically conserved non-coding phastCons element lod109 (ref 3) at its extreme 3' end chr10:3,964,439-3,964,588 (the contig ends at 3,964,658!).
   
 
  >CYSLTR1_homSap Homo sapiens (human) cys-leukotriene receptor 1 exon
The UCSC genome browser provides putative orthologs of lod109 in marsupial and placental. These blat as standalone queries into full syntenic position with matching strand orientation with respect to marsupial and mouse where they are named lod15+lod45 and lod78 respectively. Here phastCons strand convention, which is inherently arbitrary, can be taken as positive for platypus and carried forward to mouse and oppossum. CALU is positive but SWS1 exon 5 is negative in all three species.
YSMISVVGFFGNGFVLYVLIKTYHKKSAFQVYMINLAVADLLCVCTLPLRVVYYVHKGIWLFGDFLCRLSTYALYVNLYCSIFFMTAMSFFRCIAIVFPVQNINLVTQKKARFVCVGIWIFVILTSSPFLMAKPQKDE
 
  KNNTKCFEPPQDNQTKNHVLVLHYVSLFVGFIIPFVIIIVCYTMIILTLLKKSMKKNLSSHKKAIGMIMVVTAAFLVSFMPYHIQRTIHLHFLHNETKPCDSVLRMQKSVVITLSLAASNCCFDPLLYFFSGGNFRK
Thus exons 1-4 of platypus are required to lie between SWS1 exon 5 and lod109, a region spanned by a single gapless contig, but they do not. This requires either a deletion or translocation elsewhere (to a trace read and assembly gap). A local inversion might move exons 1-4 into an assembly gap but that would disrupt reading frame. Implausibly, the missing exons could be translocated into an adjacent bridged gap of estimated modest size preceding the right-flanking gene NAG6 while retenting strand; this is incompatible with all four exons remaining recalcitrant to repeated attempts at genomic amplification (ref 2) and still missing in 6x coverage.
   
 
  >P2RY8_homSap Homo sapiens (human) purinergic receptor AMIN Ralpha class 1 exon
In summary, SWS1 is non-functional in platypus because the highly conserved exons 1-4 critical to opsin structure and function have been deleted. Conceivably this could be a copy-number polymorphism specific to the individual female platypus chosen for the genome project -- a seemingly viable concern given such polymorphisms are common for the tandem chrX opsin array in human. [Note the current human assembly shows 3 tandem opsins on chrX!] However platypus SWS1 does not lie in tandem array that might foster frequent inhomogeneous recombination. Human colorblindness involving loss of orthologous SWS1 is quite rare.
YSLVAAVSIPGNLFSLWVLCRRMGPRSPSVIFMINLSVTDLMLASVLPFQIYYHCNRHHWVFGVLLCNVVTVAFYANMYSSILTMTCISVERFLGVLYPLSSKRWRRRRYAVAACAGTWLLLLTALSPLARTDLTY
 
PVHALGIITCFDVLKWTMLPSVAMWAVFLFTIFILLFLIPFVITVACYTATILKLLRTEEAHGREQRRRAVGLAAVVLLAFVTCFAPNNFVLLAHIVSRLFYGKSYYHVYKLTLCLSCLNNCLDPFVYYFASREFQL
Further close analysis of exon 5 shows the deletion event lies between ancient and recent:
   
 
  >HCRTR1_homSap Homo sapiens (human) orexin receptor Rbeta class 7 exons 57-12 117-00 187-12 226-00 276-21 310-12
Alignment of orthologous exons from 19 species phylogenetically bracketing platypus establish an arginine anomalously replacing conserved cysteine and a one residue deletion in platypus but otherwise very respectable percent identity that is not compatible with gene loss 166 mya ago (date for divergence taken in platypus paper). Non-selected pseudogenized coding dna does not leave detectable remnants at this age -- indeed no remnants can be detected of amniote RHO2 in mammals nor SWS2 in therans even focusing the search on syntenic dna, ref 2 and here.
  YVAVFVVALVGNTL 1
 
  2 VCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQ 0
>OPNSWS1_xenTro FRGCIMETVCGRPMTDDSSVSSTSQKTEVSTVSSSQVSPA* amphibian
0 AVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWA 1
>OPNSWS1_anoCar FRACILETVCGKPMSDESDVSSSAQKTEVSSVSSSQVSPS* lizard
  2 DDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQ 0
>OPNSWS1_pheMad FRGCIMEMVCGKPMSDDSEASTS-QKTEVSSVSSSQVSPS* lizard
0 IPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRGRAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKR 2
>OPNSWS1_gekGek FRGCILEMVCGKTMAEESEVSSASQKTEVSSVSSSQVGPS* lizard
  1 VFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLS 1
>OPNSWS1_utaSta FRACIMETVCGKPMTDESDVSSSAQKTEVSSVSSSQVSPS* lizard
2 GKFRE
>OPNSWS1_galGal FRACIMETVCGKPLTDDSDASTSAQRTEVSSVSSSQVGPT* bird
>OPNSWS1_taeGut FRACIMETVCGRPMTDDSEVSSSAQRTEVSSVSSSQVGPS* bird
>TACR2_homSap Homo sapiens (human) tachykinin receptor Gq-coupled SOG Rgamma class first gc-ag 5 exons 135-21 202-21 250-00 ? 312-21
>OPNSWS1_phaCar FRACIMETVCGKPMADDSEASSSAQRTEVSSVSSSQVSPS* bird
  YLALVLVAVTGNAIVIWIILAHRRMRTVTNYFIVNLALADLCMAAFNAAFNFVYASHNIWYFGRAFCYFQNLFPITAMFVSIYSMTAIAADR 2
>OPNSWS1_ancMam FHACIMEMVCGKPMTDDSdVSSS-QKTEVSTVSSSQVGPS* ancestral mammal
1 YMAIVHPFQPRLSAPSTKAVIAGIWLVALALASPQCFYSTVTMDQGATKCVVAWPEDSGGKTLLL 2
>OPNSWS1_ornAna FHACIMEMMRGKLMVDDSE-SSS-QETKTSTVSSRQVGPS* monotreme
1 YHLVVIALIYFLPLAVMFVAYSVIGLTLWRRAVPGHQAHGANLRHLQAMKK 0
>OPNSWS1_monDom FHACIMEMVCRKPMTDDSDVSSS-QKTEVSAVSSSQVGPT* marsupial opossum Didelphimorphia
0 FVKTMVLVVLTFAICWLPYHLYFILGSFQEDIYCHKFIQQVYLALFWLAMSSTMYNPIIYCCLNHR 2
>OPNSWS1_macEug FHACIMEMVCRKPMTDDSEASSS-QKTEVSTVSSSQVGPS* marsupial wallaby Diprotodontia
1 FRS
>OPNSWS1_smiCra FHACIMEMICKKPMTDDSETTSS-QKTEVSTVSSSQVGPS* marsupial dunnart Dasyuromorphia
>OPNSWS1_setBra FHACIMEMVCRKPMTDDSEASSS-QKTEVSTVSSSQVGPS* marsupial quokka Diprotodontia
>NMUR2_homSap Homo sapiens (human) neuromedin U receptor 4 exons 229-00 ? 256-12 291-12
>OPNSWS1_isoObe FHACIMEMICRKPMTDDSETSSS-QKTEVSTVSSSQVSPS* marsupial bandicoots Peramelemorphia
  YVPIFVVGVIGNVLVCLVILQHQAMKTPTNYYLFSLAVSDLLVLLLGMPLEVYEMWRNYPFLFGPVGCYFKTALFETVCFASILSITTVSVERYVA
>OPNSWS1_canFam FRACIMEMVCGKSMTEDSEMSSS-QKTEVSTVSPSQVGPN* placental
ILHPFRAKLQSTRRRALRILGIVWGFSVLFSLPNTSIHGIKFHYFPNGSLVPGSATCTVIKPMWIYNFIIQVTSFLFYLLPMTVISVLYYLMALR 0
>OPNSWS1_susScr FRACIMEMVCGKPMTDESDMSSS-QKTEVSTVSSTQVGPN* placental
0 LKKDKSLEADEGNANIQRPCRKSVNKML 1
>OPNSWS1_homSap FQACIMKMVCGKAMTDESDTCSS-QKTEVSTVSSTQVGPN* placental
2 FVLVLVFAICWAPFHIDRLFFSFVEEWSESLAAVFNLVHVVS 1
>OPNSWS1_sciBol FRACIMEMVCGKAMTDESDISSS-QKTEVSTVSSSQVGPN* placental
2 GVFFYLSSAVNPIIYNLLSRRFQA
>OPNSWS1_cavPor FRACIMELVCRKPMADESDMSTS-QKTEVSAVSSSKVGPN* placental
>OPNSWS1_musMus FRACILEMVCRKPMADESDVSGS-QKTEVSTVSSSKVGPH* placental
>QRFPR_homSap Homo sapiens (human) pyroglutamylated RFamide peptide receptor MEC Ralpha class 6 exons 105-12 157-12 180-00 247-21 277-12
    Consensus FraCImEmvcgkpMtD#S#.sss.QkTevStVSSsqVgP.*
  GVLIFALALFGNALVFYVVTRSKAMRTVTNIFICSLALSDLLITFFCIPVTMLQNISDNWLG 1
 
2 GAFICKMVPFVQSTAVVTEILTMTCIAVERHQGLVHPFKMKWQYTNRRAFTML 1
The anomalous arginine can be validated in raw trace data, necessary because the trace assembly process resolves discrepancies by quality scores weighting that might disadvantage a read more accurate locally at the cysteine position. Viewing original data requires blastn against sepaate platypus WGS and OTHER databases at the NCBI trace archive repository. Some 752,000 additional traces from TIGR and NISC are found there in addition to 3,595,283 cDNA WUGSC traces. These numbers are a significant addition to the 27,607,516 conventional WGS traces used (but not used up) in the current platypus assembly.
2 GVVWLVAVIVGSPMWHVQQLE 0
 
0 IKYDFLYEKEHICCLEEWTSPVHQKIYTTFILVILFLLPLMVMLILYSKIGYELWIKKRVGDGSVLRTIHGKEMSKIAR 2
The usual error types occur in these traces but none would result in R --> C and similarly for the 3bp indel. This cysteine is deeply conserved in homologous position in other opsins such as RHO1, SWS2, and LWS though there is 6 residues of spacing in the latter two families instead of 5 here.Therefore arginine, manifestly unsuited for a disulfide bond, is not acceptable structurally in this position.  
1 KKKRAVIMMVTVVALFAVCWAPFHVVHMMIEY 1
 
2 SNFEKEYDDVTIKMIFAIVQIIGFSNSICNPIVYAFMNENFKK
The amino acid in platypus is a bit unusual at four other sites, highlighted in red in the alignment. Some of these changes may be incapacitating but others tolerated or even advantageous. While other species have their anomalies as well, platypus is a real outlier in this regard which can be seen for example by MultiAlign tree construction. http://bioinfo.genopole-toulouse.prd.fr/multalin/multalin.html  
 
>GPR19_homSap Homo sapiens (human) orphan receptor 19 1 exon
The alignment contains a heuristic prediction of exon 5 in the last common ancestor of mammals that is useful in counting changes in descendant lineages. Overall platypus exon 5 has evolved anomalously in that its variations are not concentrated at commonly variable positions but disproportionately at conserved ones, a pattern characteristic of a pseudogene. Opsin change is difficult to assess because to be retained over long timeframes, SWS1 and SWS2 in the same species may push each other apart (subfunctionalize) at significant sites that affect absorption spectra (eg color vision) rather than just drift at soft positions.
FGILWLFSIFGNSLVCLVIHRSRRTQSTTNYFVVSMACADLLISVASTPFVLLQFTTGRWTLGSATCKVVRYFQYLTPGVQIYVLLSICIDRFYTIVYPLSFKVSREKAKKMIAASWIFDAGFVTPVLFFYGS
 
NWDSHCNYFLPSSWEGTAYTVIHFLVGFVIPSVLIILFYQKVIKYIWRIGTDGRTVRRTMNIVPRTKVKTIKMFLILNLLFLLSWLPFHVAQLWHPHEQDYKKSSLVFTAITWISFSSSASKPTLYSIYNANFRR
Platypus exon 5 can only have become nonfunctional fairly recently -- retaining 63% identity to human given 332 mya of round-trip evolutionary time is quite respectable and implies long periods of conserved functionality. (Chicken/human have 65% identity.) This degree of conservation is incompatible with ancestral monotreme already having pseudogenized SWS1 from consideration of neutral rates. Thus it appears that a platypus ancestor, possibly prior to echidna divergence at 25 mya (ref 4), still had functional SWS1 and so trichromatic cone vision. That would also be true further back at the ancestral mammalian node because platypus retains SWS2 and LWS, still in amniote-syntenic tandem position at Ultra401:228519-263967 (blat genome or see ref 2).
 
>PPYR1_homSap Homo sapiens (human) pancreatic polypeptide receptor MEC Ralpha class 1 exon
In summary, the preferred scenario is platypus ancestors possessing a functional SWS1 gene evolving at a moderate rate until the fairly recent deletion of exons 1-4. After the deletion the remaining exon 5 had no constraints and so evolved at the faster neutral rate of pseudogenic dna.
YSIETVVGVLGNLCLMCVTVRQKEKANVTNLLIANLAFSDFLMCLLCQPLTAVYTIMDYWIFGETLCKMSAFIQCMSVTVSILSLVLVALERHQLIINPTGWKPSISQAYLGIVLIWVIACVLSLPFLANSILENVFHKNHS
 
KALEFLADKVVCTESWPLAHHRTIYTTFLLLFQYCLPLGFILVCYARIYRRLQRQGRVFHKGTYSLRAGHMKQVNVVLVVMVVAFAVLWLPLHVFNSLEDWHHEAIPICHGNLIFLVCHLLAMASTCVNPFIYGFLNTNFKK
How recent was this deletion? That would require partitioning changes in platypus exon 5 since divergence from ancestral mammal between drift and selective change during the functional era from subsequent neutral change in the pseudogene era, based on anomalous character and what is known generally about opsin evolution and neutral rates in general. That calculation would greatly benefit from determining the sequence and status of exon 5 in echidna. If echidna still had functional SWS1 and the divergence time was 25 mya, the deletion event in platypus must post-date that. On the other hand, if echidna also contained the indel, the departure of its exon 5 sequence from platypus would significantly inform event partitioning and so improve dating of the indel.
 
>NPY1R_homSap Homo sapiens (human) neuropeptide Y receptor Rbeta class 2 exons 225-00
It cannot be proven that intact SWS1 functioned as a cone cell color vision receptor in ancestral platypus (because opsins can be exapted to other purposes); echidna sequence might at least allow appropriateness of its adsorption spectrum to be adduced.
  YGAVIILGVSGNLALIIIILKQKEMRNVTNILIVNLSFSDLLVAIMCLPFTFVYTLMDHWVFGEAMCKLNPFVQCVSITVSIFSLVLIAVERHQ
 
LIINPRGWRPNNRHAYVGIAVIWVLAVASSLPFLIYQVMTDEPFQNVTLDAYKDKYVCFDQFPSDSHRLSYTTLLLVLQYFGPLCFIFICYFK 0
ref 1
0 IYIRLKRRNNMMDKMRDNKYRSSETKRINIMLLSIVVAFAVCWLPLTIFNTVFDWNHQIIATCNHNLLFLLCHLTAMISTCVNPIFYGFLNKNFQR
Walls, GL
The Vertebrate Eye and its Adaptive Radiation
>PRLHR_homSap Homo sapiens (human) prolactin releasing hormone receptor 1 exon
Cran brook Institute 1942
YSVVVVVGLVGNCLLVLVIARVRRLHNVTNFLIGNLALSDVLMCTACVPLTLAYAFEPRGWVFGGGLCHLVFFLQPVTVYVSVFTLTTIAVDRYVVLVHPLRRRISLRLSAYAVLAIWALSAVLALPAAVHTYHVELKP
TOC http://www.crsltd.com/research-topics/walls/index.html
  HDVRLCEEFWGSQERQRQLYAWGLLLVTYLLPLLVILLSYVRVSVKLRNRVVPGCVTQSQADWDRARRRRTFCLLVVVVVVFAVCWLPLHVFNLLRDLDPHAIDPYAFGLVQLLCHWLAMSSACYNPFIYAWLHDSFRE
 
ref 2
>GPR161_homSap Homo sapiens (human) orphan receptor 161 2 exons 135-21
Davies WL, Carvalho LS, Cowing JA, Beazley LD, Hunt DM, Arrese CA
  IIVITIFVCLGNLVIVVTLYKKSYLLTLSNKFVFSLTLSNFLLSVLVLPFVVTSSIRREWIFGVVWCNFSALLYLLISSASMLTLGVIAIDR 2
Visual pigments of the platypus: a novel route to mammalian colour vision.
  1 YYAVLYPMVYPMKITGNRAVMALVYIWLHSLIGCLPPLFGWSSVEFDEFKWMCVAAWHREPGYTAFWQIWCALFPFLVMLVCYGFIFRVARVKARKVHCGTVV
Curr Biol. 2007 Mar 6;17(5):R161-3.
IVEEDAQRTGRKNSSTSTSSSGSRRNAFQGVVYSANQCKALITILVVLGAFMVTWGPYMVVIASEALWGKSSVSPSLETWATWLSFASAVCHPLIYGLWNKTVRK
 
   
ref 3
  >ADRA1D_homSap Homo sapiens (human) alpha-1D-adrenergic receptor PUR Ralpha class 2 exons 274-12
Siepel A, Bejerano G, Pedersen JS, Hinrichs AS, Hou M, Rosenbloom K, Clawson H, Spieth J, Hillier LW, Richards S, et al.
  LAAFILMAVAGNLLVILSVACNRHLQTVTNYFIVNLAVADLLLSATVLPFSATMEVLGFWAFGRAFCDVWAAVDVLCCTASILSLCTISVDRYVGVRHSLKYPAIMTERKAAAILALLWVVALVVSVGPLLGWKEPV
Evolutionarily conserved elements in vertebrate, insect, worm, and yeast genomes.
PPDERFCGITEEAGYAVFSSVCSFYLPMAVIVVMYCRVYVVARSTTRSLEAG VKRERGKASE VVLRIHCRGAATGADGAHGMRSAKGHTFRSSLSVRLLKFSREKKAAKTLAIVVGVFVLCWFPFFFVLPL 1
Genome Res. 2005 Aug;15(8):1034-50.
2 GSLFPQLKPSEGVFKVIFWLGYFNSCVNPLIYPCSSREFKR
>TRHR_homSap Homo sapiens (human) thyrotropin-releasing hormone receptor 2 exons 251-00
  VLIICGLGIVGNIMVVLVVMRTKHMRTPTNCYLVSLAVADLMVLVAAGLPNITDSIYGSWVYGYVGCLCITYLQYLGINASSCSITAFTIERYIAICHPIKAQFLCTFSRAKKIII
FVWAFTSLYCMLWFFLLDLNISTYKDAIVISCGYKISRNYYSPIYLMDFGVFYVVPMILATVLYGFIARILFLNPIPSDPKENSKTWKNDSTHQNTNLNVNTSNRCFNSTVSSRKQ 0
0 VTKMLAVVVILFALLWMPYRTLVVVNSFLSSPFQENWFLLFCRICIYLNSAINPVIYNLMSQKFRA
>TSHR_homSap Homo sapiens (human) thyrotropin receptor 1 exon PM:20305779
VWFVSLLALLGNVFVLLILLTSHYKLNVPRFLMCNLAFADFCMGMYLLLIASVDLYTHSEYYNHAIDWQTGPGCNTAGFFTVFASELSVYTLTVITLERWYAITFAMRLDRKIRLRHACAIMVGGWVCCFLL
ALLPLVGISSYAKVSICLPMDTETPLALAYIVFVLTLNIVAFVIVCCCYVKIYITVRNPQYNPGDKDTKIAKRMAVLIFTDFICMAPISFYALSAILNKPLITVSNSKILLVLFYPLNSCANPFLYAIFTKAFQR
>ADRB2_homSap Homo sapiens (human) beta2 adrenoceptor pdb:2R4R  PUR Ralpha class 1 exon
MSLIVLAIVFGNVLVITAIAKFERLQTVTNYFITSLACADLVMGLAVVPFGAAHILMKMWTFGNFWCEFWTSIDVLCVTASIETLCVIAVDRYFAITSPFKYQSLLTKNKARVIILMVWIVSGLTSFLPIQMHWYRATHQEAINCYAN
ETCCDFFTNQAYAIASSIVSFYVPLVIMVFVYSRVFQEAKRQLQKIDKSEGRFHVQNLSQVEQDGRTGHGLRRSSKFCLKEHKALKTLGIIMGTFTLCWLPFFIVNIVHVIQDNLIRKEVYILLNWIGYVNSGFNPLIYCRSPDFRI
>ADORA2A_homSap Homo sapiens (human) beta2 adenosine receptor pdb:3EML PUR Ralpha class 2 exons 144-21
  ELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFAITISTGFCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLR 2
1 YNGLVTGTRAKGIIAICWVLSFAIGLTPMLGWNNCGQPKEGKNHSQGCGEGQVACLFEDVVPMNYMVYFNFFACVLVPLLLMLGVYLRIFLA
ARRQLKQMESQPLPGERARSTLQKEVHAAKSLAIIVGLFALCWLPLHIINCFTFFCPDCSHAPLWLMYLAIVLSHTNSVVNPFIYAYRIREFRQ
>ADRB1_melGal Meleagris gallopavo (turkey) beta1 adrenergic receptor pdb:2VT4 1 exon
MALVVLLIVAGNVLVIAAIGSTQRLQTLTNLFITSLACADLVVGLLVVPFGATLVVRGTWLWGSFLCELWTSLDVLCVTASIETLCVIAIDRYLAITSPFRYQSLMTRARAKVIICTVWAISALVSFLPIMMHWWRD
EDPQALKCYQDPGCCDFVTNRAYAIASSIISFYIPLLIMIFVALRVYREAKEQIRKIDRASKRKRVMLMREHKALKTLGIIMGVFTLCWLPFFLVNIVNVFNRDLVPDWLFVAFNWLGYANSAMNPIIYCRSPDFRK
>UROPS1_triAdh Trichoplax adhaerens (trichoplax) XM_002114542 ends trimmed 1 exon
YSVLSLITILGNMLVFLTFYKHASLRTTSNLFIINLAITDLLTGGIKDTLFIYGLTSYNWPKSAILCSFVGFINCVCYVATVYTLTVIAVFRYLAIVCNLGRKIKRKHSILTIACVWIYSSACCLMPIIGWSRY
IYEPTECTCVRSLDKKYYSYTIYILVADFLLPLSVVSFCYGNIFAKMKRNHHHIKRDLSDGQKLDVAEKLSRREEIVARRMFIILAEHVVCFLPYTIIVTMLAANGVDIEPVWYFIVGYLLNLNSALNPVTYIVVNPRLKK
   
   
ref 4
>UROPS2_triAdh Trichoplax adhaerens (trichoplax) XM_002112401 ends trimmed 2 exons 241-21 ?
Pettigrew JD.
  0 MTLFMLMSCIGNGAVLLVLRYHHDDIKSASNYFITNLALTDFLLGVLCMPCILISCLNGQWVFGQTLCSLTGFANSFFCINSMITLAAVSVEKYCAIASPLTY
Electroreception in monotremes.
  HHYMSKSKVTCVISIIWIHSAINASLPFLGWGEYVYLPFETICTVAWWSFPNYVGFIVGINFGLPTVIMSCTYFLILKIARKHSRRIGVST 2
J Exp Biol. 1999 May;202(Pt 10):1447-54.
  1 RRIHYKTHIKATLMLLIVIGSFIVCWLPHLISMIYLTIYEISPLPCSFHQITTWLAMANSAFNPIIYGAMDTSIRK
http://jeb.biologists.org/cgi/reprint/202/10/1447
 
>lod109_ornAna+ chr10:3964439-3964588
tgctgctgatgtggcaaagaagaccacatctgtccagctacttctatcaccggctcgttggtctaggggtatgattctcgcttagggtgcgagaggtcccgggttcaaatcccggacgagccctgtttttcccacctggttttatttggg
 
>lod109_monDom+ chr8:184,539,020-184,560,157 from platypus alignment
tgctgatgatgtggcaaaaccacatctggacaactattttcaacactggctcgttggtctaggggtatgattctcgcttagggtgcgagaggtcccgggttcaaatcccggacgagcccaattttac
 
>lod78_musMus+ chr6:29338830-29338906 from platypus alignment
tgttgatgatgtggtagag-aggatacatctggccaggagtaaccgccagtggctcgttggtctaggggtatgattctcgcttagggtgcgagaggtcccgggttcaaatcccggacgagccctgcttatc
 
genomic data availability relative to chicken
LWS galGal- ornAna+ homSap++
SWS2 galGal- ornAna+ homSap+  
SWS1 galGal- ornAna- homSap+
RHO2 galGal+ ornAna- homSap-
RHO1 galGal+ ornAna+ homSap+
PPNG galGal+ ornAna- homSap-
 
>OPNLW_ornAna green cone Ultra401:228519-23939
MTPAWNSGVYAARRRFEDEEDTTRTSVFVYTNSNNTRDPFEGPNYHIAPRWAYNVTSLWM
IFVVIASVFTNGLVLVATMKFKKLRHPLNWILVNLAVADLGETLIASTISVINQIFGYFI
LGHPMCVLEGYTVSLCGITGLWSLSIISWERWIVVCKPFGNVKFDAKLAMVGIVFSWVWA
AVWTAPPIFGWSRYWPHGLKTSCGPDVFSGSSDPGVQSYMIVLMSTCCILPLSIIVLCYL
QVWLAIRAVAKQQKESESTQKAEKEVSRMVVVMILAYCFCWGPYTIFACFAAANPGYAFH
PLAAALPAYFAKSATIYNPIIYVFMNRQFRNCIMQLFGKKVDDGSELSSTSRTEVSSVSSVSPA*
 
>OPNSW2_ornAna blue cone pigment Ultra401:258788-263967
MHKTHRNLQNELPEDFFIPLPLDTDNITSLSPFLVPQTHLGGSGIFMSLAAFMFLLITLG
FPINLLTVICTIKYKKLRSHLNYILVNLAVSNMLVVCVGSATAFYSFAHMYFVLGPTACK
IEGFAATLGGMVSLWSLAVIAFERFLVICKPLGNLSFRGTHAIFGCAATWVFGLAASLPP
LFGWSRYIPEGLQCSCGPDWYTTNNKWNNESYVIFLFSFCFGVPLSIIIFSYGRLLLTLR
AVAKQQEQSATTQKAEREVTKMVIVMVLGFLVCWLPYASFSLWVVTNRGQVFDLRMASIP
SVFSKASTIYNPIIYVFMNKQFRSCMLKLVFCGKSPFGDEDEISGSSQATQVSSVSSSQVSPA*
 
>OPNRH_ornAna rhodopsin rod pigment Ultra20:114,479-118,391
MNGTEGQDFYIPMSNKTGVVRSPFEYPQYYLAEPWQYSVLAAYMFMLIMLGFPINFLTLY
VTIQHKKLRTPLNYILLNLAFANHFMVLGGFTTTLYTSLHGYFVFGPTGCNIEGFFATLG
GEIALWSLVVLAIERYIVVCKPMSNFRFGENHAIMGVAFTWIMALACALPPLVGWSRYIP
EGMQCSCGIDYYTLRPEVNNESFVIYMFVVHFTIPMTIIFFCYGRLVFTVKEAAAQQQES
ATTQKAEKEVTRMVIIMVIAFLICWVPYASVAFYIFTHQGSNFGPIFMTVPAFFAKSSAI
YNPVIYIMMNKQFRNCMLTTICCGKNPLGDDEASATASKTEQSSVSTSQVSPA*
 
>OPNSWS1_ornAna terminal exon chr10:3,935,884-3,985,883
FHACIMEMMRGKLMVDDSESSSQETKTSTVSSRQVGPS*


'''See also:''' [[Opsin_evolution:_LWS_PhyloSNPs|LWS]] | [[Opsin_evolution:_Encephalopsin_gene_loss|Encephalopsins]] | [[Opsin_evolution:_Melanopsin_gene_loss|Melanopsins]] | [[Opsin_evolution:_Neuropsin_phyloSNPs|Neuropsin]] | [[Opsin_evolution:_Peropsin_phyloSNPs|Peropsin]] | [[Opsin_evolution:_RGR_phyloSNPs|RGR phyloSNPs]] | [[Opsin_evolution:_update_blog|Update Blog]]


[[Category:Comparative Genomics]]
[[Category:Comparative Genomics]]

Latest revision as of 15:13, 30 September 2011

See also: LWS | Encephalopsins | Melanopsins | Neuropsin | Peropsin | RGR phyloSNPs | Update Blog

Introduction to Opsin Evolution

The Curated Set of Metazoan Opsins

Below is the largest set of phylogenetically dispersed hand-curated opsin sequences ever assembled. The sequences are organized into true orthology classes using coding indels, intron location and phase, synteny of flanking genes, diagnostic residues, blast clustering, and experimental characterization when available. The reference set of opsin sequences includes selected GenBank entries but mostly new opsins extracted from dozens of newly completed genome projects.

The set serves as a gene family classifier ... just uBlast an unknown candidate opsin against the full database below and look for consistent labeling of the top hits from the Opsin Classifier. Then validate the apparent orthology class using three independent classes of rare genomic events (indels, introns, signature residues) by including the new sequence in a full-width multalignment, being sure to include a couple dozen non-opsin GPCRs as controls. Then check for residual bilateral flanking gene adjacency when a genome assembly is available. The whole process takes only 15 seconds per query!

The set of reference sequences is deliberately not exhaustive -- that seriously over-samples in popular experimental clades such as vertebrates and insects. When a given clade has many similar sequences available, those in species with genome assemblies are chosen to represent the group, for example anole is preferred to gecko, and (rightly or wrongly) any experimental results from gecko transfered over. This avoids the uninformative clutter of near-identical sequences. However if a clade reflects a very deep divergence especially important to opsin evolution (such as lamprey or amphioxus), all available sequences are needed to maximally break up long branches.

Sequences not available from GenBank were culled from trace archives, tiled contigs, and genome assemblies, typically by uBlastx against the growing set of reference sequences, as described in the annotation section. The level of error in the curated sequences is very low, declines with time as anomalies are revisited and repaired, but never reaches zero because of problems inherent to experimental data, imperfect sequencing reads, less-than-complete assemblies, and sequence manipulation.

Rare genomic changes can supplement (and even displace) traditional maximal likelihood and bayesian inference in resolving polytomic divergence nodes in gene and species tree topologies. Rare genomic changes applicable to opsins include coding indels (deletions and insertions), intron placement (position and phase comparison), synteny (gene order along the chromosome), and gene copy number change (gene gain from retropositional, tandem, segmental, and whole genome duplications; gene loss from pseudogenization or deletion). Results from these methods must be evaluated for their susceptibility to homoplasy (misleading recurrent independent events that mimic a single event) and incomplete penetration in the population level at the time of speciation (lineage sorting).

Opsins are more informatively stored as proteins since nucleotide sequences are far too diverged at metazoan evolutionary distances and do not explicitly manifest residue properties that experience selection. These protein sequences are parsed into constituent exons using genomic information when available -- fortunately splicing mechanisms are exceeding well conserved across animal phyla. When not directly available (eg the opsin originated as a cDNA in a species lacking a genome project), exon breaks have been inferred from the phylogenetically closest neighbors via heterologous alignment (but not in insects where intron turnover is too high). As an example, lamprey opsins from Geotria australis and Lethenteron japonicum can work as blastn queries to locate orthologs within the Petromyzon maritimus genome project (which consists solely of 19 million traces as of mid-December 2007).Numbers flanking exons, namely 0 1 2, show the phasing of each intron, eg 12 means an overhang of 1 bp at the 3' end of an exon with fragmentary codon completed by a 2 bp overhang at the beginning of the next exon.

Intron position and phasing are conserved over vast evolutionary distances -- human to sponge and beyond -- with the exception of certain rogue lineages (that unfortunately includes two major model organisms). Informative conservation is still available long after protein percent identity has slid into the twilight zone of uncertainty (critical in opsins because they are readily confused with generic GPCR receptors). For example, no variation whatsoever in intron pattern has occurred in any vertebrate opsin class since lamprey divergence, no events in many billions of years of branch length. Prior to that, rare events are observed, for example LWS opsins gained an extra intron of phase 12. In a protein having 333 locations with 3 possible phases at each location, convergent evolution (homoplasy) is uncommon, that is, close examination establishes opsin introns are still highly informative even when sequences have greatly diverged.

Insertions and deletions (coding indels) are sufficiently uncommon in opsins that they are a potentially phylogenetically informative class of rare genomic events. We'll harvest these from a massive opsin alignment and stratify by location and phylogenetic depth. Indels are more subject to homoplasy than intron gain or loss but the risk of that varies greatly by region. Indels are less affected by lineage-specific rates than other event classes.

Syntentic relationships can have great value in determining orthology relationships, though gene order is not often conserved over great evolutionary timescales due to chromosomal rearrangements. As with introns, certain rogue lineages lose almost all this information. Tracking synteny is nomenclaturally confused because many genes are unnamed and simply numbered by annotation pipeline procedures in each genome without homological consistency. Here, HUGO-convention names are used for two genes flanking each side of a given human opsin. Strand orientation is noted relative to a fixed convention of plus strand for the human opsin. Then each genome assembly is visited to determine the extent of conservation of these flanking genes and orientation. In the event humans lack the gene, synteny is defined by the nearest diverging species, typically platypus or chicken, that has the gene. Sometimes the original synteny is only partly retained (left or right half-synteny). For deeply diverging species such as amphioxus, flanking genes can be are pushed forward into 'nearby' species. This can also be done without an assembly in species with sufficiently large contigs containing the opsin. Blast clustering can be uncertain because of diminishing percent identity or even loss of these flanking genes; common chromosomal displacements such as inversions eventually disrupt most syntentic arrangements.

The fasta header of each sequence serves as a miniature database that conveniently collects this and other basic information, with fields showing the opsin type, genus, species and common name, accession number, best PubMed citation, indels, intron pattern, sequence length, lambda max adsorption, flanking synteny, and G protein type with which it interacts (all subject to availability and work-in-progress). These fasta headers by themselves provide a quick over view the opsin reference set collection -- simply paste into a blank document and pull lines containing '>'.

Thus the usual querying at GenBank does not remotely compare to the Opsin Classifier. Those sequences -- often mis-annotated by an unattended pipeline or well-intentioned individual with no qualifications in comparative genomics -- are spread out over separate databases not accessible by any single method, with difficult-to-interpret edge creep of genomic blast matches, uncorrected frameshifts, missing stop codons and erroneous amino terminals.

As worst-case scenario, half-baked annotation of the sea urchin genome by pipelines and casual procedures has left a awful legacy of bogus opsin gene structures at GenBank, journal alignments, and genome browsers -- often mis-classified because of an inadequate set of reference sequences and non-opsin GPCR controls, chimeric confusion in tandem duplicates, and non-consideration of intron structure, indels, and synteny. These errors may ripple downstream to errors by subsequent scientists trusting GenBank nr as classifier and lead to a whole subculture taken up with non-existent "virtual" opsins and attendant vacuous speculation on echinoderm photoreception.

Melanopsins, the unexpected rhabdomeric-class Gq-coupled opsin recently found in upper deuterostomes, illustrate some of the difficulties of accurate annotation. They can be confused homologically due to various expansions and contractions. Mammals, human through platypus, have a single melanopsin. However a common ancestor to chicken, lizard, frog, teleost fish, and possibly cartilaginous fish had a multi-gene segmental duplication with both resulting melanopsins retained (though substantially diverged). In ray-finned fish, a processed retrogene arose that may be functional in zebrafish though lost in fugu and stickleback. After whole genome duplication, zebrafish also retained two copies of the original melanopsin. Chondrichthyes also have a second copy of the primary melanopsin but synteny -- which is essential for analysis since intron placement is uninformative in duplications and sequence alignment too dependent on unknown rates -- is not available in the current contig-level assembly.

Amphioxus contains two melanopsins from an apparently independent duplication. Flanking gene order today bears no relation to any vertebrate gene order. The lamprey situation awaits assembly of its traces or targeted transcript studies. At this time, only a four-exon fragmentary melanopsin can be recovered (however with high percent identity, 80%). Possibly orthologs of this melanopsin locus could be tracked into the highly derived tunicates, acorn worm, and sea urchins. The distinctive intron pattern may even allow melanopsin antecedents to be identified in Cnidaria and Protostomia. At this point, the best blastp match to insects stands at 37% with no evident syntenic or intronic support.

While clade-specific proliferations of melanopsins -- and implied role subfunctionalizations -- confounds the situation for chordates, it has little impact on the opsin classifier described here. Unknown sequences readily find their place because of the extensive phylogenetic representation of reference sequence orthology classes and the inherent distance of melanopsins from the ciliary sub-collection. At that level of alignment, the melanopsins serve as outgroup to ciliary opsins and so help define motifs specific to Gt-coupled signaling and other structure/function issues.

It appears however that far too much 'lumping' has taken place in nearly all non-imaging opsins, for example encephalopsins, melanopsins, and peropsins. The taxonomic counterpart is too much lumping of species outside of mammal. In all likelihood, additional opsin orthology classes need definition and distinctive naming. These opsins were belatedly discovered through whole-genome homology searches; they may differ one from another just as much as cone and rod opsins. However, it is currently difficult to disentangle phylogenetically short-lived expansions within known families from deep-rooted parallel-evolving subfamilies concentrated (superficially) within 'secondary' photoreception systems. Genome sampling density and completion efforts are overwhelmingly concentrated in a few model species and near human.

We should not be too hasty to write off peropsins as mere auxiliary retinal isomerases that replenish cis-retinal for 'real' opsins. This reaction is not a simple isomerization (like glucose isomerase) but photoisomerization with an evolutionarily tuned and conserved visual light action spectrum. There is no reason that trans-retinal cannot be the signaling agonist with conversion to all-cis retinal the waste product. Pairing two opposing types of opsins in a single cell or nearby cells then completes a full visual cycle with interesting opportunities for sensory capabilities. Of all the so-called retinal isomerases, peropsins retain more of the diagnostic residues of ciliary opsins; possibly they function similarly but in balance with another opsin class co-expressed in the same cell. Melanopsin, surprisingly, is fully capable of self-replenishment, so perhaps the first-studied ciliary opsins are the true anomaly with their need for an auxiliary replenishment cycle in the retinal epithelium.

It's abundantly clear from distinct ancestral introns and alignment clustering that peropsins together with neuropsins and RGR opsins comprise a distinctive subclade within the overall opsin gene tree. The comparative genomics of RGR illustrates the danger of phylogenetic under-sampling: with much deeper sampling, we can observe that the E/DRY motif -- conserved across all classes of opsins (indeed GPCR) and critical to maintaining non-signaling conformation -- has become GRY in all boreoeutheran mammals (it's ERY in afrotheres, lost without residual debris in marsupials, and DRY from platypus through shark and even tunicate, and DRY in neuropsins and peropsins).

In other words, after several trillion years of branch length conservation as charged amino acid, a radical amino acid substitution has taken hold -- to glycine with its tiny non-interactive side chain. Yet this subclade of placental mammals, this glycine has been conserved without exception for over two billion years of branch length. Given the importance of this motif for maintaining the non-signaling state, this suggests a major change in functional properties of RGR opsins within boreoeutheres, a change that does not tolerate a reduced alphabet at this site. That change might be breakdown to non-signaling isomerase within that clade. It remains unclear how marsupials cope without the gene at all or how Afrothera and Xenarthra visual cycles differ from other placental mammals.

Comparative Genomics of DRY motifs in exon 3 of RGR Opsins:
1 RWPYGSDGCQAHGFQGFVTALASICSSAAIAWGRYHHYCT 1 human
1 RWPYGSDGCQAHGFQGFVTALASICSSAAIAWGRYHHYCT 1 macaque
1 RWPYGSGGCQAHGFQGFTTALASICGSAAIAWGRYHHYCT 1 lemur
1 RWPYGSDGCKVHGFQGFATALASISGSAAIAWGRYHQYCT 1 treeshrew
1 RWPHGSEGCQVHGFQGFATALASICGSAAVAWGRYHHYCT 1 mouse
1 RWPYGSDGCQAHGFQGFATALASICGSAAIAWGRYHHYCT 1 rabbit
1 RWPYGSDGCQAHGFQGFATALASICGSAAIAWGRYHHYCT 1 pika
1 RWPYGSEGCQAHGFQGFVTALASICSSAAVAWGRYHHFCT 1 cow
1 RWPYGSDGCQAHGFQGFVTALASICSSAAIAWGRYHHYCT 1 horse
1 RWPYGSNGCQAHGFQGFVTALASICSSAAIAWGRYHHYCS 1 cat
1 RWPYGPDGCQAHGFQGFATALASICSSAALAWGRYHHYCT 1 dog
1 RWPYGSGGCQAHGFQGFAAALASICGSAAVAWGRYHHYCT 1 bat
1 RWPFGPDGCQAHGFQGFATALASICSSAAIAWGRYHHYCT 1 shrew
1 RWPYGSDGCQAHGFQGFVTALASICSCAAIAWERYHHYCT 1 elephant
1 RWPYGSDGCQAHGFQGFVMALTSICSCAAIAWERYHHYCT 1 hyrax
1 HWPYGSGGCQAHGFQGFTVALASICSCAAIAWERYHHYCT 1 tenrec
1 RWPHGSDSCQAHSFQGFATALASISSSAAIAWERYRHHCT 1 sloth
1 RWPYGSGGCQAHGFQGFVTALASISSSAAIAWERCHRHCI 1 armadillo
1 HWPYGAEGCRLHGFQGFATALASISLSAAIGWDRYLRHCS 1 platypus
1 YWPYGSDGCQIHGFHGFLTALTSISSAAAVAWDRHHQYCT 1 lizard
1 YWPYGSEGCQIHGFQGFLTALASISSSAAVAWDRYHHYCT 1 chicken
1 YWPYGSEGCQIHGFQGFVAALSSIGSCAAIAWDRYHQYCT 1 frog
1 YWPYGSDGCQTHGFQGFVTALASIHFIAAIAWDRYHQYCT 1 stickleback
1 YWPYGSDGCQTHGFQGFMTALASIHFIAAIAWDRYHQYCT 1 zfish1
1 HWPFGSEGCQLHAFQGMVSILAAISFLGAVAWDRYHQYCT 1 zfish2
1 YWPYGSEGCQTHGFQGFVTALASIHFVAAIAWDRYHQYCT 1 tetraodon
1 YWPYGSDGCQTHGFQGFVTALASIHFVAAIAWDRYHQYCT 1 fugu
1 YWPYGSEGCQTHGFHGFLTALASIHFIAAIAWDRYHQYCT 1 medaka
1 YWPYGSDGCQTHGFQGFMTALASIHFIAAIAWDRYHQYCT 1 pimephales
1 YWPYGSDGCQTHGFQGFMTALASIHFVAAIAWDRYHQYCT 1 osmerus
1 YWPYGSEGCQTHGFHGFLMALASINACAAIAWDRYHQNCS 1 elephantshark
1 EWPFGSIGCQLDAFIGMAPTFISIAGAALVAKDKYYRICK 1 tunicate 1
1 RWLFGKFGCYFHGFAGMLFGLGSIGNLTVISIDRYIITCK 1 tunicate 2
1 QWPFGDLGCQVDAFIGMAPTFISIAGAALIAKDKYYRFCK 1 tunicate 2

Excellent recent publications have greatly added to our understanding of the evolutionary origin of light reception capabilities, yet only with the advent of genomic sequencing have we begun to get a full grip on opsins and a few other evo-devo photoreceptor components such as PAX6. Yet critical early-diverging metazoan genomes that might retain information on ancestral characters are greatly under-represented given the branch lengths involved. No purpose is served by elaborate gene tree computations that include a single token peropsin or parietopsin among hundreds of cone opsins; if opsins are central to the endeavor yet so haphazardly annotated, what is the status of dozens of lesser but still critical photoreceptor gene families?

The question of how many times eyes independently arose is ill-posed. We can only wonder how people with no grasp whatsoever of the underlying molecular biology of photoreception could pontificate so boldly on its evolution prior to even sequencing of the first opsin in 1980. First collect comprehensive comparative genomic data sets on all the components in all the relevant clades; then ask what it could mean to homologenize two contemporary systems comprised of partially overlapping sets of heterogeneous paralogs from assorted ancient gene families having long complex histories of clade-specific expansion and contraction cycles. If four arrestins serve a thousand GPCR, if even specialized photoreceptor cells express dozens of barely related 7TM signaling molecules, it's difficult to imagine what a cognate arrestin or ectopic evo-devo cassette might be. It's difficult enough to reconstruct an ancestral gene or two; reconstructing ancestral systems biology interactions lies in the future.

After reviewing topics such as ciliary opsin in protostomes, rhabdomeric opsins in deuterostomes,the rich opsin repertoires in cnidarians and probable opsins in sponges, we will consider special topics such as the origin of image-forming eyes between amphioxus and lamprey divergences, noting throughout that our notion of 'eye' is much more nuanced than earlier. The reconstruction of Ur-bilateran and Urmetazoan eyes awaits additional cnidarian genomes but no new ones are currently underway. However the plethora of new arthropod and lophotrochozoan genome assemblies has opened up new avenues of research as the realization grows that fly and nematode model species are exceedingly derived, with better ancestral characters retained in other lineages.

Numerous conflicting gene trees have been published for ciliary opsins. Some methodologies have bordered on the preposterous -- thin phylogenetic coverage, dimly related outgroups such as adrenergic receptors, and naive underlying mutational models assumed for maximal likelihood despite great diversity of species and many billions of years of branch length. Nonetheless the resultant trees have only moderate conflict, suggesting that a definitive opsin gene tree is not far off. We'll do this using the multiple types of evidence discussed above.

The first point to be understood in deuterostome ciliary opsin evolution is jawless fish such as lamprey already exhibit a full-blown set of modern rod and cone opsins whereas earlier diverging clades as represented by hemichordate, echinoderm, amphioxus and tunicate genomes totally lack them and indeed lack imaging eyes altogether, while using their rhabdomeric opsins in a very distinct signaling system for their own photoreception systems. Despite 7 sequenced opsin mRNAs in the amphioxus Branchiostoma belcheri and an initial assembly in Branchiostoma floridae providing counterparts there, no rod/cone opsin can be located there or in earlier diverging deuterostomes with genome projects (3 tunicates, 2 urchins, 1 acorn worm). These species may have larval eye spots, ocelli, pigment cells, and related photoreceptors but lack imaging eyes.

Characters in extant (living) species should never be confused with ancestral characters present at the time of divergence nodes (last common ancestors); conceivably these early diverging deuterostomes have lost opsin genes, perhaps due to a habitat shift to deep water, burrowing habitat, or nocturnal lifestyle. However the molecular evidence is quite clear that full-blown pentachromatic color vision and most other modern ciliary opsin classes first appeared during the evolutionary stem preceding lamprey divergence. These are demonstrably not 'new' genes but derived from gene duplication and divergence of still older opsins of ciliary class..

The fossil record is unsatisfactory: less than 1 bilateran in 10,000 in Chengjiang and Burgess Shale fossils is even a candidate for deuterostomy. Low numbers of specimens and poor preservation conspire with career pressures and impact-seeking journals in egregiously misinterpreted data in the view of Hou, discoverer of the Chinese lagerstaette. Myllokunmingia is the best situation with 500 specimens; however Haikouichthys as supposed stem deuterostome, Metaspreggina as supposed post-Ediacaran, and Yunnanozoan generally are problematic, valid only in the eye of some beholder.

While signs of bilaterally disposed eyes are sometimes documentable, it does not follow these were image-forming eyes. Indeed contemporary Branchiostoma and tunicate larva have an eye-spot (ocellus); the genomes contain ciliary opsins but only clustering to ENCEPH and PPIN -- still a long ways from any imaging opsin. Echinoderms and hemichordates genomes also have opsins but even further diverged. Sea urchin genome encodes at least six opsins, four of these cluster classify to rhabdomeric, ciliary and Go-type. Tube feet are apparently the photosensory organ in adult urchins.

The oldest known fossil lamprey, Priscomyzon, dates at 360 myr to the Devonian. Molecular clocks place lamprey appearance at approximately 430 myr, some 100 million years after Chengjiang and Burgess Shales fossil Lagerstaette formed. Like most soft tissues, eyes seldom leave a good fossil record, though bilateral placement might be reflected in bone orbits. Hagfish, sister group to lamprey, have imaging eyes but have not been studied; their opsins situation may be derived due to deepwater marine habitat (similarly deepwater coelacanth opsins are adapted to less scattered wavelengths, centered at420 nm).

The next-diverging chondrichthyes have inadequate data at GenBank -- only a few rhodopsin genes from skates and dogfish. This makes even fragmentary opsins from the partially sequenced elephantfish Callorhyncus milii quite valuable. Those 9 fragments and 3 from the lamprey genome are provided in the data section -- the opsin classifier tool can reliably type a fragment from a single mid-sized exon. Full length genes are preferable but these fragments serve to prove existence of various gene class at the time of a given divergence node. Further, they can validate certain rare genomic events provided the fragment happens to overlap the region of interest.

On the other hand, thousands of high-quality Cambrian arthropod fossils unmistakably show stalked paired eyes. Fossil trilobite eyes have been much studied; these are better preserved due to calcite as lens crystalin. Imaging eyes of contemporary arthropods and lophotrochozoa are rhabdomeric, utilizing depolarizing Gq-type receptor, phospholipase C, phosphoinositol, diacylglycerol, and transient receptor potential TRP and TRPL channel signaling. However their genomes can also contain ciliary opsins, using hyperpolarizing Gt-type transducins and phosphodiesterase cGMP second-messaging (as well as Go-type gustducin ciliary opsins in other types of photoreceptors).

Vertebrates are just the opposite, having crossed over to a near-exclusively ciliary opsin-based imaging system, while retaining rhabdomeric signaling in retinal ganglion cells and elsewhere. (A very recent report demonstrates very rare human and mouse cone cells expressing exclusively melanopsin; however melanopsin cannot have given rise to ciliary cone opsins.)

It must not be thought that bilaterans invented imaging eyes because much earlier diverging cubomedusan jellyfish such as Carybdea marsupialis has 4 eyestalks each with 6 photoreceptors of 4 types: simple eyespots, pigment cups, complex pigment cups with lenses, and camera-type eyes with a cornea, lens, and retina. This jellyfish chases, captures, and eats 'more advanced' teleost fish. This wing of cnidarians very much needs a genome project.

Cnidarian opsins are becoming available from Hydra and Nematostella genomes and targeted hybridization experiments. Hydra may express a ciliary-type opsin in ectodermal sensory nerve cells whereas Nematostella has opsins classifying between melanopsin and encephalopsin. These distant opsin are very difficult to distinguish bioinformatically from non-opsins in the rhodopsin superfamily within GPCR, so it is exceedingly important to include controls because a somewhat unspecialized photoreceptor cell may also express other sensory system signaling non-opsins that are nonetheless genetically homologous.

In summary, there is no evidence whatsoever -- and every reason to doubt from genomic analysis -- that deuterostomes had imaging eyes during the Cambrian. Despite this, a BBC series "Walking With Monsters" portrayed a school of 25 mm Haikouichthys attacking and wounding an Anomalocaris twenty times their size. It is easy to guess at a scientific advisory panel that envisions deuterostomes triumphing over protostomes. This recurrent anthropocentric fantasy is echoed in museum imagery of early mammals nimbly predating on dinosaur nests -- dioramas quietly dismantled after Yucatan meteorite discovery.

Imaging eyes are not essential to survival; even today subterranean mammals such as blind mole rat flourish without them. Discounting ray-finned fish numbers, a very substantial proportion of all extant animal species lack imaging eyes 525 myr after the Cambrian. Of 33 animal phyla, one-third have no specialized organ for detecting light, one-third have light-sensitive organs, and the remaining 6 have imaging eyes (Cnidaria, Mollusca, Annelida, Onychophora, Arthropoda, and Chordata). Thus 82% of animal phyla have survived well over 500 myr without imaging eyes despite the supposedly unrelenting competition/predation from animals having them.


Opsin Gene and Species Trees

The phylogenetic tree below shows the presence or absence of various opsin genes in clade-representative species, as reflected in the collected reference sequences. The purpose is timing appearance (or disappearance) of a given class of opsin gene. For example, cone and rod opsins first appeared before lamprey divergence; otherwise they are absent from urochordates, cephalochordates, and earlier deuterostomes. Note however a given gene might appear absent because of a genome project gap, lack of experimental effort, insufficient or outdated bioinformatics, or species choice (ie present in a different representative of that clade). In other cases (eg platypus SWS1) pseudogene remnants or a syntenically proven deletion establish a gene as definitely absent.

TMTsurvivors.png

      Opsin retention at 18 genetic loci over 540 million years (Jan 2009 update)
 
 1 RHO1   petMar calMil takRub xenTro galGal anoCar ornAna monDom bosTau homSap RHO1
 2 RHO2   geoAus calMil danRer ...... galGal anoCar ...... ...... ...... ...... RHO2
 3 SWS1   geoAus ...... danRer xenLae galGal anoCar :::::: monDom bosTau homSap SWS1
 4 SWS2   geoAus ...... gasAcu xenTro galGal anoCar ornAna ...... ...... ...... SWS2
 5 LWS    petMar calMil danRer xenTro galGal anoCar ornAna monDom bosTau homSap LWS
 6 VAOP   petMar calMil danRer xenTro galGal anoCar ...... ...... ...... ...... VAOP
 7 PIN    ------ calMil ...... xenTro galGal utaSta...... ...... ...... ...... PIN
 8 PPIN   petMar calMil danRer xenTro ...... anoCar ...... ...... ...... ...... PPIN
 9 PARIE  petMar ------ danRer xenTro ...... anoCar ...... ...... ...... ...... PARIE
10 ENCEPH petMar calMil danRer xenTro galGal anoCar ...... monDom :::::: homSap ENCEPH
11 TMT    ------ calMil danRer xenTro galGal anoCar ornAna monDom ...... ...... TMT
12 MEL1   petMar calMil danRer xenTro galGal anoCar ornAna monDom bosTau homSap MEL1
13 MEL2   ------ calMil danRer xenLae galGal anoCar ...... ...... ...... ...... MEL2
14 NEUR1  petMar calMil danRer xenTro galGal anoCar ornAna monDom bosTau homSap NEUR1
15 NEUR2  ------ calMil danRer xenTro galGal anoCar ...... ...... ...... ...... NEUR2
16 NEUR3  petMar calMil danRer xenTro galGal anoCar ...... ...... ...... ...... NEUR3
17 PER    ------ calMil danRer xenTro galGal anoCar ornAna monDom bosTau homSap PER
18 RGR    petMar calMil danRer xenTro galGal anoCar ornAna ...... bosTau homSap RGR
          1  3     15     17     17     16     18     7       8      7     8
 
 Notes: in low coverage genomes, missing data was sought in closely related species.
 Absence of data (---) is distinguished from strong evidence of absence (...). 
 In rare cases, pseudogene debris is still detectable at syntenic location (:::)
 Gene loss is a mixture of deep stem loss (mammals) and recent lineage-specific loss.

The opsin gene trees below illustrate only a few of the myriad possibilities, even beginning with commonsense ordering (blast nearest neighbors). Because these gene families originated long ago and are only known from remotely related representatives in extant species with wildly differently mutational mechanisms and histories, the true tree cannot be reliably inferred from maximal likelihood. Indeed no two such attempts have ever come up with the same gene tree! Instead, we'll keep this set of gene trees in view until analysis of rare genomic events is completed

Opsin gene trees.png


Using the Opsin Classifier

Below is the primary collection of opsin protein sequences. Here "fields" in the fasta header show gene name, genus, species, common name, heterotrimeric G protein alpha subunit used in signaling, intron structure, synteny (2 flanking genes on each side of the opsin), indel status, sequence length, lambda max, and comment field. The 230-odd sequences are now organized into deuterostomes, lophotrochozoans, and ecdysozoan divisions, further broken refined into ciliary, rhabdomeric, or neither. Even with the full set copied into the uBlast, a novel opsin candidate can be classified in 6 seconds over just a conventional DSL internet connection.

On 26 Nov 07, I added 41 new sequences, mostly arthropod rhabdomeric imaging opsins, extracting them from a 2007 pancrustacean opsin paper, using the much-studied accessions in their Table 1, as ordered phylogenetically according to their Fig.3, with subsampling to avoid too-close sequences and narrow lineage-specific expansions. This involved replacing a few defective accessions and partial sequences with comparable complete ones, favoring sequences with completed or planned genome projects which can be directly intronated and their synteny determined. Lambda max values were helpfully compiled for all these opsins by the original authors.

This significantly upgrades the resolving power of the Opsin Classifier vis-a-vis these new classes of protostome opsins. It raises thorny nomenclature issues because of short-sighted historic uses such as rhodopsin or LWS for both fruitfly and human genes. These are indeed vaguely homologous in the distant pre-Bilateran GPCR past but are certainly not orthologous as implied by the same common name. The definition of orthology requires genes under comparison in extant species to descend from a single parent gene in their last common ancestor. If this LCA requirement is relaxed, the entire set of a thousand GPCR all become orthologous.

Additional ecdysozoan and lophotrochozoan opsins are needed, whatever new that can be extracted from invertebrate genome projects; some of these will prove ciliary and conversely some deuterostome opsins rhabdomeric. Melanopsin/encephalopsin appear at the heart of the Big Switchover that took place in chordates -- their imaging opsins did not arise from gene duplication and divergence of anything we see among contemporary protostomal imaging opsins or any reconstructed ancestor.

In fact, none of the opsin genes in Ur-bilatera destined to become rhabdomeric imaging opsins in living arthropods (even all of protostomia) seems to have descended directly to any deuterostome. It may turn out that none of the opsin genes in Ur-Bilatera destined to become ciliary imaging opsins in living vertebrates (even all of Deuterostomia) survived in any protostome. The pool of GPCR genes was already large and signaling diversified across gene copies. However lophotrochozoa and basal ecdysozoan ciliary opsins are still largely unexplored. A similarly 'bad' Venn diagram could hold in Ur-eumetazoa. Here the only two cnidarians with sequence data (Hydra and Nematostella) were not the best choices for studying opsin evolution. We may have to wait for genome sequencing of a full-featured cubomedusan.

Please do not add text or edit sequences at this time, even though genomeWiki encourages participation; consider starting a fresh page to hold your contributions. After finishing the first round of articles, everything will be revisited and reorganized at a second pass.

Curated opsin reference sequences

The 460 manually curated opsin sequences below provides an optimal set for phylogenetic research in opsin evolution. These sequences have been collected from over 75 metazoan genome projects in addition to those extracted comprehensively from GenBank. Errors in genome assembly, flawed or missing annotation and mistakes in gene models have largely been corrected by advanced bioinformatic methods. (GenBank data cannot be used as it stands.) An opsin sequences is included only if it provides more information than clutter -- gene expansions limited to narrow clades and over-sampled loci are restricted to proxy representatives.

However eight opsin genetic loci -- some new -- have greatly expanded reference sequence collections within separate articles. These explore more fine-grained opsin evolution restricted to the 48 vertebrate genomes available on 10 Jan 2010. Data from complete genomes offers four advantages over transcripts, namely it can provide regulatory regions, introns, flanking gene synteny, and exhaustive opsin paralog sets present in the organism.

The fasta header lines below are structured as a flatfile database. Fields are separated by spaces rather than tabs (which display poorly). The first field (all that will be retained by most web alignment tools) gives the gene name together with a 3+3 genus-species latin name code.

These gene names mostly comply with international conventions and historic first-use but do not perpetuate poor terminology (use of already-assigned gene names, obtuse acronyms, greek letters, roman numerals, hyphens, subscripts, calling everything rhodopsin and so forth). Paralog subfamilies are numbered sequentially; recent gene duplicates (limited in phylogenetic distribution) are distinguished by lower case letters with different letters denoting those demonstrably arising from whole genome duplications. The nomenclature closely follows the opsin gene tree, indeed implicitly provides it (other than deep branching).

Each major branch of the metazoan opsin gene tree is assigned a distinct short gene name that evokes its common name without need for explanatory table. Some names require periodic revision as more information emerges on their phylogenetic origin. While a later field of the fasta header does supply synonomy, should any confusion over sequence nomenclature ever arise, it is best resolved by text query of a sequence snippet using web browser search capability.

The next three fields provide the full genus and species names (per GenBank taxonomy) and then a one-word common name. The latter can provide helpful orientation when the genus/species is unfamiliar. Next comes a field providing three units of higher order taxonomic nomenclature that allow phylogenetic subsetting of the database. For example chicken receives Deut.Saur.Arch as a deuterostome, sauropod like lizard, but archeosaur like finch but unlike lizard. This field implicitly places all the sequences on a phylogenetic tree. It assumes, unlike GenBank, that ecdysozoa and lophotrochozoa are the correct partition of protostomes.

The next two fields provide a GenBank accession and PubMed identifier if any exist. The reference sequences here do not follow GenBank when it errs (as it often does, eg by retaining introns, omitting exons, extending the 'first' exon to a false initiating methionine, extending the 'final' exon to a false stop codon, leapfrogging across tandem genes to form chimeric genes). Many uncurated gene models are poor quality. However even these entries can provide historic credits and supplement the protein entries below with underlying dna.

The PubMed identifier links to a recent journal article with substantive experimental data specifically relevant to the opsin sequence at hand. Such papers review earlier literature and most hubs also provide subsequent papers citing the initial paper. This allows rapid collection of all work pertaining to a given opsin gene. Papers are not cited that simply sequenced tens of thousands of transcripts without characterization or comment on fortuitously included opsins.

The next field provides a measure of sequence completeness. About 1 sequence in 7 is fragmentary (but often not affecting the 7-transmembrane core). While important in proving that a given orthology class exists in a given clade (as are recent pseudogenes) and helpful in defining conserved residues in local alignments, these sequences cannot currently be completed. Reasons include too-rapid divergence of non-membrane regions, gaps in assembly coverage of individual exons, uncertainty in exon boundaries, and incomplete transcripts.

GabgComplexity.jpg

The following field suggests a Galpha signaling partner for each opsin, important to understanding both structure and function. This is more wish-list than established fact because the rare cases known from direct experimental work have merely been extended below using homology to not-too-divergent orthologs in fairly closely related species -- even though the reliability of this procedure remains untested.

Indeed, the opsin literature is confused over what this classification should even mean, the options being (1) the specific Galpha gene product(s) physically docking to the cytoplasmic face of the opsin, (2) merely a gene tree subclade (eg Gs) of interacting Galpha protein whatever that might mean within a complicated gene duplication tree itself scarcely comparable over metazoa and already inadequate to resolve rod and cone GNAT transducins, (3) the small molecule produced that does the actual signaling (eg cyclic nucleotide or phosphoinositol), or (4) the character of downstream signaling ultimately produced (eg inhibitory).

Here the issue revolves around what is experimentally measurable -- opsins are not tested in a biochemically defined reconstituted system against individual Galpha proteins purified from the cognate species but rather signaling is characterized indirectly via the effect of some inhibitor or output of small molecule. While it appears that all opsin loci retain the universal features of GPCR signaling, it hasn't actually been established that all do in fact signal (rather than just serve as non-signaling photoisomerases in intermediary metabolism of retinoids).

The next fields provide syntenic gene order (when known and relevant to a research issue), alternative gene names, tissues of expression, percent identity to nearest neighbor, and unstructured miscellaneous comments. Lambda-max peak adsorption could be added though it has been measured by a mix of techniques and is not necessarily reliably calculated from classical tuning residues in less-familiar opsin classes. Length in amino acids is no longer provided because it does not satisfactorily explain fragmentary entries nor the run-on amino and carboxy termini in some opsin classes.

Adherence to rigid database format drops off after the early fields because the information is just not available or predictable for many entries. However the structure still suffices for routine queries such as 'how many opsins do tunicates have' or 'which protostomes have ciliary opsins'. Note the fasta header lines are easily isolated by pasting the entire database (including sequence lines) into a spreadsheet and sorting to collect lines beginning with '>'. The fields can be separated cleanly into columns by replacing spaces with tabs.

The protein sequences themselves are broken into their constituent exons. The numbering indicates phase (ie basepair overhang), a deeply conserved invariant useful in distinguishing orthology classes and gene tree divisions. All opsins in all species use standard GT-AG splice junctions. Alternate splicing within the core protein may occur but never produces functional protein. The exon structures in genomic species have been determined individually by tblastn and those of non-genomic species predicted by homology.

Full length genes beginning with an initial methionine and ending with a stop codon are the most useful. However the initial methionine cannot always be disambiguated, a problem not restricted to opsins. In run-on genes lacking 3' transcripts, the stop codon is taken as the first encountered in extending the last homologically reliable exon; however the true stop codon could lie in a different reading frame (ie in a cryptic terminal exon).

Fragmentary genes are included if the species occupies a critical position in the phylogenetic tree (eg lamprey) and the fragment is long enough to reliably classify it. Fragmentary data often takes the form of entire exons missing from genomic coverage (rather than incomplete exons). When these exons lie in unconnected contigs, their combination into a single gene is not entirely reliable.

For example the Callorhinchus genome project, currently with 0.6 exon coverage, still suffices to establish that many gene duplications important to vertebrate photoreceptive diversity had already occurred by the chondrichthyian divergence node. However without transcripts, a lineage-specific duplication in LWS might have result in a single chimeric gene assembled from scattered individual LWS exons.

Fragmentary genes for isolated fast-evolving invertebrates are difficult to distinguish from non-opsin GPCR which share many motifs such as DRY. To balance the need for maximal phylogenetic coverage against the imperative of not contaminating the opsin reference collection with non-opsin GPCR, partial genes are required to contain the K296 Schiff base and other diagnostic residues and motifs specific to opsins.

>RHO1_bosTau Bos taurus (cow) Deut.Euth.Laur NM_001014890 2145276 full Gt RH1 RHO rhodopsin rod opsin syn(-MBD4 +IFT122 +H1FOO -PLXND1)
0 MNGTEGPNFYVPFSNKTGVVRSPFEAPQYYLAEPWQFSMLAAYMFLLIMLGFPINFLTLYVTVQHKKLRTPLNYILLNLAVADLFMVFGGFTTTLYTSLHGYFVFGPTGCNLEGFFATLG 1
2 GEIALWSLVVLAIERYVVVCKPMSNFRFGENHAIMGVAFTWVMALACAAPPLVGWSR 2
1 YIPEGMQCSCGIDYYTPHEETNNESFVIYMFVVHFIIPLIVIFFCYGQLVFTVKE 0
0 AAAQQQESATTQKAEKEVTRMVIIMVIAFLICWLPYAGVAFYIFTHQGSDFGPIFMTIPAFFAKTSAVYNPVIYIMMNKQ 0
0 FRNCMVTTLCCGKNPLGDDEASTTVSKTETSQVAPA* 0

>RHO1_homSap Homo sapiens (human) Deut.Euth.Euar NM_000539 16565402 full Gt RH1 RHO rhodopsin rod opsin syn(-MBD4 +IFT122 +H1FOO -PLXND1)
0 MNGTEGPNFYVPFSNATGVVRSPFEYPQYYLAEPWQFSMLAAYMFLLIVLGFPINFLTLYVTVQHKKLRTPLNYILLNLAVADLFMVLGGFTSTLYTSLHGYFVFGPTGCNLEGFFATLG 1
2 GEIALWSLVVLAIERYVVVCKPMSNFRFGENHAIMGVAFTWVMALACAAPPLAGWSR 2
1 YIPEGLQCSCGIDYYTLKPEVNNESFVIYMFVVHFTIPMIIIFFCYGQLVFTVKE 0
0 AAAQQQESATTQKAEKEVTRMVIIMVIAFLICWVPYASVAFYIFTHQGSNFGPIFMTIPAFFAKSAAIYNPVIYIMMNKQ 0
0 FRNCMLTTICCGKNPLGDDEASATVSKTETSQVAPA* 0

>RHO1_monDom Monodelphis domesticus (opossum) Deut.Meta.Dide genomic full Gt RH1 RHO rhodopsin rod opsin syn(-MBD4 +IFT122 +H1FOO -PLXND1)
0 MNGTEGPNFYVPFSNKTGTVRSPFEEPQYYLADPWQFSCLAAYMFMLIVLGFPINFLTLYVTIQHKKLRTPLNYILLNLAIADLFMVFGGFTMTLYTSLHGYFVFGPTGCNLEGFFATLG 1
2 GEIALWSLVVLAIERYVVVCKPMSNFRFGENHAIIGVAFTWVMALACAFPPLIGWSR 2
1 YIPEGMQCSCGIDYYTLKPEVNNESFVIYMFVVHFTIPLIVIFFCYGQLVFTVKE 0
0 AAAQQQESATTQKAEKEVTRMVIIMVIAFLICWLPYAGVAFYIFTHQGSNFGPIFMTIPAFFAKSSSVYNPVIYIMMNKQ 0
0 FRTCMITTLCCGKNPLGDDEASATASKTETSQVAPA* 0

>RHO1_ornAna Ornithorhynchus anatinus (platypus) Deut.Prot.Mono ABN43074 17339011 full Gt RH1 RHO rhodopsin rod opsin syn(+IFT122 - -PLXND1)
0 MNGTEGQDFYIPMSNKTGVVRSPFEYPQYYLAEPWQYSVLAAYMFMLIMLGFPINFLTLYVTIQHKKLRTPLNYILLNLAFANHFMVLGGFTTTLYTSLHGYFVFGPTGCNIEGFFATLG 1
2 GEIALWSLVVLAIERYIVVCKPMSNFRFGENHAIMGVAFTWIMALACALPPLVGWSR 2
1 YIPEGMQCSCGIDYYTLRPEVNNESFVIYMFVVHFTIPMTIIFFCYGRLVFTVKE 0
0 AAAQQQESATTQKAEKEVTRMVIIMVIAFLICWVPYASVAFYIFTHQGSNFGPIFMTVPAFFAKSSAIYNPVIYIMMNKQ 0
0 FRNCMLTTICCGKNPLGDDEASATASKTEQSSVSTSQVSPA* 0

>RHO1_galGal Gallus gallus (chicken) Deut.Saur.Arch NM_205490 1385866 full Gt RH1 RHO rhodopsin rod syn(--MBD4 syn(+IFT122 +H1FOO -PLXND1)
0 MNGTEGQDFYVPMSNKTGVVRSPFEYPQYYLAEPWKFSALAAYMFMLILLGFPVNFLTLYVTIQHKKLRTPLNYILLNLVVADLFMVFGGFTTTMYTSMNGYFVFGVTGCYIEGFFATLG 1
2 GEIALWSLVVLAVERYVVVCKPMSNFRFGENHAIMGVAFSWIMAMACAAPPLFGWSR 2
1 YIPEGMQCSCGIDYYTLKPEINNESFVIYMFVVHFMIPLAVIFFCYGNLVCTVKE 0
0 AAAQQQESATTQKAEKEVTRMVIIMVIAFLICWVPYASVAFYIFTNQGSDFGPIFMTIPAFFAKSSAIYNPVIYIVMNKQ 0
0 FRNCMITTLCCGKNPLGDEDTSAGKTETSSVSTSQVSPA* 0

>RHO1_anoCar Anolis carolinensis (lizard) Deut.Saur.Lepi genomic full Gt RH1 RHO rhodopsin rod opsin syn(-MBD4 +IFT122 - -PLXND1)
0 MNGTEGQNFYVPMSNKTGVVRNPFEYPQYYLADPWQFSALAAYMFLLILLGFPINFLTLFVTIQHKKLRTPLNYILLNLAVANLFMVLMGFTTTMYTSMNGYFIFGTVGCNIEGFFATLG 1
2 GEMGLWSLVVLAVERYVVICKPMSNFRFGETHALIGVSCTWIMALACAGPPLLGWSR 2
1 YIPEGMQCSCGVDYYTPTPEVHNESFVIYMFLVHFVTPLTIIFFCYGRLVCTVKA 0
0 AAAQQQESATTQKAEREVTRMVVIMVISFLVCWVPYASVAFYIFTHQGSDFGPVFMTIPAFFAKSSAIYNPVIYILMNKQ 0
0 FRNCMIMTLCCGKNPLGDEDTSAGTKTETSTVSTSQVSPA* 0

>RHO1_xenTro Xenopus tropicalis (frog) Deut.Amph.Anur genomic full Gt RH1 RHO rhodopsin rod opsin syn(-MBD4 +IFT122 - -PLXND1)
0 MNGTEGPNFYIPMSNKTGVVRSPFDYPQYYLAEPWKYSALAAYMFLLILLGFPINFMTLYVTIQHKKLRTPLNYILLNLVFANHFMVLCGFTVTMYTSMHGYFIFGQTGCYIEGFFATLG 1
2 GEMALWSLVVLAIERYVVVCKPMANFRFGENHAIMGVVFTWIMALSCAAPPLFGWSR 2
1 YIPEGMQCSCGVDYYTLKPEVNNESFVVYMFIVHFTIPLCVIFFCYGRLLCTVKE 0
0 AAAQQQESATTQKAEKEVTRMVVMMVIFFLICWVPYAYVAFYIFTHQGSDFGPVFMTVPAFFAKSSAIYNPVIYIVLNKQ 0
0 FRNCLITTLCCGKNPFGDEEGSSAASSKTEASSVSSSQVSPA* 0

>RHO1_neoFor Neoceratodus forsteri (lungfish) Deut.Sarc.Dipn EF526299 17961206 full Gt RH1 RHO rhodopsin rod opsin
0 MNGTEGPNFYVPMTNKTGVVRSPFEYPQYYLADPWKYSALAAYMFFLILTGFPINFLTLYVTVQHKKLRTPLNYILLNLAVADLFMVFGGFTTTMYTAMNGYFVFGVVGCNLEGFFATFG 1
2 GIIALWCLVVLAIERYIVVCKPISNFRFGENHAIMGVVFTWIMALACAGPPLFGWSR 2
1 YIPEGMQCSCGIDYYTLKPEVNNESFVIYMFIVHFTIPLIIIFFCYGRLMCTVKE 0
0 AAAQQQESATTQKAEKEVTRMVYIMVISYLVCWLPYASVSFYIFTHQGSDFGPVFMTVPAFFAKTASVYNPVIYILMNKQ 0
0 FRNCMITTLCCGKNPFGDEETTSAGTSKTEASSVSSSQVSPA* 0

>RHO1_latCha Latimeria chalumnae (coelacanth) Deut.Sarc.Coel AAD30519 10339578 full Gt RH1 RHO rhodopsin rod opsin
0 MNGTEGPNFYVPMSNKTGVVRNPFEYPQYYLADPWKYSALAAYMFFLILVGFPINFLTLFVTIQHKKLRTPLNYILLDLAVADLCMVFGGFFVTMYSSMNGYFVLGPTGCNIEGFFATLG 1
2 GQVALWALVVLAIERYVVVCKPMSNFRFGENHAIMGVIFTWIMALSCAVPPLFGWSR 2
1 YIPEGMQSSCGVDYYTLKPEVNNESFVIYMFVVHFTIPLIVIFFCYGRLVCTVKD 0
0 AAAQQQESATTQKAEKEVTRMVIVMVISFLVCWVPYASVAAYIFFNQGSEFGPVFMTAPSFFAKSASFYNPVIYILLNKQ 0
0 FRNCMITTLCCGKNPFGDEDATSAAGSSKTEASSVSSSSVSPA* 0

>RHO1_angAng Anguilla anguilla (european_eel) Deut.Acti.Elop L78008 full Gt RH1 RHO rhodopsin rod opsin
0 MNGTEGPNFYIPMSNITGVVRSPFEYPQYYLAEPWAYTILAAYMFTLILLGFPVNFLTLYVTIEHKKLRTPLNYILLNLAVANLFMVFGGFTTTVYTSMHGYFVFGETGCNLEGYFATLG 1
2 GEISLWSLVVLAIERWVVVCKPMSNFRFGENHAIMGLAFTWIMANSCAMPPLFGWSR 2
1 YIPEGMQCSCGVDYYTLKPEVNNESFVIYMFIVHFSVPLTIISFCYGRLVCTVKE 0
0 AAAQQQESETTQRAEREVTRMVVIMVIAFLVCWVPYASVAWYIFTHQGSTFGPVFMTVPSFFAKSSAIYNPLIYICLNSQ 0
0 FRNCMITTLFCGKNPFQEEEGASTTASKTEASSVSSVSPA* 0

>RHO1_conMyr Conger myriaster (conger_eel) Deut.Acti.Elop AB043817 full Gt RH1 RHO rhodopsin rod opsin
0 MNGTEGPNFYIPMSNATGVVRSPFEYPQYYLAEPWAFSALSAYMFFLIIAGFPINFLTLYVTIEHKKLRTPLNYILLNLAVADLFMVFGGFTTTMYTSMHGYFVFGPTGCNIEGFFATLG 1
2 GEIALWCLVVLAIERWMVVCKPVTNFRFGESHAIMGVMVTWTMALACALPPLFGWSR 2
1 YIPEGLQCSCGIDYYTRAPGINNESFVIYMFTCHFSIPLAVISFCYGRLVCTVKE 0
0 AAAQQQESETTQRAEREVTRMVVIMVISFLVCWVPYASVAWYIFTHQGSTFGPIFMTIPSFFAKSSALYNPMIYICMNKQ 0
0 FRHCMITTLCCGKNPFEEEDGASATSSKTEASSVSSSSVSPA* 0

>RHO1_danRer Danio rerio (zebrafish) Deut.Acti.Otoc NM_131212 18597743 full Gt RH1 RHO rhodopsin rod opsin extra-ocular rhodopsin
0 MNGTEGPNFYVPMSNRTGLVRSPFEEPQYYLAEPWQFSLLAAYMLFLILGSFPINALTLYVTVQHKKLRTPLNYILLNLAVADLFMVLGGFTVTLYTALHGYFLLGVTGCNIEGFFATLG 1
2 GEIALWSLVVLAIERYIVVCKPMSTFRFGEKHAIIGVGFTWVMALTCAVPPLLGWSR 2
1 YIPEGMQCSCGIDYYTPKPEVHNTSFVIYMFILHFSIPLLIIFFCYSRLLCTVRA 0
0 AAAQQQESETTQRAEREVTRMVVVMVIAFLVCWVPYASVAWYIFANQGAEFGPVFMTVPAFFAKSAALYNPVIYIMLNRQ 0
0 FRNCMLSTVCCGKNPLAEDESSSAVSSKTQSSVVSSAQVSPA* 0

>RHO1_tetNig Tetraodon nigroviridis (pufferfish) Deut.Acti.Perc genomic full G? RH1 RHO rhodopsin rod opsin
0 MNGTEGPNFYVPMSNKTGVVRSPFEYPQYYLAEPWKYSLVAAYMLFLIVTAFPVNFLTLFVTVKHKKLRTPLNYVLLNLAVADLFMVIGGFTVTLYTALHAYFVLGVTGCNIEGFFATLG 1
2 GEIALWSLVVLAIERYIVVCKPVTNFRFGEKHAIAGLAFTWIMALSCAVPPLLGWSR 2
1 YIPEGMQCSCGIDYYTPKPEIHNTSFVIYMFVLHFCIPLAIIFFCYSRLLCTVRA 0
0 AAALQQESETTQRAEKEVTRMVIVMVISFLVCWVPYASVAWYIFANQGTEFGPVFMTAPAFFAKSAALYNPVIYILLNRQ 0
0 FRNCMITTVCCGKNPFGDDDATTSVSKTQSSSVSTSQVAPA* 0

>RHO1_takRub Takifugu rubripes (fugu) Deut.Acti.Perc AF201472 10692583 full Gt RH1 RHO rhodopsin rod opsin syn(-MBD4 +IFT122 - -PLXND1)
0 MNGTEGPNFYIPMSNKTGVVRSPFEYPQYYLAEPWKYSLVAAYMLFLIITAFPVNFLTLFVTVKHKKLRTPLNYVLLNLAVADLFMVIGGFTVTLYTALHAYFVLGVTGCNIEGFFATLG 1
2 GEIALWSLVVLAVERYIVVCKPMTNFRFGEKHAIAGLVFTWIMALTCATPPLLGWSR 2
1 YIPEGMQCSCGIDYYTPKPEINNTSFVIYMFILHFSIPLAIIFFCYSRLLCTVRA 0
0 AAALQQESETTQRAEKEVTRMVIVMVISFLVCWVPYASVAWYIFANQGTEFGPVFMTAPAFFAKSAALYNPVIYILLNRQ 0
0 FRNCMITTVCCGKNPFGDDDAATTVSKTQSSSVSSSQVAPA* 0

>RHO1_gasAcu Gasterosteus aculeatus (stickleback) Deut.Acti.Perc BT028623 full Gt RH1 RHO rhodopsin rod opsin
0 MNGTEGPYFYVPMMNTTGIVRSPYEYPQYYLVNPAAYAALGAYMFLLILVGFPVNFLTLYVTLEHKKLRTPLNYILLNLAVANLFMVLGGFTTTMYTSMHGYFVLGRLGCNVEGFFATLG 1
2 GEIALWSLVVLAVERWVVVCKLIANFRFGEDHAIMGLALTWVMASACAVPPLVGWSR 2
1 YIPEGMQCSCGVDYYTRAEGFNNESFVIYMFVCHFMIPMIIIFFCYGRLLCAVKEA 0
0 AAAQQESETTQRAEREVSRMVVIMVIAFLVCWVPYASVAWFIFCNQGSEFGPVFMTIPAFFAKSSSVYNPLIYICMNKQ 0
0 FRHCMITTLCCGKNPFEEEEGASSTKTEASSVSTSSVSPA* 0

>RHO1_oryLat Oryzias latipes (medaka) Deut.Acti.Perc AB180742 15964232 full Gt RH1 RHO rhodopsin rod opsin
0 MNGTEGPYFYVPMVNTTGIVRSPYEYPQYYLVNPAAYAALGAYMFFLILVGFPINFLTLYVTLEHKKLRTPLNYILLNLAVADLFMVFGGFTTTMYTSMHGYFVLGRLGCNLEGFFATLG 1
2 GEIGLWSLVVLAIERWVVVCKPISNFRFGENHAIMGLVFTWIMAASCAVPPLVGWSR 2
1 YIPEGMQCSCGVDYYTRAEGFNNESFVVYMFVCHFLIPLIVVFFCYGRLLCAVKEA 0
0 AAAQQESETTQRAEREVTRMVVIMVIGFLVCWLPYASVAWYIFTNQGSEFGPLFMTIPAFFAKSSSIYNPAIYICMNKQ 0
0 FRNCMITTLCCGKNPFEEEEGASTTASKTEASSVSSSSVSPA* 0

>RHO1_leuEri Leucoraja erinacea (skate) Deut.Chon.Elas U81514 9256070 full Gt RH1 RHO rhodopsin rod opsin
0 MNGTEGENFYVPMSNKTGVVRSPFDYPQYYLGEPWMFSALAAYMFFLILTGLPVNFLTLFVTIQHKKLRQPLNYILLNLAVSDLFMVFGGFTTTIITSMNGYFIFGPAGCNFEGFFATLG 1
2 GEVGLWCLVVLAIERYMVVCKPMANFRFGSQHAIIGVVFTWIMALSCAGPPLVGWSR 2
1 YIPEGLQCSCGVDYYTMKPEVNNESFVIYMFVVHFTIPLIVIFFCYGRLVCTVKE 0
0 AAAQQQESESTQRAEREVTRMVIIMVVAFLICWVPYASVAFYIFINQGCDFTPFFMTVPAFFAKSSAVYNPLIYILMNKQ 0
0 FRNCMITTICLGKNPFEEEESTSASASKTEASSVSSSQVAPA* 0

>RHO1_calMil Callorhinchus milii (elephantfish) Deut.Chon.Holo genomic full Gt RH1 RHO rhodopsin rod opsin
0 MNGTEGENFYIPMSNKTGVVRSPFEYPQYYLAEPWQFSILAAYMFFLIITCFPVNFLTLYVTFEHKKLRQPLNFILLNLAVADLFMVFGGFFITVYTSLHGYFVFGVTGCNFEGFFATLG 1
2 GEIGLWSLVVLAIERYVVVCKPMSNFRFGTNHAIMGVAFTWVMALACAVPPLMGWSR 2
1 YIPEGLQCSCGVDYYTLKPEINNESFVIYMFVVHFLIPLIIIFFCYGRLVCTVKE 0
0 AAAQQQESESTQRAEREVTRMVIIMVIFFLICWVPYASVAFFIFTNQGSEFGPIFMAVPAFFAKSSALYNPLIYILLNKQ 0
0 FRNCMITTLCCGKNPFEEDESTSAAASKTEASSVSSSQVSPA* 0

>RHO1_petMar Petromyzon marinus (lamprey) Deut.Agna.Hype genomic full Gt RH1 RHO rhodopsin rod opsin
0 MNGTEGENFYIPFSNKTGLARSPFEYPQYYLAEPWKYSVLAAYMFFLILVGFPVNFLTLFVTVQHKKLRTPLNYILLNLAVANLFMVLFGFTLTMYSSMNGYFVFGPTMCNFEGFFATLG 1
2 GEMSLWSLVVLAIERYIVICKPMGNFRFGSTHAYMGVAFTWFMALSCAAPPLVGWSR 2
1 YLPEGMQCSCGPDYYTLNPNFNNESFVIYMFLVHFIIPFIVIFFCYGRLLCTVKE 0
0 AAAAQQESASTQKAEKEVTRMVVLMVIGFLVCWVPYASVAFYIFTHQGSDFGATFMTVPAFFAKTSALYNPIIYILMNKQ 0
0 FRNCMITTLCCGKNPLGDEDSGASTSKTEVSSVSTSQVSPA* 0

>RHO1_geoAus Geotria australis (lamprey) Deut.Agna.Hype AY366493 17463225 full Gt RhA
0 MNGTEGQNFYIPFSNKTDVARSPFEYPQYYLAEPWKFSALAAYMFFLILVGFPVNFLTLFVTVQHKKLRTPLNYILLNLAVSNLFMILFGFTTTMYTSMNGYFVFGPTMCSIEGFFATLG 1
2 GEVSLWSLVVLAIERYIVICKPMGNFRFGNTHAIMGVALTWVMALSCAAPPLLGWSR 2
1 YLPEGMQCSCGPDYYTMNPTYNNESFVIYMFIVHFTIPFVIIFFSYGRLLCTVKE 0
0 AAAAQQESASTQKAEKEVTRMVVLMVVGFLVCWVPYASVAFYIFTNQGSDFGATFMTLPAFFAKSSALYNPVIYILMNKQ 0
0 FRNCMITTLCCGKNPLGDDDSGASTSKTEVSSVSTSQVAPA* 0

>RHO1_letJap Lethenteron japonicum (lamprey) Deut.Agna.Hype AB116382 15096614 full Gt RH1 RHO rhodopsin rod opsin
0 MNGTEGDNFYVPFSNKTGLARSPYEYPQYYLAEPWKYSALAAYMFFLILVGFPVNFLTLFVTVQHKKLRTPLNYILLNLAMANLFMVLFGFTVTMYTSMNGYFVFGPTMCSIEGFFATLG 1
2 GEVALWSLVVLAIERYIVICKPMGNFRFGNTHAIMGVAFTWIMALACAAPPLVGWSR 2
1 YIPEGMQCSCGPDYYTLNPNFNNESYVVYMFVVHFLVPFVIIFFCYGRLLCTVKE 0
0 AAAAQQESASTQKAEKEVTRMVVLMVIGFLVCWVPYASVAFYIFTHQGSDFGATFMTLPAFFAKSSALYNPVIYILMNKQ 0
0 FRNCMITTLCCGKNPLGDDESGASTSKTEVSSVSTSQVSPA* 0

>RHO2_galGal Gallus gallus (chicken) Deut.Saur.Arch NP_990771 2268324 full Gt syn(-IHPK3 -LEMD2 +RHO2 -GRM4 -NUDT3)
0 MNGTEGINFYVPMSNKTGVVRSPFEYPQYYLAEPWKYRLVCCYIFFLISTGLPINLLTLLVTFKHKKLRQPLNYILVNLAVADLFMACFGFTVTFYTAWNGYFVFGPVGCAVEGFFATLG 1
2 GQVALWSLVVLAIERYIVVCKPMGNFRFSATHAMMGIAFTWVMAFSCAAPPLFGWSR 2
1 YMPEGMQCSCGPDYYTHNPDYHNESYVLYMFVIHFIIPVVVIFFSYGRLICKVRE 0
0 AAAQQQESATTQKAEKEVTRMVILMVLGFMLAWTPYAVVAFWIFTNKGADFTATLMAVPAFFSKSSSLYNPIIYVLMNKQ 0
0 FRNCMITTICCGKNPFGDEDVSSTVSQSKTEVSSVSSSQVSPA* 0

>RHO2_taeGut Taeniopygia guttata (finch) Deut.Saur.Arch NM_001076696 full G?
0 MNGTEGINFYVPMSNKTGVVRSPFEYPQYYLAEPWKYRLVCCYIFFLISTGFPINFLTLLVTFKHKKLRQPLNYILVNLAVADLCMACFGFTVTFYTAWNGYFVFGPIGCAVEGFFATLG 1
2 GQVALWSLVVLAIERYIVICKPMGNFRFSASHALMGIAFTWVMAISCAAPPLFGWSR 2
1 YIPEGMQCSCGPDYYTHNPDFHNESYVLYMFVIHFIIPVVIIFFSYGRLVCKVRE 0
0 AAAQQQESATTQKAEKEVTRMVILMVLGFMLAWTPYAVVAFWIFTNKGADFTATLMAVPAFFSKSSSLYNPIIYVLMNKQ 0
0 FRNCMITTICCGKNPFGDEETSSTVSQSKTEVSSVSSSQVSPA* 0

>RHO2_anoCar Anolis carolinensis (lizard) Deut.Saur.Lepi genomic full Gt syn(-IP6K3 -LEMD2 -MLN +RHO2 -GRM4 -NUDT3)
0 MNGTEGINFYVPLSNKTGLVRSPFEYPQYYLAEPWKYKVVCCYIFFLIFTGLPINILTLLVTFKHKKLRQPLNYILVNLAVADLFMACFGFTVTFYTAWNGYFIFGPIGCAIEGFFATLG 1
2 GQVALWSLVVLAIERYIVVCKPMGNFRFSATHALMGISFTWFMSFSCAAPPLLGWSR 2
1 YIPEGMQCSCGPDYYTLNPDYHNESYVLYMFGVHFVIPVVVIFFSYGRLICKVRE 0
0 AAAQQQESASTQKAEREVTRMVILMVLGFLLAWTPYAMVAFWIFTNKGVDFSATLMSVPAFFSKSSSLYNPIIYVLMNKQ 0
0 FRNCMITTICCGKNPFGDEDVSSSVSQSKTEVSSVSSSQVSPA* 0

>RHO2_gekGek Gekko gekko (gecko) Deut.Saur.Lepi AY024356 11591478 full Gt in pure rod retina
0 MNGTEGINFYVPLSNKTGLVRSPFEYPQYYLADPWKFKVLSFYMFFLIAAGMPLNGLTLFVTFQHKKLRQPLNYILVNLAAANLVTVCCGFTVTFYASWYAYFVFGPIGCAIEGFFATIG 1
2 GQVALWSLVVLAIERYIVICKPMGNFRFSATHAIMGIAFTWFMALACAGPPLFGWSR 2
1 FIPEGMQCSCGPDYYTLNPDFHNESYVIYMFIVHFTVPMVVIFFSYGRLVCKVRE 0
0 AAAQQQESATTQKAEKEVTRMVILMVLGFLLAWTPYAATAIWIFTNRGAAFSVTFMTIPAFFSKSSSIYNPIIYVLLNKQ 0
0 FRNCMVTTICCGKNPFGDEDVSSSVSQSKTEVSSVSSSQVAPA* 0

>RHO2_podSic Podarcis sicula (lizard) Deut.Saur.Lepi AY941829 12887418 full G?
0 MNGTEGINFYVPLSNKTGLVRSPFEYPQYYLAEPWKYKMVCCYIFFLISTGLPINLLTLLVTFKHKKLRQPLNYILVNLAVADLFMACFGFTVTFYTAWNGYFIFGPIGCAIEGFFATLG 1
2 GQVALWSLVVLAIERYIVVCKPMGNFRFSSSHALMGIAFTWVMSLSCACPPLFGWSR 2
1 YIPEGMQCSCGPDYYTLNPDYHNESYVVYMFVIHFVIPVVVIFFSYGRLICKVRE 0
0 AAAQQQESASTQKAEKEVTRMVILMVLGFMLAWTPYAVVAFWIFTNKGADFSATLMSVPAFFSKSSSLYNPIIYVLMNKQ 0
0 FRNCMITTICCGKNPFGDDDVSSTVSQSKTEVSSISSSQVSPA* 0

>RHO2_pheMad Phelsuma madagascariensis (lizard) Deut.Saur.Lepi AF074044 10069370 full G?
0 MNGTEGFNFYVPVSNRTGLVRSPYEYPQYYLAEPWKFKALSLYMFFLILVGLPLNGLTLFVTFQHKKLRQPLNYILVNLAVANLLMVICGFTVTFYTSWYGYFVFGPMGCAFEGFFATIG 1
2 GQVALWSLVVLAIERYIVICKPMGNFRFSSSHAMMGISFTWFMALCCGGPPLFGWSR 2
1 FIPEGMQCSCGPDYYTLNPDFHNESYVIYLFTVHFLTPMIIIFFSYGRLVCKVRE 0
0 AAAQQQESATTQKAEKEVTRMVILMVMGFLVAWTPYATVACWIFNNKGAEFSVTFMTVPAFFSKSSCIYNPIIYVLLNKQ 0
0 FRNCMVTTICCGKNPFGDEDASSSVSQSKTEVSSVSSSQVAPA* 0

>RHO2_neoFor Neoceratodus forsteri (lungfish) Deut.Sarc.Dipn EF526299 17961206 full Gt
0 MNGTEGINFYVPHSNKTGVVRSPFEYPQYYLADPWKYSIVCAYMFFLIITGLPINLLTLVVTFKHKKLRQPLNYILVNLAVADLFMVCFGFTVTFSTAINGYFIFGPRGCAIEGFMATLG 1
2 GEVALWSLVVLAIERYIVVCKPMGNFRFSNNHSIIGIVFTWLAALSCAAPPLFGWSR 2
1 YLPEGMQCSCGPDYYTMNPDYHNESFVIYMFVVHFFIPVIVIFVSYGRLICKVKE 0
0 AAAQQQESASTQKAEREVTRMVILMVIGFMTAWTPYATVAFWIFMNKGAEFGATFMAAPAFFSKSSALYNPIIYVLMNKQ 0
0 FRNCMVTTLCCGKNPFGDDDVSSSVSAGKTEVSSVSSSQVSPA* 0

>RHO2_latCha Latimeria chalumnae (coelacanth) Deut.Sarc.Coel AH007713 10339578 full Gt RH2
0 MNGTEGMNFYVPLSNRTGLVRSPFEYTQYYLAEPWKFSVLCAYMFLLIILGFPINFLTLLVTFKHKKLRQPLNYILVNLAVASLFMVVFGFTVTFYSSLNGYFVLGPMGCAMEGFFATLG 1
2 GQVALWSLVVLAIERYIVVCKPMGNFRFASSHAIMGIAFTWIMALACAAPPLVGWSR 2
1 YIPEGLQCSCGPDYYTLNPDFHNESYVMYLFLVHFLLPIIIIFFTYGRLICKVKE 0
0 AAAQQQESASTQKAEKEVTRMVILMVIGFLTAWVPYASAAFWIFCNRGAEFTATLMTVPAFFSKSSCLFNPIIYVLLNKQ 0
0 FRNCMITTLCCGKNPLGDDDTSSAVSQSKTDVSSVSSSQVSPA* 0

>RHO2_danRer Danio rerio (zebrafish) Deut.Acti.Otoc genomic 15647516 full G? opn1mw1 ancestral representing 4x expansion
0 MNGTEGNNFYIPMSNRTGLVRSPYEYPQYYLAEPWQFKLLAVYMFFLICLGFPINGLTLLVTAQHKKLRQPLNFILVNLAVAGTIMVCFGFTVTFYSAINGYFVLGPTGCAIEGFMATLG 1
2 GEVALWSLVVLAIERYIVVCKPMGSFKFSSSHAMAGIAFTWVMAMACAAPPLFGWSR 2
1 YIPEGMQCSCGPDYYTLNPEYNNESYVLYMFICHGIVPVTIIFFTYGRLVCTVKA 0
0 AAAQQQESESTQKAEREVTRMVILMVLGFLVAWTPYATVAAWIFFNKGAAFSAQFMAVPAFFSKSSALFNPIIYVLLNKQ 0
0 FRNCMLTTLFCGKNPLGDDESSTVSTSKTEVSSVSPA* 0

>RHO2a_danRer Danio rerio (zebrafish) Deut.Acti.Otoc NM_131253 15647516 full G? opn1mw1
0 MNGTEGSNFYIPMSNRTGLVRSPYDYTQYYLAEPWKFKALAFYMFLLIIFGFPINVLTLVVTAQHKKLRQPLNYILVNLAFAGTIMVIFGFTVSFYCSLVGYMALGPLGCVMEGFFATLG 1
2 GQVALWSLVVLAIERYIVVCKPMGSFKFSANHAMAGIAFTWFMACSCAVPPLFGWSR 2
1 YLPEGMQTSCGPDYYTLNPEYNNESYVMYMFSCHFCIPVTTIFFTYGSLVCTVKA 0
0 AAAQQQESESTQKAEREVTRMVILMVLGFLFAWVPYASFAAWIFFNRGAAFSAQAMAVPAFFSKTSAVFNPIIYVLLNKQ 0
0 FRSCMLNTLFCGKSPLGDDESSSVSTSKTEVSSVSPA* 0

>RHO2b_danRer Danio rerio (zebrafish) Deut.Acti.Otoc NM_182891 15647516 full G? opn1mw2 highest expression
0 MNGTEGNNFYIPMSNRTGLVRSPYEYTQYYLADPWQFKALAFYMFFLICFGLPINVLTLLVTAQHKKLRQPLNYILVNLAFAGTIMAFFGFTVTFYCSINGYMALGPTGCAIEGFFATLG 1
2 GQVALWSLVVLAIERYIVVCKPMGSFKFSSNHAMAGIAFTWVMASSCAVPPLFGWSR 2
1 YIPEGMQTSCGPDYYTLNPEFNNESYVLYMFSCHFCVPVTTIFFTYGSLVCTVKA 0
0 AAAQQQESESTQKAEREVTRMVILMVLGFLVAWVPYASFAAWIFFNRGAAFSAQAMAIPAFFSKASALFNPIIYVLLNKQ 0
0 FRSCMLNTLFCGKSPLGDDESSSVSTSKTEVSSVSPA* 0

>RHO2c_danRer Danio rerio (zebrafish) Deut.Acti.Otoc NM_182892 15647516 full G? opn1mw3
0 MNGTEGNNFYIPMSNRTGLVRSPYEYPQYYLAEPWQFKLLAVYMFFLMCFGFPINGLTLVVTAQHKKLRQPLNFILVNLAVAGTIMVCFGFTVTFYTAINGYFVLGPTGCAIEGFMATLG 1
2 GQISLWSLVVLAIERYIVVCKPMGSFKFSSNHAFAGIGFTWIMALSCAAPPLVGWSR 2
1 YIPEGMQCSCGPDYYTLNPDYNNESYVLYMFCCHFIFPVTTIFFTYGRLVCTVKA 0
0 AAAQQQESESTQKAEREVTRMVILMVLGFLVAWTPYASVAAWIFFNRGAAFSAQFMAVPAFFSKSSSIFNPIIYVLLNKQ 0
0 FRNCMLTTLFCGKNPLGDDESSTVSTSKTEVSSVSPA* 0

>RHO2d_danRer Danio rerio (zebrafish) Deut.Acti.Otoc NM_131254 15647516 full G? opn1mw4
0 MNGTEGNNFYIPLSNRTGLARSPYEYPQYYLAEPWQFKLLAVYMFFLICLGFPINGLTLLVTAQHKKLRQPLNFILVNLAVAGTIMVCFGFTVTFYTAINGYFVLGPTGCAIEGFMATLG 1
2 GEVALWSLVVLAVERYIVVCKPMGSFKFSASHAFAGCAFTWVMAMACAAPPLVGWPR 2
1 YIPEGMQCSCGPDYYTLNPEYNNESYVLYMFICHFILPVTIIFFTYGRLVCTVKA 0
0 AAAQQQESESTQKAEREVTRMVILMVLGFLIAWTPYATVAAWIFFNKGAAFSAQFMAVPAFFSKTSALYNPVIYVLLNKQ 0
0 FRNCMLTTLFCGKNPLGDDESSTVSTSKTEVSSVSPA* 0

>RHO2_tetNig Tetraodon nigroviridis (pufferfish) Deut.Acti.Perc genomic full G? RH2
0 MVWDGGIEPNGTEGKNFYIPMSNRTGIVRSPFEYPQYYLVDPIMFKMLALYMFFLICTGTPINGLTLLVTAQNKKLRQPLNYILVNLAVAGLIMCAFGFTITITSAINGYFILGATACAVEGFMATLG 1
2 GEVALWSLVVLAIERYIVVCKPMGSFKFTGTHAAVGVLFTWIMAFACAGPPLFGWSR 2
1 YLPEGMQCSCGPDYYTLAPGYNNESYVIYMFVVHFFVPVFLIFFTYGSVVLTVka 0
0 AAAQQQESESTQKAQREVTRMCILMVLGFLVAWTPYATFSGWIFMNKGAAFHPLTAALCAFFAKSSALYNPVIYVLM 0
0 FRNCMLSTIGMGGAVDDETSVSASKTEVSSVS* 0

>RHO2_takRub Takifugu rubripes (fugu) Deut.Acti.Perc AF226989 10692583 full G?
0 MAWDGGIEPNGTEGKNFYIPMSNRTGIVRSPFEYPQYYLADPIMFKILALYMFFLICTGTPINGLTLLVTAQNKKLRQPLNYILVNLAVAGLIMCAFGFTITITSAVNGYFILGATACAVEGFMATLG 1
2 GEIALWSLVVLAVERYVVVCKPMGSFKFTGTHAAVGVAFTWIMAFACAAPPLFGWSR 2
1 YLPEGMQCSCGPDYYTLAPGYNNESYVIYMFSCHFFVPVITIFFTYGSLVLTVKA 0
0 AAAQQQESESTQKAQKEVTRMCILMVFGFLMAWTPYATFSAWIFMNKGAAFHPLTAAVCAFFAKSSALYNPVIYVLLNKQ 0
0 FRNCMLSTIGMGGAVDDETSVSASKTEVSSVS* 0

>RHO2_gasAcu Gasterosteus aculeatus (stickleback) Deut.Acti.Perc genomic full G? 2nd near-identical tandem copy
0 MAWEGGLEPNGTEGKNFYIPMSNRTGVVRSPFEYQQYYLADPIMFKILALYMFFLICTGTPINGLTLLVTAQNKKLRQPLNYILVNLAVAGLIMCAFGFTITITSAVNGYFILGATACAVEGFMATLG 1
2 GEVALWSLVVLAVERYIVVCKPMGSFKFSGTHAGAGVLFTWIMAMACAAPPLFGWSR 2
1 YLPEGMQCSCGPDYYTLAPGFNNESYVIYMFVVHFFTPVFIIFFTYGSLVLTVKA 0
0 AAAQQQESESTQKAEREVTRMCILMVFGFLVAWVPYASFAGWIFLNKGAPFSALTAAIPAFFAKSSALYNPVIYVLLNKQ 0
0 FRNCMLTTIGMGGMVEDETSVSASKTEVSSVS* 0

>RHO2_oryLat Oryzias latipes (medaka) Deut.Acti.Perc AB001603 9463691 full G?
0 MENGTEGKNFYIPMNNRTGLVRSPYEYPQYYLADPWQFKLLGIYMFFLILTGFPINALTLVVTAQNKKLRQPLNFILVNLAVAGLIMVCFGFTVCIYSCMVGYFSLGPLGCTIEGFMATLG 1
2 GQVSLWSLVVLAIERYIVVCKPMGSFKFTATHSAAGCAFTWIMASSCAVPPLVGWSR 2
1 YIPEGIQVSCGPDYYTLAPGFNNESFVMYMFSCHFCVPVFTIFFTYGSLVMTVKA 0
0 AAAQQQDSASTQKAEKEVTRMCFLMVLGFLLAWVPYASYAAWIFFNRGAAFSAMSMAIPSFFSKSSALFNPIIYILLNKQ 0
0 FRNCMLATIGMGGMVEDETSVSTSKTEVSTAA* 0

>RHO2_oreNil Oreochromis niloticus (tilapia) Deut.Acti.Perc AF247124 11470845 full G?
0 MAWEGGIEPNGTEGKNFYIPMSNRTGIVRNPFEYSQYYLADPIFFKLLAFYMFFLICTGTPINGLTLFVTAQNKKLRQPLNYILVNLAVAGLIMCCFGFTITITSAINGYFVLGTTFCAIEGFMATLG 1
2 GEVALWSLVVLAVERYIVVCKPMGSFKFTGAHAGAGVLFTWIMAMACAAPPLFGWSR 2
1 YIPEGMQCSCGPDYYTLAPGFNNESYVIYMFVVHFFVPVFIIFFTYGSLVMTVRA 0
0 AAAQQQDSASTQKAEKEVTRMCVLMVMGFLIAWTPYASFAGWIFLNKGAAFSALTAAIPAFFAKSSALYNPIIYVLMNKQ 0
0 FRNCMLSTIGMGGMVEDETSVSTSKTEVSSVS* 0

>RHO2_hipHip Hippoglossus hippoglossus (halibut) Deut.Acti.Perc AF156263 11925012 full G?
0 MVWDGGIEPNGTEGKNFYIPMSNRTGIVRSPFEYPQFYMVDSMMFKFLAFYMFFLVCTGTPINGLTLFVTAQNKKLRQPLNYILVNLAVAGLIMCCFGFTITITSAFNGYFILGATFCTIEGFMATLG 1
2 GEVALWSLVVLAVERYIVVCKPMGSFKFSGTHAGIGVLFTWVMAFACAGPPLFGWSR 2
1 YIPEGMQCSCGPDYYTLAPGFNNESYVIYMFVVHFFLPVFVIFFTYGSLVLTVKA 0
0 AAAQQQESESTQKAEKEVTRMCILMVFGFLFAWTPYATFAGWIFMNKGAAFTALTASIPAFFAKSSALYNPVIYVLLNKQ 0
0 FRNCMLSTIGMGGMVEDESSVSASKTEVSSVS* 0

>RHO2_mulSur Mullus surmuletus (mullet) Deut.Acti.Perc Y18680 full G?
0 MNGTEGKNFYIPMSNRTGIVRSPFEYPQYYMVDPMIYKLLAFYMFFLICTGTPINGLTLLVTFQNKKLQQPLNYILVNLAVVGLIMCAFGFTITITSALNGYFILGPTFCAIEGFMATLG 1
2 GEVALWSLVVLAVERYIVVCKPMGSFKFSGTHAGAGVAFTWIMAFACAGPPLFGWSR 2
1 YLPEGMQCSCGPDYYTLAPGFNNESYVIYMFVVHFFVPVFVIFFTYGSLVLTVKA 0
0 AAAQQQESESTQKAEREVTRMCILMVIGFLVAWVPYATFAGWIFLNKGAAFTALTAALPAFFAKSSALYNPVIYVMMNKQ 0
0 FRNCILSAIGMGGMVEDETSVSTSKTEVSTAS* 0

>RHO2_pomMin Pomatoschistus minutus (sand_goby) Deut.Acti.Perc Y18679 full G?
0 MNGTEGKNFYIPMSNRTGIVRSPYEYPQYYMVDPWIYKLLAFYMFFLICTGTPINALTLLVTFQNKKLRQPLNFILVNLAVAGLIMCAFGFTITITSALNGYFILGATFCAIEGFMATLG 1
2 GEVALWSLVVLAVERYIVVCKPMGSFKFSGAHAGAGVALTWIMAMACAAPPLFGWSR 2
1 YLPEGMQCSCGPDYYTLAPGFNNESYVMYMFVVHFFIPVFLIFFTYGSLVLTVKA 0
0 AAAQQQDSASTQKAEKEVTRMCFLMVMGFLVAWVPYASFAGWIFLNKGAAFTAMTAAIPAFFAKSSALYNPVIYVLMNKQ 0
0 FRNCMLSAVGMGGMVDDETSVSASKTEVSSVS* 0

>RHO2_calMil Callorhinchus milii (elephantfish) Deut.Chon.Holo EF565168 19196633 full G?
0 MNGTKGSNFYIPMSNRTGVVRNPFEYPQYYLADRWLFSSISAYMFLLICAGLPINGLTLLVTVKHKKLRQPLNFILLNLAVADLFMVFGGFFITVYTSLHGYFVFGVTGCNFEGFFATLG 1
2 GEIGLWSLVVLAIERYVVVCKPMSNFRFGTSHALMGMGFTWFMALTAAVPPLVGWSR 2
1 FIPEGFQCSCTPDFYTTNPLYNNDSYLMYLFSVHFAFPVTLIFFSYGRLICKVKE 0
0 AAAQQQESATTQKAEKEVTRMVILMVIGFLTAWLPYASLSIWIFTHQGAWISPLLMTIPSFFSKSSVLYNPIIYILMNKQ 0
0 FRSSMITTVCCGKNPFGDDDSSSVTSQSKTEVSSVSTSQVSPA* 0

>RHO2_geoAus Geotria australis (lamprey) Deut.Agna.Hype AY366494 17463225 full Gt RhB
0 MNGTEGANFYIPFHNRTGVVRSPYEYPQYYLADPWMYSAISAYVFTLILIGFPVNFMTLFVTFKLKKLRQPLNFILVNLCVADLLMIMFGFTTTFYTAMNGYFVFGPTGCNIEGFFATLG 1
2 GEVSLWSLVMLAIERYIVVCKPMGNFRFATTHAALGVVFTWVMASACAVPPLVGWSR 2
1 YIPEGMQCSCGPDYYTLNPKYYNESYVIYLFLVHFLLPVTIIFFTYGRLICTVKE 0
0 AAAQQQESASTQKAEREVTRMVIIMVVGFLVCWVPYASFAFYLFMNKGILFSATAMTVPAFFSKSSVLYNPIIYVLLNKQ 0
0 FRTCMVTTLFCGKNPFGEDDSSMVSTSKTEVSSVSSSQVSPS* 0

>SWS2_ornAna Ornithorhynchus anatinus (platypus) Deut.Prot.Mono ABN43074 17339011 full Gt syn(-IRAK1 -MECP2 - +TKTL1) blue tandem with MWS1
0 MHKTHRNLQNELPEDFFIPLPLDTDNITSLSPFLVPQTHLGGSGIFMSLAAFMFLLITLGFPINLLTVICTIKYKKLRSHLNYILVNLAVSNMLVVCVGSATAFYSFAHMYFVLGPTACKIEGFAATLG 1
2 GMVSLWSLAVIAFERFLVICKPLGNLSFRGTHAIFGCAATWVFGLAASLPPLFGWSR 2
1 YIPEGLQCSCGPDWYTTNNKWNNESYVIFLFSFCFGVPLSIIIFSYGRLLLTLRA 0
0 VAKQQEQSATTQKAEREVTKMVIVMVLGFLVCWLPYASFSLWVVTNRGQVFDLRMASIPSVFSKASTIYNPIIYVFMNKQ 0
0 FRSCMLKLVFCGKSPFGDEDEISGSSQATQVSSVSSSQVSPA* 0

>SWS2_galGal Gallus gallus (chicken) Deut.Saur.Arch NP_990848 7975342 full Gt
0 MHPPRPTTDLPEDFYIPMALDAPNITALSPFLVPQTHLGSPGLFRAMAAFMFLLIALGVPINTLTIFCTARFRKLRSHLNYILVNLALANLLVILVGSTTACYSFSQMYFALGPTACKIEGFAATLG 1
2 GMVSLWSLAVVAFERFLVICKPLGNFTFRGSHAVLGCVATWVLGFVASAPPLFGWSR 2
1 YIPEGLQCSCGPDWYTTDNKWHNESYVLFLFTFCFGVPLAIIVFSYGRLLITLRA 0
0 VARQQEQSATTQKADREVTKMVVVMVLGFLVCWAPYTAFALWVVTHRGRSFEVGLASIPSVFSKSSTVYNPVIYVLMNKQ 0
0 FRSCMLKLLFCGRSPFGDDEDVSGSSQATQVSSVSSSHVAPA* 0

>SWS2_taeGut Taeniopygia guttata (finch) Deut.Saur.Arch genomic full Gt
0 MPKPREMRDELPEDFYIPMSLETPNLTALSPFLVPQTHLGSPGIFKAMAAFMFLLVLLGVPINALTVLCTAKYKKLRSHLNYILVNLAVANLLVVCVGSTTAFYSFSQMYFALGPLACKIEGFTATLG 1
2 GMVSLWSLAVVAFERFLVICKPLGNFTFRGSHAVLGCAITWIFGLIASLPPLFGWSR 2
1 YIPEGLQCSCGPDWYTTDNKWNNESYVIFLFCFCFGFPLTVIVFSYGRLLLTLRA 0
0 VAKQQEQSASTQKAEREVTKMVVVMVLGFLVCWLPYCSFALWVVTHRGHPFDLGLASIPSVFSKASTVYNPIIYVFMNKQ 0
0 FRSCMLKLVFCGRSPFGDEDDVSGSSQATQVSSVSSSQVSPA* 0

>SWS2_anoCar Anolis carolinensis (lizard) Deut.Saur.Lepi genomic full G?
0 MQKSRPDSRDNLPEDFFIPVPLDVANITTLSPFLVPQTHLGNPSLFMGMAAFMFILIVLGVPINVLTIFCTFKYKKLRSHLNYILVNLSVSNLLVVCVGSTTAFYSFSNMYFSLGPTACKIEGFSATLG 1
2 GMVSLWSLAVVAFERYLVICKPLGNFTFRGTHAIIGCAVTWMFGLAASLPPLFGWSR 2
1 YIPEGLQCSCGPDWYTTENKWNNESYVIFLFCFCFGVPLSVIIFSYGRLLLTLRA 0
0 VAKQQEQSATTQKAEREVTKMVVVMVMGFLVCWLPYASFALWVVTHRGEPFDVRLASIPSVFSKASTVYNPVIYVLMNKQ 0
0 FRSCMLKLIFCGKSPFGDEDDVSGSSQATQVSSVSSSQVSPA* 0

>SWS2_utaSta Uta stansburiana (lizard) Deut.Saur.Lepi DQ100326 16543463 full Gt
0 MHNSRPHSRDDLPEDFFIPMPLDVANITTLSPFLVPQTHLGSPALFMGMAAFMFLLIILGVPINVLTIFCTFKYKKLRSHLNYILVNLAVSNLLVVCIGSTTAFYSFAQMYFSLGPTACKIEGFAATLG 1
2 GMVSLWSLAVVAFERFLVICKPLGNFSFRGTHAIIGCIITWVFGLVASLPPLFGWSR 2
1 YIPEGLQCSCGPDWYTTNNKWNNESYVLFLFSFCFGVPLSVIIFSYGRLLLTLRA 0
0 VAKQQEQSATTQKAEREVTKMVVVMVMGFLVCWLPYASFALWVVTHRGEPFDVRLATIPSVFSKASSVYNPVIYVFMNKQ 0
0 FRSCMLKLVFCGKSPFGDEDDVSGSSQTTQVSSVSSSQVSPA* 0

>SWS2_xenTro Xenopus tropicalis (frog) Deut.Amph.Anur genomic full Gt syn(-IRAK1 -MECP2 -)
0 MSKGRPDLRMEMPDEFYVPIPLETTNISSLSPFLVPQTHLGTPGIFMSISAFMLFTIIFGFPLNLLTIICTVKYKKLRSHLNYILVNLAVANLIVICFGSTTAFYSFSQMYFSLGTLACKIEGFTATLG 1
2 GIIGLWSLAVVAFERFLVICKPMGNFTFRESHAVLGCILTWVIGLVAAIPPLLGWSR 2
1 YIPEGLQCSCGPDWYTVNNKWNNESYVLFLFCFCFGFPLAIIVFSYGRLLLALHA 0
0 VAKQQEQSATTQKAEREVTRMVIVMVVGFLVCWLPYASFALWAVTHRGELFDLRMSSVPSVFSKASTVYNPFIYIFMNRQ 0
0 FRSCMMKMIFCGKNPLGDDEETSVSGSTQVSSVSSSQIAPS* 0

>SWS2_neoFor Neoceratodus forsteri (lungfish) Deut.Sarc.Dipn EF526299 17961206 full Gt
0 MHRTKPDPQEDLPDDFYIPVSLNTNNITMLSPFLVPQTHLGSPSVFMVLSVFMFFLLITGIPINVLTIICTFKYKKLRSHLNYILVNLAVANLIVVGFGSTTAFYSFSQMYFAWGPLACKIEGFAATLG 1
2 GMVSLWSLAVVAFERFLVICKPLGNFTFRSTHAIIGCVATWVFGLISSAPPLFGWSR 2
1 YIPEGLQCSCGPDWYTTNNKWNNESYVIFLFCFCFGFPLSVIIFSYGRLLMTLRA 0
0 VAKQQEQSASTQKAEREVTKMVVVMVLGFLVCWLPYTVFSLWVVTHRGESFELALGSIPAVFSKSSTVYNPLIYVFMNKQ 0
0 FRSCMMKLIFCGKSPFGDEDDASSASQSTQVSSVSSSQVAPA* 0

>SWS2_tetNig Tetraodon nigroviridis (pufferfish) Deut.Acti.Perc genomic full G?
0 MRGNRQHEFQEDFFIPIPLEVDNITALSPFLVPQDHLGSPALFYGMAAFMFCLFVSGTGINALTIACTVKYKKLRSHLNYILVNLAVSNLLVTCVGSFTCFCCFTVRYMFVGPLGCKIEGFAATLG 1
2 GMVSLWSLAVVAFERWLVVCKPLGNFIFKPDHAIACCAATWLFALVVSGPPLFGWSR 2
1 YIPEGFQCSCGPDWYTTGNKYNNESYVMFIFGFGFAVPFFVIVFCYSQLLFVLKS 0
0 AQAESASTQKAEKEVTRMVVVMIFGFLVCWLPYASFALWAVNNRGTPFDLRLATIPACFSKSSAVYNPVIYVVLNKQ 0
0 FRSCMKKMLGMSGGDDEDSSASQSVTEVSKVSPS* 0

>SWS2_takRub Takifugu rubripes (fugu) Deut.Acti.Perc genomic full Gt
0 MRGVRQHEFQEDFYIPIPLDVDNITALSPFLVPQDHLGSPAVFYGMSAFMFFLFVAGTGINVLTIACTIQYKKLRSHLNYILVNLAFSNLLVTTVGSFTCFCCFFVRYMIVGPLGCKIEGFAATLG 1
2 GMVSLWSLAVVAFERWLVVCKPLGNFIFKPDHAIVCCIFTWFFALIISAPPLFGWSR 2
1 YIPEGFQCSCGPDWYTTGNKYNNESYVWFIFGFGFAVPLFVIVFCYSQLLVMLKS 0
0 AKAQAESASTQKAEREVTRMVVVMILGFLVCWLPYASFALWVVNNRGTPFDLRLATIPACFSKASTVYNPIIYVVLNKQ 0
0 FRSCMKKMLGMSGGDDEESSSQSVTEVSKVSPS* 0

>SWS2_gasAcu Gasterosteus aculeatus (stickleback) Deut.Acti.Perc genomic full Gt
0 MKHGRVPEIPEDFYIPISLDTDNITSLSPFLVPQDHLASKATFYSLAFYMFFILIVGTFINALTVACTVQNKKLRSHLNYILVNLAVSNLLVSGVGAFTAFLSFAARYFVLGTLACKVEGFLATLG 1
2 GMVSLWSLAVIAFERWLVICKPLGNFIFKPDHALVCCAFTWVFALAASAPPLVGWSR 2
1 YIPEGLQCSCGPDWYTTNNKYNNESYVLFLFGFCFAVPFCTICFCYSQLLFTMKMA 0
0 AKAQAESASTQKAEREVTRMVVLMVMGFLVCWMPYASFALWVVNNRGQTFDLRFASIPSVFSKSSAVYNPVIYVLLNKQ 0
0 FRSCMMKMLGMGGGDDEESSTSSVTEVSKVGPA* 0

>SWS2_oryLat Oryzias latipes (medaka) Deut.Acti.Perc AB223056 16460888 full Gt
0 MRFISGGELPDDFWIPIPLDTNNLSLLSPFLVPQDHLGSSGTFYAMAAFMFFLFVFGTSINSLTIACTFQNKKLRSHLNYILVNLSVANLLVSGVGSSTAFCSFACRYFVFGSLACKIEGFAATLG 1
2 GMVGLWSLAVIAFERWLVICKPLGNFTFKPEHALACCLVTWVCALAAAAPPLAGWSR 2
1 YIPEGLQCSCGPDWYTTNNKYNNESYVMFLFCFCFAVPFATIVFCYSQLLVTLKMA 0
0 AKAQAESASTQKAEREVTRMVVVMVLGFLVCWMPYASFALWVVNNRGHSFDLRLATIPSCLSKASTVYNPVIYVLLNKQ 0
0 FRSCMLTMLGMGGGEEEDSTSVTEVSKVGPA* 0

>SWS2_geoAus Geotria australis (lamprey) Deut.Agna.Hype AY366492 17463225 full Gt
0 MYQGKSTQVDDLPEDFYIPIALNVKNMSELSPFLVPQVHLGDSFIFYGMSAFMLFLVLAGFPLNFLTVFVTIKYKKLRSHLNYILVNLAIANLIVVCCGSTLAFYSFMHKYFILGPLFCKMEGFTATLG 1
2 GMLSLWSLAVLAFERCLVICKPFGNIAFRGTHALIRCGFAWAAAIAASTPPLFGWSR 2
1 YIPEGLQCSCGPDWYTTNNKYNNESYVMFLFIFCFGTPFTIIIVSYSKLILTLRA 0
0 AAAQQQESASTQKAEKEVSRMVVIMVGGFLVCWLPYASLALWIVFNRGSPFDLRLATIPSVFSKASTVYNPVIYIFLNKQ 0
0 FRSCMMKTIFCGKNPLGDDEDATSTTTQVSSVSTSQVAPA* 0

>SWS1_homSap Homo sapiens (human) Deut.Euth.Euar NM_001708 1385866 full Gt OPN1SW syn(-FAM137A +SWS1 -CALU -NAG6 -FLNC)
0 MRKMSEEEFYLFKNISSVGPWDGPQYHIAPVWAFYLQAAFMGTVFLIGFPLNAMVLVATLRYKKLRQPLNYILVNVSFGGFLLCIFSVFPVFVASCNGYFVFGRHVCALEGFLGTVA 1
2 GLVTGWSLAFLAFERYIVICKPFGNFRFSSKHALTVVLATWTIGIGVSIPPFFGWSR 2
1 FIPEGLQCSCGPDWYTVGTKYRSESYTWFLFIFCFIVPLSLICFSYTQLLRALKA 0
0 VAAQQQESATTQKAEREVSRMVVVMVGSFCVCYVPYAAFAMYMVNNRNHGLDLRLVTIPSFFSKSACIYNPIIYCFMNKQ 0
0 FQACIMKMVCGKAMTDESDTCSSQKTEVSTVSSTQVGPN* 0

>SWS1_monDom Monodelphis domesticus (opossum) Deut.Meta.Dide genomic full Gt OPN1SW syn(-FAM137A +SWS1 -CALU -NAG6 -FLNC)
0 MSGDEEFYLFKNISSVGPWDGPQYHIAPAWAFHFQTVFMGFVFCAGTPLNAVVLVATLRYKKLRQPLNYILVNVSLCGFIFCIFAVFTVFISSSQGYFIFGRHVCAMEAFLGSVA 1
2 GLVTGWSLAFLAFERFIVICKPFGNFRFNSKHAMMVVLATWVIGIGVSIPPFFGWSR 2
1 FIPEGLQCSCGPDWYTVGTKYRSEYYTWFLFIFCFIMPLFLICFSYSQLLRALRA 0
0 VAAQQQESATTQKAEREVSRMVVMMVGSFCLCYVPYAALAMYMVNNQNHGLDLRLVTIPAFFSKSACVYNPIIYCFMNKQ 0
0 FHACIMEMVCRKPMTDDSDVSSSQKTEVSAVSSSQVGPT* 0

>SWS1_smiCra Sminthopsis crassicaudata (dunnart) Deut.Meta.Dasy AY442173 full G? OPN1SW
0 MSGDEEFYLFKNISLVGPWDGPQYHLAPAWAFHFQTAFMGFVFFAGTSLNGVVLIATLRYKKLRQPLNYILVNISLAGFIFCVFSVFTVFVSSSQGYFVFGRHVCAMEGFLGSVA 1
2 GLVTGWSLAFLAFERFIVICKPFGNFRFNSKHAMMVVLATWIIGIGVSIPPFFGWSR 2
1 YIPEGLQCSCGPDWYTVGTKYRSEYYTWFLFIFCFIVPLSLICFSYSQLLGALRA 0
0 VAAQQQESATTQKAEREVSRMVVVMVGSFCLCYVPYAAMAMYMVNNRNHGLDLRLVTIPAFFSKSACVYNPIIYCFMNKQ 0
0 FHACIMEMICKKPMTDDSETTSSQKTEVSTVSSSQVGPS* 0

>SWS1_tarRos Tarsipes rostratus (honey_possum) Deut.Meta.Dipr AY772472 18426754 full G? OPN1SW
0 MSGDEEFYLFKDISSVGPWDGPQYHIAPAWAFHFQTTFMGFVFFAGTPLNAVVLIATLRYKKLRQPLNYILVNISLAGFIFCVISVFTVFISSSQGYFIFGRHVCAMEAFLGSVA 1
2 GLVTGWSLAFLAFERFIVICKPFGNFRFSSKHAMMVVLATWVIGIGVSIPPFFGWSR 2
1 YIPEGLQCSCGPDWYTVGTKYHSEYYTGFLFIFCFIVPLSLICFSYSQLLGALRA 0
0 VAAQQQESATTQKAEREVSRMVVVMVGSFCLCYVPYAALAMYMVNNRNHGLDLRLVTIPAFFSKSACVYNPIVYWFMNKQ 0
0 FHACIMEMVCRKPMTDDSEISSSQKTEVSTVSSSQVGPS* 0

>SWS1_galGal Gallus gallus (chicken) Deut.Saur.Arch genomic full Gt OPN1SW violet
0 MSSDDDFYLFTNGSVPGPWDGPQYHIAPPWAFYLQTAFMGIVFAVGTPLNAVVLWVTVRYKRLRQPLNYILVNISASGFVSCVLSVFVVFVASARGYFVFGKRVCELEAFVGTHG 1
2 GLVTGWSLAFLAFERYIVICKPFGNFRFSSRHALLVVVATWLIGVGVGLPPFFGWSR 2
1 YMPEGLQCSCGPDWYTVGTKYRSEYYTWFLFIFCFIVPLSLIIFSYSQLLSALRA 0
0 VAAQQQESATTQKAEREVSRMVVVMVGSFCLCYVPYAALAMYMVNNRDHGLDLRLVTIPAFFSKSACVYNPIIYCFMNKQ 0
0 FRACIMETVCGKPLTDDSDASTSAQRTEVSSVSSSQVGPT* 0

>SWS1_taeGut Taeniopygia guttata (finch) Deut.Saur.Arch genomic full Gt OPN1SW
0 MDEEEFYLFKNQSSVGPWDGPQYHIAPMWAFYLQTIFMGLVFVAGTPLNAIVLIVTIKYKKLRQPLNYILVNISVSGLMCCVFCIFTVFIASSQGYFVFGKHMCAFEGFAGATG 1
2 GLVTGWSLAFLAFERYIVICKPFGNFRFNSRHALLVVAATWIIGVGVAIPPFFGWSR 2
1 YIPEGLQCSCGPDWYTVGTKYKSEYYTWFLFIFCFIVPLSLIIFSYSQLLSALRA 0
0 VAAQQQESATTQKAEREVSRMVVVMVGSFCMCYVPYAALAMYMVNNREHGIDLRLVTIPAFFSKSSCVYNPIIYCFMNKQ 0
0 FRACIMETVCGRPMTDDSEVSSSAQRTEVSSVSSSQVGPS* 0

>SWS1_anoCar Anolis carolinensis (lizard) Deut.Saur.Lepi genomic full Gt OPN1SW syn(+SWS1 -CALU)
0 MSGQEDFYLFENISSVGPWDGPQYHIAPMWAFYFQTAFMGFVFFAGTPLNAIILIVTVKYKKLRQPLNYILVNISFAGFLFCTFSVFTVFMASSQGYFFFGRHVCAMEAFLGSVA 1
2 GLVTGWSLAFLAFERYIVICKPFGNFRFNSRHALLVVAATWIIGVGVAIPPFFGWSR 2
1 YIPEGLQCSCGPDWYTVGTKYKSEYYTWFLFIFCFIVPLTLIIFSYSQLLGALRA 0
0 VAAQQQESATTQKAEREVSRMVVVMVGSFCLCYVPYASLAMYMVNNRDHGLDLRLVTIPAFFSKSSCVYNPIIYCFMNKQ 0
0 FRACILETVCGKPMSDESDVSSSAQKTEVSSVSSSQVSPS* 0

>SWS1_utaSta Uta stansburiana (lizard) Deut.Saur.Lepi DQ100325 16543463 full Gt OPN1SW
0 MSGEEDFYLFENISSVGPWDGPQYHIAPMWAFYFQTAFMGFVFFAGTPLNAIILIVTVKYKKLRQPLNYILVNISFAGFLFCVFSVFTVFLASSQGYFFFGRHICALEAFLGSVA 1
2 GLVTGWSLAFLAFERYIVICKPFGNFRFNSKHALLVVAATWFIGIGVSIPPFFGWSR 2
1 FIPEGLQCSCGPDWYTVGTKYKSEYYTWFLFIFCFIVPLTLIIFSYSQLLGALRA 0
0 VAAQQQESATTQKAEREVSRMVVVMVGSFCLCYVPYAALAMYMVNNRDHGIDLRLVTIPAFFSKSACVYNPIIYCFMNKQ 0
0 FRACIMETVCGKPMTDESDVSSSAQKTEVSSVSSSQVSPS* 0

>SWS1_xenLae Xenopus laevis (frog) Deut.Amph.Anur genomic full Gt OPN1SW syn(+SWS1 -CALU)
0 MLEEEDFYLFKNVSNVSPFDGPQYHIAPKWAFTLQAIFMGMVFLIGTPLNFIVLLVTIKYKKLRQPLNYILVNITVGGFLMCIFSIFPVFVSSSQGYFFFGRIACSIDAFVGTLT 1
2 GLVTGWSLAFLAFERYIVICKPMGNFNFSSSHALAVVICTWIIGIVVSVPPFLGWSR 2
1 YMPEGLQCSCGPDWYTVGTKYRSEYYTWFIFIFCFVIPLSLICFSYGRLLGALRA 0
0 VAAQQQESASTQKAEREVSRMVIFMVGSFCLCYVPYAAMAMYMVTNRNHGLDLRLVTIPAFFSKSSCVYNPIIYSFMNKQ 0
0 FRGCIMETVCGRPMSDDSSVSSTSQRTEVSTVSSSQVSPA* 0

>SWS1_neoFor Neoceratodus forsteri (lungfish) Deut.Sarc.Dipn EF526299 17961206 full Gt OPN1SW
0 MSGEEEFYLFKNISSVGPWDGPQYHIAPKWAFFLQAAFMGFVLFVGTPLNAIVLFVTIKYKKLQQPLNYILVNISLAGFIFCFFGVFAVFIASCQGYFIFGKTVCALEGFTGSVA 1
2 GLVTGWSLAILAFERYLVICKPIGNFRFGSKHSMIAVVAAWVIGVGVSIPPFFGWSR 2
1 YIPEGLQCSCGPDWYTVGTKYKSEYYTWFLFIFCFIIPLFIICFSYSQLLGALRA 0
0 VAAQQQESATTQKAEREVSRMIIVMVGSFCVCYVPYAALAMYMVNNRDHGIDLRLVTIPAFFSKSSFVYNPIIYCFMNKQ 0
0 FRACIMQTVFGKPMTDDSDISSSGKTEVSSVSSSQVNPS*

>SWS1_danRer Danio rerio (zebrafish) Deut.Acti.Otoc genomic full Gt OPN1SW syn(-PNPLAS +IRG5 -TNPO3 +SWS1 -CALU -DYRK2)
0 MDAWAVQFGNASKVSPFEGEQYHIAPKWAFYLQAAFMGFVFIVGTPMNGIVLFVTMKYKKLRQPLNYILVNISLAGFIFDTFSVSQVSVCAARGYYSLGYTLCSMEAAMGSIA 1
2 GLVTGWSLAVLAFERYVVICKPFGSFKFGQGQAVGAVVFTWIIGTACATPPFFGWSR 2
1 YIPEGLGTACGPDWYTKSEEYNSESYTYFLLITCFMMPMTIIIFSYSQLLGALRA 0
0 VAAQQAESESTQKAEREVSRMVVVMVGSFVLCYAPYAVTAMYFANSDEPNKDYRLVAIPAFFSKSSSVYNPLIYAFMNKQ 0
0 FNACIMETVFGKKIDESSEVSSKTETSSVSA* 0

>SWS1_gasAcu Gasterosteus aculeatus (stickleback) Deut.Acti.Perc DW624108 full G? OPN1SW syn(ARF4 +IRG5 -TNPO3 +SWS1) BT028514 brain transcript
0 MGKHFHLYENISKVDPFEGPQYYLAPMWAFYLQTAFMGFVFFAGTPLNFTVLLVTAKYKKLRVPLNYILVNITLAGFIFVTFSVSQVFVASARGYYFLGYTLCALEAAMGSVA 1
2 GLVTAWSLAVLSFERYLIICKPFGAFKFTSNHALGAVAFTWFMGICCSSPPFFGWSR 2
1 YIPEGLGCSCGPDWYTHNVEFNCTSYLYFLIVTCFIMPLSIIIFSYSQLLGALRA 0
0 VAAQQAESESTQKAEKEVSKMIIVMVGSFVACYAPYAITGLWFAFSPDENKDYRLVTVPAYFSKSSCVYNPLIYAFMNKQ 0
0 FNACIMETVFGKPMDESSEVSSKTEVSSVSTAS* 0

>SWS1_oryLat Oryzias latipes (medaka) Deut.Acti.Perc genomic full Gt OPN1SW syn(-TNPO3 +SWS1 +SOCS2 -CRADD +ARHGAP8)
0 MGKYFYLYENISKVGPYDGPQYYLAPTWAFYLQAAFMGFVFFVGTPLNFVVLLATAKYKKLRVPLNYILVNITFAGFIFVTFSVSQVFLASVRGYYFFGQTLCALEAAVGAVA 1
2 GLVTSWSLAVLSFERYLVICKPFGAFKFGSNHALAAVIFTWFMGVGCACPPFFGWSR 2
1 YIPEGLGCSCGPDWYTNCEEFSCASYSKFLLVTCFICPITIIIFSYSQLLGALRA 0
0 VAAQQAESASTQKAEKEVSRMIIVMVASFVTCYGPYALTAQYYAYSQDENKDYRLVTIPAFFSKSSCVYNPLIYAFMNKQ 0
0 FNGCIMEMVFGKKMEEASEVSSKTEVSTDS*0

>SWS1_petMar Petromyzon marinus (lamprey) Deut.Agna.Hype genomic pseu G? OPN1SW exonic pseudogene frameshifts stops no synteny homSap
0 MSGDEEFYLFKNISKVGPLDGPHFHIATKWAFDFQAAFMGFVFLCGtPLNAIVLIVTVKCKKLRQPLTYMLVNISAAGLVFCLFSISTVFLFSTQGYFVFGPTVCALESLFGSMA 1
2 GLVTGWSLAFLAAERYIVICKPFGNFRFGSIHSLFAFCLTWVLGLGVALPPFFGWSR 2
1 YIPeGLQCSCSPDWNTVGTKYESEYCTYFLFVFCFFVQLSIIIFSYGKLLNTLra 0
0 VAVQqQESSLSSTQKAEREMSRMVIVMVGSFCTCYVAALALYVVTNRDHNIDLRFVTVPAFFSKASCVYNPLIYSFMNKQ 0
0 FRARIMETVCGKFITDESETSSSRTAVSSVSTSQVSPG* 0

>SWS1_geoAus Geotria australis (lamprey) Deut.Agna.Hype AY366495 17463225 full Gt OPN1SW
0 MSGDEEFYLFKNISKVGPWDGPQFHIAPKWAFYLQAAFMGFVFICGTPLNAIVLVVTIKYKKLRQPLNYILVNISAAGLVFCLFSISTVFVASMQGYFFLGPTICALEAFFGSLA 1
2 GLVTGWSLAFLAAERYIVICKPFGNFRFGSKHALVAVGLTWMLGLSVALPPFFGWSR 2
1 YIPEGLQCSCGPDWYTVGTKYKSEYYTYFLFVFCFVVPLSIIIFSYGSLLGTLRA 0
0 VAAQQQESASTQKAEREVSRMVIMMVASFCTCYVPYAALAVYMVTNRDHNIDLRFVTVPAFFSKASCVYNPLIYSFMNKQ 0
0 FRACILETVCGKPITDESETSSSRTEVSSVSTTQMIPG* 0

>LWS_homSap Homo sapiens (human) Deut.Euth.Euar NP_000504 12853434 full Gt OPN1LW long wavelength syn(-IRAK1 -MECP2 -TEX28) OPN1MW deutan
0 MAQQWSLQRLAGRHPQDSYEDSTQSSIFTYTNSNSTR 1
2 GPFEGPNYHIAPRWVYHLTSVWMIFVVIASVFTNGLVLAATMKFKKLRHPLNWILVNLAVADLAETVIASTISVVNQVYGYFVLGHPMCVLEGYTVSLC 1
2 GITGLWSLAIISWERWMVVCKPFGNVRFDAKLAIVGIAFSWIWAAVWTAPPIFGWSR 2
1 YWPHGLKTSCGPDVFSGSSYPGVQSYMIVLMVTCCITPLSIIVLCYLQVWLAIRA 0
0 VAKQQKESESTQKAEKEVTRMVVVMVLAFCFCWGPYAFFACFAAANPGYPFHPLMAALPAFFAKSATIYNPVIYVFMNRQ 0
0 FRNCILQLFGKKVDDGSELSSASKTEVSSVSSVSPA* 0

>LWS_monDom Monodelphis domesticus (opossum) Deut.Meta.Dide genomic full G? OPN1LW long wavelength exon 1:4 residue insert
0 MTQAWDPAGFLARRRDVNEDDNDETTRSSLFVYTNSNNTR 1
2 GPFEGPNYHIAPRWVYNLTSLWMVFVVIASIFTNGLVLVATMKFKKLRHPLNWILVNLAVADLGETVIASTISVINQIYGYFILGHPLCVLEGYTVSLC 1
2 GITGLWSLAIISWERWVVVCKPFGNVKFDAKLAMVGIIFSWVWAAVWTAPPLFGWSR 2
1 YWPHGLKTSCGPDVFSGSSDPGVQSYMIVLMATCCIFPLSIILLCYVQVWLAIRA 0
0 VAKQQKESESTQKAEKEVSRMVVVMILAYCFCWGPYTLFACFAAANPGYSFHPLTASLPAYFAKSATIYNPIIYVFMNRQ 0
0 FRTCILQLFGKKVDDGSEVSSTSKTEGSSVSSVAPA* 0

>LWS_macEug Macropus eugenii (wallaby) Deut.Meta.Dipr genomic full G? OPN1LW long wavelength
0 MTQAWDPAGFLAWRRDENEETTRASLFVYTNSNNTK 1
2 GPFEGPNYHIAPRWVFNLTSLWMIFVVIASIFTNGLVLVATMKFKKLRHPLNWILVNLAVADLGETLIASTISVINQIYGYFILGHPMCVLEGYTVSLC 1
2 GITGLWSLAIISWERWVVVCKPFGNVKFDAKLAMVGIVFSWVWAAVWTAPPLFGWSR 2
1 YWPHGLKTSCGPDVFSGNSDPGVQSYMIVLMSTCCILPLSVIFLCYIQVWLAIRS 2
0 VAKQQKESESTQKAEKEVSRMVVVMILAFCFCWGPYAIFACFAAANPGYAFHPLTASLPAYFAKSATIYNPIIYVFMNRQ 0
0 FRTCILQLFGKKVDDGSEVSSTSRTEVSSVSSVAPA* 0

>LWS_smiCra Sminthopsis crassicaudata (dunnart) Deut.Meta.Dasy EU232013 18426754 full G? OPN1LW long wavelength
0 MTQAWDPAGFLAWRRDENEETTRASLFVYTNSNNTK 1
2 GPFEGPNYHIAPRWVYNLTSLWMIFVVIASVFTNGLVLVATMKFKKLRHPLNWILVNLAVADLGETIIASTISVINQIYGYFILGHPMCVLEGYTVSLC 1
2 GITGLWSLAIISWERWVVVCKPFGNVKFDAKLAMVGIVFSWVWAAVWTAPPIFGWSR 2
1 YWPHGLKTSCGPDVFSGSSDPGVQSYMIVLMSTCCILPLSIIILCYIQVWLAIRA 0
0 VAKQQKESESTQKAEKEVSRMVMVMILAFCFCWGPYALFACFAAANPGYAFHPLTASLPAYFAKSATIYNPIIYVFMNRQ 0
0 FRTCILQLFGKKVDDGSEVSSTSRTEVSSVSSVAPA* 0

>LWS_ornAna Ornithorhynchus anatinus (platypus) Deut.Prot.Mono ABN43074 17339011 full Gt OPN1LW long wavelength syn(-IRAK1 -MECP2 - -) LWS green
0 MTPAWNSGVYAARRRFEDEEDTTRTSVFVYTNSNNTR 1
2 DPFEGPNYHIAPRWAYNVTSLWMIFVVIASVFTNGLVLVATMKFKKLRHPLNWILVNLAVADLGETLIASTISVINQIFGYFILGHPMCVLEGYTVSLC 1
2 GITGLWSLSIISWERWIVVCKPFGNVKFDAKLAMVGIVFSWVWAAVWTAPPIFGWSR 2
1 YWPHGLKTSCGPDVFSGSSDPGVQSYMIVLMSTCCILPLSIIVLCYLQVWLAIRA 0
0 VAKQQKESESTQKAEKEVSRMVVVMILAYCFCWGPYTIFACFAAANPGYAFHPLAAALPAYFAKSATIYNPIIYVFMNRQ 0
0 FRNCIMQLFGKKVDDGSELSSTSRTEVSSVSSVSPA* 0

>LWS_galGal Gallus gallus (chicken) Deut.Saur.Arch NM_205438 12716987 full Gt OPN1LW iodopsin missing in assembly
0 MAAWEAAFAARRRHEEEDTTRDSVFTYTNSNNTR 1
2 GPFEGPNYHIAPRWVYNLTSLWMIFVVAASVFTNGLVLVATWKFKKLRHPLNWILVNLAVADLGETVIASTISVINQISGYFILGHPMCVVEGYTVSAC 1
2 GITALWSLAIISWERWFVVCKPFGNIKFDGKLAVAGILFSWLWSCAWTAPPIFGWSR 2
1 YWPHGLKTSCGPDVFSGSSDPGVQSYMVVLMVTCCFFPLAIIILCYLQVSLAIRA 0
0 VAAQQKESESTQKAEKEVSRMVVVMIVAYCFCWGPYTFFACFAAANPGYAFHPLAAALPAYFAKSATIYNPIIYVFMNRQ 0
0 FRNCILQLFGKKVDDGSEVSTSRTEVSSVSNSSVSPA* 0

>LWS_anoCar Anolis carolinensis (lizard) Deut.Saur.Lepi genomic full Gt OPN1LW long wavelength syn(- - -TEX28 +TKTL1)
0 MAGTVTEAWDVAVFAARRRNDEDDTTRDSLFTYTNSNNTR 1
2 GPFEGPNYHIAPRWVYNITSVWMIFVVIASIFTNGLVLVATAKFKKLRHPLNWILVNLAIADLGETVIASTISVINQISGYFILGHPMCVLEGYTVSTC 1
2 GISALWSLAVISWERWVVVCKPFGNVKFDAKLAVAGIVFSWVWSAVWTAPPVFGWSR 2
1 YWPHGLKTSCGPDVFSGSDDPGVLSYMIVLMITCCFIPLAVILLCYLQVWLAIRA 0
0 VAAQQKESESTQKAEKEVSRMVVVMIIAYCFCWGPYTVFACFAAANPGYAFHPLAAALPAYFAKSATIYNPIIYVFMNRQ 0
0 FRNCIMQLFGKKVDDGSELSSTSRTEVSSVSNSSVSPA* 0

>LWS_xenTro Xenopus tropicalis (frog) Deut.Amph.Anur genomic full Gt OPN1LW long wavelength syn(-IRAK1 -MECP2 - -)
0 MASHWNEAVFAARRRNDDDDTTRSSVFTYTNSNNTR 1
2 GPFEGPNYHIAPRWVYNISSLWMIFVVLASVFTNGLVLVATLKFKKLRHPLNWILVNMAIADLGETVIASTISVCNQIFGYFVLGHPMCILEGYTVSVC 1
2 GIAALWSLTVIAWERWFVVCKPFGNIKFDGKLAATGIIFSWVWAAGWCAPPIFGWSR 2
1 YWPHGLKTSCGPDVFSGSSDPGVQSYMLVLMITCCIIPLAIIVLCYMHVWLTIRQ 0
0 VAQQQKESESTQKAEREVSRMVVVMIIAYIFCWGPYTFFACFAAFNPGYNFHPLAAAMPAYFAKSATIYNPIIYVFMNRQ 0
0 FRNCIYQLFGKKVDDGSEVSSTSRTEVSSVSNSSVSPA* 0

>LWS_neoFor Neoceratodus forsteri (lungfish) Deut.Sarc.Dipn EF526299 17961206 full Gt OPN1LW long wavelength
0 MAEPWDAVLAARRRHQDEETTRSTIFVYTNSNNTR 1
2 GPFEGPNYHIAPRWVYNLTSLWMIFVVFASCFTNGLVLMATYKFKKLRHPLNWILVNLAIADLGETLIASTISVTNQIFGYFILGHPMCMLEGFTVATC 1
2 GITGLWSLTIIAWERWVVVCKPFGNIKFDGKWAAGGIIFSWVWSAFWCAMPLFGWSR 2
1 FWPHGLKTSCGPDVFSGEDKYGTRSFMIALMITCCIIPLGVIILCYIQVWWAIRT 0
0 VAKQQKESESTQKAEKEVSRMVVVMIFAYCFCWGPYTFMACFGAAYPGYAFHPLAAALPAYFAKSATIYNPIIYVFMNRQ 0
0 FRNCIYQLLGKKVDDGSELSSTSKTEVSSVSNSSVSPA* 0

>LWS_danRer Danio rerio (zebrafish) Deut.Acti.Otoc genomic full Gt
0 MAEHWGDAIYAARRKGDETTREAMFTYTNSNNTK 1
2 DPFEGPNYHIAPRWVYNVATVWMFFVVVASTFTNGLVLVATAKFKKLRHPLNWILVNLAIADLGETLFASTISVINQFFGYFILGHPMCIFEGYTVSVC 1
2 GIAALWSLTVISWERWVVVCKPFGNVKFDAKWASAGIIFSWVWAAAWCAPPIFGWSR 2
1 YWPHGLKTSCGPDVFSGSEDPGVQSYMVVLMITCCIIPLAIIILCYIAVYLAIHA 2
0 VAQQQKDSESTQKAEKEVSRMVVVMIFAYCFCWGPYTFFACFAAANPGYAFHPLAAAMPAYFAKSATIYNPVIYVFMNRQ 0
0 FRVCIMQLFGKKVDDGSEVSTSKTEVSSVAPA* 0

>LWS_tetNig Tetraodon nigroviridis (pufferfish) Deut.Acti.Perc genomic full G?
0 MAEEWGKQSFAARRYHEDSTRGSAFVYTNSNHTR 1
2 DPFEGPNYHIAPRWVYNLATLWMFFVVVLSVFTNGLVLVATAKFKKLRHPLNWILVNLAVADLGETLFASTISVCNQFFGYFILGHPMCIFEGYVVSVC 1
2 GIAGLWSLTIISWERWIVVCKPFGNVKFDAKWATAGIVFSWIWPICWCAPPIFGWSR 2
1 YWPHGLKTSCGPDVFSGSEDPGVQSYMIVLMITCCIIPLAIIVLCYLAVWMAIRA 2
0 VAMQQKESESTQKAEREVSRMVVVMILAYCVCWGPYTFFACFAAANPGYAFHPLAAAMPAYFAKSATIYNPIIYVFMNRQ 0
0 FRVCIMKLFGKEVDDGSEVSTSKTEVSSVAPA* 0

>LWS_takRub Takifugu rubripes (fugu) Deut.Acti.Perc genomic full Gt OPN1LW long wavelength
0 MAEEWGKQSFAARRYHEDTTRGSAFVYTNSNHTR 1
2 DPFEGPNYHIAPRWVYNVATVWMFIVVVLSVFTNGLVLVATAKFKKLRHPLNWILVNLAIADLGETVFASTISVCNQFFGYFILGHPMCVFEGYTVSTC 1
2 GIAALWSLTIISWERWVVVCKPFGNVKFDAKWATGGIVFSWVWAAVWCAPPIFGWSR 2
1 YWPHGLKTSCGPDVFSGSEDPGVQSYMIVLMITCCIIPLAIIILCYLAVWLAIRS 0
0 VAMQQKESESTQKAEKEVSRMVVVMIVAYCVCWGPYTFFACFAAANPGYAFHPLAAAMPAYFAKSATIYNPVIYVFMNRQ 0
0 FRVCIMKLFGKEVDDGSEVSTSKTEVSSVAPA* 0

>LWS_gasAcu Gasterosteus aculeatus (stickleback) Deut.Acti.Perc genomic full Gt OPN1LW long wavelength
0 MAEEWGKQAFAARRYNEDTTRGSMFVYTNSNNTK 1
2 DPFEGPNYHIAPRWVYNLSTLWMFIVVALSVFTNGLVLVATAKFKKLQHPLNWILVNLAIADLGETVFASTISVCNQFFGYFILGHPMCVFEGYVVSVC 1
2 GITALWSLTIISWERWIVVCKPFGNVKFDAKWATAGIVFSWIWSAVWCAPPIFGWSR 2
1 YWPHGLKTSCGPDVFSGSEDPGVQSYMIVLMITCCLIPLAIIILCYLAVWLAIRA 0
0 VAMQQKESESTQKAERDVSRMVVVMIVAYIVCWGPYTTFACFAAANPGYAFHPLAAAMPAYFAKSATIYNPVIYVFMNRQ 0
0 FRSCIMQLFGKEVDDGSEVSTsKTEVSSVAPA* 0

>LWS_oryLat Oryzias latipes (medaka) Deut.Acti.Perc genomic full Gt
0 MAEQWGKQVFAARRQNEDTTRGSAFTYTNSNHTR 1
2 DPFEGPNYHIAPRWVYNLATLWMFFVVVLSVFTNGLVLVATAKFKKLRHPLNWILvNLAIADLGETVFASTISVCNQFFGYFILGHPMCVFEGYVVSTC 1
2 GIAALWSLTIISWERWVVVCKPFGNVKFDAKWAIGGIVFSWVWSAVWCAPPVFGWSR 2
1 YWPHGLKTSCGPDVFSGSDDPGVQSYMIVLMITCCIIPLAIIILCYLAVWLAIRA 0
0 VAMQQKESESTQKAEREVSRMVVVMIVAYCVCWGPYTFFACFAAANPGYAFHPLAAAMPAYFAKSATIYNPVIYVFMNRQ 0
0 FRTCIMQLFGKQVDDGSEVSTSKTEVSSVAPA* 0

>LWS1_calMil Callorhinchus milii (elephantfish) Deut.Chon.Holo EF565165 19196633 full G? OPN1LW long wavelength
0 MTQSWELVAPAARRGFKYDEPTHSGIFVYTNSNQTR 1
2 GPFEGPNYHIAPRWAYNLTSVWMVGVVVASVFTNGLVLVATVRFKKLRHPLNWILVNMALADLGETVLASTVSVANQFFGYFILGHPLCVFEGFVVSLC 1
2 GITALWSLTIIAWERWVVVCKPFGNMKFDSKMAVAGIVFSWVWSAGWCLPPIFGWSR 2
1 YWPHGLKTSCGPDVFSGNEDPGVQSYMVALTLSCAVLPLLIIILCYFQVWWAIRA 0
0 VALQQKESESTQKAEKEVSRMVVVMVAAFCLCWGPYACFAMFSALNPGYAFHPLVASIPSYFAKSSTIYNPIIYVFMNRQ 0
0 FRNCILQLFGKKVDDGSELSSTSKTDVSSVSNSSVSPA* 0

>LWS2_calMil Callorhinchus milii (elephantfish) Deut.Chon.Holo EF565166 19196633 full G? OPN1LW long wavelength
0 MAEPRGSVAFAARRWNDHEGTTVGEFTYTNSNSTR 1
2 DPFEGPNYHIAPRWTYNLTSLWMVVVVILSVFTNGLVLVATWKFKKLRHPLNWILVNLAIADLGETLFASTISICNQVFGYFILGHPMCVFEGFTVSAC 1
2 GITALWSLTIIAWERWVVVCKPFGNVKFDGKWAAFGIIFSWVWSIGWCLPPVFGWSR 2
1 YWPHGLKTSCGPDVFSGSSDPGVKSYMVTLVITCAALPLTIIIVCLYQVWLAIRA 0
0 VAMQQKESESTQKAEKEVSRMVVVMIIAFCFCWGPYTSFAVFSALNPGYSFHPLMAALPAYFAKSSTIYNPIIYVFMNRQ 0
0 FRNCILQLFGKKVDDGSELSSTSKTDVSSVSNSSVSPA* 0

>LWS_petMar Petromyzon marinus (lamprey) Deut.Agna.Hype genomic full Gt OPN1LW long wavelength traces key to intron 3 position and gapping
0 MTASWQGAMFAARRRQDDEDTTMESLFRYTNENNTK 1
2 DPFEGPNYHIAPRWVFNLTSVWMIIVVVLSLFSNGLVLVATVKFKKLRHPLNWIIVNLAIADILETIFASTISVCNQVYGYFILGHPMCVFEGYVVSTC 1
2 GIAGLWSLAIISWERWMVVCKPFGNIKFDGKIATILIVFSWVWPASWCSLPIFGWSR 2
1 YWPHGLKTSCGPDVFSGSTDPGVQSYMVVLMITCCFLPLSIIILCYLQVWLAIHS 0
0 VAQQQKESETTQKAERDVSRMVVVMILAYVFCWGPYTFFACFAAANPGYSFHPIAAALPAYFAKGATIYNPIIYVFMNRQ 0
0 FRNCILQLFGKKVDDGSEVSSSSRTEVSSVSNSSVSPA* 0

>LWS_letJap Lethenteron japonicum (lamprey) Deut.Agna.Hype AB116381 15096614 full Gt OPN1LW long wavelength
0 MTASWHGAVFAARRRNDDEDTTKDSIFRYTNENNTR 1
2 DPFEGPNYHIAPRWMFNLTSVWMIIVVVLSLFTNGLVLVATMKFKKLRHPLNWILVNLAIADILETIFASTISVCNQVFGYFILGHPMCVFEGYVVSTC 1
2 GIAGLWSLAIISWERWMVVCKPFGNIKFDGKIAIILIVFSWVWPACWCSLPIFGWSR 2
1 YWPHGLKTSCGPDVFSGSSDPGVQSYMVVLMVTCCFLPLSVIILCYLQVWLAIHS 0
0 VAQQQKESETTQKAERDVSRMVVVMILAYIFCWGPYTFFACYAAANPGYAFHPLTAALPAYFAKSATIYNPVIYVFMNRQ 0
0 FRNCIMQLFGKKVDDGSEVSSASRTEVSSVSNSSISPA*

>LWS_geoAus Geotria australis (lamprey) Deut.Agna.Hype AY366491 17463225 full Gt OPN1LW long wavelength
0 MAQSWERAMFAARRRQDEDTTKGDLFRYTNENNTR 1
2 DPFEGPNYHIAPRWMYNLTSFWMIIVVILSLFTNGLVLVATLKFKKLRHPLNWILVNLAIADIGETIFASTVSVVNQIFGYFILGHPLCVFEGFTVSVC 1
2 GITALWSLAIISFERWMVVCKPFGNLKFDGKVAIVLIIFSWAWSAGWCAPPIFGWSR 2
1 YWPHGLKTSCGPDVFSGSTDPGVQSYMVVLMITCCFIPLALIIICYLQVWLAIHT 0
0 VAQQQKESETTQKAERDVSRMVVVMIFAYIFCWGPYTFFACFAAANPGYAFHPLAAALPAYFAKSATIYNPIIYVFMNRQ 0
0 FRNCIMQLFGKKVDDGSEVSSSARTEVSSVSNSSVSPA* 0

>PIN_galGal Gallus gallus (chicken) Deut.Saur.Arch genomic full Gt pinopsin pineal non-visual
0 MSSNSSQAPPNGTPGPFDGPQWPYQAPQSTYVGVAVLMGTVVACASVVNGLVIVVSICYKKLRSPLNYILVNLAVADLLVTLCGSSVSLSNNINGFFVFGRRMCELEGFMVSLT 1
2 GIVGLWSLAILALERYVVVCRPLGDFQFQRRHAVSGCAFTWGWALLWSTPPLLGWSSYVPE 1
2 GLRTSCGPNWYTGGSNNNSYILSLFVTCFVLPLSLILFSYTNLLLTLRA 0
0 AAAQQKEADTTQRAEREVTRMVIVMVMAFLLCWLPYSTFALVVATHKGIIIQPVLASLPSYFSKTATVYNPIIYVFMNKQ 0
0 FQSCLLEMLCCGYQPQRTGKASPGTPGPHADVTAAGLRNKVMPAHPV* 0

>PIN_taeGut Taeniopygia guttata (finch) Deut.Saur.Arch genomic full G? pinopsin
0 MDSTQEPPNSSTPGPFDGPQWPHQAPRATYLVVAVLMGLVVASASLLNGLVIVVSVRHKRLRSPLNYILLNLAVANLLVTLCGSSVSLSNNISGFFVFGERLCQLEGFMVSLT 1
2 GIVGLWSLAILALERYLVVCRPLGDFRFQQQHAASGCAFTWGWSLLWTTPPLLGWSSYVPE 1
2 GLRTSCGPNWYTGGSNNSSYILALFVTCFVMPLSLILFSYTNLLLTLRA 0
0 AAARQQESDTTQQAEREVTRMVVAMVVAFLTCWLPYATFALVVATHKDIVIQPALASLPSYFSKTATVYNPIIYVFMNKQ 0
0 SCLLGMLCCGHHPRGMGKTSPAAPSPQVAAEGLRNKVTPSHPV* 0

>PIN_colLiv Columba livia (pigeon) Deut.Saur.Arch CLU50598 8982090 full G? pinopsin
0 MDPTNSPQEPPHTSTPGPFDGPQWPHQAPRGMYLSVAVLMGIVVISASVVNGLVIVVSIRYKKLRSPLNYILVNLAMADLLVTLCGSSVSFSNNINGFFVFGKRLCELEGFMVSLT 1
2 GIVGLWSLAILALERYVVVCRPLGDFRFQHRHAVTGCAFTWVWSLLWTTPPLLGWSSYVPE 1
2 GLRTSCGPNWYTGGSNNNSYILTLFVTCFVMPLSLILFSYANLLMTLRA 0
0 AAAQQQESDTTQQAERQVTRMVVAMVMAFLICWLPYTTFALVVATNKDIAIQPALASLPSYFSKTATVYNPIIYVFMNKQ 0
0 FQSCLLKMLCCGHHPRGTGRTAPAAPASPTDGLRNKVTPSHPV* 0

>PIN_utaSta Uta stansburiana (lizard) Deut.Saur.Lepi DQ100321 16543463 full Gt pinopsin missing genome
0 MVNEWSNATPGPFDGPQWPYLAPRSIYTSVAVLMGLVVVSAAFVNGLVIVVSIQYKKLRSPLNYILVNLAIADLLVTSFGSTLSFANNIYGFFVLGQTACEFEGFMVSLT 1
2 GIVGLWSLAILAFERYLVICKPVGDFRFQQRHAVFGCVFTWMWSLVWTLPPLFGWSSYVPE 1
2 GLRTSCGPNWYTGGSGNNSYIMALFVTCFALPLGMIIFSYASLLLTLRA 0
0 VATQQKEVETTQQAEKEVTRRVIAMVMAFLVCWLPYASFAMVVATNKDLVIQPALASLPSYFSKTATVYNPIIYVFMNKQ 0
0 FRSCLLSTMSCGHRPRGAQETTPAMISIPQGPTSALQGSRNKVTPSASEGSGNEAIPS* 0

>PIN_pheMad Phelsuma madagascariensis (gecko) Deut.Saur.Lepi AB022881 full Gt pinopsin no_ref AB022881
0 MHVQMANASQASLKNGTLSPFDGPQWPHRASRRVYTSLAALMGVVVLSASLANGLVIAVSVRFKRLRSPLNYILVNLATADLLVTFFGSIISFVNNAVGFFVFGKTACRFEGFMVSLT 1
2 GIVGLWSLAILAFERYLVICKPVGDFQFQRRHAVIGCLYTWGWSLIWTVPPLFGWSSYVPE 1
2 GLGTSCGPNWYMGGTNNNSYIVALFVTCFALPLSMILFSYANLLLTLRA 0
0 VAAQQKEQETTQRAEKEVTRMVITMVMAFLVCWLPYATFAMVVATTKDLSIQPGLASLPSYFSKTATVYNPIIYVFMNKQ 0
0 FRSCLLNTVSCGRIPQTMPGTPATTAVRGGFVLTSEGRGNKVASTELHS* 0

>PIN_podSic Podarcis sicula (lizard) Deut.Saur.Lepi DQ013042 16688437 full Gt pinopsin
0 MQASNASWVEVRNRTPGPFEGPQWPYLAPQSTYISVAVLMGLVVISATLVNGLVIVVSVQFKKLRSPLNYVLVNLAVADLLVTFFGSTISFVNNAQGFFIFGQATCEFEGFMVSLT 1
2 GIVGLWSLAILAFERYLVICKPVGDFRFPARHAVLGCAFTWGWSFVWTVPPLLGWSSYVPE 1
2 GLRTSCGPNWYSGGSSNNSYIMTLFVTCFAMPLSTILFSYANLLMTLRT 0
0 VAAQQKEQETTQRAEREVTRMVVAMVAAFLVCWLPYASFAMVVATHKDLAIRPALASLPSYFSKTATVYNPIIYVFMNKQ 0
0 FRSCLLYKMSCGHRALSSQDTTPAGISLPGRLTTSASKGSRNQVSPS* 0

>PIN_xenTro Xenopus tropicalis (frog) Deut.Amph.Anur genomic full Gt pinopsin
0 MRAGNMSAYEAPGPYDGPQWPHLAPRSTFLTVAAVMCMVVILAFFVNGLVIVVTLKYKKLRSPLNYILVNLAIANLLVTIFGSSVSFSNNVVGYFFMGKTMCEFEGFMVSLT 1
2 GIVGLWSLAILAFERYLVICKPMGDFRFQQKHAILGCSFTWVWSFIWTSPPLFGWCSYVPE 1
2 GLRTSCGPNWYTGGTNNNSYIMALFLTCFIMPLSTIIFSYSNLLMALRA 0
0 VAAQQKDSETTQRAEKEVTRMVIAMVLAFLICWLPYASFAVVVAVNKDVVIEPTVASLPSYFSKTATVYNPIIYVFMNKQ 0
0 FRNCLMTLLCCGRSFGDDETSSASGRTDVTSVSEAGGNKVTPA* 0

>PIN_bufJap Bufo japonicus (toad) Deut.Amph.Anur AF200433 9537517 full Gt pinopsin classifies oddly
0 MHSANMSALETPGPFEGPQWPHVAPRSTYLTVAVLMGMVVFLAFFVNGMVIVVSLKYKKLRSPLNYILVNLAVADILVTMFGSTVSFHNNIFGFFTLGKLVCELEGFVVSLT 1
2 GIVGLWSLAILAFERYIVICKPMGDFRFQQRHAVMGCAFTWIWAFLWTSPPLIGWCSYVPE 1
2 GLGTSCGPNWYTGGTNNNSYILALFTTCFMMPLTTIIFSYSNLLLALRA 0
0 VAAQQKESETTQRAEREVTRMVIAMVLAFLICWLPYAVFAIVMASNKNVVIDPTLASMPSYFSKTATVYNPVIYVFMNKQ 0
0 FRDCLTKLLCCGRNPFGEDETSTTSGRTDVTSVSEGGGNKVTPA* 0

>PIN_calMil Callorhinchus milii (elephantfish) Deut.Chon.Holo genomic frag Gt pinopsin
0  FGSTVSFSNNINGYFVLGETVCQFEGFMVSLT 1
2 GIVGLWSLAILAFERYIVICKPMGDFRFQQKHAVWGCLFTWLWSLFWTLPPLFGWCSYVPE 1
2 GLRTSCGPNWYTGGANNSSYVVALFITCFTLPLSLIIFSYASLLVVLRA 0

>VAOP_galGal Gallus gallus (chicken) Deut.Saur.Arch genomic 19664923 full Gt vertebrate ancient opsin exon 1 genbank error new stop *RKNGDEH
0 MDVFRALGNESLLSNSSGPARWDPFHHPLDSIQPWHFRLVAAVMFVVTSLSLAENLAVILVTFKFKQLRQPVNYVIVNLSVADFLVSLTGGTISFLANLKGYFYMGHWACVLEGFAVTFF 1
2 GIVALWSLALLAFERYIVICRPVGNMRLRGKHAAQGIAFVWTFSFIWTIPPTMGWSSYTTSKIGTTCEPNW 2
1 YSGAYNDRSYIIAFFTTCFIVPLLVILVSYGKLLQKLRK 0
0 VSNTQGRLRTARKPERQVTRMVVVMIIAFLICWMPYAVFSILATAYPSIELDPHLAAIPAFFSKTATVYNPIIYVFMNKQ 0
0 FRMCLIQMFKCSAIETAESNMNPTSERATLTQDKRDSQLSVMAVRSTIS* 0

>VAOP_taeGut Taeniopygia guttata (finch) Deut.Saur.Arch genomic full G? vertebrate ancient opsin last exon newly truncated
0 MHLEYLKMGHFCPVTLLLPDGDPFHRPLDSIQPWQFKLLAAVMLLVTSLSLAENLAVILVTFKFKQLRQPINYIIVNLSVADFLVSLTGGTISFLTNLKGYFFMGYWACVLEGFAVTFF
2 GIVALWSLALLAFERYIVICRPLRNARLRGKHAALGIVFVWSFSFIWTIPPTTGWSSYTTSKIGTTCEPNW 2
1 YSGAYADHTYIITFFTTCFIVPLLVILVSYGKLVWKLKK 0
0 VSDAQGRLGAARRPERQVTRMVVFMIVAFLICWMPYATFSILVTAYPSIELDPCVAAIPAFFSKTATVYNPVIYVFMNKQ 0
0 FRQCLIQMFSCSAIGTAESNMKLTSERAVLMQGRRGSKRTPMAVHSTVLKRKTGDEHRADDLWLF* 0

>VAOP_anoCar Anolis carolinensis (lizard) Deut.Saur.Lepi genomic full Gt vertebrate ancient opsin syn(+INPP5A -NXK6 +GPR125 +KNDC1)
0 MAGLRREAENDSWLFDPSSSSAPFDPFLQPLDIIEPWNFHLISALMFVVTLFSLSENFTVILVTIKFKQLRQPLNYVIVNLSVADFLVSLIGGTISFSTNLKGYFYMGHWACVLEGFAVTFF 1
2 GIVALWSLALLAFERYVVICRPLGNMRLNGKHAALGVAFVWIFSFIWTVPPTMGWSSYTTSKIGTTCEPNW 2
1 YSGDYNDHTFIITFFTTCFILPLLVILVSYGKLMRKLRK 0
0 VSDTQGRLGTTRKPERQVTGMVVIMILAFLICWSPYAAFSILVTACPSIELDPRLAAIPAFFSKTATVYNPVIYVFMNNQ 0
0 FRKCLVQLFQCSSQETMDANVNPISEKDTLTHTKHCGEMSTVAAHVIVFNPRSEDEQGSCQSFAQLAISENKVYPL* 0

>VAOP_xenTro Xenopus tropicalis (frog) Deut.Amph.Anur genomic full Gt vertebrate ancient opsin syn(- +GSTO2 -C10orf92 -) new
0 MPTNVSLLATPENSTVWNPFTGPLKTIEAWNFHLLAALMFVVTSLSIAENFIVILVTAKFKQLRQPLNYIIVNLSVADFLVSVIGGTISIATNSRGYFYLGSWACVLEGFAVTFF 1
2 GIVALWSLSVLAFERYIVICRPLGNLRLQGKHSALAIIFVWVFSFVWTIPPTMGWSSYTTSKIGTTCEPNW 2
1 YSGEMRDHTYIITFLTTCFVFPLLVIFMSYGKLMRKLRK 0
0 VSDTQGRLGSTRKPEKEVTRMVVIMILAFLICWTPYAAFSILITAHPTIDLDPRLAAIPAFFAKTASMYNPIIYVYMNKQ 0
0 FRRCLYQMFNINDPEAKESNLNPTSERGVLTRNNNGGEMLAIATHITSSAVTNREEEKSSSNSFAHIPVSDNKVCPM* 0

>VAOP_danRer Danio rerio (zebrafish) Deut.Acti.Otoc NM_131586 17067577 full Gt valop assembly missing exon 3
0 MEASSAAVNAVSPAEDPFSAPLSSIAPWNYSVLAALMFVVTALSLSENFTVMLVTFRFQQLRQPLNYIIVNLSLADFLVSLTGGSISFLTNYHGYFFLGKWACVLEGFAVTFF 1
2 GIVALWSLAVLAFERFFVICRPLGNIRLRGKHAALGLVFVWSFSFIWTVPPVLGWSSYTVSRIGTTCEPNW 2
1 YSGNFHDHTFIITLFSTCFIFPLGVIIVCYCKLIRKLRK 0
0 VSNTHGRLGNARKPERQVTRMVVVMIVAFMVAWTPYAAFSIIITAHPSMHVDPRLAAIPAFVAKTAAVYNPIIYVFMNKQ 0
0 FRKCLVQLLSCSKVTVVEGNNNQTTERAGMTSGSNTGEMSAIAARVSVPKTEENPGDRSTFSHIPIPENKVCPM* 0

>VAOP_tetNig Tetraodon nigroviridis (pufferfish) Deut.Acti.Perc genomic full G? vertebrate ancient opsin syn(INPP5A NKX6 +VAOP GABRP KNDC1)
0 MESLSLSVNGVSHTVAAELAPTNDPFSGPINNIAQWNFTILAVLMFVVTALSLSENFLVMFITFKFKQLRQPLNYIIVNLAIADFLVSITGGLISFLTNARGYFFLGRWACVLEGFAVTYF 1
2 GIVAMWSLAVLSFERFFVICRPLGNMRLQAKHAVIGLLFVWTFSFVWTFPPVLGWNRYTVSKIGTTCEPDW 2
1 YSNNMTSHSYIITFFVTCFILPLGVIFFCYGKLLRKLRK 0
0 VSHGRLATARKPERQVTRMVVVMIVAFMVAWTPYATFAILVTIYPTIELDPRLASIPAFFSKTAAVYNPIIYVFMNKQ 0
0 FRKCLMQHFIGGGGTIESNMNPTSERPGITADSHTGEMSAIAARVPVGASASPLSDDSPTAQLPIPENKVCP* 0

>VAOP_takRub Takifugu rubripes (fugu) Deut.Acti.Perc genomic full Gt vertebrate ancient opsin syn(+INPP5A -NXK6 - +KNDC1)
0 MESLSLSVNGVSYTVAAELAPTNDPFTGPINNIAQWNFTILAVLMFVVTSLSLCENFLVMFITFKFKQLRQPLNYIIVNLAIADFLVSLTGGLISFLTNARGYFFLGRWACVLEGFAVTYF 1
2 GIVAMWSLAVLSFERFFVICRPLGNMRLQAKHAAIGLLFVWTFSFVWTFPPVLGWNRYTVSKIGTTCEPDW 2
1 YSNNMTSHSYIITFFSTCFILPLGIIFFCYGKLLRKLRK 0
0 VSHGRLATARKPERQVTRMVVVMIVAFMVAWTPYATFAILVTIHPTIELDPRLASIPAFFSKTAAVYNPIIYVFMNKQ 0
0 FRKCLIQHFIGMGVMAESNMNPTSERPGITAESQTGEMSAIAARVPVGATAALHSDGSPTDCGSLAQLPIPENKVCPI* 0

>VAOP_gasAcu Gasterosteus aculeatus (stickleback) Deut.Acti.Perc genomic full Gt vertebrate ancient opsin
0 MDTLSLSVNAVSHTVAAELPATSDPFNGPIKNIAPWNFTILAVLMFVVTSLSLSENFLVMFVTFKYKQLRQPLNYIIVNLAIADFLVSLTGGVISFLTNARGYFFLGKGACVLEGFAVTFF 1
2 GIVALWSLAVLSFERFFVICRPLGNIRLQPKHAILGLLFVWTFSFIWTFPPVLGWNRYTISKIGTTCEPDW 2
1 YSTNMIDHSYIITFFATCFILPLGVIFFCYGKLLRKLRK 0
0 VSHGRLATAKKPERQVTRMVVVMIVAFMVGWTPYAVFSLLVTSHPSIKLDPRLASIPAFFSKTAAVYNPIIYVFMNKQ 0
0 FRKCLIQLFSGRGTIPDGHLDPTSERPGMSQTGEMSAIATRIPMSSTVSPRSDDSPTDCVSFAQLPIPENKVCPM* 0

>VAOP_oryLat Oryzias latipes (medaka) Deut.Acti.Perc NM_001136515 full Gt vertebrate ancient opsin DK020629 brain DK098095 embryo
0 MDSLSLSVNAVSFTVATEIFSTDDPFTGPIKNIAPWNFTVLAVLMFVITSLSLTENFLVMFVTFKFKQLRQPLNYIIVNLAIADFLVSLTGGLISFLTNARGYFFLGKWACILEGFAVTFF 1
2 GIVALWSLAVLSFERFFVICRPLGNIRLQSKHAMLGLLFVWTFSFIWTFPPVLGWNRYTVSKIGTTCEPDW 2
1 YSTNMSDHSYIITFFATCFILPLGVIFYCYGRLLRKLRKVS 0
0 VSHGRLATARKPERQVTRMVVVMIVAFMVGWTPYAVFSILVTAHPTIKLDPRLASIPAFFSKTAAVYNPIIYVFMNKQ 0
0 FRKCLIQHFTGMGTIPESNLNQTSERPGITAESHTGEMSAIAARIPMGGTTSPRSDDSQTDCGSFAQLPIPENKVCPL* 0

>VAOP_salSal Salmo salar (salmon) Deut.Acti.Salm NM_001123626 9136902 frag Gt vertebrate ancient opsin first VAOP seq, last exon wrong AF001499
0 MDTLRIAVNGVSYNEASEIYKPHADPFTGPITNLAPWNFAVLATLMFVITSLSLFENFTVMLATYKFKQLRQPLNYIIVNLSLADFLVSLTGGTISFLTNARGYFFLGNWACVLEGFAVTYF 1
2 GIVAMWSLAVLSFERYFVICRPLGNVRLRGKHAALGLLFVWTFSFIWTIPPVFGWCSYTVSKIGTTCEPNW 2
1 YSNNIWNHTYIITFFVTCFIMPLGMIIYCYGKLLQKLRK 0
0 VSHDRLGNAKKPERQVSRMVVVMIVAYLVGWTPYAAFSIIVTACPTIYLDPRLAAAPAFFSKTAAVYNPVIYVFMNKQ 0

>VAOP_pleAlt Plecoglossus altivelis (smelt) Deut.Acti.Salm AB074483 11779166 full Gt vertebrate.ancient.opsin brain and amacrine cells of retina
0 MDTLRIPVNGVSYTEATEILKPEDPFTGPLSNIAPWNFTFLAVLMFFVSFLSLCENFTVMFVTFKFKQLRQPLNYIIVNLSIADFLVSLSGGLISFLTNAKGYFFLGKWACVLEGFAVTYF 1
2 GIVAMWSLAVLSFERFFVICRPLGNIRLRGKHAVLGLLFVWTFSFIWTIPPVLGWSSYTVSKIGTTCEPNW 2
1 YSTKLSDHIYIITFFFTCFILPLGVIIFCYGKLLRKLRK 0
0 VSHGRLGNARKPERQVTRMVVVMIVAFMVGWTPYAAFSIVVTACPHIYIDPRMAAIPAFFSKTAACYNPVIYVFMNKQ 0
0 FRKCLIKLFTGKGTIPEGNLGQTSERPGMTAESQTGEMSAIAARIPVGGTAATKSDEQPSECNSFAQLPIPENKVCPI* 0

>VAOP_rutRut Rutilus rutilus (minnow) Deut.Acti.Otoc AY116411 12906786 full Gt vertebrate ancient opsin
0 MELFPVAVNGVSHAEDPFSGPLTFIAPWNYKVLATLMFVVTAASLSENFAVMLVTFRFTQLRKPLNYIIVNLSLADFLVSLTGGTISFLTNYHGYFFLGKWACVLEGFAVTYF 1
2 GIVALWSLAVLAFERFFVICRPLGNIRLRGKHAALGLLFVWTFSFIWTIPPVLGWSSYTVSKIGTTCEPNW 2
1 YSGNFHDHTFIIAFFITCFILPLGVIVVCYCKLIKKLRK 0
0 VSNTHGRLGNARKPERQVTRMVVVMIVAFMVAWTPYAAFSIVVTAHPSIHLDPRLAAAPAFFSKTAAVYNPVIYVFMNKQ 0
0 FRKCLVQLLRCRDVTIIEGNINQTSERQGMTNESHTGEMSTIASRIPKDGSIPEKTQEHPGERRSLAHIPIPENKVCPM* 0

>VAOP_cypCar Cyprinus carpio (carp) Deut.Acti.Otoc AF233520 -------- full Gt vertebrate.ancient.opsin ---
0 MESLAAAVNGVSHTEDPFSGPLSSIAPWNYRVLAALMFVVTSVSLCENFTVMLVTFRFKQLRQPLNYIIVNLSLADFLVSLSGGTISFLTNFHGYFFLGRWACVLEGFAVTF 1
2 FGIVALWSLAVLAFERFFVICRPLGNIRLRGKHAALGLLFVWSFSFVWTIPPVLGWSSYTVSKIGTTCEPNW 2
1 YSGNFQDHTFIITFFTTCFIFPLAVIIVCYCKLLRKLRK 0
0 VSNTHGRLGNARKPERQVTRMVVVMIVAFMVAWTPYAAFSIVVTALPSIHLDPRLAAAPAFFSKTAAVYNPIIYVFMNKQ 0
0 FRKCVVQLLSCRDVTVVEGNINQTTDRAGLTNESNTGEMSAIAARIPAAGTVPPKTEEPPNERSSFTQIPIPENKVCPM* 0

>VAOP_ictPun Ictalurus punctatus (catfish) Deut.Acti.Otoc FJ839436 -------- full Gt vertebrate.ancient.opsin ---
0 MGSFGTAVRGVNYTEAADVIQPEDPFSGPVKSIAPWNFKVLAAWMVVITSLSLSENFLVMLVTYKFKQLRQPLNFLIVNLSLADFFMSLIGGTLSVVTNYRGYFFLGSWACVLEGFAVTF 1
2 FGIVGMWSLATLAFERYFVICRPLGNVRLQVKHAVLGLLFVWTFSFIWTIPPVLGWSSYTVSKIGTTCEPNWYSGDPHDHTFIITFFLTCFILPLAVIIVCYSKLLRKLRK 0
0 VSNSHGRLVNARKPDRQVSHMVVVMIVAFVVAWTPYALFSFIVTVHPTIYLDPIMAAVPAFFAKTAAVYNPIIYVFMNKQ 0
0 FRKCLIQLLSCSGNTTVEVNQSTDRAGMIGESNTGEMSAIAARIPAASTTSPPKANEQHSNSCSYSQLPIPENKVCPM* 0

>VAOP_calMil Callorhinchus milii (elephantfish) Deut.Chon.Holo genomic frag Gt vertebrate ancient opsin
0 VASTQGRLGVARKPEKQVTRMVIVMILAFLFCWTPYAAFSITVTACPTIKLDPRLAAIPAFFSKTATVYNPIIYVFMNKQ 0

>VAOP_petMar Petromyzon marinus (lamprey) Deut.Agna.Hype U90667 9427550 full Gt vertebrate ancient opsin exons 123 in traces pineal gland-specific
0 MDALQESPPSHHSLPSALPSATGGNGTVATMHNPFERPLEGIAPWNFTMLAALMGTITALSLGENFAVIVVTARFRQLRQPLNYVLVNLAAADLLVSAIGGSVSFFTNIKGYFFLGVHACVLEGFAVTYF 1
2 GVVALWSLALLAFERYFVICRPLGNFRLQSKHAVLGLAVVWVFSLACTLPPVLGWSSYRPSMIGTTCEPNW 2
1 YSGELHDHTFILMFFSTCFIFPLAVIFFSYGKLIQKLKK 0
0 ASETQRGLESTRRAEQQVTRMVVVMILAFLVCWMPYATFSIVVTACPTIHLDPLLAAVPAFFSKTATVYNPVIYIFMNKQ 0
0 FRDCFVQVLPCKGLKKVSATQTAGAQDTEHTASVNTQSPGNRHNIALAAGSLRFTGAVAPSPATGVVEPTMSAAGSMGAPPNKSTAPCQQQGQQQQQQGTPIPAITHVQPLLTHSESVSKICPV* 0

>PPIN_anoCar Anolis carolinensis (lizard) Deut.Saur.Lepi genomic full Gt parapinopsin syn(-CPEB2 -CACNA2D3 +SELK) syntenic deleted chicken
0 MDSLDTNTLSPNASTVRVVLMPRIGYTIIAIIMATSCTLSVILNTAVIAITIKYRQLRQPINYSLVNLAIADLGAALLGGSLNVETNAVGYYNLGRVGCVTEGFAMAFF 1
2 GIVALCTIAVIAVDRAIVIAKPMGTITFTTRKAMIGVAVSWIWSLVWNTPPLFGWGGYQMEGVMTSCAPDWANSDPINVSYIICYFLFCFTIPFITILASYGYLIWTLRQ 0
0 VAKVGLAQRGSTTKAEAQVSRMVIVMVMAFLICWLPYATFALVVVGNPQIYINPIIATIPMYMAKSSTFYNPIIYIFMNKQ 0
0 FRDCLVRCLLCGRNPCASEQTDEDDLEVSTIAPAPSSRRGKVAPV* 0

>PPIN_xenTro Xenopus tropicalis (frog) Deut.Amph.Anur genomic full Gt parapinopsin para bistable UV lamprey pineal broken contigs
0 MADEALLPPMMNVTNEEMHPGKVLMPRIGYTILALIMAVFCAAALFLNVTVIVVTFKYRQLRHPINYSLVNLAIADLGVTVLGGALTVETNAVGYFNLGRVGCVIEGFAVAFF 1
2 GIAALCTIAVIALDRVFVVCKPMGTLTFTPKQALAGIAASWIWSLIWNTPPLFGWGSYELEGVMTSCAPNWYSADPVNMSYIVCYFSFCFAIPFLIIVGSYGYLMWTLRQ 0
0 VAKLGVAEGGTTSKAEVQVSRMVIVMILAFLVCWLPYAAFAMTVVANPGMHIDPIIATVPMYLTKTSTVYNPIIYIFMNKQ 0
0 FQECVIPFLFCGRNPWAAEKSSSMETSISVTSGTPTKRGQVAPA* 0

>PPIN_danRer Danio rerio (zebrafish) Deut.Acti.Otoc XM_681591 full Gt parapinopsin syn(- - +SELK -)
0 MESETSTAASGSIAEVMPRMGYTILAVIIGVFSVCGVILNVTVITVTLKYKQLRQPLNFALVNLAVADLGCAVFGGLPTVVTNAMGYFSLGRVGCVLEGFAVAFF 1
2 GIAALCSVAVIALERCMVVCRPVGSISFQTRHAVFGVAVSWLWSFIWNTPPLFGWGRLQLEGVRTSCAPDWYSRDLANVSFIVCYFLLCFALPFSVIVYSYTRLLWTLRQ 0
0 VSRLQVCEGGSAARAEAQVSCMVVVMILAFLLTWLPYASFALCVILIPELYIDPVIATVPMYLTKSSTVFNPIIYIFMNRQ 0
0 FRDRALPFLLCGRNPWAAEAEEEEEETTVSSVSRSTSVSPA* 0

>PPINa_tetNig Tetraodon nigroviridis (pufferfish) Deut.Acti.Perc genomic full G? parapinopsin
0 MKPSVYLNTSLYLGPPEEPPLPRSGFIVLSILMALVTGPAIVLNATVIIVSLMHKQLRQPLNYALVNMAAADLGTAVSGGLLSVVNNAQGHFSLGRTGCVLEGFAVSLC 1
2 GIASLCTVALIAVERMFVICKPLGQMQFQKQHALAGISLSWLWSLTWNLPPLFGWGRYELEGVGTSCAPDWQSREPHNVSYVLAYFTVCFAAPFAIILVSYAKLMWTLHK 0
0 VTKMTCLEGGAVAKSEMKVAYMVVLMVATFLLSWLPYAGLSMLVVFKPDVEINPLVGTVPVYLAKSSTAYNPIIYIYLNKQ 0
0 FRKYALPFLLCRRALEAEDEVSETTVESSRRVSPS* 0

>PPINa_takRub Takifugu rubripes (fugu) Deut.Acti.Perc genomic full G? parapinopsin
0 MKPSAFYLNASLYLGPQGEPPLPRSGFIALSVIMALLTGPAIVLNATVIIVSLMHKQLRQPLNYALVNMAVADLGTAMTGGLLSVVNNAQGYFSLGRTGCVLEGFAVSLC 1
2 GIASLCTVALIAVERMFVICKPLGQMQFQKQHALGGIALAWLWSLTWNLPPLFGWGRYELEGVGTSCAPDWHSREPQNVSYVLAYFTVCFAAPFVIILVSYSKLMWTLHK 0
0 VTKMACMEGGAVAKSEMTVAYMVILMVVIFLISWLPYAGLSMLVVLSPDVKIHPLVGTVPVYLAKSSTVYNPIIYIYLNKQ 0
0 FRKYAVPFLLCGRELEMEDELSMTTVETSNRVSPA* 0

>PPINa_gasAcu Gasterosteus aculeatus (stickleback) Deut.Acti.Perc DN691174 full G? parapinopsin adult eyes
0 MQPSHTFSNSSAYTGPHGEPPLSRTGFIILSIIMAGFTGPAIVLNATVIIVTLMHKQLRQPLNYALVNMALADLGTAMTGGVLSVVNNAQGYFSLGRSGCVMEGFAVSLF 1
2 GITSLCTVALIAVERMFVVCKPLGQIIFQKKHAVGGIAISWLWSLSWNLPPLFGWGRYELEGVGTSCAPDWHNQDPKNVSYIVAYFAVCFAVPFALILASYTKLMWTLHQ 0
0 VSKMTCLEGGAVAKGEMKVASMVVLMVLTFLISWLPYASLAMLVVYNPKVEIHALVGTVPVYLAKSSTVFNPIIYIYLNKQ 0
0 FRKYAVPFLLCCKEPLDDEEASEAATTVEISPSKVSPA* 0

>PPIN_ictPun Ictalurus punctatus (catfish) Deut.Acti.Otoc genomic full Gt parapinopsin index sequence
0 MASIILINFSETDTLHLGSVNDHIMPRIGYTILSIIMALSSTFGIILNMVVIIVTVRYKQLRQPLNYALVNLAVADLGCPVFGGLLTAVTNAMGYFSLGRVGCVLEGFAVAFF 1
2 GIAGLCSVAVIAVDRYMVVCRPLGAVMFQTKHALAGVVFSWVWSFIWNTPPLFGWGSYQLEGVMTSCAPNWYRRDPVNVSYILCYFMLCFALPFATIIFSYMHLLHTLWQ 0
0 VAKLQVADSGSTAKVEVQVARMVVIMVMAFLLTWLPYAAFALTVIIDSNIYINPVIGTIPAYLAKSSTVFNPIIYIFMNRQ 0
0 FRDYALPCLLCGKNPWAAKEGRDSDTNTLTTTVSKNTSVSPL* 0

>PPIN_oncMyk Oncorhynchus mykiss (trout) Deut.Acti.Salm genomic full Gt parapinopsin
0 MDHQQLLPNLHGNISSSPGSVSEALLSRTGFTILAVIIGVFSVSGVCMNVLVIMVTMRHRKLRQPLNYALVNLAVADLGCALFGGLPTMVTNAMGYFSMGRLGCVLEGFAVAFF 1
2 GIAGLCSVAVIAVDRYVVVCRPMGAVMFQTRHAVGGVVLSWVWSFLWNTPPLFGWGSFELEGVRTSCSPNWYSREPGNMSYIILYFLLCFAIPFSIIMVSYARILFTLHQ 0
0 VSKLKVLEGNSTTRVEIQVVRMVVVMVMAFLLSWLPYAAFALSVILDPSLHINPLIATVPMYLAKSSTVYNPIIYVFMNRQ 0
0 FRDCAVPFLLCGLNPWASEPVGSEADTALSSVSKNPRVSPQ*

>PPINb_takRub Takifugu rubripes (fugu) Deut.Acti.Perc genomic full G? parapinopsin syn(+PCTK1 -PPIN +DDX20 -KCND2) absent medaka zfish
0 MEQGIQEGNSSSLSSVSSGTLSRTGYTVLAFIMGVLSAGGIILNVLVIVVTMKHRQLRQPLSYALVNLAICDLGCALFGGIPTTITSAMGYFSLGRVGCVLEGFAVAFF 1
2 GIASLCTIGVISVERYVVVSNPMGAVLFQTR 2
1 HAVAGVVFSWVWSFVWNTPPLFGWGSFDLEGVRTSCAPNWYSRDVGIMSYIVIYLLFCFAVPFTIITVSYSRLLWTLRQ 0
0 VTGLQVAEGGSTNRVEVQVARMVVVMVLAFLLTWLPYAAMALAVVMDSTLYINPIIATIPVYLAKSSTVYNPIIYIFMNRQ 0
0 FRGCAINTVLCGRRAWITDLQTSEGETTVASTSKSQKISPKGSLN* 0

>PPINb_tetNig Tetraodon nigroviridis (pufferfish) Deut.Acti.Perc genomic full G? parapinopsin syn(-PPIN +DDX20)
0 MEQEIQDGNSSSLNSVSPGILSQTGFTVLAFIMGMLSVGGIILNVLVIVVTLKHRQLRQPLNYALVNLAICDLGCALFGGIPTTVTSAMGYFSLGRLGCVLEGFAVAFF 1
2 GIASLCTIGIISVERYIVVSNPMGAVLFQTR 2
1 HAVAGVVFSWVWSFVWNTPPLFGWGSFELEGVGTSCAPNWYSRDMGNMSYIIIYLLFCFAVPFSIIMVSYSRLLWTLHQ 0
0 VTKLHVAEGGSTNRVEVHVARMVVLMVLAFLLTWLPYASMALAVVMDSTLYIDPVTATIPVYLAKSSTVYNPIIYIFMNRQ 0
0 FRGYAINTILCGRRAWVSEQQTSEGETTVVSVSKSQKISPKGSLQ * 0

>PPINb_gasAcu Gasterosteus aculeatus (stickleback) Deut.Acti.Perc DW621258 full G? parapinopsin syn(+DNMT2 -PPIN +DDX20 -TAZ) 21 day old larvae
0 MERDGNASADAQLLSPSGYAALAAVMGAFSVAGILLNALVIVVTARHRQLRQPLSYALVNLAVCDLGCAACGGLPTTVTSAMGYFSLGRAGCVLEAFAVAFF 1
2 GIASLCTIGVISVERYVVVCYPMGAVLFQTR 1
2 HAVAGVVLSWVWSFVWNTPPLFGWGSYELEGVKISCAPNWYSRDPGNVSYVTIYFLLCFAVPFSVIMVSYSRLLWTLRQ 0
0 VTKLQVSETGSTNRVEVQVARMIVVMVLAFLVTWLPYAAMALAVITDSTLHIDPVIATIPVYLAKSSTVYNPIIYIFMNRQ 0
0 FRGYAVPSILCGWNPWAEEQTSEEETVGSVMKSQRVSPKGSLQE* 0

>PPINb_mayZeb Maylandia zebra (cichlid) Deut.Acti.Perc genomic frag G? parapinopsin
0 1
2 GIASLCTVAVISVERYVVVCYPMGAVLFQTR 2
1 HAVAGVVLSWVWSFVWSTPPLFGWGTFELEGVKTSCAPKWHSRDVGDMSYMIIFFFLCFALPFSVVMVSYSRLLWTLRQ 0
0 GMIVVMVLAFLVTWLPYAALALAVMIDSSLYVDPVIATIPVYFAKSSTVYNPIIYIFMNRQ 0
0 FRGYTVAAVLCGWDPWSSEPQTSENETTVPFFIKTPKKIVPKKSLE*0

>PPIN_calMil Callorhinchus milii (elephantfish) Deut.Chon.Holo genomic frag Gt parapinopsin
0 MDPHNRSANLSEGPGLGGGGAVPGWGPSVRAPLSLVMAVISLSSIVLNSLAIAVVLRFQVLQQPLNYALLSLASADLGTAATGGVLSTVCTALGSFVLGRHSCVAEGFF 1

>PPINa_petMar Petromyzon marinus (lamprey) Deut.Agna.Hype genomic full Gt parapinopsin bistable pineal UV/green
0 MENLTSLDLLPNGEVPLMPRYGFTILAVIMAVFTLASLVLNSTVIIVTLRHRQLRHPLNFSLVNLAVADLGVTVFGASLVVETNAVGYFNLGRVGCVIEGFAVAFF 1
2 GIAALCTIAVIAVDRFVVVCKPLGTLMFTRRHALLGITWAWLWSFVWNTPPLFGWGSYKLEGVRTSCAPDWYSRDPANVSYIVSFFSFCFAIPFLVIVVAYGRLLWTLHQ 0
0 VAKLGMGESGSTAKAEAQVSRMVVVMVVAFLVCWLPYALFAMIVVAKPGVYIDPVIATLPMYLTKTSTVYNPIIYIFMNRQ 0
0 FRDCAVPFLLCGRNPWAEPSSESATTASTSATSVTLASVPGQVSPS* 0

>PPINb_petMar Petromyzon marinus (lamprey) Deut.Agna.Hype genomic frag G? parapinopsin odd genomic
2 GMTALITVCVLAVERYVVVCKPLGGVHFGTQHGLCGVAISWTWALAWSAPPLFGWGRYHYEGVGTSCAPDWADSSPSGRSYMTTYFIFCFALPMIIILFCYTKLMIAIHK 0
0 VSKLGLSANDTAERKVGIMVVVMVFAFFLCWLPYAALAIAVVIKPDLK 0
0 VSPVTASIPVYLAKSSGAYNPIIYIFMHRQ 0

>PPIN_letJap Lethenteron japonicum (lamprey) Deut.Agna.Hype AB116380 14981504 full Gt parapinopsin bistable pineal UV/green
0 MENLTSLDLLPNGEVPLMPRYGFTILAVIMAVFTIASLVLNSTVVIVTLRHRQLRHPLNFSLVNLAVADLGVTVFGASLVVETNAVGYFNLGRVGCVIEGFAVAFF 1
2 GIAALCTIAVIAVDRFVVVCKPLGTLMFTRRHALLGIAWAWLWSFVWNTPPLFGWGSYELEGVRTSCAPDWYSRDPANVSYITSYFAFCFAIPFLVIVVAYGRLMWTLHQ 0
0 VAKLGMGESGSTAKAEAQVSRMVVVMVVAFLVCWLPYALFAMIVVTKPDVYIDPVIATLPMYLTKTSTVYNPIIYIFMNRQ 0
0 FRDCAVPFLLCGRNPWAEPSSESATAASTSATSVTLASAPGQVSPS* 0

>PPINa_cioInt Ciona intestinalis (tunicate) Deut.Uroc.Tuni NM_001032555 11591373 full Gt Ci-opsin1 syn(-HOXB1 +HHEX +CUL4A -) odd exons larval ocellus
0 MDHDVTPTVDLTDGVPQCKDLNPYVLKGDGWVPQHISRANRSTYSFLCVYMTFVFLLSCSLNILVIVATLKNK 0
0 VLRQPLNYIIVNLAVVDLLSGFVGGFISIAANGAGYFFWGKTMCQIEGYFVSNF 1
2 GVTGLLSIAVMAFERYFVICKPFGPVRFEEKHSIF 1
2 GIVITWVWSMFWNTPPLIFWDGYDTEGLGTSCAPNWFVKEKRERLFIILYFVFCFVIPLAVIMICYGKLILTLRQ 0
0 IAKESSLSGGTSPEGEVTKMVVVMVTAFVFCWLPYAAFAMYNVVNPEAQ 0
0 IDYALGAAPAFFAKTATIYNPLIYIGLNRQ 0
0 FRDCVVRMIFNGRNPWVDELVGSQVSSTGSQLTAVSSNKVAPA* 0

>PPINb_cioInt Ciona intestinalis (tunicate) Deut.Uroc.Tuni genomic full Gt parapinopsin syn(-TMEM165 +FUT4 - -) jgi gene model wrong both ends
0 MTTAETTTECYEKNPYIRNEMGWVPKHILIAERHIYTILAVYMTFIFLLAVSLNGFVIIATMKNK 0
0 KLRQPLNYIIINLSIADFLSGLVGGFIGMISNSAGYFYFGKTVCILEGYIVSVA 1
2 GVCGLMSISVMAFERYFVVCKPYGPFTLTNTHAAL 1
2 GIGFTWTWSVLWSTPGLIWLDGYVPEGLGTSCAPNWFSKNK 2
1 SERIFIFVYFVFCFFIPLLVIIICYGKIVLFLKQ 0
0 ATRQSSASSNRQADNKVTKMVLVMISAFLICWTPYGVLSLYNAINPDKQ 0
0 LDYGLGAVPVFFAKTANIYNPLIYIGLNKQ 0
0 FRDGVIKMVFRGRNPWAEEMSTQQRQRSTEAGQPIVSNEV* 0

>PPINa_cioSav Ciona savignyi (tunicate) Deut.Uroc.Tuni genomic full G? parapinopsin
0 MPTEASIAVDVSPTMGIPQCKDINPYVLKGDGWVPQHISRADRSVYSFLAVYMTFICLISCSLNILVITATLKNK 0
0 VLRQPLNYIIVNLAVVDLLSGLVGGVISIFANGAGYFFWGKFMCQVEGYTVSNF 1
2 GVTGLLSIAVMAFERYFVICKPFGPVRFEEKHAVI 1
2 GIAVTWIWAMFWNTPPLIFWDGYDTEGLGTSCAPNWFVKGNTERLFIILYFVFCFLIPLAIIVLCYGKLILQLRQ 0
0 IAKESSLSGGTSPEGEVTKMVVVMVTAFVICWLPYAAFAMYNVVNPEAQ 0
0 IDYALGAAPAFFAKTATIYNPLIYIGLNRQ 0
0 FRDCVVRMIFNGRNPWVDEMVGSQVSSSASQMTAVSSNKVAPA* 0

>PPINb_cioSav Ciona savignyi (tunicate) Deut.Uroc.Tuni genomic full G? parietopsin
0 MSSIPQNYSNGNPYATTDSGWVPEHIEIANRSTYSGLCVFMSFVFVLAVPLNLLVIVATYKNK 0
0 DLRRPINYIIVNLAVADLTCSVVGGLLGVLNNGAGYYFLGKSVCIFEGYVMSVT 1
2 GVCGILSITVMAFERYFVVCKPFGQTNLKWSHAIT 1
2 GIVFTWTWSVIWHTPGLFFWNGYEPEGFGTSCAPNWFSQQK 2
1 SERIFIFAYFAFCFLTPLTIIFACYLKLILFIRK 0
0 VSKKSMVNEADRRDFEVTRMVFVMIAAFLICWLPYGCLSMYNAIHPDNL 0
0 LSYGIGSVPAFFAKTATIYNPIIYMGLNKK 0
0 FRDGVIRMLFKGRNPWLDGRNTTSSTSTRAQGSLINREVDI* 0

>PARIE_anoCar Anolis carolinensis (lizard) Deut.Saur.Lepi genomic full Gd+Go parietopsin syn(+EEA1 -FLJ46688 +BTG1 -) gusducin not transducin
0 MENESSLVLEGAEGYIVRPTIFPRAGYGVLAFLMFINALFSLFNNFLVIAVTLKNPQLRNPINIFILNLSFSDLMMSICGTTIVIATNYHGYFYLGRRFCIFQGFAVNYF 1
2 GIVSLWSLTILAYERYNVVCQPLGTLQMSTQRAYQLLGFIWVFCLFWAVVPLFGWSSYGPEGVQTSCSIGWEERSWNNYSYLIVYFLSCFFIPVLIIGFSYGNVIRSLHG 0
0 LNKKVEQLGGKSNPEEEFRAVIMVLVMVVAFLICWLPYTLFALTVVFNPALNISPLAATIPTYLSKTSPVYNPIIYIFLNKE 0
0 FRECAVEFITCGKVVLTSPEEDISTSAISDEGIAPCKINQVTPV* 0

>PARIE_utaSta Uta stansburiana (lizard) Deut.Saur.Lepi DQ100320 16543463 full Gd+Go parietopsin shift in counterion
0 MENDSSLATELAEGAIVKPTIFPKAGYGVLAFLMFLNALFSIFNNSLVIAVTLKNPQLRNPINIFILNLSFSDLMMSLCGTTIVIATNYYGYFYLGRKFCIFQGFAVNYF 1
2 GIVSLWSLTILAYERYNVVCQPLGTLQMSTKRGYQLLGFIWVFCLFWAVVPLFGWSSYGPEGVQTSCSIGWEERSWSNYSYLIVYFLSCFFIPVLIIGFSYGNVIRSLHG 0
0 LNKKVEQLGGKSSPEEEFRAVIMVLVMVVAFLICWLPYTVFALIVVFNPALNISPLAATIPTYLSKTSPVYNPIIYIFLNKQ 0
0 FRDCAVEFITCGQVVLTSPEEDISTSAIPVEGKGPCKINQVTPV* 0

>PARIE_xenTro Xenopus tropicalis (frog) Deut.Amph.Anur DN070761 16543463 full Gd+Go parietopsin syn(-lum -DCN) lung
0 MDGNSTTPGIAVNLTVMPTIFPRSGYSILSFLMFLNAVFSICNNAIVILVTLKHPQLRNPINIFILNLSFSDLMMALCGTTIVVSTNYHGYFYLGKQFCIFQGFAVNYF 1
2 GIVSLWSLTLLAYERYNVVCEPIGALKLSTKRGYQGLVFIWLFCLFWAIAPLFGWSSYGPEGVQTSCSIGWEERSWSNYSYIISYFLTCFIIPVGIIGFSYGSILRSLHQ 0
0 LNRKIEQQGGKTNPREEKRVVIMVLFMVLAFLICWLPYTVFALIVVINPQLYISPLAATLPTYFAKTSPVYNPIIYIFLNKQ 0
0 FRTYAVQCLTCGHINLDSLEEDTESVSAQAENMLTPKTNQVAPA* 0

>PARIE_danRer Danio rerio (zebrafish) Deut.Acti.Otoc genomic 16543463 full Gd+Go parietopsin syn(- +NT5DC2 +FBXL13)
0 MENFAKTELTMMVQPTIFPRVGYSILSYLMFINTTLSVFNNVLVIAVMVKNLHFLNAMTVIIFSLAVSDLLIATCGSAIVTVTNYEGSFFLGDAFCVFQGFAVNYF 1
2 GLVSLCTLTLLAYERYNVVCKPMAGFKLNVGRSCQGLLLVWLYCLFWAVAPLLGWSSYGPEGVQTSCSLGWEERSWRNYSYLILYTLMCFILPTVIITYCYSNVLLTMRK 0
0 INKSIECQGGKNCAEDNEHAVRMVLAMIIAFFICWLPYTAISVLVVVNPEISIPPLIATMPMYFAKTSPVYNPIIYFLTNKR 0
0 FRESSLEVLSCGRYISRETGGPLMGSSMQRGQSRVNPV* 0

>PARIE_tetNig Tetraodon nigroviridis (pufferfish) Deut.Acti.Perc genomic full G? parietopsin genomic frameshift error
0 MDSASTPWSPHPASGQAEAVTAAPTIFPRVGYSILSFLMFINTVLSIFNNGLAITVMLKNPALLQPINIFILSLAVSDLMIGLCGSLVVTITNYQGSFFIGHTACVFQGFAVNYF 1
2 GLVSLCTLTLLAYERYNVVCKPRAGLKLNMRRSLVGLLFVWTFCLFWAVTPLLGWSSYGPEGVQTSCSLAWEERSWNNYSYLILYTLLCFILPVGVIIYCYTKVLTSMNK 0
0 LNKSVELQGGRSCQKENDHAISMVLAMIIAFFVCWLPYTALSVVVVVDPELRIPPLVATMPMYFAKTSPVYNPIIYFLSNKQ 0
0 FRDATLEVLSCGRYIPHASTRVTFNMCAFNRRSRLPSLSRSINTHSKVSPL* 0

>PARIE_takRub Takifugu rubripes (fugu) Deut.Acti.Perc genomic 16543463 full Gd+Go parietopsin syn(-HSP90B1 +NT5DC2 -KCND3 -FLNC)
0 MDSNSTPWSSPPAPLQAEAVTVAPTIFPRVGYSILSFLMFINTVLSVFNNSLAIAVMLKNPSLLQPINIFILSLAVSDLMIGLCGSLVVTITNYHGSFFIGHTACVFQGFAVNYF 1
2 GLVSLCTLTLLAYERYNVVCKPRAGLKLTMRRSIIGLLFVWTFCLFWAVTPLLGWSSYGPEGVQTSCSLAWEERSWNNYSYLILYTLLCFIFPVGVIIYCYCKVLTSMNK 0
0 LNKSVELQGGLSCRRENKHAINMVLAMIIAFFVCWLPYTALSVVVVVDPELHIPPLVATMPMYFAKTSPVYNPIIYFLSNKQ 0
0 FRDATLEVLSCSRYIPHASSRVSINMRSLNRRSVNTHSKVSPL* 0

>PARIE_gasAcu Gasterosteus aculeatus (stickleback) Deut.Acti.Perc genomic full G? parietopsin syn(-HSP90B1 +NT5DC2 -KCND3 -FLNC)
0 MDSNSTLWSSGSPPPSIHGKMLTITPTIFPRVGYSILSFLMFINTVLTVFNNVLVITVLVRNPSLLQPMNVFILSLAVSDLMIGLCGSLVVTITNYHGSFFIGHTACIFQGFAVNYF 1
2 GLVSLCTLTLLSYERYNVVCRPRNALKLSMRRSIHGLLIVWTFCLFWAVAPLFGWSGYGPEGVQTSCSLAWEERSWSNYSYLVLYTLLCFIVPVAVIIYCYAKVLTSMNT 0
0 LNRSVEVQGGRSSQKENDHAVSMVLAMIIAFFSCWLPYTALSVVVVVDPTLYIPPLVATMPMYFAKTSPVYNPIIYFLSNKQ 0
0 FRDAALEMLSCGRYIAHMPNTVSINMRSLNRRSRLSSLSRNVNSHSKVLPL* 0

>PARIE_petMar Petromyzon marinus (lamprey) Deut.Agna.Hype genomic frag Gd+Go parietopsin
0 LNKKIKRVGGHPDPREEMRATVMVLAMVGAFLACWLPYTVLALCVVLAPGTQIPPLVATLPMYFAKTSPIYNPIIYFFLNRQ 0

>ENC_homSap Homo sapiens (human) Deut.Euth.Euar NM_014322 12242008 full Gt OPN3 encephalopsin syn(-EXO1 -WDR64 -KMO +FH) with intron loss
0 MYSGNRSGGHGYWDGGGAAGAEGPAPAGTLSPAPLFSPGTYERLALLLGSIGLLGVGNNLLVLVLYYKFQRLRTPTHLLLVNISLSDLLVSLFGVTFTFVSCLRNGWVWDTVGCVWDGFSGSLF 1
2 GIVSIATLTVLAYERYIRVVHARVINFSWAWRAITYIWLYSLAWAGAPLLGWNRYILDVHGLGCTVDWKSKDANDSSFVLFLFLGCLVVPLGVIAHCYGHILYSIRM 0
0 LRCVEDLQTIQVIKILKYEKKLAKMCFLMIFTFLVCWMPYIVICFLVVNGHGHLVTPTISIVSYLFAKSNTVYNPVIYVFMIRK 0
0 FRRSLLQLLCLRLLRCQRPAKDLPAAGSEMQIRPIVMSQKDGDRPKKKVTFNSSSIIFIITSDESLSVDDSDKTNGSKVDVIQVRPL* 0

>ENC_otoGar Otolemur garnettii (lemur) Deut.Euth.Euar genomic full G? OPN3 encephalopsin
0 MYSGNRSGGQGFWEGGGAAGAEEPTPEGTLSPAPLFSPSAYERLALLLGSIGLLGVANNLLVLVLYYKFPRLRTPTHLFLVNISLSDLLVSLFGVTFTFVSCLRNGWVWDTVGCVWDGFSGSLF 1
2 GIVSIATLTVLAYERYIRVVHARVINFSWAWRAITYIWLYSLAWAGAPLLGWNRYILDVHGLGCTVDWKSKDANDSSFVLFLFLGCLVVPVGVVAHCYGHILYSIRM 0
0 LRCVEDLQTTQVIKILKYEKKVAKMCFFMIFTFLVCWMPLIVICFLVVNGQGHLVTPTVSIVSYLLAKSNTVYNPVIYIFMLRK 0
0 FRRSLLQLLCFRLLRCQRPAKDLPAAESEMQIRPIVMSQKDGDRPKKKVTFNSSSIIFIITSDESLSVDNSDKTNGSKVDVIQVRPL* 0

>ENC_musMus Mus musculus (mouse) Deut.Euth.Euar NM_010098 full G? OPN3 encephalopsin panopsin 2aa del
0 MYSGNRSGDQGYWEDGAGAEGAAPAGTRSPAPLFSPTAYERLALLLGCLALLGVGGNLLVLLLYSKFPRLRTPTHLFLVNLSLGDLLVSLFGVTFTFASCLRNGWVWDAVGCAWDGFSGSLF 1
2 GFVSITTLTVLAYERYIRVVHARVINFSWAWRAITYIWLYSLAWAGAPLLGWNRYILDIHGLGCTVDWRSKDANDSSFVLFLFLGCLVVPVGIIAHCYGHILYSVRM 0
0 LRCVEDLQTIQVIKMLRYEKKVAKMCFLMAFVFLTCWMPYIVTRFLVVNGYGHLVTPTVSIVSYLFAKSSTVYNPVIYIFMNRK 0
0 FRRSLLQLLCFRLLRCQRPAKNLPAAESEMHIRPIVMSQKDGDRPKKKVTFNSSSIIFIITSDESLSVEDSDRSSASKVDVIQVRPL* 0

>ENC_canFam Canis familiaris (dog) Deut.Euth.Laur DN422921 full early gap G? OPN3 encephalopsin XP_854433 grossly wrong
0 MYSGNRSGGQGHWEGGGAAGAEGPGPAGTLSPAPLFSPGTYERLALLLGSVGLLGVGNNLLVLVLYSKFQRLRTPTHLLLVNLSLSDLLVSLFGVTFTFVSCLRNGWVWDSVGCVWDGFSSSLF 1
2 GIVSITTLTVLAYERYIRVVHARVINFSWAWRAITYIWLYSLAWSGAPLLGWNRYILDVHGLGCTVDWKSKDANDSFFVLFLFLGCLVVPMGVIVHCYGHILYSIRM 0
0 LRCVEDLQTIQVIKILRYEKKVAKMCFLMIFIFLIFWMPYIVICFLVVNGYGHLVTPTVSIVSYLFAKSSTVYNPVIYIIMIRK 0
0 FRRSLLQLLCFRPLRCQRPAKDLPANGSEMQIRPIVMSQKDGDRPKKKVTFNSSSIIFIITSDESVSIDDSDKTSVSKVDVIQVRPL* 0

>ENC_pteVam Pteropus vampyrus (macrobat) Deut.Euth.Laur genomic full G? OPN3 encephalopsin
0 MHSGNRSGGLDSWEGGGAAGAEGPGLAGTLSPGSVFNPSTYERLALLLGSIGLLGVANNLLVLVFYYKFQQVRTPFYLFLVNISFSDLLVSFFGVTFTFVSCLRNGWVWDTVGCVWDGFSSSLF 1
2 GTVSMTTLTVLAYERYIRVVQARAIDFSWAWRTITYIWLYSLGWSGAPLLGWNRYILDVHGLGCAVDWKSKDANDSSFVLFLFLGCLVVPVVVIAHCYGHILYSVQM 0
0 LRCVEDLQTIQVIKILRYEKKMAKMCFLMIFTFLISWMPYIVICFLVVNGYGHLVTPTVSIVSYLFAKSSTVYNPVIYIFMIRK 0
0 FRRFVLQLLCFRPLRCRRPATDLPAGGSEMQIRPIVMSQKDGDRPKKKVTFNSSSIIFVITSDESLSVDDSDKINGSKADGIQVRPL* 0

>ENC_loxAfr Loxodonta africana (elephant) Deut.Euth.Afro genomic full G? OPN3 encephalopsin 2 exons in browser 1 2x
0 MYSGNRSGGQDLWEGGGGSGGAGPAGTLSPAPVFRSGTYERLALLVGSIGLLGVGNNLLVLVLYYKFQRLRTPTHLFLVNISLSDLLVSLFGVTFTFVSCLRNGWVWDTVGCVWDGFSSSLF 1
2 GIASITTLTVLAYERYIRVVHARVINFSWAWRAITYIWLYSLAWSGAPLLGWNRYILDTHGLACTVDWKSNNSSDSSFVLFLFLGCLVVPVGVIAHCYGHILYSIRM 0
0 LRCVEDLQTIQVIKILRHEKKLAKMCLFMIFTFLICWMPYIVICFLVVNGYGHLVTPTISIVSYLFAKSSTVYNPVIYTFMIRK 0
0 FRRSLLQLLCFRLLRCQRPAKDLPVVGSEMQIRPIVMSQKDGDRPKKKVTFNSSSIIFIITSDESLSVNNIDKTNGSKADVIQIRPL* 0

>ENC_monDom Monodelphis domestica (opossum) Deut.Meta.Dide genomic full G? OPN3 encephalopsin syn(-EXO1 -WDR64 +ENC -KMO +FH +RGS7)
0 MYSDNSSDDGGGGYWGSGRAGGASGTGVTGEPGPEGSPRQAPLFSPGTYELLALLIATIGLLGLCNNLLVLVLYYKFQRLRTPTHLFLVNISFNDLLVSLFGVTFTFVSCLRSGWVWDSVGCAWDGFSNTLF 1
2 GIVSIMTLTVLAYERYNRIVHAKVINFSWAWRAITYIWLYSLVWTGAPLLGWNRYTLEIHGLGCSVDWKSKDPNDSSFVIFLFFGCLMLPVGVMAYCYGHILYAIRM 0
0 LRCVEELQTIQVIKILRYEKKVAKMCFLMIAIFLFCWMPYAVICLLVANGYGSLVTPTVAIIASLFAKSSTAYNPIIYIFMSRK 0
0 FRRCLLQLLCFRLLKFQQPKKDRPVIRTEKQIRPIVMSQKVGDRPKKKVTFSSSSIIFIITSDETQMIDENDKNSGTKVNVIQVRPL* 0

>ENC_galGal Gallus gallus (chicken) Deut.Saur.Arch genomic full Gt OPN3 encephalopsin syn(-EXO1 -WDR64 +ENC -PIGM +R
0 MHSGNGTGATSRPQLAAAGHEVPGERPLFSAGTYELLALLIATIGTLGVCNNLLVLVLYYKFKRLRTPTNLFLVNISLSDLLVSVCGVSLTFMSCLRSRWVWDAAGCVWDGFSNSLF 1
2 GIVSIMTLTVLAYERYIRVVHAKVIDFSWSWRAITYIWLYSLAWTGAPLLGWNRYTLEIHGLGCSMDWKSKDPNDTSFVLLFFLGCLVAPVVIMAYCYGHILYAVRM 0
0 LRCVEDFQTSQVIKLLKYEKKVAKMCFLMISTFLICWMPYAVVSLLVTYGYSNLVTPTVAIIPSFFAKSSTAYNPVIYIFMSRK 0
0 FRQCLLQLLCFRLMRFQRIMKEPSGAGNVKPIRPIVMSQKVGDRPKKKVTFSSSSIIFIIASDDTQQIDDNSKHNGTKVNVIQVKPL* 0

>ENC_anoCar Anolis carolinensis (lizard) Deut.Saur.Lepi genomic full Gt OPN3 encephalopsin syn(-EXO1 -WDR64 +ENC -PIGM +RGS7)
0 MFSANGTRSGAGSDLEPGPGQQQQQREASEEEERGAGLSPFSAGTYELLALLVAAIGLLGLCNNLLVLVLYAKFKRLRTPTHLFLVNISLSDLLVSLFGVSFTFGSCLRHRWVWDAAGCVWDGFSNSLF 1
2 GIVSIMTLTVLAYERYIRVVHARVIDFSWSWRAITYIWLYSLAWTGAPLLGWNHYTLEIHGLGCSVDWQSKEPSDSSFVLFFFLGCLAAPVGIMAYCYGHILHAIRM 0
0 LRCVEDLQSIQVIKILRYEKKVAKMCFLMVTTFLICWMPYAVVSLLIAYGYGHLITPTVAIIPSFFAKSSTAYNPVIYIFMSRK 0
0 FRRCLVQLFCVQFLRFKRTLKEQPAIESNKPIRPIVMSQKVGDRPKKKVTFSSSSIIFIITSDDTEQIDVSTKCSDTKINVIQVKPL* 0

>ENC_xenTro Xenopus tropicalis (frog) Deut.Amph.Anur genomic pseu G? OPN3 encephalopsin recent pseudogene I for Schiff K C-term residues lost
0 MPVTNGSHNNSISWLHSKDMFTEDTYHFLALIVATVGFLGLVNNLLVLILYCKFKRLQTPTNLLFFNTSLCHFVFSLLAITFTFMSCVRGSWAFSVEMCVFHGFSKNLL 1
2 GIVSFGTLTVVAYERYARVVYGKYVNSSWSKRSITFVWVYSLAWTGFPLIGWNLYTFETHKLDCSFEWTATDPKDTAFVLLFFLACITLPLSIMAYCYGYILYEIQK 0
0 LRSVKNIQNFQEITILDYEIKMAKMCLLMMLTFLIGWMPYTILSLLVTSGYSKFITPTITVMPSLLAIASAAYNPVIHIFTIKK 0
0 FRQCLVQLLFHNFWRLLKNLNGRLAMKKVKPVLGKGRSHNRPEKKVFSSSDFFTRTTSDTGTHGITESTKGKRTNVRLIQVHPLYP* 0

>ENC_danRer Danio rerio (zebrafish) Deut.Acti.Otoc NM_001111164 full G? OPN3 encephalopsin
0 MNSFNETPTEAHLENYNYIFADETYKLLTFTIGSIGVLGFCNNIIVIILYSRYKRLRTPTNLLIVNISVSDLLVSLTGVNFTFVSCVKRRWVFNSATCVWDGFSNSLF 1
2 GIVSIMTLSGLAYERYIRVVHAKVVDFPWAWRAITHIWLYSLAWTGAPLLGWNRYTLEVHQLGCSLDWASKDPNDASFILFFLLGCFFVPVGVMVYCYGNILYTVKM 0
0 LRSIQDLQTVQTIKILRYEKKVAVMFLMMISCFLVCWTPYAVVSMLEAFGKKSVVSPTVAIIPSLFAKSSTAYNPVIYAFMSRK 0
0 FRRCMLQMLCSRLTSLQHTIKDRPLSRIEHPIRPIVMSQSRTDRPKKRVTFSSSSIVFIIASHDTHPLDITSKCNDEPDINVIQVRPL* 0

>ENC_tetNig Tetraodon nigroviridis (pufferfish) Deut.Acti.Perc genomic full G? OPN3 encephalopsin
0 MSSADDSRSARSGEPSLFAVHTYRLLAAAIGAIGVLGFCNNLAVAALYWRFRRLRTPTNLLLLNISLSDLLVSLLGVNFTFAACVQGRWTWNQATCVWDGFSNSLF 1
2 GIVSIMTLAALAYERYIRVVHAQVVDFPWAWRAIGHIWLYSLAWTGAPLLGWNRYTLEIHRLGCSLDWASKDPNDASFILLFLLACFFVPVGIMIYCYGNILYAVHM 0
0 IRSIQDLQTVQIIKILRYEKKVSVMFFLMISCFLLCWTPYAVVSMMVAFGRKSMVSPTVAIIPSFFAKSSTAYNPVIYVFMSRK 0
0 FRRCLLQLLCSRLSWLQRGLKERPLAPVQRPIRPIVVSRPCGKGTRPKKKVTFSSSSIVFIITSDDFRQLDVTSRAGDSADVNAIQVRPL* 0

>ENC_takRub Takifugu rubripes (fugu) Deut.Acti.Perc genomic full G? OPN3 encephalopsin
0 MNPANGSRSERSAEQLLFSGDTYRVLAFTIGTIGAFGFCNNFVVLALYCRFKRLRTPTNLLLVNISLSDLLVSLFGINFTFAACVQGRWTWTQATCVWDGFSNSLF 1
2 GIVSIMTLAALAYERYIRVVHAQVVDFPWAWRAIGHIWLYALAWTGAPLLGWNRYTLEIHRLGCSLDWASKDPNDASFILLFLLACFFVPVGIMIYCYGNILYAVQM 0
0 IRSIQDLQTVQIIKILRYEKKVSVMFFLMISCFLLCWTPYAVVSMMVAFGRRSMVSPTMAIIPSFFAKSSTAYNPLIYVFMSRK 0
0 FRHCLLQLLCSRLSWLQRSLKERPLAPVQRPIRPIVMSRPCGKGNRPKKKVTFSSSSIVFIITSDDFGQLDVTSKSGDSADVNAIQVRPL* 0

>ENC_gasAcu Gasterosteus aculeatus (stickleback) Deut.Acti.Perc genomic full G? OPN3 encephalopsin
0 MNPDNGTREERSTDHSIFAVGTYKLLAFAIGTIGVFGFCNNVVVIVLYCKFKRLRTPTNLLVVNISLSDLLVSVIGINFTFVSCIRGGWTWSRATCIWDGFSNSLF 1
2 GIVSIMTLASLAYERYIRVVHAQVVDFPWAWRAIGHIWLYSLVWTGAPLLGWNRYTLEIHRLGCSLDWASKDPNDASFILLFLLACFFVPVGIMIYCYGNILYAVQM 0
0 LRSIQDLQTVQIIKILRYEKKVAVMFLLMISCFLLCWTPYAVVSMMEAFGRKNMVSPTVAIIPSFFAKSSTAYNPLICVFMSRK 0
0 FRRCLMQLLCSRVTCLQCNLKERPLAPVQRPIRPIVVSAACGGGRVRPKKRVTFSSSSIVFIITRNDIRHTDVTSNTRESSEANVFQVRPL* 0

>ENC_oryLat Oryzias latipes (medaka) Deut.Acti.Perc genomic full G? OPN3 encephalopsin
0 MNPANESRAGRHEERSVFAVGTYKLLTVIIGTIGVFGFCNNLLVILLYCKFKRLRTPTSLLLVNISLSDLLVSVVGINFTLASCVKGRWMWSQATCVWDGFSNSLF 1
2 GIVSIMTLAALAYERYIRVVHAQVVDFPWAWRAIGHIWLYSLAWTGAPLLGWNRYTLEIHQLGCSLDWASKDPNDAAFILLFLLGCFFVPVGIMIYCYGNILYAVRM 0
0 LRSIEDLQTVQIIKILRYEKKVAAMFLLMISCFLVCWTPYAVVSMMEAFGKKSMVSPTVAIVPSFFAKSSTAYNPLIYVFMNRK 0
0 FRRCFLQLLGSRLCSKISWLQCTLKEHPLTPVERPIRPIVASTSCGSRHRPKKRVTFNSSSIVFMITGDEFQQLDVTSKSRNSSEANVFHVRPL* 0

>ENC_calMil Callorhinchus milii (elephantfish) Deut.Chon.Holo genomic frag G? OPN3 encephalopsin
0 MNPTNSTEPQEEHLFSPNTYKLLAVIIGTIGIVGFCNNILVLLLYYKFKRLRTPTNLLLVNISVSDLLVSVFGLSFTFVSCTQGRWGWDSAACVWDGfSHSLF 1
2 GTVSIVTLTVLAYERYIRVVNAKATNFPWAWRAITYTWFYSLAWSGAPLV
0 yRRCLSQLFCSHLMSLQWSIKDPSSKARNDMPVKPIVLSQKGDRPKKRVTFSSSSIVFIITSDDTQELGSIAGSNATQISIVQVQPL* 0

>ENC_squAca Squalus acanthias (dogfish) EB687868 frag Gt OPN3 encephalopsin
0 MNAANSTDTREESLFSPGTYQVLAVIIGTIGVVGFCNNLLMLVLYCKFKRLRTPTNLFLVNISISDLLLSVFGVIFTFVSCVKGRWVWDSAACVWDGFSNCLF 1
2 GISSIMSLTVLAYERYIRVVNATAIDFSWAWRAITYIWLYSLAWTGAPLIGWNSYTLELHRLGCSVNWDSRNPSDTSFVLFLFLGCLLCPIGVIAYCYG

>ENC_leuEri Leucoraja erinacea (skate) Deut.Chon.Elas FL592692 frag
0 MNTANSTEIPAETLFGAGAYKVLAVVVGTVGAVGFCNNLLMLVLYCKFKRLRSPANLFLVNISISDLLLSVFGIFFTLVSCVKGGWVWDNSACIWDGFSNTLF 1
2 GISSIMSLTVLAYERYLRMVNATAINFTWAWRAVTYIWLYSLAW

>ENC_torCal Torpedo californica (ray) Deut.Chon.Elas EW690209 17309107 frag electric organ
2  WSGAPLLgwNRYTLEMHRLGCSVTwELEKPSDTSFILFLFLGSLLLIPVGVIAYCYGNIFYTIRM 0
0 LQSIEDFQTARFAKTLTNEMNSSKMCFFMISVAFSCWLPYAVTSFMVVYGCTDVITPTITIIFSLLAKSSAISYPIIYIFMSRK 0
0 FRWCLMQLLCFRLVRIKWAIKDRTVRIRSDKPIKPIVIFEKVVNRPKKRVTFSSFSIIFIANDETQDIGSTAELNATNQNVVQVRPLRSERAER* 0

>ENC_petMar Petromyzon marinus (lamprey) Deut.Agna.Hype genomic full Gt OPN3 encephalopsin rough sequence in two contigs
0 MQSPKQDSLHYAGDTGAKAAPDSAQGNASALGSNFLLHGGDLGEGSTAFSAATFRLLAGVVGTIGVAGFLNNLLLVALFVGFKRLQTPTNLLLVNISLSDLLVSVFGNTLTLVSCVRRRWVWGNGGCVWDGFSNSLF 1
2 GIVSISTLTALSYERYARLIKAQVLDFSWAWRAVTYTWLYSAAWTGAPLLGWSRYVLEKHGLGCSIDWASSNPPDAAFVLFFFLGCLAAPLLVMGFCFGRIALAITQ 0
0 FRKLDRLQTPRVLKARCSERKVSAVCLLMMLLFLLCWSPYAVASLFVASGFEHLVSPPVSIVPSLLAKSNAVCNPLLFLLMSGN 0
0 FFRCLRTMFFTLRWRVNLSRVGIVCPQSQRRPRQREAARPKKKATFNSSSIVFIISSSEEDPVEPADAEGEKSDALAAPADTCVVHVKPT* 0

>ENC4_braFlo Branchiostoma floridae (amphioxus) Deut.Ceph.Bran AB050608 12435605 full Gt Amphiop4 syn(-ZFYVE1 +RTF1 -CES1 -POMT2) new exon 12 and 34
0 MALYNNTSSPSQDLLWDAPYSQGHIWDNSSASNSSEDVMDQGKVELQDFSDAGYTAIATCLALI 1
2 GFVGFTNNFVVILLIGCHRQLRTPFNLLLLNMSVADLLVSVCGNTLSFASAVRHRWLWGRPGCVWYGFANSLF 1
2 GIVSLVTLSALAFERYCVVVRSSDMLTYKSSLVVITFIWLYSLLWTSLPLLGWSSYQFEGHN 0
0 VGCSVNWVQHNPDNVSYIVTLMVTCFFVPMVVVCWSYAWIWRTVRM 0
0 SSEAKPECGNSQNAGRLVTTMVVVMIICFLVCWTPYAVMALIVTFGADHLVTPTASVIPSLVAKSSTAYNPIIYVLMNNQ 0
0 FREFLLARLQRVCCRQQAVPRVTPMDDNVHVRLGGEGPSQSQQFLPAGENVENVDMLEYVQENCKPKADSLSTISE* 0

>ENC4_braBel Branchiostoma belcheri (amphioxus) Deut.Ceph.Bran AB050608 12435605 full G? Amphiop4 introns from braFlo
0 MPLYNTSSGPTQGLPWDTPYSQDPIWNDSSPSNSSEDAVVDQGRGELQDFSDAGYTAIATGLALI 1
2 GLVGSMNNFVVILLIGCHRQLRTPFNLLLLNVSVADLLVSVCGNTLSFASAVQHRWLWGRPGCVWYGFANSLF 1
2 GIVSLVTLSALAFERYCVVVRSSEMLTYKSSLGMIAFIWMYSLLWTSLPLLGWSSYQFEGHS 0
0 VGCSVNWVKHNVNNVSYIITLMVTCFFVPMVVVCWSYACIWRTVRM 0
0 SAEMKSEFGNPQNTGRLVTTMVVVMIVCFLVCWTPYTVMALIVTFGADHLVTPTASVIPSLVAKSSTAYNPIIYVLMNNQ 0
0 FREFLLARLRTFCCRQPRMLRVTPMDDNAHARLVGEGPSHAQQVIPSEENGENVEMRKVQGNQLKADSLSTISE* 0

>ENC_strPur Strongylocentrotus purpuratus (sea_urchin) Deut.Echi.Eleu AAGJ02133080 full G? OPN3 encephalopsin terminal exon extended to stop codon
0 MENFTSIVTDGTNEENTDGDAWPGYAHLLAGSFLTLVFIISIIGNSVVLFLFAWDRHLRTPTNMFLLSLTISDWLVTVVGIPFVTASIYAHRWLFAHVGCIS 2
1 YAFIMTFLGLNSLMSHAVIAVDRYLVITKPHF 1
2 GIVVTYPKAFLMISIPWVFSFAWAVFPLAGWGEFTYEGTGAWCSVRWDSDQPQIMSYVLAMMFLTFISSIVIMMYCYICIFLTTRRMPRWATSNSIKTHERNRRRR 2
1 EQKLLKTLIAIAIAFLVAWSPYAITSMIVVFGGSELLSLTATTLPSLFAKSSVMINPIIYAVTSRVFRKSLKK 0
0 MLTSFFPGCMTYIMTDKSPPSSSRPIQLGLCKYHFLY* 0

>TMT5_braFlo Branchiostoma floridae (amphioxus) Deut.Ceph.Bran XM_002589165 12435605 full G? Amphiop5 extra 0 intron
0 MLGMHNVMNATDYDNNNATFAAWNFQRNGTTEEEVEFSGFDTVAVVIAAIGIAGFLSNGAVVLLFLKFRQLRTPFNMLLLNMSVADLLVSVCGNTLSFASAVRHRWLWGRPGCVWYGFANHLF 1
2 GLVSLISLAVISYERYRMVVKPKGPGSSYLTYNKVGLAIIFIYLYCLLWTTLPIVGWSSYQLE 0
0 GPKISCSVAWEEHSLSNTSYIVAIFIMCLLLPLLIIIYSYCRLWYKVKK 0
0 GSQNLPPAIRKSSQKEQKIARMVVVMITCFLVCWLPYGAMALVVSFGGESLISPTAAVVPSLLAKSSTCYNPLVYFAMNNQ 0
0 FRRYFQDLLCCGRRLFDASASVNTCNTSAMPRHSPVFQKPDSDQYNGIQKSREPQMRTTGQNAPYRQWIEMQTIAVVVKADEVNNKFGEVKT* 0

>TMT5_braBel Branchiostoma belcheri (amphioxus) Deut.Ceph.Bran AB050609 12435605 full G? Amphiop5 introns from braFlo
0 MLGIYNVVNATEYGNNTTFAAWDFKRNGTGGEEEVEFFGYDAVAGVIAIIGVVGFVSNGAVVVLFLKFPQLRTPFNLLLLNMAVADLLVSVCGNTLSFASAVRHRWLWGRPGCVWYGFANHLF 1
2 GLVSLISLAVISFLRYRMVVKPKGPGSSYLTYTKVGLAILFIYLYCLLWTTLPIAGWSSYQLE 0
0 GPKIGCSVAWEEHSWSNTSYIVVLFITCLFAPLLIIVYSYYRLWHKVKQ 0
0 GSRNLPAAMRKSSQKEQKIAMMVIVMITCFMVCWLPYGAMALVVTFGGERLISHTAAVVPSLLAKSSTCYNPVVYFAMNSQ 0
0 FRRYFQDLLCCGRRLFDVSQSVVTGNTAMPRNNSQGFRKDDSDQKQDNGLPKQSEGPMCDHSSNESQMEGSRHNTAASQQWIEMQTIAVVVKAVEVDTSAANEP* 0

>TMT_monDom Monodelphis domestica (opossum) Deut.Meta.Dide XM_001372110 full G? syn(+NCK2 -UXS1 +TMT -ST6 GAL2_overlap) -RALY shortened final exon
0 MSNNLTTNLSLEALLSASEDKQRNGLSRTGHTIVAVFLGIILIFGSISNFIVLVLFCKFKVLRNPVNMLLLNISISDMLVCLSGTTLSFASSIQGRWIGGKHGCRWYGFANSCF 1
2 GIVSLISLAILSYERYRTLTLCPGQGADYQKALLAVAGSWLYSLVWTVPPLIGWSSYGTEGAGTSCSVHWTSKSVESVSYIMCLFIFCLVIPILVMVYFYGRLLYAVKQ 0
0 VGKIRKTAARKREYHVLFMVVTAVICYLICWVPYGMIALLATFGPPGVVSPVANVVPSILAKSSTVCNPIIYVLMNKQ 0
0 FYKCFLILFHCQPAQSGPDVSLCPSNVTVIQLGQRKNKDAPGSI* 0

>TMT_macEug Macropus eugenii (wallaby) Deut.Meta.Dipr genomic full G? teleost multiple tissue
0 MSINLTANLSFGTLLPDSEEKQRSGLSRTGHTVTAVFLGLILILGVINNFIVLVLFCKFKVLRNPVNMLLLNISISDMLVCLTGTTLSFASSIRGRWIAGYHGCRWYGFANSCF 1
2 GIVSLISLAVLSYERYRTLTLCPRQGTDYHKALLAVAGSWLYSLIWTVPPLIGWSSYGTEGAGTSCSVHWTSKSVESVSYIMCLFIFCLVIPILFMVYFYGRLLYTVKQ 0
0 VGKIRKSAARKREYHVLFMVVTAVICYLICWVPYGMIALLATFGPPGVVSPVANVVPSILAKSSTVCNPIIYILMNKQ 0
0 FYKCFLILFHCQPASSASDASLCPSKMTVIQLGQRKDKEVPCAIQDLPEVSKKQLCLLSPESNVAPSSGHPQEKMEEKPLSE* 0

>TMT_ornAna Ornithorhynchus anatinus (platypus) Deut.Prot.Mono genomic frag G? teleost multiple tissue
0 GLSRTGHTMVAVFLGIILVFGFMNNLIVLILFCKFKALRNPVNMIMLNISASDMLVCVSGTTLSFASNISGRWIGGDPGCRWYGFVNSCL 1
2 GIVSLISLAVLSYERYRTLTLHPKQSTDYQKAVLAVGASWIYSLIWTIPPLLGWSSYGTEGAGTSCSVHWSSKSPVSVSYIVCLFIFCLVIPVLVMIYCYGRLLYAVKQ 0
0 IGKARKTAARKREYHVLFMVITTVICYLVCWMPYGVTALLATFGQPGTVSPEASVIPSILAKSSTVCNPIIYILMNKQ 0
0 FYKCFLILFHCQPPRAADAPSTYPSQVMVIQLNQRRSRETAGAPQVLLEMKHQTLHLLGPQLHETPSWERSTPVHPE* 0

>TMT_galGal Gallus gallus (chicken) Deut.Saur.Arch XM_001234388 full G? syn(+NCK2 -UXS1 +TMT -ST6 GAL2_overlap +SLC5A7 +SULT1C4)
0 MNHTWTYNLSFGAPTDPVEPRAGLSRNGHTVVAVFLGFILFFGFLNNLIVLILFCKFKTLRNPVNMLLLNISISDMLVCISGTTLSFASNIHGKWIGGEHGCRWYGFVNSCF 1
2 GIVSLISLAVLSYERYSTLTLCNKRSDDYRKALLAVGGSWVYSLLWTVPPLLGWSSYGIEGAGTSCSVRWSSETAESTSYIICLFIFCLVIPVMVMMYCYGRLLYAVKQ 0
0 VGKIHKNTARKREYHVLFMVITTVICYLVCWIPYGVIALLATFGKPGVVTPVASIIPSILAKSSTVCNPIIYILMNKQ 0
0 FYKCFRQLFHCQPPSSTDGEPTCHSKVTVIQLNQKTDGGKLCNNKPRPETDNKVTSLLHPEPGLEPAAKTVPPM* 0

>TMT_taeGut Taeniopygia guttata (finch) Deut.Saur.Arch XM_002192719 full G? teleost multiple tissue
0 MNHTWMYNLSFGAPAHPVEPRAGLSRSGHTVVAVFLGLILFFGFLNNLIVLILFCKFKTLRNPVNMLLLNISVSDMLVCISGTTLSFASNIRGKWIGGDHACRWYGFVNSCF 1
2 GVVSLISLAVLSYERYNTLTLCHKRSDDFRKALLAVAGSWIYSLVWTVPPLLGWSSYGVEGAGTSCSVRWSSESAESTSYIICLFVFCLVVPVMVMMYCYGRLLYAVKQ 0
0 VGKIHKNAARKREYHVLFMVIPTVICYLVCWIPYGVIALLATFGKPGAVTPITSIIPSILAKSSTVCNPIIYILMNKQ 0
0 FYKCFRQLFHCQPPSSTDGEPTCHSKVTVIQLDQRADGGNMCNNEPHPETDSKMTSLLCPETTSKATPPTS* 0

>TMT_anoCar Anolis carolinensis (lizard) Deut.Saur.Lepi genomic full G? teleost multiple tissue syn(+TMT -ST6 GAL2_overlap +SLC5A7)
0 MSELSSNLTFNMSTSIEEPGSGLSRMGHNIVAVFLGLILVFGFLNNLVVLILFCKFKTLRNPVNMLLLNISASDMLVCISGTTLSFVSNIYGRWIGGEHGCRWYGFVNSCF 1
2 GIVSLISLAILSYERYSTLTQTNKRGSDYQKALLGVGGSWLYSLIWTVPPLIGWSSYGLEGAGTSCSVRWTSETLESVTYIICLFIFCLAIPVLVMIYCYARLFYAVKQ 0
0 VGKLRKTSARKREFHVLFMIITTIICYLICWMPYGVIALLATFGRPGLVSPVASVIPSILAKSSTVFNPIIYILMNKQ 0
0 FYKCFLMLLHCQPSSVADGETICQSKVMAIHQNQKAQGGVILKSQVVPQMDEKAICLLSPESSLDPVLESTPQLSKENSFL* 0

>TMT_xenTro Xenopus tropicalis (frog) Deut.Amph.Anur AL773998 full G? syn(-UXS1 +TMT -ST6 GAL2_overlap +SLC5A7) short gastrula frag
0 MSTIKNWTTNISVENSMSYIENDLSLPTEAVLSRTGHTVVAIFLGFILIFGFLNNFVVLILFCKFKTLRTPVNMMLLNISASDMLVCVSGTTLSFTSSIKGKWIGGEYGCQWYGFVNSCF 1
2 GIVSLISLAILSYERYSTLTLYNKGGPNFKKALLAVASSWLYSLVWTVPPLLGWSSYGREGAGTSCSVRWTSESVESVSYIICLFIFCLALPVFVMLYCYGRLLYAVKQ 0
0 VGKIRKIAARKREYHVLFMVITTVICYLLCWLPYGVVALLATFGRPGVISPVASVVPSILAKSSTVFNPIIYILMNKQ 0
0 FYKCFLILFHCHPTSSADGKSICQSNYTVIQLNQKLNNIVAIPGQTQIPESVDKMPCIHRQNNESPSDQMPQSTTEHLISGT* 0

>TMTa_danRer Danio rerio (zebrafish) Deut.Acti.Otoc XM_002192719 full G? syn(-UXS1 +TMT -ST6 GAL2_overlap +GPR89A -pdzk1l)
0 MFFEQADLNYSFNMSEEDRLTLLDEDWSDSPMETLSRAGFIALSVFLGFIMTFGFFNNLVVLVLFCKFKTLRTPVNMLLLNISISDMLVCMFGTTLSFASSVRGRWLLGRHGCMWYGFINSCF 1
2 GIVSLISLVVLSYDRYSTLTVYHKRAPDYRKPLLAVGGSWLYSLIWTVPPLLGWSSYGLEGAGTSCSVSWTQRTAESHAYIICLFVFCLGLPVLVMVYCYGRLLYAVKQ 0
0 VGKIRKTAARKREYHVLFMVITTVVCYLLCWMPYGVVAMMATFGRPGIISPVASVVPSLLAKSSTVINPLIYILMNKQ 0
0 FYRCFRILFCCQRSLLQNGHSSMPSKTTVIQLNRRVNSNAVACTAQISTGTHNHDCSTHVTERSNPPEVIP* 0

>TMTb_danRer Danio rerio (zebrafish) Deut.Acti.Otoc CN506730 full G? teleost multiple tissue syn(-FHL2 +NCK2 +TMT -ST6GAL2_lap) seg dup
0 MFPEETNMSYISNGTDDDLLSALEDWSDTPAEKLSRTGHNVVAVILGSILIFGTLNNLVVLVLFCKFKTLRTPVNMLLLNISVSDMLVCLFGTTLSFAASIRGRWLVGRHGCMWYGFVNSCF 1
2 GIVSLISLAILSYDRYSTLTVYNKRAPDYSKPLLAVGGSWLYSLFWTVPPLLGWSSYGLEGAGTSCSVTWTANTPQSHSYIICLFIFCLGIPVLVMVYCYSRLICAVKQ 0
0 VGRIRKTAARRREYHILFMVITTVVCYLLCWMPYGVVAMMATFGRPGIISPIASVVPSLLAKSSTVINPLIYILMNKQ 0
0 FYRCFLILIHCKHSSLENGQSSMPSRTTGIQLNRRPYSNPVADNAPPSIDLQNDCSTPVSG* 0

>TMT_tetNig Tetraodon nigroviridis (pufferfish) Deut.Acti.Perc genomic full G? syn(-UXS1 +TMT -ST6 GAL2) multiply frameshifted assembly
0 MFSGQAGLNSSFNLSDGRGLEDAPAGRGRLSPTGFVVLSVVLGFIITFGFLNNFIVLLLFCKFKKLRTPVNVLLLNISVSDMLVCLFGTTLSFASSLRGRWLLGRSGCNWYGFINSCF 1
2 GIVSLISLVILSHDRYSTLTVYNKQGINYRKPLLAVGGTWLYSLLWTVPPLLGWSSYGIEGAGTSCSVSWTVQTAQSHAYIICLFIFCLGLPVLVMVYCYSRLLWAVKQ 0
0 VGKIRKTSARKREYHILFMVVTTAACYLVCWMPYGVVAMMATFGPPNIISPVASVVPSLLAKSSTVINPLIYILMNKQ 0
0 FYKCFLILFHCSHWSADNGTTSVPSKITVIQLNRRAYSNTVACADPLSTDALKQCCSAKNASTIEVKLS* 0

>TMT_takRub Takifugu rubripes (fugu) Deut.Acti.Perc genomic full G? teleost multiple tissue
0 MFSGQAGLNYSFNLSDDRELLDAPAGRAKLSPTGFVVLSVVLGFIMTFGFLNNFVVLLLFCKFKKLRTPVNMLLLNISVSDMLVCLFGTTLSFASSIRGRWLLGRIGCSWYGFINSCF 1
2 GIVSLISLVILSYDRYSTLTVYNKQGINYRKPLLAVGGTWLYSLFWTVPPLLGWSSYGIEGAGTSCSVSWTVQTAQSHAYIICLFTFCLGIPILVMIYCYSRLLWAVKQ 0
0 VGRIRKTAARKREYHILFMVVTTAACYLVCWMPYGVVAMMATFGPPNIISPVASVVPSLLAKSSTVINPLIYILMNKQ 0
0 FYKCFLILFHCGHWSADNGNTSMPSKTTAIQLNRRVYSNTVACADQLSTDALKQCCSANTISTKNTSTVEGKLS* 0

>TMT_gasAcu Gasterosteus aculeatus (stickleback) Deut.Acti.Perc genomic full G? teleost multiple tissue
0 MVFGQAGLNHSFNLSDDRELLDTSAGRAKLSPTGFVVLSVMLGFIMTFGFVNNLVVLLLFCKFKKLRTPVNMLLLNISVSDMLVCLFGTTLSFASSLRGKWLLGRSGCSWYGFINSCF 1
2 GIVSLISLVILSYDRYSTLTVYNKAGPDYRKPLLAIGGSWLYSLFWTVPPLLGWSSYGIEGAGTSCSVSWTVQTAQSHAYIICLFTFCLGLPMLVMIYCYSRLLLAVKQ 0
0 VGRIRKTAARRREYHILFMVLTTAACYMLCWMPYGVVAMMATFGPPNIISPVASVVPSLLAKSSTVINPLIYILMNKQ 0
0 FYRCFLILFHCKHWSAENHNTSMPSKTTVIHLNRRVCSNTLPCTAQASTDAANHFCSTSATKHTSPPLQGHGLSLNVLNMIRQENHSHDEAAKNQLDCLT* 0

>TMT_oryLat Oryzias latipes (medaka) Deut.Acti.Perc DK170580 full G? teleost multiple tissue whole embryo
0 MFSGQTGLNFSFNQSDDRELEDTPAGSAKLSQAGFVVLSVVLGFIMTFGFLNNFVVLILFCKFKKLRTPVNMLLLNISVSDMLVCLFGTTLSFASSIRGRWLLGRGGCSWYGFINSCF 1
2 GIVSLISLVILSYDRYSTLTVYNKGGLNYRKPLLAVGGSWLYSLFWTVPPLLGWSSYGLEGAGTSCSVSWTANTAQSHAYIICLFIFCLGLPILVMIYCYSRLLLAVKQ 0
0 VGKIRKTAARKREYHILFMVLTTAACYLLCWMPYGVVAMMATFGPPNIISPVASVVPSLLAKSSTVINPLIYILMNKQ 0
0 FYRCFLILFHCDHWSSENGNTSVPSKTTVIPLNRRIYTNTVAQISTDNAN* 0

>TMT_ictPun Ictalurus punctatus (catfish) Deut.Acti.Otoc FD287269 frag G? teleost multiple tissue 2 transcripts from whole fry
0 WLLGRTGCMWYGFINSCF 1
2 GIVSLISLMILSYERYSTMTVYNNQGPNYRKHLLAVGGSWLYSLIWTVPPLLGWSSYGLEGAGTSCSVSWTDHSPKSHAYIICLFIFCLGLPVLLMVYSYGRLLYAVKQ 0
0 LGKIHKTARRRDYHLLFMITTTVVCYLLCWTPYSVVALMASFGRPGIITPVASIIPSLLAKSSTVINPVIYIFMNKQ 0
0 FYRCFRTLLGYKERSAVPDDHSLMATKNTAIQLKCIMHNNPVPSPAHTPPPFF

>TMTc_xenTro Xenopus tropicalis (frog) Deut.Amph.Anur genomic full G? ciliary uropsin syn(+GPR112 +BRS3 +VGLL1 +TMTx +CD40LG -ARGHGEF7)
0 MLLALNLQNESFLLNLSHGETRDSLPPATGLSRTAHSVVAVCLGCILVLGSLYNSFVLLIFVKFTAIRTPINMILLNISVSDLLVCIFGTPFSFVSSVSGGWLLGQQGCKWYGFCNSLF 1
2 GLVSMISLSMLSYERYLTVLKCTKADMTDYKKSWLCIIVSWLYSLCWTLPPLIGWSSYGLESSGTTCSVVWHSKSSNNISYIVCLFLFCLVLPLFIMIFCYGHIVRVIRG 0
0 VCRINMTTAQKREHRLLFMVVCMVTCYLLCWMPYGLVSLMTAFGKPGMITPTVSIIPSILAKSSTFINPLIYIFMNKQ 0
0 FYRCFIALIKCESGPHHNENISTSRQSREMRLETRCKVQSSIFYTHKARRTKDTTSSPEMQRKLTLTVHYRDDR* 0

>TMTc_danRer Danio rerio (zebrafish) Deut.Acti.Otoc genomic full G? ciliary uropsin syn(+FHL1 +GPR64/112 +TMTx -ARGHGEF7 -RBMX)
0 MVVYIWSLNISSKDTSALNQSGNVSSGDPLEPHDSPPGLSRTGHTVTAVCLGAILLLGCLNNLFVLLVFARFRTLWTPINLILLNISVSDILVCLFGTPFSFASSLYGKWLLGHHGCKWYGFANSLF
2 GIVSLMSLSILSYERYAALLRATKADVSDFRRAWLCVAGSWLYSLLWTLPPFLGWSNYGPEGPGTTCSVQWHLRSTSSISYVMCLFIFCLLLPLVLMIFCYGKILLLIKG 0
0 VTKINLLTAQRRENHILLMVVTMVSCYLLCWMPYGVVALLATFGRTGLITPVTSIVPSVLAKSSTVVNPVIYVLFNNQ 0
0 FYRCFVAFLKCQGEPSVHGQNPQHSSKEDPHVFRPCDGASIHRSAEGPQKKEQHSLSLVVHYTP* 0

>TMTc_tetNig Tetraodon nigroviridis (pufferfish) Deut.Acti.Perc genomic full G? ciliary uropsin syn(-TAF7L +SLC9A7 +FHL1 +TMTx -ARGHGEF7 -RBMX)
0 MVVQPRDCNFSTPDSSVSIFGPSIDARGPWDPQCPGGLSRSSHTAVAVLLGVILVAGILSNSLVLLLFVKYRSLWTPINLILLNINLSDILVCVFGTPFSFAASLQGRWLIGEGGCMWYGFANSLF 1
2 GIVSLVSLSVLSYERCTVVLQPSQVDVSDFRKARFCVGGSWLYALLWTSPPLLGWSSYGPEGAGTTCSVQWQLRSPASVSYVLCLLVFCLLLPFLVMVYSYGRILVAIRR 0
0 VGRINQLTAQRREQHILLMVLSMVSCYMLCWMPYGIMALVATFGKLGLVTPMVSVVPSILAKFSTVVNPIIYMFFNNQ 0
0 FYRCFMAFIRCQKEPEPIQEE* 0

>TMTc_takRub Takifugu rubripes (fugu) Deut.Acti.Perc genomic full G? ciliary uropsin syn(-TAF7L +SLC9A7 +FHL1 +TMTx -ARGHGEF7 -RBMX)
0 MVLQTRECNFSTPDTSVRGPWAPQGPGGMSRTGHTVVAVMLGTILLAGVFGNSVVFLVFVKYRSLRTPINLILLNISLSDILVCVFGTPLSFAASLKGRWLLGERGCEWYGFANSLF 1
2 GIVSLVSLSVLSYERYTVVLQPTQVDVSYFRKAWFCVGGSWLYALFWTLPPLLGWSRYGPEGPGTMCSVQWHLRSPANISYVLCLFIFCLLLPLVVMVYSYGRIWVAVRR 0
0 AGRINLLTAQRREQHILWMVLSMVSCYMLCWMPYGIIALVATLGRLGPISPAVSVVPSILAKFSTVVNPVIYMFFNNQ 0
0 FYRCFMAFVRCQKEPESIQGE* 0

>TMTc_oryLat Oryzias latipes (medaka) Deut.Acti.Perc genomic full G? ciliary uropsin syn(+SLC9A7 +FHL1 +GPR56 +TMTx -ARGHGEF7 -RBMX)
0 MVLHSHNCNFSTKDSSPCSTNSTEPHNPDGLSRTGHTAVAVCLGFILVAGILNNFLTLLVFAKFRSLWTPINLILLNISLSDILVCVLGTPFSFAASVRGRWLIGESGCKWYAFANSLF 1
2 GIVSLVSLSVLSYERYITVLHSSQADLSNFRKAWFCVGGSWLYSLLWTLPPFLGWSSYGPEGPGTTCSIQWHLRSPTSVSYVLCLFIFCLVLPLVLMVYSYGRILVALRR 0
0 VGKINLLAAQRREQRILVMVFSMVSCYILCWMPYGIVALMATFGRKGLVTPLTSVIPSILAKFSTVVNPVIYVFFNSQ 0
0 FYRCLVAFVRCSGDPEEHPTPRTQLSDVVRVQKQNSVSSSSPRLLSDPTDRMLCNHHPDRHVLFVHYTP* 0

>TMTa_oncMyk Oncorhynchus mykiss (trout) Deut.Acti.Salm CU062745 full G? teleost multiple tissue testis new
0 MVVESGNLNFSTDDSSGTNLSPKDSVRDTLTSRQSDLGRTGHTVVAVFLGVIFLLGFLSNLFVLLVFARFQVLRTPINLILLNISVSDMLVCIFGTPFSFAASLYGRWLIGAHGCKWYGFANSLF 1
2 GIVSLVSLAILSYERYSTILCYTKADPSDYKKAWLAIAGAWLYSLVWTVPPFFGWSSYGPEGPGTTCSVQWHQRSSGNISYVTCLFIFCLLLPLLLMMFCYGKILFAIRG 0
0 VAKINQSSAQRRETHVLVMVVSMVSCYLLCWMPYGVVALLATFGQVGLVSPTTSIVPSILAKSSTFLNPVIYGLLNNQ 0
0 FYRCFLAFMSCGSEAAGSHTLHTLPSSRVVGPYGNSPAPEEPGTREPLDGSGTSSKTQTRGPQREKRDLVLVVHYTP* 0

>TMTa_anoCar Anolis carolinensis (lizard) Deut.Saur.Lepi genomic full G? teleost multiple tissue
0 MTVPSISPSCIGVANGVWCSNGGSSSNSHHRHGQEQSLSPTGHLITAICLGVIGSLGFLNNLLVLVLFCRNKVLRSPINLLLMNISLSDLMICIVGTPFSFAASTQGKWLIGPAGCVWYGFANTFF 1
2 GTVSLISLAVLSYERYCTMMGTTEADATNYKKVWMGIFLSWIYSLFWSLPPLFGWSSYGPEGPGTTCSVNWHSRDANNISYIICLFIFCLVIPFIVIVYCYGKLLCAIKK 0
0 VSGVTQGMAQTREQRVLIMVVVMIICFLLCWLPYGIVALIATFGKPGLITPSASIIPSVLAKSSTVYNPVIYIFLNKQ 0
0 FYRCFCALLKCGKKSIASSNKCSSRSTRVCRSIRKQDNFTFVAASAGPPSSEHQDAILSIQNPEPPTDNSPKAKQRVLLVAHYSV* 0

>TMTa_xenTro Xenopus tropicalis (frog) Deut.Amph.Anur genomic full G? teleost multiple tissue scaffold_55
0 MAFHSSSPSCSDSSSVTCRSSIQQYGPENHPNLSPTGHLLVAVFLGVIGSLGFFNNLVVLILFCQYKVLRSPINMLLMNISLSDLMVCILGTPFSFAASTQGHWLIGEIGCIWYGFVNTLF 1
2 GTVSLVSLAVLSYERYCTMLRSTEADLTNYKKAWLGILVSWIYSLVWTLPPLFGWSKYGPEGPGTTCSVNWHSRDANNISYIVCLFIFCLALPFAVIVYCYGRLLFAIKQ 0
0 VSGVSKSSSRAREQRVLIMVIVMVVCFLLCWLPYGVMALVATFGKPGIISPSASIIPSVLAKSSTVYNPIIYIFLNKQ 0
0 FYRCFTALIHCNKHPQVSSNKGSSKTTKIMLTARKLPDANFTVNAASNPPSSSVVKYEADSKTHNGDTKPFKTLVANYVI* 0

>TMTa1_danRer Danio rerio (zebrafish) Deut.Acti.Otoc AF349947 12670711 full G? teleost multiple tissue syn(+PBX3 +TNK2 +TMTa1 -PAP2D +LPPR4)
0 MIVSNLSVLSCRRNSALCLGAVEGHLEASSSYRTLSPTGHILVAVSLGFIGTFGFLNNLLVLVLFGRYKVLRSPINFLLVNICLSDLLVCVLGTPFSFAASTQGRWLIGDTGCVWYGFANSLL 1
2 GIVSLISLAVLSYERYCTMMGSTEADATNYKKVIGGVLMSWIYSLIWTLPPLFGWSRYGPEGPGTTCSVDWTTKTANNISYIICLFIFCLIVPFLVIIFCYGKLLHAIKQ 0
0 VSSVNTSVSRKREHRVLLMVITMVVFYLLCWLPYGIMALLATFGAPGLVTAEASIVPSILAKSSTVINPVIYIFMNKQ 0
0 FYRCFRALLNCDKPQRGSSLKSSSKTKPFRPGRRTDNFTFMVASVGPNQTNPVEDGPPSADNTKPAVLSLVAHYNG* 0

>TMTa_takRub Takifugu rubripes (fugu) Deut.Acti.Perc AF402774 12670711 full G? teleost multiple tissue syn(-CALD1 +TNK2 -RAB18 +ABI1 12670711)
0 MIVSNVSLSGCAGVNGAVCAAEGHQAGGSDRSTLTPTGNLVVSVFLGFIGTFGLVNNLLVLVLFCRYKMLRSPINLLLMNISISDLLVCVLGTPFSFAASTQGRWLIGEAGCVWYGFANSLF 1
2 GVVSLISLAVLSFERYSTMMTPTEADPSNYCKVCLGITLSWVYSLVWTVPPLFGWSSYGPEGPGTTCSVNWTAKTTNSISYIICLFVFCLIVPFLVIVFCYGKLLCAIRQ 0
0 VSGINASTSRKREQRVLCMVVIMVICYLLCWLPYGVVALLATFGPPDLVTPEASIIPSVLAKSSTVINPIIYVFMNKQ 0
0 FYRCFLALLCCQDPRSGSSMKSSSKVATKAKGVTPTGQRRTDFLYMVASLGRPAATIPQLGPSFDATNDFTKPPSSDTIKPVVVSLAAHCDG* 0

>TMTa_tetNig Tetraodon nigroviridis (pufferfish) Deut.Acti.Perc genomic full G? teleost multiple tissue
0 MIASNASVSGCAGVHGAACAADAPPAGGSHRSSSSLTPTGNLVVSVFLGLIGTSGLVSNLLVLVLFCRFKVLRSPINLLLVNISVSDLLVCVLGTPFSFAASTQGRWLIGAAGCVWYGFVNSLF 1
2 GIVSLISLAVLSFERYSTMMTPTEADSSNYCKVCLGIGLSWVYSLLWTVPPLLGWSSYGPEGPGTTCSVNWTAKTANSVSYIICLFVFCLILPFLVIVFCYGKLLCAIRQ 0
0 VSGVNASMSRRREQRVLFMVVVMVICYLLCWLPYGVVALLATFGPPGLVTPAASIIPSILAKSSTVINPVIYVFMNKQ 0
0 FSRCFLSLLCCEDPRSSTSLRSSSRVTTKAVRGGTLTGQRRTNHLLYMVAALGRPVATAMPQLGPSFDATYDITKAPSSDNHQPVVVSLEAHG* 0

>TMTa_gasAcu Gasterosteus aculeatus (stickleback) Deut.Acti.Perc genomic full G? teleost multiple tissue syn(+TNK2 +ENC)
0 MIVSNLSLSGCAGVSSALCAAAGEGHLSGGSHRNTLTPTGHLVVAVCLGFIGTLGLMNNLLVLVLFCRYKMLRSPINLLLINISISDLLVCVLGTPFSFAASTQGRWLIGEGGCVWYGFANSLF 1
2 GIVSLISLAVLSYERYSTMVAPTEADSSNYHKISLGITLSWVYSLIWTAPPLFGWSHYGPEGPGTTCSVDWTARTANSISYIICLFVFCLIVPFLVIVFCYGKLLCAIRQ 0
0 VSGINASLSRKREQRVLFMVVIMVVCYLLCWLPYGIMALMATFGPPGLITPVASIIPSVLAKTSTVINPVIYVFMNKQ 0
0 FYRCFKALLRCEAPRPSSSLKSSSKVPTKAMRGAAVTGPRHTNNFLFVVASLGRPVATIPQLGPSVEPTIDVTGGPSSDNNKPVIVSLVAQCDG* 0

>TMTa_oryLat Oryzias latipes (medaka) Deut.Acti.Perc genomic frag G? teleost multiple tissue syn(SLC12A3) two contigs frag
0 MLVSNVSLGGCAEFNSALCAGAGEEHLGGGSYRTTLTPTGHLIVAVCLGFIGTFGLVNNLLVLVLFCRYKILRSPINLLLINISISDLLVCVLGTPFSFAASTQGRWLIGEGGCVWYGFANSLC 1
2 GIVSLISLAVLSYERYSTMMTPAEADSSNYRKISLGIILSWGYSLLWTLPPLFGWSHYGPEGPGTTCSVDWTAKTANNISYIICLFVFCLIVPFMVIVFCYGKLLYAIKQ 0
0 VSGINVSVSRKREQRVLFMVVIMVICYLLCWLPYGIMALLATFGPPDLVTPEASIIPSVLAKTSTAINPVIYVFMNKQ 0

>TMTa_pimPro Pimephales promelas (minnow) Deut.Acti.Otoc DT200813 frag G? teleost multiple tissue
0  GHLVVAVCLGFIGTfGFLNNTLVLILFCRYKVLRSPMNYLLVSIAVSDLLVCVLGTPFSFAASTQGRWLIGRAGCVWYGFINSCL 1
2 GVVSLISLAVLSYERYCTMMGATQADSTNYKKVAMGIAFSWIYSMVWTLPPLFGWSCYGPEGPGTTCSVNWAARTANNVSYIICLFFFCLILPFIVIVYSYGRLLQAITQ 0
0 VSRINTVVSRKREQRVLFMVITMVVCYLLCWLPYGIMALLAAFGRPGLVTPAASIVPSVLAKTSTVINPIIYIFMNKQ 0
0 FCRCFHALIMCTTPQRGSSFKNSSKVTKTLRTVRRANGQNVTFAVASAGHPTICAPH

>TMTc_danRer Danio rerio (zebrafish) Deut.Acti.Otoc CO927631 full G? teleost multiple tissue syn(+TNK1 +TMTb -MYEOV2)
0 MIESNVSRSCEWCAGGGEGTGAHLDENHSDHSLSPTGHLVVAVCLGFIGTFGFLNNTLVLVLFCRYKVLRSPMNCLLISISVSDLLVCVLGTPFSFAASTQGRWLIGRAGCVWYGFINSFL 1
2 GVVSLISLAVLSYERYCTMMGSTQADSTNYRKVVIGIAFSWIYSMVWTLPPLFGWSCYGPEGPGTTCSVNWAARTPNNVSYIVCLFVFCLILPFIVIVYSYGRLLQAITQ 0
0 VSRINTVVSRKREQRVLFMVVTMVVCYLLCWLPYGIMALLATFGHPGLVTPAASIVPSLLAKSSTVINPIIYIFMNKQ
0 FCRCFHALIMCTTPERGSSFKNSSKVTKTLRTVRRANGQNVTFAVASAVHRTPYSDRQKSSSEGEKLPPATGQGTSKPVVSLVAYYNG* 0

>TMTb_takRub Takifugu rubripes (fugu) Deut.Acti.Perc genomic full G? teleost multiple tissue syn(+TFRC +TMTb +CHES1 -MYEOV2 -ARHGAP21)
0 MIVCNVSLSCAHCPGEGTAANDAYAQASGSLATPTLSQRGHLVVAVCLGFIGTVGFLSNFLVLALFCRYRALRTPMNLMLVSISASDLLVSVLGTPFSFAASTQGRWLIGRAGCVWYGFVNACL 1
2 GIVSLISLAVLSYERYCTMVSSTIASNRDYRPVLGGICFSWFYSLAWTVPPLLGWSRYGPEGPGTTCSVDWRTQTPNNISYIVCLFTFCLLLPFFVILYSYGKLLHTIRQ 0
0 VRRVSSTVTRRREHRVLVMVVAMVVCYLICWLPYGVTALLATFGPPNLLTPEATITPSLLAKFSTVINPFIYIFMNKQ 0
0 FYRCFRAFLNCSTPKRDSTVRTFTRISLRALRQDQQQKGSALAPSSARPTPNSIHESSLKGSHSTPSNGGAAAAKSPAANRSKPKLILVAHYRE* 0

>TMTb_tetNig Tetraodon nigroviridis (pufferfish) Deut.Acti.Perc genomic full G? teleost multiple tissue
0 MIVCNLSLSCAHCPGGGAAATDAYAYAEAPGSLAPPTLSQRGHLVVAVCLGAIGTVGFLSNLLVLALFCRFRALRTPMNLMLVSISASDLLVSVLGTPFSFAASTQGRWLLGRAGCVWYGFVNACL 1
2 GIVSLISLAVLSYERYCTMMASTMASNRDYRPVLLGICFSWFYSLAWTVPPLLGWSRYGPEGPGTTCSVDWRTQTPNNISYIVCLFAFCLLLPFCVILYSYGKLLHTIRQ 0
0 VSSVSSAVTRRREHRVLVMVVAMVVCYLICWLPYGVTALLATFGPPNLLTPEATITPSLLAKFSTVINPFIYIFMNKQ 0
0 FYRCFRAFLSCSSPERGSTVRTFTRISLRAVCQRKQQRVSAPAASSACPTPNSIHHSSRKGSHSASSNSGTAAAAKTPAANSSKPKLILVVHYRE* 0

>TMTb_gasAcu Gasterosteus aculeatus (stickleback) Deut.Acti.Perc genomic full G? teleost multiple tissue
0 MIVCNVSLSCVHCPGGGAGGTAATATGAYEEVSDSLPAPSLSPKGHLVVAVCLGFIGTFGFLSNFLVLALFCRYRALRTPMNLLLVSISASDLLVSMVGTPFSFAASTQGRWLIGRAGCVWYGFVNACL 1
2 GIVSLISLAVLSFERYSTMVKPTVADGRDFRPALGGIAFSWLYSVAWTVPPLLGWSEYGPEGPGTTCSVDWKTQTANNISYIVCLFVFCLVLPFCVILYSYSRLLQAIRQ 0
0 VSVVSSVVTRHREQRVLAMVVVMVACYLVCWLPYGVAALLATFGPRDLLSPEASITPSLLAKFSTVVNPFIYIFMNKQ 0
0 FYRCFRAFLSCSTPERGSTLKTFSRPTKTLRAGRHEKGRRVSAAAPSTAQPTRNSAPRSSQGANHASATPPPSPADGRCAAAGAAKPKRTLVAHYRE* 0

>TMTb_oryLat Oryzias latipes (medaka) Deut.Acti.Perc genomic full G? teleost multiple tissue
0 MIVPNASLSCAHCDGDAAEQDAPGSAAAPSLSPTGHLVVAVCLGLIGTCGFLSNLLVLALFCRYRALRTPMNLLLVSISVSDLLVSVLGTPFSFAASTQGRWLIGRAGCVWYGFINACL 1
2 GIVSLISLAVLSYERYSTVMTPNMADGRDFRPALGGICFSWLYSVAWTVPPLLGWSRYGPEGPGTTCSVDWKTQTPNNISYIICLFTFCLLLPFGVIVYSYGKMLRVIRQ 0
0 VRSMSSVVTRRREQRVLVMVVTMVVCYLVCWLPYGIAALLATFGPRDLLTPAASITPSLLAKFSTVINPLIYIFMNKQ 0
0 FYRCFWAFFCCSTPEQVSTLRTFSRVTKTIRTFRQERELHVSAPAPSSGLPTPNSIQKGNNHVDPSSINQACAASDSPDSRKPKVVLVAHYQE* 0

>TMTa1_calMil Callorhinchus milii (elephantfish) Deut.Chon.Holo genomic frag G? teleost multiple tissue exons 1,2,3
0 MLNSSPNSSPSLPLSQVGWTGLSRTGLTVVAVCLGIIMVLGFLNNLLVLVLFCKYKVLRSPMNMLLLNISVSDMLVCICGTPFSFAASVQGRWLVGEQGCKWYGFANSLF 1
2 GIVSLMSLTILSYDRYITITGTTEADITNYNKTIVGIALSWIYSLMWTLPPLFGWSNYGPEGPGTTCSVNWQSKEVSSKSYIICLFIFCLLMPFLVIVYCYGKLVLAVRK 0
0 VSANNSMGRTRENKLLIMVTFMIICFLLCWLPYGIVALLATFGSPGLITPTASIIPSVLAKTSTVYNPIIYIFMNKQ 0

>TMTa2_calMil Callorhinchus milii (elephantfish) Deut.Chon.Holo genomic frag G? teleost multiple tissue exons 1 and 3
0 MMAHSANISTTLNASDHAPNLAGLSQSGHTTVAVFLGIILVLGCVNNLLVLLLFVCFKEIRTPLNMILLNISLSDLSVCVFGTPFSFAASIYRRWLIGHKGCKWYGFANSLF 1
0 VGKINQMTAQTREHRILLMVISMVTFYLLCWLPYGTVALIGTFGNADLITPTCSVIPSILAKSSTVINPVIYVIMNKQ 0

>TMTx_braFlo Branchiostoma floridae (amphioxus) Deut.Ceph.Bran XM_002207814 frag G? assembly duplication no N-term even in v2
0 VAAILALIGVLGIVNNSTTLYLVGRYKQLRTPFNILMVNLSVSDLLMCVLGTPFSFVSSLHGRWMFGHSGCEWYGFICNFL 1
2 GIVSLITLTVISYERYLLMKRLPNERILSYRAVALAVVFIWCYSLLWTAPPLVGWSSYGPE 0
0 GYGISCSVNWESRTANDTSYIVAYFVGCLVFPVAIIVISYTRLILYMRQ 0
0 APSAPMQMLVRREKRVTKMVVVMIMGFTICWTPYTIVALIVTCGGEGIITPAAATVPALFAKSSVVYNAAIYVAMNNQ 0
0 FRKCFLRSLNCRSQPRDPSSQQYTLKTNQVGMSTSGSQAARTADRIKTVHVATANPQDHRSSSGQAVEDNGGFRKSLTHSLPLNSISTLLEAEK* 0

>TMTy_braFlo Branchiostoma floridae (amphioxus) Deut.Ceph.Bran FE572481 full G? teleost multiple tissue gastrula XM_002222645 flawed allele dup new
0 MASAGQNVTFPAIDTMAPTPEALTSDPTTPAYFTTEQHLLMAVWLGFIGSFGFVTNLLTVLVFWCFKSLRTPFHLYLGGIALSDLLVAALGSPFAVASAVGERWLFGRAVCVWYAFVNYFL 1
2 SIVSIVTMATMSFSRYWVIIRPQSAPRLDTVYGACVVNALAWCYSFFWTIMPVLGWSRFTQ 0
0 VAAMTVCSLDWDHHTPLSKSYIPVAFLTCLFLPLGVIIFSVFKTTMHLRR 0
0 AAEVEDEVPNEVRAGRKTTRITLVMAGCWLVAWLPYACMALVIAAGGRVSPTVEVLATKFAKTSYIVNTIIYLVMEKE 0
0 FRKSLVLLLFCGRDPFDIQIEQPAYEKADVYVERLVTAEPMVEMEAVNVRPAQQEPARAPFGTPL* 0

>TMT1_strPur Strongylocentrotus purpuratus (sea_urchin) Deut.Echi.Eleu XM_001177470 16311335 full G? teleost multiple tissue PIN-type introns no cdna no sacKow
0 MSNLMTGLVTNVNALSGIGNETPTTIGLSSLVVPVSRTTYNYLTVYTGFLTIFGILNNGIVMILFARFPSLRHPINSFLFNVSLSDLIISCLASPFTFASNFAGRWLFGDLGCTLYAFLVFVA 1
2 GTEQIVILAALSIQRCMLVVRPFTAQKMTHRWALFFISLTWIYSLIICVPPLFGWNRYTYEGPGT 1
2 ACSVAWNSPSPGDTSYIIFIFVLVLVIPFGIIIFCYGLLVYAVKK 0
0 ISRTQAALSSEAKADRKVSKMIFIMILFFLIAWTPYTGFSLYVTFGKNVVITPLAGTFPPFFAKLCTIHNPIIYFLLNKQ 0
0 FKDALIQLFCCGENPFDRDESEHEGRGGRHRHRTAPSATAHIGGRGRASSLPTATSMLDIPQAASTAASSSGKTQNKESLEKGPSTSETTNKRVFELSSKIQKFEISEKNNTPSSSELPGASSLSGALMPPRRAMKNQVGCLPPVDN* 0

>TMT1_plaDum Platynereis dumerilii (ragworm) Ecdy.Anne.Poly CT030681 16311335 full G? 5 exons
0 MDDLGFLGNSSVNYTVPLLQEDPLLLRILYFGPTSYVITAIYLCIVGVIGTLSNGVIMYLYFKDKSLRSPMNLLFVNLAMSDFTVAFFGAMFQFGLTCTRKYMSPGMALCDFYGFITFLG 1
2 GLASEMNLFIISVERYLAVVRPFDVGNLTNRRVIAGG 1
2 VFVWLYSLVFAGGPLVGWSSYRPEGLGTWCSISWQDRSMNTMSYVTAVFLGCYFFPVSIIIFCYFNVWRKVKE 0
0 AADAQGGAGTAGKAEKSIFRMSVIMVTCYLTAWTPYAIVCLIASYGPPNGLPIYAEVLPSLFAKSSQVYNPIIYVLMNKP 0
0 YRSALVSLVCRGRNPFDEAGGTAGGTTAKDETLGKGNKVAAA* 0

>TMT2_plaDum Platynereis dumerilii (ragworm) Ecdy.Anne.Poly AY692353 15514158 full G? new genomic
0 MDGENLTIPNPVTELMDTPINSTYFQNLNAETDGGNHYIYNAFTATDYNICAAYLFFIACLGVSLNVLVLVLFIKDRKLRSPNNFLYVSLALGDLLVAVFGTAFKFIITARKTLLREEDGFCKWYGFITYLG 1
2 GLAALMTLSVIAFVRCLAVLRLGSFTGLTTRMGVAAMA 1
2 FIWIYSLAFTLAPLLGWNHYIPEGLATWCSIDWLSDETSDKSYVFAIFIFCFLVPVLIIVVSYGLIYDKVRK 0
0 VAKTGGSVAKAEREVLRMTLLMVSLFMLAWSPYAVICMLASFGPKDLLHPVATVIPAMFAKSSTMYNPLIYVFMNKQ 0
0 FRRSLKVLLGMGVEDLNSESERATGGTATNQVAAT* 0

>TMT_terTra Terebratalia transversa (lampshell) Loph.Brac.Rhyn HQ679623 full 21362157
MSTASSGTVTTVMESNITTLSPFTTRAPMFSDGANVIIVLVLFVTAILGFFMNGSVLIIFYRKKELRSPTNMFIISMAFNDLMMSILGNPFAAVSNLHHR
WIFGDAACVWYGFIMFFLGLNGIYHLTAIAFDRYIVIAKPLLSSKITTRVAALAISVCWFGAFLWSVFPVFGWSSYVEEGEHSSCSINWISQSIVDSSYI
ISIFIFCFFLPILLVIFSYFHVYMTVRTIAKSNTFGKDSKITKKNEAVERKMAKMVIIMITVFFGSWSPYAIVSMFVAFGDGSSLPAAAIAAPAIIAKSA
MIWNPIIYVLMNVQFRSGFAEMYPCFAVCANTDGGKVKVERPPTVQDNIGDDNTEMSDVRSAVPPAPTSNILKVAPAPDTTKADVHTSETGEQSIAMSIA
RMSVRHKVESRTPVEQMNAVEV*

>TMT1_anoGam Anopheles gambiae (mosquito) Ecdy.Inse.Dipt XM_312503 full G? GPROP11 pteropsin GPROP11 head-to-head tandem GPROP12
0 MYDVTDAAAINSDHQELMAPWAYNGAAVTLFFIGFFGFFLNIFVIALMYKDVQ 0
0 LWTPMNIILFNLVCSDFSVSIIGNPLTLTSAISHRWLYGKSICVAYGFFMSLL 1
2 GIASITTLTVLSYERFCLISRPFAAQNRSKQGACLAVLFIWSYSFALTSPPLFGWGAYVNEAANIS 2
1 CSVNWESQTANATSYIIFLFIFGLILPLAVIIYSYINIVLEMRK 0
0 NSARVGRVNRAERRVTSMVAVMIVAFMVAWTPYAIFALIEQFGPPELIGPGLAVLPALVAKSSICYNPIIYVGMNTQ FRAAFWRIRRSNGVAGQPDSNNTNNSNRDKESARHTAKEGL
ECSLDFCHWTVRGTRVSISSAERNVPAPAARERSGGHSVTGSREESRDRHVTLKTMLSVGPRSPSSVAPVAADCSTTDVPTSGDGSVRIVRQDSELSVIHDGGGGGGGSSSRVLVIKSQKPRSNML* 0

>TMT2_anoGam Anopheles gambiae (mosquito) Ecdy.Inse.Dipt XM_312502 full G? GPROP12 pteropsin encephalopsin GPROP12
0 MNDAPNDVAASAVDYEDLMAPWAYNASAVTLFFIGFFGFFLNLFVIALMCKDMQ 0
0 LWTPMNIILFNLVCSDFSVSIIGNPLTLTSAISHRWIFGRTLCVAYGFFMSLL 1
2 GITSITTLTVLSYERYCLISRPFSSRNLTRRGAFLAIFFIWGYSFALTSPPLFGWGAYVQEAANIS 2
1 CSVNWESQTKNATTYIIFLFVFGLVVPLIVIVYSYTNIIVNMRE 0
0 NSARVGRINRAEQRVTSMVAVMIVAFMVAWTPYAIFALIEQFGPPELIGPGLAVLPALVAKSSICYNPIIYVGMNTQ FRAAFSRVRNKGQQAAADQNTTTMQRELTKSSRDMVECSF
DFCRKKSRFKISLVKPTAPLAVVDVSSTSHRDKGTSRSPLDQTVLNETNEDVGRERSGGGGGGGAYAGTRFVRPDFELSVINSGKSILIKSKNFRSNLL* 0

>TMT_aedAeg Aedes aegypti (mosquito) Ecdy.Inse.Dipt XM_001650752 full G? pteropsin genome frameshifted
0 MESWAYVASAVTLFFIGFFGFFLNLFVIALMCKDVQ 0
0 LWTPINIILFNLVCSDFSVSIIGNPFTLTSAISRHWIFGRTVCIAYGFFMSLL 1
2 GITSITTLTVLSYERFCLISHPFSSRSLSRRGAVFAILFIWSYSFALTSPPLFGWGAYVNEAANIS 2
1 CSVNWESQTLNATSYIIFLFVFGLVVPLVVIVYSYTNIVVNMKR 0
0 NAARVGRINRAEKRVTRMVFVMVLAFMIAWTPYAVFALIEQFGPTDIISPALGVLPALIAKSSICYNPIIYVGMNTQFRAAFNRVRNNESVDNNTITNQKDITMNTSK
EIVECSFDFCRKKRLKIKLQSNAKSKNNNNNSRNQSIADPSSTSNGDDLDQPSPAQTVLNSTVANSGSVASFGPKKRLRSDFELSVISSGKSILIKSNTFRSNLV* 0

>TMT_culPip Culex pipiens (mosquito) Ecdy.Inse.Dipt genomic full G? pteropsin
0 MPPWAYVATAVVLFFIGFFGFFLNLFVIALMCKEVQ 0
0 LWTPMNIILLNLVCSDFSVSIVGNPFTLSSAISHRWLFGRKLCVAYGFFMSLL 1
2 GITSITTLTVLSYERFYLISRPFSSRSLSRRGALGAVLLIWCYSFALTSPPLFGWGAYVNEAANIS 2
1 CSVNWETQTLNATTYIIYLFVFGLVVPLTVIVYSYTNIIVNMKK 0
0 NAARVGRINRAEKRVTTMVAVMVIAFMVAWTPYSVFALMEQFGPPDVIGPGLAVLPALIAKSSICYNPIIYVGMNTQFRAAFNRVRHDPGDMANTTTNQKELT
RSSRDVASVDCSFDFCRKKNRLKMKLHNSIHRSAAIKAGRSQSPHSESERSSSGATQERSTRVQTMLNATVDSRSISGSTGKLMKSDFELSVINSGKSILIKSNTFRSNLV* 0

>TMT_triCas Tribolium castaneum (flour_beetle) Ecdy.Inse.Cole genomic full G? pteropsin
0 MKNFNSTEIGDELLIPVEGYIAAAVVLFCIGFFGFSLNLTVIIFMLKERQ 0
0 LWSPLNIILFNLVVSDFLVSVLGNPWTFFSAINYGWIFGETGCTIYGFIMSLL 1
2 SITSITTLTVLAFERYLLIARPFRNNALNFHSAALSVFSIWLYSLSLTIPPLIGWGEYVHEAANLS 2
1 CSVNWEEKSPNSTSYILYLFAFGLFLPLVIITFSYVNIILTMRR 0
0 NAAFRVGQVSKAENKVAYMIFIMIIAFLTAWSPYAIMALIVQFGDAALVTPGMAVIPALLAKSSICYNPVIYIGLNAQVKGAKWVSGLIYLFQFQQAWMQKWKKNRR
GSDALGTSRVMLETIHQACRDEKTDKLLEKKTKFCKDFETDVSML* 0

>TMT_apiMel Apis mellifera (bee) Ecdy.Inse.Hyme NM_001039968 16291092 full G? AmLop2 pteropsin ciliary compound eye not ocelli clock
0 MSLNRSTMEHVIYEDQVSPVMYIGAAIALGFIGFFGFTANLLVAIVIVKDAQILWTPVNVILFNLV 0
0 FGDFLVSIFGNPVAMVSAATGGWYWGYKMCLW 2
1 YAWFMSTLGFASIGNLTVMAVERWLLVARPMQALSIR 2
1 HAVILASFVWIYALSLSLPPLFGWGSYGPEAGNVSCSVSWEVHDPVTNSDTYIGFLFVLGLIVPVFTIVSSYAAIVLTLKKVRKRA 1
2 GASGRREAKITKMVALMITAFLLAWSPYAALAIAAQYFN 0
0 AKPSATVAVLPALLAKSSICYNPIIYAGLNNQFSRFLKKIFDARGSRTAVPDSQHTALTALNRQEQRK* 0

>TMT_bomTer Bombus terrestris (bumblebee) Ecdy.Inse.Hyme 454SRA full G? pteropsin presumed ciliary compound eye not ocelli clock
0 MSLNRSTVDNVVYDAEDQVSPMVYVAAAIALGFIGFFGFTMNLLVAIVIVKDAQILWTPVNVILVNLV 0
0 VGDFLVAAFGNPVAMISAITGGWYWSYEMCLW 2
1 YAWFMSTLGFASIGNLTVMAVERWLLVARPMKALSIR 2
1 HAITLGIFVWFYALCLSLPPLFGWGSYGPEAGNVSCSVSWEVHDPLTKSDSYIAFLFVFGLIIPVLVISSSYVAIIVTLRKVRKRA 1
2 GASGRREAKITKMVALMITAFLLAWSPYAALAIAAQYFD 0
0 AKPSASVAVLPALLAKSSICYNPIIYAGLNSQFPRSLKKIFDVRIARSSLPDSQNTALTLLNRQEQRN* 0

>TMT_attCep Atta cephalotes (ant) Ecdy.Inse.Hyme wgs ADTU01001608 full 63% bee
0 MSLNLSVEEQLSIDIYIFAAIALGFIGFL 21 GFFLNLLVIITVLKNANVLWTPNNVVLINMV 0
0 IGDFLVAALGNPFTMTSAIAGEWFWSHEVCLW 2
1 YAWFMTTMGFASIGNLTVMAMERFLLVTCPMKTLSIR 2
1 HAYILAILVWMYALSLSLPPFFNWGIYGPEAGNISCSVSWEIHDPYMHNDTYIGFLFIVGFFLPVTIIISSYYGIIKTLRKIRKRV 1
2 GAKNRREKKVTKMVYLMILAFLIAWSPYAVLALATQYFYV 0
0 QTSHILAVLPALLAKSSICYNPIIYASMTAQFPTWKKMFSINRNNTKSKQRHGSELQIK* 0
 
>TMT_rhoPro Rhodnius prolixus (kissing_bug) Ecdy.Inse.Hemi ACPB01038515 full G? pteropsin ACPB01038514
0 MLMPSAGFLAASIILFLIGFLGFFGNLIVIIIMCRDKN 0
0 LWTPVNFILFNVIVSDFSVAALGNPFTLASAIAKRWFFGQSMCVAYGFFMALL 1
2 GITSINSLTVLALERYLIVSQPVSHGSLSRPTASDIVGSIWLYSFVITiPPLVGWGEYGLEAANIS 2
1 CSINWETRSHSSTSYILFLFTFGFFIPIIVISYSYMNIILTMKK 0
0 STMNAGRVNKAESRVTWMIFVMIFAFFLAWTPYAILALMIAFFDSNVSPAIATIPAIFAKTSICYNPFIYAGLNTQ 0
0 FRQSWRRVLGGKREDSTTMATATSFGLNSKRYKEVSCVIDVKGKDKIKLSALNKSTATETAI* 0

>TMT_acyPis Acyrthosiphon pisum (aphid) Ecdy.Inse.Hemi genomic full G? pteropsin two contigs, 1st exon very wrong in XM_001952259
0 MNGEYAQPQHISDAIYLGAAIVLSIIGIVGFIFNTCVIFIMIRDTR 0
0 LWTPQNVIIFNLATSDLAVSVLGNPVTLAAAITKGWIFGQTICVIYGFFMALF 1
2 GIASITTLTVLAYDRYLMIRYPFSSSRLTKETALYAIAGIWIYAFAVTGPPLFGWNRYVNESANIS 2
1 CSIDWESGEHSNYVIYIFVFGLFLPVTVIIYSYVSLVVTVRK 0
0 AEKIIGQATKAECRVAIMVAVMILAFLTAWMPYSVLALMIAFGGVHISPVVSIIPALCAKSSICWNPIIYIGLNTQ 0
0 FRSAWKRFLNIQDTLSEVSLDADITTGMTKLMTGHQELPAHPMNNGDASHPPGLIMCCLAHDEHRQSATYADRYECNLEMKSCNPQTLGRRPETDIGDVSL* 0

>TMT_bomMor Bombyx mori (moth) Ecdy.Inse.Lepi BY930435 frag G? ovary cDNA
0 MPRWGYVASAFVLFLIGFFGFFLNLMVILLMFKDRQ 0
0 LWTPLNIILFNLVCSDFSVSVLGNPFTLISALFHRWIFGHTMCVLYGFFMALL 1
2 GITSITTLTVISFERYLMVTRPLTSRHLSSKGAVLSIMFIWTYSLALTTPPLLGWGNYVNEAANIQ 2
1 CSVNWHEQSTNTLTYIMFLFAMGQILPLSVITFSYVNIIRTLKR 0
0 NSQRLGRVSRAEARATAMVFIMIIAFTVAWTPYSLFALMEQFATEGI 0
0 VSPGASVIPALVAKSSICYDPLIYVGMNTQ 0
0 FR
 
>TMT_helVir Heliothis virescens (moth) Ecdy.Inse.Lepi GR968759 frag G? pteropsin pheromone gland
0 MPRWGYVVSAFVLFLIGFFGFFLNLMVILLMFKDRQ 0
0 LWTPLNIILFNLVCSDFSVSVLGNPFTLISALFHRWIFGKTMCVLYGFFMALL 1
2 GITSITTLTVISFERYMMVTRPLNSRHLSSKGAIMSIVF

>TMTa_dapPul Daphnia pulex (water_flea) Ecdy.Crus.Bran genomic full G? pteropsin retained intron?
0 MPVWVYWSASAYLLFISIAGLFMNIVVVVIILNDSQ 0
0 KMTPLNWMLLNLACSDGAIAGFG 2
1 TPISAAAALKFTWPFSHELCVAYAMIMSTA 1
2 GIGSITTLTVLALWRCQHVVWCPTNRNSNFTDPNGRLDRRQGALLLTFIWTYTLIVTCPPLFGWGRYDREAAHIS 2
1 CSVNWESKMDNNRSYILYMFAMGLFIPLMAIFVSYISILLFIHK 0
0 SQQTSNNSDTVEKRVTFMVAVMIGAFLTAWTPYSIMALVETFTGDNVTNDSVSSEIKFYAGTISPAVATVPSLFAKTSAVLNPLIYGLLNTQ 0
0 FRTAWEKFSSRFLGRKKRHQRSQMAMGVSHKRRRDYLRTLLNRPASDEPAIVQHPSTKEMASSQAVSCVVVSNLDVPRAPNNSYVTVNDE* 0

>TMTb_dapPul Daphnia pulex (water_flea) Ecdy.Crus.Bran genomic full G? pteropsin long tail IGQDNHSTYYSSRINNATNFSSAFPDGDLSY intron?
0 MPTWAYRLTAAYLLLISVLGLIMNVVVVIVILNDSQ 0
0 RMTPLNWMLLNLACSDGAIAGFG 2
1 TPISTAAALEFGWPFSQELCVAYAMIMSTA 1
2 GIGSITTLTALAIWRCQLVVCCPAKRKSAFTNHSGRLGCRQGVILLVIIWIYALAITCPPLFGWGRYDREAAHIs 2
1 CSVNWESKTNNNRSYILYMFCMGLVVPLAVIIISYVRILRVVQK 0
0 NQQQSGNVHRHRRDAAEKRVTMMVACMIAAFMAAWTPYSILALFETFIGQDNHSTYYSSRINNATNFSSAFPDGDLSYVGTISPAFATIPSLFAKTSAVLNPLIYGLLNTQ 0
0 FRLAWERFSLRFLGRFQCHRTQGVSGQHGANHHKTRRNVRKYLPNCYGDSRSLKPTPTVHLPMKEMVVSHAEQKVKTAQEQASSSVTKITTIPLISSDNQTIVSCPSSIMAN
CQQHETNQANHQQAARPDKVVDHQHLLQPNRLSSLLSLSLPSVLISTPNLPCSAQRQSAAEDQAMATCQQMTSGRIRDQQQQSDSFVVVGLLSRSADCYHHHTGDVEQFVFLDSTVDELGLTARSASP* 0

>MEL1_homSap Homo sapiens (human) Deut.Euth.Euar NM_033282 full Gq OPN4 melanopsin syn(-GRID1 -WAPAL +LDB3 +BMPR1A)
0 MNPPSGPRVPPSPTQEPSCMATPAPPSWWDSSQSSISSLGRLPSISPT 0
0 APGTWAAAWVPLPTVDVPDHAHYTLGTVILLVGLTGMLGNLTVIYTFCR 2
1 SRSLRTPANMFIINLAVSDFLMSFTQAPVFFTSSLYKQWLFGET 1
2 GCEFYAFCGALFGISSMITLTAIALDRYLVITRPLATFGVASKRRAAFVLLGVWLYALAWSLPPFFGW 1
2 SAYVPEGLLTSCSWDYMSFTPAVRAYTMLLCCFVFFLPLLIIIYCYIFIFRAIRETGR 2
1 ALQTFGACKGNGESLWQRQRLQSECKMAKIMLLVILLFVLSWAPYSAVALVAFAG 2
1 YAHVLTPYMSSVPAVIAKASAIHNPIIYAITHPKYR 2
1 VAIAQHLPCLGVLLGVSRRHSRPYPSYRSTHRSTLTSHTSNLSWISIRRRQESLGSESEV 0
0 GWTHMEAAAVWGAAQQANGRSLYGQGLEDLEAKAPPRPQGHEAETPGK 0
0 TKGLIPSQDPRM* 0

>MEL1_panTro Pan troglodytes (chimpanzee) Deut.Euth.Euar genomic full G? OPN4 melanopsin
0 MNPPSGPRVPPSPTQEPSCMATPAPPSWWDSSQSSISSLGRLPSISPT 0
0 APGTWAAAWVPLPTVDVPDHAHYTLGTVILLVGLTGMLGNLTVIYTFCR 2
1 SRSLRTPANMFIINLAVSDFLMSFTQAPVFFTSSLYKQWLFGET 1
2 GCEFYAFCGALFGISSMITLTAIALDRYLVITRPLATFGVASKRRAAFVLLGVWLYALAWSLPPFFGW 1
2 SAYVPEGLLTSCSWDYMSFTPAVRAYTMLLCCFVFFLPLLIIIYCYIFIFRAIRETGR 2
1 ALQTFGACKGNGESLWQRQRLQSECKMAKIMLLVILLFVLSWAPYSAVALVAFAG 2
1 YAHVLTPYMSSVPAVIAKASAIHNPIIYAITHPKYR 2
1 VAIAQHLPCLGVLLGVSRRHSRPYPSYRSTHRSTLISHTSNLSWISIRRRQESLGSESEV 0
0 GWTHMEAAAVWGAAQQANGRSLYGQGLEDLEAKAPPRPQGHEAETPGK 0
0 TKGLIPSQDPRM* 0

>MEL1_gorGor Gorilla gorilla (gorilla) Deut.Euth.Euar genomic full G? OPN4 melanopsin
0 MNPPSGPRVPPSPTQEPSCMATPAPPSWWDSSQSSISSLGRLPSISPT 0
0 APGTWAAAWVPLPTVDVPDHAHYTLGTVILLVGLTGMLGNLTVIYTFCR 2
1 SRSLRTPXNMFIINLAVSDFLMSFTQAPVFFTSSLYKQWLFGET 1
2 GCEFYAFCGALFGISSMITLXAIALDRYLVITRPLATFGVASKRRAAFVLLGVWLYALAWSLPPFFGW 1
2 SAyVPEGLLTSCSWDYMSFTPAVRAYTMLLCCFVFFLPLLIIIYCYIFIFRAIRETGR 2
1 ALQTFGACKGNGESLWQRQRLQSECKMAKIMLLVILLFVLSWAPYSAVALVAFAG 2
1 YAHVLTPYMSSVPaVIAKAsAIHNPIIYAITHPKYR 2
1 VAIAQHLPCLGVLLGVSRRHSRPYPSYRSTHRSTLISHTSNLSWISIRRRQESLGSESEV 0
0 GWTHMEAAAVWGAAQQANGRSLYGQGLEDLEAKAPPRPQGHEAETPGK 0
0 TKGLIPSQDPRM* 0

>MEL1_ponAbe Pongo abelii (orangutan) Deut.Euth.Euar genomic full G? OPN4 melanopsin
0 MNPPSGPRVPPSPTQEPSCMATPAPPSWWDSSQSSISSLGQLPSISPT 0
0 APGTWAAALVPFPTVDVPDHAHYTLGTVILLVGLTGMLGNLMVIYTFCR 2
1 SRGLRTPANMFIINLAVSDFLMSFTQAPVFFTSSLYKQWLFGET 1
2 GCEFYAFCGALFGISSMITLTAIALDRYLVITRPLATIGVASKRRAAFVLLGVWLYALAWSLPPFFGW 1
2 SAYVPEGLLTSCSWDYMSFTPAVRAYTMLLCCFVFFLPLLIIIYCYIFIFRAIRETGR 2
1 ALQTFGACKGNGESLWQRQRLQSECKMAKIMLLVILLFVLSWAPYSAVALVAFAG 2
1 YAHVLTPYMSSVPAVIAKASAIHNPIIYAITHPKYR 2
1 VAIAQHLPCLGVLLGVSRRHSRPYPSYRSTHRSTMISHTSNLSWISGRRRQESLGSESEV 0
0 GWTHMEAAAVWGAAQQANGRFLYDQGLEDLEAKAPPRPQGEEAETPGK 0
0 TKGLIPSQDPRM* 0

>MEL1_rheMac Rhesus macaca (rhesus) Deut.Euth.Euar genomic full G? OPN4 melanopsin fill-in traces
0 MNPPSGPRVPPSPTQEPSCMATPAPPSRWDSSQSSISSLGQLPSVSPT 0
0 AAGTWAAAWVPFPTVDVPDHAHYTLGTVILLVGLTGMLGNLTVIYTFCR 2
1 SRGLRTPANMFIINLAISDFLMSFTQAPVFFASSLYKHWLFGET 1
2 GCEFYAFCGALFGISSMITLTAIALDRYLVITRPLATIGVASKRRAAFVLLGVWLYALAWSLPPFFGW 1
2 SAYVPEGLLTSCSWDYMSFTPAVRAYTMLLCCFVFFLPLLIIIYCYIFIFRAIRETGr 2
1 ALQTFGACKGSGESLWQRQRLQSECKMAKIMLLVILLFVLSWAPYSAVALVAFAG 2
1 YAHVLTPYMSSVPAVIAKASAIHNPIIYAITHPKYR 2
1 VAIAQHLPCLGVLLGVSRRHSHPYPSYRSTHRSTLISHTSNLSWISGRRRQESLGSESEV 0
0 GWTHMEAAAVWGAAQQANGRSLYGQGLEDLEAKAPPRPQGQEAETPGK 0
0 TKGLLPCKDSRM* 0

>MEL1_calJac Callithrix jacchus (marmoset) Deut.Euth.Euar genomic full G? OPN4 melanopsin fill-in traces
0 MNLPTGSRVLPSPTQEPSCMTTPAPPSRWDSSQSSISSLSQLPSISPT 0
0 AAGTWAAAWIPFPTVDVPDHAHYTLGTVILLVGVTGMLGNLTVIYTFCR 2
1 SRGLRTPANMFIINLAVSDFLMSFTQAPVFFASSLYKRWLFGET 1
2 GCEFYAFCGALFGISSMITLMAIALDRYLVITRPLATIGVASTKRAAFVLLGVWLYALAWSLPPFFGW 1
2 SAYVPEGLLTSCSWDYMSFTPAVRAYTMLLCCFVFFLPLLIIIYCYIFIFRAIRETGR 2
1 ALQTFGACKGSGESLWQRQRLQSECKMAKIMLLVILLFVLSWAPYSAVALVAFAG 2
1 YAHVLTPYMSSVPAVIAKASAIHNPIIYAITHPKYR 2
1 VAIAQHLPCLGVLLGVSRRHSHPYPSYRSTHRSTLISHTSNLSWISGRRRQESLGSESEV 0
0 GWTHMEAAAAWGAAQQANGRSLYGHGLEDLEAKAPPRPQRQEAETPGK 0
0 tkGLLPSLDARW* 0

>MEL1_micMur Microcebus murinus (mouse_lemur) Deut.Euth.Euar genomic full G? OPN4 melanopsin fill-in traces 4aa del exon 9 confirmed
0 MNPPSGPRMPPSPAQEPSCVATPALASSGDSSQNSVSSLGQLLPASPT 0
0 ATGAWAAAWVPFPTADVPDHAHYTLGTVILLVGLTGMLGNLTVIYTFCr 2
1 SRSLRTPANMFVINLAVSDFLMSVTQAPVFFASSLYKRWLFGEA 1
2 gCEFYAFCGALFGISSMITLTAIALDRYLVITRPLASVGTASKRRAGLVLLGVWLYALAWSLPPFFGW 1
2 SAYVPEGLLTSCSWDYMTFTPSVRAYTMLLCCFVFFLPLLVIIYCYIFIFRAIRETGR 2
1 ALQTFGASKGTSESPRQQQRLQNEWKMAKIMLLVILLFLLSWAPYTAVALVAFAG 2
1 YAHILTPYMNSVPAVIAKASAIHNPIIYAITHPKYR 2
1 VAIAQHLPCVGVLLGVSRQHSRPYPSYRSTHRSTLSSQASDLSWISGRRRQESLGSENDM 0
0 GWTDMEVAAAWGAAPRVRGRCPYGQGPEDMEVKV QGQEAETPGK 0
0 AEGLPPCMDPRM* 0

>MEL1_otoGar Otolemur garnettii (lemur) Deut.Euth.Euar genomic full G? OPN4 melanopsin fill-in traces
0 mnLPSAPRVPPSPAQASSCVATPAPHSRWDSSQTSISSLGQLRPVSPT 0
0 ASGAWAAGWIPFPTVDVPDHAHYTLGTVILLVGLTGMLGNLTVIYTFCR 2
1 VRGLRTPANMFVINLAVSDFLMSVTQAPVFFASSLYKQWLFGET 1
2 GCEFYAFCGALFGISSMITLTAIALDRYLVITRPLTTVGVASKRRAALVLLGVWLYSLAWSLPPFFGW 1
2 SAYVPEGLLTSCSWDYTSFTPSVRTYTMLLCCFVFFLPLLIIIYCYIFIFRAIRETGR 2
1 ALQTFGACKGSSESPRQRQRLQNEWKMAKITLLVILFFVLSWAPYTTVALVAFAG 2
1 YAHVLTPYMNSVPAVIAKASAIHNPIIYAITHPKYR 2
1 VAIAQHLPCLGLLLGVSRQHSRPYPSYRFTHHSTLSSQASDLSWISGRRRQESLGSESEV 0
0 GWTDMEAAATWGAALQVSGQCPYSQGLEDMEAKGPLRPQGPETKTSGK 0
0 TKGLLPSLDPRM* 0

>MEL1_musMus Mus musculus (mouse) Deut.Euth.Euar AF147789 10632589 full G? OPN4 melanopsin GenBank wrong readthru
0 MDSPSGPRVLSSLTQDPSFTTSPALQGIWNGTQNVSVRAQLLSVSPT 0
0 TSAHQAAAWVPFPTVDVPDHAHYTLGTVILLVGLTGMLGNLTVIYTFCR 2
1 NRGLRTPANMFIINLAVSDFLMSVTQAPVFFASSLYKKWLFGET 1
2 GCEFYAFCGAVFGITSMITLTAIAMDRYLVITRPLATIGRGSKRRTALVLLGVWLYALAWSLPPFFGW 1
2 SAYVPEGLLTSCSWDYMTFTPQVRAYTMLLFCFVFFLPLLIIIFCYIFIFRAIRETGR 2
1 ACEGCGESPLRQRRQWQRLQSEWKMAKVALIVILLFVLSWAPYSTVALVAFAG 2
1 YSHILTPYMSSVPAVIAKASAIHNPIIYAITHPKYR 2
1 VAIAQHLPCLGVLLGVSGQRSHPSLSYRSTHRSTLSSQSSDLSWISGRKRQESLGSESEV 0
0 GWTDTETTAAWGAAQQASGQSFCSQNLEDGELKASSSPQVQRSKTPK 0
0 TKGHLPSLDLGM* 0

>MEL1_ratNor Rattus norvegicus (rat) Deut.Euth.Euar AY072689 11834834 full G? OPN4 melanopsin
0 MNSPSESRVPSSLTQDPSFTASPALLQGIWNSTQNISVRVQLLSVSPT 0
0 TPGLQAAAWVPFPTVDVPDHAHYTLGTVILLVGLTGMLGNLTVIYTFCR 2
1 NRGLRTPANMLIINLAVSDFLMSFTQAPVFFASSLYKKWLFGET 1
2 GCKFYAFCGAVFGIVSMITLTAIAMDRYLVITRPLATIGMRSKRRTALVLLGVWLYALAWSLPPFFGW 1
2 SAYVPEGLLTSCSWDYVTFTPLVRAYTMLLFCFVFFLPLLIIIFCYIFIFRAIRETGR 2
1 ACEGCGESPLRRRQWQRLQSEWKMAKVALIVILLFVLSWAPYSTVALVGFAG 2
1 YSHILTPYMSSVPAVIAKASAIHNPIIYAITHPKYR 2
1 AAIAQHLPCLGVLLGVSGQRSHPSLSYRSTHRSTLSSQSSDLSWISGQKRQESLGSESEV 0
0 GWTDTETTAAWGAAQQASGQSFCSHDLEDGEVKAPSSPQEQKSKTPK 0
0 TKRHLPSLDRRM* 0

>MEL1_nanEhr Nannospalax ehrenbergi (molerat) Deut.Euth.Euar AM748539 full G? OPN4 melanopsin
0 MNSPSGPRVPPGLAQKPSFMVTPVLPNQWISFQKNVSVGIQLPPASAT 0
0 ATGAQAASWVPFPTVDVPVHAHYTLGTVILLVGLTGMLGNLIVIYTFCR 2
1 SRGLRTRANMFTVNLAVSDFLMSFTQAPVFFASSLYKRWLFGEA 2
2 GCEFYAFCGAVSGITSMTTLTAIALDRYLVITRPLATIGVASKRRTALVLLGVWLYALAWSLPPFFGW 1
2 SAYVPEGLLTSCSWDYMTFTPSVRAYTMLLFCFVFFLPLLIIIFCYIFIFKAIRETGR 2
1 ACEGCGESPQRRRQWQRLQNEWKMAKVALLVIFLFVLSWAPYSTVALVAFAG 2
1 YSHILTPYMNSVPAVIAKASAIHNPIIYAITHPKYR 2
1 LAISQHLPCLGVLIGVSSQRSHPSLSYRSTHRSTLSSQASDLSWISGRKRQESLGSESEV 0
0 GWTDTEVTAAWGVAQEASGWSPYRHSLEDGEVKASPSPQGQEAKTSR 0
0 TKGQLPSLNLRM* 0

>MEL1_phoSun Phodopus sungorus (hamster) Deut.Euth.Euar AY726733 15698924 frag G? OPN4 melanopsin 3D ends in error: AKGQLPSLDLGMQDAP
0 MDSPPGPTAPPGLTQGPSFMASTTLHSHWNSTQKVSTRAQLLAVSPT 0
0 ASGPEAAAWVPFPTVDVPDHAHYILGTVILLVGLTGMLGNLTVIYTFCR 2
1 SRSLRTPANMLIINLAVSDFLMSFTQAPVFFASSLYKKWLFGET 2
1 GCEFYAFCGAVLGITSMITLTAIALDRYLVITRPLATIGMGSKRRTALVLLGIWLYALAWSLPPFFGW 1
2 SAYVPEGLLTSCSWDYVTFTPQVRAYTMLLFCFVFFLPLLVIIFCYISIFRAIRETGR 2
1 ACEGWSESPQRRRQWHRLQSEWKMAKVALIVILLFVLSWAPYSTVALVAFAG 2
1 YSHILTPYMSSVPAVIAKASAIHNPIVYAITHPKYR 2
1 AAIAQHLPCLGVLLGVSSQRNRPSLSYRSTHRSTLSSQSSDLSWISAPKRQESLGSESEV 0
0 GWTDTEATAVWGAAQPASGQSSCGQNLEDGMVKAPSSPQ
0 * 0

>MEL1_bosTau Bos taurus (cow) Deut.Euth.Laur genomic full G? OPN4 melanopsin
0 MNPPSGPRAPLGPVQESSCLATPASSSRWDSSRSSASSLGHPPSISPT 0
0 AVRAQAAAWVPFPTVDVPDHAHYTLGTVILLVGLTGMLGNLTVIYTFCR 2
1 SRGLRTPANMFIINLAVSDFLMSFTQAPVFFASSLYKQWLFGEA 1
2 GCEFYAFCGALFGITSMITLTAIALDRYLVITRPLATVGMVSKRRAALVLLGVWLYALAWSLPPFFGW 1
2 SAYVPEGLLTSCSWDYVSFTPSVRAYTMLLFCFVFFLPLLIIIYCYIFIFKAIRETGQ 2
1 ALQTFGTCEGGSECPRQRQRLQNEWKMAKIELLVILLFVLSWAPYSTVALMGFAG 2
1 YAHILTPYMNSVPAVIAKASAIYNPIIYAITHPKYR 2
1 LAIAQHLPCLGVLLGVSGQRTGLYTSYRSTHRSTLSSQASDLSWISGRRRQASLGSESEV 0
0 GWMDTEATAAWGAGQQVSGWSPCSQRLDDVEAKALPRPQGRDSEAPGK 0
0 AKGLLPNLDARM* 0

>MEL1_susScr Sus scrofa (pig) Deut.Euth.Laur genomic full G? OPN4 melanopsin
0 MNPPSRPSAPPDPALESSCMATPASPSRWDSSQSSTSSLGHPLPISPT 0
0 AARVRAAAWVPFPTVDVPDHAHYTLGTVILLVGLTGMLGNLTVIYTFCR 2
1 SRGLRTPANMFIINLAVSDFLMSFTQAPVFFASSLYKQWLFGEA 2
1 GCEFYAFCGAVFGITSMITLTAIALDRYLVITHPLATVGMVSKRRAALVLLGVWLYALAWSLPPFFGW 1
2 SAYVPEGLLTSCSWDYVSFTPKVRAYTMLLFCFVFLLPLLVIIYSYIFIFKAIRETGQ 2
1 ALQTFGACERRGKCPRQRQRLQNEWKMAKIELLVILLFVLSWAPYSTVALMGFAG 2
1 YGHVLTPYVNSVPAVIAKASAIYNPIIYAITHPKYR 2
1 MAIAQHLPCLGVLLGVSGQRTGLYTSYRSTHRSTLSSQASDLSWISGRRRQASLGSESEV 0
0 GWTDTEATAAWGAAQQVSRWSPCGQGLEDMEAKTSLGRLGWEAEAPGK 0
0 TKGLLPSLDPRM* 0

>MEL1_equCab Equus caballus (horse) Deut.Euth.Laur genomic full G? OPN4 melanopsin bad GenBank
0 MNPPSEPQVPLGLAQEPGCVATPASPSRWSGSRSSTSSLGQPLPVGPT 0
0 AAGAQADAWVPFPTVDVPDHAHYTMGTVILLVGLTGMLGNLTVIYTFCR 2
1 SRGLRTPANMFIINLAVSDFLMSFTQAPVFFASSLYKQWLFGKA 1
1 GCEFYAFCGALFGITSMITLTAIALDRYLVITRPLATVGVVSKRWAALVLLGIWLYALAWSLPPFFGW 1
2 SAYVPEGLLTSCSWDYMTFTPSVRAYTMLLMCFVFFLPLLVIVYCYVFIFRAIRETGR 2
1 ALQTFGAWEGGGECPRQRQRLQSEWKMAKIVLLVILLFVLSWAPYSVVALVAFAG 2
1 YAHVLTPYMNSVPAVIAKASAIHNPIIYAIIHPKYR 2
1 MAIAQHLPCLGVLLGVSSQRTRPYTSYRSTHRSTLSSQGSDLSWISGRRRQASLGSESEV 0
0 GWMDTEAAAVWGAAQQMSGWSPCGQGLEDMEAKAPPRPQGWEGEALRK 0
0 IKGLLPSLDPRM* 0

>MEL1_felCat Felis catus (cat) Deut.Euth.Laur AY382594 15842746 full G? OPN4 melanopsin wrong readthru
0 MNPPSGPRTQEPSCVATPASPSRWDGYRSSTSSLDQPLPISPT 0
0 AARAQAAAWIPFPTVDVPDHAHYTLGTVILLVGLTGILGNLMVIYTFCR 2
1 SRGLRTPANMFIINLAVSDFFMSFTQAPVFFASSLHKRWLFGEA 1
2 GCEFYAFCGALFGITSMITLMAIALDRYLVITHPLATIGVVSKRRAALVLLGVWLYALAWSLPPFFGW 1
2 SAYVPEGLLTSCSWDYMSFTPSVRAYTMLLFCFVFFLPLLVIVYCYIFIFRAIRETGQ 2
1 ALQTFRACEGGGRSPRQRQRLQREWKMAKIELLVILLFVLSWAPYSIVALMAFAG 2
1 YAHVLTPYMNSVPAVIAKASAIHNPIIYAITHPKYR 2
1 MAIAQHLPCLGVLLGVSGQHTGPYASYRSTHRSTLSSQASDLSWISGRRRQASLGSESEV 0
0 GWMDTEAAAVWGAAQQVSGRFPCSQGLEDREAKAPVRPQGREAETPGQ 0
0 TKGLLPSQDPRM* 0

>MEL1_canFam Canis familiaris (dog) Deut.Euth.Laur genomic full G? OPN4 melanopsin fixed 44-way
0 MNPPSGPGAQEPGCVATAASPGRWHGSPRSTVGLDQALPTGPT 0
0 AAGARAAAWAPFPTVDVPDHAHYILGTVILLVGLTGMLGNLMVIYTFCR 2
1 TRGLRTPSNMFIINLAVSDFFMSFTQAPVFFASSLHKRWLFGEA 1
2 GCEFYAFCGALFGITSMITLTAIALDRYLVITHPLAAVGVVSKRRAALVLLGVWLYALAWSLPPFFGW 1
2 SAYVPEGLLTSCSWDYMSFTPSVRAYTMLLFCFVFFLPLLVIVYCYVFIFRAIRETGQ 2
1 ALQTFRACEGGARSPRQRQRLQREWKMAKMELLVILLFVLSWAPYSAVALTAFAG 2
1 YSHVLTPYMNSVPAVIAKASAIHNPIIYAITHPKYR 2
1 MAIAQHLPCLGVLLGVSGQRTGPYASYRSTHRSTLSSQASDLSWISGRRRQASLGSESEV 0
0 GWMDTEAAAVWGAAQPAGGRFLCTQGLEDAEAKAPLRPRGQAVETPGK 0
0 TKGRLPSLDPSRE* 0

>MEL1_myoLuc Myotis lucifugus (microbat) Deut.Euth.Laur genomic full G? OPN4 melanopsin 7 aa del in exon 1 confirmed 1 aa del in DRY cyto loop
0 MNPPSGPRGPLDPAREPGCVATPVSP SSTSSVDPPLPTSPT 0
0 AAEAQAAAWVSFPTVDVPAHAHYTLGIVILLVGLTGMLGNLTVIYTFCR 2
1 SRGLRTPANMFIINLAVSDFLMCFTQAPVVFASSIYKRWLFGEA 1
2 GCEFYAFCGALFGITSMITLTAIALDRYLVITRPL AIGVVSKRRAALVLLGVWLYALAWSLPPFFGW 1
2 SAYVPEGLLTSCSWDYMSFTPAVRSYTMLLFCFVFFLPLLVIIYCYVFIFRAIRETGQ 2
1 ALQTFGACEGRSELPRQRQGLQNEWKMAKIVLLVILLFVLSWAPYSTVALMAFAG 2
1 YAHVLTPYMNSVPAIIAKASAIHNPIIYAITHPKYR 2
1 MAIAQHLPCLGLLLGVSGQRTGPYASYRSTHRSTLSSQASDLSWVSRRRRQESLGSESEM 0
0 GWTDTEAAAMWGAAQQVSGPPPCSQGLEDVETKAPPKSQGHEAEDPRK 0
0 TKGLLPSPDPRM* 0

>MEL1_pteVam Pteropus vampyrus (macrobat) Deut.Euth.Laur genomic full G? OPN4 melanopsin
0 MNLPVGPRVPLDPAQEPSCMATPASPS WDSSPSSASSLDQPLPISPT 0
0 AAGSQAAAWVPFPTVDVPDHAHYTLGTVILLVGLTGMLGNLTVIYTFCR 2
1 SRGLRTPANMFIINLAVSDFLMSFTQAPVVFISSLYKRWLFGQA 1
2 GCEFYAFCGALFGITSMITLTAIALDRYLVITRPLAAIGVVSKRRAALVLLGVWLYALAWSLPPFFGW 1
2 SAYVPEGLLTSCSWDYMSFTPSVRAYTMLLFCFVFFLPLLIIIYCYIFIFRAIRETGQ 2
1 ALQTFGACEGLSELPRQRQRLQSEWKMAKIVLLVILLFVLSWAPYSTVALMAFAG 2
1 YSHVLTPYMNSVPAIIAKASAIHNPIIYAITHPKYR 2
1 MAIAQHLPCLGVLLGMSGQHTGPYTSYRSTHRSTLSSQASDLSWISRRRRQASLGSESEM 0
0 GWTDTEAAATWGTAQQVSGPSLWGQDLEDVEAKAPPKPQGREAEAPRK 0
0 TKELLPSLDPRM* 0

>MEL1_eriEur Erinaceus europaeus (hedgehog) Deut.Euth.Laur genomic full G? OPN4 melanopsin
0 MALSLGPRVPTSQALDPSCMDTPASPSRWDSSQNSTSSLAQLPLISLT 0
0 SVSPQATASAPFPTVNVPDHAHYTLGTVILLVGLTGMLGNLTVIYTFCR 2
1 SRSLRTPANMFIINLAVSDFLMSFTQTPVFFASSLYKQWLFGEA 1
2 GCEFYAFCGALFGITSMITLTAIALDRYLVITRPLATIGVVSKRRVALVLLGVWLYSLAWSLPPFFGW 1
2 SAYVPEGLLTSCSWDYMRFTPSFRAYTMLLFCFVFFLPLLVIIYCYIFIFRAIRETGQ 2
1 ALQTFRACEGSCDFPRQQQRLQSEWKMAKIILLVILLFVLSWAPYSTVALMAFAG 2
1 YAHVLTPYMNSVPAVIAKASAIHNPIIYAITHPKYR 2
1 MAIAQHLPCLRVLLGVSGQRDRPYTSYRSTHRSTLSSQISDLSWVSRRRRQASLGSESEV 0
0 GWTDTEVAAVWGT MSGHFPCGQGLDDMEAKAAHNPRGLEAETPGK 0
0 IKGLLPSLDPQM* 0

>MEL1_loxAfr Loxodonta africana (elephant) Deut.Euth.Afro genomic frag G? OPN4 melanopsin
0 MNPPWGPRVPSGRAQEPSCVATPASASRWNSSRASASSLGELPPSSPT 0
0 AARAHTAAWDPFPTVDVPDHAHYTLGAVILLVGLMGMLGNLMVIYIFFR 2
1 SRGLRTPANMFIINLAVSDFLMSFTQAPVFFASSLYKRWLFGEA 1
2 GCKFYAFCGALFGITSMITLTAIALDRYLVITRPLATIGVVSKRRAALVLLGIWLYALAWSLPPFFGW 1
2 SAYVPDGLLTSC 2
1 ALQTFGACEGASEPPRQWQRLQSEWKMAKIALLAILLYVLSWAPYSTVALVAFAG 2
1 YAHVLTPYMNSVPAVIAKASAIHNPIIYAITHPKYR 2
1 MAIAQHLPCLGVMLGVSGQRTRPYTSYHSTLHSTLSSQASDLSWISGRRRQASLGSESEV 0
0 GWTDTEAAAAWEGAQQVSGQASCSQALQNLEANTPPRPQGWGPETPRK 0
0 * 0

>MEL1_proCap Procavia capensis (rock_hyrax) Deut.Euth.Afro genomic full G? OPN4 melanopsin
0 MNPPWGPRVPSRPAQEPSCMSTPASAGRWDSSQATASSLAELPPSSPT 0
0 EARTQTADWVPFPTVDVPDYAHYTLGTVILLVGLTGVLGNLMVIYIFFR 2
1 SRGLRTPANMFIINLAISDFLMSLTQAPVFFASSLYKRWLFGEA 1
2 GCEFYAFCGALFGITSMITLTAIALDRYLVITRPLATIGVVSKRRTALVLLGTWLYALAWSLPPFFGW 1
2 SAYVPDGLLTSCSWDYKSFMPSARTYTMLLCCFVFFLPLLVIIYCYVFIFKAIRETGR 2
1 ALQTFGACEGASETPRQWQRLQSEWKMAKIALLAILLYVLSWAPYSTVALVGFAG 2
1 YAHVLTPYMNSVPAVIAKASAIHNPIIYAITHPKYR 2
1 MAIAQHLPCLGVLLGVSDQHTRPYTSYRSTHHSTLSSQASDISWISGRRRQASLGSESEV 0
0 GWTDTEAAAAWEGAQQVSGRASCSQVLESMEANTPPRPQGWGPETPRK 0
0 VKGLPLLDPRA* 0

>MEL1_echTel Echinops telfairi (hedgehog) Deut.Euth.Laur genomic frag G? OPN4 melanopsin
0 MNLPSGSRVPSGPAQEPSHVATAASASRWNS GSSLDAPPPSSPT 0
0 AARAPTAASAPFPIVDVPDHVHYTLGTVILLVGLTGMLGNLMVIYTFCR 2
1 SRSLRTPANMLIINLAVSDFLMSFTQAPVFFTSSLYKQWLFGEA 1
2 GCEFYAFCGALFGITSMITLTAIALDRYLVITRPLATIGVVSKRRAALVLLVIWLYALAWSLPPFFGW 1
2 SAYVPDGLLTSCSWDYMSFTPSVRAYTMLLFCFVFFLPLLVIIYCYIFIFRAIRETGR 2
1 ALQTFGACEGSRDSPRQRQRLQSEWKMAKIALLVISLFVLSWAPYSTVVLVAFAG 2
1 2
1 0
0 GWTDTEVTATSGYTQQVSGRCPRGQDLESMDANPTPRPRGWETETAQK 0
0 IKGLPLSLNPQA* 0

>MEL1_monDom Monodelphis domestica (opossum) Deut.Meta.Dide genomic full Gq OPN4 melanopsin syn(-GRID1 -WAPAL +LDB3 +BMPR1A)
0 MNPSPMLRGLSCPAQDTNCTKIMASMSEWNNTEEDAYHLVDLPSIAPT 0
0 AVVLPPSSQNIFPTVDVPDHAHYTIGAIILAVGITGMLGNFLVIYTFCR 2
1 SHSLRTPANMFIINLAISDFFMSFTQAPVFFASSMYKRWIFGEK 1
2 ACEFYAFCGALFGITSMITLMAIALDRYFVITRPLASIGVISKKKTGFILLGVWLYSLAWSLPPFFGW 1
2 SAYVPEGLLTSCSWDYTTFTPSVRAYTMLLFCFVFFIPLIVIIYCYIFIFRAIQDTNK 2
1 AVHSIGSGESTASPRHCQRMKNEWKMAKIALVVILLYVLSWAPYSTVALVAFAG 2
1 YSHILTPYMNSVPAIIAKASAIHNPIIYAISHPKYR 2
1 MAIAQNFPCLRALLCVRHPRTRSFSSYRFTRRSTMTSQASDISWLPRGRRQLSLGSESEI 0
0 GWNNMEAGTTSLTSRNQQGSCRMDQETMETRELAAIAKAKGRSWETLEK 0
0 TLEEMDDSSLLEVSVDMEQ* 0

>MEL1_smiCra Sminthopsis crassicaudata (dunnart) Deut.Meta.Dasy DQ383281 17785267 full G? OPN4 melanopsin
0 MNPSPMLRHLSCPAQDSNCTKIMASISEWNNTEVDAYHLVDLPPITPT 0
0 AVVLPPYSQKVFPTADVPDYAHYTIGATILVVGFTGVLGNLLVIYTFCR 2
1 SRSLRTPANMFIINLAISDFFMSFTQAPVFFASSLYERWIFGEK 2
1 GCEFYAFCGALFGITSMITLMVIALDRYFVITRPLASIGMISKKKTGLILLGVWLYSLAWSLPPFFGW 1
2 SAYVPEGLLTSCSWDYTTFTPSVRAYTILLFCFVFFIPLTVIIYCYIFIFRAIKDTNK 2
1 AVQNIGSSEHTPSLRHFQRMKNEWKMAKIALVVILLFVLSWAPYSTVALVAFAG 2
1 YSHVLTPYMNSVPAIIAKASAIHNPIIYAISHPKYR 2
1 MAIAQNFPCLRAVLGIRHPRTQSFSSYRFTHRSTTASQASDISWQSRGRRQLSLGSESEA 0
0 GWNNIETGLTLRSLEGSCGMDEETMDTRELSASTKAKGQSWETLAKTLEE 0
0 MDDLSLLEAGTLLSSLDLQI* 0

>MEL1_ornAna Ornithorhynchus anatinus (platypus) Deut.Prot.Mono genomic frag Gq OPN4 melanopsin
0 0
0 FPTADVPDHAHYTIGATILAVGFTGVLGNLLVIYTFCR 2
1 SRSLRTPANMFIINLSISDFFMSLTQAPVFFASSLHKRWIFGEK 1
2 GCQLYAFCGALFGITSMITLTVIALDRYFVITRPLASIGVISKKRALLILTGVWFYSLAWSLPPFFGW 1
2 sAYVPEGLLTSCSWDYMTFTPPVRAYTMLLFCFVFFIPLIMIIYCYFFIFRAIRGTNK 2
1 AVETIGSDDCRGSQRQCQRMKNEWKTAKIALMVILLYVISWCPYSVVALVAFAG
1 YSHLLTPYMNSVPAVIAKSSAIHNPIIYAITHPKYR 2
1 MAITKYIPCLGPLLRVSRQDSRSSSHYASSRRSTVTSQSLDGSWLPGRRRPLSSASDSES 0
0 0
0 * 0

>MEL1_anoCar Anolis carolinensis (lizard) Deut.Saur.Lepi genomic frag G? OPN4 melanopsin diverged
0 0
0 ERTMFNLPDPFPTVDVPTHAHYTIGAVILVVGITGTLGNLLVIYVFFR 2
1 IRGLRTPANMFVINLAVSDFL 1
2 GCELYAFCGALFGIASMITLTVIALDRYFVITRPLASIGAMSTKKALLILSGVWLYSLAWSLPPFFGW 1
2 sAYVPEGLLTSCSWDYITFTPSVRAYTMLLFCFVFFIPLIAIIYSYVFIFIAIKNSNR 2
1 AVQRTNSDNSKEGQKLYQKLKNEWKMAKVALIVILLVISWSPYSVVALVAFAG 2
1 YSHLLTPYMNSVPAVIAKASVIHNPIIYAIVHPKYR 2
1 MAIAKFLPCLGSLLRVPRKDSSYPSTRRPTVTSQSSDINGVPRGHRRLSSVSDSES 0
0 DWTDTEADISSQNSRVASGSISYRIYEDTTETIKVKSKMRSHDSGIFER 0
0 0
0 TGEDLNAFGWRREESYSGPSTSSQIPSIIVTFSNVQRTDLPLESSSGALCSRNSSYSWEKDSNS* 0

>MEL1_galGal Gallus gallus (chicken) Deut.Saur.Arch AY88294 16856781 full Gq OPN4 melanopsin syn(-GRID1 -WAPAL +LDB3 +BMPR1A) short exon 1
0 MDLPPRAPT 0
0 KMTVKDVRGAFPTVDVPDHAHYTIGTVILIVGITGTLGNFLVIYAFCR 2
1 SRTLQKPANIFIINLAVSDFLMSITQSPVFFTNSLHKRWIFGEK 1
2 GCELYAFCGALFGITSMITLMVIALDRYFVITKPLASVRVMSKKKALIILVGVWLYSLAWSLPPFFGW 1
2 SAYVPEGLLTSCSWDYMTFTPSVRAYTMLLFCFVFFIPLIAIIYSYVFIFEAIKKANK 2
1 SVQTFGCKHGNRELQKQYHRMKNEWKLAKIALIVILLYVISWSPYSVVALVAFAG 2
1 YSHVLTPFMNSVPAVIAKASAIHNPIIYAITHPKYR 2
1 TAIATYVPCLGFLLRVSPKESRSFSSYPSSRRTTITSQSSETSGLQKGKRRLSSISDSES 0
0 GCTDTETDITSMISRPASSQVSYEMGEDTTQTSDLGGKPKVKSHDSGIFRK 0
0 TVVDADEIPMVEINDTEHSATSTCKTSEKCNVEEIQ 0
0 RSESLSGIGLREGESRHRTSASQIPSIIITYSNVQGVELHSGYSAGFLHPKNKSHKQNKSSNS* 0

>MEL1_taeGut Taeniopygia guttata (finch) Deut.Saur.Arch genomic full G? OPN4 melanopsin short exon 1 -GRID1 +LDB3 synteny
0 MDLLLRAPT 0
0 KMTVQDVPRAFPTVDVPDHAHYTIGVVILIVGITGTLGNFLVFYAFCR 2
1 SRSLQTPANILIINLAISDFLMSITQSPVFFTSSLYKHWIFGEK 1
2 GCELYAFCGALFGITSMITLMVIALDRYFVITKPLASVGVTSKKKALIILVGVWLYSLAWSLPPFFGW 1
2 sAYVPEGLLTSCSWDYMTFTPSVRAYTMLLFCFVFFIPLIAIIYSYVSIFEAIKKANK 2
1 SIQTFGCKRGNREFQKQYQRMKNEWKMAKIALIVILFFVISWSPYSVVALVAFAG 2
1 YSHVLTPFMNSIPAVIAKASVIHNPIIYAITHPKYR 2
1 KAIATYVPCLGPLLRVSPKDSRSFSSYHSSRRATISSQSSEISGLQERKRRLSSLSDSES 0
0 GCTETETDTPSMFSRLARRQISYKTDKDTTQTSDIRAKLTSQDSGNCGK 0
0 TAVDADDILMVELNVTEYMATPTVRTILLIFGNKN 0
0 KSESLNSIGQRREFHQGSSSAQIPSITITCSSVQGIELPSRYNSGFLYPKSSSHKQNKKSSS* 0

>MEL1_xenTro Xenopus tropicalis (frog) Deut.Amph.Anur DQ384639 16856781 full Gq OPN4 melanopsin syn(-GRID1 -WAPAL +LDB3 +BMPR1A)
0 MNYQSVRKGITCPPQDANCSRILESLNSWNNSEVNSYKLVELPPIVTT 0
0 ETPQYEIHHVYPTVDVPDHVHYVVGAVILAVGITGMLGNFLVIYAFCR 2
1 SRSLRSPANMFIINLAITDFLMSVTQAPVFFATSLHKRWIFGEK 1
2 GCELYAFCGALFGITSMITLMVIAVDRYFVITRPLTSIGVMSKKRAVLILSGVWLYSLAWSLPPFFGW 1
2 SAYVPEGLLTSCTWDYMTFTPSVRAYTMLLFCFVFFIPLFIIIYCYIFIFKAIKNTNR 2
1 AVQKIGTDNNKESHKQYQKMKNEWKMAKIALIVILLYVVSWSPYSTVALLAFAG 2
1 YASILTPYMNSVPAVIAKASAIHNPIIYAITHPKYR 2
1 MAIAKYIPCLGSLLRVKRRDSRSYSSYPSSRRSTVTSHCSQSSDVGGHPKLKNHLPSVSDSES 0
0 GWTDTEADSSVNSRPASRQVSYEMGKDTTETNDLKSKAKLKSHDSGIFEK 0
0 TSMDADDISLVELGTVDRSSPIM 0
0 ANKHLNGLGQRKGDSFTRRSPSSRIPSIVVTHSNHQGSPAAVRHNSTLPGIKVSNSQDREKELKRQIEKVKQYVPIVTITSDTENSTGGFSNELLPANTS* 0

>MEL1a_danRer Danio rerio (zebrafish) Deut.Acti.Otoc AY078161 12487121 full Gq OPN4 melanopsin syn(- +USP54 +LDB3 +BMPR1A)
0 MMSGAAHSVRKGISCPTQDPNCTRIVESLSAWNDSVMSAYRLVDLPPTTTTTTSVA 0
0 MVEESVYPFPTVDVPDHAHYTIGAVILTVGITGMLGNFLVIYAFSR 2
1 SRTLRTPANLFIINLAITDFLMCATQAPIFFTTSMHKRWIFGEK 1
2 GCELYAFCGALFGICSMITLMVIAVDRYFVITRPLASIGVLSQKRALLILLVAWVYSLGWSLPPFFGW 1
2 SAYVPEGLLTSCTWDYMTFTPSVRAYTMLLFIFVFFIPLIVIIYCYFFIFRSIRTTNE 2
1 AVGKINGDNKRDSMKRFQRLKNEWKMAKIALIVILMYVISWSPYSTVALTAFAG 2
1 YSDFLTPYMNSVPAVIAKASAIHNPIIYAITHPKYR 2
1 LAIAKYIPCLRLLLCVPKRDLHSFHSSLMSTRRSTVTSQSSDMSGRFRRTSTGKSRLSSASDSES 0
0 GWTDTEADLSSMSSRPASRQVSCDISKDTAEMPDFKPCNSSSFKSKLKSHDSGIFEK 0
0 SSSDVDDVSVAGIIQPDRTLTN 0
0 AGDITDVPISRGAIGRIPSIVITSESSSLLPSVRPTYRISRSNVSTVGTNPARRDSRGGVQQGAAHLSNAAETPESGHIDNHRPQYL* 0

>MEL1b_danRer Danio rerio (zebrafish) Deut.Acti.Otoc genomic frag Gq OPN4 melanopsin syn(- +USP54 +LDB3 +BMPR1A)
0 QVAMVQDVRHPFPTVDVPDHAHYTIGSVILAVGITGMVGNLLVMYAFCK 2
1 SRSLRTPANMFIINLAVTDFLMCVTQTPIFFTTSLHKRWIFGEK 1
2 GCELYAFCGALFGICSMITLMIIAVDRYFVITRPLASIGVMSRKRALLILSAAWAYSMGWSLPPFFGW 1
2 SGAYVPEGLLTSCSWDYMTFSPSVRAYTMLLFTFVFFIPLFVIIYCYFFIFKAIRETNR 2
1 AVGKINGEGGPRDSIKKIHRMKNEWKMAKIALIVILLYVISWSPYSCVALTAF 2
1 YADMLTPYMNSVPAVIAKASAIHNPIIYAITHPKYR 2
1 SAIAKYIPCLGVLLCVPRRDRFSSSSFISTRRSTLTSQSSETSSNLHRAGKARLSSVSDSES 0
0 GWTDTEADLSTASSRPASRQVSSEIRKDLCDIKHSSSLRLKVKSRDSGIFDR 0
0 0
0 QNDVSEKADEKRPLVRIPSIIVTSETCPAVLPAGHSSRLIPGAPAVTDS* 0

>MEL1_tetNig Tetraodon nigroviridis (pufferfish) Deut.Acti.Perc genomic full G? OPN4 melanopsin first exon uncertain
0 MGEVGVTVGPACSAAAAYQSGVSCGGELEPSGSAVVMTSLRLAELQLPAST 0
0 LQVAMARPFPTVDVPDHAHYTIGSVILAIGITGMIGNFLVIYAFCR 2
1 SRSLRTPANIFIINLAVADLLMCVTQTPIFFTTSMHKRWIFGEK 1
2 GCELYAFCGALFGICSMITLTVIAIDRYFVITRPLTSIGVLSRKRAFIILMTVWVYSLGWSLPPFFGW 1
2 SAYVPEGLLTSCTWDYMTFTPSVRAYTMLLFIFVFFLPLFIIIFCYIFIFRAIRSTNK 2
1 AVGKVNGSVHSHSRRQESLKKLQRLQSEWRMAKVALIVILLYVISWSPYSCVALTAFAG 2
1 YADMLTPYMNSVPAVIAKASAIHNPIIYAITHPKYR 2
1 LALARYIPCLGLLLCVSPQELRSTSSSFMSMRRSTVTSQTSDISGQFRRQSKPRLSTASDSES 0
0 CLTDTEADLTSTASRPASRQVSCDIGRDTADLPEFQPAASFKSKAKSPDSGVFEK 0
0 TSFDFDASMAAPRQHSSIPN 0
0 NGDFSEGHVTRVALGRIPSIVITSESSFLPHGRKGSASTSAQTATSSDGKAGLG* 0

>MEL1_takRub Takifugu rubripes (fugu) Deut.Acti.Perc genomic full Gq OPN4 melanopsin syn(- +USP54 +LDB3 +BMPR1A)
0 MNFGKSALQPPAQQSVVSCGGGGPEPNCTLRLAVTVMMSVRLAELQLHAST 0
0 LQVAMVRPFPTVDVPDHAHYTIGSVILVIGITGMIGNFLVIYAFCR 2
1 SRSLRTPANMFIINLAVTDLLMCVTQTPIFFTTSMYKRWIFGEK 1
2 GCELYAFCGALFGICSMITLTVIAIDRYFVITRPLTSIGVLSRKRAFVILMTVWIYSLGWSLPPFFGW 1
2 SAYVPEGLLTSCTWDYMTFSPSVRAYTMLLFIFVFFLPLFIIIYCYFFIFRAIRATNK 2
1 AVGKVNGSVHSHSRRRESVKNFQRLQNEWKMAKIALMVILLYVISWSPYSCVALTAFAG 2
1 YADMLTPYMNSVPAVIAKASAIHNPIIYAITHPKYR 2
1 LALAKYIPCLGFLLCISPHELQSTSSSFMSLRRSTVTSQTSDISGQFRPQSKPRRSSASDSES 0
0 CLTDTEADLSSMGSRPASRQVSCDISRDTTELPEYKPASSFNSKVKSPDSGIFEK 0
0 TSFDFDASMAASRERSSIPN 0
0 SGEFPEGHVMRRTLARIPSIIITSESSHFLPNGRKASSTTCIANGSDIKVGPR* 0

>MEL1_gasAcu Gasterosteus aculeatus (stickleback) Deut.Acti.Perc genomic full Gq OPN4 melanopsin syn(- - +LDB3 +BMPR1A)
0 MNAGESELLLPTQQSILPCGDHEPNCPVAQAETLALSAASANGSA 0
0 VQVAMVSRAPHPYPTVDVPDHAHYTIGSVILAIGITGIIGNVLVIYAFSK 2
1 SRSLRTPANMFIINLAITDLLMCVTQAPIFFTTSMHKRWIFGEK 1
2 GCELYAFCGALFGICSMITLTVIALDRYFVITRPLTSIGMMSRRRALLILMGAWTYSLGWSLPPFFGW 1
2 SAYVPEGLLTSCTWDYMTFTPSVRAYTMLLFIFVFFLPLFIIIYCYFFIFRAIRVTNR 2
1 AVGKMNGSIHSHGSGRDSTKNFHRLQNEWKMAKIALIVILLYVVSWSPYSAVALTAFAG 2
1 YADMLTPYMNSVPAVIAKASAIHNPIIYAITHPKYR 2
1 IALAKYIPFLGVLLCVPPRELRSASSSFRSTRRSTVTSQTSDVSSQQRRQGSRNSRLSSASDSES 0
0 CLTDTEADGSSVGSRPASRQVSCDIGRDTAELPEFKPSSSFKSKMKSHDSGIFEK 0
0 SYDTDISMAGVSERGSIPN 0
0 QTDFAEGRDRRSTIGRIPSIVITSETSPFLPTGRNGSCNGRPKTANSSHPGAGSG* 0

>MEL1_oryLat Oryzias latipes (medaka) Deut.Acti.Perc genomic full Gq OPN4 melanopsin syn(- +USP54 +LDB3 +BMPR1A)
0 LQVAMVPQTFHPFPTVDVPDHAHYTIGSVILAIGITGIIGNFLVIYAFSR 2
1 SRSLRTPANMFIINLAITDLLMCVTQSPIFFTTSMHKRWIFGEK 1
2 GCELYAFCGALFGICSMITLTVIAIDRYFVITRPLTSIGVLSRKRALLILSAAWAYSLGWSLPPFFGW 1
2 SAYVPEGLLTSCTWDYMTFTPSVRAYTMLLFIFVFFLPLFIIIYCYVFIFRAIRSTNR 2
1 AVGKINGNTRDAVKSFNRLQNEWKMAKIALIVILLYVISWSPYSTVALTAFAG 2
1 YADMLTPYMNSIPAVIAKASAIHNPIIYAITHPKYR 2
1 MALAKYIPGLGVLLCIHPKDLRSASSSFVSTRRSTVTSQSSDISSQLRRQSTFKSRLSSLSDSES 0
0 GLTDTEADLSSLSSRPASRQVSCEISRDTAELPDFKHTSSFKAKLKNNDSGIFEK 0
0 TSFDTVSIGGVSEHNSIPS 0
0 NRDFGDGNVTRATIGRIPSIVVTSEMSPFLPVGRNGSRTNRSKMANSSAGAGPV* 0

>MEL1a_calMil Callorhinchus milii (elephantfish) Deut.Chon.Holo genomic frag Gq OPN4 melanopsin
0 ASVTDAQHHHMFPTVDVPDHAHYIIGATILAVGVTGMVGNFLVIYAFLR 2
1 SRSLRTPANTFIINLAATDFLMSVTQSPIFFITSIHKRWIFGEK 1
2 GCELYAFCGALFGITSMITLMVIALDRYFVITRPLASIGVLSHRRAGLIILSLWLYSLAWSLPPFFGW 1
2 SAYVPEGLLTSCTWDYMTFTPSVRAYTMLLFCFVFFIPLGVIIYCYIFIFRAIKSTNK 2
1 KVGGSTNRESQKQHQRMKNEWKMAKIALIVILLFVISWSPYSTVALTAFAG 2
1 YADMLTPYMNSVPAVIAKASAIHNPIIYAITHPKYR 2
1 MAIAKYVPLLGLLLRVSRRDSRTSGQYYSTRRSTLTSQTSDLSGYPRGKGRLSSASDSES 0

>MEL1b_calMil Callorhinchus milii (elephantfish) Deut.Chon.Holo genomic frag Gq OPN4 melanopsin based on Squalus
1 SKSLRTPANMFIINLAISDFFMSATQPPVFFVTSLHKRWIFGEK
2 GCKLYAFCGALFGITSMITLMAISIDRYWVITKPLQSISSTTTKKNTLKVIILVWLYSLAWSLPPLLGW 1

>MEL1_petMar Petromyzon marinus (lamprey) Deut.Agna.Hype genomic frag G? OPN4 melanopsin first exon uncertain
0 MAPSIVPLMRKLSCPLSRKTPPKHNVSTSMFDGGDGVLGVIGSIP 0
0 VSFLPSQREKFPMLDIPHHVHHTIGSVVIAIGFTGIIGNFLVIYVFCR 2
0 VQVAMVSRAPHPYPTVDVPDHAHYTIGSVILAIGITGIIGNVLVIYAFSK 2
1 SKSLRSPANIFIINLAFADFFMSITQTPIFFVTSLHKRWIFGEK 1
2 GCELYAFCGALFGIASMVTLMVIATDRYLVLTRPLASIGAMSKRRAMYITAAVWFYSLAWSLPPFFGW 1
2 SAYVPEGLMTSCTWDYVTFTPAVRSYTMLLFCFVFFIPLIVIIFCYVRIFAAIKNTNR 2
1 AVKTLGDAHDSKESQKQQQRMNAEWKLAKIALIVILLYVVSWSPYSCVALVAWAG 2
1 YADMLTPYMNSVPAIIAKASAIHNPIVYAITHPKYR 2

>MEL1_cioInt Ciona intestinalis (tunicate) Deut.Uroc.Tuni AABS01000008 frag G? OPN4 melanopsin transcripts BW447434 BW019524 BW048729 rough seq
0 DRRYPSCYKGEQVTFIYLIPIFLFRTLAFLSSVFVTMTPSAVLPLVTTEARPVHPINDVAMYTFGGLMLTAGTVAVVGNIMVMYTFLRR 0
1 PLHWFIVQLAVADFFVGLIVLWIGTFSSLFLDTVSLMSGIATYGVLAAATSTSTLGVLFIAVDRHFYILRHRRYKQIMTRLRVGTAIVVACVVPATFFVVVPAFGWN 1
2 PEYIEEPLIPSCIFDRFTNSLSNRLYIITMCTFVFFIPLVFICYCLYRIFWAVKSSS 0
2 SLSRAGSRKSQSSGKLSKSNSSRSKRGIQTIEFQILKSAVLLVVLFVSSWMPFTVAAIISIGSNQVSPYVILVSYLFAKASCVHSSFAYITNAHFRATIGLIRCKHTHRA* 0

>MEL1_cioSav Ciona savignyi (tunicate) Deut.Uroc.Tuni AABS01000008 frag G? OPN4 melanopsin 0 transcripts rough
FTTLATLAVIPPTMVLNNSTHPIKVSALLAFGSLMLCAGIIAIVGNLVVMYTFLRPLNWFILQLAVADFFVGLIVLWIGVFSSLLL
ETVSLMSGVATYGVLAAATSTSTLGVLFIAVDRHFYILKHRRYKSIMTRVKVGVAIFFACVTPLAFFVAAPAAGWN 1
DYIAEPLIPSCIFDRFTTSLANQTYIITMCAFVFFVPLLFICYCLVRIYKAVKTSSQTVEFQILKSAVLLMVLFVS
SWMPFTVAAMISVVAEQVDPYVILVSYLFAKASCVHSSFAYITNAHFRATLGVLRCKKRRSV* 0

>MELx_braFlo Branchiostoma floridae (amphioxus) Deut.Ceph.Bran XP_002586120 full Gq
0 MDRMSPNLTNTSLLPNRTDRPELTPADVTMQLVFGSMMLVFGLIGVVGNAVALYAFCS 2
1 TRKLRRPKNYVVANLCLTDLIMCIVYCPVIVISSFSGR 2
1 IPTDGACTMEGFVVGMASIASVGSL 0
0 VAIAVERFFSITRPMKSLTILTKRTFLGGVAVVWLYSLILVIPPLLGWGRYVREETKLSCSFDYLSTDDANRSYVIWLVIVAFGLPLLVIAYCYISVFITVKKCTKKRKLMSPHKKSRSEVKTAVNAFIMTTAFCLCWCPY
AVVATMGISGSSVQGTVVFGAALLAKLSVLINPVAYVFSIPSFRKALFGHRKRGYGTSDGLANDSSSEKRRGKKHESDANSATEYLRLTVFYSMYSRTGQLSPWASKRLAGKTKSMLDLTTEYGRLERTAHKESWV* 0

>MEL_braFlo Branchiostoma floridae (amphioxus) Deut.Ceph.Bran AB205400 15936279 full Gq Amphi-mop 12 exons
0 MTELPSFQPPTNSTEEENAVFPTALTEWISE 0
0 VGNQVGEAALKLLSGEGDGMEVTPTPGCTGNASVCNGTDSGGGVVWDIPPLAHYIVGTAVFCVGCCGMFGNAVVVYSFIK 2
1 SKGLRTPANFFIINLALSDFLMNLTNMPIFAVNSAFQRWLLSDF 1
2 ACELYGFAGGLFGCLSINTLMAISMDRYLVITKPFLVMRIVTKQR 0
0 VMFAILLLWIWSLVWALPPLFGWSAYVPEGF 1
2 GTSCTFDYMTPKLSYHIFTYIIFFTMYFIPMGVIIYCYYNIFATVKSGDKQFGKAVKEMAHEDVKNK 0
0 AQQERQRKNEIKTAKIAFIVITLFLSAWTPYAVVSALGTLGYQDLVTPYLQSIPAVFAKSSAVYNPI 1
2 VYAITHPKFRAAVKKHIPCLSGCLPADEEETKTKTRGATTTASMSMTQTTAPTV 0
0 HDPQASVHSGSSVSVDDSSGVSRQDTMMVK 0
0 VEVDNRMEKAGGGAADTAPKDGTSVPTVSAQIEVRPSGNVNTKAEVIPSPQSAAVAHGASASPVPK 0
0 VAELSSSVSLESAAIPGKIPTPLPSQPIAAPIERHMAAMADDPPPKPRGVATTVNVRRSESGYERSQDSLRKK 0
0 AVSETRSRSFNSTKDHFASERQTSTTLNQPRDMYSGDMVKKTRQSPEKQEYDNPAFDAGIAEIDTDSENETEGSYDMLSVRFQAMAEEPPVETYRKASDMSINLGKASLMLTEAHDETVL* 0

>MEL_braBel Branchiostoma belcheri (amphioxus) Deut.Ceph.Bran AB205400 15936279 full Gq Amphiop6
0 MTEIPSFQPPINATEVEEENAVFPTALTEWFSE 0
0 VGNQVGEVALKLLSGEGDGMEVTPTPGCTGNGSVCNGTDSGGVVWDIPPLAHYIVGTAVFCIGCCGMFGNAVVVYSFIK 2
1 SKGLRTPANFFIINLALSDFLMNLTNMPIFAVNSAFQRWLLSDF 1
2 ACELYGFAGGLFGCLSINTLMAISMDRYLVITKPFLVMRIVTKQR 0
0 VMFAILLLWIWSLVWALPPLFGWSAYVSEGF 1
2 GTSCTFDYMTPKLSYHIFTYIIFFTMYFIPGGVMIYCYYNIFATVKSGDKQFGKAVKEMAHEDVKNK 0
0 AQQERQRKNEIKTAKIAFIVISLFMSAWTPYAVVSALGTLGYQDLVTPYLQSIPAMFAKSSAVYSPI 1
2 VYAITYPKFREAVKKHIPCLSGCLPASEEETKTKTRGQSSASASMSMTQTTAPV 0
0 HDPQASVDSGSSVSVDDSSGVSRQDTMMVK 0
0 VEVDKRMEKAGGGAADAAPQEGASVSTVSAQIEVRPSGKVTTKADVISTPQTAHGLSASPVPK 0
0 VAELGSSATLESAAIPGKIPTPLPSQPIAAPIERHMAAMADEPPPKPRGVATTVNVRRTESGYDRSQDSQRKK 0
0 VVGDTHRSRSFNTTKDHFASEQPAALIQPKELYSDDTTKKMARQSSEKHEYDNPAFDEGITEVDTDSENETEGSYDMLSVRFQAMAEEPPVETYRKASDLAINLGKASLMLSEAHDETVL* 0

>MEL6_braFlo Branchiostoma floridae (amphioxus) Deut.Ceph.Bran genomic 12435605 full Gq Amphiop6
0 MSPNLTNTSLLPNRTDRPELSPADVTMQLVFGSMMLVFGLIGVVGNAVALYAFCR 2
1 SRSLRRPKNYLIANLCLTDMVVCLVYSPIIVTRSLSHG 2
1 LPSKESCIVEGFVVGLGSIVSICSLAGIAVERYVTITQPIKSLSILTHRALLGAVSAVWVYAFLLAFPPLVGWGRYVSEESKISCTFDYLSTDDATRAHVIVLVIGAFGLPFSVITYCYV
RSFATVRKCTKERKQMSPLAKSDSRSEVKAAVNSFVITTSFCLCWCPYAVVATMGVSGFTVHSHAVFIAALLAKLSVLFNPVAYVLSIPSFRKALFSSSNDRTKYQTAFTFESLAKTSPV
ERKWCADSIERYRSSNVNIESTELTVPYSASRESCLLSRAATERLAGRSPSLTDIVREFGLQQTASHRETWV* 0

>MEL6_braBel Branchiostoma belcheri (amphioxus) Deut.Ceph.Bran AB050611 12435605 full Gq
0 MSSNLTNVSLVANRTDQTELSPTDVTMQLIFGSMMLVFGLIGVVGNVVALYAFCR 2
1 TRSLRRPKNYVVANLCLTDMFVCLVYCPIVVSRSFSHG 2
1 FPSKESCIVEGFMVGVGSIASICSLAAIAVERYLSVTQPLKSLTILTQRKLLVAVLTVWVYSLLLAFPPLVGWGRYVREETYISCTFDYLSTDDATRAYVITLVMGAFGFPLLTIAYCY
IRVFTTARKHAEERKFMSPLKRPESRTEIKTAVTACVITTSFCLCWCPYAVVATLGISGVSVQQQTVFSAALLAKLTVIINPIVYVLSIPNFRKALFAQEREKYASEDVVLTSLPGKTRRMK
KVERSQSSNSNVVIEVKESSMAYSTSRESCLLSRAATKRLAGKTKSIVDLVDEFGLQETAPHKESLV* 0

>MEL2_galGal Gallus gallus (chicken) Deut.Saur.Arch AY882944 17977531 full Gq syn(+GRID2+SMARCAD1 -PGDS -SEC24B +COL25A1)
0 MGTQPHSVTKSEIPDHVLYTVGTCVLVIGSIGIIGNLLVLYAFYS 2
1 NKKLRTPQNFFIMNLAVSDFLMSASQAPICFVNSLHREWILGDI 1
2 GCDLYAFCGALFGITSMMTLLAISVDRYLVITKPLRSIQWTSKKRTIQIIAAVWLYSLGWSVAPLLGW 1
2 SSYVPEGLMISCTWDYVTYSPANRSYTMILCCCVFFIPLIIILHCYLFMFLAIRSTGR 2
1 DVQKLGSCSRKSFLSQSMKNEWKLAKIAFVVIIVYVLSWSPYACVTLIAWAG 2
1 RGNTLTPYSKSVPAVIAKASAIYNPIIYAIIHPRYR 2
1 KTIHNAVPCLRFLIRISKNDLLRGSINESSFRTSLSSHQSLAGRTKNTCVSSVSTGEA 0
0 NWSDVELDTVEPAHEKLQPRRSHSFSSSLRQKRDLLPDSYSCSEETEEK 0
0 VSLSSSYLEKVLGRSAFPSSPVALVTSSLRAASLPVGLNSSSASRGAGSDISQMKTEESHNNGGLDSIVSNTVPQIIIIPTSETNLFQEEPEEEETELFHFHDKKNNLLDLEGLSSSTEFLEAVEKFLS* 0

>MEL2_anoCar Anolis carolinensis (lizard) Deut.Saur.Lepi genomic full Gq syn(+GRID2+ SMARCAD1 -ATOH1 +PDLIM5 +BMPR1B)
0 MGPHHRTKVDVPDHVLYTVGSCVLVIGCIGITGNLLVLYAFYS 2
1 NKRLRTPPNYFIMNLAVSDFLMSATQAPICFLNSMHKEWVLGDI 1
2 GCNLYAFCGALFGITSMITLLAISVDRYCVITKPLQSIKRTSKKRTCIIIVFVWLYSLGWSVCPLFGW 1
2 SSYIPEGLMISCTWDYVTYSPANRSYTMMLCCCVFFIPLVIIFHCYIFMFLAIRSTGR 2
1 RKSSISHSIKSEWKLAKIAFVAIVVFVLSWSPYACVTLISWAG 2
1 YARTLTPYSKSVPAVIAKASAIYNPIIYAIIHPRYR 2
1 RTIRSAVPCLRFLIPISKSDLSTSSMSESSFRASVSSRHSFSYRNKSTYISSISAKET 0
0 TWCDVELDPVESGHKKLQAYRSNSFSAKGVAEEESGLLLRTNNCNVPARKK 0

>MEL2_xenLae Xenopus laevis (frog) Deut.Amph.Anur genomic full Gq Xmop syn(SMARCAD1 +PDLIM5 +BMPR1B)
0 MDLGKTVEYGTHRQDAIAQIDVPDQVLYTIGSFILIIGSVGIIGNMLVLYAFYR 2
1 NKKLRTAPNYFIINLAISDFLMSATQAPVCFLSSLHREWILGDI 1
2 GCNVYAFCGALFGITSMMTLLAISINRYIVITKPLQSIQWSSKKRTSQIIVLVWMYSLMWSLAPLLGW 1
2 SSYVPEGLRISCTWDYVTSTMSNRSYTMMLCCCVFFIPLIVISHCYLFMFLAIRSTGR 2
1 NVQKLGSYGRQSFLSQSMKNEWKMAKIAFVIIIVFVLSWSPYACVTLIAWAG 2
1 HGKSLTPYSKTVPAVIAKASAIYNPIIYGIIHPKYR 2
1 ETIHKTVPCLRFLIREPKKDIFESSVRGSIYGRQSASRKKNSFISTVSTAET 0
0 VSSHIWDNTPNGHWDRKSLSQTMSNLCSPLLQDPNSSHTLEQTLTWPDDPSPKEILLPSSLKSVTYPIGLESIVKDEHTNNSCVR
NHRVDKSGGLDWIINATLPRIVIIPTSESNISETKEEHDNNSEEKSKRTEEEEDFFNFHVDTSLLNLEGLNSSTDLYEVVERFLS* 0

>MEL2_danRer Danio rerio (zebrafish) Deut.Acti.Otoc genomic full Gq syn(- +FLJ39155 +PDLIM5 -)
0 MEPQRQIYKRLDVPDHVHYIIAFLILIIGTLGVSGNALVMFAFYR 2
1 NKKLRSLPNYFIMNLAVSDFLMAITQSPIFFINCLYKEWMFGEL 1
2 GCKIYAFCGALFGITSMINLLAISIDRYLVITKPLQTIQWNSKRRTGLAILCIWLYSLAWSLAPLIGW 1
2 GSYIPEGLMTSCTWDYVSPSPANKSYTMMLCCFVFFIPLSIILYCYLFMFLSVRQASR 2
1 QKSSFVKQQSMRSEWKLAKIAAVVIVVYVLSWAPYACVTLVAWAG 2
1 HQDVLTPYSKTLPAVLAKSSAIYNPFIYAIIHNKYR 2
1 RTLAEKVPGLSCLSRSQKDGLSSSTNSDASAQDSSVSRQSSVSKNRLHSTMVQ* 0

>MEL2_tetNig Tetraodon nigroviridis (pufferfish) Deut.Acti.Perc genomic full Gq syn(- - - +BMPR1B)
0 MEPKDTHITSSFFSKVDVPDHVHYIIAFFVFVIGILGITGNVLVIFAFYS 2
1 NKKLRSLPNYFIVNLAVSDLLMASTQSPIFFINLYKEWMFGET 1
2 ACKMYAFCGALFGITSMINLLAISVDRYVVITKPLQTIRRSSKRRTALAILMVWLYSLAWSLAPLVGW 1
2 GSYIPEGLMTSCTWDYVTYTLANRSYTMMLCCFVFFIPLAIILCCYLLMFLAIRKTSR 2
1 RKSTLIQQKSIRSEWKLAKIAFVVIVVYVLSWSPYACVTLISWAG 2
1 YGSTLTPYSKSVPAVIAKASAIYNPIIYAIIHPRYR 2
1 KTIRSAVPCLRFLIPISKSDLSTSSMSDSSFRSALSCRHSYRSRSTYISSISAKET 0

>MEL2_takRub Takifugu rubripes (fugu) Deut.Acti.Perc genomic full Gq
0 MEPEDAHSPGSFINKVDVPDHVHYIVAFFVFVIGVLGMTGNVLVIFAFYS 2
1 NKKLRSLPNYFIVNLAVSDFLMASTQSPIFFINCLYKEWVFGEM 1
2 CKMYAFCGALFGITSMINLLAISIDRYVVITKPLQTIHWSSKRRTTLAILMVWLYSLAWSLAPLVGW 1
2 GSYIPEGLMTSCTWDYVTYTLANRSYTMMLCCFVFFIPLAIILSCYLLMFLAVRKTSR 2
1 RKSTLIQQKSIRSEWKLAKIAFVVIIVYVLSWSPYACVTLISWAG 2
1 HANILTPYSKAVPAIIAKASTIYNPFIYAIIHNKYR 2
1 MTLVEKFACLWFLSPTARKDCMSSSSISESSIRDSIISRQSTTSRSHFIAGSTRMVNVKSEMSLILNGP* 0

>MEL2_gasAcu Gasterosteus aculeatus (stickleback) Deut.Acti.Perc genomic full Gq syn(KNTC2 +FLJ39155 +PDLIM5 +BMPR1B)
0 MEPDNAHTQRSFINKVDVPDHAHYIVAVFVVVIGTLGITGNALVMLAVYS 2
1 NKKLRNLPNYFIMNLAVSDFLMAFTQSPIFFINCLYKEWAFGET 1
2 GCKIYAFCGALFGIASMINLLAISIDRYLVITKPLQAIHWGSKRRTTLAILLVWLYSLAWSLAPLVGW 1
2 GSYIPEGLMTSCTWDYVTYTLANRSYTMMLCCFVFFIPLGIILYCYLFMFLAIRKTSR 2
1 RKSTLIKQKSMKSEWKLAKIAFVVIVVYVLSWSPYACVTLISWAG 2
1 HADILSPYSKAVPAIIAKASAIYNPFIYAIIHNKYR 2
1 MTLAAKFPCLRFLSPTPRKDTSSSISESSYRDSVISRQSTASRTHFITACPDTVNFFFSFSSRLGCH* 0

>MEL2_oryLat Oryzias latipes (medaka) Deut.Acti.Perc genomic full Gq
0 MDPESTQGSLLSKVNVPDHAHYIVAMFVFVIGALGITGNALVMFAFYS 2
1 NKKLRNLPNYFIMNLAISDFLMAFTQSPIFFINCLYREWMFGET 1
2 GCKVYAFCGALFGISSMINLLAISVERYLVITKPLQTIHWSSKRKTTLAIFLVWFYSLAWSLAPLVGW 1
2 SSYIPEGLMTSCTWDYVTYTPANRSYTMMLCCFVFFIPLGIILYCYLRMFLSIRKTTr 2
1 RKSTVIQQKTIRSEWKLAKIAFVVIVVYVLSWSPYACVTLISWAG 2
1 HADILSPYSKAVPAVIAKASTIYNPIIYAIIHNKYR 2
1 MTLAEKVSCLRFLSPNPPKECTSYSFSESSFRDSIISRQSSVSRSHFINTLPSRADMVNDHKLVFI* 0

>MEL1_strPur Strongylocentrotus purpuratus (sea_urchin) Deut.Echi.Eleu XR_026330 frag G? opsin4 no cdna losing introns larval postoral arm ancestral intron
0 2
1 WTKSLRTPPNMLIVNLAISDFGMVITNFPLMFASTIYNRWLFGDA 1
2 GCQFYAFCGALFGIMSIANMTAIALDR 2
1 YYVICWSLEAVRSVTHRRSMIIIIIVWCYAIFWSIPPFFGVGSYVLEGYGLGCTFDFMTKDLNHYLHV
SFLFASSFVVPVTIIIVCFTRIAITVRAHRHELNKMRTKLTEDKDKKHKSSIRRANKAKTEFQIAKVGFQVTIFYVLSWM
PYSIVAVIGQYFDSDLLTPLGTVVPVIFAKCSAIWNPIIYCLSHEKFNAALKEKLMGMCGIEIPSKHRSMGSQESSVTGR
RGMHRQNSSTLSESSVTSTVDQDAIELKDRKQGPATVKVQQEKVEGGTYRRNPGDVTFSKDAGVEVDEKRRGDQGQRDDR
VRPQGEGQMDQWSQPPPAPASASAPTPGVNDKEYLTKM* 0

>MEL2_strPur Strongylocentrotus purpuratus (sea_urchin) Deut.Echi.Eleu DQ285097 full G? cdna: S droebachiensis retained intron: tube feet
0 MPTTLMENSTPGWMADDSQMEETHPAFPLIGGYLLVVVLLGTAGNSLVIYTFLRFKKLHSPINLLIVNLSASDLLVATTG
TPLSMVSSFYGRWLFGTNACAFYGFVNYYCGCISLNSLAAISVFRYIIVVRGQAQNNKLSLRSSIYAILVIHLYTLIFST
PPLYGWNRFVLAGYHTSCDIDFHTKTPLFVSYICYMFFFLFFLPLGLISWSYFKIYQRVSKHSNSMRTSFTGVTKEINSDEKHA 2
1 NHRRTASTLFVTIVVFLFAWFPYCIVSLWVLIGDANSISKLSTTIPSLFAKSSVIYNPLIYVVLNSKFRKALIQTLSFLKCLSKHELSESS* 0

>MEL1_plaDum Platynereis dumerilii (ragworm) Ecdy.Anne.Poly AJ316544 11874910 full Gq rhabdomeric melanopsin unavailable genomically
0 MSRSEVLVPGSMSLDGLLTTAHPIGNDSI 0
0 ETILHPYWQQFDIENTIPDSWHYAVAAWMTFFGILGVSGNLLVVWTFLK 2
1 TKSLRTAPNMLLVNLAIGDMAFSAINGFPLLTISSINKRWVWGKL 1
2 WRELYAFVGGIFGLMSINTLAWIAIDRFYVITNPLGAAQTMTKKRAFIILTIIWANASLWALAPFFGW 1
2 GAYIPEGFQTSCTYDYLTQDMNNYTYVLGMYLFGFIFPVAIIFFCYLGIVRAIFAHHA 2
1 EMMATAKRMGANTGKADADKKSEIQIAKVAAMTIGTFMLSWTPYAVVGVFGMIK 2
1 PHSEMFIHPLLAEIPVMMAKASARYNPIIYALSHPKFR 2
1 AEIDKHFPWLLCCCKPKPKAQLPSSTTKGSIASKTEADTSV* 0

>MEL1_capCap Capitella capitata (polychaete) Ecdy.Anne.Poly genomic full G? jgi 119596 distally uncertain shares 2 introns with melanopsins
0 MMSYADGYLDNSTAPIEESPYLPHGTFFHPHWRPYREMLLNMNPLIYYGLGLYMAVVGIVGTLGNLVVITLFIK 2
1 TRSLRTPPNMFIINLALSDMGFCATNGFPLMTVASFQKLWRWGPV 1
2 ACELYALAGSITGFNSIATLALISMDRYMVIAKPFYAMKHVSHKRSLIQIILAWTWAFIWSAPPLLRMGYGRYIP
EGFQVSCTFDYLSRDLKNLIFVWCLFVFGFFIPVLAIACSYVGIIRAVGAQSKEMRKTAEKMGAKTGKSDKEKKQDIAMAKVA
AGTIGLFLMSWTPYAAVSMIGIAGNRSWITPYVSQIPVMFAKASAMWNPILYALSHPKFRAALEDHMPWLLVC* 0

>MEL1_helRob Helobdella robusta (leech) Ecdy.Anne.Clit genomic full G?
0 MDSVTWYKDFHPHWWKYHDIIVNAPMAFYYFLGTFFAVVGFLGVFGNIIVVWVFSR 2
1 TPSLRTPSNVLVINLAICDILFSALIGFPMSALSCFQRHWIWGNF 1
2 YCQFYSFVAGITGLASINCLAVIAVDRYLVVGQPLAMLNQSHFRRSFYHVLIIWTWACVWSAMPLIGWGEYILEGFGVSCTFD
YLTRTTWNISFNVCLFTFCFGMPVSVIILSYIGIIRSIAKNRKEFSSLTAENSSRARQEIKIAKVFAVCMTAFILCWVPYAT
VAQLGIYGYDQMVSPYTAELPVMLAKTSALWNPIIYAFSHPKYRKCLKELPIFRQKRKFRFLGSKSHTKSSDGVGTIALTSTINRTATRH* 0

>MEL2_helRob Helobdella robusta (leech) Ecdy.Anne.Clit genomic frag G? from scaffold_391
1 TPILRTHANVLIINLALCDLIFSSLIGFPMTALSCFKRHWIWGDL 1
2 GCDFYGFVAGWTGLGSITCLAFISIDRYMAIVHPFYMLNKKSSSVLTLLQIGAVWSWALIWSVMPLFGWGRFIPEAFGVSCTFDYLTRTWSNICFNYVLITCGFFLPVVIIVTSYIGIVIEVTKS 1
2 VEEDGMKDHMDAQNARCYVFVAVLSM 0
0 LKTAKVLACCFGAFLICWTPYAIVAQLGINGFAHLVTPFTSEVPVLFAKTSSIWNPLIYALSHPRYRRAV 0

>MEL1_schMed Schmidtea mediterranea (planaria) Loph.Plat.Turb AF112361 10220416 frag G?
0 eVYHYLVGVYISIVGISGVLGNLLVLYIFAR 2
1 AKSLRTPPNMFIMSLAIGDLTFSAVNGFPLLTISSFNTRWAWGKL 1
2 TCEIYGFIGGLFGFISINTMALISLDRYFVIAQPFQTMKSLTIKRAIIMLVFVWLYSLIWSTPPFFGY 1
2 GNYVPEGFQTSCTFDYLTQSKGNIIFNIGMYIGNFIIPVGIIIFCYYQIVKAVRVHELEMLKMAQKMNASHPTSMKTG 1
2 AKKADVQAAKISVIIVFLYMLSWTPYAIIALMALTGRRDHLNPYTAELPVLFAKTSAMYNPFIYAINHPKFRIQLEKKFPCLICCCPPKPK 0
0 * 0

>MEL1_schMan Schistosoma mansoni (trematode_worm) Loph.Plat.Trem AF155134 11166392 full G? 6 exons
0 MKQNLTFATLWPDDNDFASIVHSHWHKFIQPDPLYYYLVGIYIGIVGILAVMGNSLVITLFLL 2
1 CKQLRTPPNMLIVSLAISDFSFALINGFPLKTIAAFNHRWGWGKL 1
2 ACELYGFAGSIFGFISLTTMAFIALDRYLVIVQPFETFSRITYGKVIVMIFITWIWSALWSIPPFFGY 1
2 GSYIPEGFHTSCTFDYLSTDLPNLIFNAGLYILGFLCPVFIIIFSYYQIVKTVRLNELELMKMAQSLDLQNPSAMKTg 1
2 GDKKADIEAAKTSIILVLLYLMSWSPYAIVCLMTLIGSRDSLTPFHSELPVLFAKTSAVYNPIVYAVKHPKFRMEIEKRFPFLICCCPPKPK 0
0 ERLQNTIVSKIQVSQIGIGTVSGGNENTLNTVKRED* 0

>MEL2_schMan Schistosoma mansoni (trematode_worm) Loph.Plat.Trem CD096414 12973350 full G?
0 MSSNRTIEMLRPYMKDFDSIVLPYWYKFEQPNPYYQYAIGLFIAVVGITGMCLNLLVIVFFTM 2
1 FKSLRTPSNILVVNLAISDFGFSAVIGFPLKTMAAFNNFWPWGKL 1
2 ACDLYGLAGGLFGFVSLSTIAAVALDRYLVIATPFESVFQTTPRRTLLLMLFLWMWSLMWTIPPLFGF 1
2 GRYVTEGYQTSCTMDYISTDLNNRLFNIGLFGFGFLCPLFLSLFCYARIILIVRSRGKDFIEMAASSKGTNQKEKSANV 1
2 SSSKSDTFVSKSSAILLGVYLICWTPYSFVCLMALIGYADYITPLMVEIPCLCAKTANPCIYAFRYPKFRSLLQQRFGFLRLTKNRVSY 0
0 ERSQHAILSTIHVVTDCQYGTVSGGNENTLNTFILLD* 0

>MEL3_schMan Schistosoma mansoni (trematode_worm) Loph.Plat.Trem XM_002581128 full G?
0 MSEIKNFTRSLLLYNRTFSMIKNNIHDSDIIMLNHWIKYTQPDPIYNYLVAIFVALIGIFGTITNLLVIFVFL 2
1 TPKSSISLQCALIINLAISDFGFSAVIGFPLKTIAAFNQYWPWGSV 1
2 ACQLYGFISATFGFLSLTTIAAISFDRYLVIVKDHKTTNFRVICTVIGFLWIWSIIWTIPPFFGF 1
2 GRYVLEGYQTSCTFDYISNDMPSLLFSGGMYIFGFMFPVLLCIYCYVNLLKIVRNNERVVLISLSNDGASKQRESVR 1
2 NRKRLDIEATKSVILSLLFYLMSWTPYAMVCLISILGQSYFLTPTIAEMPHIFAKMAAIYNPILYAFTNRKFKNALGIRKTSSVIMQQQRLLSKGQLKPLVSLLFLVN* 0

>MEL1_lotGig Lottia gigantea (limpet) Loph.Moll.Gast FC774055 full G? ests long tail omitted 3 exons best: molluscan melanopsins
0 MTTLPPKENTTHLFDTWDDMFVHPHWKNFPPVSAAWHNFIGIFITFVGITGVIGNFVVIYTFSR 2
1 TKSLRTASNMFVVNLALSDLTFSAVNGFPLFSLSSFSHKWIFGRV 1
2 ACELYGLIGGIFGLMSINTMAMISIDRYLVITSPFTAMRNMTHKRAFLMIVGVWIWSILWAIPPIFGWGAYIPEGFQTSCTFDYLTRGDNRRSYIMCLYICGFVVPLGVIIFCYVFIIKSVMNHEKE
MAKMADKLDAKDVRSTKEKAKAEIKIAKVSMTIILLYLMSWTPYAIVALIAQWGPALVVTPYVSEIPVLFAKASAMHNPVIYALSHPKFRDAVSKLMPWFLCCCGLTDAEKKARDELAKSKFTRQT* 0

>MEL1_sepOff Sepia officinalis (octopus) Loph.Moll.Ceph AF000947 900420 full G? similar X56788 Loligo forbesi
0 MGRDIPDNETWWYNPTMEVHPHWKQFNQVPDAVYYSLGIFIGICGIIGCTGNGIVIYLFTK 2
1 TKSLQTPANMFIINLAFSDFTFSLVNGFPLMTISCFIKKWVFGMA 1
2 ACKVYGFIGGIFGLMSIMTMSMISIDRYNVIGRPMAASKKMSHRRAFLMIIFVWMWSTLWSIGPIFGWGAYVLEGVLCNCSFDYITRDSATRSNIVCMYIFAFCFPILIIFF
CYFNIVMAVSNHEKEMAAMAKRLNAKELRKAQAGASAEMKLAKISIVIVTQFLLSWSPYAVVALLAQFGPIEWVTPYAAQLPVMFAKASAIHNPLIYSVSHPKFREAIAENFPWII
TCCQFDEKEVEDDKDAETEIPATEQSGGESADAAQMKEMMAMMQKMQQQQAAYPPQGAYPPQGGYPPQGYPPPPAQGGYPPQGYPPPPQGYPPAQGYPPQGYPPPQGAPPQGAPPQ
AAPPQGVDNQAYQA* 0

>MEL1_todPac Todarodes pacificus (squid) Loph.Moll.Ceph X70498 11106382 full Gq squid rhodopsin 3D Cys 337 palmitoyled
0 MGRDLRDNETWWYNPSIVVHPHWREFDQVPDAVYYSLGIFIGICGIIGCGGNGIVIYLFTK 2
1 TKSLQTPANMFIINLAFSDFTFSLVNGFPLMTISCFLKKWIFGFA 1
2 ACKVYGFIGGIFGFMSIMTMAMISIDRYNVIGRPMAASKKMSHRRAFIMIIFVWLWSVLWAIGPIFGWGAYTLEGVLCNCSFDYISRDSTTRSNILCMFILGFFGPILIIFF
CYFNIVMSVSNHEKEMAAMAKRLNAKELRKAQAGANAEMRLAKISIVIVSQFLLSWSPYAVVALLAQFGPLEWVTPYAAQLPVMFAKASAIHNPMIYSVSHPKFREAISQTFPWVL
TCCQFDDKETEDDKDAETEIPAGESSDAAPSADAAQMKEMMAMMQKMQQQQAAYPPQGYAPPPQGYPPQGYPPQGYPPQGYPPQGYPPPPQGAPPQGAPPAAPPQGVDNQAYQA* 0

>MEL1_entDof Enteroctopus dofleini (octupus) Loph.Moll.Ceph X07797 full Gq
0 MVESTTLVNQTWWYNPTVDIHPHWAKFDPIPDAVYYSVGIFIGVVGIIGILGNGVVIYLFSK 2
1 TKSLQTPANMFIINLAMSDLSFSAINGFPLKTISAFMKKWIFGKV 1
2 ACQLYGLLGGIFGFMSINTMAMISIDRYNVIGRPMAASKKMSHRRAFLMIIFVWMWSIVWSVGPVFNWGAYVPEGILTSCSFDYLSTDPSTRSFILCMYFCGFMLPIIIIA
FCYFNIVMSVSNHEKEMAAMAKRLNAKELRKAQAGASAEMKLAKISMVIITQFMLSWSPYAIIALLAQFGPAEWVTPYAAELPVLFAKASAIHNPIVYSVSHPKFREAIQTTFPWL
LTCCQFDEKECEDANDAEEEVVASERGGESRDAAQMKEMMAMMQKMQAQQAAYQPPPPPQGYPPQGYPPQGAYPPPQGYPPQGYPPQGYPPQGYPPQGAPPQVEAPQGAPPQGVDNQAYQA* 0

>MEL1_aplCal Aplysia californica (sea_hare) Loph.Moll.Gast AASC01108363 full Gq 4 exons uncertainties
0 MNVSSSLTSQPYHELLHPHWLEHEEAPEGVHLSVGVFITLVGVLAVCGNSLVIITCIR 2
1 FKDLRTRSNILIINLAVGDLLMCLIDFPLLAAASFYGEWPYGRQ 1
2 VCQMYAFLTAIAGLVTINTLAVIAADRYWAVVRRPTPGQKLPKCVTSIAVASVWAYSISWALCPILGWGAYVLDGIRTTCTFDFLTRTWENRSFVIGMMIGNFVLPFALMVFSYFRIWVAVRKVKSG 2
1 NVFCAIRHNYNLALGSTLFVKQHRYRLHCEQKTVKIIMFLLIAFTVSWSPYLAVSIIGLFGDRSQLTYQNTLTASLIAKTSMVFNPILYSISHPKVRKRIANLACCYSVRRHQQQTSRIKTGRRSTSSATPSRS* 0

>MEL2_aplCal Aplysia californica (sea_hare) Loph.Moll.Gast AASC02005512 frag G? 1st exon missing; new 3rd intron
0 2
1 HSSLRTSSNLLVVNLTVADLVMSSLDFPILAISSYKGCWVMGFL 1
2 GCQVYGVSSGVAGLVTINTLAAISVDRFVVVVHRLSPMHQMGKSTT 1
2 GVIIIAIWALSVIWAVLPITGVSSYRLEGMGTSCTFDYASRTSSNRWFFIALVIFNFFIPLALIIFSYWRIYASVRAVKRELKLLQSARTSILRKRFEVQAEI
KTAITALVIISIFCLAWTPYVIIAFVGLYGPTTAIDPLVSMFPNILAKISTVSNPILYSIGHPEVRKKMKKLFLPGQQDSSWRATSATAGNSSPAQSENMNNISLPTYL* 0

>MEL2_lotGig Lottia gigantea (limpet) Loph.Moll.Gast genomic full G?
0 MSIASHVWTNSSTNHFNFSVLHQHWQNQTPLSTACQYTIGIFISTVAVIAVIGNSIVIWAHVR 2
1 IKSLSTTSNMLILNLCVGCLIMCIVDFPLYATSSFLQKWIFGHK 1
2 VCEIYATITGTAGLLIMNSYSAIAFDRFITVTRYNNPNYPRSKSATMCISGFVWIYSLSWSMAPVVGWSRYQLDGSGTT
CTFDYLSTTWTNRSFILSIAFFNFVLPLCFILFAYSRILHLISSHSREMKSYRSAVIISKGKASIPKRFRSERKTAITLLI
TVVVFCLSWVPYVIIALIGQFGNQSFITPQISVIPQLVAKLSTVTNPILYSLSHPVVRNKLFLRLRHELYRRPSDSVSSSRGIQMKNIEFI* 0

>MEL1_patYes Patinopecten yessoensis (scallop) Loph.Moll.Gast AB006454 9287291 full Gq retina
0 MADNKSTLPGLPDINGTLNRSMTPNTGWEGPYDMSVHLHWTQFP PVTEEWHYIIGVYITIVGLLGIMGNTTVVYIFSN 2
1 TKSLRSPSNLFVVNLAVSDLIFSAVNGFPLLTVSSFHQKWIFGSL 1
2 FCQLYGFVGGVFGLMSINTLTAISIDRYVVITKPLQASQTMTRRKVHLMIVIVWVLSILLSIPPFFGWGAYIPEGFQTSCTFDYLTKTARTRTYIVVLYLFGFLIPLIIIGVC
YVLIIRGVRRHDQKMLTITRSMKTEDARANNKRARSELRISKIAMTVTCLFIISWSPYAIIALIAQFGPAHWITPLVSELPMMLAKSSSMHNPVVYALSHPKFRKALYQRVPWLF
CCCKPKEKADFRTSVCSKRSVTRTESVNSDVSSVISNLSDSTTTLGLTSEGATRANRETSFRRSVSIIKGDEDPCTHPDTFLLAYKEVEVGNLFDMTDDQNRRDSNLHSLYIPTRVQHRPTTQSLGTTPGGVYIVDNGQRVNGLTFNS* 0

>MEL1_dapPul Daphnia pulex (water_flea) Ecdy.Crus.Bran genomic full G? no close homologs
0 MTSSNDSAGYLWAINATIWIIDDSNETLGIDWDDWDVSLWTQEQRQLLEHGGIPRQVHVALGVLLSFIVLFGFAANSTILYVFSR 2
1 FKRLRTPANVFIINLTICDFLACCLHPLAVYSAFRGRWSFGQT 1
2 GCNWYGMGVAFFGLNSIVTLSAIACERYIVITSSSCRPVVAKWRITRRQAQK 0
0 VCAGIWLHCAALVSPPLLFGWSSYLPEGVLVTCSWDYTSRTLSNRLYYFYLLFFGFFLPVSVLTFCYAAIFRFILRSSKEITRLIMTSDGTTSFSKSTVSFRKRRRQTDVRTALI
ILSLAILCFTAWTPYTIVSLIGQFGPVDEDGELKLSPMVTSIPAFLAKTAIVFDPLVYGFSSPQFRNSVRQILRQQSISSSGNAGNRAGPNNMAMARTAIQNSRASSHATVSSF
SRNARMFPKDPLSKKTPNDPFVSTPLAVQQIPHFRLPTDVDINEQQFRRGIYANKSVSYWIDIIVLLQLGENLRKSCMKRKNSFKIPAGSIPQKNKLSNSRCSLLEDVSTHSLA
LRQMIFRKEGELYLFHHQPSHNAELAANKMDHQGNNKRIRRRFSEADMMHRSGKCRKNLPVSTSFDQ* 0

>UV7_ixoSca Ixodes scapularis (tick) Ecdy.Chel.Arac genomic frag G? exon 1 missing exon 2 disjunct K90 at EIP XM_002408275 wrong
0 2
1 RRRIRSQANLLVFNLALSDLLMVLEIPLLVYNSLKLRPALGVW 1
2 GCQLYGLMGGLSGTSAIFSIAALSLERYLALGRPRDPFARLTRSRAFALSLSSWIYALCFSAWPLLGVTSPYVPEGFLTSCSFHFLSDATSDRCFVWIFFVAAWCVPLVFVTTCYSGILVTVIRSRKALAQES
RRSELRVAKVSLALVLLWTVAWTPYAIVALLGITGRRNLLTPWGSMAPAMFCKSAAVLDPFVYGLSHPSFRRELAIMLPCLRPRQRPVSLTLRAVVQLPKRPGPRSAGSSTSVPVTAPGTTKDNHCPTPPNVSR* 0

>UV7_tetUrt Tetranychus urticae (spider_mite) Ecdy.Chel.Arac GW013907 frag G? larval transcripts
AGCKIYGFFGGLSGTSAIMTIAMMAMERLNSISKPLSPHSRLSMRRALVISTLIWIYSLIFSTPPVFHLFNRYVPEGYLTSCSFDYLSKDLVSRIYIFAFFTAAWIVPLTLIVTSYVGIIIAVERNETMFQKTQDRLCERAS
SVYRASLRDSRGRSVKESGKMEMRLVKIVLSLIAFWILSWTPYAIIALLGLLDQSYITPTSSMIPAIFAKLSSVVNPYLYGLGNPRFKRELKRKLCFCVANKASVERRTVIQSTVTLGDPKEGTQFVHISDGNLSEIELSDYENR* 0

>UV7a_dapPul Daphnia pulex (water_flea) Ecdy.Crus.Bran frag ACJG01004266 tandem1
0 MLNHTHSISRETIHGNAICDQHRKFVNLYPVDVWKSSGFFDDIDLMDINCHWLQFEPPTPSSHFMLAIIYSVVFVIGFVSNTAIVYILLR 2
1 SKKLLTPANILLVNLAISDLLIISMIPIFLYNSFLQGPAIGGL 1
2 GCKVYGFLSGFSGTSTILTLAAIAIDRYLVISRPLDLAKKPTRTWAYATIAITWLYSATFASLPFLGAGKYVPEGYLTSCSFDYLSEDTGTRVFIFIFFVAAWVCPLT IITFCYAAITYVNICSTNTARPLIIIQHKYAGWRQCNIEIAIPKIVAGLVLSWIIAWTPYSLISLLGISGHTDLLTPLSSMLPALFAKTAACVDPFIYSLNHPKIRQEII 

>UV7b_dapPul Daphnia pulex (water_flea) Ecdy.Crus.Bran genomic ACJG01004266 full tandem2
0 MNAINMCNQTNCATDVVTDDIIERWKLCGFFEDDDFLDINCHWLQFEPAPLVNHLLLVCIFVFILLTGCLCNIIVIYIFAR 2
1 SRHLRTPANIIIMNLAISDFFMLIKMPIFLYNSLLQGPALGIK 1
2 GCQIYGFMSGLTGTTSIMSLATVAVDRYLVISQPLNVNRKSTRTRAYLTTCFIWLYSAIFASLPLFGIGKYVPEGYLTSCSFDYLSNNVKTRSFILAFFLAAWLFPFCIITTCY
TAITYVNICSTNTARPLIIIQHKYAGWRQCNIEVVIAKIVVVLVAMWMISWTPYAFVALLGISGTQTRLTPGMTMFPALFAKFSACVNPIIYTLTHPKIKKEILRRWYCFMSSGTS 

>UV7a_acyPis Acyrthosiphon pisum (aphid) Ecdy.Inse.Hemi SCAFFOLD4798 full G? 3 exons altered HEK K90
0 MIDFKTKYPVNLWKDHGLYTDDYIKLINSHWLKFMPPNPTSHYVLGLLYTVIMVFGCTGNSLVIFMYFK 2
1 CRSLQTPANMLIINLAVSDFIMLAKASVFIYNSYYLGPALGKL 1
2 GCQVCGFLGGLTGTVSIMTLAAISLDRYYVIVCPLKAAVKTTKQRARIWIGLIWIYGFSFSIVPVLDLGYSRYVSEGYLTSCSFDYLSDNDQDKRFI
LVFFTAAWCIPFTIILYCYVNILMAVWMTTEIVTSRVGQQEEKRKTDIRLGYMVIGALALWFVSWTPYAVVALLGVFDLKEYISPLSSMIPALFCKAAS
CTDPWFYAITHPRFKKELMKLLTKSKSRKLVRNYGMKKGWVGSHLNKNGSVDFDNCLKTEYKEENTTIFMLESDDNNLHCQGSTSGHKTESTKEPETKFTASASQETLKYMLPS* 0

>UV7b_acyPis Acyrthosiphon pisum (aphid) Ecdy.Inse.Hemi SCAFFOLD14504 full G? altered HEK CL3 K in in K90
0 MSDFKTKYPIDTWKEHGFYTDDYMKLINSHWFKFMPPNATSHYILGFLYSVIMVLGCFGNSLVIFMYIK 2
1 CKSLQTPANVLIMNLAVSDFIMLAKTPVFIYNSFYQGPTLGKL 1
2 GCQIYGFFGGLTGTVSIMTLAAISLDRYYVIVHPLNAAVKTTKQRARVWIGLIWIYGFLFSIIPVMDLGYNRYVPEGYLTSCSFDYLSDDNQEKGFILVFFTAAWCIPFTTISYCYIKI
LRAVWMTSEMAASRFGQEEEKRKTEIRLGYVVVGVIMLWFVSWTPYAMVALLGVFDRKDYITPLSSMIPAVLCKAASCMDPWIYAITHPRFKNELTKLMSRKKTRKLERDYGMKKNWGGQ
SYSNKSGAGLRNLSSSEDECVEEVIVVIDPDDKKMKRQGSTSSHKTEETKALETKFPPTRQESLKYMPPSWYKLPRTTSKSSIMLDPKLTGDDNNK* 0

>UV7_rhoPro Rhodnius prolixus (kissing_bug) Ecdy.Inse.Hemi genomic full G? K90 at KMP ortholog RH7 of droMel
0 mKYFHLYPIEQWKMHRFFTEEYLKLVNTHWFEYPPPNKQIHYIFAAVYFLVMLVGVSGNLLVIFMILR 2
1 FRTLRTSSNILILNLAVSDFLMVAKMPVFIYNSFYFGPVLGEM 1
2 GCHFYGFIGGLSGTASILTLAAIAMDRYLGIAHPLNFNQGRAKKRTIVWITFIWVYSITFASIPLSHIGVKTYVPEGFLTSCSFDYLSTDIQNRCFIFIYFVAAWCLPLLVIITSYVGICREVLRVSLIRKGQE
REQRKREAKLSAILALATFLWFLSWTPYAAVALLGIFGYKNHITQLASMIPALFCKTAACVNPFIYGLNHPRLRQQLLKLCCKKRYNLEKTHFSRSWRNTSCSFKLKEQSLCNVSQSRLRRTSTVASEPSEHSTHFM* 0

>UV7_pedHum Pediculus humanus (louse) Ecdy.Inse.Phth AAZO01007270 full G?
0 mKTFKLKWPEEWKKLGLFDDEYLYKINKYWMKFPPPSPMSHYFMGIIYSVIMVVGVFGNFLIIYLFLR 2
1 KRSLRTPSNVFIFNLAVSDSLLLLKMPVFIINSFYLGPALGNL 1
2 GCSAYGFVGGLTGTVSIMTLAAIAFDRYQVIVHPLERKTKAAVYFQILLIWIYAIFFSIIPLLDVGLNKYVPEGYLTSCSFDYLTQDTASRLTIFVFFVAAWIVPLSIILGSYM
ALYKVVLKARGTHFNTVMTRHCKDIEIQRPELKAAVTVICIVCLWTLSWTPYAVVALLGITGNEKYISPMSSMIPALFCKTASCIDPFVYAATNRRFRNELKRKYRKRSRYQPSLKTE
RKDFFTLSEDNNDRGKGNTIRIREK* 0

>UV7_spoLit Spodoptera littorali (butterfly) Ecdy.Inse.Lepi FQ016398 FQ021555 Cfrag male antenna 
MFSTIGCWGNIIVLLMYLRCRTLRTPGNILVANLALSDFLMLAKTPIFIFNSFNLGPALGKTGCVIYGFVGGLTGTTSIATLSAIALDRYWAVVRPLEPL
RALTAIRARLLAIGAWLYACVFAIIPALDIGYGSYVPEGYLTSCSFDYLTEDFSPRCFIFVFFCAAWLAPFCTITFCYISIFRVVVFNTSMSYGNQDQRL
SSRHVKERTKRKAEIKLAFLVMAVIALFFISWTPYAIVALLGITGKKDVLTPITSMIPALFC

>UV7_mayDes Mayetiola destructor (hessian_fly) Ecdy.Inse.Dipt AEGA01002257 frag genomic
1 VYFLHSSYNGYPDTKVLESINIHWIGFNPPKPWEHYTLAIMISIIMTIGLIGNFLVICM 2
1 SRILKRASNILLLNLAFADFFMLAKSPIYIYNCLKFGPASGDL 1
2 ACRAYGFIGGLTGTVSIMTLSAISFDRYMGIMYPFNTEKFGNKKIRAFILVAFVWFYSFTFAIMPALNIGLSKYTPEGFLTSCGFDYLDNQTSARIFMFTFFIGAWMIPFLTITYCYIQIFRV
VNLTRQIQSNRKRQRAEQKLAIVVMNLIAIWFFAWTPYAIVALLGIAGQQQYITPWASMIPALFCKASACINPYIYSIRYPEFKQEIFRILSKYFKFADEHLQQNATRTMSVHFVTRTRVQINEQY* 0

>UV7_anoGam Anopheles gambiae (mosquito) Ecdy.Inse.Dipt XM_308329 full G? K90=EAP
0 MGRQGSGNAVRISPSSRNQPYFSSAHLSFVVPFPVHSKYVVRSGYVLPVDPLFVAKINPFWLRFDPPSAGEHYGLAVFYFLMMLFGVIGNALVVFMFYR 2
1 YRSLRTPANYLVINLAVADFIIMMEAPMFIYNSIHQGPALGSI 1
2 GCTVYALMGAVGGTVAIATLTVISIDRYNVVVYPLNPNRSTTKLKCYFLIAFTWAYGLLFASFPALEIGLSRYTAEGYLTACSFDYLDRTYKARVFMFVYFVFAW
LIPFAIISYCYARILIAVINANAIQSSKSKNKTEVKLAGVVVGIIGLWFAAWTPYAVVAMMGVFGYEQYLTPLNSMIPAVFAKIAASIDPYFYAMNHPRYRQMLER
MFCNRGADQGNSQYQTSHYTRGASRGGDSEGGGGEESGGGGGVGRAPGGGNAGLGRGGTVRGGGGGGRLIAGKGGGGANATGSTGGGGVKALKKQISNGDETSLEVSLEM* 0

>UV7_aedAeg Aedes aegypti (mosquito) Ecdy.Inse.Dipt XM_001650694 frag G? wrong exon 1 K90=EAP
0 FPPNSRYMALSGYSGPTIEDAFRDRINPFWLQFDPPSRTAHYILGFIYFMMMMFGLCGNLLVILMFFR 2
1 FKSLRTPANYLVINLAIADFIIMLEAPLFVYNSYHQGPATGNVWCTIYALLGAVGGTVAIVTLTMISIDRYNVVVYPLNPKRSTTRLKVALMIVF
AWIYGLVFSVIPALDIGLSRYTPEGFLTACSFDYLERTRDARLFMFLYFIFAWVVPIIAITFCYIQILRVVIGANSIQSSKNKSKTEVKLAGVVIGIIGLWFIAWTPYAIVAMMGV
FGYESLLSPLGSMVPAILAKTAACIDPYFYAMNHPRYRQELRKMFGLNQQDLGNSQYQTSRYTRNASRMDDSEGGASERVTIGRQPGKTTTDEPEPSQQTEQGPQPTYSKNLAANS
RGALQRAQSSISAADDTSLSVSIDLTETNPNSNH* 0

>UV7_culQui Culex quinquefasciatus (mosquito) Ecdy.Inse.Dipt XM_001861603 frag G? wrong exon 1 K90=EAP
0 PEPVHPASKYISLSGYDGPPVEDAFRDRINPFWLQFEPPSPVAHYALGFVYFLMMVWGLFGNVLVIFMFFK 2
1 FKSLRTPANYLVINLAVADFLIMLEAPIFVYNSYHLGPAFGNTL 1
2 CTIYSLLGAIGGTVAIMTLTMISVDRYNVVVYPLNPNRSTTRLKVMLMIVFTWIYALVFSL
MPALEIGLSRYTPEGFLTACSFDYLDRGWDARVFMFMYFVFAWVIPFLTISYCYVAILRVVVGAGSIQSSKNKNKQEVKLAGVVIGIIGLWFIAWTPYAVVAMLGVFGYEHLLTPL
GSMIPAILAKTASCIDPYFYAMNHPRFRQELRKMFGKEQEMNHSQYQTSRYTRNASRNDSEAGPSERVQLGRAPGKDADPIPAVSSSVAQPNYSQNLASNRKGGLQRAQSSISAAD
DTSLSCSIDLTETQPNNH* 0

>UV7_bomMor Bombyx mori (moth) Ecdy.Inse.Lepi BGIBMGA012539 full G? kaikoblast
0 MSEILDRRSNVSGEVKETRLPIKYSKYEVNELVSSEANNEVLIKKFKELWPVNLWRRFGLFTDDYLHLVNPYWLSFAPPHPLLHYGLGAFYIMMTTVGSTGNALVMFMYFR 2
1 CRSLRTPGNILVANLALSDFMMLAKTPIFIFNSFNLGPALGKT 1
2 GCVIYGFVGGLTGTTSIAILTAISLDRYWAVVRPLEPLRALTAIRARLMAIAAWIYATLFAIIPALDIGYGRYVPEGFLTSCSFDYLTEELPPRYFIFVFFCAAWLAPFCTISYC
YISIFRVVVCSRNITTKNQEQRLSTRHVKERTKRKAEIKLAFLVIVVIALFFISWTPYAIVALLGIFGKKDLIKPLTSMIPALFCKTAACINPFIYIITHPKFRKEFKRMLSRDKTE
RSGTIKTIGYYTEASKFHRPSKDFSDTEVEIVEMKDIPYRNEDTTNTVEEKINTVSAKLAKREGSQKSQSSISMKSFEENVVSPPSWYCKPKFAKKKSFHRRSTHSMVSQNTDPTV* 0

>UV7_droMel Drosophila melanogaster (fruitfly) Ecdy.Inse.Dipt NM_079311 full G? RH7 long N-terminal has M comp genomics support 2 of 3 exons novel
0 MEAIIMTTLPNLTTDAGDSSFWLTGALSLSEMLANSSHSHSTGSTTSTAGSSATESSAVNVGKDHDKHVNDSVSTGLS 2
1 NYSNYPSYIHYRDKYDLSYIAKVNPFWLQFEPPKSSTFLIMAALYCLISVVGCVGNAFVIFMFANRKSLRTPANILVMNLAICDFLMLIKCPIAIYNNIKEGPALGDI 1
2 ACRLYGFVGGLSGTCAIGTLTAIALDRYNVVVHPLQPLRRCSRLRSYLIILLIWCYSFLFAVMPALDIGLSVYVPEGFLTTCSFDYLNKEMPARIFMALFFVAAYCIPLTSIVYSYFYILKVVFTASRIQSNKDKAKTEQ
KLAFIVAAIIGLWFLAWSPYAIVAMMGVFGLERHITPLGSMIPALFCKTAACVDPYLYAATHPRFRVEVRMLFYGRGVLRRVSTTRSSYMTRSRSSFTHRLRTSTTGEGGMGDHRMENYLMNNNLMMVPEETEENEEIVVVAEINNSISSVMEQSKF* 0

>UV7_droYak Drosophila yakuba (fruitfly) Ecdy.Inse.Dipt genomic 12209654 full G? RH7 chr3L:12207286 12209654
0 MEAIIMTTLPALTTDAGDSSSFWLTGALSLSEMLANSSHGHSTGSTSSTAGSSATESSTVNVGKDHDVTKHVNDSVSTGLS 2
1 NYSNYPSYIHYRDKYDLSYIAKVNPFWLQFEPPKSSTFLVMAALYFLISVVGCVGNAFVIFMFANRKSLRTPANILVMNLAICDFLMLIKCPIAIYNNIKEGPALGDI 1
2 ACRLYGFVGGLSGTCAIGTLTAIALDRYNVVVHPLQPLRRCSRLRSYLIILLIWCYSFLFAVMPALDIGLSVYVPEGFLTTCSFDYLNKETPARIFMALFFVAAYCIPLTSIVYSYFYILKVVFTASRIQSNKDKAKTEQ
KLAFIVAAIIGLWFLAWSPYAIVAMMGVFGLERHITPLGSMIPALFCKTAACVDPYLYAATHPRFRVEVRMLFYGRGVLRRVSTTRSSYMTRSRSSFTHRLRTSTTGDGGMGDHRMENYLMNNNLMMVPEETEENEEIVVVAEINNSVSSVMEQSKF* 0

>UV7_droAna Drosophila ananassae (fruitfly) Ecdy.Inse.Dipt genomic full G? RH7 scaffold_13337 frameshifted
0 MEAIILSTLPSLTTNASGSSSHWLTGALSLPEILANSSGSPNTSSADTGSGINLSARDADRHFNISTEAR 2
1 NYSYYPGYIHYRDKYDLSYIAKVNPFWLQFEPPHSSTFLAMAALYCLISVVGCVGNAFVIFMFANRKSLRTPANILVMNLAICDFLMLVKCPIAIYNNIKEGPALGDV 1
2 ACRIYGFVGGLSGTCAIGTLTAIALDRYNVVVHPLQPLRRCSRLRSYLIILLIWCYSFLFAVMPALDIGLSVYVPEGFLTTCSFDYLNKETPARIFMALFFVAAYCFPLTAIVYSYFYILKVVFSAGRIQSNKDKAKTEQ
KLAFIVAAIIGLWFLAWSPYAVVAMMGVFGLEKHITPLGSMIPALFCKTAACVDPYLYAATHPRFRVEVRMLFYGRGILRRVSTTRSSYMTRSRSSFTHPAGRADGGTGRDHRMETYLMNNNLMMVPEETEENEEIVVVAEINNSVSSAIEQSKF* 0

>UV7_droPse Drosophila pseudoobscura (fruitfly) Ecdy.Inse.Dipt genomic full G? RH7 chrXR_group6:2491547 2493151
0 MEALMAALPTLTTEAAGSSLWLTSALSLSEMLANSSTSPNASLVAATTSSAAVATASTTSAAEAVGKVPDKHEVNDNVSTVLS 2
1 TSSSYPGYIHYRDKYDLSYIARVNPFWLQFEPPKSSTFYLMAALYCLISVVGCVGNAFVIFMFANRKSLRTPANILVMNLAICDFLMLVKCPIAIYNNIKEGPALGDA 1
2 ACRIYGFVGGLSGTCAIGTLTAIALDRYNVVVHPLQPLRRCSRLRSYLIIFLIWSYSFLFAVMPALDIGLSVYVPEGFLTTCSFDYLNKETPARIFMALFFVAAYCVPLTTIVYSYFYILKVVFTASRIQSNKDKAKTEQ
KLAFIVAAIIGLWFLAWSPYAIVAMMGVFGQERHITPLGSMIPALFCKTAACVDPYLYAATHPRFRVEVRMLFFGRGVLRRVSTTRSSYMTRSRSSFNRRLRPTPDAEHRVESYLMNNNLMMVPEETEENEEIVVVAEFNNSSYSGMEQSKF* 0

>UV7_droWil Drosophila willistoni (fruitfly) Ecdy.Inse.Dipt genomic full G? RH7 scaffold_180949
0 MDMDMALDMNDAATTTSLWITSAALSLSEILVNTTSHVVTTSPASTSTVETTAVAAVTATGKVVHDDEKHHHHHHHHHQDEVNDNNVTTVLR 2
1 NFSSYPGYIHYRDKYDLSYIAKVNPFWLQFEPPRSSTFYIMAALYCLISVVGCIGNAFVIFMFSNRKSLRTPANILVMNLAICDFLMLVKCPIAIYNNIKEGPALGDI 1
2 ACRIYGFVGGLSGTCAIGTLTAIALDRYNVVVHPLQPLRRCSRLRSYLVIVMIWCYSFLFAIMPALDVGLSVYVPEGYLTTCSFDYLNKETPARIFMALFFVAAYCVPLTCIMFSYFYILKVVFTANRIQSNKDKAKTEQ
KLTFIVAAIIGLWFLAWSPYAVVAMMGVFGLEQHITPLGSMIPALFCKTAACVDPYLYAATHPRFRVEVRMLIYGRGVLRRVSTTRSSYITRSRSSFTRRLRTGSELDMRTEPYIMNNNLMMVPEETEENEEIVVVAEINNPSRCVSMHEHTSKF* 0

>UV7_droMoj Drosophila mojavensis (fruitfly) Ecdy.Inse.Dipt genomic full G? RH7 scaffold_6680
0 METIMSTLPTLTADDGSLWITSALTELLASGANSSSGSSSVVADGTQNATFVAAATTTTTTVAAAAAAAAAAAVNASTATTANATKGHHKHPHGVNDSETDLR 2
1 LCSSYPGYIHYRDKYDLTYIAKVNPFWLQFEPPDTSTFYIMAALYCLISVVGCVGNAFVIFMFGSRKSLRTPANILVMNLAICDFLMLVKCPIAIYNNIQEGPALGDA 1
2 ACRLYGFVGGLSGTCAIGTLTAIALDRYNVVVHPLQPLRRYSRLRSYLIIFAIWCYSFLFAVMPALDVGLSVYVPEGFLTTCSFDYLNKETPARIFMALFFVAAYCIPLASIVYSYFYILKVVFTANRIQSSKDKAKTEQ
KLTFIVAAIIGLWFIAWSPYAIVAMMGVFGQEQHITPLGSMIPALFCKTAACVDPYLYAATHPRFRVEVRMLMYGRGVLRRVSTTRSSYMTRSRSSFTHRLRPSSGDCENRAEPYTLNNNLMMVPEETEENEEIIVVAEINNSISGVMEQSKF* 0

>UV5_plePay Plexippus paykulli (jumping_spider) Ecdy.Chel.Arac AB251851 18217181 full G? PpRh3 kumopsin3
MLNNTIPGPATLDDIGPPSWCYETRFNGWNAAPDIYVPDYWKQFRAPAPYLHYMLGFFYICLMSIAVV
GNAIVMYIFFSAKTLRTPTNMFVIGLAMADLLMMSKTPVFIYNCFHLGPVFGQIGCDIYGIVGTYSGIGSAFCNAIIAYDRYRVIVHP
FSKSGMSITKAIAFLVIIYLYITPFAILPALKIWSRYVPEGFLTSCSADFFMQDFNGRSYIV
GTWFFGWFIPVAAIVFFYVQIFLAVKDHEEKIKEQARKMNVDSIRSNEAVKNSSAEVRIAKTAMCVFLMFLSSWAPYILVAFITGFSDPKLKRITPVISMVPAMTIKASACFDPFF
YALSHPRYRLELQNRMPWLCINEKAEASGPADDSVSKTTEHVA*

>UV5_hasAda Hasarius adansoni (jumping_spider) Ecdy.Chel.Arac AB251848 18217181 full G? HaRh3 kumopsin3
MLNNTALQPAVLDDIGPPSWCYETRFNGWNAAPDILVPDYWKQFRAPAPYLHYILGCLYICLMSVALI
GNAIVIYIFSVSKSLRTPTNMFVIGLAMADLLMMSKTPVFIYNCFHLGPVFGQLGCDIYAIVGTYSGIGSAFCNAVIAYDRYRVIVHP
FSKSGMTMTKAIAILVIVYLYITPFAILPALKIWSRFVPEGFLTSCSSDFYMQDFNGRSYIV
GTWFFGWFIPVAAIIFFYAQIFLAVKDHEEKIKEQARKMNVDSFRSNEALKNSSAEVRIAKTAMCVVLLFLTSWVPYILVAFIAGFSDPKLKRVTPVISMIPAMTIKGSACFDPFF
YALSHPRYRLELQNKLPWLCINEKAEASGPADDSVSKTTEHVA*

>UV5_braKug Branchinella kugenumaensis (fairy_shrimp) Ecdy.Crus.Bran AB293436 18984904 full G?
MANVTGFDYYRYERRELGWNTPAEYMEFVHPHWKQFEAPNPFLHYMLGVFYIIFMFCSLIGNGVVIWVFASAKSLRTPSNLFVINLAVLDFLMMLKTPVFIVNSFNEGPIWGKTGCDFFALLGSYAGIGGATTNAAIAFD
RYRTIAHPFDGKLSRGQAITLCMLCWLYATPFSLMPFFGIWGRFVPEGFLTTCSFDYITEDSSTRAFVGTIFFTSYVLPMILIIYFYSQIVGHVRQHEETLRAQAKKMNVATLRSGKDDQEQSAEVRIAKVCIGLFSMFV
ISWTPYAAVALLCAFGNRAAVTPLVSMIPALTCKAVACIDPWIYAINHPRYRLELQKRLPWFCIHEPEPNNDSASVNSEKTVATTTPS*

>UV5_triLon Triops longicaudatus (tadpole_shrimp) Ecdy.Crus.Bran AB293435 18984904 full G?
MAFLQNQTYDGTSPSFSFFRTSERIMLGHNTPKDYMEYVHPHWQTFEAPNPFLHYLLGVLYIGFMFCALVGNGVVIWIFSSAKSLRTPSNMFVINLAVLDFIMMMKTPVFIVNSFNEGPIWGKFGCDLFALMGSYSGIGG
AMTNAAIAFDRYRTIARPFDGKLSRGKVLTICAGIWLWATPFSLMPLFGIWGRFVPEGFLTTCSFDYMTETSSIRWFVGCIFTYSYIIPLGLIIYYYSKIVGHVQEHERILREQARKMNVESLRSGKDQQEKSAEIRIAK
VAIGLSLMFVVAWTPYALVALIAAFGNRAVLTPLVSMIPACCCKAVACIDPWIYAINHPRYRLELQKRMPWFCVHEPEPEMIDNSSAITEKTST*

>UV5_triGra Triops granarius (tadpole_shrimp) Ecdy.Crus.Bran AB293430 18984904 full G?
MAFLQNQTHDGTSPSFSFYRTSERVMLGQYTPKDYMDYVHPHWQTFEAPNPFLHYLLGVLYIGFMFCALVGNGVVIWIFSSAKSLRTPSNMFVINLAVLDFIMMMKTPVFIVNSFNEGPIWGKFGCDMFALMGSYSGIGG
AMTNAAIAFDRYRTIARPFDGKLSRGKVLTICAGIWLWATPFSLMPLFGIWGRFVPEGFLTTCSFDYMTETSSIRWFVGCVFTYSYIIPLGLIVYYYSKIVGHVQEHERILREQARKMNVESLRSGRDHQEKSAEIRIAK
VAIGLSLMFVVAWTPYALVALIAAFGNRAVLTPLVSMIPACCCKAVACIDPWIYAINHPRYRLELQKRMPWFCVHEPEPEIIDNSSAITEKTST*

>UV5a_dapPul Daphnia pulex (water_flea) Ecdy.Crus.Bran FE384049 full G?
0 MLGWNTPEDYMSYVHP 2
1 YWKTFEAPNPFLLYMIGFLYTIFMFCCVAGNGVVIWIFTN 2
1 CKSLRTPSNMLVVNLAILDMLMMLKSPVMIINSYNEGPIWGKLGCDVFGLMGSYNGIGSAVNNAAIAYDRHR 2
1 TISRPLDGKLSRKQVTLMIVAIWAWATPFSVMPFLGIWGRYVP 1
2 EGFLTTCTFDYMTEDASTRFFVGSIFVYSYVIPLAMLIFYYSKIVRSVGDHEKTLRDQAKKMNVTSLRSNRDQNEKSAEVRIAKVAIALATLFVFAWTPYAFVALTAAFGNR 2
1 SVLTPLLSTVPACCCKLVSCINPWIYAINHPRYR 2
1 MELQKKMPWFCIHEPVPTNDDSSVGSATTEMSGVSKETSS* 0

>UV5b_dapPul Daphnia pulex (water_flea) Ecdy.Crus.Bran genomic full G? penultimate intron lost last intron has slid back 2 aa
0 MNGWNTPADYKSYVHPHWLSYEEPNPMLHHLLGVLYIFFMIASCLGNGIVIYIFST 2
1 TKELKTPSNILILNLAICDFIMMIKTPIFIVNSFNEGPVFGRLGCSIFGLLGAYVGPCSAVTNAAIAYDRYR 2
1 CISDPMGKRWSKSQASLIVLGCWVYASPVSLLPFTEIVNRFVP 1
2 EGYLTSCTFDYMTDNLETKMFVFILWIWCWIMPLGVIIFSYGKITTQVMTHEARLKEQAKKMNVESLRSGANKDARNEIRVAKVGISLTTLFLLSWTPYFAIAFIGCYGNR SLLTPGLSMIPACTCKMAACVDPFVYAINHPK 2
1 YRLELMKRFPWLCVHEKDDSTRSENSTNATIASEAESRT* 0

>UV5_triCas Tribolium castaneum (flour_beetle) Ecdy.Inse.Cole genomic full G?
0 MYVVHPFKIIRNKVTILRTMETMANHLGWNVPKDELIHIPQHWLVYPEPEASMHFLLALIYIGFFIMATIGNGLVIWIFST 2
1 SKSLRTASNMFVVNLAICDFAMMIKTPIFIYNSFYRGFALGHLGCQIFAFIGSLSGIGAGMTNACIAYDRYT TITRPFDGKITRTKALVMIIFVWGYTIPWAVMPLLEIWGRFAP 1
2 EGFLTACSFDYLTDTFDNHMFVTSIFICSYVIPMSMIIYFYSQIVSKVFSHEKALREQ 0
0 AKKMNVESLRSNQSQQASQSAELRIAKAAIAICSLFVASWTPYAVLALIGAFGDQSLLTPGVTMVPACACKFVACLDPYVYAISHPKYR 2
1 LELQKRLPWLAIKETAASETQSTTTENTTTQSATTTT* 0

>UV5_lucCru Luciola cruciata (firefly) Ecdy.Inse.Cole AB300329 19232386 full G?
MILHNATVFAAAQTQDDPDSIVHLLGWNVPKSELHHIPEHWLVYPEPEASIHYLLGIVYIFICFMGIVGNGLVLWIFSTSKSLKTASNMFVVNLAFCDFIMM
MKMPIFVYNSFNRGYALGHIGCQIFGFVGSLSGIGAGMTNAFIAYDRYATISNPLEGKLTRTKALIMIFIIWGYTFPWAVLPMFEVWCRFVPEGFLTSCTFDYLTDTFDNDMFVAV
IFICSYVIPMSMIIYFYSQIVKHVMHHEKALRDQAKKMNVESLRSNQSLQSQSIEIKIAKVAIMVCFLFVASWTPYAVLALIGGFGDQSLLTPGVTMVPALACKFVACLDPYVYAL
SHPRYRMELQKRLPWLAIKEDAVSDAQSMVTTTTAAATPAATEQAPTA*

>UV5_anoGam Anopheles gambiae (mosquito) Ecdy.Inse.Dipt XM_556823 full G? novel short exon
0 MGLVQLDNQTAYRPEALIGADQSGLRYLGWNVPPEELVHIPEHWLQFPEPEASLHYLLGLLYIAFTIFSLVGNGLVIWIFIA 2
1 AKSLRTPSNVFVINLAICDFFMMAKTPIFIYNSFTKGFTLGNLGCQIFGFVGSLT 1
2 GIGAGATNALIAYDR 2
1 YNTITRPFEGRLTQTKAIIFICLIWAYTIPWGVLPLLEIWGRYVP 1
2 EGFLTSCTFDYLSGTFDTRLFVASIFTFSYVLPMSLIIYYYSQIVSHVVNHEKSLREQAKKMNVESLRSNQNQKDASVEIRIAKAAITVC
FLFVASWTPYAVLALIGAFGDKSLLTPGVTMFPACACKFVACLDPYVYAISHPRYRIELQKRLPWLAITETLPAENASTCTEQQDGNATTQS* 0

>UVB_anoGam Anopheles gambiae (mosquito) Ecdy.Inse.Dipt XM_312478 full G?
0 MFLGNESISEGAMLMPMARTAGEMPKLLGWNLPPEEQYLVHDHWKGFPSPPYYMHLMLAMIYFVLMNTSLIGNGIVLWIFGT 2
1 SKSLRNGSNMFIINLAIFDLLMMCEMPMFLVNSFSERLVGYGVGCSVYAALGSMSGIGGAISNAVIAFDRYRTISNPLDGRLSRVQAGLLICLTWLWTMPFTLLPLFEIWGRY
IPEGYLTTCSFDYLTDDPDTRVFVGCIFTWAYVIPMIFICYFYARLFGHVRQHEMMLKNQARKMNVESLTANRSEKAQAVEMRIAKAAFTIFFLFVCAWTPYAIVTMIGAFGDR 2
1 TMLTPFVTMVPAVCCKIVSCLDPWVYAISHPKYRQELERRLPWMGIKEADDSVSTTES* 0

>UV5B_droMel Drosophila melanogaster (fruitfly) Ecdy.Inse.Dipt NM_057748 19398933 full G? RH5 two small introns also seen in Apis and Daphnia
0 MHINGPSGPQAYVNDSLGDGSVFPMGHGYPAEYQHMVHAHWRGFREAPIYYHAGFYIAFIVLMLSSIFGNGLVIWIFST 2
1 SKSLRTPSNLLILNLAIFDLFMCTNMPHYLINATVGYIVGGDLGCDIYALNGGISGMGASITNAFIAFDRYKTISNPIDGRLSYGQIVLLILFTWLWATPFSVLPLFQIWGRYQP 1
2 EGFLTTCSFDYLTNTDENRLFVRTIFVWSYVIPMTMILVSYYKLFTHVRVHEKMLAEQAKKMNVKSLSANANADNMSVELRIAKAALIIYMLFILAWTPYSVVALI
GCFGEQQLITPFVSMLPCLACKSVSCLDPWVYATSHPKYRLELERRLPWLGIREKHATSGTSGGQESVASVSGDTLALSVQN* 0

>UV4_droMel Drosophila melanogaster (fruitfly) Ecdy.Inse.Dipt NM_057353 19949290 full G? RH4 one ancestral intron with intercolated genes
0 MEPLCNASEPPLRPEARSSGNGDLQFLGWNVPPDQIQYIPEHWLTQLEPPASMHYMLGVFYIFLFCASTVGNGMVIWIFST
SKSLRTPSNMFVLNLAVFDLIMCLKAPIFIYNSFHRGFALGNTWCQIFASIGSYSGIGAGMTNAAIGYDRYNVITKPMNRNMTFTKAVIMNIIIWLYCTPWVVLPLTQFWDRFVP 1
2 EGYLTSCSFDYLSDNFDTRLFVGTIFFFSFVCPTLMILYYYSQIVGHVFSHEKALREQAKKMNVESLRSNVDKSKETAEIRIAKAAITICFLFFVSWTPYGVMSLI
GAFGDKSLLTPGATMIPACTCKLVACIDPFVYAISHPRYRLELQKRCPWLGVNEKSGEISSAQSTTTQEQQQTTAA* 0

>UV3_droMel Drosophila melanogaster (fruitfly) Ecdy.Inse.Dipt NM_079687 9165115 full G? RH3 single exon
0 MESGNVSSSLFGNVSTALRPEARLSAETRLLGWNVPPEELRHIPEHWLTYPEPPESMNYLLGTLYIFFTLMSMLGNGLVIWVFSAAKSLRTPSNILVINLAFCDFMMMVKTPIFIYNSFH
QGYALGHLGCQIFGIIGSYTGIAAGATNAFIAYDRFNVITRPMEGKMTHGKAIAMIIFIYMYATPWVVACYTETWGRFVPEGYLTSCTFDYLTDNFDTRLFVACIFFFSFVCPTTMITYY
YSQIVGHVFSHEKALRDQAKKMNVESLRSNVDKNKETAEIRIAKAAITICFLFFCSWTPYGVMSLIGAFGDKTLLTPGATMIPACACKMVACIDPFVYAISHPRYRMELQKRCPWLALNEKAPESSAVASTSTTQEPQQTTAA* 0

>UV5_acyPis Acyrthosiphon pisum (aphid) Ecdy.Inse.Hemi SCAFFOLD14509 full G? 8 exons K90
0 MDFNRTVSRPLAQLGs 2
1 SLMENEVGETHLLGWNLQAEDLIHIPEHWLKYQEPSSLQHYYLAFMYTIFMFVALFGNGLVIWVFCV 2
1 AKPLRTPSNIFVINLALCDFVMMAKAPIFILGSINRGYQ GHFLCQLFGTAGAFSGIGASATNAAIAYDRFS 2
1 TIAKPFDGRMTYGRAFFLIICIWTYTLPWGLLPLTEKWNRYVP 1
2 EGYLTSCTFDYLSPTDETRAFVGIMFVICYVIPVSLVIFFYSQIVSHVFNHEKALREQ 0
0 AKKMNVESLRSNQDANAQSAEVRIAKAAITICCLFIASWTPYAVVAMIGAFGDR 2
1 SLLTPGITMIPAIFCKTVACFDPYVYAISHPRYR 2
1 LELSKRVPCLGISEKPPPTASETQSTTTAA* 0

>UV5_rhoPro Rhodnius prolixus (kissing_bug) Ecdy.Inse.Hemi genomic frag G? exon 1 missing K90 at KTP
0 0
1 ASTSGNIRTLGWNLSPEDLKHIPEHWLSYPEPEPILNYALGVLYIFFMLIALIGNGLVIWIFST 2
1 AKTLRTPSNIFVVNLAICDFLMMSKTPIFIYNSFKLGYALGHRACQIFALLGSFSGIGASATNAVIAYDRYR 2
1 VIATPFAPKLSRTKAVLYLALVWAYVTPWALLPLFEQWSRFVP 1
2 EGFLTSCTFDYLTPTSEIRNFVTVMFFICYVFPMSLIIYFYSQIVSHVIIHEHNLREQ 0
0 AKKMNVESLRSNANMHTQSAEIRIAKAAITICFLFVASWTPYAVLALIGAYGNQ 2
1 DLLTPAVTMIPACACKAVACVDPYVYAISHPRYR 2
1 QELSKKFPWLDIKEAPAPSSVDANSTATEMTLPTQTSPAEA* 0

>UV5_apiMel Apis mellifera (bee) Ecdy.Inse.Hyme AF004169 9502802 full G? 5 exons
0 MSNDSIHWEARYLPAGPPRLLGWNVPAEELIHIPEHWLVYPEPNPSLHYLLALLYILFTFLALLGNGLVIWIFCA 2
1 AKSLRTPSNMFVVNLAICDFFMMIKTPIFIYNSFNTGFALGNLGCQIFAVIGSLTGIGAAITNAAIAYDRYS 2
1 TIARPLDGKLSRGQVILFIVLIWTYTIPWALMPVMGVWGRFVPEGFLTSCSFDYLTDTNEIRIFVATIFTFSYCIPMILIIYYYSQIVSHVVNHEKALREQAKKMNVDSLRSNANTSSQSAEIRIAK 0
0 AAITICFLYVLSWTPYGVMSMIGAFGNKALLTPGVTMIPACTCKAVACLDPYVYAISHPKYR 2
1 LELQKRLPWLELQEKPISDSTSTTTETVNTPPASS* 0

>UV5_attCep Atta cephalotes (ant) Ecdy.Inse.Hyme wgs ADTU01002850 full 83% bee
0 MVNESIHWEARVLSAEPIRLLGWNVPAEELIHIPEHWLIYPEPNPSLHYLLAIVYIIFTFVALLGNGLVIWIFCS 2
1 AKSLRTSSNLFVVNLAFCDFFMMIKAPIFIYNSFNTGFATGHLGCQIFAFIGSLSGIGAGMTNAAIAYDRYS 2
1 VIARPLDGKLSRGQVILFIVLIWAYTIPWALMPIMHVWGRFVPEGFLTSCTFDYLTDTPEIQYFVATIFTFSYCIPMSLIIYYYSQIVNHVIDHEKALREQAKKMNVESLRSNVSANTQTMEIRIAK 0
0 AAITVCFLFVLSWTPYGVLAMIGAFGDKTLLTPGITMIPACTCKFVACLDPYVYAISHPRYR 2 
1 LELQKRLPWLELQEKSTDTQSSTSEVVNVPSS* 0

>UV5_nasVit Nasonia vitripennis (jewel_wasp) Ecdy.Inse.Hyme XM_001608024 full G? gene wrong transcripts GE436449 GE390962
0 MPYYNWNGTDQTAGWPEARIQPAGAPRLLGWNVPPEELVHIPEHWLVYPEPNPALHYLLALLYILFTFVALLGNGLVIWIFCA 2
1 AKSLRTPSNMFVVNLAICDFMMMLKTPIFIYNSFHTGFALGNLGCQIFSFIGSLSGIGASITNAAIAYDRYS 2
1 TIARPLDGKLSRGQVMMLIVLIWMYTIPWALMPSMGVWGRFVP EGFLTSCTFDYITDSDEIRYFVGTIFTFSYAIPMTLIIYFYSQIVGHVVNHEKALREQAKKMNVESLRSGQNKDQASAEVRIAK 0
0 VALTICFLFVAAWTPYGVMSLIGAFGNK SLLTPGVTMIPACCCKAVACLDPYVYAISHPRYR 2
1 LELQKRMPWLELQEKPPASDATSTTTEAVPASS* 0

>UV5_papXut Papilio xuthus (butterfly) Ecdy.Inse.Lepi AB028218 full G? Rh5
0 MIPAAVMDNHTENNYNYGAYFAPYRLEGVELLGAGLTGEDLAAIPEHWLSYPAPPASAHTMLALVYVFFTAAALIGNGLVIFIFSASKSLRTPSNLLVVQLAVLDFLMMLKAPIFIYNSIK
RGFASGVIGCQIFAFMGSVSGTAAGLTNACIAYDRHSTITRPLDGRLSRGKVLLMMVCVWLYTAPWAILPQLQIWGRYVPEGFLTSCTFDYLTTTFD
NKLFVASMFVCVYIFPMIAILYFYSGIVKQVFAHEAALREQAKKMNVDSLRSNQNAAAESAEIRIAKAALTVCFLYVASWTPYGVMSLIGAFGDQNLLTPGVTMIPALACKGVACI
DPWVYAISHPKYRQELQKRMPWLQIDEPDDNASNTTSNTANSSAPA* 0

>UV5_bomMor Bombyx mori (moth) Ecdy.Inse.Lepi BABH01012019 -------- frag G? ---
0 1 
2 VEMLGDGLSGDDLAAVPEHWLTFPAPPASAHTALALLYIFFTAAALLGNGLVIFVFST 2
1 TKSLRTSSNLLILQLAILDFIMMAKAPIFIYNSAMRGFATGTIGCQIFSVMGAYSGIGAGMTNACIAYDR 2
1 HSTITRPLDGRLSKGKVLLMMAFVWIYCTPWALLPLLKIWGRYVP 1
2 EGYLTSCTFDYLTNTFDTKLFVACIFVCSYVFPMSMIIYFYSGIVKQVFAHEAALR 2
1 EQAKKMNVESLRANQSGASQSAEIRIAKAALTVCFLFVASWTPYGVMALIGAFGDQQLLTPG 0
0 VTMIPAVACKAVACIDPWVYAISHPKYR 2
1 QELQRRMPWLQINEPDDTTSTATSNTVSSAPPAAPA* 0

>UV5_manSex Manduca sexta (moth) Ecdy.Inse.Lepi L78081 9343857 full G? Manop2
0 MNNQSENYYHGAQFEALKSAGAIEMLGDGLTGDDLAAIPEHWLSYPAPPASAHTALALLYIFFTFAALVGNGMVIFIFSTTKSLRTSSNFLVLNLAILDFIM
MAKAPIFIYNSAMRGFAVGTVGCQIFALMGAYSGIGAGMTNACIAYDRHSTITRPLDGRLSEGKVLLMVAFVWIYSTPWALLPLLKIWGRYVPEGYLTSCSFDYLTNTFDTKLFVA
CIFTCSYVFPMSLIIYFYSGIVKQVFAHEAALREQAKKMNVESLRANQGGSSESAEIRIAKAALTVCFLFVASWTPYGVMALIGAFGNQQLLTPGVTMIPAVACKAVACISPWVYA
IRHPMYRQELQRRMPWLQIDEPDDTVSTATSNTTNSAPPAATA* 0

>UV5_pedHum Pediculus humanus (louse) Ecdy.Inse.Phth AAZO01000117 full G? exon 1 uncertain
0 MKITTESENNISLSYYQPF 1
2 IDKEESLIWNVDPSELVHIPDHWFNFSAPHPLSNYLLGFLYFIFFVISCTGNGIVIWIFTT 2
1 SKNLRTASNVFVVNLAIFDFIMMAKTPIMIYNSMNLGFECGFVWCQIFASAGALSGIGASITNTCIAYDRCE 2
1 TITNPLQ KSGKKKAFLLAAFTWIYALPWAVLPFLEIWGKFAPEGYLTTCTVDYLTDTSQTRMFIVTIFFAAYVLPLSLIIYFYTKIVLHVINHEKSLKAQ 0
0 AKKMNVESLRSDGNKNYAVEIRITKVAIAMCFLFVISWTPYAVVALIGCFGNK 2
1 HLITPLVSMIPACACKAVACIDPYIYAISHPRFR 2
1 VEVNKRFACLAGCLQEKELQDDAVSKNTVNAENVDT* 0

>UV5_diaNig Dianemobius nigrofasciatus (cricket) Ecdy.Inse.Orth AB458852 full G?
MELQGSNVSNLSVWRPEARLATRLLGWNVPAEELIHIPEHWLTYPAPDAFSYYILGMLYVAFCFIALIGNGLVIWVFSSAKTLRTPSNIFVINLALYDFIMM
LKTPIFIYNSFNLGFGLGQLGCQIFAFMGSVSGIGAAATNACIAYDRYRVIARPFDSKMSIKGATLLVLLVWMWALPWAILPLLEIWGRYAPEGYLTSCSFDYLTDTPENHMFVLC
IFICSYVIPMSLIIYFYSQIVSHVVNHEKALKEQAKKMNVDSLRSNQQQNQTSAEIRIAKVAIGICFLFVASWTPYAVLALIGAFGNKALLTPGVTMIPACTCKAVACLDPYVYAI
SHPRYRAELQKRLPWLCIKEESASDTTSNATTTSTNAGATST* 0

>UVB_acyPis Acyrthosiphon pisum (aphid) Ecdy.Inse.Hemi SCAFFOLD14509 full G? 8 exons K90
0 MDFNRSVSRPLSQLGS 2
1 SFMENEEELQLMGWNLTPEDLTHIPEHWLSYPEVRSLYHYILAFSYTILFCLGVIGNGLVLWIFCV 2
1 SKPLRTPSNLFVLNLALCDFSMVLVLPILIYDSIDHKYP GHLQCQIFALCGSISGIGAGATNAAIAYDRYS 2
1 TIAKPFEGRMTYGKALILIICIWIYVLPWCLLPLTEKWNRFVP 1
2 EGFLTSCSFDYLTPTEETKAFVGTMFVICYVIPMSFIIYFYSQIVCHVFNHEKALREQ 0
2 AKKMNVESLRSNQDANAQSAEVRIAKAAITICFLFVAAWTPYAVVAMIGAFGDQ 2
1 SLLTPIASMLPAVFAKTVACFDPYVYAISHPKYR 2
1 LELSKRVPCLGITEKPLATSDTQSITTAA* 0

>UVB_megVic Megoura viciae (vetch_aphid) Ecdy.Inse.Hemi AF189715 10762427 full G?
MDFNRSVSRPLSQLGSSFMENEDELQLMGWNLTPEDLTHIPEHWLSYPEVRSLYHYILAFSYTILFCIGVI
GNGLVLWIFCVSKPLRTPSNLFVLNLALCDFSMVLVLPILIYDSIDHKYPGHLQCQIFALCGSISGIGAGATNAAIAYDRYSTIAKP
FEGRMTYGKALILIICIWIYVLPWCLLPLTEKWNRFVPEGFLTSCSFDYLTPTEETKAFVGTMFVICYVIPMSFIIYFYSQIVCHVFNHEKALREQAKKMNVESLRSNQDANAQ
SAEVRIAKAAITICFLFVAAWTPYAVVAMIGAFGDQSLLTPIASMLPAVFAKTVACFDPYVYAISHPKYRLELSKRVPCLGITEKPPAASDTQSITTAA* 0

>UVB_apiMel Apis mellifera (bee) Ecdy.Inse.Hyme AF004168 9502802 full G? 8 exons
0 MLLHNKTLAGKALAFIAEEG 2
1 YVPSMREKFLGWNVPPEYSDLVHPHWRAFPAPGKHFHIGLAIIYSMLLIMSLVGNCCVIWIFST 2
1 SKSLRTPSNMFIVSLAIFDIIMAFEMPMLVISSFMERMIGWEIGCDVYSVFGSISGMGQAMTNAAIAFDRYR 2
1 TISCPIDGRLNSKQAAVIIAFTWFWVTPFTVLPLLKVWGRYTT 1
2 EGFLTTCSFDFLTDDEDTKVFVTCIFIWAYVIPLIFIILFYSRLLSSIRNHEKMLREQ 0
0 AKKMNVKSLVSNQDKERSAEVRIAKVAFTIFFLFLLAWTPYATVALIGVYGNR 2
1 ELLTPVSTMLPAVFAKTVSCIDPWIYAINHPR 2
1 YRQELQKRCKWMGIHEPETTSDATSAQTEKIKTDE* 0

>UVB_attCep Atta cephalotes (ant) Ecdy.Inse.Hyme wgs ADTU01025579 ADTU01025580 frag 74% bee
0 2
1 DVQPLQEEHFLGWNFPPEHADLVHPHWRVFLAPGRLWHVALALIYFLLLMLSLLGNGIVIWIFST 2
1 SKSLRTPSNIFILNLAVFDLLMATEMPMLIINSFLERTIGWETGCDVYALLGAISGMGQAITNAAIAFDRYR 2
1 TISCPIDGRLNGKQAMVLALFTWFWALPFSILPMTGLWGRYVA 1
2 EGFLTTCSFDYLTDDEDTRTFVITIFFWAYVLPMLLIIYFYSQLLKSIRSHEKMLRDQ 0
0 AKKMNVKSLVSNQNKERSVEMRIAKVAFTIFFLFVLAWTPYAVVALIGAYGNR 2
1 EALTPFSTMLPAIFAKTVSCIDPWIYAINHPR 2
1 YRQELEKRCKWMGIREKVAEDTVSAQTEKVNAEET* 0

>UVB_nasVit Nasonia vitripennis (jewel_wasp) Ecdy.Inse.Hyme XM_001604572 full G?
0 MAFVGLNGAMGGMGPA 1
2 EKPLQRYSQGPQMQEHLLGWNHPPEHIDIVHPHWRGFLAPGKYWHIGLALIYFMLLVLSFVGNGCVVWIFST 2
1 SKVLRTPSNLFIINLALFDLVMALEIPMLIINSFIERMIGWGLGCDIYAALGSVSGIGSAITNAAIAYDRYR 2
1 TISCPIDGRLNGKQAAVMVAFTWFWTMPFTILPFAKIWGRYTT 1
2 EGFLTTCSFDFLSDDQDTKVFVAAIFSWSYCFPMVLIIYFYSQLIKSVRRHEKMLREQ 0
0 AKKMNVKSLSAQDKERSVEMRIAKVAFTIFFLFVCSWTPYAVVTMIAAFGNR 2
1 ELVTPFSSMLPAVFAKTVSCIDPWVYAINHPR 2
1 YRQELTKRCQWMGIHEPDSGPSQNNAEAVSVTTEKLKSDDA* 0

>UVB_bomMor Bombyx mori (moth) Ecdy.Inse.Lepi BABH01016294 -------- full G? ---
0 MALNFTQEISDIGPMAYPLKM 2
1 VSREMVEHMLGWNIPEEHQDLVHEHWRNFPSVSKYWHYCLALIYAMLMVTSLVGNGIVIWIFGT 2
1 SKSLRSASNMFVINLAIFDLMMMLEMPLLIINSFYQRLVGYQLGCDIYAVLGSLSGIGGAITNAVIAFDRYK 2
1 TISCPLDGRINKVQASLLIAFTWFWALPFTILPAFRIWGRYVP 1
2 EGFLTTCSFDYFTDDQDTKVFVACIFVWSYCIPMTLICYFYSQLFGA 0
0 VRLHERMLQEQ AKKMNVKSLAANKEDASRSVEIRIAKVAFTIFFLFVCAWTPYAFVTMTGAFGDR 2
1 NLLTPIATMVPAVCCKVVSCIDPWVYAINHPR 2
1 YRAELTKRLPWLGVRESDPDAVSTTTSVGTAQSQATAEA* 0

>UVB_manSex Manduca sexta (moth) Ecdy.Inse.Lepi AD001674 9343857 full G? exons from 454
0 MATNFTQELYEIGPMAYPLKM 2
1 ISKDVAEHMLGWNIPEEHQDLVHDHWRNFPAVSKYWHYVLALIYTMLMVTSLTGNGIVIWIFST 2
1 SKSLRSASNMFVINLAVFDLMMMLEMPLLIMNSFYQRLVGYQLGCDVYAVLGSLSGIGGAITNAVIAFDRYK 2
1 TISSPLDGRINTVQAGLLIAFTWFWALPFTILPAFRIWGRFVP 1
2 EGFLTTCSFDYFTEDQDTEVFVACIFVWSYCIPMALICYFYSQLFGA 1
0 VRLHERMLQEQAKKMNVKSLASNKEDNSRSVEIRIAKVAFTIFFLFICAWTPYAFVTMTGAFGDR
1 TLLTPIATMIPAVCCKVVSCIDPWVYAINHPR 2
1 RAELQKRLPWMGVREQDPDAVSTTTSVATAGFQPPAAEA* 0

>UVB_diaNig Dianemobius nigrofasciatus (cricket) Ecdy.Inse.Orth AB291232 full G?
MNSSVGLQGAPIALPYESYVAQMLGWNIPAEHIELVHSHWRGYEAPSKYWHYWFAFMYFCIMIMSCLGNGIVLWIFATTKSLRTPSNMFVVNQALLDLLMMI
EMPMFVLNSLFYQRPIGWEMGCDIYALLGAVSGIGSAINNAAIAYDRYRTISFPLDGRLQFGHALAFIVGVWSWAMPFSLLPLLKVWGRYVPEGLLTTCSFDYLTDDEDTKVFTAS
IFTWSYAFPLCLIVFFYCKLFKQVRLHEKMLQEQARKMNVKSLQTNQDVAQKSVEIRIAKVAFTIFFLFLCSWTPYATVAMIGAFGNRALLTPMSTMIPALFSKIVSCIDPWIYAI
NHPRFRGELLKRAPWFGVEELKSSDVSSIGTDRTTATAAIETPAA* 0

>LMS_ixoSca Ixodes scapularis (tick) Ecdy.Chel.Arac EW898719 full G? ocellar transcripts
0 MGSEGQRTNMSLLDELASPYMKNGTLVESVPDEMLYMVHPHWYNFKPMNPLWHSLLGFAMVILGVISVVGNSMVIYIMTTSKSLRSPTNMLVVNLAFSDW 2
1 CMMAFMMPTMAANCFAETWILGPFMCEVYGMVGSLFGCGSIWSMVMITLDRYNVIVRGVAAAPLTHKRAALMIFFVWFWALTWTLLPFFGWSR 2
1 YVPEGNMTSCTIDYLTKALWSASYVVAYAGGVYWTPLFINIYCYSKIVRAVAQHEKQLRLQARKMNVASLRANAEQTKTSAEARLAK 0
0 IALMTVGLWFMAWTPYLTIAWAGIFSDGSKLTPLATIWGSVFAKANACYNPIVYGISHPKYRAALARRFPSLVCMPPGGDQLDTRSEASGITTIEDKVMTTET* 0

>LMS_tetUrt Tetranychus urticae (spider_mite) Ecdy.Chel.Arac GW028305 frag G? larval transcripts
CEFYGMWGSLFGCGSVWSLVFITRDRYNVIVRGMSAGRLTIKKSLAQVLFIWFYSVAWTIIPFFGWSRYVPEGNMTSCTIDYLSKDLWNASYTVVYAVAVYFLPLFTLVYHYYYIVCAVATHERTLREQA
KKMNVASLRANADANKESADIRIAKVAMMTVGLWFMAWTPYCTLAFLGIFTDGDYLTPMVSIWGAVFAKSAACYNPIVYALSHPKYRSALFTRFPSLACGVGAVEPVVDDDAKSEMSVATTFSDHTSAP* 0

>LMS1_plePay Plexippus paykulli (jumping_spider) Ecdy.Chel.Arac AB251849 18217181 full G? PpRh1 kumopsin1
MLPQAAKMAARASSGVDGKNISIVDLLPEDMLYMIHEHWYKYPPMESTMHYLLGITIILIGIISVS
GNSIVIYLMLSVKSLRTPANFLVTSLAVSDGGMLAFMAPTMPINCFAQTWVLGPFMCELYGMVGSLFGSASIWNMVMITLDRYNVIVRG
MSGKPLTKVGALLRIIFVWVWSLGWTIAPMYGWSSYAPEGSMTGCTVDYLHTDISTMSYLIVY
AIFVYFVPLFIIIYCYTYIVMQVAAHEKSLREQAKKMNIKSLRSNEDNKKASAEFRLAKVALMTICLWFMAWTPYLILSLLGIFSDREWLTPLTSIWGAVFAKAASAYNPIVYGIS
HPKYRAALHEKFPCLNCATESPKGDSASTVAESDKGGD*

>LMS2_plePay Plexippus paykulli (jumping_spider) Ecdy.Chel.Arac AB251850 18217181 full G? PpRh2 kumopsin2
MSSQIINGAYMVSRDALGLHLPTNLGGPLPQDNSYYPYLRNTTVVDTVPKEILHMIHDHWYQFPPLNPLWHSLLGIAMILLGIVSVI
GNGMVMYLMNTTKSLKTPTNMLIVNLAFSDFCMMAFMMPTMAANCFAETWILGPFMCEIYGMAGSLFGCVSIWSMVMIAFDRYNVIVRG
MNAEPLTTKKAAAQIFLIWAWAIMWTVLPFFGWSRYVPEGNM
TSCTVDYLSEDLKSSSYVLIYGCAVYFIPLFTLIYNYTFIVRAVSIHEDNLREQAKKMNVTSLRANADQQKQSAECRLAKIALMTVGLWFIAWTPYLCIAWSGIFSSRKHLTPLAT
IWGAVFAKAVAVYNPIVYGISHPKYRAALFQKFPSLACTTESDVIDNKSEVTFVTDEKPPKTQEA*

>LMS1_hasAda Hasarius adansoni (jumping_spider) Ecdy.Chel.Arac AB251846 18217181 full G? HaRh1 kumopsin1
MLPHAAKMAARVAGDHDGRNISIVDLLPEDMLPMIHEHWYKFPPMETSMHYILGMLIIVIGIISVS
GNGVVMYLMMTVKNLRTPGNFLVLNLALSDFGMLFFMMPTMSINCFAETWVIGPFMCELYGMIGSLFGSASIWSLVMITLDRYNVIVKG
MAGKPLTKVGALLRMLFVWIWSLGWTIAPMYGWSRYVPEGSMTSCTIDYIDTAINPMSYLIAY
AIFVYFVPLFIIIYCYAFIVMQVAAHEKSLREQAKKMNIKSLRSNEDNKKASAEFRLAKVAFMTICCWFMAWTPYLTLSFL
GIFSDRTWLTPMTSVWGAIFAKASACYNPIVYGISHPKYRAALHDKFPCLKCGSDSPKGDSASTVAESEKAGE*

>LMS2_hasAda Hasarius adansoni (jumping_spider) Ecdy.Chel.Arac AB251847 18217181 full G? HaRh2 kumopsin2
MSSHTINSAFMVPRDVLGLHLPNNLGGPLPHDNSYYPYLRNATVVDTVPKEILHMIHDHWYQFAPLNPLWHSLLGIAMIILGIVSVI
GNGMVIYLMSTTKSLKTPTNMLIVNLAFSDFCMMAFMMPTMAANCFAETWILGPLMCEIYGMAGSLFGCVSIWSMVMIAFDRYNVIVRG
MSAEPLTTKKAAAQIFFIWTWATTWTLFPFFGWSRYVPEGNMTSCTVDYLTEDLKSSSYVLIYGCAVYFTPLFTLIYNYTFIVRSVSIHENNLREQAKKM
NVSSLRANADQQKQSAECRLAKIALMTVGLWFIAWTPYLSIAWSGIFSSRKHLTPLATIWGAVFAKAVAVYNPIVYGISHPKYRAALFEKFPSLACTTESDVTDNKSEVTLVTDEKPPKTQEA*

>LMS_limPol Limulus polyphemus (horseshoe_crab) Ecdy.Chel.Mero AY190512S1 14977331 full G? intronated lateral_eye
0 MANQLSYSSLGWPYQPNASVVDTMPKEMLYMIHEHWYAFPPMNPLWYSILGVAMIILGIICVLGNGMVIYLMMTTKSLRTPTNLLVVNLAFSDFCMMAFMMPTMTSNCFAETW
ILGPFMCEVYGMAGSLFGCASIWSMVMITLDRYNVIVRGMAAAPLTHKKATLLLLFVWIWSGGWTILPFFGWSR 2
1 YVPEGNLTSCTVDYLTKDWSSASYVVIYGLA 0
0 VYFLPLITMIYCYFFIVHAVAEHEKQLREQAKKMNVASLRANADQQKQSAECRLAK 0
0 VAMMTVGLWFMAWTPYLIISWAGVFSSGTRLTPLATIWGSVFAKANSCYNPIVYGISHPRYKAALYQRFPSLACGSGESGSDVKSEASATTTMEEKPKIPEA* 0

>LMS_neoOer Neogonodactylus oerstedii (mantis_shrimp) Ecdy.Crus.Mala DQ646869 17053049 full G? Rh1
MSYWNSNKIVEEYSLPSTNPYGNFTVVDTVPENMLHMIHSHWYQFPPLNPMWYGILAFVVTVVGLCSICGNFVVIWVFMNTKALRSPANTLVVSLAVSDFIM
MACMFPPLVLNCYWGTWIFGPLFCEVYAFIGNTVGCASIGNMIFITFDRYNVIVKGISGTPLSQKNTTLQVLFVWICSIMWCVFPFFGWNRYVPRGDMTACGTDYLTEDEFSRSYL
YVYSVWVYIGPLALIIYCYFHIVSAVATHEKQMRDQAKKMGVKSLRTEEAKKTSAECRLAKVALTTVSLWFMAWTPYLIINWAGMFYPSVVSPLFSIWGSVFAKANAVYNPIVYAI
SHPKYRAALYKKLPCLACSTESADEGSATNSATTTTAEKYESA* 0

>LMS_lucCru Luciola cruciata (firefly) Ecdy.Inse.Cole AB300328 19232386 full G?
MSVLGEPSFAAWASQAGVMSSRFGGGNITVVDKVPPDMLHLIDAHWYQYPPLNPLWHAILGFMIGVLGCISVTGNGMVIYIFSTTKSLRSPSNLLVVNLAFS
DFLMMFTMAPPMVINCYNETWVWGPLFCQIYGMLGSLFGCTSIWTMTMIALDRYNVIVKGLSAKPLTKQGALIRIFLVWVFSIGWTIAPVFGWNRYVPEGNMTACGTDYLSTGWFS
RSYILFYSWFVYFIPLFAIIYSYWFIVQAVSAHEKAMREQAKKMNVASLRSSEAAQTSAECKLAKVALMTISLWFLAWTPYLVTNYAGIFDGSKISPLATIWSSLFAKANAVYNPI
VYGISHPKYRQALQKKFPSLVCAAEPDDTVSQTTAATAASEEKAAA* 0

>LMS_triCas Tribolium castaneum (flour_beetle) Ecdy.Inse.Cole ES544655 18342244 full G? 3 exons from AAJJ01000967 5 fusion relative to bee
0 MSVMGEPNFIAWAAQRSGYGGGNLTVVDKVLPDMLHLVDAHWYQFPPMNPLWHGILGFVIGVLGFVSIVGNGMVIYIFSSTKALRTPSNLL
VVNLAFSDFLMMlCMSPAMVINCYNETWVLGPLVCELYGMSGSLFGCASIWTMTFIALDRYNVIVKGLSAQPLTKKGAMLRILIIWVFSTLW
TIAPFFGWNRYVPEGNMTACGTDYLTKDWVSRSYILVYAVWVYFVPLFTIIYSYWFIVQ 0
0 AVAAHEKSMREQAKKMNVASLRSSEAAQTSAECKLAKIALMTITLWFFAWTPYLVTNFTGIFEGAKISPLATIWCSLFAKANAVYNPIVYGIS 2
1 HPKYRQALQKKFPSLVCAGEPDDTTSTASGVTNVTTDEKPATA* 0

>LMS1_droMel Drosophila melanogaster (fruitfly) Ecdy.Inse.Dipt NM_079683 19398933 full G? RH1 ninaE
0 ME 0
0 SFAVAAAQLGPHFAPLSNGSVVDKVTPDMAHLISPYWNQFPAMDPIWAKILTAYMIMIGMISWCGNGVVIYIFATTKSLRTPANLLVINLAISDFGIMITNTPMM
GINLYFETWVLGPMMCDIYAGLGSAFGCSSIWSMCMISLDRYQVIVKGMAGRPMTIPLALGKIAYIWFMSSIWCLAPAFGWSR 2
1 YVPEGNLTSCGIDYLERDWNPRSYLIFYSIFVYYIPLFLICYSYWFIIA 0
0 AVSAHEKAMREQAKKMNVKSLRSSEDAEKSAEGKLAKVALVTITLWFMAWTPYLVINCMGLFKFEGLTPLNTIWGACFAKSAACYNPIVYGIS 2
1 HPKYRLALKEKCPCCVFGKVDDGKSSDAQSQATASEAESKA* 0

>LMS6_droMel Drosophila melanogaster (fruitfly) Ecdy.Inse.Dipt NM_079644 19398933 full G? RH6 gross genomic misassembly exon1
0 MASLHPPSFAYMRDGRNLSLAESVPAEIMHMVDPYWYQWPPLEPMWFGIIGFVIAILGTMSLAGNFIVMYIFTSSKGLRTPSNMFVVNLAFSDFMMMFTMFPPVVLNGFYGT
WIMGPFLCELYGMFGSLFGCVSIWSMTLIAYDRYCVIVKGMARKPLTATAAVLRLMVVWTICGAWALM
PLFGWNRYVPEGNMTACGTDYFAKDWWNRSYIIVYSLWVYLTPLLTIIFSYWHIMK 0
0 AVAAHEKAMREQAKKMNVASLRNSEADKSKAIEIKLAKVALTTISLWFFAWTPYTIINYAGIFESMHLSPLSTICGSVFAKANAVCNPIVYGLS 2
1 HPKYKQVLREKMPCLACGKDDLTSDSRTQATAEISESQA* 0

>LMS_anoGam Anopheles gambiae (mosquito) Ecdy.Inse.Dipt XM_319247 full G? most introns obliterated
0 MPYYGPMQQPGLWGQPVANLTVVDKVPPEIMHLVDPHWSQFPPMNPLWHSIIGFVIFVLGVVSIIGNGMVIYIFSTAKSLRTPSNLFIVNLALSDFLMMGTNAFTMVYNCWFETWSLG
LLMCDLYAFFGSLFGCCSIWTMTMIALDRHNVIVHGLSGKPLTNTGAILRILLCWLIGVVWGILPMLGWNRYVPEGNMTACGTDYLTDDWFHKSYILVYSVFVYYTPLFTIIYAYFFIIK 0
0 AVSAHEKNMREQAKRMNVQSLRSSDDGKSTEMKLAKVALVTISLWFMAWTPYTVINYTGVFKTASITPLATIWGSVFAKANAVYNPIVYGISHPKY
RAALLRRFPSLACSDGPPADDKSLASEASGITSAGNPTTA* 0

>LMS2_droMel Drosophila melanogaster (fruitfly) Ecdy.Inse.Dipt M12896 full G? RH2 CG16740-RA Rh2 ocellar-specific
0 MERSHLPETPFDLAHSGPRFQAQSSGNGSVLDN 0
0 VLPDMAHLVNPYWSRFAPMDPMMSKILGLFTLAIMIISCCGNGVVVYIFGGTKSLRTPANLLVLNLAFSDFCMMASQSPVMIINFYYETWVLGPLWCDIYAGCGSLFGCVSIWSMC
MIAFDRYNVIVKGINGTPMTIKTSIMKILFIWMMAVFWTVMPLIGWSAYVPEGNLTACSIDYMTRMWNPRSYLITYSLFVYYTPLFLICYSYWFIIAAVAAHEKAMREQAKKMNVKSL
RSSEDCDKSAEGKLAKVALTTISLWFMAWTPYLVICYFGLFKIDGLTPLTTIWGATFAKTSAVYNPIVYGIS 2
1 HPKYRIVLKEKCPMCVFGNTDEPKPDAPASDTETTSEADSKA* 0

>LMS_rhoPro Rhodnius prolixus (kissing_bug) Ecdy.Inse.Hemi genomic full G?
0 MAQPIGPSFAAYQWGQSANPSANRSVVDMVPPEMLSMVDAHW 2
1 YQFPPLNPLWHGILGFVIGVLGIISIVGNGMVIFIFSSTKTLRTPSNLLVVNLAFSDFLMMFTMSPPMVINCYNETWVL 1
2 GPLMCELYGMLGSLFGCASIWTMTMIALDRYNVIVK 0
0 GISAKPMTNKTAMLRILLVWAFSIMWTVFPFFGWNR 2
1 YVPEGNMTACGTDYLTKNWVSRSYILVYSVFVYFLPLFTIIYSYFFILQ 0
0 AVSAHEKQMREQAKKMNVASLRSAEAANTSAEAKLAK VALMTISLWFMAWTPYLVINYSGIFETISISPLFTIWGSLFAKANAVYNPIVYAIR 2
1 HPKYKQALEKKFPSLSCASPQDDTTSVATGVTTSTDDKAPSA* 0

>LMS_acyPis Acyrthosiphon pisum (aphid) Ecdy.Inse.Hemi SCAFFOLD6053 full G?
0 MLNKIGSHYERQENWVAEGGFGNETVVDRVPADMMHLIDPSW 2
1 YQFPPMESMWYKWLGVTIFFLGILSVVGNGMVIYIFTCTKNLRTPSNLLIVNLAFSDFCLMFTMCPAMVWNCFYETWMF 1
2 GPFACELYAMFGSLFGVTSIWTMVFIALDRYNVIVK 0
0 GLSAKPMTTKLALLQIFCIYLHGLFWTLTPFFGWSR 2
1 YVPEANMTACGTDYLTLAWHSRSYVLVYAIFAYYLPLLVIIYAYYFIVK 0
0 AVASHEKSMREQAKKMNVSSLRSGDQSNTSAEFKLAKVALMTISLWFMAWTPYMVINFAGIFQLMTIDPLFTIWGSVFAKANAVYNPIVYAIS 2
1 HPKYRLALDKKFPCLVCGKLEDDRSDSKSVASAQTTISEDKV* 0

>LMS_homCoa Homalodisca coagulata (sharpshooter) Ecdy.Inse.Hemi AY588065 full G?
MSLISEPSFSAYSWASQGGFGNQTVVDKVPPEMLYLVDAHWYQFPPMNPLWHSLLGFAMVVLGFIAVTGNGMVVYIFSCTKALRTPSNLLVVNLAFSDFLMM
FTMAPPMVLNCYYETWVLGPFMCELYAMFGSILGCTSIWTMVMIANDRYNVIVKGLSAKPMTIKSALARILFCWAHSLIWCLAPFLGWGRYVPEGNMTACGTDYLTPDWISKSYIL
VYSLFCYFMPLFLIIYSYWFIVQAVSAHEKAMREQAKKMNVASLRSSDAANTSAEHKLAKVALMTISLWFCAWTPYLVINYAGIFQALTISPLFTIWGSVFAKANACYNPIVYAIS
HPKYRAALNKKFPSLVCGATEAPASTSDGASVASGATTLTEDKSAAA*

>LMSa_nasVit Nasonia vitripennis (jewel_wasp) Ecdy.Inse.Hyme XM_001606013 full G? 22063-23541 - strand of AAZX01007316 --
0 MGPSFLTLTAMAQRGGYGGGGGFGGGFNNQTVVDKAPPEIHHMIDPYWYQFPPMNPLWYGILGFVIGCLGCISVAGNGMVVYIFASTKSLRTPSNLLVINLAFSDFCMMFTMSPPM 0
0 VINCYYETWVFGPLMCEIYALCGSIFGCGSIWTMCMIAFDRYNVIVKGLSAKPMTINGSLLRILGIWLMASIWTIAPMFGWNR 2
1 YVPEGNLTACGTDYFSKDWVSRSYIVVYSFFVYFLPLFMIIYSYYFIIKAVSAHEKNMREQAKKMNVASLRQGDSQSAENKLAK 0
0 IALMTISLWFMAWTPYLVINWAGIFDLARLTPLFTIWGSVFAKANAVYNPIVYGIS 2
1 HPKYRAALFARFPSLACAGDAPAGAASDAVSTTSGVTTLTDHDKSNA* 0

>LMSb_nasVit Nasonia vitripennis (jewel_wasp) Ecdy.Inse.Hyme AAZX01007316 full G? tandem pair to LWSa fairly diverged
0 MEHPIVAAGVNATGEFDASSGSASSTTTMVTTAAVQVASTIGPHFARQVMRGFGNLTVVDKVPPEMLHLVGPHW 2
1 YQFPPLWPIWHKLLGVVMIFIGVLGWCGNGMVVYIFLVTPSLRTPSNLLVINLAFSDFVMMIIMSPPMVVNCWYETWIL 1
2 GPLMCDIYALIGSLCGGASIWTMTAIAYDRYNVIVK 0
0 GMSGTPLTIPRALVQIVLIWTHGLIWAMLPLFGWNR 2
1 YVPEGNMTSCGTDYVSDDWLGKSYILVYSIFVYYTPLFSIILCYWHIVS 0
0 AVAAHERGMREQAKKMNVASLRSGDQSGESAEVKLAK 0
0 VAVTTISLWFLAWTPYLVTNYMGIFAKQHVSPLFTIWASLFAKTNACYNPIVYGIS 2
1 HPKYRAGLKVKCPCLVFGDTEDKPKPAAATPAADAASTHSKA* 0

>LMSa_apiMel Apis mellifera (bee) Ecdy.Inse.Hyme NM_001077825 16291092 full Gq rhabdomeric long wavelength ocelli not compound
0 MDTLNITTSFFIEVMPSNISTLTTTGPQFARQLMRFNNQTVVSKVPEEMLHLIDLYW 2
1 YQFPPLDPLWHKILGLVMIILGIMGWCGNGVVVYVFIMTPSLRTPSNLLVVNLAFSDFIMMGFMCPPMVICCFYETWVL 1
2 GSLMCDIYAMVGSLCGCASIWTMTAIALDRYNVIVK 0
0 GMSGTPLTIKRAMLQILGIWLFGLIWTILPLVGWNR 2
1 YVPEGNMTACGTDYLSQDWTFKSYILVYSFFVYYTPLFTIIYSYYFIVS 0
0 AVAAHEKAMKEQAKKMNVTSLRSGDNQNTSAEAKLAK 0
0 VALTTISLWFMAWTPYLVINYIGIFNRSLITPLFTIWGSLFAKANAIYNPIVYGIS 2
1 HPKYRAALKEKLPFLVCGSTEDQTAATAGDKASEN* 0

>LMSa_attCep Atta cephalotes (ant) Ecdy.Inse.Hyme wgs ADTU01020830 16601190 full iMet uncertain 80% bee
0 MAFADVTRTIGPRAMQQIMSFNNKTVVNKVPPDMMHLIDPHW 2
1 YQFPPMNPMWHKILGLVMIVLGFMGWCGNGVVVYIFLMTPSLRTPSNLLIVNLAFSDFIMMIIMTPHMMINCYYETWIL 1
2 GPLMCDMHAMVGSLCGCASIWTMTAIALDRYNVIVK 0
0 GMAGKPLTIKKALLEILIIWLFASIWAILPIVGWNR 2
1 YVPEGNMTACGTDYLTKDWSSKSYILVYSIFVYYMPLLIIIYSYYFIVS 0
0 TVAAHERTMREQAKKMNVQSLRSGDNQNISAEAKLAK 0
0 VALMTISLWFMAWTPYLVINYVGIFGIAKISPLFTIWGSLFAKANAIYNPIVYGIR 2
1 HPKYRAALKEKLPFFVCGSTEDPSVAAKTAETSSTTTT* 0

>LMSb_apiMel Apis mellifera (bee) Ecdy.Inse.Hyme U26026 full G? 5 exonsArthropoda Insecta 540 complete genNow
0 MIAVSGPSYEAFSYGGQARFNNQTVVDKVPPDMLHLIDANWYQYPPLNPMWHGILGFVIGMLGFVSVMGNGMVVYIFLSTKSLRTPSNLFVINLAISDFLMMFCMSPPM 0
0 VINCYYETWVLGPLFCQIYAMLGSLFGCGSIWTMTMIAFDRYNVIVKGLSGKPLSINGALIRIIAIWLFSLGWTIAPMFGWNR 2
1 YVPEGNMTACGTDYFNRGLLSASYLVCYGIWVYFVPLFLIIYSYWFIIQAVAAHEKNMREQAKKMNVASLRSSENQNTSAECKLAK 0
0 VALMTISLWFMAWTPYLVINFSGIFNLVKISPLFTIWGSLFAKANAVYNPIVYGIS 2
1 HPKYRAALFAKFPSLACAAEPSSDAVSTTSGTTTVTDNEKSNA* 0

>LMSb_attCep Atta cephalotes (ant) Ecdy.Inse.Hyme wgs ADTU01020829 18362345 full 78% bee 
0 MSFVSGPSHAAYTWAAQGGGFGNQTVVDKVPPEMLHMVDVHWYQFPPMNPLWHGLLGFAIGVLGTISIIGNGMVIYIFTTTKSLRTPSNLLVVNLAISDFLMMLWMSPAM 0
0 VINCYYETWVLGPLFCELYGMMGSLFGCGSIWTMTMIAFDRYNVIVKGLSAKPMTIKGALIRIFAIWLFTILWTIAPLFGWNR 2
1 YVPEGNMTACGTDYLTKDIVSRSYILFYSIFVYFMPLFLIIYSYFFIIQAVAAHEKNMREQAKKMNVASLRSAENQSTSAECKLAK 0
0 VALMTISLWFMAWTPYLIINFAGIFETTKISPLFTIWGSLFAKANAVYNPIVYGIR 2
1 HPKYRAALFQRFPSLACATEPAPGADTMSTTTTVTEGEKSVA* 0

>LMS_manSex Manduca sexta (moth) Ecdy.Inse.Lepi L78080 full G?
MDPGPGLAALQAWAAKSPAYGAANQTVVDKVPPDMMHMIDPHWYQFPPMNPLWHALLGFTIGVLGFVSISGNGMVIYIFMSTKSLKTPSNLLVVNLAFSDFL
MMCAMSPAMVVNCYYETWVWGPFACELYACAGSLFGCASIWTMTMIAFDRYNVIVKGIAAKPMTSNGALLRILGIWVFSLAWTLLPFFGWNRYVPEGNMTACGTDYLSKSWVSRSY
ILIYSVFVYFLPLLLIIYSYFFIVQAVAAHEKAMREQAKKMNVASLRSSEAANTSAECKLAKVALMTISLWFMAWTPYLVINYTGVFESAPISPLATIWGSLFAKANAVYNPIVYG
ISHPKYQAALYAKFPSLQCQSAPEDAGSVASGTTAVSEEKPAA*

>LMS_bomMor Bombyx mori (moth) Ecdy.Inse.Lepi BAAB01068714 11549248 full G? Bcop boceropsin Bomopsin1 tandem misassembly CK529859 hemocyte larva CK552244 fat body (pupa)
0 MISLDPGPGMAALQAWGGQVAAYGAANQTVVDKVPPDMLHMVDPHW 2
1 YQFPPMNPLWHALLGFTIGVLGFISISGNGMVIYIFMSTK 0
0 SLKTPSNLLVVNLAFSDFLMMCAMSPAMVVNCYNETWVF 1
2 GPFACELYACAGSLFGCASIWTMTMIAFDRYNVIVKGIAAKPMTNNGALLRILGIWAFSLAWTLAPFFGWNR 2
1 YVPEGNMTACGTDYLSKDWFSRSYILIYSVFVYFAPLLLIIYSYFFIVQ 0
0 AVAAHEKAMREQAKKMNVASLRSSEAANTSAECKLAK 0
0 VALMTISLWFMAWTPYLVINYTGVFESAPISPLATIWGSLFAKANAVYNPIVYGIR 2
1 HPKYQAALYARFPSLQCQSAPPDDGGSVASGATAVSEEKPAA* 0

>LMS_papXut Papilio xuthus (butterfly) Ecdy.Inse.Lepi AB007424 9547302 full G? Rh2
MAIANLEPGMGASEAWGGQAAAFGSNQTVVDKVTPDMMHLIDPHWYQFPPMNPMWHGLLGFTIGVLGFISITGNGMVVYIFTSTKSLKTPSNLLVVNLAFSD
FLMMLCMAPPMLINCYYETWVFGPLACELYACAGSLFGSISIWTMTMIAFDRYNVIVKGIAAKPMTINGALLRILGIWLFSLAWTIAPMLGWNRYVPEGNMTACGTDYLSKSWLSR
SYILVYSIFVYYTPLLLIIYSYFFIVQAVAAHEKAMREQAKKMNVASLRSSEAANTSAECKLAKVALMTISLWFMAWTPYLVINYTGVFETAPISPLATIWGSVFAKANAVYNPIV
YGISHPKYRAALYQKFPSLACQPSAEETGSVASGATTACEEKPSA*

>LMS_schGre Schistocerca gregaria (locust) Ecdy.Inse.Orth X80071 full G?
MASASLISEPSFSAYWGGSGGFANQTVVDKVPPEMLYLVDPHWYQFPPMNPLWHGLLGFVIGVLGVISVIGNGMVIYIFSTTKSLRTPSNLLVVNLAFSDFL
MMFTMSAPMGINCYYETWVLGPFMCELYALFGSLFGCGSIWTMTMIALDRYNVIVKGLSAKPMTNKTAMLRILFIWAFSVAWTIMPLFGWNRYVPEGNMTACGTDYLTKDWVSRSY
ILVYSFFVYLLPLGTIIYSYFFILQAVSAHEKQMREQRKKMNVASLRSAEASQTSAECKLAKVALMTISLWFFGWTPYLIINFTGIFETMKISPLLTIWGSLFAKANAVFNPIVYG
ISHPKYRAALEKKFPSLACASSSDDNTSVASGATTVSDEKSEKSASA*

>BCR_limPol Limulus polyphemus (horseshoe_crab) Ecdy.Chel.Mero FJ791252 full G? ventral eye
MSTGSYFIGNSTAPRSSGWWSYDPGLSVRDTAPENIKHLISDHWSKFPAVNPMWHYLLGLIYIVLGIASLTGQSVVLYLFAKTKPLRTPANMLIVNLAFSDF
MMMITQFPVFIINCLGGGAWQLGPLLCEITGFAGGLFGYGSIVTLAVISIDRYNVIVRGFSASPLTHARSAVFILVIWAWTLGWALPPFFGWGRYVPEGILNSCSFDYLTRDWATV
SYIMGCWICEYALPLMVIIYCYIFIVKAVCDHERHLREQAKKMNVASLRSNVDTQKASAEMRIAKVALVNVLLWVVSWTPYAAIAMIGIAGDQMLITPLRSALPALAGKAASVYNP
IVYAISHPKFRLAMQKEIPCCCINEPQPQSDTSSEMSTKTSVATVNGEDSTAGGTTNN*

>BCR_triGra Triops granarius (tadpole_shrimp) Ecdy.Crus.Bran BAG80976 18984904 full G? RhA
MAAYTEAWNASEEILVRMARAVPSVAWGYPAGVSIADLVPSDMKTMVHSHWNKFPPVNPMWHYLLGMVYIILGTVSIAGNSLVISLFTKTKELRTPANMFVVNLAFSDLCMMITQFPMFVYNCFNGGMWLFGPFLCELYA
ATGAVFGLCSICTLACIAFDRYNLIVKGMSGPKMTSKRATILIAFCWAYAIGWSLPPFFGWGRYIPEGILDSCSFDYLTRDSSTKSFGLCLFFFDYVTPLSIIVFAYFHIVRAIFEHEKILREQAKKMNVTSLRSNADQN
AQSAEIRIAKVALINISLWVAMWTPYATIVLQGLLGNQENITPLVSILPALIAKSASIYNPVIYAISHPRYRVALQQKLPWFCIHEEEKKPISDTDSAKTEASSS*

>BCR2_triLon Triops longicaudatus (tadpole_shrimp) Ecdy.Crus.Bran BAG80981 18984904 full G? RhA
MATYTEAWNASEEILVRMVRAAPSVAWGYPTGVSIVDLVPSDMKTMVHSHWSKFPPVNPMWHYLLGLVYIVLGTVSIAGNSLVISLFTKTKELRTPANMFVVNLAFSDLCMMITQFPMFVYNCFNGGMWLFGPFLCELYA
ATGAVFGLCSICTLACIAYDRYNLIVKGMSGPKMTSKRATILIAFCWSYAIGWSLPPFFGWGRYIPEGILDSCSFDYLTRDSSTKSFGLCLFFFDYITPLSIIVFAYFHIVRAIFEHEKILREQAKKMNVTSLRSNADQN
AQSAEIRIAKVALINISLWVAMWTPYATIVLQGLLGNQENITPLVSILPALIAKSASIYNPVIYAISHPRYRIALQQKLPWFCIHEEEKKPISISDTDSAKTETSSS*

>BCR1_triGra Triops granarius (tadpole_shrimp) Ecdy.Crus.Bran AB293431 18984904 full G?
MANASHYEALQQEFNPWALPESFTLYAYAPEDVRAFLHPHWHNFPATHPAIYYLFGLVYLVLGVTSVG
GNYLVLRIFTKFQELRRPSNVLVINLALSDMLLMLTLFPECVYNFLSGGPWRFGDLGCQIHAFCGALFGYNQ
ITTLVFISYDRFNVIVRGMGGTPLTYARVSAMVAFSWLWATGWSVAPLVGWGGYALDGMLGTCSFDYVTR
TWNNRSHILAATAFMWVIPVLIIAGCYWFIVQAVFKHEAELKAQAKKMNVASLRSNADQQQVSAEIRIAK
VAITNVVLWLSAWTPFMVISNLGIWADPQQVTPLVSSLPVLLSKTSCSYNPLVYAISHPKYRECLKTLVPWICIVLPNDRRGGDNVSSSSSRTEASGKAETVDA*

>BCR2_triGra Triops granarius (tadpole_shrimp) Ecdy.Crus.Bran AB293429 18984904 full G?
MSSGVFNSTDPIALARVSAGSNAHQQVGYNILIKTDGLSVRDVAPLDMHHLLHSHWDAYPPADPRIHYLL
GMLYFFLGIAACMGNVLVLHIFGKHKNLRSPTNTLLMNLAFCDLMIFIGLYPEMLGNIFMNDGTWMWGDV
ACRIHAWFGLVFGFGQMQTLMYMSIDRYNVIVKGLSAQPLTYKKVTQWLAQVWIVSLFWGTAPFFGFGNF
ALDGILNTCSFDYFSRDMLSMSYIVSACVWAYVIPLIVIIFCYTFIVRAVFEHEETLRQQAAKMNVTSLR
SSANSEDTSAEFRIAKIAMINVCLWLWAWSPFTIVSFIGIFGNQAIITPYLSSLPVILAKTSSVYNPIVYALSHPRYQAALKEEFAWLCVKTNSGNSGSSDTKSSVTMESSQPA*

>BCR3_triGra Triops granarius (tadpole_shrimp) Ecdy.Crus.Bran AB293432 18984904 full G?
MMHNFSEPRYEAQVVRYGDFAPGVSVRDMAPENVRYMVHLHWEKFPPPDPRVHTALGALYLIMGVMSAVG
NVLVLYIFGKYKSLRSPTNVLVMNLAFCDLGLFVGLYPELLGNIFINNGPWMWGDVACKIHAWCGLAFGF
GQMQTLMFVSMDRYYVIVKGLKAPPLTYWKVSVWLAMVWIVSIFWATSPFFGFGNLSVDGLLNTCSYDYY
TRDLPTVAYIVGSCVHAYVLPLAVIIFCYSYIVQAVFHHERQLREQAAKMNVASLRSSGGKQDEMSAEFR
IAKIALINCCLWLWAWTPFTVISFMGVLHDDQSIINPYVSSLPVLLAKTSAVYNPIVYGLSHPKFQQCLREEFGWNIGLPKKKDNDSKSVTSVETAMT*

>BCR1_triLon Triops longicaudatus (tadpole_shrimp) Ecdy.Crus.Bran AB293434 18984904 full G?
MSSSGFNSTDPIALARVSAGSNAHQQVGYNILIKTDGLSVRDVAPLDMHHLLHSHWDSYPPADPRIHYLL
GMLYFFLGIAACVGNVLVLHIFGKHKNLRSPTNTLLMNLAFCDLMIFIGLYPEMLGNIFMNDGTWMWGDI
ACRLHAWFGLVFGFGQMQTLMYMSIDRYNVIVKGLSAQPLTYKKVTQWLAQVWIVSLFWGTAPFFGFGNF
ALDGILNTCSFDYFTRDMPAMSYIVGACVSAYVIPLIVIIVCYTFIVRAVFEHEETLRQQAAKMNVTSLR
SSASAEDTSAEFRIAKIAMINVCLWLWAWSPFTIVSFIGIFGNQAIITPYLSSLPVILAKTSSVYNPIVYALSHPKYQAALKEEFAWLCVKTNAGNSGSSDTKSSVTMESNQPA*

>BCR2_braKug Branchinella kugenumaensis (fairy_shrimp) Ecdy.Crus.Bran AB293438 18984904 full G? Rhd
MLNNSEPSFAAYSVADGIWYPAGTKQIDGAPADVIAMTHAHWKQFPPSNPAWNYLFGVIYFFLWIVNHI
GNGLVIWIFLKTKSLRTPSNMLIVNLAIADFFMMLTQSPLYIISAFTSRWWIWGHFWCRFYGYTGGITGIA
AIFTMVFIGYDRYNVIVKGMNGTKITKGMAFIMILWTWIYANAFCLPAMLEVWGNFSPEGLLSTCSFDYL
NDNKFHGYFYTMYIFTGAYCVPMLLLMFFYSQIVKAVWAHEASSRAQAKKMNVESLRSNADANAESAEMR
IAKVALTNVLLWVCIWTPYAFVAVTGAFGNRQILTPLVAQLPSLICKMASCLNPLVYAISHPKYRQVLQK
ELPWFCIHEPEDKKSDATSVGSATTTATA*

>BCR3_braKug Branchinella kugenumaensis (fairy_shrimp) Ecdy.Crus.Bran AB293437 18984904 full G?
MLNFSEPRFAAYSVAEGVWYPPGTTQIDGAPADIVALTHAHWKKFPPSNPAWNYLFACLYFFLWVINHI
GNGLVIKIFLKTKSLRTPSNMLIVNLAIADFFMMLTQSPLFIISAFSSRWWIWGHFWCRFYGYTGGITGIA
AIFTLVFIGYDRYNVIVKGMSGKRISKGMAFGMIVWTWVYANVFCLPPMLQVWGDFSPEGMLSTCSFDYL
NENRLHGPIFTGYIFFGAYCVPMFLLFFFYSQIVKAVWAHEAALKAQAKKMNVESLRSNADANAESAEVR
IAKVALTNVLLWICIWTPYAFVAVTGAFGNRQILTPLVAQLPSLICKCASSLNPIVYAISHPKFRQVIQK
DYPWFCIHEPESSADTKSVTSGQTQVAA*

>BCRa_dapPul Daphnia pulex (water_flea) Ecdy.Crus.Bran AB293433 18984904 full G? RhA
0 MSNNLSSGYSSVAYRSEGASVLWGYPPGLSIVDLVPDDMKEFIHPHWNKFPPVNPMWHYL 2
1 LGVIYVILGITSVT 1
2 GNSLVVHLFAKTRDLRTPANMFVINLAFSDLCMMITQFPMFVFNCFNGGVWLFGPLFCELYACTGSIFGLCSICTMAAISYDRYNVIVNGMNRRRMTY 1
2 GRAGGLILFCWIYAIGWSIPPFVGWGKYIPEGILDSCSFDYLTRDTM 0
0 TISFTCCLFAFDYCVPLIIIIFCYYHIVRAIVHHEDALRDQAKKMNVSSLRSNADQKSQSAEIRVAKIAMMNITLWVAAWTPYAAICLQGAVGNQDKITPLVTILPALIAKSASIFNPVVYAISHPKYRL 0
0 ALQKALPWFCIHEKEEKEPPQDRREDSQSIATTNTNSSDVSLP* 0

>BCRa_hemSan Hemigrapsus sanguineus (crab) Ecdy.Crus.Mala D50583 9318091 full G? BcRh1 compound eye R1-R7 blue-green 480nm
MANVTGPQMAFYGSGAATFGYPEGMTVADFVPDRVKHMVLDHWYNYPPVNPMWHYLLGVVYLFLGVISIAGNGLVIYLYMKSQALKTPANMLIVNLALSDLI
MLTTNFPPFCYNCFSGGRWMFSGTYCEIYAALGAITGVCSIWTLCMISFDRYNIICNGFNGPKLTQGKATFMCGLAWVISVGWSLPPFFGWGSYTLEGILDSCSYDYFTRDMNTIT
YNICIFIFDFFLPASVIVFSYVFIVKAIFAHEAAMRAQAKKMNVTNLRSNEAETQRAEIRIAKTALVNVSLWFICWTPYAAITIQGLLGNAEGITPLLTTLPALLAKSCSCYNPFV
YAISHPKFRLAITQHLPWFCVHEKDPNDVEENQSSNTQTQEKS*

>BCRb_hemSan Hemigrapsus sanguineus (crab) Ecdy.Crus.Mala D50584 9318091 full G? BcRh2 compound eye R1-R7 blue-green 480nm
MTNATGPQMAYYGAASMDFGYPEGVSIVDFVRPEIKPYVHQHWYNYPPVNPMWHYLLGVIYLFLGTVSIFGNGLVIYLFNKSAALRTPANILVVNLALSDLI
MLTTNVPFFTYNCFSGGVWMFSPQYCEIYACLGAITGVCSIWLLCMISFDRYNIICNGFNGPKLTTGKAVVFALISWVIAIGCALPPFFGWGNYILEGILDSCSYDYLTQDFNTFS
YNIFIFVFDYFLPAAIIVFSYVFIVKAIFAHEAAMRAQAKKMNVSTLRSNEADAQRAEIRIAKTALVNVSLWFICWTPYALISLKGVMGDTSGITPLVSTLPALLAKSCSCYNPFV
YAISHPKYRLAITQHLPWFCVHETETKSNDDSQSNSTVAQDKA*

>BCR_porPel Portunus pelagicus (sand_crab) Ecdy.Crus.Mala EF110527 19040762 full G? horrible distal frameshifts
MANSTGPQMAFYGSQDMTYGYPEGVSIVDFVRPEIKPYVHQHWYNYPPVNPMWHYLLGVIYLCLGFISIIGNGMVIYLFAKCQALRTPANILVVNLALSDLI
MLTTNVPFFTYNCFNGGVWMFSATYCEIYGCLGAITGVTSTWLLCMISFDRYNIICNGFNGPKLTNGKAIILAFISWAISVGFGIAPLFGWGKYILEGILTSCSYDYLTQDFNTRS
YNIIIFVFDYFLPAAIIIFSYVFIVKAIFAHEAAMRAQAKKMNVTnLRSGEAESQRAEIRIARTALVNVSLWFICwTPYALISLQgvlgdlsginlLVTTLPALLARSCSW*

>RGR1_homSap Homo sapiens (human) Deut.Euth.Euar NM_001012720 18474598 full G? syn(+PCDH21 -LRIT1 -GRID1 -WAPAL) RPE Mueller exon-skipping splice
0 MAETSALPTGFGELEVLAVGMVLLVE 1
2 ALSGLSLNTLTIFSFCKTPELRTPCHLLVLSLALADSGISLNALVAATSSLLR 2
1 RWPYGSDGCQAHGFQGFVTALASICSSAAIAWGRYHHYCT 1
2 RSQLAWNSAVSLVLFVWLSSAFWAALPLLGWGHYDYEPLGTCCTLDYSKGDR 2
1 NFTSFLFTMSFFNFAMPLFITITSYSLMEQKLGKSGHLQ 0
0 VNTTLPARTLLLGWGPYAILYLYAVIADVTSISPKLQM 0
0 VPALIAKMVPTINAINYALGNEMVCRGIWQCLSPQKREKDRTK* 0

>RGR1_ornAna Ornithorhynchus anatinus (platypus) Deut.Prot.Mono genomic frag G? last D in DRY motif Atlantogenata ERY other placentals GRY
0 1
2 ALLGLCLNGLTIASFRKIKELRTPSNLLVVSLALADSGICLNALMAALSSFLR 2
1 HWPYGAEGCRLHGFQGFATALASISLSAAIGWDRYLRHCS 1
2 RSKPQWGTAVSTVLFAWGFSAFWSMMPILGWGQYDYEPLRTCCTLDYSKGDR 2
1 NFTTYLFAVAFFNFVIPLFIMLTSYQSIEQRFKKSGLFK 0
0 LNTRLPTRTLLFCWGPYALLCFYATVENVTFISPKLRM 0
0 IPALIAKTVPVIDAFTYALRNEDYRGGIWQFLTGQKIERVEVENKIK* 0

>RGR1_galGal Gallus gallus (chicken) Deut.Saur.Arch NM_001031216 14985289 full G? syn(+PCDH21 -LRIT1 +CHAT -PARG) retinal ganglia
0 MVTSHPLPEGFTEIEVFAIGTALLVE 1
2 ALLGFCLNGLTIISFRKIKELRTPSNLLVLSIALADCGICINAFIAAFSSFLR 2
1 YWPYGSEGCQIHGFQGFLTALASISSSAAVAWDRYHHYCT 1
2 RSKLQWSTAISMMVFAWLFAAFWATMPLLGWGEYDYEPLRTCCTLDYSKGDR 2
1 NYITFLFALSIFNFMIPGFIMMTAYQSIHQKFKKSGHYK 0
0 FNTGLPLKTLVICWGPYCLLSFYAAIENVMFISPKYRM 0
0 IPAIIAKTVPTVDSFVYALGNENYRGGIWQFLTGQKIEKAEVDSKTK* 0

>RGR1_xenTro Xenopus tropicalis (frog) Deut.Amph.Anur BC135113 full G? retina G protein receptor syn(+PCDH21 -LRIT1 +CHAT -PARG)
0 MVTSYPLPEGFTETEVFAIGTTLLVE 1
2 ALLGLLLNGLTLLSFYKIRELRTPSNLFIISLAVADTGLCLNAFVAAFSSFLR 2
1 YWPYGSEGCQIHGFQGFVAALSSIGSCAAIAWDRYHQYCT 1
2 RSKLHWSTAVSVVFFIWGFSAFWSAMPLFGWGEYDYEPLRTCCTLDYSKGDR 2
1 NYISYLFTMAFFEFLVPLFILMTAYQSIYQKMKKSGQIR 0
0 FNTSMPVKSLVFCWGPYCLLCFYAVIQDATILSPKLRM 0
0 IPALLAKTSPAVNAYVYGLGNENYRGGIWQYLTGQKLEKAETDNKTK* 0

>RGR1_cynPyr Cynops pyrrhogaster (newt) Deut.Amph.Batr FS290827 frag G? 20090923 lens regenerating iris
0  GFTEIEVFGLGTALLIE 1
2 ALLGFILNGLTLLSFYKIRSLRTPHNFLIVSLALADTGVCINAFIAAFSSFLR 2
1 YWPYGSEGCQIHGFQGFVTALSSISSCGVIAWDRYNQYCT 1
2 RTKLQWGTAISLVSFVWAFSAFWSVMPLLGWGQYDYEPLRTCCTLDYTKGDK 2
1 NFISYLFPLAFFEFVIPLFIMLTAYQSVEQKFKKTGQHK 0
0 FNTGLPVKTLVMCWGPYSLLCFYATIENATTISPKIRM 0
0 LPAILAKTAPAINAFLYGMGNESYRGGIWQFlTGQKIEKAEVDNKTK* 0

>RGR1_gasAcu Gasterosteus aculeatus (stickleback) Deut.Acti.Perc genomic full G? syn(+PCDH21 -LRIT1 +CHAT -PARG) retinal ganglia
0 MVSSYPLPDGFTDFDVFSLGSCLLVE 1
2 GLLGILLNAVTIAAFLKVRELRTPSNFLVFSLAVADIGISMNATIAAFSSFLR 2
1 YWPYGSDGCQTHGFQGFVTALASIHFIAAIAWDRYHQYCT 1
2 RTKLQWSSAITLAVFVWLFTAFWSAMPLIGWGEYDYEPLRTCCTLDYTKGDR 2
1 NYVSYLIPMAIFNMAIQVFVVMSSYQSIAQKFKKTGNPR 0
0 FNPNTPLKAMLFCWGPYGILAFYAAVENATLVSTKLRM 0
0 MAPILAKTSPTFNVFLYALGNENYRGGIWQLLTGEKIDVPQIENKSK* 0

>RGR1_calMil Callorhinchus milii (elephantfish) Deut.Chon.Holo genomic frag G? retina G protein receptor
0 EGFTDFEVFGLGTALLVE 1
2 GLVGLLLNGLTLLAFYKIKELRTPSNLLITSLALSDFGISMNAFIAAFSSFLR 2
1 YWPYGSEGCQTHGFHGFLMALASINACAAIAWDRYHQNCS 1
2 RSRLQWSSAITVTVFIWGIAAFWSAMPLLGWGVYDYEPLRTCCTLDYSKGDR 2
1 NFISFFIIMGSFEFIFPIFIMLSSYQSCKSKFKKNGQVK 0
0 FNTGLPVKTLIFCWGPYSLLCFYATIENITILSPKLRM 0
0 * 0

>RGRa_cioInt Ciona intestinalis (tunicate) Deut.Uroc.Tuni AB079882 12687683 full G? Ci-opsin3 syn(PPT1 NOMO2+ FOXC2- FAHD1-) larval photoisomerase
0 MEVNDKRVYGVLMGLL 1
2 GLLTITGYSLLFVIFAKRPDLKKKNKFLLSLATSDLLITVHVFASTIAAFAPQWPFGDLGCQ 0
0 VDAFIGMAPTFISIAGAALIAKDKYYRFCKPKM 1
2 VGRNYSFHVYLTWTMGIIGGALPFIGFGRYGFETDDVTWRTGCLLDFKSISA 2
1 KYSFYIILISTVWFVWPVYKLVSSYMKISTKINKFYP 0
0 LLFVVPVQMAIGLLPYAIYAMVSITIGVSAVPYFCVVINN 0
0 LAAKVFVGSNPFIYIYFDPELRESCKQIFCSPPAPTNDKISEDSKDE* 0

>RGRa_cioSav Ciona savignyi (tunicate) Deut.Uroc.Tuni genomic full G? Ci-opsin3 larval visual cycle photoisomerase
0 MDFSSKRTYGIAMAAL 1
2 GFIAWVGYGLLFVIFAKSPDLKKKNRFLFSLAVSDLLITIHVVASVVASFQSEWPFGSIGCQ 0
0 LDAFIGMAPTFISIAGAALVAKDKYYRICKPKM 1
2 LVGRNYSFSIYANWTLGIIGGLLPFFGFGQYGFETDDLSLRTGCLLDFKTVSA 2
1 KYRFYIVFISLVWFVWPLYKLTSHYIKISAKLDRFHP 0
0 LMFVVPLQMLVSLLPYAIYAMISITVGVSSAPYYLVAVNN 0
0 IAAKVFIGTNPFIYIYFDPELRLACKNLFKYSSTPVQDQIQDKKDE* 0

>RGRb1_cioInt Ciona intestinalis (tunicate) Deut.Uroc.Tuni AB078611 12373590 full G? CiNut entire neural tube
0 MEIDFGFARTVYGVALLLM 1
2 VFITLLGYAVYFGAIWRSKTLQTRHIWLTSLACGDIIMMVHLILESLSSLGMGHRPRQNFECQ 0
0 VGALVGLFSGYVTIASITWIAIDRYYRQCKPEK 1
2 VGVNYCFYVIIVWAMSFLAASGPALGFGAYESAEENTVKCLIDLNKKDT 2
1 NSRLYIILVSAVWFVYPFVKMILYNKKLVQEAKEPQP 0
0 MAFAVPLTFFLCYLPFAIYASLKITVGLPPLNSMVVASIY 0
0 MLPKVISVVNPYLYMRSDPELLAACRHVVGLTDGKKAV* 0

>RGRb2_cioInt Ciona intestinalis (tunicate) Deut.Uroc.Tuni genomic full G? retina G protein receptor
0 MELEFGITRTAYGIAMLMM 1
2 AAVATFGYSVYILAIWSSKKLQTKHIWLTSLACADLLMMVHLFMDGLSSFHQGRRPKGIFECQ 0
0 VSAHMGLFSGFVSIASMTWICIDRYYRKFKPEK 1
2 VGVNYCFYVIIVWAMSFLAASGPALGFGAYESAEENTVKCLIDLENTDM 2
1 NTIKYFVVVGFLFFFYPIFKMIKYNTKFAYKSEEEKA 0
0 VVIAAPVSFVLGYLPYLVYACLKLTIGLPPLNQASIAFL 0
0 YLLPKFISVMNPYMYMRSDPELLRAAKRVVNFDFDQKIE* 0

>RGRb3_cioSav Ciona savignyi (tunicate) Deut.Uroc.Tuni genomic full G? retina G protein receptor
0 MELEFGIIRTAYGIAMLLM 1
2 AVVATFGYSIYLRAIWSSRKLQTRHIWLTSLACADLIMMVHLFMDGLSSFHQGRRPKGNFECQ 0
0 ASALMGLFSGFVSIGSVTWICIDRYYRRYKPEK 1
2 AGLNYCFYVIIVWGLSFLAASGPAMGFGTYESAQENTVKCLIDLDNTDG 2
1 NTIKYFMVIGVLYFFYPIFKMVKYNTLAQATEVEKT 0
0 VVIAAPATFVIGYLPYLSYAILKLTIGLPPVNEAFIAFV 0
0 ILPKFISVLNPYMYMRSDPELLRAAKDVVNFNFYTKMD* 0

>RGR2_danRer Danio rerio (zebrafish) Deut.Acti.Otoc NM_001024436 full G? retina G protein receptor embryonic RPE brain gut embryo PA
0 MASYPLPEGFTDFDMFAFGSALLVG 1
2 GLLGFFLNAISVLAFLRVREMQTPNNFFIFNLAVADLSLNINGLVAAYACYLR 2
1 HWPFGSEGCQLHAFQGMVSILAAISFLGAVAWDRYHQYCT 1
2 KQKMFWSTSITISCLIWILAVFWAAMPLPAIGWGVFDFEPLRTCCTLDYSQGDR 2
1 GYITYMLTITVLYLAFPVLVLQSSYSAIHAYFKKTHHYR 0
0 FNTGLPLKALLFCWGPYVVVCSLACFEDVSVLSPRLRM 0
0 VLPVLAKTSPIFHAVLYAYGNEFYRGGVWQFLTGQKSADKKK* 0

>RGR2_tetNig Tetraodon nigroviridis (pufferfish) Deut.Acti.Perc genomic full G? retina G protein receptor eye
0 MAAYTLPEGFTEFDMFTFGTALLVG 1
2 GVLGFFLNAISIVSFLTVKEMRNPSNFFVFNLALADISLNVNGLIAAYASYLR 2
1 YWPFGQDGCSYHAFHGMISVLASISFMAAIAWDRYHQYCT 1
2 RQKLFWSTTLTMSSIIWILSIFWSAVPLMGWGVYDFEPMRTCCTLDYTRGDR 2
1 DYVTYMLTLVVLYLTFPAATMWSCYDSIYKHFKKVHQHR 0
0 FNTSMPLRVLLVCWGPYVVMCVYACFENVKVVSPKLRM 0
0 LLPVIAKTNPIFNALLYTFGNEFYRGGVWHFLTGHKIVDPVLKKSK* 0

>RGR2_gasAcu Gasterosteus aculeatus (stickleback) Deut.Acti.Perc genomic full G? retina G protein receptor eye
0 MAAFALPEGFTEFDMFTFGSALLVG 1
2 GLIGFFLNAISIASFLRVKEMWNPSNFFVFNLAVADICLNVNGLTAAYASYLR 2
1 YWPFGQDGCTFHAFQGMIAVLASISFMGVIAWDRYHQYCT 1
2 RQKLFWSTTLTMSAIIWILSIFWAAVPLMGWGVYDFEPMRTCCTLDYTKGDR 2
1 DYVTYMLTLVFLYLMFPALTMWSCYDAIHKHFKKIHLHK 0
0 FNTSTPLRVLLMCWGPYVLMCIYACFENVKVVSPKLRM 0
0 LLPVVAkTNPIFNALLYSFGNEFYRGGVWHFLTGQKMVDPVVKKSK* 0

>RGR2_oryLat Oryzias latipes (medaka) Deut.Acti.Perc genomic full G? retina G protein receptor whole embryo
0 MGTHTLPEGFTDFDMFTFGSALLVG 1
2 GLLGFFLNAISILAFLRVKEMRSPSSFLVFNLALADISLNINGLTAAYASYLR 2
1 YWPFGQEGCDYHGFQGMISVLASISFMAAIAWDRYHQYCT 1
2 RQKLFWSTSITISLIIWILSILWSAFPLMGWGVYDFEPMRIGCTLDYTKGDR 2
1 DYITYMLSLVFFYLMFPAFIMLSCYDAIYKHFKKIHYYR 0
0 FNTSLPLRVMLMCWGPYVLMCIYACFENVKLVSPKLRM 0
0 LPVIAKTNPFFNALLYSFGNEFYRGGVWNFLTGQKIVEPDVKKSKQK* 0

>RGR2_pimPro Pimephales promelas (minnow) Deut.Acti.Otoc genomic full G? retina G protein receptor liver brain PA
0 MASYALPEGFSDFDMFAFGSALLVG 1
2 GLLGFFLNLISVLAFLRVREIQTPNNFFIFNLAVADLSLNINGLVAAYASYLR 2
1 YWPFGSEGCQIHGFQGMVSILASISFLGAIAWDRYHLYCT 1
2 KQKMFWSTSGTISALIWILAVFWAALPLPAIGWGVFDFEPMRTCCTLDYTIGDR 2
1 NYISYMLTITVLYLAFPVLIMQSSYNGIYAHFKKTHHFK 0
0 FNTGLPLKMLLFCWGPYVLMCTYACFENASLVSPKLRM 0
0 VLPVLAKTSPIFHAAMYAYGNEFYRGGIWQFLTGQKPADKKK* 0

>PER1_homSap Homo sapiens (human) Deut.Euth.Euar NM_006583 17167409 full G? RRH peropsin syn(-CFI +NOLA1 +EGF -ELOVL6)
0 MLRNNLGNSSDSKNEDGSVFSQTEHNIVATYLIMA 1
2 GMISIISNIIVLGIFIKYKELRTPTNAIIINLAVTDIGVSSIGYPMSAASDLYGSWKFGYAGCQ 0
0 VYAGLNIFFGMASIGLLTVVAVDRYLTICLPDV 1
2 GRRMTTNTYIGLILGAWINGLFWALMPIIGWASYAPDPTGATCTINWRKNDR 2
1 SFVSYTMTVIAINFIVPLTVMFYCYYHVTLSIKHHTTSDCTESLNRDWSDQIDVTK 0
0 MSVIMICMFLVAWSPYSIVCLWASFGDPKKIPPPMAIIAPLFAKSSTFYNPCIYVVANKK 2
1 FRRAMLAMFKCQTHQTMPVTSILPMDVSQNPLASGRI* 0

>PER1_monDom Monodelphis domestica (opossum) Deut.Meta.Dide genomic full G? RRH peropsin syn(-CFI +NOLA1 +EGF -ELOVL6)
0 MFKNNSVKTLAPEKEGPSVFSPIEHKIVAAYLITA 1
2 GVISIVSNVIVLGIFVKYKALRTATNTIIINLAVTDIGVSSIGYPMSAASDLYGSWKFGYDGCQ 0
0 IYAGLNIFFGMASIGLLTAVAIDRYLTICQPDL 1
2 GRMTSYNYTLMILTAWVNGFFWALMPIVGWAGYAPDPTGATCTINWRKNDV 2
1 SFVSYTMTVITINFAMPLGVMFYCYYNVSQKMKQYSPSNCPDHINRDWSNQVAVTK 0
0 MSVVMILMFLLAWSPYSIVCLWASFGDPKEIPPAMAIVAPLFAKSSTFYNPCIYVAANKK 2
1 FRRAISAMIRCQTHQSMPISNALPMN* 0

>PER1_ornAna Ornithorhynchus anatinus (platypus) Deut.Prot.Mono XM_001506366 full G? RRH peropsin
0 MRRNDSANLLESEHHDRSAFSQTDHNIVAAYLITA 1
2 GIMSIVSNVIVLGIFVKFEELRTATNAIIINLAVTDIGVSGIGYPMSAASDLHGSWKFGHAGCQ 0
0 IYAGLNIFFGMSSIGLLTVVAVDRYLTICRPAI 1
2 GRKMTRSNYTAMILAAWMNGFFWASMPLLGWASYASDPTGATCTINWRKNDA 2
1 SFISYTMTVIAVNFAVPLIVMFYCYYNVSKAMRQYPASRVLENLNIDWSEQVDVTK 0
0 MSVVMILMFLMAWSPYSIVCLWSSFGDPKKISPAVAIMAPLFAKSSTFYNPCIYVVANKK 2
1 FRRAMLSMVQCQTHREITITDVLPMNRSRSPH* 0

>PER1_xenTro Xenopus tropicalis (frog) Deut.Amph.Anur genomic full G? RRH peropsin syn(-CFI +NOLA1 +EGF -ELOVL6)
0 METLAEVSTLLPAGTGTVNISDASSEVHSVFSQSEHNIVAAYLITA 1
2 GVISILSNIIVLGIFVKYKELRTATNAIIINLAFTDIGVSGIGYPMSAASDLHGSWKFGYVGCQ 0
0 IYAGLNIFFGMASIGLLTVVAIDRYLTICRPDI 1
2 GRRISGRHYTAMILAAWINAVFWSVMPVVGWSSYAPDPTGATCTINWRKNDV 2
1 SFVSYTMSVVAVNFVVPLMVMFYCYYNVSRTMKGYGSRSSLGGINADWSDQTDVTK 0
0 MSMVMIVMFLVAWSPYSIVCLWSSFGDPRKIPPAMAIIAPLFAKSSTFYNPCIYVIANKK 2
1 FRRAILSMVQCKSRQEVTLDNHFPMNVSQSTLTT* 0

>PER1_gasAcu Gasterosteus aculeatus (stickleback) Deut.Acti.Perc genomic full G? RRH peropsin syn(+GPR68 -GNPDA1 -ENPEP -C14orf100)
0 MGIDPEVNVTDDVTLYGGKSAFTQLEHNIVAGYLITA 1
2 GVISLFSNIVVLLMFWKFKELRTATNFIIINLAFTDIGVAGIGYPMSAASDIHGSWKFGYAGCQ 0
0 IYAALNIFFGMASIGLLTVVAIDRYLTICRPDI 1
2 GQKMTMQSYNLLILAAWLNAVFWSSMPVVGWASYAPDPTGATCTINWRQNDV 2
1 SFISYTMAVIAVNFVLPLSAMFYCYYNVSATVKRYKASNCLDSANIDWSDQMDVTK 0
0 MSIVMIIMFLVAWSPYSIVCLWASFGDPKTIPAPMAIIAPLFAKSSTFYNPCIYVIANKK 2
1 FRRAIIGMVRCQTRQRITINSQVPMTTSQQPLTQ* 0

>PER1_calMil Callorhinchus milii (elephantfish) Deut.Chon.Holo genomic frag G? RRH peropsin
1 LFVSYTMTVIAVNFVVPLSVMFFCYYNVSKTMSRFISSPSPENINLDWSDQLDVTK 0
0 MSVVMIVMFLLAWSPYSIVCLWASFGNPKLIPPAMAIIAPLFAKSSTFYNPCIYVIANKK 2
1 FRKAIMAMICCQNRQEITINHTLPMTISRVPLTE* 0

>PER1_braFlo Branchiostoma floridae (amphioxus) Deut.Ceph.Bran XM_002228504 12435605 full Go RRH peropsin Amphiop1
0 MNASPSSWLPSGELFTDSPENSSEWPWTDGPTDTAWHHHQTVDPVTYGGYLASAVYLTIT 1
2 GLIAFVGNIFAIIVFLTEKEFRKKEHNSFALNLAIADLSVCVFAYPSSTIS 1
2 GYAGEWMLGDVGCTIYGFLCFTFSLTSMVTLCAISVYRYIVICKPQY 1
2 AHLLTHRRTNYVILGIWLYALVFSVPPLFGVNRYTYEPIS 2
1 ITCSLDWNVQHVGETIYTAAVIIIVYVLNVSIMCFCYFNIIFKSANLKFAALASEKTRTAAKKDIWKTSM 0
0 MCLAMVVSFLIAWTPYAVSSTWDILTEEDLPIIATILPTMFAKSSCMMNPIIYSCCNGKFRQAALKTFSK 0
0 VGSSNKQNGQAQVEPRDPGFAVEPAGHQAFQMRVLPSSSAMTL* 0

>PER1_braBel Branchiostoma belcheri (amphioxus) Deut.Ceph.Bran AB050606 12435605 full G? RRH peropsin Amphiop1 introns from braFlo
0 MNASPSSWLSSGEFFTDSPENSSEWPWTDGPTDTTWRHHQSVDSVSYEGYLASAIYITLT 1
2 GLIAFFGNVITITVFLTEKEFRKKQQNGFVLNLAIADLSVCVFAYPSSAIA 1
2 GYAGRWVLGDVGCTIYGFLCFTFALVSMVTLCVISIYRYILICKPQY 1
2 AHLLTHRRTVYVIIGTWLYALVFTVPPLVGVKRYTYEPMQ 2
1 ITCSLDWNVQHPGEKAYIAAVLVIVYVLQVLIMCFCYFNIIFKSANLKFAALASEKTKMAAKKDTWKTSV 0
0 MCLTMVVSFLIAWTPYAVSSTWDILSAEDLPIIATILPSLFAKSSCMMNPIIYACCNTKFRQAAVKSFRK 0
0 LCGMCKQKVPLSTPQVVLAMQRNTEFTSTVEPTGQAFPMRVLPSISATHTAL* 0

>PER2_braFlo Branchiostoma floridae (amphioxus) Deut.Ceph.Bran XM_002209058 12435605 frag G? RRH peropsin Amphiop3
0 MIPTNNNTENNDLEWGLEKEHGVSATIMGVYLTIV 1
2 GLVSTVGNATVVLMFMLKWRQLCRKAPNLLIINLAAVDLCISVFGYPFSASSGFANQWLFSDAICT 0
0 LYGFSCFLLSMVSMHTLCLISAHRYITICRPEH 1
2 ASKLTMTRTILAVVGAWVYGISVAVPPLFGIA 1
2 GYTYESFGLSCTIDFHGTTVADMVYLSILIILCYVINVAVMGTCYFKIIRK 2
1 FSKHRFREVRDVRTSHQHSFERGVTL 0
0 RCILMTLFYLISWTPYTAVAVWTMVGPPPPVQLGMVAALTAKTHCAFNPILYMLMSE 0
0 VYRKLVLRTMCPCCFNKISNKLVRLPADDSKHSGNLDIFTVGYNTRDQAVQINKNAARRFCFVMET 0
0 ASDDLGIDDEVFAGQLGLCSRVKATEPGVEGFGGSEVPQSPSGTESEWSLSLLDFLPKRSSSKTAKASSLSETCSDNTVLSSAARK
MAFLESSHQQSDREVCCIENRQAPEDTKPCKFAIESLGVRLPHKCCTASQVAGAPSRYAGMIETFTDSKGKTKKKAAVSLSEIDVKKP
PPASKTWERRKTSKNTSRGQRVKRTFGKSRKHAYIVDC* 0

>PER2_braBel Branchiostoma belcheri (amphioxus) Deut.Ceph.Bran AB050607 12435605 full G? RRH peropsin Amphiop2 introns from braFlo
0 MIPTNNNTENNDLEWGLEKEHGVSATIMGVYLTIV 1
2 GLVATVGNATVVLMFIMKWRQLCRKAPNLLVINLAAANLCITIFGYPFSASSGYAHQWLFPDAICT 0
0 LYGFSCFLLSMVSMHTLCLISAHRYITICRPEH 1
2 ASKLTMNRTVLAVIGTWLYAIAVAVPPLFNIA 1
2 RYTYEPSGLSCTIDFRVTTVADLVYLGSLIVLCYVIHVAVMATCYFKIIRK 2
1 FSRHRFRQVRDIRTSHQRSFEMGVTM 0
0 RCILMTLFYLLSWTPYTAVCIWTMVGPPPPVVVSMAAALIAKTHCAFNPILYAFMSE 0
0 VYRKLVFRTMCPCCFNRISCKFVGTPTGGSKVSANPDIFTVDYNSRDQAVQINKAPSRRFCFVMET 0
0 SEDLGSDDTGLTGHSGLWRSGAEVEGLGGLQVTQSPSVSGSELSLSLLDFLPPKPSGRAVSAKLPSPPALNSERATCP
ESSQQPSDRPATGLRQYQKGDTTRSSVGDLILTEDDVTNLPPASETWGRKKSENPLSYRQTTRRTFGRSRKHSYIVD* 0

>PER3_braFlo Branchiostoma floridae (amphioxus) Deut.Ceph.Bran AB050610 12435605 full G? RRH peropsin Amphiop3
0 MDIPTETPYGAGDDPAGTGWRWAETDQNGFHKYDHLIVGLYLFVI 1
2 GIIGTVENGITLATFTKFRSLRSPTTMLLVHLAIADLGICIFGYPFSGASSLR 0
0 SHWLFGGVGCQWYGFNGMFFGMANIGLLTCVAVDRYLVICRQDL 1
2 VDKVNYNTYGVMAALGWLFAAFWAALPLVGWAEYSLEPS 1
2 GTACTINWQKNDSLYISYVTSCFILGFALPLAVMMFCYWQ 0
0 ASCFVNKVLKGDISGDLTFPVAVNVDWEYQNHFSK 0
0 MCLAMVAAFVVAWTPYSVLFLFAAFGNPADIPAWITLLPPLIAKSSALYNPIIYIIANRRFRSAIFSMVKGQNPDVE 0
0 TLFARDFRISPIEDTGKEMSSMGNANA* 0

>PER3_braBel Branchiostoma belcheri (amphioxus) Deut.Ceph.Bran AB050610 12435605 full G? RRH peropsin Amphiop3 introns from braFlo
0 MDIPTETPYGAEEDIGESAGWRWTETDKNGFHKYDHLIVGLYLFVI 1
2 GIIGTIENGITLATFSKFRSLRSPTTMLLVHLAIADLGICIFGYPFSGASSLR 0
0 SHWLFGGVGCQWYGFNGMFFGMANIGLLTCVAVDRYLVICRHDL 1
2 VDKVNYNTYGVMAALGWLFAAFWAALPLVGWAEYALEPS 1
2 GTACTINFQKNDSLYISYVTSCFVLGFVVPLAVMAFCYWQ
0 ASCFVSKVLKGDIAGDLTFPVAANVDWEYQNHFSK 0
0 MCLAMVAAFVVAWTPYSVLFLFAAFWNPADIPAWLTLLPPLIAKSSALYNPIIYIIANRRFRNAICSMMKGQDPDVE 0
0 DDEHADEHRVRSIEDNDKEIISMVNLNMTV* 0

>PER2a_strPur Strongylocentrotus purpuratus (sea_urchin) Deut.Echi.Eleu XM_778236 full Go RRH peropsin overshoots iMet spread across tandem
0 MAASVTESSATEAISRLEPEYMVPLTRTGYLLTAIYLTIV 1
2 GSIATVGNITVICVLCRYRTFRKRSINLLLINMAASDLGVSVAGYPLTTVSGYWGRWLFGDVGCQFYAFCVYTLSCSTISTHAAIAVYRYIYIVKTDL 1
2 RPKLTANFTSGVIVVIWVYAFFWTVTPFVGWSSYIYEPFGTSCSVNWVGRTISDISYMVACTIGVYLLQIFIMLYCYIRVAKK 2
1 IRGVDPGRTEEKDAGVVVFGRLRKREAKIDTHVTK 0
0 MCFMMMLTFIVVWAPYAVECLRAAHVHRISALSSVLPTMFAKSSCMVNPIIFLTSSSKFRQDLGKLWSRPSSQDSLQLEER
NKTQRSLYVRHSELGSAHGNDTASVYYEKERIYIGEMRATSIQKEAELLQRDPELLSIASSTNSDVKFVVRDRPKRYTKR
PVKPQGPRGPEMFTASGVTNKGSSTSDSGGQSTSSGTTGSKPKRSGRKASRQYSMKSQSEDTGEIFTLDGSALEMMSLRKL* 0

>PER2b_strPur Strongylocentrotus purpuratus (sea_urchin) Deut.Echi.Eleu XM_778236 17067569 full Go RRH peropsin no cdna inline tandem PER2_strPur
0 MNSFSEESYVTDPTTTQPTLFLTPLSQTGYLLTALYLTLV 1
2 GIVSTIGNITVLCVLCRYGTFRKRSVNILLMNMAVSDLGVSVAGYPLTAISGYRGRWVFADIGCQFSGFCVYALSCSTISTHAVVAIYRYIYIVKPYH 1
2 RPRLSSSTSCLAILCIWTFTLFWTITPFFGWSSYTYEPFGTSCSINWYGKSLGDLTYIICCVVFVFILPIIIMLYCYIGVAKK 2
1 IKGIDPLRTEERDIAVVFGRLRKHETKIDTRVTK 0
0 ICFMMMASFIVVWTPYAVGSIWASKIGKISASASVLPTMFAKSSCMINPIIFLTSSSKFRADLGKLWNRPSSLEHTIRVEERSREQRSFF
VRQSALPDAMVSRSASVYYDKERIYIGEMRAASIQKEADLLHRDPEAISIASSTSSSLQFVLKDRQNRYKKKAGEASKKGSNILHFPYDDTE
GSMINNLMRPRSHSVTSDNISRVFAPSLKRPTKKRSMSHPDIPSTSADIFTVSPTTIKNLQKQ* 0

>PER1a_sacKol Saccoglossus kowalevskii (acornworm) Deut.Hemi.Ente ACQM01133041 full G? RRH peropsin 7 ests + ACQM01133041
0 MVTTDSLANSTDEPVPSILTLQQHYAASVTLLAL 1
2 AVIGTVLSSVNFRMLLSNPDYCSKAGNFFLSLAVTDL 1
2 CVCIFETPFSAFSHHAGFWIFGDTACQLYAFFGIFFGLVNIFMVTFISLDRYWATCSPVE 1
2 VELKSKYYTRMTALGWMVALFWAAAPVFGWSRYaMEPSMASCSIDYMTNDFSYVTYITCLTLTCYVVPIVVMVYCYVKASKNIKYTGKVTEWAHENNATK 0
0 ISRLCVLQLVFCWSLYGFNCMWTVVADDVETLPKMLTVLAPILAKTTPILNSGLYFLHNKKFRGAAVDMFKAKEE* 0

>PER1b_sacKol Saccoglossus kowalevskii (acornworm) Deut.Hemi.Ente ACQM01067921 frag G? RRH peropsin 0 ests
0 1
2 gVLSVIGNSVVLEMFRRYKELLSPSAILLISLALADL 1
2 GLTIFGMSLSCVSSFAGRWLFGKFGCYFHGFAGMLFGLGSIGNLTVISIDRYIITCKRsL 1
2 QWSYRHYYALLAVAWSNALFWSMMPLFGWSSYALEPEGTSCTIDWMNNDNQYISYVSCVTVTCFILPCAVMTYDYLAAYMKMVKAGYTLSEETEKPNND 0
0 MCIALVAAFLLSWFPSATVFLWAAFGNPGNIPLSFTGVADAFTKIPAVFNPVIYVALNPEFRKYFGKTIGCRRKRKKPIAVRLNGSEQNVENTI* 0

>PER1_lotGig Lottia gigantea (limpet) Loph.Moll.Gast genomic full G? retinochrome
0 MTAAEFSSFEHSIVGITYMVI 1
2 GISGTLLSLLVALTFIREKGLFKYGRAWLHISLAIANVGVVGAFPFSGSSSFSGR 2
1 WLYGSGMCTFYGFIGMFFGIAAIGNVFALCVERYLVSKKKDS 1
2 VDKVSNQFYWMITALVWINAFFWGIMPALGWTS 2
1 YDIEPSGTSCTIKWQNYDSGYPSFMAMLSLTCFLIPLPVALICLILSGTDKITEDKEEKTYFREDQLRS 0
0 TCTFLLILALIGWGPYCFICIWALFADTTQVSMLAAVIPPLAAKTMVLLYPVAYCQGNKRFKNAFLGMFIFNESPKQQ* 0

>PER1_aplCal Aplysia californica (sea_slug) Loph.Moll.Gast EB338056 17190607 full G? retinochrome from 8 8k contig to traces
0 MNDDGNALDGAGVDPAATAAHVSTALGFTKFEHASVGALYMLF 1
2 CIVGVTLNLLTALTFYKDTKLTKGSQPWLHILLALANVGVVAPSPFPASSSFSGR 2
1 WLYGSTMCQIYAFEGMFIGIAAIGAVIALCIERYIACQRSGA 1
2 NDTQGWFYGWSITLVLGNALFWAIMPLLGWSR 2
1 YSVEHTGTSCSIDWKNPDESFVSYIMTLEVFSFGIPMMSAFFCLISASPRPQPQGGATAAAGSGQEQQGEDTACKGCFSEDQLRL 0
0 LCYVFIGFVLVGWGPFAYLCTLAVFSDARGISMLAAAIPPLACKAMVSAYPLAYAVVSPRFRQSFLALIGGGEKKKE* 0

>PER1_todPac Todarodes pacificus (squid) Loph.Moll.Ceph genomic 2226795 full G? retinochrome retinochrome 1991 seq dubious before GDPAH
0 MFGNPAMTGLHQFTMWEHYFTGSIYLVL 1
2 GCVVFSLCGMCIIFLARQSPKPRRKYAILIHVLITAMAVNGGDPAHASSSIVGR 2
1 WLYGSVGCQLMGFWGFFGGMSHIWMLFAFAMERYMAVCHREF 1
2 YQQMPSVYYSIIVGLMYTFGTFWATMPLLGWAS 2
1 YGLEVHGTSCTINYSVSDESYQSYVFFLAIFSFIFPMVSGWYAISKAWSGLSAIPDAEKEKDKDILSEEQLTA 0
0 LAGAFILISLISWSGFGYVAIYSALTHGGAQLSHLRGHVPPIMSKTGCALFPLLIFLLTARSLPKSDTKKP* 0

>PER2_patYes Patinopecten yessoensis (scallop) Loph.Moll.Biva AB006455 9287291 full Go retinochrome depolarizing scop2 inner retina layer
0 MPFPLNRTDTALVISPSEFRIIGIFISIC 1
2 CIIGVLGNLLIIIVFAKRRSVRRPINFFVLNLAVSDLIVALLGYPMTAASAFSNR 2
1 WIFDNIGCKIYAFLCFNSGVISIMTHAALSFCRYIIICQYGY 1
2 RKKITQTTVLRTLFSIWSFAMFWTLSPLFGWSSYVIEVVPVSCSVNWYGHGLGDVSYTISVIVAVYVFPLSIIVFSYGMILQEKVCKDSRKNGIRAQQRYTPRFIQDIEQRVTF 0
0 ISFLMMAAFMVAWTPYAIMSALAIGSFNVENSFAALPTLFAKASCAYNPFIYAFTNANFRDTVVEIMAPWTTRRVGVSTLPWPQVTYYPRRRTS
AVNTTDIEFPDDNIFIVNSSVNGPTVKREKIVQRNPINVRLGIKIEPRDSRAATENTFTADFSVI* 0

>PER_hasAda Hasarius adansoni (spider) Ecdy.Chel.Arac AB525082 19960196 full Go peropsin first ecdysozoan peropsin
0 MDDNMSEIALADDMSTLSTQEPSENVYPYVFPLSTHTIVGTYLIII 1
2 GILGTLGNGLVLVTFLRFRVLVTPTTLLLVNLAVSDLGLILFGFPFSASSSLSAK 2
1 WIFGEGGCQWYAFMGFLFGSAHIGTLALLALDRYLIACRISL 1
2 RGKLTFKRYTQMITVVWTYAFFWALMPLLGWGR 2
1 YGLEPSVTTCTIDWQHNDSSYKSFLIVYFVLGFMVPFAIIAVSYIAIARRVGKKSKERPVVRDLWTNERSVTL 0
0 MAFILIVTFFVAWSPYAVLCLWTIFAEPNTVPPFLTLIPPLFAKSSTVVNPLIYFLSNPKLRTAILSTLSCCNEAPIQNIELPDSPERAANNDAI* 0

>PER_ixoSca Ixodes scapularis (tick) Ecdy.Chel.Arac ABJB010816023 frag Go peropsin mRNAs XM_002409761 XM_002435011 embryonated eggs
1 WLFGATGCQAYAFMGFLFGSAHIGTLTLLALDRYLATCRIGF 1
2 RSKPTFKRYFQLLLLVWLYGLFWAVMPLLGWAR 2
1 YGLEPSFQSCTIDWRHNDSSYKSFTLVYFVLGFLVPACIVLVCYRTSAIHIRAPKPKTVRRDVTDDYWASEEMVTV 0
0 MVALIVVTFFFAWTPYAVLCLWAVFADTKSVPHLLAMVPPLFAKTASTINPFIYFLSNPCIRADVLQLLGCRARSSPHMAISSDAVEEERCCQDQA* 0

>NEUR1_homSap Homo sapiens (human) Deut.Euth.Euar NM_181744 14623103 full G? OPN5 neuropsin index sequence
0 MALNHTALPQDERLPHYLRDGDPFASKLSWEADLVAGFYLTII 1
2 GILSTFGNGYVLYMSSRRKKKLRPAEIMTINLAVCDLGIS 1
2 VVGKPFTIISCFCHRWVFGWIGCRWYGWAGFFFGCGSLITMTAVSLDRYLKICYLSY 1
2 GVWLKRKHAYICLAAIWAYASFWTTMPLVGLGDYVPEPFGTSCTLDWWLAQASVGGQVFILNILFFCLLLPTAVIVFSYVKIIAKVKSSSKEVAHFDSRIHSSHVLEMKLTK 0
0 VAMLICAGFLIAWIPYAVVSVWSAFGRPDSIPIQLSVVPTLLAKSAAMYNPIIYQVIDYKFACCQTGGLKATKKKSLEGFR 2
1 LHTVTTVRKSSAVLEIHEEV* 0

>NEUR1_calJac Callithrix jacchus (marmoset) Deut.Euth.Euar genomic full G? OPN5 neuropsin
0 MALNHTSLPQDERLPHYLRDGDPFASKLSWEADLVAGFYLTII 1
2 GILSTFGNGYVLYMSSRRKKKLRPAEIMTINLAVCDLGIS 1
2 VVGKPFTIISCFCHRWVFGWIGCRWYGWAGFFFGCGSLITMTAVSLDRYLKICYLSY 1
2 GVWLKRKHAYICLAAIWAYASFWTTMPLVGLGDYAPEPFGTSCTLDWWLAQASVGGQVFILNILFFCLLLPTAVIVFSYVKIIAKVKSSSKEVAHFDSRIHSSHVLEMKLTK 0
0 VAMLICAGFLIAWIPYAVVSVWSAFGRPDSIPIQLSVVPTLLAKSAAMYNPIIYQVIDYKFACCQTGGLKATKKKSLEDFR 2
1 LHTVTTVRKSSAVLEIHEEV* 0

>NEUR1_musMus Mus musculus (mouse) Deut.Euth.Euar genomic full G? OPN5 neuropsin
0 MALNHTALPQDERLPHYLRDEDPFASKLSWEADLVAGFYLTII 1
2 GILSTFGNGYVLYMSSRRKKKLRPAEIMTINLAVCDLGIS 1
2 VVGKPFTIISCFCHRWVFGWFGCRWYGWAGFFFGCGSLITMTAVSLDRYLKICYLSY 1
2 GVWLKRKHAYICLAVIWAYASFWTTMPLVGLGDYAPEPFGTSCTLDWWLAQASGGGQVFILSILFFCLLLPTAVIVFSYAKIIAKVKSSSKEVAHFDSRIHSSHVLEVKLTK 0
0 VAMLICAGFLIAWIPYAVVSVWSAFGRPDSIPIQLSVVPTLLAKSAAMYNPIIYQVIDYRFACCQAGGLRGTKKKSLEDFR 2
1 LHTVTTVRKSSAVLEIHQEV* 0

>NEUR1_ochPri Ochotona princeps (pika) Deut.Euth.Euar genomic full G? OPN5 neuropsin
0 MALNDTALPQDEHLPHYFRDGDPFASKLSWEADLVAGFYLTII 1
2 GILSTFGNGYVLYMSSRRKKKLRPAEIMTINLAVCDLGIS 1
2 VVGKPFTIISCFCHRWVFGWIGCRLYGWADFFFGCGSLITMTAVSLDRYLK 1
2 GVWLKRRHAYICLAVIWAYASFWTTMPLVGLGDYAPEPFGTSCTLDWWLAQASVGGQVFILNILFFCLLLPTAVIVFSYVKIIAKVKSSSKEVAHFDSRIHGSHVLEMKLTK 0
0 VAMLICAGFLIAWIPYAVVSVWSAFGRPDSIPIQLSVVPTLLAKSAAMYNPIIYQVIDYKFSCCRTGGLKQTKKKSLEDFR 2
1 LHTVTTVRKSSAVLEIHQEv* 0

>NEUR1_canFam Canis familiaris (dog) Deut.Euth.Laur genomic full G? OPN5 neuropsin
0 MALNHTARPQDERLPHYLREGDPFASKLSWEADLVAGFYLTII 1
2 GILSTFGNGYVLYMSSRRKKKLRPAEIMTINLAICDLGIS 1
2 VVGKPFTIISCFCHRWVFGWIGCRWYGWAGFFFGCGSLITMTAVSLDRYLKICYLSY 1
2 GVWLKRKHAYICLAVIWAYASFWTTMPLVGLGDYAPEPFGTSCTLDWWLAQASLGGQIFILNILFFCLLLPTAVIVFSYVKIIAKVKSSSKEVAHFDSRIHSSHVLEMKLTK 0
0 VAMLICAGFLIAWIPYAVVSVWSAFGRPDSIPIQLSVVPTLLAKSAAMYNPIIYQVIDYKFACCQTGRLKATKKKSLEDFR 2
1 LNTVTTVRKSSAVLEIhQEV* 0

>NEUR1_bosTau Bos taurus (cow) Deut.Euth.Laur genomic full G? OPN5 neuropsin
0 MALNHTAPPPDERRPPYLRDGDPFASKLSWEADLVAGFYLTII 1
2 GILSTFGNGYVLYMSSRRKKKLRPAEIMTVNLAICDLGIS 1
2 VVGKPFTIISCFCHRWVFGWIGCRWYGWAGFFFGCGSLITMTAVSLDRYLKICYLSY 1
2 GIWLKRKHAYICLAVIWAYAAFWTTMPLVGLGDYAPEPFGTSCTLDWWLAQASVGGQIFILNILFFCLLLPTAVIVFSYVKIIAKVKSSSKEVAHFDSRIHSSHVLEVKLTK 0
0 VAMLICAGFLIAWIPYAVVSVWSAFGRPDSIPIQLSVVPTLLAKSAAMYNPIIYQVIDYKFACCQTGGLKATKKKSLEDFR 2
1 LHTVTTVRKSSAVLEVHQEv* 0

>NEUR1_loxAfr Loxodonta africana (elephant) Deut.Euth.Afro genomic full G? OPN5 neuropsin
0 MTLNHTAPPQDDRLPQYLQDGDPFTSKLSWEADLVAGFYLTII 1
2 GILSTFGNGYVLYMSCRRKKKLRPAEIMTINLAVCDLGIS 1
2 VVGKPFVIISCFCHRWVFGWIGCRWYGWAGFFFGCGSLITMTAVSLDRYLKICYLSY 1
2 GVWLKRKHAYICLAVIWAYASFWTTMPLVGLGDYAPEPFGTSCTLDWWLAQASVGGQIFILNILFFCLLLPTAVIVFSYVKIIAKVKSSSKEIAHFDSRIHSSHMLEMKLTK 0
0 VAMLICAGFLIAWIPYAVVSVWSAFGRPDSIPIQLSVVPTLLAKSAAMYNPIIYQVIDYKFACCQTGGLRATKKKSLEGFR 2
1 LHTVTTVKKSSAVLEVHQEv* 0

>NEUR1_dasNov Dasypus novemcinctus (armadillo) Deut.Euth.Xena genomic full G? OPN5 neuropsin
0 MALNHTALPQDDRLPHYLRDGDPFASKLSWEADLVAGFYLTII 1
2 gILSTFGNGYVLYMSSKRKKKLRPAEIMTINLAVCDLGIS 1
2 VVGKPFTIISCFCHRWVFGWIGCRWYGWAGFFFGCGSLITMTAVSLDRYLKICYLSY 1
2 GVWLKRKHAYICLAVIWAYASFWTTMPLVGLGDYVPEPFGTSCTLDWWLAQASVGGQVFILNILFFCLLLPTAVIVFSYVKIIAKVKSSSKEVAHFDSRIHSSHVLEMKLTK 0
0 VAMLICAGFLIAWIPYAVVSVWSAFGRPDSIPIQLSVVPTLLAKSAAMYNPIIYQVIDYKFACCQTGGLRATKKKSLEDFR 2
1 LHTVTTVRESSAVLEVHQEV* 0

>NEUR1_monDom Monodelphis domesticus (opossum) Deut.Meta.Dide genomic full G? OPN5 neuropsin
0 MALNHSVSPQDDYIPHYLRDGDPFASKLSWEADLVAGFYLTII 1
2 GVLSTLGNGYVIYMSSKRKKKLRPAEIMTVNLAVCDLGIS 1
2 VVGKPFTIISCFSHRWVFGWVGCRWYGWAGFFFGCGSLITMTAVSLDRYLKICHLSY 1
2 GTWLKRHHAFICLALIWAYATFWATVPFAGVGSYAPEPFGTSCTLDWWLAQASVAGQAFVLSILFFCLLFPTAVIVFSYVKIILKVKSSTKEVAHYDTRIQNSHILEMKLTK 0
0 VAMLICAGFLIAWIPYAVVSVWSAFGQPDSIPVQFSVVPTLLAKSAAMYNPIIYQVIDCKFACCQSGGQKAAKKESLRTYR 2
1 LHTVTTVRRSSAVLEIHQEv* 0

>NEUR1_ornAna Ornithorhynchus anatinus (platypus) Deut.Prot.Mono genomic full G? OPN5 neuropsin
0 MTNYSAPQLGDYLPHYLREGDPFVSKLSWEADLVAGVYLVII 1
2 GVLSTLGNGYVIYMSSRRKKKLRPAEIMTVNLAVCDLGIS 1
2 VVGKPFTIVSCFCHRWVFGWMGCRWYGWAGFFFGCGSLITMTAVSLDRYLKICHLSY 1
2 GTWLKRHHAYICLAIIWAYASFWATMPLVGLGNYAPEPFGTSCTLDWWLAQASVAGQAFILNILFFCLLLPTAVIVFSYVKIIAKVKSSTKEVAHFDSRIQNSHVLEMKLTK 0
0 VAMLICAGFLIAWIPYAVVSVWSAFGQPDSIPIQFSVVPTLLAKSAAMYNPIIYQVIDCRISCCRLGGPKTGKKESLKNSR 2
1 SHSMSTIRKPSAVSGPHQEV* 0

>NEUR1_galGal Gallus gallus (chicken) Deut.Saur.Arch genomic full G? OPN5 neuropsin
0 MASDCNSSSQEEYLPHYMQQEDPFASKLSREADIIAGFYLTVI 1
2 GILSTLGNGYVIFMSSKRKKKLRPAEIMTVNLAVCDLGIS 1
2 VVGKPFSIISFFSHRWIFGWMGCRWYGWAGFFFGCGSLITMTAVSLDRYLKICHLAY 1
2 GTWLKRHHAFICLALIWAYATFWATVPFAGVGSYAPEPFGTSCTLDWWLAQASVAGQAFVLSILFFCLLFPTAVIVFSYVKIILKVKSSTKEVAHYDTRIQNSHILEMKLTK 0
0 VAMLICAGFLIAWIPYAVVSVWSAFGQPDSVPIQFSVVPTLLAKSAAMYNPIIYQVIDCKFACCRSGGPKTLQKKSSLKESR 2
1 MYTISSHRDSAALSGTQLEV* 0

>NEUR1_xenTro Xenopus tropicalis (frog) Deut.Amph.Anur genomic full G? OPN5 neuropsin
0 MAGNSSYREESGYIPHYERDSDPFASKLSREADIFAGVYLMAI 1
2 GILSTLGNGYVIYMACSRKKKLRPAEIMTINLAVCDLGIS 1
2 VTGKPFAIVSCFSHRWVFGWNACRWYGWAGFFFGCGSLITLTVVSLDRYLKICHLRY 1
2 GTWLKRRHAFIALAVIWAYATLWATLPLVGVGNYAPEPFGTTCTLDWWLAQASVKGQIFVLSMLFFCLLFPTMVIVFSYAKIIAKVKSSAKEVAHFDTRNQNNHTLEIKLTK 0
0 VAMLICAGFLIAWFPYAVVSVWSAFGQPDSIPIELSVVPTMMAKSASMYNPIIYQVIDCKPACCKKDKSLQNTTSR 2
1 VYTISTFRKSTTSAR* 0

>NEUR1_danRer Danio rerio (zebrafish) Deut.Acti.Otoc genomic frag G? OPN5 neuropsin
0 MENETSISSGYIPHYLLRGDPFASKLSKEADIVAAFYILVI 1
2 GILSATGNGYVMYMTFKRKTKLKPPEIMTLNLAIFDFGIS 1
2 VSGKPFFIVSSFSHRWLFGWQGCRYYGWAGFFFGCGSLITMTIVSFDRYLKICHLRY 1
2 gTWLKRHHAFLSVVFIWAYAAFWATMPVVGWGNYAPEPFGTSCTLDWWLTQASVSGQSFVMCMLFFCLIFPTVIIVFSYVMIIFKVKSSAKEVSHFDTRNKNNHSLEMKLTK 0
0 VAMLICAGFLIAWIPYAVVSVM

>NEUR1_calMil Callorhinchus milii (elephantfish) Deut.Chon.Holo genomic frag G? OPN5 neuropsin
0 MTAFDNSTALYSGYWLHDSLHGDPFVSKLSWEADIISACYLIVT 1
2 GLLSTLGNGYVIYLSITQKRKLKPPEILITNLAISDFGMS 1
2 VGGQPFLIISCFSHRWIFGWVGCRWHGWAGFFFGCGSLITMTVVSLDRYLKICHLQY 1
2 GSWLQRRHVFMSLAFIWFYAAFWATMPLVGWGNYAPEPFGTSCTLDWWLARVSVSGLIFVLTILFFCLLLPIIIIVFSYIKIIAKVKSSAKEVAHFDSRIQNHHSLEMNLTK 0

>NEUR1_petMar Petromyzon marinus (lamprey) Deut.Agna.Hype genomic frag G? OPN5 neuropsin
0 VAMMICAGFLLAWIPYAVVSVWSAFGAPDSVPVAVSMVPTMFAKSAAMYNPLIYQLLSRRGTGAHCCRCRKARGTLRRPR 2

>NEUR1a_braFlo Branchiostoma floridae (amphioxus) Deut.Ceph.Bran FE548698 frag G? OPN5 neuropsinframeshifted cDNA FE548698 last exons missing
0 MATTPADRLDGLTPAGRGATTAETHADDFASKLSREADIVIGVYLILI 1
2 GTGAILGNGRVLWLSYRCRARLRPVEMFVVSLAVADVGLSLVGHPFAAASSLMGRWSFGSAGCTW 1
2 YGFVVFFLGIASIASMTLMSIMRFMIVYKRYP 1
2 GQYPTRRASCVLVTAAWLYGLFWACAPLA 1
2 GWSQYQPEPYGLSCSVDWGGFSSDAGGSSFIICMLLFCTAVPVVIMVTSYAAIFVIYRQAQKGVVLNLQVNATFGGKRQRTERKLTL 0
0 IALAVCGGFLLAWLPYAVVGLWASVAGVDAVPLALASAAPLFAKSNSLWNPIIYLGMNERFR 2

>NEUR1b_braFlo Branchiostoma floridae (amphioxus) Deut.Ceph.Bran XM_002202511 full G? OPN5 neuropsin from tracesseparate allele
0 MATTPGLPLDGLAPTGRGVTAADTLDDDFASKLSREADIVIGVYLLLI 1
2 GTGSILGNGRVLWLSYRNWAKLRPVELFVVSLAVTDVGISVFGYPFAASSSLLGRWSFGSAGCTW 1
2 YGFTGFFFGLTSIANMALMSIMRFMIVYKGYP 1
2 GPYPSRRATSGLIAAAWLYGLFWACAPLA 1
2 GWSQYHVEPFGLSCTVDWGSFSRDAGGMSFIICLLVFCVAIPVTAIMASYVAISAIYRQAKKSIAGHLQDNSAMCKKRNKLERSITL 0
0 MALAVCGGFLLAWLPYAVVGLWSAVAGVDAVPLALASAAPLFAKSSSLWNPIIYLGMNDRFS 2
1 AELSREHSYLPATGVRTTGPPAEDNQAEGDDVSSPSLLFFRRLFWTSKT 1
2 SNAMRTLVVLTWISTIFPLLLAAPQADPRTTYKVSRWDEAWRPQRFGRSGRGDTKDGWRPQRFGRGRYEQGWRPQRFGRNEGLAGLREVLDGEAFPLLQMTR
TDLHHDLPGIGYTPGTAHGSLRALPLLRLYDRGALQLINGAAKQSSTNPPSLRMIRAAAESLQGFARGGDQQDEEEMFAPPRSTDDWLAEIQRLGLRGRKRRDVS* 0

>NEUR_strPur Strongylocentrotus purpuratus (sea_urchin) Deut.Echi.Eleu XM_001197837 full G? CX694910 CX690664
0 MDVNAKWWTNETLRTRDQFSDDHYTSVLSYEGDIWAGVYLMFI 1
2 SLIAFIGNISVIVISLRKREKLKPIDLLTINLAIADFLICVVSYPLPMISAFRHR 0
0 WSFGKFGCVWYGFTSFLFAVGSMATLMVIALLRYAKLCRENV 1
2 DQYQSRPFVIKVIVAIWGFAFFTTAPPLFGWS 2
1 SYVPEPYHLSCTIDFADTSPSGLSYTYFTTIVVFFMPLMIIVLCYVAIARKMIHHNRRINVGHNAGRMLLEIRLLK 0
0 TACMITMAYTISWTPYAVIAMWVTYIPVNQIPDAFRILPAFCAKTSSVYNPIIYCIFNKSFRQDLSSLICCCACQCYTITINLDINSHAQQQFRRIEERR
DEVGTYKRRPLMICSNPFAWSRDFHETWRQRRIRGIHRNCRNNVRVENINVNFRRDTDMVELNAPTPAEIHRPELNTASTRSGARTKSMATHLPALEEVPSG
APQCSALLHNTPIPRSLQGTPLPYQPQPSTSDLHDEFLNPSVVSRNMCVIVVKPNIEEELSTD* 0

>NEUR2_galGal Gallus gallus (chicken) Deut.Saur.Arch AB368181 18570255 full G? cOpn5L1 syn(-B4GALT6 -NEUR2_galGal -KIAA1012) GenBank 5'UTR error
0 MDPSFANSTFQSKITEAADIVVGTCYMVF 1
2 GICSLCGNSILLYISYKKKHLLKPAEYFIINLAISDLAMTLTLYPLAVTSSLSHR 2
1 WLYGKHICLFYAFCGLFFGICSLSTLTLLSVVCCLKICFPAY 1
2 GNRFRRKHGQILIACAWTYAAIFACSPLAHWGEYGEEPYGTACCIDWQSTNVDVMSMSYTVVLFVLCFILPCGVIVTSYSLILVTVKESRKAVEQHVSGPTRINNVQTITAK 0
0 LSIAVCIGFFAAWSPYAIIAMWAAFGSIDKIPPLAFAIPAVFAKSSTLYNPIIHLLLKPNFRSNIAKDFTVIQQLCVRCCFCVKELQTYRSTFNTGLRTFKGKNESSCNALPIMEG
CSYFPSEKGSHTFECFKSYPNCFQERLSTMGCHLQDCESLENDLQVEVTQGSRNSMKVVEQEEKSTELDNLEITLEAVPVSCTFTDL* 0

>NEUR2_anoCar Anolis carolinensis (lizard) Deut.Saur.Lepi genomic full G?
0 MESYFANTTFHSKITEAADVIVGVFYIVF 1
2 GICSFCGNSILLYVSYKKKNLLKPAEYFMINLAISDLGMTLTLYPLAVTSSLAHR 2
1 WLFGQQVCLFYAFCGVFFGVCSLTTLTLLSIVCCLKICFPVY 1
2 GNRFRPGHGWILIACAWVYAAIFAFSPLAHWGEYGAEPYGTACCIDWRISNMKKTAMSYTTALFVFCYIIPCGIIITSYTLILITVKDSRKAVEQHALGPTRMSSVHTITAK 0
0 LSIAVCIGFFVAWSPYAIIAMWAAFGSIDMIPPLAFAVPAVFAKSSTLYNPAMYLFLKPNFRSTIAKDLTVLHRLCLKSCFCPRGMQNCSYRSALEAPLKSFKGRNESSSNSVQIVGGCS
YFPCEKCHDPFECFKNYPKCCQGRLNVMDHTPRESISVENNMQSKTKHASEKYIKVVIRGEKNTDIDNLEITLEHIPTDIKFANL* 0

>NEUR2_xenTro Xenopus tropicalis (frog) Deut.Amph.Anur genomic full G? abundant transcripts
0 MGNKSDASAFYSSISETDDIVLGVLYSVF 1
2 GLLSLSGNSMLLLVAYRKRSILKPAEFFIVNLSISDLGMTGTLFPLAIPSLFAHR 2
1 WLFDKVTCNYYAFCGMLFGLCSLTNLTVLSSVCCLKVCYPAY 1
2 GNKFSTAHSRILLLGIWAYAGLFATAPLADWGKYGPEPYGTACCLDWEASYRERKALSYTISLFVFCYLIPSSLIFISYTLIFVTVKGARRAVQQHLSPQAKGSSIHSLIIK 0
0 LSIAVCIGFLIAWTPYAIVAMMAAFGDPTKIPSLVFALAAAFAKSSTIYNPVVYLLLKPNFLNVVTKDLTLFQTMCAVVCGWCRTPAVKTPCPHKD
LKTTSKPPSSFKKSQGVCRNCVDTFECFRNYPRCCSVGNVDAAQPMAASLVRIPPANGAPQQTVQLVVSSSRTRSGVETVEVSTEAPMSDFIKDFI* 0

>NEUR2_danRer Danio rerio (zebrafish) Deut.Acti.Otoc genomic full G? acquired new intron
0 MGNVSKTALFMSTISRQHDILMGSLYSVF 1
2 FVLSLLGNGMLLFVAYRKRSSLKPAEFFVVNLSVSDLGMTLSLFPLAIPSALAHR 2
1 WLFGEITCLCYAVCGVLFGLCSLTNLTALSSVCCLKVCFPNY 1
2 GNKFSSSHACVMVIGVWCYASVFAVGPLVHWGSFGPEPYGTACCINW 2
1 YTPSHDALAMSYIISLFIFCYVVPCTIIILSYTFILVTVRGSQQAVQQHVSPQTKVTNAHALIVK 0
0 LSVAVCIGFLTAWSPYAIVAMWAAFSANEQVPPTAFALAAIMAKSSTIYNPMVYLLFKPNFRKSLSQDTQMFRHRICLSHSKASPSPGMKDQERQS
SQQCNNKDGSISTPFSSGQAESYGACHVYAEAGPHYQQISRQITARVLEGSVQSEIPVKQLTEKMQNDLL* 0

>NEUR2_calMil Callorhinchus milii (elephantfish) Deut.Chon.Holo genomic frag G? novel paralog of neuropsin
0 1
2 GILSLVGNSVLLFVAYRKRQILKPAEYFVANLAVSDISMTVTLLPLAISSNFSHR 2
1 WLFVSKpCMYYGFCSMLFGICSLTNLTVLSTVCCMKVCFPAY 1
2 0
0 MSVVMIVMFLLAWSPYSIVCLWASFGNPKLIPPAMAIIAPLFAKSSTFYNPCIYVISYTMTVIAVNFVVPLSVMFFCYYNV

>NEUR3_galGal Gallus gallus (chicken) Deut.Saur.Arch AB368183 18570255 full G? cOpn5L2 testis exon 2 fused exon 3 rel NEUR1/2
0 MEEQYISKLHPVVDYGAGVFLLII 1
2 AILTILGNSAVLATAVKRSSLLKSPELLTVNLAVADIGMAISMYPLAIASAWNHAWLGGDASCIYYALMGFLFGVCSMMTLCAMAVIRFLVTNSSKSN 1
2 SNKISKNTVHILITFIWLYSLLWAILPLVGWGYYGPEPFGISCTIAWSKFHSSSNGFSFILSMFLLCTVLPALTIVACYLGIAWKVHKAYQEIQNINRIPHAAKLEKKLTL 0
0 MAVLISVGFLSAWTPYAAASFWSIFNSSDSLQPIVTLLPCLFAKSSTAYNPFIYYIFSKTFRHEIKQLQCCWGWRVHFFSADNSAENSVSMMWSGRDNIRLSPTAKVESQGAARH* 0

>NEUR3_taeGut Taeniopygia guttata (finch) Deut.Saur.Arch ABQF01025032 full G?
0 MEEQYISKLHPVVDYGAGVFLLII 1
2 AILTILGNSAVLATAVKRSSLLKPPELLTVNLAVADIGMALSMYPLAIASAWSHAWLGGDASCVYYALMGFLLGVCSMMTLCAMAVIRFLVTNSPKSN 1
2 sNKITKNTVCILIAFIWLYSLLWAILPLVGWGYYGPEPFGISCTIAWSKFHNSSNGFSFILSMFLLCTVLPALTIVACYLGIAWKVHKAYQEIQNIDRIPNAAKLEKKLTL 0
0 MAVLISVGFLSSWTPYAATSFWSIFNSSHSLQPVVTLLPCLFAKSSTAYNPFIYYVFSKTFRCEVKRLQCCCAWRVHYFSSDNSVENPLSTMWSGRDNIRLSAAPQVQNPGAAAP* 0

>NEUR3_anoCar Anolis carolinensis (lizard) Deut.Saur.Lepi AAWZ01001057 full G?
0 MEEHYISKVHPVWDYGMGVFLLII 1
2 AILTILGNSMVLAVAVKRSSCLRSPELLTVNLAATDLGMGLSMYPLAIASAWNHAWLGGEATCIYYALMGFLFGVSSIMTLSAMAVIRFLVTFSSKPA 1
2 GHKINRKVMHICIMLIWAYAVLWAILPLLGWGHYGPEPFGTSCTIAWGQFHNSQKGFAFILSMFILCTFLPAITIIMCYLGIAWKFHKTHQEMQNLNRISSAAKLEKKLIL 0
0 VAVLISVGFLGAWTPYAIVSFWSVFHSSESIPYIVTLLPCLFAKSSTAYNPFIYYTFSKTFRHEVKHLRCYSGQRAQENMKNSINSNVSFMWHGGGNICLSTRQIEMREIPNQ* 0

>NEUR3_xenTro Xenopus tropicalis (frog) Deut.Amph.Anur genomic full G? cdna ovary embryo
0 MEERYLSKLHPLVDFGSGVFLLLV 1
2 AILTVLGNCAVLATAVKCSSHLKAPDLLSINLAVADLGMAISMYPLAIASAWNHAWLGGDASCLYYALMGFFFGVSSMMTLTVMAIIRYRVTSSFKYS 1
2 GCTIEKKAVCILIMCIWLYALLWAVLPLLGWGRYGPEPFGTSCTIAWGDFHHSSNGFSFIISMFILCTISPAVTIVVCYSGIAWKLHKAYQEIKNQDKIPNSTKVEKKLTL 0
0 LAILVSFGFLISWTPYAAVSFWSLFHSSKYIPPVVSLLPCLFAKSSTAFNPMIYYAFSKTFRRKVKHLKCCCGWRVHFLQSENSVENPRVSVIWTGKENVMVSSVPKLMKGVPGTPTGTQ* 0

>NEUR3a_danRer Danio rerio (zebrafish) Deut.Acti.Otoc genomic full G?
0 MDRYTSKLSPAVDYSAGTFLLVI 1
2 AILSILGNAAVLLTAAWRHSVLKAPELLTVNLAVTDIGMALSMYPLSIASAFNHAWIGGDPSCLYYGLMGMIFSVASIMTLAVMGLVRYLVTGNPPK 1
2 SGSKFRRKTISILIGVIWMYSLLWAVFPILGWGGYGPEPFGLACSVDWMGYQHSLNRSSFIMALAILCTLMPCVVILFSYSGIAWKLHKAYQSIQSNDNLPNSGAVERKVTL 0
0 MGILISTGFIVSWAPYVFVSLWTMFRSEGEDSVVPIVSLLPCLFAKCSTVYNPLVYYVFRKSFRREIHQIRICCFQGCWDAVSKMTRGDGPEETSGTHETDNI* 0

>NEUR3b_danRer Danio rerio (zebrafish) Deut.Acti.Otoc genomic full G?
0 MDIYSSKLSSAVDYGIGAFLLLI 1
2 TILSILGNLMVLVMAYKRSNHMKPPELLSVNLAVTDLGAAVTMYPLAVASAWNHHWIGGDVSCVYYGLMGFLFGAASMMTLTIMAIVRFIVSLTLQSP 1
2 KEKISKRNAKILVATTWLYALLWAIFPLIGWGKYGPEPFGLSCTLDWRDMKEHSQSFVITIFLMNLILPAIIIVSCYCGIALRLYVTYKSMDDSNHVPNMIKMQRRLMV 0
0 IAVLISIGFVGCWAPYGIVSLWSIYRPGDSIPAEVSMLPCLFAKTSTVYNPFIYYIFSKTFKREVNQLSRFCGRSNICRPTDAKNRPENTIYLVCDVNKSKPGVEDLSLARSKENETQMLPNQDLHE* 0

>NEUR3a_tetNig Tetraodon nigroviridis (pufferfish) Deut.Acti.Perc genomic full G?
0 MDDKYMSKLSPPVDLWAGIYLVVI 1
2 ALLSVLGNASVLFSASRRLTPLKAPELLTVNLAVTDIGMALSMYPLSIASAFNHAWMGGDTACLYYGLMGMIFSITSIMTLAVMGMIRYLVTGSPPR 1
2 SGVQFQKKTICVVICAIWLYACLWAAFPLLGWGSYGPEPFGTACSIDWTGYGDSLNNATFIVAMSVLCTFLPCLVIFFTYFGIAWKLHKAYKSIKSSDFQYASVERRITL 0
0 IAVLISVGFLGSWAPYGLVSLWSILKDSSSIPPQVSLLPCLFAKSSTVYNPVIYYIFSQSFKLEVQQLFLCC* 0

>NEUR3_petMar Petromyzon marinus (lamprey) Deut.Agna.Hype genomic frag G? new exon
0 MAEQGEDDQFRSKLSPTADIAAGTFLLAV 1
2 AVLSLAGNGAVLGVAARRWAKLKAPELLSVNLALTDLGIAASIYPLAVASAWNHRWLGGQPVCTYYAFAGFFFGTASMGTLTAMAGVRYKGTSTQVH 1
2 VKQITKRAMLAVIVAVWAYALLWSCLPLLGWGR 2 1 YGVEPFGVSCTLAWAELQLTPGGVAFLYAMFVLCLLLPAIAIGLCYAGIVCKLRRAYREGRSKRRTPTARHVESRLTK 0

>NEUR4_ornAna Ornithorhynchus anatinus (platypus) Deut.Prot.Mono XM_001508128 full G?
0 MSLSHSLQVPWRNNLTFLNKEAQVSEQGETIIGIYLLAL 1
2 GWMSWFGNSMVIFILHRQRGILNPTDYLTFNLAVSDASVSVFGYSRGIIEIFNVFRDDGFLITSIWTCQ 0
0 VDGFLTLLFGLASINTLAMISVTRYIKGCHPHR 1
2 GHFINTANISVALILIWVSALFWSAGPVLGWGSYT 1
2 DRMYGTCEIDWAEANFSSICKSYIISIFFCCFFLPVSIMFFSYVSIIKMVKSSHTLAGADDPTDRQRRLDRDVTR 0
0 VSVVICTAFIVAWSPYAVISMWSAFGHSVPNLTSVLASLFAKSASFYNPIIYFGMNSKFRKDILVLLPCAKESKEPVKLKKFKNLRQKQGFTLQKPEKAHVLQVPDSGPMSLINTPPLGNRNSFDLACDNSDFECVRL* 0

>NEUR4_galGal Gallus gallus (chicken) Deut.Saur.Arch genomic full G? genome gappy
0 MSLQLSPQAPWRNNNISFLSREAAVTEQGETIIGFYLLAL 1
2 GWMSWFGNSVVIFVLYKQRHLLQPTDYLTFNLAVSDASISVFGYSRGIIEIFNVFRDDGFIITSIWTCQ 0
0 VDGFLTLLFGLASINTLTVISVTRYIKGCHPER 1
2 AHCISNSSMTVAMVLIWIAAFFWSAAPLLGWGSYT 1
2 DRMYGTCEIDWAKANFSTIYKSYIISIFICCFFLPVTVMVFSYVSIINTVKLSHALTGLSDPTERQRRMERDVTR 0
0 IVICTAFIIAWSPYAVLLLWSAYGHPVPNLPLYLSSLFAKSASFYNPIIYFGMSSKFRRDIFILFHCAKEVKDPVKLKRFKNLKQKQEPSQKEEKYAAEMHPAPSPDSGVGSPTNTPPPANREEYFGILDTPSNSPDIECDRL* 0

>NEUR4_taeGut Taeniopygia guttata (finch) Deut.Saur.Arch genomic full G?
0 MSVQFSAQAPWRNNNISFLTREAAVTEQGETIIGFYLLAL 1
2 GWLSWFGNSIVIFVLYKQRHVLQPTDYLTFNLAVSDASISVFGYSRGIIEIFNVFRDDGFIITSIWTCQ 0
0 VDGFLTLLFGLASINTLTVISVTRYIKGCHPER 1
2 GHCISNSSMSVALVLIWVAAFFWSAAPLLGWGSYT 1
2 DRMYGTCEIDWAKASFSTIYKSYIVSIFICCFFLPVTVMVFSYVSIINTVKLSHT LTGLGDPTDRQRRIERDVTR 0
0 VSLCTAFIIAWSPYAVISIWSAYGHPVPNLTSILASLFAKSASFYNPIIYFGMSSKFRRDIFIFHCAKELKDPVKLKRFKNLKPKQPQPSQKEEKYAPEMHPAPSPDSGVGSPTNSPPPANREVYFGILDTPSNNPNIECDRL* 0

>NEUR4_anocar Anolis carolinensis (lizard) Deut.Saur.Lepi genomic full G?
0 MSLQVSPQAPWRNNNVTFSNKEVPVSEQGETIIGFYLLAL 1
2 GWMSWFGNSIVIFVLYRQRAGLQPTDYLTFNLAVSDASVSVFGYSRGIIEIFNVFRDDGFLITSIWTCQ 0
0 VDGFLTLLFGLASINTLTVISVTRYIKGCHPDR 1
2 GKCISNSSISVALFLIWIAAFFWSVAPVLGWGSYr 1
2 DRMYGTCEIDWAKANFSTIYKSYIVSIFICCFFLPVSVMVFSYVSIINTVKSSHALSGVGDPTERQRRMERSVTR 0
0 VSLVVICTAFITAWSPYAVISMWSAYGYTVPNLTSILASLFAKSASFYNPIIYFGMSSKFRKDIFVLLHCAKEIKDPVKLKRFKNLKQKQEVSPSQREEKYAADVQPALSPDSGVGRSNTPPPVNREVYFGAFDTFSNNPDVECDRL* 0

>NEUR4_xenTro Xenopus tropicalis (frog) Deut.Amph.Anur genomic full G?
0 MSLQFPRPAPWRNNNLTLLQKENPLTEQGETIIGIYLLAL 1
2 GWLSWFGNSIVIFVLYKQRANLLPTDYLTFNLAVSDASTSVFGYSRGIIEIFNVFRDDGFLITSIWTCQ 0
0 VDGFLTLLFGLASINTLTLISVTRYIKGCHPQR 1
2 ANCISNGSITISLALIWIAALFWSVAPLLGWGSYR 1
2 DRMYGTCEIDWTKASFSTIYKSYIISIFICCFFLPVMVMVFCYVSIINTVKSSRALTSEGDLSERQRKMERDVTR 0
0 VSVVICTAFIVAWSPYAVISMWSACGYYVPSLTSILAALFAKSASFYNPLIYFGMSSKFRKDLCVVLPCAKAQKDPVKLKRYKDKKQGSAPRAREQTEIEQPVQLQPAPSQDSGVGSPSNTPPLRTKDVHIVDIDLVSDNPSYECDRL* 0

>NEUR4_danRer Danio rerio (zebrafish) Deut.Acti.Otoc genomic full G?
0 MSAQNPLQVVNIPWRNNNFSLMSRDPPLSDQGETIIGVYLLIL 1
2 GWLSWFGNSIVIFVLFRQRSTLQPTDYLTLNLAVSDASISVFGYSRGILEIFNIFKDSGYIISSVWTCQ 0
0 VDGFFTLVFGLSSINTLTVISITRFIKGCHPHK 1
2 AHCITNSTVAVCVVFIWIGAFFWSAAPVLGWGSYT 1
2 DRGYGTCEIDWVKANYSTIHKSYIISIFIFCFLVPVLLMLFCYISIINTVKRGNAMNADGDLSDRQRKIERDVTI 0
0 VSIVICTAFILAWSPYAVVSMWSAWGFHVPNLTSIFTRLFAKSASFYNPLIYFGLSSKFRKDVSVLLPCGREGRDPVRLKRFKRLRGRAEPPGAPAHTPHPQIALKNYNNHSKPHAGPAHCTGHAPSPDSGVGSHHETPPPQPRPQLFFIDVPEPEAESECVRL* 0

>NEUR4_tetNig Tetraodon nigroviridis (pufferfish) Deut.Acti.Perc genomic full G?
0 MEPSRPWRNSSVLGGGAEPPLSEQGETIIGVYLLLL 1
2 GWLSWFGNTVVLFVLVRQRSSLQPTDLLTFNLAVSDASISVFGYSRGIIQIFNVFQDSGFIISSIWTCE 0
0 VDGFLTLIFGLSSINTLTVISITRYIKGCQPSR 1
2 AALISRSSVSVCLLLIWTTAGFWSGAPLLGWGSYT 1
2 DRGYGTCEIDWSKAASSGVYRSYIISIFIFCFFIPVFIMLFCYISIINTVKRGNALAADGHLSHRQRTMERDVTV 0
0 ISVVICTAFIMAWSPYAVVSMWSAWGFHVPSTTSIVTRLFAKSASFYNPLIYFGMSSKFRKDVSLILPCAKERREVVLLQRFKNIKPKAAAAPPPPPLPVYRPKEKNEDEPKLSVHDNDSGVNSPPETPPSDAQEVFPVDPPSQIETSEYWSDRL* 0

>NEUR4_gasAcu Gasterosteus aculeatus (stickleback) Deut.Acti.Perc genomic frag G?
0 PVKVVNIPWRNNNLSNLNTDPPLSEQGETFIGVYLLVL 1
2 GWLSWFGNSLVMFVLYRQRASLQSTDFLTLNLAISDASISIFGYSRGILEIFNIFNDDGYLINWIWTCQ 0
0 VDGFFTLLFGLASINTLTVISVTRYIKGCHPNK 1
2 AYCISTNTIAVSLICIWTGAVFWSVAPLLGWGSFT 1
2 DRGYGTCEVDWSKANYSTIHKSYIISILIFCFFIPVMIMLFSYVSIINTVKSTNAMSADGFLSTRQRKVERDVTRV 0
0 ISIVICTAFITAWSPYAVVSMWSAWGFHVPSTTSIITRLFAKSASFYNPLIYFGMSSKFRKDVSVLVPCTRERREVVHLQHFKNIKPKAEAPPTPASLPVQKLGAKYAVPNPDADSGVNNPPQRPATDPQGDLNIDLPSHIETSEYWCDRL* 0

>NEUR4_calMil Callorhinchus milii (elephantfish) Deut.Chon.Holo genomic frag G?
0 MGCSLGWKVLLWFLHGILICPRPWRNHNSTFQPKEHPISEQGETIIGVYLLIL 1
2 GWLSWFGNSIVIFILYRQRLSLQPPDYLTLNLAVSDASISIFGYSRGIIEIFNVFRDDGFLITSIWTCQ 0
0 1
2 AVSISAGSIAASLVLIWIAAIFWSGAPLFNWGSYT 1
2 DRMYGTCEIDWSRASFSTIYKSYIISIFICCFFLPVFVMLFSYISIINTVKSSHAFAGNADLSDRQRRMEKDVTR 0
0 VSMVICTAFIIAWSPYAVISMWSASGYTVPQLTGIFASLFAKSASFYNPMIYFGLNSKFRKDIYILLPCVKEPKESVKLKRFKHLRHRPEQQQANKDRYAEELQQVASPDSGMGSPSKSPPLHNKDVFFVLWLRGLKK

>TMT_triCys Tripedalia cystophora (box_jelly) Cnid.Cubo.Cary EU310498 18577593 full G? c-opsin-like Schiff lysine mRNA with predicted introns
0 MADHGRNTTSNDTNPISKIPLDDFDPQRFYNFYTFMGSFIAGSACCSFLLNGLVIAVLIKYIRTITNTNIIVLSMSCANILIPLLGSPLSATSSLMRKWQFGNGGCTWYGFINTLS 1
2 GISGIYHLTFLSFERFITIVLPLKRDTILSTKNIYIGLGILWVAAIGVAGAPVFGWCEYIKE 1
2 GVRTSCSVAWSSKENMNVFSYNLFMIFTVFLLPMLVIIYCNYRFIKEVSIMSTRA 0
0 RGLQGGDSEMTASASKAEKQLTIMVITMIIAFNIAWLPYTVVSMVFLTGYGDVVGPMGASVPSVFAKTSVIYNPVIYCLLNRS 0
0 FRKMLCGNSVEPE* 0

>CUBOP_carRas Carybdea rastonii (sea_wasp) Cnid.Cubo.Cary AB435549 18832159 full G? cubop
MGANITEILSGFLACVVFLSISLNMIVLITFYRLRHKLAFKDALMASMAFSDVVQAIVGYPLEVFTVVDGKWTFGMELCQVAGFFITALGQVSIAHLTALAL
DRYFTVCRPFVATAIHGSMRNAGMVIFVCWFYASFWAVLPLVGWSNYDVEGDGMRCSINWADDSPKSYSYRVCLFVFIYLIPVLLMVATYVLVQGEMKNMRGRAAQLFGSESEAAL
KNIKAEKRHTRLVFVMILSFIVAWTPYTFVAMWVSFFTKQLGPIPLYVDTLAAMLAKSSAMFNPIIYCFLHKQFRRAVLRGVCGRIVGGNAIAPSSTAVEPGQTLASGTAES*

>ENCa_nemVec Nematostella vectensis (anemone) Cnid.Anth.Hexa genomic full G? Schiff lysine no cdna complete 1 exon
0 MIDNALGRHEANIVLGYYIAIFVIGFVTNTIVVIIFISSQRLHTTPNLILFSMSVCDWLMATMAKSVGIYGNARYWPTVGKVTCDYYAFATSAIGYASILHLAALAVEKRMAVVSPMTNSFNGRRMLVIIATLWGFAILW
AVFPLIGWSSYGPEPGYVSCSITWYTTDHNNVSYIICVSVLFFLIPIVTMTFCFASIYHTIRNLSHEATARWGSDARATQETIRAKAKTAKMAFLMVMCFLFAWTPYAVVSLWTTFGDTHRIPALLGVLPSLFAKLSSCY
NPIIYFFMYTKFRCAGKALLYQEHH* 0

>ENCb_nemVec Nematostella vectensis (anemone) Cnid.Anth.Hexa genomic full G? Schiff lysine NC-extended 1 exon
0 MSNEALRRHEANIVLGYYIAIFVIGFVTNTIVVITFIFSKRLHTTPNLILFSMSVCDWLMAAMAKSVGIYGNARYWPTVGKVTCDYYAFATSAIGYASILHLAALAVEKRMAVASP
MTNSLNERRMLVIIATLWGFAILWAVFPLIGWSSYGPEPGYVSCSITWYTTDHNNVSYIICISVLFFFVPIVTMTFSFASIYKAIRNISHEAIARWGSHARATQETIKAKAKTAKMAF
LMVMCFLFAWTPYAVVSLWTTFGGTHRNPALLGVLPSLFAKLSSCYNPIIYFFMYTKFRRAAKLLFIKKVIRPTEAERSRVLSGIRTRAASTFAVKLTVHAEKGQQIAPNITPQGAVKGPVESIEDNLQKIETITPCTSV* 0

>ENCc_nemVec Nematostella vectensis (anemone) Cnid.Anth.Hexa genomic full G? Schiff lysine C-extended 1 exo
0 MELFTSYHAITVMYSLLAAGAFVLNGIVLIIFLATRSLRTIPNMILLSMAWADWLMACLADAVGAYANANNWPSMVGGLCVYYGFITTALGLTSMIHLTALSVERFVTVTIPMTRPITETQMLLVVTFLWAFSFLWAIFP
LVGWSSYGPEPGYAACSIAWYRQDLNNMSYILCLFMFFFFLPIVIMIACFSSIYFTVRKLTRDSMRRWGASSDSTQQTLAAERKTAWMSFIMVLAFLFAWVPYAVVSLYASFGGVTTIPKLMSTLPAMLAKTSACYNPII
YFFMYSKFRKAFQRFFFKNVITPSQTGGSSTINSASVIPTSFPRASYAVRSSSVLPSSTASHSFRSRE* 0

>ENC_aneVir Anemonia viridis (anemone) Cnid.Anth.Hexa FK729339 19627569 frag G? symbiotic
KDAVARWGNKSPPTQQTMQAQKKTIRMSLVMVFAYLLAWTPYALTSLYSSFIASDITPLLSVMPALFAKLSSCYNPIIYFFMYSKFR
KAAKKMIRRNLVGHDSNSGQGVSNTFATSFPRPISFLRYKRSAVAPLSDIPQVSSVDLPQVGRENDVTVQQDKASEINT* 0

>MEL1_acrDig Acropora digitifera (stony_coral) BACK01045931 
METASGVPIVIEASVHHTISFLYFLLALFSFSLNSVVILTFLLDRSLLFPANLIILSIAISDWLMSVVPNIMGGVANASNDLPFTDWSCTVFAFVATLLG
LSNMLHHAAFALDRYMVITRPMRANHSMKRILAVIAFLWCFALTWSLFPLVGWSAYVREAGDIACSVNWQSDNPSDTSYMVCLFFFFYFVPLAVIVYCYA
FMIKSVRFMTKNAQKIWGVRSAAALETVQATWKMAKIGLIMVVGFFVAWTPYAVVSFIIAFDLVKDIPTVAEIVPSMFAKTASVYNPIIYFFSFAYCKNQ
SVNKCINQSTVQSKNFKLS*

>MEL2_acrDig Acropora digitifera (stony_coral) BACK01017283
MPGFQNKSEEPQPTEGISSQDRFIVASFYALLAVTALGLNTPVLITFMKDRKLRVLSNRIILSITIGDWLHAFLAYPVAVFANASHDSQGLTGVVCSWYG
FITVFLSFGIMLHHATFAVERAIVIQFATTSLTNAKTINFMVASLWVFALLWSSFPLFGWSAYVPHVVLCSLDWQSRDLRDVVFVYCIFFVFFLVPIVVM
VTSYYKIFQTVKKMTQNARDLWGEKAAPTREAFESQKKTARMACVMSFCFLFAWTPYAAVSLYVFLWKPQSMAPSISIVPALFAKTSACFNPVIYFLLFR
KFRESLKQTMCGFFMDPKTGTNETNKNKRHVLKNTESKCACVKINNLSPRDPCNLHQRSDCRSVGNSKSHITVD*

>ENC1_acrDig Acropora digitifera (stony_coral) BACK01046894 
MLTFACGSTHIYNMSAVFYGFLAAGTVFLNVIVILTFFKVRALLIPASFPILSLAMADVFLASAVMPLGIASCASGHWIFGAVGCNWYAFMHTTVGLSSI
LHHAILALERCLTIFEPMKKHFDRHTMTRTLAFLWTLVSLWSLCPILGWSAYVPEGTGTICSIEWHSKNSLDVIFVVSTFVFFCFVPFVFIAVCYTAIAF
HLRKVSKTAKRTWGKNSQITKDGVIVKRKAVTHGAIMVTTVMITWLPYSMVAFYTLLGFEKVKLSALAYAITAMFAKTSTLVNPIICFFWYRRFREGTKK
LCNRIMDFILRKHRRASNTSHSSKTVWYDGKTIVFRRSVVDSCSTRTQNDRGRSS*

>ENC2_acrDig Acropora digitifera (stony_coral) BACK01016849 11738 bp INV 28-JUL-2011 DOI:10.1038/nature10249
MTALIYSVFAIIAAVICVLGVPLNGLVCWVFYNNRELLNAPNIFIASVAFSDFLYCISCLPLLVISNAYGKWIYGPIGCKATAFIATWSGLTSLMNLSVA
SYERYSTLAFLCTKNRTFAKRTATCYSAAMWLYALFWSLMPLCGWSGFELEGIGTSCSVRWKSKNMLDMSYNLCLIIACYVLPVSVLVTSYYKCYREIAK
STWRAKSTWGRQSPFTKRTFVMERKMMALFGVMTVAFLVAWTPYAVVSLISMIGGPDVISDVTASIPAYFAKSSSCYNPVIYVFLYKRLRRQMRFAVRRD
NCSSSRKGTSSDSTMAHHSETKRLRSTIELTDNYSTRNRPENI*
                   
>ENC3_acrDig Acropora digitifera (stony_coral) BACK01015014 possibly N-incomplete
MVAPHFAGFAIAASLFGSCGIVLNFTVCLTYILNRRLLDASNIFILNISAGDFLYSITALPMLVTSNALGKWSFGEGGCVAYGFLTTFFALGAMMNLAGA
AYERYVTMCKLYESGECQFSRRKAAFLCSVLWTYALIWSIAPIFGWSSYKQEGIGTSCSTDWKSRDVKSLSYGVVLIITCFVVPVAVILYCHIEAYKVTR
KLGKQAQQNWGSHTRATRETLKAQKKMGEIAVVITVGFVVAWTPYTVASVIGMYDPNLVSDVGASIPAYFAKSSSCYNPFIYLFMYKKLRIGMVRLLCCM
KKQVYPSSSGLTRDPTCQEIPMVVPVNNPS*

>ENC4_acrDig Acropora digitifera (stony_coral) BACK01020962 possibly N-incomplete
MTKTAAWSTVFLIIEFVVCLLGIFFNCLVISIIFKNANRLAAPGFLVLSMALSDVLSCSVAVPFSIVAHFQKKWPFGMAGCEAHAFMVFLFALVSITHLA
AISAGKYLTISRSLTRESYFDRRQVLLVVIACWLYSLAFSVAPLVGWSRYGLEGTNATCSIKWDSSEPSDKAYFGVVFIACFFLPMGVITLCYYKIHKVS
KRIVENIQGQSIATSAMSRTHALVKKHRRSAMYFLAIVAAFMLAWSPYAIVSLIVVLSGTMDPIATSACSVFAKTSFLVNPFLYAIFSRSFRRRLALVFP
MPRQNRQEGRQERNCNALPPSQSQPFVL*

>ENC5_acrDig Acropora digitifera (stony_coral) BACK01011015
MDQIKIWKMLFVVIKFIVSIFGGFFNGLVVLTIRKNLRRLPSSSYLILSIAFSDFIASVVAIPFSIVIHFVGSWPLRLCRAHAFMVFFLGIVTITHLTCF
AVEKYLTITRSLSKLSFFSKKQTLVVVMACWFYSLCFSLAPLLGWASYGLEGSNDTCSIKWDSSLAKDHIYFILVFLACYLLPIVLITSSYFKILRISKR
ILKATPRVGGIGETMAQALMRKHRRGALYFLSVIAVFLMSWTPYAIISVLVIFKGVNLFPLALSACGVFAKMSFMLNPIMYFAFSHNFRLLVKRTFCICD
RLDSNSEGKKR*

>CNOP1_acrDig Acropora digitifera (stony_coral) BACK01019215 tandem fragment last exon at beginning of contig
1 LLRRDVVTEDSRIKLRRRHWQMKLLRLTAVAITAFMLSWSPYSLVSLTSIFRGNSVLSTGEAEVPALMAKASVIYNPIVYTVMNRRFRRTLRHIVSCMTCRLLSFVWPTMHGEKQETKKRVTSTMTVTSSTPAPEGNFPEILVSLHQVPF*

>CNOP2_acrDig Acropora digitifera (stony_coral) BACK01019215 MEL
0 MQFSREEDPPSGFNWNNAWFIAYGVVMIAVLSIGFLGNTMTVLILRKHEHASKSLTPLMINLAIASLIIIVLGYPLVISLVVRGSHVTKEDPTCRWSAFINGTV 1
2 GISSIATLTEMSLVINYSLHRMNPNVRLTKRNMALLIAGAWLYGLVSMFPPLVGWNRFVPGAVRISCGPDWTDKSASGVSYNLVLVVLGFFLPLCVMIKAYYEIYRS 2
1 LLRSREMLISANGSFQLRQKLYIKKLVRMTVLAIAAFMLSWAPYCFVSIVAIFKGSHIITSGEAEIPELMAKASVIYNPVVYLITNSSYRASFWKVISCQKQTMIVHVRENLMPNGPSRRTLRSRRMAVLLKPLNEVSVYNGGYVVAMGFASVRDL* 0

>CNOP3_acrDig Acropora digitifera (stony_coral) BACK01018578 TMT
0 MLESSNQSAEETILISKASYYAYGVVMFFILTVGFLGNVMTLLVLFQHEHRKKAMTPYMVNIALADIFIILFGYPVAMRANLRGKILESSHCSWGGFVNGAV
GISSIFTLTEMSFVSYHGLRQVNRSSRFSPFQVVCSVAVAWLYGVLCMLPPFLGWNRFVVSASRISCCPDWSGKSISDAAYNLLLVFFGFVAPLTAMTVCYYKIYR 2
1 SLVHHAVVPGNLPQIQLRRRQSELKVAKVTAMNVIAFLLSWAPYCCVSLAAVFTKQFVLVDWEAEIPELLAKASVIYGPIIYSTMHSRFQATLFRILHCRRRVILAPQFITDATRNNCSARMATDRTQGTSHIDQRFLQLPLQAMKRRVAVSYGGTAICKRESSAFVSG* 0

>CNOP4_acrDig Acropora digitifera (stony_coral) BACK01002540 TMT
0 MTTRSDDNPNSARRPQQIAFIVYVVIMTVILIVGFLGNLFTIIVLRCPEHKKKIITPLMMNLAFADIIIIVFGYPVVMASNFTEHNVLTNPMLCVWSGFINGSV
GIASIANLTMMSLVMFKSLNKVGTVKKIPWKKMLAMILFTWVYGVLSMFPPLVGWNKFVPGASGISCCPDWSPDTKAAVGYNILLVFVGFVLPLTIIIFCYYRMYR 2
1 FIHTQQPVTGNASIQASRRRSEIKIVRMIALAIAAFVLSWSPYCFVSIAGTIRGSSLLTAGEAEVPDLLAKASVIYNPIVYTVMNDRFRGTLLRVIPCRRRWFNGDINPTVSVSAPNSQDGNSHNFRERPQSVKGNSTV* 0

>CNOP5_acrDig Acropora digitifera (stony_coral) BACK01002513 and near identical BACK01007224
0 MTTSFRSNMTDEWGTHKYFSAGYIAYGVVMFCILSLGFVGNTLTVLVLTKREHRWRGVTPLMINLAVADLLIIIFGYPTQVHANFTGDGVPNDSHCNYRGFIN
GIVGITCIFTLTEMGVVSYSGLRRVSGNVRLSSYQVACLIGAAWCYGALCMLPPLLGWSKFVISASKLSCSPNWSGQSTADKAYTLLLVTFGFFAPLTVMIISYYKTFW 2
1 VVRRHFVPGNTAVQLRQRKSMLRIVHVTLMSVISMMLSWAPYCFISLASVVRGKPVIENWEAEIPELLAKASVVYNPLIYTFMNKSFRMTLFRIVGLHRCFGAGHEVAPTAAIQKRPNVLQIQFHRHSSEVEVRTPRVPPIE* 0

>CTENOP1_plePil Pleurobrachia pileus (sea_gooseberry) Cten.Typh.Pleu FP995093 CU419614 full G? ctenop EQY 
0 MELRVSLSLIMACVCTGSVF 1
2 GNMLVFISLVKERPLPNPAVEMIFRHLSLANLVLAGIGEPLVVVSLAA 1
2 GKWVWGESMRYFEAFWVTTFGLFSMMILGLISFEQYSRFVRQKQLKTHQ 0
0 VAVLLSGIYFLAFFFGIAPLVGWCEYGPE 1
2 GYGVSNSLMWNNLNDNNASYIICAMIIGYFFPLIIIMFCYRAIYRLVQ 0
0 AQLNTSVVKMTVSANVTSLSTNRNHIML 0
0 VQERQLASTITFVILSFFFAWTPYVFVNIINMFSTLILKYRILAT 0
0 IPALFAKSSTLWWIIVYCLMDVRIKKACRKTCLRFKRSFRVWYFS* 0

>CTENOP1_mneLei Mnemiopsis leidyi AGCP01013851 AGCP01013853 77% identical CTENOP1_plePil
0 MGLRISLSIAMGCVCVGSVF 1
2 GNLLVLISLVRERPLPNPAVQLIFRHLSLANFLLACIGEPLVVISLAS 1
2 GKWVWGESMRLFEAFWVTTFGLLSMMILALISLEQYSRFVRQKQLRTVQ 0
0 VAVLLSGIYFLAFFFGIAPLVGWCEYGPE 1
2 GYGVSNSLLWNELTDNSASYIVTVMIVGYFFPLVIITYCYRSIYQLVQ 0
0 AQSNVAIVRTMVSVNVTSLAVNRNHSLI 0
0 VQERKLATTITFVILSFFFAWTPYVLINLLNMFTTWVVKYKILAT 0
0 IPALFAKSSTLWWIIIYSMMDKRIKKACRKTCEHFQRALRIWYFSS* 0

>CTENOP2_plePil Pleurobrachia pileus (sea_gooseberry) Cten.Typh.Pleu FQ011385 ERY 33-203 range in bosTau rhodopsin
0 MTTAVDDEMMGDEEPKVVYTLASLLAVNALCSIA 1
2 GNALVIYTFLKEKPLGAPLRVILTHLAVTNLIIASIGEPMVVISGYS 1
2 MRWVFGEMGRGFEAFIVTSCGLMAMSLLALVSIERYLR 2
1 VTPRQRFPFTEPTAVKCCSFLWVFNVIYASLPFYGIAAWEGE 1
2 GIGISNSITWTTEHTQDFVYIICMMSTGYFIPLFIIAFCY  2

>CTENOP2_mneLei Mnemiopsis leidyi AGCP01013109 AGCP01013108 AGCP01013106
0 MSSPNDEPTVDSDPKAVYILTSLLCMNCIFSLV 1
2 GNMLVIYTFLRERPLGAPLRTILCHLAITNLMIAGIGEPMVVISGFN 1
2 VRWVFGEMGRKIEAYTVTASGLMAMSLLAFVSIERYLR 2
1 VTPGQKFLIRQTTSVRVCTLMWIYNVIYASLPFYGIAAWRGE 1
2 GIGISNSLSWDTNNKIDVAYVMVMMATGYFIPLAVITFCYNRYVEIQQRLSTFL 2
  SKLKMTMETNITSAANSQN
0 AAEKKISNVVAIIIVSFFISWTPYTIVNLLVTFDKAGR 2
1 GINATIPAFLAKTSTVWSPIIYCFMNGEVSIFVLEGGHVMKYLYL* 0

GPCR outgroup sequences

OpsinOrigins.jpg

It is sometimes convenient to have a close-in outgroup to opsins selected from the roughly 100,000 GPCR receptors available at GenBank. The set below of 29 non-opsin GPCRs serves satisfactorily as proxy for an exhaustive GPCR compilation. It was constructed by taking best-blast in turn of each human opsin against all other human GPCR then collating the lists, winnowing out repeated entries and too-recent gene family expansions. TACR2 (tachykinin receptor) and SSTR1 (somatostatin receptor) are the best single representatives.

These are usefully supplemented with non-opsin GPCR having determined 3D structures, some nearest neighbors in recent GRAFS classification trees, and two astonishingly close pre-opsins (called UROPS1 and UROPS2 here) from Trichoplax, an early diverging eukaryote lacking opsins. Note TSHR binding of heterotrimeric G protein has recently been modeled in great detail.

The aligned sequences below have been trimmed from full length at both ends to the earliest indications of conservation. This alignable region begins at the GN region of TM1 and extends to the FR motif just beyond TM7. Highly conserved residues are shown in red and less conserved residues in blue. The Schiff base lysine (position -16 relative to the FR end of TM7) does not occur outside of opsins. Note many conserved patches in these GPCR are very similar to those of opsins, implying those residues have no utility in distinguishing opsins from non-opsins.

Conserved outgroup residues shared with opsins evidently describe commonalities needed for generic GPCR structure and signaling but not specifically for photobiology. Departures from the norm in certain opsin classes might indicate they are no longer signaling or are signaling constituitively. Opsins also have conserved diagnostic residues and even regions not found in any GPCR.

These close-in outgroup sequences illuminate, as discussed elsewhere, the origin of opsins.

OpsinOutgroup.jpg

Exon count refers to trimmed alignable sequences. Some idiosyncratic loops have been deleted. Intron positions and phases are indicated relative to bovine
rhodopsin numbering (sometimes uncertain due to gapping issues). These GPCR do not significantly conserve major opsin introns, so parental relations remain obscure.

>GPR21_homSap Homo sapiens (human) orphan receptor good match mollusk opsin 1 exon 
IVFLTVLIISGNIIVIFVFHCAPLLNHHTTSYFIQTMAYADLFVGVSCVVPSLSLLHHPLPVEESLTCQIFGFVVSVLKSVSMASLACISIDRYIAITKPLTYNTLVTPWRLRLCIFLIWLYSTLVFLPSFFHWGKPGYH
GDVFQWCAESWHTDSYFTLFIVMMLYAPAALIVCFTYFNIFRICQQHTKDISERQARFSSQSGETGEVQACPDKRYAMVLFRITSVFYILWLPYIIYFLLESSTGHSNRFASFLTTWLAISNSFCNCVIYSLSNSVFQR

>GPR52_homSap Homo sapiens (human) orphan receptor immediate outgroup to opsins 1 exon
IVLLTFLIIAGNLTVIFVFHCAPLLHHYTTSYFIQTMAYADLFVGVSCLVPTLSLLHYSTGVHESLTCQVFGYIISVLKSVSMACLACISVDRYLAITKPLSYNQLVTPCRLRICIILIWIYSCLIFLPSFFGWGKPGYH
GDIFEWCATSWLTSAYFTGFIVCLLYAPAAFVVCFTYFHIFKICRQHTKEINDRRARFPSHEVDSSRETGHSPDRRYAMVLFRITSVFYMLWLPYIIYFLLESSRVLDNPTLSFLTTWLAISNSFCNCVIYSLSNSVFRL

>MTNR1A_homSap Homo sapiens (human) melatonin receptor circadian rhythm 2 exons 71-12
  LIFTIVVDILGNLLVILSVYRNKKLRNA 1
2 GNIFVVSLAVADLVVAIYPYPLVLMSIFNNGWNLGYLHCQVSGFLMGLSVIGSIFNITGIAINRYCYICHSLKYDKLYSSKNSLCYVLLIWLLTLAAVLPNLRAGTLQYDPRIYSCTFAQ
SVSSAYTIAVVVFHFLVPMIIVIFCYLRIWILVLQVRQRVKPDRKPKLKPQDFRNFVTMFVVFVLFAICWAPLNFIGLAVASDPASMVPRIPEWLFVASYYMAYFNSCLNAIIYGLLNQNFRK

>HRH2_homSap Homo sapiens (human)  histamine receptor 1 exon
LAVLILITVAGNVVVCLAVGLNRRLRNLTNCFIVSLAITDLLLGLLVLPFSAIYQLSCKWSFGKVFCNIYTSLDVMLCTASILNLFMISLDRYCAVMDPLRYPVLVTPVRVAISLVLIWVISITLSFLSIHLGWNS
RNETSKGNHTTSKCKVQVNEVYGLVDGLVTFYLPLLIMCITYYRIFKVARDQAKRINHISSWKAATIREHKATVTLAAVMGAFIICWFPYFTAFVYRGLRGDDAINEVLEAIVLWLGYANSALNPILYAALNRDFRT

>SSTR1_homSap Homo sapiens (human) somatostatin receptor SOG Rgamma class 1 exon
YSVVCLVGLCGNSMVIYVILRYAKMKTATNIYILNLAIADELLMLSVPFLVTSTLLRHWPFGALLCRLVLSVDAVNMFTSIYCLTVLSVDRYVAVVHPIKAARYRRPTVAKVVNLGVWVLSLLVILPIVVFSRT
AANSDGTVACNMLMPEPAQRWLVGFVLYTFLMGFLLPVGAICLCYVLIIAKMRMVALKAGWQQRKRSERKITLMVMMVVMVFVICWMPFYVVQLVNVFAEQDDATVSQLSVILGYANSCANPILYGFLSDNFKR

>OPRM1_homSap Homo sapiens (human) opioid receptor mu 3 exons 64-21 182-12 ?
  YSIVCVVGLFGNFLVMYVIVR 2
1 YTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGTWPFGTILCKIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVMFMATTKYRQ 1
2 GSIDCTLTFSHPTWYWENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALVTIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKR

>GALR1_homSap Homo sapiens (human) galanin receptor SOG Rgamma 3 exons 225-00 251-00 ?
  FGLIFALGVLGNSLVITVLARSKPGKPRSTTNLFILNLSIADLAYLLFCIPFQATVYALPTWVLGAFICKFIHYFFTVSMLVSIFTLAAMSVDRY
VAIVHSRRSSSLRVSRNALLGVGCIWALSIAMASPVAYHQGLFHPRASNQTFCWEQWPDPRHKKAYVVCTFVFGYLLPLLLICFCYAK 0
0 VLNHLHKKLKNMSKKSEASKKK 0
0 TAQTVLVVVVVFGISWLPHHIIHLWAEFGVFPLTPASFLFRITAHCLAYSNSSVNPIIYAFLSENFRK

>CCR4_homSap Homo sapiens (human) chemokine (C-C motif) receptor 1 exon
YSLVFVFGLLGNSVVVLVLFKYKRLRSMTDVYLLNLAISDLLFVFSLPFWGYYAADQWVFGLGLCKMISWMYLVGFYSGIFFVMLMSIDRYLAIVHAVFSLRARTLTYGVITSLATWSVAVFASLPGFLFSTCY
TERNHTYCKTKYSLNSTTWKVLSSLEINILGLVIPLGIMLFCYSMIIRTLQHCKNEKKNKAVKMIFAVVVLFLGFWTPYNIVLFLETLVELEVLQDCTFERYLDYAIQATETLAFVHCCLNPIIYFFLGEKFRK

>BDKRB2_homSap Homo sapiens (human) bradykinin receptor 1 exon
LWVLFVLATLENIFVLSVFCLHKSSCTVAEIYLGNLAAADLILACGLPFWAITISNNFDWLFGETLCRVVNAIISMNLYSSICFLMLVSIDRYLALVKTMSMGRMRGVRWAKLYSLVIWGCTLLLSSPMLVFRTMKEYS
DEGHNVTACVISYPSLIWEVFTNMLLNVVGFLLPLSVITFCTMQIMQVLRNNEMQKFKEIQTERRATVLVLVVLLLFIICWLPFQISTFLDTLHRLGILSSCQDERIIDVITQIASFMAYSNSCLNPLVYVIVGKRFRK

>GPR17_homSap Homo sapiens (human) uracil/cys-leukotriene dual receptor 1 exon
YLLDFILALVGNTLALWLFIRDHKSGTPANVFLMHLAVADLSCVLVLPTRLVYHFSGNHWPFGEIACRLTGFLFYLNMYASIYFLTCISADRFLAIVHPVKSLKLRRPLYAHLACAFLWVVVAVAMAPLLVSPQT
VQTNHTVVCLQLYREKASHHALVSLAVAFTFPFITTVTCYLLIIRSLRQGLRVEKRLKTKAVRMIAIVLAIFLVCFVPYHVNRSVYVLHYRSHGASCATQRILALANRITSCLTSLNGALDPIMYFFVAEKFRH

>CYSLTR1_homSap Homo sapiens (human) cys-leukotriene receptor 1 exon
YSMISVVGFFGNGFVLYVLIKTYHKKSAFQVYMINLAVADLLCVCTLPLRVVYYVHKGIWLFGDFLCRLSTYALYVNLYCSIFFMTAMSFFRCIAIVFPVQNINLVTQKKARFVCVGIWIFVILTSSPFLMAKPQKDE
KNNTKCFEPPQDNQTKNHVLVLHYVSLFVGFIIPFVIIIVCYTMIILTLLKKSMKKNLSSHKKAIGMIMVVTAAFLVSFMPYHIQRTIHLHFLHNETKPCDSVLRMQKSVVITLSLAASNCCFDPLLYFFSGGNFRK

>P2RY8_homSap Homo sapiens (human) purinergic receptor AMIN Ralpha class 1 exon
YSLVAAVSIPGNLFSLWVLCRRMGPRSPSVIFMINLSVTDLMLASVLPFQIYYHCNRHHWVFGVLLCNVVTVAFYANMYSSILTMTCISVERFLGVLYPLSSKRWRRRRYAVAACAGTWLLLLTALSPLARTDLTY
PVHALGIITCFDVLKWTMLPSVAMWAVFLFTIFILLFLIPFVITVACYTATILKLLRTEEAHGREQRRRAVGLAAVVLLAFVTCFAPNNFVLLAHIVSRLFYGKSYYHVYKLTLCLSCLNNCLDPFVYYFASREFQL

>HCRTR1_homSap Homo sapiens (human) orexin receptor Rbeta class 7 exons 57-12 117-00 187-12 226-00 276-21 310-12
  YVAVFVVALVGNTL 1
2 VCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQ 0
0 AVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWA 1
2 DDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQ 0
0 IPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRGRAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKR 2
1 VFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLS 1
2 GKFRE

>TACR2_homSap Homo sapiens (human) tachykinin receptor Gq-coupled SOG Rgamma class first gc-ag 5 exons 135-21 202-21 250-00 ? 312-21
  YLALVLVAVTGNAIVIWIILAHRRMRTVTNYFIVNLALADLCMAAFNAAFNFVYASHNIWYFGRAFCYFQNLFPITAMFVSIYSMTAIAADR 2
1 YMAIVHPFQPRLSAPSTKAVIAGIWLVALALASPQCFYSTVTMDQGATKCVVAWPEDSGGKTLLL 2
1 YHLVVIALIYFLPLAVMFVAYSVIGLTLWRRAVPGHQAHGANLRHLQAMKK 0
0 FVKTMVLVVLTFAICWLPYHLYFILGSFQEDIYCHKFIQQVYLALFWLAMSSTMYNPIIYCCLNHR 2
1 FRS

>NMUR2_homSap Homo sapiens (human) neuromedin U receptor 4 exons 229-00 ? 256-12 291-12
  YVPIFVVGVIGNVLVCLVILQHQAMKTPTNYYLFSLAVSDLLVLLLGMPLEVYEMWRNYPFLFGPVGCYFKTALFETVCFASILSITTVSVERYVA
ILHPFRAKLQSTRRRALRILGIVWGFSVLFSLPNTSIHGIKFHYFPNGSLVPGSATCTVIKPMWIYNFIIQVTSFLFYLLPMTVISVLYYLMALR 0
0 LKKDKSLEADEGNANIQRPCRKSVNKML 1
2 FVLVLVFAICWAPFHIDRLFFSFVEEWSESLAAVFNLVHVVS 1
2 GVFFYLSSAVNPIIYNLLSRRFQA

>QRFPR_homSap Homo sapiens (human) pyroglutamylated RFamide peptide receptor MEC Ralpha class 6 exons 105-12 157-12 180-00 247-21 277-12
  GVLIFALALFGNALVFYVVTRSKAMRTVTNIFICSLALSDLLITFFCIPVTMLQNISDNWLG 1
2 GAFICKMVPFVQSTAVVTEILTMTCIAVERHQGLVHPFKMKWQYTNRRAFTML 1
2 GVVWLVAVIVGSPMWHVQQLE 0
0 IKYDFLYEKEHICCLEEWTSPVHQKIYTTFILVILFLLPLMVMLILYSKIGYELWIKKRVGDGSVLRTIHGKEMSKIAR 2
1 KKKRAVIMMVTVVALFAVCWAPFHVVHMMIEY 1
2 SNFEKEYDDVTIKMIFAIVQIIGFSNSICNPIVYAFMNENFKK

>GPR19_homSap Homo sapiens (human) orphan receptor 19 1 exon
FGILWLFSIFGNSLVCLVIHRSRRTQSTTNYFVVSMACADLLISVASTPFVLLQFTTGRWTLGSATCKVVRYFQYLTPGVQIYVLLSICIDRFYTIVYPLSFKVSREKAKKMIAASWIFDAGFVTPVLFFYGS
NWDSHCNYFLPSSWEGTAYTVIHFLVGFVIPSVLIILFYQKVIKYIWRIGTDGRTVRRTMNIVPRTKVKTIKMFLILNLLFLLSWLPFHVAQLWHPHEQDYKKSSLVFTAITWISFSSSASKPTLYSIYNANFRR

>PPYR1_homSap Homo sapiens (human) pancreatic polypeptide receptor MEC Ralpha class 1 exon
YSIETVVGVLGNLCLMCVTVRQKEKANVTNLLIANLAFSDFLMCLLCQPLTAVYTIMDYWIFGETLCKMSAFIQCMSVTVSILSLVLVALERHQLIINPTGWKPSISQAYLGIVLIWVIACVLSLPFLANSILENVFHKNHS
KALEFLADKVVCTESWPLAHHRTIYTTFLLLFQYCLPLGFILVCYARIYRRLQRQGRVFHKGTYSLRAGHMKQVNVVLVVMVVAFAVLWLPLHVFNSLEDWHHEAIPICHGNLIFLVCHLLAMASTCVNPFIYGFLNTNFKK

>NPY1R_homSap Homo sapiens (human) neuropeptide Y receptor Rbeta class 2 exons 225-00
  YGAVIILGVSGNLALIIIILKQKEMRNVTNILIVNLSFSDLLVAIMCLPFTFVYTLMDHWVFGEAMCKLNPFVQCVSITVSIFSLVLIAVERHQ
LIINPRGWRPNNRHAYVGIAVIWVLAVASSLPFLIYQVMTDEPFQNVTLDAYKDKYVCFDQFPSDSHRLSYTTLLLVLQYFGPLCFIFICYFK 0
0 IYIRLKRRNNMMDKMRDNKYRSSETKRINIMLLSIVVAFAVCWLPLTIFNTVFDWNHQIIATCNHNLLFLLCHLTAMISTCVNPIFYGFLNKNFQR

>PRLHR_homSap Homo sapiens (human) prolactin releasing hormone receptor 1 exon
YSVVVVVGLVGNCLLVLVIARVRRLHNVTNFLIGNLALSDVLMCTACVPLTLAYAFEPRGWVFGGGLCHLVFFLQPVTVYVSVFTLTTIAVDRYVVLVHPLRRRISLRLSAYAVLAIWALSAVLALPAAVHTYHVELKP
HDVRLCEEFWGSQERQRQLYAWGLLLVTYLLPLLVILLSYVRVSVKLRNRVVPGCVTQSQADWDRARRRRTFCLLVVVVVVFAVCWLPLHVFNLLRDLDPHAIDPYAFGLVQLLCHWLAMSSACYNPFIYAWLHDSFRE

>GPR161_homSap Homo sapiens (human) orphan receptor 161 2 exons 135-21
  IIVITIFVCLGNLVIVVTLYKKSYLLTLSNKFVFSLTLSNFLLSVLVLPFVVTSSIRREWIFGVVWCNFSALLYLLISSASMLTLGVIAIDR 2
1 YYAVLYPMVYPMKITGNRAVMALVYIWLHSLIGCLPPLFGWSSVEFDEFKWMCVAAWHREPGYTAFWQIWCALFPFLVMLVCYGFIFRVARVKARKVHCGTVV
IVEEDAQRTGRKNSSTSTSSSGSRRNAFQGVVYSANQCKALITILVVLGAFMVTWGPYMVVIASEALWGKSSVSPSLETWATWLSFASAVCHPLIYGLWNKTVRK

>ADRA1D_homSap Homo sapiens (human) alpha-1D-adrenergic receptor PUR Ralpha class 2 exons 274-12
  LAAFILMAVAGNLLVILSVACNRHLQTVTNYFIVNLAVADLLLSATVLPFSATMEVLGFWAFGRAFCDVWAAVDVLCCTASILSLCTISVDRYVGVRHSLKYPAIMTERKAAAILALLWVVALVVSVGPLLGWKEPV
PPDERFCGITEEAGYAVFSSVCSFYLPMAVIVVMYCRVYVVARSTTRSLEAG VKRERGKASE VVLRIHCRGAATGADGAHGMRSAKGHTFRSSLSVRLLKFSREKKAAKTLAIVVGVFVLCWFPFFFVLPL 1
2 GSLFPQLKPSEGVFKVIFWLGYFNSCVNPLIYPCSSREFKR

>TRHR_homSap Homo sapiens (human) thyrotropin-releasing hormone receptor 2 exons 251-00
  VLIICGLGIVGNIMVVLVVMRTKHMRTPTNCYLVSLAVADLMVLVAAGLPNITDSIYGSWVYGYVGCLCITYLQYLGINASSCSITAFTIERYIAICHPIKAQFLCTFSRAKKIII
FVWAFTSLYCMLWFFLLDLNISTYKDAIVISCGYKISRNYYSPIYLMDFGVFYVVPMILATVLYGFIARILFLNPIPSDPKENSKTWKNDSTHQNTNLNVNTSNRCFNSTVSSRKQ 0
0 VTKMLAVVVILFALLWMPYRTLVVVNSFLSSPFQENWFLLFCRICIYLNSAINPVIYNLMSQKFRA

>TSHR_homSap Homo sapiens (human) thyrotropin receptor 1 exon PM:20305779 
VWFVSLLALLGNVFVLLILLTSHYKLNVPRFLMCNLAFADFCMGMYLLLIASVDLYTHSEYYNHAIDWQTGPGCNTAGFFTVFASELSVYTLTVITLERWYAITFAMRLDRKIRLRHACAIMVGGWVCCFLL
ALLPLVGISSYAKVSICLPMDTETPLALAYIVFVLTLNIVAFVIVCCCYVKIYITVRNPQYNPGDKDTKIAKRMAVLIFTDFICMAPISFYALSAILNKPLITVSNSKILLVLFYPLNSCANPFLYAIFTKAFQR

>ADRB2_homSap Homo sapiens (human) beta2 adrenoceptor pdb:2R4R  PUR Ralpha class 1 exon
MSLIVLAIVFGNVLVITAIAKFERLQTVTNYFITSLACADLVMGLAVVPFGAAHILMKMWTFGNFWCEFWTSIDVLCVTASIETLCVIAVDRYFAITSPFKYQSLLTKNKARVIILMVWIVSGLTSFLPIQMHWYRATHQEAINCYAN
ETCCDFFTNQAYAIASSIVSFYVPLVIMVFVYSRVFQEAKRQLQKIDKSEGRFHVQNLSQVEQDGRTGHGLRRSSKFCLKEHKALKTLGIIMGTFTLCWLPFFIVNIVHVIQDNLIRKEVYILLNWIGYVNSGFNPLIYCRSPDFRI

>ADORA2A_homSap Homo sapiens (human) beta2 adenosine receptor pdb:3EML PUR Ralpha class 2 exons 144-21
  ELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFAITISTGFCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLR 2
1 YNGLVTGTRAKGIIAICWVLSFAIGLTPMLGWNNCGQPKEGKNHSQGCGEGQVACLFEDVVPMNYMVYFNFFACVLVPLLLMLGVYLRIFLA
ARRQLKQMESQPLPGERARSTLQKEVHAAKSLAIIVGLFALCWLPLHIINCFTFFCPDCSHAPLWLMYLAIVLSHTNSVVNPFIYAYRIREFRQ

>ADRB1_melGal Meleagris gallopavo (turkey) beta1 adrenergic receptor pdb:2VT4 1 exon
MALVVLLIVAGNVLVIAAIGSTQRLQTLTNLFITSLACADLVVGLLVVPFGATLVVRGTWLWGSFLCELWTSLDVLCVTASIETLCVIAIDRYLAITSPFRYQSLMTRARAKVIICTVWAISALVSFLPIMMHWWRD
EDPQALKCYQDPGCCDFVTNRAYAIASSIISFYIPLLIMIFVALRVYREAKEQIRKIDRASKRKRVMLMREHKALKTLGIIMGVFTLCWLPFFLVNIVNVFNRDLVPDWLFVAFNWLGYANSAMNPIIYCRSPDFRK

>UROPS1_triAdh Trichoplax adhaerens (trichoplax) XM_002114542 ends trimmed 1 exon
YSVLSLITILGNMLVFLTFYKHASLRTTSNLFIINLAITDLLTGGIKDTLFIYGLTSYNWPKSAILCSFVGFINCVCYVATVYTLTVIAVFRYLAIVCNLGRKIKRKHSILTIACVWIYSSACCLMPIIGWSRY
IYEPTECTCVRSLDKKYYSYTIYILVADFLLPLSVVSFCYGNIFAKMKRNHHHIKRDLSDGQKLDVAEKLSRREEIVARRMFIILAEHVVCFLPYTIIVTMLAANGVDIEPVWYFIVGYLLNLNSALNPVTYIVVNPRLKK

>UROPS2_triAdh Trichoplax adhaerens (trichoplax) XM_002112401 ends trimmed 2 exons 241-21 ?
0 MTLFMLMSCIGNGAVLLVLRYHHDDIKSASNYFITNLALTDFLLGVLCMPCILISCLNGQWVFGQTLCSLTGFANSFFCINSMITLAAVSVEKYCAIASPLTY
HHYMSKSKVTCVISIIWIHSAINASLPFLGWGEYVYLPFETICTVAWWSFPNYVGFIVGINFGLPTVIMSCTYFLILKIARKHSRRIGVST 2
1 RRIHYKTHIKATLMLLIVIGSFIVCWLPHLISMIYLTIYEISPLPCSFHQITTWLAMANSAFNPIIYGAMDTSIRK

See also: LWS | Encephalopsins | Melanopsins | Neuropsin | Peropsin | RGR phyloSNPs | Update Blog