User:Manuel Sanchez Santos

POSSITION Postdocoral Researcher. Department of Nephrology and Hypertension. UMC Utrecth. PROFESSIONAL AND RESEARCH ACTIVITY Most of my research activity has been performed in Pharmacology (3209, Unesco Code), specifically in the fields of Experimental Pharmacology (3209.90) and Natural Medicines (3209.04). My research has been focused on the subjects of endothelial dysfunction due to oxidative stress, its relationship with hypertension, the physiological alterations produced, mainly in the vascular wall and target organs such as heart and kidneys and the study of natural or synthetic drugs able to prevent or revert these changes, as polyphenols and, in recent times, PPAR agonists. Since March 2011 I am working as PostDoc researcher in Dr. Joles’ group at the Universitair Medisch Center (UMC) Utrecht, with a grant of the Ministry of Education of Spain, so currently I am focused on the prevention of hypertension and associated kidney disease with perinatal treatments through the “Reprogramming” of the kidney in the context of the DOHaD hypothesys.

Publications indexed in the Journal Citation Report: 1. Antihypertensive effects of PPARβ activation in spontaneously hypertensive rats. María José Zarzuelo, Rosario Jiménez, Pilar Galindo, Manuel Sánchez, Ana Nieto, Miguel Romero, Ana María Quintela, Rocío López-Sepúlveda, Manuel Gómez-Guzmán, Elvira Bailón, Isabel Rodríguez-Gómez, Antonio Zarzuelo, Julio Gálvez, Juan Tamargo, Francisco Pérez-Vizcaíno, Juan Duarte. Hypertension 2011 Oct;58(4):733-43. 2. Red wine polyphenols prevent endothelial dysfunction induced by endothelin-1 in rat aorta: role of NADPH oxidase. López-Sepúlveda R, Gómez-Guzmán M, Zarzuelo MJ, Romero M, Sánchez M, Quintela AM, Galindo P, O'Valle F, Tamargo J, Pérez-Vizcaíno F, Duarte J, Jiménez R. Clin Sci (Lond). 2011 Apr;120(8):321-33. 3. Vascular superoxide production by endothelin-1 requires Src non-receptor protein tyrosine kinase and MAPK activation. Romero M, Jiménez R, Sánchez M, López-Sepúlveda R, Zarzuelo A, Tamargo J, Pérez-Vizcaíno F, Duarte J. Atherosclerosis. 2010 Sep;212(1):78-85. 4. Endothelium-dependent vasodilator effects of peroxisome proliferator-activated receptor beta agonists via the phosphatidyl-inositol-3 kinase-Akt pathway. Jiménez R, Sánchez M, Zarzuelo MJ, Romero M, Quintela AM, López-Sepúlveda R, Galindo P, Gómez-Guzmán M, Haro JM, Zarzuelo A, Pérez-Vizcaíno F, Duarte J. J Pharmacol Exp Ther. 2010 Feb;332(2):554-61. 5. Quercetin inhibits vascular superoxide production induced by endothelin-1: Role of NADPH oxidase,uncoupled eNOS and PKC. Romero M, Jiménez R, Sánchez M, López-Sepúlveda R, Zarzuelo MJ, O'Valle F,Zarzuelo A, Pérez-Vizcaíno F, Duarte J. Atherosclerosis. 2009 Jan;202(1):58-67. 6. Quercetin ameliorates metabolic syndrome and improves the inflammatory status in obese Zucker rats. Rivera L, Morón R, Sánchez M, Zarzuelo A, Galisteo M. Obesity (Silver Spring). 2008 Sep;16(9):2081-7. 7. Wine polyphenols improve endothelial function in large vessels of female spontaneously hypertensive rats.López-Sepúlveda R, Jiménez R, Romero M, Zarzuelo MJ, Sánchez M, Gómez-Guzmán M, Vargas F, O'ValleF, Zarzuelo A, Pérez-Vizcaíno F, Duarte J. Hypertension. 2008 Apr;51(4):1088-95. 8. Wine polyphenols prevent endothelial dysfunction and vascular superoxide production induced by endothelin-1 in rat aorta. Jimenez R, Lopez-Sepulveda R , Romero M, Zarzuelo MJ, Sanchez M, Gomez-Guzman M,Galindo P, Zarzuelo A , Duarte J. Fundamental & clinical pharmacology 2008 Aug;22(2):81-81. 9. Genistein restores caveolin-1 and AT-1 receptor expression and vascular function in large vessels of ovariectomized hypertensive rats. Vera R, Jiménez R, Lodi F, Sánchez M, Galisteo M, Zarzuelo A, Pérez-Vizcaíno F, Duarte J. Menopause. 2007 Sep-Oct;14(5):933-40. 10. Polyphenols restore endothelial function in DOCA-salt hypertension: role of endothelin-1 and NADPH oxidase. Jiménez R, López-Sepúlveda R, Kadmiri M, Romero M, Vera R, Sánchez M, Vargas F, O'Valle F,Zarzuelo A, Dueñas M, Santos-Buelga C, Duarte J. Free Radic Biol Med. 2007 Aug 1;43(3):462-73. 11. Quercetin and isorhamnetin prevent endothelial dysfunction, superoxide production, and overexpression of p47phox induced by angiotensin II in rat aorta. Sanchez M, Lodi F, Vera R, Villar IC, Cogolludo A, Jimenez R, Moreno L, Romero M, Tamargo J, Perez-Vizcaino F, Duarte J. J Nutr. 2007 Apr;137(4):910-5. 12. Chronic administration of genistein improves endothelial dysfunction in spontaneously hypertensive rats:involvement of eNOS, caveolin and calmodulin expression and NADPH oxidase activity. Vera R, Sánchez M, Galisteo M, Villar IC, Jimenez R, Zarzuelo A, Pérez-Vizcaíno F, Duarte J. Clin Sci (Lond). 2007Feb;112(3):183-91. 13. Identification and characterization of novel angiotensin-converting enzyme inhibitors obtained from goat milk. Geerlings A, Villar IC, Hidalgo Zarco F, Sánchez M, Vera R, Zafra Gomez A, Boza J, Duarte J. J Dairy Sci. 2006 Sep;89(9):3326-35. 14. Quercetin downregulates NADPH oxidase, increases eNOS activity and prevents endothelial dysfunction inspontaneously hypertensive rats. Sánchez M, Galisteo M, Vera R, Villar IC, Zarzuelo A, Tamargo J, Pérez-Vizcaíno F, Duarte J. J Hypertens. 2006 Jan;24(1):75-84. 15. A diet supplemented with husks of Plantago ovata reduces the development of endothelial dysfunction, hypertension, and obesity by affecting adiponectin and TNF-alpha in obese Zucker rats. Galisteo M, Sánchez M, Vera R, González M, Anguera A, Duarte J, Zarzuelo A. J Nutr. 2005 Oct;135(10):2399-404. 16. Soy isoflavones improve endothelial function in spontaneously hypertensive rats in an estrogen-independent manner: role of nitric-oxide synthase, superoxide, and cyclooxygenase metabolites. Vera R, Galisteo M, Villar IC, Sánchez M, Zarzuelo A, Pérez-Vizcaíno F, Duarte J. J Pharmacol Exp Ther. 2005 Sep;314(3):1300-9.