User:Chris Lau

From genomewiki
Jump to navigationJump to search

University of California, San Francisco Prepared 6/14/2011

CURRICULUM VITAE

Name: Yun-Fai Chris Lau

Position: Professor, Step IV Department of Medicine School of Medicine, 1988-present

Member Cancer Genetics Program, Cell Cycle Dysregulation Program and Uro-Oncology Program, Helen Diller Family Cancer Center-UCSF

Institute for Human Genetics - UCSF

Research Career Scientist (GS15-07), Veterans Affairs Medical Center, San Francisco

Address: Room 12-114, Box VAMC-111C5 VA Medical Center 4150 Clement Street University of California, San Francisco San Francisco, CA 94121-1545

Voice: (415) 379-5526 Facsimile: (415) 750-6633 Email: chris.lau@ucsf.edu Website: http://labs.medicine.ucsf.edu/chrislau/

EDUCATION:

1971-73 Harpur College, State University of New York B.A. Chemistry Binghamton, NY 1973-76 Graduate School of Biomedical Sciences M.S. Cell Biology University of Texas Health Sciences Center Houston, TX 1976-79 Graduate School of Biomedical Sciences Ph.D. Cell Biology University of Texas Health Sciences Center Houston, TX 1979-82 University of California, San Francisco Postdoctoral Fellow Yuet Wai Kan, M.D., Mentor (Giannini Foundation)


PRINCIPAL POSITION HELD:

1982-84 University of California, San Francisco Assistant Res. Biochemist Medicine 1984-90 University of California, San Francisco Assistant Professor Physiology 1988-92 University of California, San Francisco Assistant Professor Medicine 1992-01 University of California, San Francisco Associate Professor Medicine 2001-now University of California, San Francisco Professor Medicine


OTHER POSITONS HELD CURRENTLY:

1984-90 Howard Hughes Medical Institute Associate Investigator 1991-2003 Transgenic Mouse Laboratory Director VAMC-UCSF 1991-now VA Medical Center, San Francisco Member Cardiology Section 1991-now Division of Developmental & Cell Genetics Director VAMC-UCSF 1994-now Department of Veterans Affairs Research Career Scientist (GS15-06)

HONORS AND AWARDS

1974-76 Robert A. Welch Fellowship, University of Texas at Houston 1976-79 Rosalie B. Hite Fellowship, University of Texas at Houston 1979-82 Giannini Postdoctoral Fellowship, University of California, San Francisco 1985 Visiting Professor, Japan Academy, Tokyo, Japan 1992,1996 Visiting Professor, Academy of Natural Sciences of Argentina, Buenos Aires, Argentina 2001, 2004 Visiting Professor, Institute of Medical Genetics, Children's Hospital, Shanghai, China

KEYWORDS/AREAS OF RESEARCH INTERESTS

Molecular genetics, Y chromosome genes, sex determination and differentiation, testicular germ cell tumors, gonadoblastoma, prostate cancer, sexual dimorphisms, transcription complexes, protein-protein interaction, epigenome, genomics, next generation sequencing, neurodevelopment, autism, cognitive disorders, transgenic mouse models of human diseases

PROFESSIONAL ACTIVITIES

SCIENTIFIC REVIEW ACTIVITIES

Scientific Journals: Ad Hoc Referee (past 3 years)

American Journal of Human Genetics BMC Developmental Biology BBA Gene Structure and Expression Molecular Biology of the Cell Carcinogenesis Journal of Genetics and Genomics Genome Research Human Pathology Journal of Biological Chemistry Physiological Genomics Lancet Oncology Journal of Histochemistry and Cytochemistry Prenatal Diagnosis Molecular Cancer Cancer Epidemiology Biology of Reproduction Asian Journal of Andrology British Journal of Cancer

External Referees: Ad Hoc Reviewer (past 3 years)

Mayo Clinic, Rochester, Faculty Promotion National Institute for Child Health and Human Development, staff promotion, 3 times University of California, Irvine, Faculty promotion University of Southern Alabama, Faculty promotion


Grant Applications: Ad Hoc Reviewer (past 3 years)

Research Grant Council, Hong Kong Welcome Trust of United Kingdom Medical Research Council, Great Britain National Science Foundation Telethon Fondazione, Italy

Editorial Boards

2009-now Journal of Genetics and Genomics Editorial Board Member 2009-now Genes Editorial Board Member 2010-now Cell and Bioscience Editorial Board Member

UNIVERSITY SERVICE:

Ad Hoc Consultant/Member Pediatric Endocrinology Clinic, occasional occurrence Clinical Cytogenetics Laboratory, 1984 – 1990 Faculty Promotion Committees/Evaluation (7 times for the past 3 years)

GOVERNMENT AND OTHER PROFESSIONAL SERVICE

National Institutes of Health 1987 Biochemistry Study Section 2 Study Section Member 1989-90 Special Study Section 2 (Human Genome) Study Section Member 1990-94 Medical Biochemistry Study Section Chartered Member 1997 Site Visit Team, National Institute of Child Health Team Member and Human Development 2000-01 Biological Sciences 1 Study Section Study Section Member 2004, 2009 Special Review Panel, National Institute on Drug Abuse Panel Member

American Heart Association, California Affiliate

1993-94 North Peer Review Subcommittee Study Section Member

National Research Council

1994-96 Predoctoral Fellowship in Biological Sciences Study Section Member National Research Council-Howard Hughes Medical Institute

National Science Council, Taiwan

2005-2009 National Research Program for Genomic Medicine Study Section Member

National Health Research Institutes, Taiwan

2006-present General Medicine Study Section 1 Study Section Member

National Taiwan University, Taipei, Taiwan

2006-2008 Excellent Research Projects Reviewer & Site Visit Team

Faculty of Medicine, Chinese University of Hong Kong, China

2009-2011 First Professional Examination External Examiner 2010 Doctoral Thesis Committee External Examiner


Veterans Affairs Medical Center, San Francisco (Local)

1994-03 BioSafety Subcommittee Member 1998-02 Equipment Subcommittee Chair 2001-2004 Animal Care Subcommittee Member 2002-2005 Research and Development Committee Member 2005-present Research Subcommittee Member 2007-present Equipment Workgroup Chair

Department of Veterans Affairs, Medical Research Service (National)

1999-01 National Equipment Committee Review Panel Member 2001-02 Infrastructure Survey Team (scientific & administration) Scientist Member 2003-05 General Medicine Review Panel Panel Member 2009-present Cellular and Molecular Medicine Review Panel Panel Member

PROFESSIONAL ORGANIZATIONS

American Association for the Advancement of Science American Society for Cell Biology American Society of Human Genetics Association of Chinese Geneticists in America (Director, 1990 - 1993; President, 1999-2000; 

 		Nomination Committee, 2000-03; Award Committee, Chair, 2003-04 & 2008, Advisory 			Committee, 2007-09)

Society of Chinese Bioscientists in America (SCBA), Secretary, 2008-2009 Council Member, 2010-present Award Committee, 2006 - Member, 2009 - Chair Co-Editor, SCBA Newsletter, a quarterly electronic publication Webmaster, Society Website, http://www.SCBAsociety.org/

INVITED PRESENTATIONS

Selected Lectureship and Speaker in International Conferences (2003-present) • Third International Symposium on Vertebrate Sex Determination, Kona, Hawaii, 2003 • 10th International Symposium of SCBA, Session Chair and Speaker on Workshop on Y 

        chromosome in Evolution, Population & Molecular Genetics, Beijing, China, 2004

• The Institute of Medical Genetics, Shanghai Jiaotong University, 2004 • Life Science Conference, Wuhan, China, 2004 • American Society of Human Genetics, 2 platform presentations, Toronto, Canada, 2004 • McGill University, Montreal, Canada, 2004 • Consortium on Testicular Germ Cell Tumors, London, England, 2004 • International Symposium on Genomic Medicine, Shanghai, China, 2005 • International Conference on Y Chromosome and Male Germ Cell Biology, Pacific Grove, California, 2005. • Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan, 2006 • 11th International Symposium of SCBA, San Francisco, California, 2006 • China Medical University, Tainan, Taiwan, 2006 • International Congress of Global Chinese Geneticists, Beijing, China, 2006 • Mito2006 International Conference, Speaker & Session Chair, Wenzhou, China, 2006 • American Society of Human Genetics, platform presentation, San Diego, California, 2007 • Innovative Minds in Prostate Cancer Today, Atlanta, Georgia, 2007 • International Conference on Genetic and Genomic Medicine, Speaker & Session Chair, Hong Kong, 2008 • Institute of Human Genetics, Hannover Medical University, Hannover, Germany, 2009 • Liver Center, University of Kansas, Kansas City, 2009 • 12th International Symposium of SCBA, Taipei, Taiwan, 2009 • Department of Biochemistry, Chinese University of Hong Kong, 2009 • Invited Speaker, Utah/Florence Conference on Genetics of Male Infertility, Park City, Utah, 2010 • Invited Speaker, Genomic Medicine Conference, Taipei, Taiwan, 2010 • Invited Speaker, School of Biomedical Sciences, Chinese University of Hong Kong, 2010 • Invited Speaker, Zhangshan School of Medicine, Sun Yat-sen University, Guangzhou, China, 2010 • Invited Speaker and Session Chair, 9th Asia-Pacific Conference on Human Genetics, Hong Kong, 2010 • Invited Speaker, Center for Developmental Biology, Wuhan University, China, 2010 • Invited Lecturer, Program in Reproductive Endocrinology, Chinese University of Hong Kong, 2011 • Session Chair and Invited Speaker, 13th International Symposium of SCBA, Guangzhou, 2011


Organizer of International Meetings and Conferences (2005 – present) • International Symposium on Genomic Medicine, Member of Organizing Committee, Speaker and Session Chair, Shanghai, China, 2005 • First International Conference on Y Chromosome, Male Germ Cell Biology, and Reproduction in the Post Genomic Era, Co-Organizer, Session Chair and Speaker, Asilomar, California, 2005 • 11th International Symposium of SCBA, San Francisco, Co-Chair, Local Organizing Committee, 2006 • International Conference on Genetic and Genomic Medicine, Hong Kong, Scientific Advisory Committee, 2008. • 12th International Symposium of SCBA, Taipei, Secretary and Organizing Team, 2009


PEER-REVIEWED PUBLICATIONS

1. Lau Y-F, Hittelman WN and Arrighi FE (1976). Sister chromatid differential staining pattern in prematurely condensed chromosomes. Experientia, 32:917-919.

2. Lau Y-F and Arrighi FE (1976). Studies of the squirrel monkey, Saimiri sciureus, genome I: Cytological characterizations of chromosomal heterozygosity. Cytogenet Cell Genet, 17:51-60.

3. Lau Y-F, Arrighi FE and Chuang CR (1977). Studies of the squirrel monkey, Saimiri sciureus, genome II: C-banding characterization and DNA replication patterns. Cytogenet Cell Genet, 19:14-25.

4. Lau Y-F, Brown RL and Arrighi FE (1977). Induction of premature chromosome condensation in CHO cells fused with polyethylene glycol. Exp Cell Res, 110:57-61.

5. Lau Y-F and Hsu TC (1977). Variable modes of Robertsonian fusion. Cytogenet Cell Genet, 19:231-236.

6. Lau Y-F, Pfeiffer RA, Arrighi FE and Hsu TC (1978). Combination of silver and fluorescent staining for metaphase chromosomes. Am J Hum Genet, 30:76-79.

7. Lau Y-F, Wertelecki W, Pfeiffer RA and Arrighi FE (1979). Cytological analyses of a 14p+ variant using N-banding and combinations of silver staining and chromosome bandings. Hum Genet, 46:75-82.

8. Pathak S, Lau Y-F and Drwinga HL (1979). Observations on the synaptonemal complex in Armenian hamster spermatocytes by light microscopy. Chromosoma, 73:53-60.

9. Barker PE, Lau Y-F and Hsu TC (1980). A heterochromatic homogeneously staining region (HSR) in the karyotype of a human carcinoma cell line. Cancer Genet Cytogenet, 1:311-319.

10. Arrighi FE, Lau Y-F and Spallone PA (1980). Nucleolar activities in differentiated cells after stimulation. Cytogenet Cell Genet, 26:244-250.

11. Lau Y-F and Arrighi FE (1980). Studies of mammalian chromosome replication I: BrdU-induced differential staining patterns in interphase and metaphase chromosomes. Cytogenet Cell Genet, 27:176-183.

12. Hubell HR, Lau Y-F, Brown RL and Hsu TC (1980). Cell cycle analysis and drug inhibition studies of silver staining in synchronous HeLa cells. Exp Cell Res, 129:139-147.

13. Lau Y-F and Arrighi FE (1981). Studies of mammalian chromosome replication II: Evidence for the existence of defined chromosome replicating units (chromosomal replicons). Chromosoma, 83:721-741.

14. Lau Y-F (1983). Studies of mammalian chromosome replication III: Organization and replication of diplochromosomes. Exp Cell Res, 146:445-450.

15. Lau Y-F and Kan YW (1983). Versatile cosmid vectors for the isolation, expression and rescue of gene sequences: Studies with the human α-globin gene cluster. Proc Natl Acad Sci USA, 80:5225-5229.

16. Lau Y-F and Kan YW (1984). Direct isolation of the functional human thymidine kinase gene with a cosmid shuttle vector. Proc Natl Acad Sci USA, 81:414-418.

17. Lau Y-F, Huang JC, Dozy AM and Kan YW (1984). A rapid screening test for antenatal sex determination. Lancet, i:14-16.

18. Lau Y-F, Lin CC and Kan YW (1984). Amplification and expression of human α-globin genes in Chinese hamster ovary cells. Mol Cell Biol, 4:1469-1475.

19. Lau Y-F and Schonberg S (1984). A male-specific DNA probe detects heterochromatin sequences in a familial Yq- chromosome. Am J Hum Genet, 26:1394-1396.

20. Lau Y-F, Ying KL and Donnell GN (1985). Identification of a case of Y:18 translocation using a Y-specific repetitive DNA probe. Hum Genet, 69:102-105.

21. Lau Y-F (1985). Detection of Y-specific repeat sequences in normal and variant human chromosomes using in situ hybridization with biotinylated probes. Cytogenet Cell Genet, 39:184-187.

22. Reardon CA, Lau Y-F, Paik Y-K, Weisgraber KH, Inneararity TL, Mahley RW and Taylor JM (1986). Expression of the human apolipoprotein E gene in cultured mammalian cells. J Biol Chem, 261:9858-9864.

23. Choo KH, Filby G, Greco S, Lau Y-F and Kan YW (1986). Cosmid vectors for high efficiency DNA-mediated transformation and gene amplification in mammalian cells: Studies with the human growth hormone gene. Gene, 46:277-286.

24. Lau Y-F and Li CH (1987). Localization of α-inhibin-31 in rodent testis and brain by immunocytochemical procedure and Western blot analysis. Biochem Biophys Res Com, 145:81-89.

25. Boer PH, Adra CN, Lau Y-F and McBurney MW (1987). The testis-specific phosphoglycerate kinase gene, pgk-2, is a recruited retroposon. Mol Cell Biol, 7:3107-3112.

26. Manavathu EK, Suryanarayana K, Hasnain SE, Leung M, Lau Y-F and Leung W-C (1987). Expression of Herpes simplex virus thymidine kinase gene in aquatic filamentous fungus Achlya ambisexualis. Gene, 57:53-59.

27. Wu KC, Chan K, Lee Y-CG and Lau Y-F (1987). Molecular isolation and sequence determination of the cDNA for the mouse sperm-specific lactate dehydrogenase-X gene. Biochem Biophys Res Com, 146:964-970.

28. Bray PF, Rosa J-P, Johnston GI, Shiu DT, Cook RG, Lau Y-FC, Kan YW, McEver RP and Shuman MA (1987). Platelet glycoprotein IIb, chromosomal localization and tissue expression. J Clin Invest, 80:1812-1817.

29. Tagawa M, Ito T, Kanno M, Okitsu A, Imai K, Kuwabara I, Koseki H, Matsubara H, Lau Y-F and Taniguchi M (1988). Method of genomic DNA cloning by the combination of cosmid shuttle vector and monoclonal antibody. Microbiol Immunol, 32:1073-1078.

30. Kim YK, Wells S, Lau Y-F and Lee AS (1988). Sequences contained within the promoter of the human thymidine kinase gene can direct cell cycle regulation of heterologous fusion genes. Proc Natl Acad Sci USA, 85:5894-5898.

31. Okitsu A, Tagawa M, Tamura Y, Kanno M, Matsubara H, Ito T, Imai K, Shigemoto K, Nakamura I, Koseki H, Lau Y-F and Taniguchi M (1988). Isolation of genomic DNA controlling mouse melanoma antigen defined by monoclonal antibody. Jpn J Cancer Res, 79:718-725.

32. Kao F-T, Wu KC, Law ML, Hartz JA and Lau Y-F (1988). Assignment of the human gene encoding testis-specific lactate dehydrogenase C to chromosome 11, region p14.3-p15.1. Somat Cell Mol Genet, 14:515-518.

33. Nagamine CM, Chan K, Kozak CA and Lau Y-F (1989). Chromosome mapping and expression of a putative testis-determining gene in mouse. Science, 243:80-83.

34. Gross MS, Sefiani A, de Tand MF, Lau Y-F, Saidi-Mehtar N, Hors-Cayla MC, Frezal J, Van Cong N (1989). The anonymous PAS45 probe detects RFLPs in 13q31. Ann Genet, 32:73-77.

35. Poole S, Law ML, Kao F-T and Lau Y-F (1989). Isolation and chromosomal localization of the human En-2 gene. Genomics, 4:225-231.

36. Lau Y-FC, Chan K and Sparkes R (1989). Male-enhanced antigen gene is phylogenetically conserved and expressed at late stages of spermatogenesis. Proc Natl Acad Sci USA, 86:8462-8466.

37. Lau Y-FC and Chan K (1989). The putative testis-determining factor and related genes are expressed as discrete-sized transcripts in adult gonadal and somatic tissues. Am J Hum Genet, 45:942-952.

38. Nagamine CM, Chan K, Hake LE and Lau Y-FC (1990). The two candidate testis-determining Y genes (Zfy-1, Zfy-2) are differentially expressed in fetal and adult mouse tissues. Gene & Devel, 4:63-74.

39. Jen J, Deschepper CF, Shackleford GM, Lee CYG and Lau Y-FC (1990). Stage-specific expression of the lactate dehydrogenase-X gene in adult and developing mouse testes. Mol Reprod Devel, 2:14-21.

40. Liu M-S, Chan K, Lau Y-FC and Lee C-YG (1990). Molecular cloning of an acrosomal sperm antigen gene and the production of its recombinant protein for immunocontraceptive vaccine. Mol Reprod Devel, 2:302-308.

41. Leung WY, Lindgren V, Lau Y-FC and Yang-Feng TL (1990). Regional assignment of the zinc finger Y-linked genes (ZFY and related sequences) on human and mouse chromosomes. Cytogenet Cell Genet, 54:151-153.

42. Lau Y-FC, Yang-Feng TL, Elder B, Fredga K and Wiberg U (1992). Unusual distribution of Zfy and Zfx sequences on the sex chromosomes of the wood lemming, a species with XY sex reversal. Cytogenet Cell Genet, 60:48-54.

43. Su H, Kozak CA, Veerhuis R, Lau Y-FC and Wiberg U (1992). Isolation of a phylogenetically conserved and testis-specific gene using a monoclonal antibody against the serological H-Y antigen. J Reprod Immunol, 21:275-291.

44. Nagamine CM, Nishioka Y, Moriwaki K, Boursot P, Bonhomme F and Lau Y-FC (1992). The musculus-type Y chromosome of the laboratory mouse is of Asian origin. Mam Genome, 3:84-91.

45. Su H and Lau Y-FC (1992). Demonstration of a stage-specific expression of the ZFY protein in fetal mouse testis using anti-peptide antibodies. Mol Reprod Devel, 33:252-258.

46. Zhang JS, Yang-Feng TL, Muller U, Mohandas TK, De Jong PJ and Lau Y-FC (1992). Molecular isolation and characterization of an expressed gene from the human Y chromosome. Hum Mol Genet, 1:717-726.

47. Su H and Lau Y-FC (1993). Identification of the transcriptional unit, structural organization and promoter sequence of the human sex determining region (SRY) gene using a reverse genetic approach. Am J Hum Genet, 52:24-38.

48. Boissonneault G and Lau Y-FC (1993). A testis-specific gene encoding a nuclear HMG box protein located in the elongating spermatids. Mol Cell Biol, 13:4323-4330.

49. Coward P, Nagai K, Chen D, Thomas HD, Nagamine CM and Lau Y-FC (1994). Polymorphism of a CAG trinucleotide repeat within Sry correlates with B6.YDom sex reversal. Nature Genetics, 6:245-250.

50. Affara NA, Lau Y-FC, Briggs H, Davey P, Jones MH, Khaja O, Mitchell M and Sargent C (1994). Report of the first international workshop on Y chromosome mapping 1994. Cytogenet Cell Genet, 67:245-250.

51. Dubin RA, Coward P, Lau Y-FC and Ostrer H (1995). Functional comparison of the Mus molossinus and Mus musculus domesticus Sry genes. Mol Endocrin, 9:1645-1654.

52. Affara N., Bishop C, Brown W, Cooke H, Davey P, Ellis N, Graves JM, Jones M, Mitchell M, Rappold G, Tyler-Smith C, Yen P and Lau Y-FC (1996). Report of the second international workshop on Y chromosome mapping 1995. Cytogenet Cell Genet, 73:33-76.

53. Diatchenko L, Lau Y-FC, Campbell AP, Chenchik A, Moqadam F, Huang B, Lukyanov S, Lukyanov K, Gurskaya N, Sverdlov ED and Siebert PD (1996). Suppression subtractive hybridization: A method for generating differentially regulated or tissue-specific cDNA probes and libraries. Proc Natl Acad Sci USA, 93:6025-6030.

54. Liou J-D, Ma Y-Y, Gibson L, Su H, Charest N, Lau Y-FC and Yang-Feng TL (1997). Cytogenetic and molecular studies of a familial paracentric inversion of Y chromosome present in a patient with ambiguous genetalia. Am J Med Genet, 70:134-137

55. Shimamura R, Fraizer GC, Trapman J, Lau Y-FC and Saunders GF (1997). The Wilms’ tumor gene WT1 can regulate genes involved in sex determination and differentiation: SRY, Müllerian-inhibiting substance, and the androgen receptor. Clin Cancer Res, 3:2571-2580.

56. Vogt PH, Afar N, Davey P, Hammer M, Jobling M, Lau Y-FC, Mitchell M, Schempp W, Tyler-Smith C, Williams G, Yen P and Rappold GA (1997). Report of the third international workshop on Y chromosome mapping 1997. Cytogenet Cell Genet, 79:1-20.

57. Lau Y-FC and Zhang JQ (1998). SRY interactive proteins: Implication for the mechanisms of sex determination. Cytogenet Cell Genet, 80:128-132.

58. Zhang JQ, Coward P, Xian MW and Lau Y-FC (1999). Interactive proteins to the mouse Sry glutamine-rich domain are differentially expressed in adult and fetal tissues. Int J Dev Bio, 43:219-227.

59. Xian MW, Honbo N, Zhang JQ, Liew CC, Karliner JS and Lau Y-F C (1999). The green flourescent protein is an efficient biological marker for cardiomyocytes. J Mol Cell Card, 31:2155-2165.

60. Lau Y-FC and Zhang JQ (2000). Expression analysis of thirty-one Y chromosome genes in prostate cancer. Mol Carcin, 27:308-321.

61. Karliner JS, Honbo N, Epstein CJ, Xian M, Lau Y-FC and Gray MO (2000). Neonatal mouse cardiac myocytes exhibit cardioprotection induced by hypoxic and pharmacoligic pre-conditioning and by transgnic overexpression of human Cu/Zn superoxide dismutase. J Mol Cell Cardiol, 32:1779-1786.

62. Lau Y-FC, Chou PM, Iezzoni J, Alonzo J and Kömüves LG (2000). Expression of a candidate for gonadoblastoma locus in gonadoblastoma and testicular seminoma. Cytogenet Cell Genet, 160-164.

63. Xian MW, Zhang JQ and Lau Y-FC (2001). The Sry promoters from domesticus (Tirano) and C57BL/6 mice function similarly in embryos and adult animals. J Exp Zoo, 290:632-641.

64. Liu WS, K Nordqvist, Lau Y-FC and Fredga K (2001). Characterization of the Xp21-23 region in the wood lemming, a region involved in XY sex reversal. J Exp Zoo, 290:551-557.

65. Kren V, Qi N, Krenova D, Zidek V, Sladka M, Jachymova M, Mikova B, Horky K, Bonne A, Van Lith HA, Van Zutphen BFM, Lau Y-FC, Pravenec M and St. Lezin E (2001). Transfer of chromosome Y from the brown Norway rat into the spontaneously hypertensive rat induces significant reduction in blood pressure and dyslipidemia. Hypertension, 37:1147-1152.

66. Lau Y-FC, Lau HW and Kömüves LG (2003). Expression pattern of a gonadoblastoma candidate gene suggests a role of the Y chromosome in prostate cancer. Cytogenet Genome Research, 101:250-260.

67. Li YM, Yue LL, Taketo T and Lau Y-FC (2003). Protein transduction as a strategy for evaluating important factors in mammalian sex determination and differentiation. Cytogenet Genome Research, 101:237-241.

68. Honecker F, Stoop H, de Krijger R, Lau Y-FC, Castrillon D, Oosterhuis JW, Bokemeyer and Looijenga LHJ (2004). Pathological implications of the expression of markers of testicular carcinoma in situ by fetal germ cells. J Pathol, 203:849-857.

69. Oh HJ, Li YM and Lau Y-FC (2005). Sry associates with a gene-silencing complex by interacting with a KRAB domain protein. Biol Reprod, 72:407-415.

70. Taketo T, Lee C-H, Zhang JQ, Li YM, Lee G and Lau Y-FC (2005). Expression of Sry proteins in both normal and sex-reversed XY fetal mouse gonads. Devel Dyn, 233:612-622.

71. Williams K, Fernandex S, Stien X, Ishii K, Love HD, Lau Y-FC, Roberts RL and Hayward SW (2005). Unopposed c-MYC expression in benign prostatic epithelium causes a cancer phenotype. The Prostate, 63:369-384.

72. Kido T and Lau Y-FC (2005). The promoter of the putative GBY gene on the Y chromosome is capable of directing a transgene expression in female mouse germ cells. Genesis, 42:263-275.

73. Kersemaekers AM, Honecker F, Stoop H, Cools M, Molier M, Wolffenbuttel K, Bokemeyer C, Li Y, Lau Y-FC, Oosterhuis JW, Looijenga LH (2005). Identification of germ cells at risk for neoplastic transformation in gonadoblastoma: an immunohistochemical study for OCT3/4 and TSPY. Hum Pathol, 36:512-21.

74. Honecker F, Stoop H, Mayer F, Bokemeyer C, Castrillon DH, Lau Y-FC, Looijenga LH, Oosterhuis JW (2006). Germ cell lineage differentiation in non-seminomatous germ cell tumours. J Pathol, 208:395-400.

75. Oh HJ, Lau Y-FC (2006). KRAB: A partner for SRY action on chromatin. Mol Cell Endocrinol, 247:47-52.

76. Cools M, Honecker F, Stoop H, Veltman JD, de Krijger RR, Steyerberg E, Wolffenbuttel KP, Bokemeyer C, Lau Y-FC, Drop SL, Looijenga LH (2006). Maturation delay of germ cells in fetuses with trisomy 21 results in increased risk for the development of testicular germ cell tumors. Hum Pathol. 37:101-11.

77. Hoei-Hansen C, Sehested A, Juhler M, Lau Y-FC, Skakkebaek NE, Laursen H and Rajpert De Meyts E (2006). New evidence for the origin of intracranial germ cell tumours from primordial germ cells: expression of pluripotency and cell differentiation markers. J Path, 209:25-33.

78. Oram SW, Liu XX, Lee T-L, Chan WY and Lau Y-FC (2006). TSPY potentiates cell proliferation and tumorigenesis by promoting cell cycle progression in HeLa and NIH3T3 cells. BMC Cancer, 6: 154.

79. Vong QP, Li Y, Lau Y-FC, Dym M, Rennert OM, Chan WY (2006). Structural characterization and expression studies of Dby and its homologs in the mouse. J Andrology, 27:653-661.

80. Li YM, Oh HJ and Lau Y-FC (2006). Poly(ADP-ribose) polymerase I interacts with Sry and modulates its biological activities. Mol Cell Endocrin, 257-258:35-46.

81. Kido T and Lau Y-FC (2006). The rat Tspy is preferentially expressed in elongated spermatid and interacts with core histones, Biochem Biophys Res Comm, 250:56-67.

82. Li YM, Vilain E, Conte F, Rajpert-De Meyts E and Lau Y-FC (2007). TSPY is expressed in early and late stages of gonadoblastoma and testicular carcinoma-in-situ. Urol Oncol, 25:141-146 .

83. Oh HJ, Kido T and Lau Y-FC (2007). PIAS1 interacts with and represses SOX9 transactivation activity. Mol Reprod Develop, 74:1446-55.

84. Li YM, Tabatabi ZL, Lee T-L, Hatakeyama S, Ohyama C, Chan W-Y, Looijenga LH and Lau Y-FC (2007). The Y-encoded TSPY protein: a significant marker potentially plays a role in the pathogenesis of testicular germ cell tumors, Human Pathology, 38:1470-81.

85. de Jong J, Stoop H, Gillis AJ, van Gurp RJ, van Drunen E, Beverloo HB, Lau Y-FC, Schneider DT, Sherlock JK, Baeten J, Hatakeyama S, Ohyama C, Oosterhuis JW, Looijenga LH. (2007). JKT-1 is not a human seminoma cell line. Int J Andrology, 30:350-65.

86. Cools M, Boter M, van Gurp R, Stoop H, Poddighe P, Lau Y-FC, Drop SL, Wolffenbuttel KP, Looijenga LH. (2007). Impact of the Y-containing cell line on histological differentiation patterns in dysgenetic gonads. Clinical Endocrin, 67:184-92.

87. Kido T and Lau Y-FC (2008). The human Y-encoded testis-specific protein interacts functionally with the translation elongation factor 1A, Int J Cancer, 123:1573-85.

88. Li YM and Lau Y-FC (2008). TSPY and its X-encoded homologue interact with cyclin B but exert contrasting functions on cyclin dependent kinase 1 activities, Oncogene, 27:6141-50.

89. Li YM, Kido T, Luo S, Dobrinski I, and Lau Y-FC (2008). Intratubular transplantation as a strategy for establishing animal models of testicular germ cell tumors. Int J Exp Path, 89:342-349.

90. Lau Y-FC and Li YM (2009). The human and mouse sex-determining SRY genes repress the Rspo1/β-catenin signaling. J Genet Genomics, 36:193-202.

91. Lee TL, Li YM, Alba D, Vong QP, Wu SM, Baxendale V, Rennert OM, Lau Y-FC, Chan WY. (2009). Developmental staging of male murine embryonic gonad by SAGE analysis. J Genet Genomics, 36:215-27.

92. Wu JB, Chen K, Li YM, Lau Y-FC and Shih JC (2009). Regulation of monoamine oxidase A by the SRY gene on the Y chromosome. FASEB J, 23:4029-38..

93. Peng H, Ivanov AV, Oh HJ, Lau Y-FC and Rauscher III FJ (2009). Epigenetic gene silencing by the SRY protein is mediated by a KRAB-O protein which recruits the KAP1 co-repressor machinery. J Biol Chem, 284:35670-80.

94. Lee TL, Li Y, Cheung HH, Claus J, Singh S, Sastry C, Rennert OM, Lau Y-FC and Chan WY (2010). GonadSAGE: a comprehensive SAGE database for transcript discovery on male embryonic gonad development. Bioinformatics, 26:585-6.

95. Kido T, Hatakeyama S, Ohyama C and Lau Y-FC (2010). Expression of the Y-encoded TSPY is associated with progression of prostate cancer. Genes 1:283-293.

96. Lau Y-FC, Li YM and Kido T (2011). Role of the Y-located putative gonadoblastoma gene in human spermatogenesis. Systems Biol in Reprod Med, 57:27-34.

97. Kido T, Schubert S, Schmidtke J and Lau Y-FC (2011). Expression of the human TSPY gene in the brains of transgenic mice suggests a potential role of this Y chromosome gene in neural functions, J Genetics and Genomics 38:181-192.

98. Pleskacova J, Stoop H, Oosterhuis JW, Cools M, Lau Y-FC, Drop SLS, Snajderova M, Lebl J, and Looijenga LHJ (2011). Defined markers for detection of germ cells at risk for malignant transformation in patients with disorders of sex development, submitted.

99. Kido T, Ou JT-H, Lau Y-FC (2011). The X-linked tumor suppressor TSPX interacts and promotes degradation of the hepatitis B viral protein HBx via the ubiquitin-proteasome pathway, PLOS One, accepted with revision.


MANUSCRIPTS IN PREPARATION

100. Li YM, Zheng M and Lau Y-FC (2011). Identification of the target genes for Sry and Sox9 in mouse fetal gonads during sex determination.

101. Li YM, Garcia-Barcelo M, Lui V, Tam PK and Lau Y-FC (2011). SRY represses TTF-1 transactivation of the RET gene, a major Hirschsprung’s disease gene.

102. Kido T and Lau Y-FC (2011). Contrasting roles of Y-encoded TSPY and X-encoded TSPX in androgen receptor transcriptional regulation.


NON-PEER REVIEWED PUBLICATIONS AND OTHER CREATIVE ACTIVITIES

Invited Review Articles:

1. Lau Y-F, Lin CC and Kan YW (1983). Amplification of the human α-globin gene enhances its expression. Trans Assoc Am Phys, 96:93-102.

2. Lau Y-F (1987). Rescue of genes transfected from cosmid libraries. Meth Enzymol, 151:426-433.

3. Lebo RV, Anderson LA, Lau Y-F, Flandermeyer R and Kan YW (1986). Flow sorting analysis of normal and abnormal human genomes. Cold Spring Harbor Symposia on Quantitative Biology, 51:169-176.

4. Reardon CA, Paik Y-K, Chang DJ, Davies GE, Mahley RW, Lau Y-F and Taylor JM (1986). Cloning and expression of the human apolipoprotein E gene. Meth Enzymol, 128:811-823.

5. Lau Y-F, Chan K, Kan YW and Goldberg E (1988). Male-enhanced expression and genetic conservation of a gene isolated with an anti-H-Y antibody. Trans Assoc Am Phys, 100:45-53.

6. Diatchenko L, Lukyanov S, Lau Y-FC and Siebert PD (1999). Suppression subtractive hybridization: A versatile method for identifying differentially expressed genes. Meth Enzymol, 303:349-380.

7. Lau Y-FC (1999). Gonadoblastoma, testicular and prostate cancers and the TSPY gene. Am J Hum Genet, 64:921-927.

8. Lau Y-FC, Li YM and Kido T (2009). Gonadoblastoma locus and the TSPY gene on the human Y chromosome. Birth Defects Research (Part C) 87:114-122.


Chapters of Books

1. Lau Y-F and Arrighi FE (1977). Comparative studies of N-banding and silver staining of NORs in human chromosomes. In Aspects of Chromosome Organization and Function (ME Drets, N Bram-Zorrila and GA Folle eds), Latin American Association of Genetics Press, Montevideo, pp49-55.

2. Cordell B, Lebo RV, Yu LC, Lau Y-F, Carrano AV and Goodman HM (1980). Structure, evolution and expression of insulin genes. In Sixth International Endocrinology Meetings (Cummings, Funder, Medelsohn eds), Elsevier Press, Amsterdam, pp377-381.

3. Kan YW, Dozy AM and Lau Y-F (1983). Gene transfer as a model for therapy of sickle cell anemia and thalassemia. In Recent Advances in Hematology, Immunology and Blood Transfusion (SR Holland ed), Hungarian Academy of Science Press, Budapest, pp15-23.

4. Lau Y-F (1985). Organization of the human Y-specific HaeIII 3.4 repeat sequences and their application in clinical diagnosis. In The Y Chromosome, Part A: Basic Characteristics of the Y Chromosome (AA Sandberg ed), Alan R. Liss Press, New York, pp177-192.

5. Lau Y-F (1987). Localization of the gene for the male-enhanced antigen on human and mouse chromosomes. In Genetic Markers of Sex Differentiation (FP Haseltine, ME McClure and EH Goldberg eds), Plenum Press, New York, pp161-167.

6. Deschepper CF, Mellon SH, Reudehuber TL, Gardner DG, Jen J and Lau Y-F (1988). In situ hybridization histochemistry on mRNA in endocrine tissues. In Endocrine Genes: Analytical Methods, Experimental Approaches, and Selected Systems (Y-F Lau ed), Oxford University Press, New York, pp31-41.

7. Lau Y-F (1989). Are male-enhanced antigen and serological H-Y antigen the same ? In Evolutionary Mechanisms in Sex Determination (SS Watchel ed), CRC Press, New York, pp151-157.

8. Lau Y-F (1990). The function of H-Y antigen: yes, no and maybe. In Turner Syndrome Symposium (RG Rosenfeld and MM Grumbach eds), Marcel Dekker Press, New York, pp79-86.

9. Vandermark S, Cohen D, Janssens P, Lau Y-FC and Bradley M (1993). Germ cell specific gene expression in a seasonal breeder: the European red fox, Vulpes vulpes. In Sex Determination and Testis Function (K Reed and J Marshall-Graves eds). Harwood Academic Press, Mitcham, Australia, pp 69-85.

10. Nagamine CM, Boursot P, Lau Y-FC and Moriwaki K (1994). Evolution of the Y chromosome in wild mice. In Genetics of Wild Mice: Its Applications to Biomedical Research (K Moriwaki, T Shiroshi and H Yonekawa eds). Japan Science Society Press,Tokyo, pp 41-55.

11. Lau Y-FC, Kido T and Li YM (2007). The TSPY Gene Family. In Y Chromosome and Male Germ Cell Biology (Y-FC Lau and WY Chan, eds). Pp73-90, World Scientific Press, New Jersey. 12. Li YM, Taketo T and Lau Y-FC (2010). Isolation of fetal gonads from embryos of timed pregnant mice for morphological and molecular studies. In Methods in Molecular Biology (WY Chan, ed). Humana Press, New York, in press.


Books

1. Lau Y-F (1988). Editor, Endocrine Genes: Analytical Methods, Experimental Approaches and Selected Systems, Oxford University Press, New York.

2. Lau Y-FC and Chan WY (2007). Editors, Y Chromosome and Male Germ Cell Biology, World Scientific Press, New Jersey.

Retrieved from "https://genomewiki.ucsc.edu/index.php?title=User:Chris_Lau&oldid=16329"