User:Susanne Mandrup

Current working place and contact information: Department of Biochemistry and Molecular Biology, University of Southern Denmark (SDU) Campusvej 55, 5230 Odense Telephone: +45 6550 2340 E-mail: s.mandrup@bmb.sdu.dk

Education 1988 Cand. Scient degree in Molecular Biology. 1992 PhD degree in Biochemistry.

Professional experience 1992-95 Post doctoral fellow at the Department of Biochemistry and the Department of Molecular Biology, SDU 1995-96 Post doctoral fellow in Prof. M. Daniel Lane’s lab, Johns Hopkins University, Baltimore, USA 1996-1999 Assistant Professor Department of Molecular Biology, SDU 1999-2008 Associate Professor Department of Biochemistry and Molecular Biology, SDU 2008 – pres. Professor Department of Biochemistry and Molecular Biology, SDU

Research profile The research in the group is focused on understanding the cross-talk between metabolism and transcriptional regulation of gene expression with a particular focus on pancreatic β-cells, adipocytes and adipocyte differentiation. The group is particularly interested in the function, regulation and mechanism of action of transcription factors of the peroxisome proliferator activated receptors (PPARs) family. We have recently established high throughput sequencing for the use in genome-wide mapping of transcription factors and epigenetic marks and have used this to map transcriptional chromatin and transcriptional changes during differentiation and in response to nutrients. Finally, the Mandrup laboratory has a long-standing interest in lipid binding proteins and has generated conventional as well as tissue specific targeted disruption of the acyl-CoA binding protein (ACBP) in mice.